Image by Peter H. Seeberger

The earliest documented case of β-thalassemia in Sardinia suggests malaria was widespread on the island long before the Middle Ages, according to researchers.

The team noted that Sardinia has one of the highest incidence rates of β-thalassemia in Europe due to its long history of endemic malaria.

However, it has been assumed that malaria was only endemic on the island since the Middle Ages (500-1500 CE).

New research, published in the American Journal of Physical Anthropology, suggests malaria was probably already endemic on Sardinia during the Roman period.

Since ancient DNA of malaria is difficult to extract, the researchers studied thalassemia and other genetic adaptations in its place.

The team studied a thalassemia allele called cod39 β-thalassemia, which is dominant on Sardinia. They were able to confirm the presence of the cod39 allele in the 2000-year-old (approximately 300 BCE to 100 CE) remains of a Roman man.

“This is the very first documented case of the genetic adaptation to malaria on Sardinia,” said study author Claudia Vigano, of the Institute for Evolutionary Medicine of the University of Zurich in Switzerland.

“We also discovered that the person was genetically a Sardinian in all probability and not an immigrant from another area.”

“Our study shows the importance of a multidisciplinary approach to history,” said Abigail Bouwman, also of the Institute for Evolutionary Medicine of the University of Zurich.

“We are researching the evolution of today’s diseases, such as malaria, to explain why the human body becomes sick at all and how adaptations occur.”

Image by Peter H. Seeberger

The earliest documented case of β-thalassemia in Sardinia suggests malaria was widespread on the island long before the Middle Ages, according to researchers.

The team noted that Sardinia has one of the highest incidence rates of β-thalassemia in Europe due to its long history of endemic malaria.

However, it has been assumed that malaria was only endemic on the island since the Middle Ages (500-1500 CE).

New research, published in the American Journal of Physical Anthropology, suggests malaria was probably already endemic on Sardinia during the Roman period.

Since ancient DNA of malaria is difficult to extract, the researchers studied thalassemia and other genetic adaptations in its place.

The team studied a thalassemia allele called cod39 β-thalassemia, which is dominant on Sardinia. They were able to confirm the presence of the cod39 allele in the 2000-year-old (approximately 300 BCE to 100 CE) remains of a Roman man.

“This is the very first documented case of the genetic adaptation to malaria on Sardinia,” said study author Claudia Vigano, of the Institute for Evolutionary Medicine of the University of Zurich in Switzerland.

“We also discovered that the person was genetically a Sardinian in all probability and not an immigrant from another area.”

“Our study shows the importance of a multidisciplinary approach to history,” said Abigail Bouwman, also of the Institute for Evolutionary Medicine of the University of Zurich.

“We are researching the evolution of today’s diseases, such as malaria, to explain why the human body becomes sick at all and how adaptations occur.”

Image by Peter H. Seeberger

The earliest documented case of β-thalassemia in Sardinia suggests malaria was widespread on the island long before the Middle Ages, according to researchers.

The team noted that Sardinia has one of the highest incidence rates of β-thalassemia in Europe due to its long history of endemic malaria.

However, it has been assumed that malaria was only endemic on the island since the Middle Ages (500-1500 CE).

New research, published in the American Journal of Physical Anthropology, suggests malaria was probably already endemic on Sardinia during the Roman period.

Since ancient DNA of malaria is difficult to extract, the researchers studied thalassemia and other genetic adaptations in its place.

The team studied a thalassemia allele called cod39 β-thalassemia, which is dominant on Sardinia. They were able to confirm the presence of the cod39 allele in the 2000-year-old (approximately 300 BCE to 100 CE) remains of a Roman man.

“This is the very first documented case of the genetic adaptation to malaria on Sardinia,” said study author Claudia Vigano, of the Institute for Evolutionary Medicine of the University of Zurich in Switzerland.

“We also discovered that the person was genetically a Sardinian in all probability and not an immigrant from another area.”

“Our study shows the importance of a multidisciplinary approach to history,” said Abigail Bouwman, also of the Institute for Evolutionary Medicine of the University of Zurich.

“We are researching the evolution of today’s diseases, such as malaria, to explain why the human body becomes sick at all and how adaptations occur.”

Photo by Rhoda Baer

The American Society of Clinical Oncology (ASCO) has updated its clinical practice guidelines on the use of antiemetics in cancer patients.

The update, published in the Journal of Clinical Oncology, provides new evidence-based information on the appropriate use of olanzapine, NK1 receptor antagonists, and dexamethasone.

“The adverse impact of inadequately controlled nausea and vomiting on patients’ quality of life is well documented,” said Paul J. Hesketh, MD, co-chair of the ASCO expert panel that updated the guidelines.

“By following the ASCO antiemetics guideline, clinicians have the opportunity to improve patients’ quality of life by minimizing treatment-induced emesis.”

To update ASCO’s guidelines on antiemetics, the expert panel conducted a systematic review of the medical literature published between November 2009 and June 2016. The panel included members with expertise in medical oncology, radiation oncology, nursing, pharmacy, and health services research, as well as a patient representative.

“Tremendous progress has been realized over the last 25 years in the prevention of chemotherapy-induced nausea and vomiting with the introduction of new classes of antiemetic agents,” said Mark G. Kris, MD, co-chair of the expert panel that updated the guidelines.

“The full benefit of these treatment advances will only be realized, however, if evidence-based guidelines are fully implemented.”

Key recommendations in the updated guidelines include:

For adults receiving chemotherapy with a high risk for nausea and vomiting (eg, cisplatin or the combination of cyclophosphamide and an anthracycline), olanzapine should be added to standard antiemetic regimens (the combination of a 5-HT3 receptor antagonist, an NK1 receptor antagonist, and dexamethasone). Olanzapine also helps individuals who experience symptoms despite receiving medicines to prevent vomiting before chemotherapy is given.

For adults receiving carboplatin-based chemotherapy or high-dose chemotherapy and children receiving chemotherapy with a high risk for nausea and vomiting, an NK1 receptor antagonist should be added to the standard antiemetic regimen (the combination of 5-HT3 receptor antagonist and dexamethasone).

Dexamethasone treatment can be limited to the day of chemotherapy administration in patients receiving an anthracycline and cyclophosphamide.

Dronabinol and nabilone, cannabinoids approved by the US Food and Drug Administration, can be used to treat nausea and vomiting that is resistant to standard antiemetic therapies. Evidence remains insufficient to recommend medical marijuana for either prevention or treatment of nausea and vomiting in patients with cancer receiving chemotherapy or radiation therapy.

Photo by Rhoda Baer

The American Society of Clinical Oncology (ASCO) has updated its clinical practice guidelines on the use of antiemetics in cancer patients.

The update, published in the Journal of Clinical Oncology, provides new evidence-based information on the appropriate use of olanzapine, NK1 receptor antagonists, and dexamethasone.

“The adverse impact of inadequately controlled nausea and vomiting on patients’ quality of life is well documented,” said Paul J. Hesketh, MD, co-chair of the ASCO expert panel that updated the guidelines.

“By following the ASCO antiemetics guideline, clinicians have the opportunity to improve patients’ quality of life by minimizing treatment-induced emesis.”

To update ASCO’s guidelines on antiemetics, the expert panel conducted a systematic review of the medical literature published between November 2009 and June 2016. The panel included members with expertise in medical oncology, radiation oncology, nursing, pharmacy, and health services research, as well as a patient representative.

“Tremendous progress has been realized over the last 25 years in the prevention of chemotherapy-induced nausea and vomiting with the introduction of new classes of antiemetic agents,” said Mark G. Kris, MD, co-chair of the expert panel that updated the guidelines.

“The full benefit of these treatment advances will only be realized, however, if evidence-based guidelines are fully implemented.”

Key recommendations in the updated guidelines include:

For adults receiving chemotherapy with a high risk for nausea and vomiting (eg, cisplatin or the combination of cyclophosphamide and an anthracycline), olanzapine should be added to standard antiemetic regimens (the combination of a 5-HT3 receptor antagonist, an NK1 receptor antagonist, and dexamethasone). Olanzapine also helps individuals who experience symptoms despite receiving medicines to prevent vomiting before chemotherapy is given.

For adults receiving carboplatin-based chemotherapy or high-dose chemotherapy and children receiving chemotherapy with a high risk for nausea and vomiting, an NK1 receptor antagonist should be added to the standard antiemetic regimen (the combination of 5-HT3 receptor antagonist and dexamethasone).

Dexamethasone treatment can be limited to the day of chemotherapy administration in patients receiving an anthracycline and cyclophosphamide.

Dronabinol and nabilone, cannabinoids approved by the US Food and Drug Administration, can be used to treat nausea and vomiting that is resistant to standard antiemetic therapies. Evidence remains insufficient to recommend medical marijuana for either prevention or treatment of nausea and vomiting in patients with cancer receiving chemotherapy or radiation therapy.

Photo by Rhoda Baer

The American Society of Clinical Oncology (ASCO) has updated its clinical practice guidelines on the use of antiemetics in cancer patients.

The update, published in the Journal of Clinical Oncology, provides new evidence-based information on the appropriate use of olanzapine, NK1 receptor antagonists, and dexamethasone.

“The adverse impact of inadequately controlled nausea and vomiting on patients’ quality of life is well documented,” said Paul J. Hesketh, MD, co-chair of the ASCO expert panel that updated the guidelines.

“By following the ASCO antiemetics guideline, clinicians have the opportunity to improve patients’ quality of life by minimizing treatment-induced emesis.”

To update ASCO’s guidelines on antiemetics, the expert panel conducted a systematic review of the medical literature published between November 2009 and June 2016. The panel included members with expertise in medical oncology, radiation oncology, nursing, pharmacy, and health services research, as well as a patient representative.

“Tremendous progress has been realized over the last 25 years in the prevention of chemotherapy-induced nausea and vomiting with the introduction of new classes of antiemetic agents,” said Mark G. Kris, MD, co-chair of the expert panel that updated the guidelines.

“The full benefit of these treatment advances will only be realized, however, if evidence-based guidelines are fully implemented.”

Key recommendations in the updated guidelines include:

For adults receiving chemotherapy with a high risk for nausea and vomiting (eg, cisplatin or the combination of cyclophosphamide and an anthracycline), olanzapine should be added to standard antiemetic regimens (the combination of a 5-HT3 receptor antagonist, an NK1 receptor antagonist, and dexamethasone). Olanzapine also helps individuals who experience symptoms despite receiving medicines to prevent vomiting before chemotherapy is given.

For adults receiving carboplatin-based chemotherapy or high-dose chemotherapy and children receiving chemotherapy with a high risk for nausea and vomiting, an NK1 receptor antagonist should be added to the standard antiemetic regimen (the combination of 5-HT3 receptor antagonist and dexamethasone).

Dexamethasone treatment can be limited to the day of chemotherapy administration in patients receiving an anthracycline and cyclophosphamide.

Dronabinol and nabilone, cannabinoids approved by the US Food and Drug Administration, can be used to treat nausea and vomiting that is resistant to standard antiemetic therapies. Evidence remains insufficient to recommend medical marijuana for either prevention or treatment of nausea and vomiting in patients with cancer receiving chemotherapy or radiation therapy.

Thirty-six percent of children enrolled in Medicaid have noncomplex chronic diseases (NC-CDs), such as asthma, diabetes, or depression, accounting for a third of Medicaid pediatric expenditures, according to a retrospective, cross-sectional analysis.

Generalizing to the 35 million children on Medicaid nationally, the NC-CD population accounts for $35 billion in annual Medicaid spending (Pediatrics. 2017. doi: 10.1542/peds.2017-0492).

sndr/istockphoto

[email protected]

Thirty-six percent of children enrolled in Medicaid have noncomplex chronic diseases (NC-CDs), such as asthma, diabetes, or depression, accounting for a third of Medicaid pediatric expenditures, according to a retrospective, cross-sectional analysis.

Generalizing to the 35 million children on Medicaid nationally, the NC-CD population accounts for $35 billion in annual Medicaid spending (Pediatrics. 2017. doi: 10.1542/peds.2017-0492).

sndr/istockphoto

[email protected]

Thirty-six percent of children enrolled in Medicaid have noncomplex chronic diseases (NC-CDs), such as asthma, diabetes, or depression, accounting for a third of Medicaid pediatric expenditures, according to a retrospective, cross-sectional analysis.

Generalizing to the 35 million children on Medicaid nationally, the NC-CD population accounts for $35 billion in annual Medicaid spending (Pediatrics. 2017. doi: 10.1542/peds.2017-0492).

sndr/istockphoto

[email protected]

CE/CME No: CR-1708

PROGRAM OVERVIEW
Earn credit by reading this article and successfully completing the posttest and evaluation. Successful completion is defined as a cumulative score of at least 70% correct.

EDUCATIONAL OBJECTIVES
• Discuss the importance of diagnosing the type of anemia in order to provide appropriate treatment.
• Describe how the complete blood count and its indices are used to initially determine if an anemia is microcytic, normocytic, or macrocytic.
• List the more common causes of microcytic, normocytic, and macrocytic anemia.
• Discuss addictional laboratory tests that may be used to further assess the cause of anemia.

FACULTY
Jean O’Neil is an Assistant Professor and Coordinator of the Adult Gerontology Acute Care Nurse Practitioner Program in the Patricia A. Chin School of Nursing at California State University, Los Angeles.

ACCREDITATION STATEMENT

This program has been reviewed and is approved for a maximum of 1.0 hour of American Academy of Physician Assistants (AAPA) Category 1 CME credit by the Physician Assistant Review Panel. [NPs: Both ANCC and the AANP Certification Program recognize AAPA as an approved provider of Category 1 credit.] Approval is valid through July 31, 2018.

Article begins on next page >>

Anemia affects more than 3 million people in the United States, making it a common problem in primary care practices. Once anemia is detected, clinicians must define the type and identify its underlying cause prior to initiating treatment. In most cases, the cause can be determined using information from the patient history, physical exam, and complete blood count.

Anemia is commonly identified during routine physical exams and laboratory testing.^1-3 However, treating anemia can present a challenge for the primary care provider if the immediate cause is not apparent. Iron deficiency is a leading cause of anemia, but simply prescribing an iron supplement without determining the type or the cause of the anemia is not appropriate. Anemia that is misdiagnosed or goes untreated can be associated with a worse prognosis, as well as increased health care costs.⁴

Primary care providers often manage patients with common types of anemia and refer patients with severe or complex anemia to specialists for further testing and treatment. The most commonly used and cost-effective diagnostic tool for anemia is the complete blood count (CBC).^2-6 The CBC provides details that can help the provider determine the type of anemia present, which in turn guides proper diagnostic testing and treatment.

EPIDEMIOLOGY

Anemia involves a reduction in the number of circulating red blood cells, the blood hemoglobin content, or the hematocrit, which leads to impaired delivery of oxygen to the body. Anemia affects more than 2 billion people worldwide, with iron deficiency the most common cause.⁷ Other leading nutritional causes of anemia include vitamin B₁₂ and folate deficiency.^4,7 Approximately 3 to 4 million Americans have anemia in some form, and it affects about 6.6% of men and 12.4% of women.^5,8 The prevalence of anemia increases with age. Approximately 11% of men and 10% of women ages 65 or older have anemia, and in men ages 85 or older, prevalence of 20% to 44% has been reported.^1,4 Anemia is present in about 3.5% of patients with chronic disease, but only 15% of them receive treatment.⁴

PATHOPHYSIOLOGY

Blood is composed of water-based plasma (54%), white blood cells and platelets (1%), and red blood cells (45%).⁵ Hemoglobin, the primary protein of the red blood cell, binds oxygen from the lungs and transports it to the rest of the body. Oxygen is then exchanged for carbon dioxide, which is carried back to the lungs to be exhaled.

Hemoglobin is made up of four globin chains, each containing an iron ion held in a porphyrin ring known as a heme group.⁵ When the body detects low tissue oxygen, the endothelial cells in the kidneys secrete the hormone erythropoietin (EPO), which stimulates the bone marrow to increase red cell production.⁵ This feedback loop can be interrupted by renal failure or chronic disease.⁴ In addition, bone marrow cannot produce enough red blood cells if there are insufficient levels of iron, amino acids, protein, carbohydrates, lipids, folate, and vitamin B₁₂.⁵ Toxins (eg, lead), some types of cancer (eg, lymphoma), or even common infections (eg, pneumonia) can suppress the bone marrow, causing anemia. The more severe the anemia, the more likely oxygen transport will be compromised and organ failure will ensue.

Mutations affecting the genes that encode the globin chains within hemoglobin can cause one of the more than 600 known hemoglobinopathies (genetic defects of hemoglobin structure), such as sickle cell disease and thalassemias.^5,9 While it is important to identify and treat patients with hemoglobinopathies, most anemias have other causes, such as iron deficiency, chronic disease, bone marrow defects, B₁₂ deficiency, renal failure, medications, alcoholism, pregnancy, nutritional intake problems, gastrointestinal malabsorption, and active or recent history of blood loss.^5,10

CLINICAL PRESENTATION

There are several signs and symptoms that should lead the primary care provider to suspect anemia (see Table 1).^5,6 The severity of these symptoms can vary from mild to very serious. Severe anemia can lead to organ failure and death. However, most patients with anemia are asymptomatic, and anemia is typically detected incidentally during laboratory testing.^1,2

Once anemia is confirmed, the evaluation focuses on diagnosing its underlying cause. It should include a thorough patient history and review of systems to ascertain whether the patient has symptoms such as increased fatigue, palpitations, gastrointestinal distress, weakness, or dizziness.

If the provider has access to past CBC results, a comparison of the current and previous results will help determine whether the anemia is acute or chronic. Anemia caused by acute conditions, such as a suspicion of blood loss or bone marrow suppression, must be attended to immediately. A patient with chronic anemia should be carefully monitored and may need follow-up for ongoing treatment. While a provider has more time to work up a patient with chronic anemia, the causes may not be as straight­forward.

DIAGNOSIS AND CLASSIFICATION

Anemia in adults is defined as hemoglobin less than 13 g/dL in males and 12 g/dL in females.⁶ The hemoglobin is part of the complete blood cell report, which also includes the white blood cell count (WBC), red blood cell count (RBC), hematocrit, platelet count, and indices.

When investigating the underlying cause of anemia, the most useful parts of the CBC are the hemoglobin and the mean corpuscular volume (MCV; see Table 2).^6,10 The MCV is the average volume of red cells in a specimen. This parameter is used to classify the anemia as microcytic (MCV < 80 fL), normocytic (MCV 80-100 fL), or macrocytic (MCV > 100 fL), which helps to narrow the differential diagnosis and guide any further testing (see Figure).^5,6,10

It is important to note that the normal ranges of the CBC parameters differ based on race, with persons of African ancestry having lower normal hemoglobin levels than persons of Caucasian ancestry.¹⁰ In addition, laboratories may have slightly different normal values for the CBC based on the equipment they utilize. Therefore, providers must follow their laboratory’s parameters, as well as adjust for the patient’s gender, age, and ethnicity.¹⁰

Microcytic Anemia

Iron deficiency

In microcytic anemia, the RBCs are smaller than average (MCV < 80 fL), as well as hypochromic due to lack of hemoglobin.⁹ Iron deficiency is the most common cause of microcytic anemia worldwide.^11,12 Therefore, when a patient has microcytic anemia, a serum ferritin needs to be ordered. Further testing of total iron-binding capacity (TIBC), transferrin saturation, serum iron, and serum receptor levels may be helpful if the ferritin level is between 46-99 ng/mL and anemia due to iron deficiency is not confirmed (see Table 2).¹²

In iron deficiency anemia, serum ferritin and serum iron levels are low due to lack of iron, but serum TIBC is high.⁶ The elevated TIBC reflects increased synthesis of transferrin by the liver as it attempts to compensate for the patient’s low serum iron level.⁹ Since iron levels are controlled by absorption rather than excretion, iron is essentially only depleted from the body through blood loss.¹² Therefore, an adult patient who is iron deficient has lost more iron through blood loss than was replaced through nutritional intake and gastrointestinal absorption. In children, increased growth-related iron requirements combined with poor nutritional intake of iron-rich foods is an additional mechanism for iron deficiency.¹¹

Iron deficiency in all men and nonmenstruating women should always be worked up for possible blood loss due to abnormal (eg, gastrointestinal) bleeding or nonphysiologic (eg, poor dietary intake of iron) causes.^11,12 Additional clinical findings associated with chronic iron deficiency include glossitis, angular stomatitis, and koilonych­ias (spoon-shaped nails).¹²

If the nutritional problem is corrected or the source of bleeding is controlled, treatment with oral or intravenous iron supplements should result in improved serum hemoglobin and reticulocyte counts.¹³ In the primary care setting, ferrous sulfate 325 mg, which provides 65 mg of elemental iron per tablet, orally three times daily is recommended for adults.¹³ This gives the patient the recommended dose of approximately 200 mg of elemental iron. Repeat hemoglobin and iron studies should be conducted again in three to six months.^12,13

If the patient’s iron deficiency anemia does not improve after oral iron therapy, there may be a source of blood loss the provider missed or a problem with malabsorption of iron, which can be seen in those who have undergone gastric bypass surgery or who have inflammatory bowel disease.¹³ Such patients should be referred to a specialist, such as a gastroenterologist, for further evaluation.

Thalassemia

Microcytic anemia with normal or elevated serum iron and normal-to-increased serum ferritin can be seen in patients with a type of thalassemia (see Figure).² Thalassemias are inherited blood disorders that reduce hemoglobin production, leading to microcytosis; they are more common in those of Mediterranean, African, and Southeast Asian descent.² Red cells in patients with a form of thalassemia are usually very small (microcytic) and have normal or elevated red cell distribution width (RDW).¹⁰

Moderate and severe forms of thalassemia can cause anemia. However, thalassemia syndromes that can cause severe (transfusion-dependent) anemia are usually diagnosed in childhood.⁹ Patients with one of the minor forms of thalassemia typically need minimal to no treatment.⁵ A patient with significant anemia suspicious for thalassemia should undergo hemoglobin electrophoresis testing to confirm the diagnosis and to determine the type of thalassemia.² Typically, hemoglobin electrophoresis is normal in α thalassemia and is abnormal in ß thalassemia, as well as other forms of thalassemia. Referral to a hematologist for interpretation of these results and for further evaluation is appropriate.¹⁰

Chronic disease

If the patient has microcytic anemia and is not iron deficient or does not have thalassemia, then anemia related to a chronic disease should be considered.⁵ In such cases, the provider should order a reticulocyte count, which reveals how the bone marrow is responding to the anemia.⁵ Reticulocytes are immature red cells that have just been released from the bone marrow into the blood stream. The bone marrow increases the release of these cells in response to anemia.⁶

Any condition that stimulates reticulocyte production or prevents the bone marrow from producing reticulocytes will result in abnormal values (see Table 3). A normal reticulocyte count, expressed as the reticulocyte production index, is between 0.5% and 1.5%.⁵ The reticulocyte count is low in iron deficiency anemia and diseases that lead to decreased bone marrow production.^5,6 Bone marrow suppression can occur in the context of chronic disease, infection, or inflammation. Malignancies are a less common cause for chronic disease microcytic anemia.⁶

If the cause of the decreased reticulocyte count is iron deficiency anemia, then treatment with iron supplementation should result in an increased reticulocyte count within one week.¹³ The primary care provider works in conjunction with the specialist to monitor the patient’s anemia when it is due to chronic disease or malignancy.

MACROCYTIC ANEMIA

In macrocytic anemia, the RBCs are larger than normal (MCV > 100 fL). This form of anemia is usually caused by vitamin B₁₂ and folate deficiency, but it can also result from alcoholism, certain medications (eg, chemotherapy, antivirals), bone marrow disorders (eg, leukemia), and liver disease (eg, cirrhosis; see Figure).^5,14 Common medications that can cause macrocytosis include the antiseizure drug phenytoin, the antibiotics trimethoprim/sulfamethoxazole and nitrofurantoin, the disease-modifying antirheumatic drug sulfasalazine, and immunosuppressants such as azathioprine.^14,15 Antiviral agents, such as reverse transcriptase inhibitors (eg, zidovudine) used to treat HIV infection, can also cause macrocytosis with or without anemia.^6,14

Macrocytic anemias caused by low serum levels of B₁₂ and folate usually reflect problems with gastrointestinal malabsorption. For example, gastric bypass or Crohn disease can lead to malabsorption of vitamin B₁₂ and increase a patient’s risk for macrocytic anemia.¹³

Vitamin B₁₂ deficiency occurs in patients with pernicious anemia because they are missing intrinsic factor, which is necessary to facilitate B₁₂ absorption in the ileum.¹⁰ Low vitamin B₁₂ and folate levels also can result from inadequate dietary intake, although this is rare in the United States due to mandatory fortification of certain foods. A diet low in fresh vegetables is the leading cause of folate deficiency. While folate deficiency related to poor nutritional intake can be seen in all age groups, vitamin B₁₂ deficiency more frequently affects the elderly or persons following a strict vegan diet.¹⁴

In addition to the fatigue and pallor associated with macrocytic anemia, patients with vitamin B₁₂ deficiency may also have a smooth tongue, peripheral neuropathy, and edema.^5,14 Severe vitamin B₁₂ deficiency can lead to subacute combined degeneration of the spinal cord, with demyelination of the dorsal and lateral columns most often occurring in the cervical and thoracic regions.^16,17 This spinal cord degeneration can cause paresthesia, muscle spasticity, and ataxia.¹⁶

When there is a macrocytic anemia, but the B₁₂ or folate level is only borderline low, additional tests should be performed to help distinguish between B₁₂ and folate deficiency. Both B₁₂ and folate deficiencies can cause elevated homocysteine levels.¹³ Clinically significant B₁₂ deficiency causes elevation of methylmalonic acid (MMA), whereas folate deficiency does not.^13,14 Elevation of MMA can be very sensitive for B₁₂ deficiency but lacks specificity in certain situations, such as pregnancy, renal insufficiency, and advanced age.^13,14

Treatment of vitamin B₁₂ and folate deficiencies with supplementation prevents progression of the disease, and has the potential to relieve most of the symptoms. Oral, sublingual, or parenteral vitamin B₁₂ or oral folate supplements can be started in the primary care setting once the provider has identified whether the patient is B₁₂ deficient, folate deficient, or both.

The vitamin B₁₂ dose used for deficiency-induced macrocytic anemia depends on the cause—for example, a temporary condition such as pregnancy versus a lifelong disorder such as pernicious anemia.¹³ The usual oral dosing regimen is 2 mg/d; if intramuscular injections are used, 50 to 100 mcg are given daily for a week, followed by weekly injections for a month, and then monthly injections of 1 mg for life, if necessary.¹³ Bone marrow response to supplemental B₁₂ is very rapid, with increased reticulocyte counts seen within four or five days.¹³

The usual dose for oral folic acid is 1 mg/d as needed.¹³ Folic acid can be given for folate deficiency only if the vitamin B₁₂ level is normal. Giving folate to a patient with untreated vitamin B₁₂ deficiency can potentially worsen subacute combined degeneration of the spinal cord.^13,16

NORMOCYTIC ANEMIA

In normocytic anemia, the hemoglobin is low but the MCV is normal (see Figure).¹ The history and physical exam should provide clues about whether the underlying cause of the anemia requires emergent (eg, active bleeding) or nonemergent (eg, anemia of chronic disease) management. Some of the causes of normocytic anemia are active bleeding, pregnancy, malnutrition, renal failure, chronic disease, hemolytic disorders, hypersplenism, congenital disorders, endocrine disorders, infection, and primary bone marrow disorders.^1,5 Expanded plasma volume, as seen in pregnancy and overhydration, can also cause normocytic anemia.⁵ If gastrointestinal bleeding is suspected or the patient reports dark, tarry stools consistent with melena, fecal occult blood testing should be done. A positive result strongly supports gastrointestinal bleeding as the cause of the anemia.¹⁸

The reticulocyte count can also be helpful in identifying the cause of this type of anemia. A normocytic anemia with a normal reticulocyte and normal RDW count is usually related to chronic disease.^1,10 For example, chronic kidney disease (CKD) is associated with decreased EPO production due to impaired renal function, which leads to reduced erythropoiesis. Decreased EPO prevents the bone marrow from making red blood cells, resulting in anemia. However, a normocytic anemia with an elevated reticulocyte count points to bleeding or hemolysis, as the reticulosis shows that the bone marrow is increasing red cell production to make up for the lost red cells.⁵

Additional diagnostic laboratory testing for patients with normocytic anemia may involve, for example, creatinine and blood urea nitrogen for patients with CKD, prothrombin time with an INR and liver function tests for patients with liver disease, and urine human chorionic gonadotropin if pregnancy is suspected.

For patients with an infection that is causing severe hemolysis (eg, sepsis due to a ß-hemolytic streptococcal infection), blood cultures should be drawn.⁵ If red blood cell destruction due to an artificial cardiac valve or an autoimmune disorder is suspected as the cause of the anemia, a hematology consult is needed.¹ Anemia caused by disseminated intravascular coagulation or thrombotic thrombocytopenic purpura resulting in hemolysis are usually emergent conditions that require immediate intervention, including hospitalization and management by a hematologist.¹

PATIENT EDUCATION

Patients and any accompanying family members should be educated about the signs and symptoms of anemia, the diagnostic testing and treatment regimens specific to their anemia, and medication compliance issues.

For instance, patients who abuse alcohol often have both vitamin B₁₂ and folate deficiencies. If the macrocytosis is caused by alcohol intake, then the provider should educate the patient on the importance of alcohol abstention, as well as refer the patient for rehabilitation and psychologic counseling, as needed. These patients can sometimes recover from macrocytic anemia simply by stopping alcohol intake and improving their nutrition.¹⁹ Patients with microcytosis due to iron deficiency anemia should be advised about the importance of good nutrition and compliance with iron supplementation.

Repeat CBCs and a follow-up patient history and physical exam will help the provider assess whether the anemia is resolving. Individualized plans that target the specific type of anemia identified, as well as its underlying cause, are key to successful treatment.

CONCLUSION

When managing a patient with anemia, providers must define the type of anemia present and identify its underlying cause before starting treatment. Clues from the patient’s history, physical exam, and CBC can help isolate the cause of anemia. The MCV is the most helpful of the red blood cell indices because it allows the provider to classify the anemia as microcytic, macrocytic, or normocytic.

In cases in which the anemia is acute or ­severe—or in which the patient remains anemic even after being treated by the primary care provider—referral to a specialist is ­appropriate.

CE/CME No: CR-1708

PROGRAM OVERVIEW
Earn credit by reading this article and successfully completing the posttest and evaluation. Successful completion is defined as a cumulative score of at least 70% correct.

EDUCATIONAL OBJECTIVES
• Discuss the importance of diagnosing the type of anemia in order to provide appropriate treatment.
• Describe how the complete blood count and its indices are used to initially determine if an anemia is microcytic, normocytic, or macrocytic.
• List the more common causes of microcytic, normocytic, and macrocytic anemia.
• Discuss addictional laboratory tests that may be used to further assess the cause of anemia.

FACULTY
Jean O’Neil is an Assistant Professor and Coordinator of the Adult Gerontology Acute Care Nurse Practitioner Program in the Patricia A. Chin School of Nursing at California State University, Los Angeles.

ACCREDITATION STATEMENT

This program has been reviewed and is approved for a maximum of 1.0 hour of American Academy of Physician Assistants (AAPA) Category 1 CME credit by the Physician Assistant Review Panel. [NPs: Both ANCC and the AANP Certification Program recognize AAPA as an approved provider of Category 1 credit.] Approval is valid through July 31, 2018.

Article begins on next page >>

Anemia affects more than 3 million people in the United States, making it a common problem in primary care practices. Once anemia is detected, clinicians must define the type and identify its underlying cause prior to initiating treatment. In most cases, the cause can be determined using information from the patient history, physical exam, and complete blood count.

Anemia is commonly identified during routine physical exams and laboratory testing.^1-3 However, treating anemia can present a challenge for the primary care provider if the immediate cause is not apparent. Iron deficiency is a leading cause of anemia, but simply prescribing an iron supplement without determining the type or the cause of the anemia is not appropriate. Anemia that is misdiagnosed or goes untreated can be associated with a worse prognosis, as well as increased health care costs.⁴

Primary care providers often manage patients with common types of anemia and refer patients with severe or complex anemia to specialists for further testing and treatment. The most commonly used and cost-effective diagnostic tool for anemia is the complete blood count (CBC).^2-6 The CBC provides details that can help the provider determine the type of anemia present, which in turn guides proper diagnostic testing and treatment.

EPIDEMIOLOGY

Anemia involves a reduction in the number of circulating red blood cells, the blood hemoglobin content, or the hematocrit, which leads to impaired delivery of oxygen to the body. Anemia affects more than 2 billion people worldwide, with iron deficiency the most common cause.⁷ Other leading nutritional causes of anemia include vitamin B₁₂ and folate deficiency.^4,7 Approximately 3 to 4 million Americans have anemia in some form, and it affects about 6.6% of men and 12.4% of women.^5,8 The prevalence of anemia increases with age. Approximately 11% of men and 10% of women ages 65 or older have anemia, and in men ages 85 or older, prevalence of 20% to 44% has been reported.^1,4 Anemia is present in about 3.5% of patients with chronic disease, but only 15% of them receive treatment.⁴

PATHOPHYSIOLOGY

Blood is composed of water-based plasma (54%), white blood cells and platelets (1%), and red blood cells (45%).⁵ Hemoglobin, the primary protein of the red blood cell, binds oxygen from the lungs and transports it to the rest of the body. Oxygen is then exchanged for carbon dioxide, which is carried back to the lungs to be exhaled.

Hemoglobin is made up of four globin chains, each containing an iron ion held in a porphyrin ring known as a heme group.⁵ When the body detects low tissue oxygen, the endothelial cells in the kidneys secrete the hormone erythropoietin (EPO), which stimulates the bone marrow to increase red cell production.⁵ This feedback loop can be interrupted by renal failure or chronic disease.⁴ In addition, bone marrow cannot produce enough red blood cells if there are insufficient levels of iron, amino acids, protein, carbohydrates, lipids, folate, and vitamin B₁₂.⁵ Toxins (eg, lead), some types of cancer (eg, lymphoma), or even common infections (eg, pneumonia) can suppress the bone marrow, causing anemia. The more severe the anemia, the more likely oxygen transport will be compromised and organ failure will ensue.

Mutations affecting the genes that encode the globin chains within hemoglobin can cause one of the more than 600 known hemoglobinopathies (genetic defects of hemoglobin structure), such as sickle cell disease and thalassemias.^5,9 While it is important to identify and treat patients with hemoglobinopathies, most anemias have other causes, such as iron deficiency, chronic disease, bone marrow defects, B₁₂ deficiency, renal failure, medications, alcoholism, pregnancy, nutritional intake problems, gastrointestinal malabsorption, and active or recent history of blood loss.^5,10

CLINICAL PRESENTATION

There are several signs and symptoms that should lead the primary care provider to suspect anemia (see Table 1).^5,6 The severity of these symptoms can vary from mild to very serious. Severe anemia can lead to organ failure and death. However, most patients with anemia are asymptomatic, and anemia is typically detected incidentally during laboratory testing.^1,2

Once anemia is confirmed, the evaluation focuses on diagnosing its underlying cause. It should include a thorough patient history and review of systems to ascertain whether the patient has symptoms such as increased fatigue, palpitations, gastrointestinal distress, weakness, or dizziness.

If the provider has access to past CBC results, a comparison of the current and previous results will help determine whether the anemia is acute or chronic. Anemia caused by acute conditions, such as a suspicion of blood loss or bone marrow suppression, must be attended to immediately. A patient with chronic anemia should be carefully monitored and may need follow-up for ongoing treatment. While a provider has more time to work up a patient with chronic anemia, the causes may not be as straight­forward.

DIAGNOSIS AND CLASSIFICATION

Anemia in adults is defined as hemoglobin less than 13 g/dL in males and 12 g/dL in females.⁶ The hemoglobin is part of the complete blood cell report, which also includes the white blood cell count (WBC), red blood cell count (RBC), hematocrit, platelet count, and indices.

When investigating the underlying cause of anemia, the most useful parts of the CBC are the hemoglobin and the mean corpuscular volume (MCV; see Table 2).^6,10 The MCV is the average volume of red cells in a specimen. This parameter is used to classify the anemia as microcytic (MCV < 80 fL), normocytic (MCV 80-100 fL), or macrocytic (MCV > 100 fL), which helps to narrow the differential diagnosis and guide any further testing (see Figure).^5,6,10

It is important to note that the normal ranges of the CBC parameters differ based on race, with persons of African ancestry having lower normal hemoglobin levels than persons of Caucasian ancestry.¹⁰ In addition, laboratories may have slightly different normal values for the CBC based on the equipment they utilize. Therefore, providers must follow their laboratory’s parameters, as well as adjust for the patient’s gender, age, and ethnicity.¹⁰

Microcytic Anemia

Iron deficiency

In microcytic anemia, the RBCs are smaller than average (MCV < 80 fL), as well as hypochromic due to lack of hemoglobin.⁹ Iron deficiency is the most common cause of microcytic anemia worldwide.^11,12 Therefore, when a patient has microcytic anemia, a serum ferritin needs to be ordered. Further testing of total iron-binding capacity (TIBC), transferrin saturation, serum iron, and serum receptor levels may be helpful if the ferritin level is between 46-99 ng/mL and anemia due to iron deficiency is not confirmed (see Table 2).¹²

In iron deficiency anemia, serum ferritin and serum iron levels are low due to lack of iron, but serum TIBC is high.⁶ The elevated TIBC reflects increased synthesis of transferrin by the liver as it attempts to compensate for the patient’s low serum iron level.⁹ Since iron levels are controlled by absorption rather than excretion, iron is essentially only depleted from the body through blood loss.¹² Therefore, an adult patient who is iron deficient has lost more iron through blood loss than was replaced through nutritional intake and gastrointestinal absorption. In children, increased growth-related iron requirements combined with poor nutritional intake of iron-rich foods is an additional mechanism for iron deficiency.¹¹

Iron deficiency in all men and nonmenstruating women should always be worked up for possible blood loss due to abnormal (eg, gastrointestinal) bleeding or nonphysiologic (eg, poor dietary intake of iron) causes.^11,12 Additional clinical findings associated with chronic iron deficiency include glossitis, angular stomatitis, and koilonych­ias (spoon-shaped nails).¹²

If the nutritional problem is corrected or the source of bleeding is controlled, treatment with oral or intravenous iron supplements should result in improved serum hemoglobin and reticulocyte counts.¹³ In the primary care setting, ferrous sulfate 325 mg, which provides 65 mg of elemental iron per tablet, orally three times daily is recommended for adults.¹³ This gives the patient the recommended dose of approximately 200 mg of elemental iron. Repeat hemoglobin and iron studies should be conducted again in three to six months.^12,13

If the patient’s iron deficiency anemia does not improve after oral iron therapy, there may be a source of blood loss the provider missed or a problem with malabsorption of iron, which can be seen in those who have undergone gastric bypass surgery or who have inflammatory bowel disease.¹³ Such patients should be referred to a specialist, such as a gastroenterologist, for further evaluation.

Thalassemia

Microcytic anemia with normal or elevated serum iron and normal-to-increased serum ferritin can be seen in patients with a type of thalassemia (see Figure).² Thalassemias are inherited blood disorders that reduce hemoglobin production, leading to microcytosis; they are more common in those of Mediterranean, African, and Southeast Asian descent.² Red cells in patients with a form of thalassemia are usually very small (microcytic) and have normal or elevated red cell distribution width (RDW).¹⁰

Moderate and severe forms of thalassemia can cause anemia. However, thalassemia syndromes that can cause severe (transfusion-dependent) anemia are usually diagnosed in childhood.⁹ Patients with one of the minor forms of thalassemia typically need minimal to no treatment.⁵ A patient with significant anemia suspicious for thalassemia should undergo hemoglobin electrophoresis testing to confirm the diagnosis and to determine the type of thalassemia.² Typically, hemoglobin electrophoresis is normal in α thalassemia and is abnormal in ß thalassemia, as well as other forms of thalassemia. Referral to a hematologist for interpretation of these results and for further evaluation is appropriate.¹⁰

Chronic disease

If the patient has microcytic anemia and is not iron deficient or does not have thalassemia, then anemia related to a chronic disease should be considered.⁵ In such cases, the provider should order a reticulocyte count, which reveals how the bone marrow is responding to the anemia.⁵ Reticulocytes are immature red cells that have just been released from the bone marrow into the blood stream. The bone marrow increases the release of these cells in response to anemia.⁶

Any condition that stimulates reticulocyte production or prevents the bone marrow from producing reticulocytes will result in abnormal values (see Table 3). A normal reticulocyte count, expressed as the reticulocyte production index, is between 0.5% and 1.5%.⁵ The reticulocyte count is low in iron deficiency anemia and diseases that lead to decreased bone marrow production.^5,6 Bone marrow suppression can occur in the context of chronic disease, infection, or inflammation. Malignancies are a less common cause for chronic disease microcytic anemia.⁶

If the cause of the decreased reticulocyte count is iron deficiency anemia, then treatment with iron supplementation should result in an increased reticulocyte count within one week.¹³ The primary care provider works in conjunction with the specialist to monitor the patient’s anemia when it is due to chronic disease or malignancy.

MACROCYTIC ANEMIA

In macrocytic anemia, the RBCs are larger than normal (MCV > 100 fL). This form of anemia is usually caused by vitamin B₁₂ and folate deficiency, but it can also result from alcoholism, certain medications (eg, chemotherapy, antivirals), bone marrow disorders (eg, leukemia), and liver disease (eg, cirrhosis; see Figure).^5,14 Common medications that can cause macrocytosis include the antiseizure drug phenytoin, the antibiotics trimethoprim/sulfamethoxazole and nitrofurantoin, the disease-modifying antirheumatic drug sulfasalazine, and immunosuppressants such as azathioprine.^14,15 Antiviral agents, such as reverse transcriptase inhibitors (eg, zidovudine) used to treat HIV infection, can also cause macrocytosis with or without anemia.^6,14

Macrocytic anemias caused by low serum levels of B₁₂ and folate usually reflect problems with gastrointestinal malabsorption. For example, gastric bypass or Crohn disease can lead to malabsorption of vitamin B₁₂ and increase a patient’s risk for macrocytic anemia.¹³

Vitamin B₁₂ deficiency occurs in patients with pernicious anemia because they are missing intrinsic factor, which is necessary to facilitate B₁₂ absorption in the ileum.¹⁰ Low vitamin B₁₂ and folate levels also can result from inadequate dietary intake, although this is rare in the United States due to mandatory fortification of certain foods. A diet low in fresh vegetables is the leading cause of folate deficiency. While folate deficiency related to poor nutritional intake can be seen in all age groups, vitamin B₁₂ deficiency more frequently affects the elderly or persons following a strict vegan diet.¹⁴

In addition to the fatigue and pallor associated with macrocytic anemia, patients with vitamin B₁₂ deficiency may also have a smooth tongue, peripheral neuropathy, and edema.^5,14 Severe vitamin B₁₂ deficiency can lead to subacute combined degeneration of the spinal cord, with demyelination of the dorsal and lateral columns most often occurring in the cervical and thoracic regions.^16,17 This spinal cord degeneration can cause paresthesia, muscle spasticity, and ataxia.¹⁶

When there is a macrocytic anemia, but the B₁₂ or folate level is only borderline low, additional tests should be performed to help distinguish between B₁₂ and folate deficiency. Both B₁₂ and folate deficiencies can cause elevated homocysteine levels.¹³ Clinically significant B₁₂ deficiency causes elevation of methylmalonic acid (MMA), whereas folate deficiency does not.^13,14 Elevation of MMA can be very sensitive for B₁₂ deficiency but lacks specificity in certain situations, such as pregnancy, renal insufficiency, and advanced age.^13,14

Treatment of vitamin B₁₂ and folate deficiencies with supplementation prevents progression of the disease, and has the potential to relieve most of the symptoms. Oral, sublingual, or parenteral vitamin B₁₂ or oral folate supplements can be started in the primary care setting once the provider has identified whether the patient is B₁₂ deficient, folate deficient, or both.

The vitamin B₁₂ dose used for deficiency-induced macrocytic anemia depends on the cause—for example, a temporary condition such as pregnancy versus a lifelong disorder such as pernicious anemia.¹³ The usual oral dosing regimen is 2 mg/d; if intramuscular injections are used, 50 to 100 mcg are given daily for a week, followed by weekly injections for a month, and then monthly injections of 1 mg for life, if necessary.¹³ Bone marrow response to supplemental B₁₂ is very rapid, with increased reticulocyte counts seen within four or five days.¹³

The usual dose for oral folic acid is 1 mg/d as needed.¹³ Folic acid can be given for folate deficiency only if the vitamin B₁₂ level is normal. Giving folate to a patient with untreated vitamin B₁₂ deficiency can potentially worsen subacute combined degeneration of the spinal cord.^13,16

NORMOCYTIC ANEMIA

In normocytic anemia, the hemoglobin is low but the MCV is normal (see Figure).¹ The history and physical exam should provide clues about whether the underlying cause of the anemia requires emergent (eg, active bleeding) or nonemergent (eg, anemia of chronic disease) management. Some of the causes of normocytic anemia are active bleeding, pregnancy, malnutrition, renal failure, chronic disease, hemolytic disorders, hypersplenism, congenital disorders, endocrine disorders, infection, and primary bone marrow disorders.^1,5 Expanded plasma volume, as seen in pregnancy and overhydration, can also cause normocytic anemia.⁵ If gastrointestinal bleeding is suspected or the patient reports dark, tarry stools consistent with melena, fecal occult blood testing should be done. A positive result strongly supports gastrointestinal bleeding as the cause of the anemia.¹⁸

The reticulocyte count can also be helpful in identifying the cause of this type of anemia. A normocytic anemia with a normal reticulocyte and normal RDW count is usually related to chronic disease.^1,10 For example, chronic kidney disease (CKD) is associated with decreased EPO production due to impaired renal function, which leads to reduced erythropoiesis. Decreased EPO prevents the bone marrow from making red blood cells, resulting in anemia. However, a normocytic anemia with an elevated reticulocyte count points to bleeding or hemolysis, as the reticulosis shows that the bone marrow is increasing red cell production to make up for the lost red cells.⁵

Additional diagnostic laboratory testing for patients with normocytic anemia may involve, for example, creatinine and blood urea nitrogen for patients with CKD, prothrombin time with an INR and liver function tests for patients with liver disease, and urine human chorionic gonadotropin if pregnancy is suspected.

For patients with an infection that is causing severe hemolysis (eg, sepsis due to a ß-hemolytic streptococcal infection), blood cultures should be drawn.⁵ If red blood cell destruction due to an artificial cardiac valve or an autoimmune disorder is suspected as the cause of the anemia, a hematology consult is needed.¹ Anemia caused by disseminated intravascular coagulation or thrombotic thrombocytopenic purpura resulting in hemolysis are usually emergent conditions that require immediate intervention, including hospitalization and management by a hematologist.¹

PATIENT EDUCATION

Patients and any accompanying family members should be educated about the signs and symptoms of anemia, the diagnostic testing and treatment regimens specific to their anemia, and medication compliance issues.

For instance, patients who abuse alcohol often have both vitamin B₁₂ and folate deficiencies. If the macrocytosis is caused by alcohol intake, then the provider should educate the patient on the importance of alcohol abstention, as well as refer the patient for rehabilitation and psychologic counseling, as needed. These patients can sometimes recover from macrocytic anemia simply by stopping alcohol intake and improving their nutrition.¹⁹ Patients with microcytosis due to iron deficiency anemia should be advised about the importance of good nutrition and compliance with iron supplementation.

Repeat CBCs and a follow-up patient history and physical exam will help the provider assess whether the anemia is resolving. Individualized plans that target the specific type of anemia identified, as well as its underlying cause, are key to successful treatment.

CONCLUSION

When managing a patient with anemia, providers must define the type of anemia present and identify its underlying cause before starting treatment. Clues from the patient’s history, physical exam, and CBC can help isolate the cause of anemia. The MCV is the most helpful of the red blood cell indices because it allows the provider to classify the anemia as microcytic, macrocytic, or normocytic.

In cases in which the anemia is acute or ­severe—or in which the patient remains anemic even after being treated by the primary care provider—referral to a specialist is ­appropriate.

CE/CME No: CR-1708

PROGRAM OVERVIEW
Earn credit by reading this article and successfully completing the posttest and evaluation. Successful completion is defined as a cumulative score of at least 70% correct.

EDUCATIONAL OBJECTIVES
• Discuss the importance of diagnosing the type of anemia in order to provide appropriate treatment.
• Describe how the complete blood count and its indices are used to initially determine if an anemia is microcytic, normocytic, or macrocytic.
• List the more common causes of microcytic, normocytic, and macrocytic anemia.
• Discuss addictional laboratory tests that may be used to further assess the cause of anemia.

FACULTY
Jean O’Neil is an Assistant Professor and Coordinator of the Adult Gerontology Acute Care Nurse Practitioner Program in the Patricia A. Chin School of Nursing at California State University, Los Angeles.

ACCREDITATION STATEMENT

This program has been reviewed and is approved for a maximum of 1.0 hour of American Academy of Physician Assistants (AAPA) Category 1 CME credit by the Physician Assistant Review Panel. [NPs: Both ANCC and the AANP Certification Program recognize AAPA as an approved provider of Category 1 credit.] Approval is valid through July 31, 2018.

Article begins on next page >>

Anemia affects more than 3 million people in the United States, making it a common problem in primary care practices. Once anemia is detected, clinicians must define the type and identify its underlying cause prior to initiating treatment. In most cases, the cause can be determined using information from the patient history, physical exam, and complete blood count.

Anemia is commonly identified during routine physical exams and laboratory testing.^1-3 However, treating anemia can present a challenge for the primary care provider if the immediate cause is not apparent. Iron deficiency is a leading cause of anemia, but simply prescribing an iron supplement without determining the type or the cause of the anemia is not appropriate. Anemia that is misdiagnosed or goes untreated can be associated with a worse prognosis, as well as increased health care costs.⁴

Primary care providers often manage patients with common types of anemia and refer patients with severe or complex anemia to specialists for further testing and treatment. The most commonly used and cost-effective diagnostic tool for anemia is the complete blood count (CBC).^2-6 The CBC provides details that can help the provider determine the type of anemia present, which in turn guides proper diagnostic testing and treatment.

EPIDEMIOLOGY

Anemia involves a reduction in the number of circulating red blood cells, the blood hemoglobin content, or the hematocrit, which leads to impaired delivery of oxygen to the body. Anemia affects more than 2 billion people worldwide, with iron deficiency the most common cause.⁷ Other leading nutritional causes of anemia include vitamin B₁₂ and folate deficiency.^4,7 Approximately 3 to 4 million Americans have anemia in some form, and it affects about 6.6% of men and 12.4% of women.^5,8 The prevalence of anemia increases with age. Approximately 11% of men and 10% of women ages 65 or older have anemia, and in men ages 85 or older, prevalence of 20% to 44% has been reported.^1,4 Anemia is present in about 3.5% of patients with chronic disease, but only 15% of them receive treatment.⁴

PATHOPHYSIOLOGY

Blood is composed of water-based plasma (54%), white blood cells and platelets (1%), and red blood cells (45%).⁵ Hemoglobin, the primary protein of the red blood cell, binds oxygen from the lungs and transports it to the rest of the body. Oxygen is then exchanged for carbon dioxide, which is carried back to the lungs to be exhaled.

Hemoglobin is made up of four globin chains, each containing an iron ion held in a porphyrin ring known as a heme group.⁵ When the body detects low tissue oxygen, the endothelial cells in the kidneys secrete the hormone erythropoietin (EPO), which stimulates the bone marrow to increase red cell production.⁵ This feedback loop can be interrupted by renal failure or chronic disease.⁴ In addition, bone marrow cannot produce enough red blood cells if there are insufficient levels of iron, amino acids, protein, carbohydrates, lipids, folate, and vitamin B₁₂.⁵ Toxins (eg, lead), some types of cancer (eg, lymphoma), or even common infections (eg, pneumonia) can suppress the bone marrow, causing anemia. The more severe the anemia, the more likely oxygen transport will be compromised and organ failure will ensue.

Mutations affecting the genes that encode the globin chains within hemoglobin can cause one of the more than 600 known hemoglobinopathies (genetic defects of hemoglobin structure), such as sickle cell disease and thalassemias.^5,9 While it is important to identify and treat patients with hemoglobinopathies, most anemias have other causes, such as iron deficiency, chronic disease, bone marrow defects, B₁₂ deficiency, renal failure, medications, alcoholism, pregnancy, nutritional intake problems, gastrointestinal malabsorption, and active or recent history of blood loss.^5,10

CLINICAL PRESENTATION

There are several signs and symptoms that should lead the primary care provider to suspect anemia (see Table 1).^5,6 The severity of these symptoms can vary from mild to very serious. Severe anemia can lead to organ failure and death. However, most patients with anemia are asymptomatic, and anemia is typically detected incidentally during laboratory testing.^1,2

Once anemia is confirmed, the evaluation focuses on diagnosing its underlying cause. It should include a thorough patient history and review of systems to ascertain whether the patient has symptoms such as increased fatigue, palpitations, gastrointestinal distress, weakness, or dizziness.

If the provider has access to past CBC results, a comparison of the current and previous results will help determine whether the anemia is acute or chronic. Anemia caused by acute conditions, such as a suspicion of blood loss or bone marrow suppression, must be attended to immediately. A patient with chronic anemia should be carefully monitored and may need follow-up for ongoing treatment. While a provider has more time to work up a patient with chronic anemia, the causes may not be as straight­forward.

DIAGNOSIS AND CLASSIFICATION

Anemia in adults is defined as hemoglobin less than 13 g/dL in males and 12 g/dL in females.⁶ The hemoglobin is part of the complete blood cell report, which also includes the white blood cell count (WBC), red blood cell count (RBC), hematocrit, platelet count, and indices.

When investigating the underlying cause of anemia, the most useful parts of the CBC are the hemoglobin and the mean corpuscular volume (MCV; see Table 2).^6,10 The MCV is the average volume of red cells in a specimen. This parameter is used to classify the anemia as microcytic (MCV < 80 fL), normocytic (MCV 80-100 fL), or macrocytic (MCV > 100 fL), which helps to narrow the differential diagnosis and guide any further testing (see Figure).^5,6,10

It is important to note that the normal ranges of the CBC parameters differ based on race, with persons of African ancestry having lower normal hemoglobin levels than persons of Caucasian ancestry.¹⁰ In addition, laboratories may have slightly different normal values for the CBC based on the equipment they utilize. Therefore, providers must follow their laboratory’s parameters, as well as adjust for the patient’s gender, age, and ethnicity.¹⁰

Microcytic Anemia

Iron deficiency

In microcytic anemia, the RBCs are smaller than average (MCV < 80 fL), as well as hypochromic due to lack of hemoglobin.⁹ Iron deficiency is the most common cause of microcytic anemia worldwide.^11,12 Therefore, when a patient has microcytic anemia, a serum ferritin needs to be ordered. Further testing of total iron-binding capacity (TIBC), transferrin saturation, serum iron, and serum receptor levels may be helpful if the ferritin level is between 46-99 ng/mL and anemia due to iron deficiency is not confirmed (see Table 2).¹²

In iron deficiency anemia, serum ferritin and serum iron levels are low due to lack of iron, but serum TIBC is high.⁶ The elevated TIBC reflects increased synthesis of transferrin by the liver as it attempts to compensate for the patient’s low serum iron level.⁹ Since iron levels are controlled by absorption rather than excretion, iron is essentially only depleted from the body through blood loss.¹² Therefore, an adult patient who is iron deficient has lost more iron through blood loss than was replaced through nutritional intake and gastrointestinal absorption. In children, increased growth-related iron requirements combined with poor nutritional intake of iron-rich foods is an additional mechanism for iron deficiency.¹¹

Iron deficiency in all men and nonmenstruating women should always be worked up for possible blood loss due to abnormal (eg, gastrointestinal) bleeding or nonphysiologic (eg, poor dietary intake of iron) causes.^11,12 Additional clinical findings associated with chronic iron deficiency include glossitis, angular stomatitis, and koilonych­ias (spoon-shaped nails).¹²

If the nutritional problem is corrected or the source of bleeding is controlled, treatment with oral or intravenous iron supplements should result in improved serum hemoglobin and reticulocyte counts.¹³ In the primary care setting, ferrous sulfate 325 mg, which provides 65 mg of elemental iron per tablet, orally three times daily is recommended for adults.¹³ This gives the patient the recommended dose of approximately 200 mg of elemental iron. Repeat hemoglobin and iron studies should be conducted again in three to six months.^12,13

If the patient’s iron deficiency anemia does not improve after oral iron therapy, there may be a source of blood loss the provider missed or a problem with malabsorption of iron, which can be seen in those who have undergone gastric bypass surgery or who have inflammatory bowel disease.¹³ Such patients should be referred to a specialist, such as a gastroenterologist, for further evaluation.

Thalassemia

Microcytic anemia with normal or elevated serum iron and normal-to-increased serum ferritin can be seen in patients with a type of thalassemia (see Figure).² Thalassemias are inherited blood disorders that reduce hemoglobin production, leading to microcytosis; they are more common in those of Mediterranean, African, and Southeast Asian descent.² Red cells in patients with a form of thalassemia are usually very small (microcytic) and have normal or elevated red cell distribution width (RDW).¹⁰

Moderate and severe forms of thalassemia can cause anemia. However, thalassemia syndromes that can cause severe (transfusion-dependent) anemia are usually diagnosed in childhood.⁹ Patients with one of the minor forms of thalassemia typically need minimal to no treatment.⁵ A patient with significant anemia suspicious for thalassemia should undergo hemoglobin electrophoresis testing to confirm the diagnosis and to determine the type of thalassemia.² Typically, hemoglobin electrophoresis is normal in α thalassemia and is abnormal in ß thalassemia, as well as other forms of thalassemia. Referral to a hematologist for interpretation of these results and for further evaluation is appropriate.¹⁰

Chronic disease

If the patient has microcytic anemia and is not iron deficient or does not have thalassemia, then anemia related to a chronic disease should be considered.⁵ In such cases, the provider should order a reticulocyte count, which reveals how the bone marrow is responding to the anemia.⁵ Reticulocytes are immature red cells that have just been released from the bone marrow into the blood stream. The bone marrow increases the release of these cells in response to anemia.⁶

Any condition that stimulates reticulocyte production or prevents the bone marrow from producing reticulocytes will result in abnormal values (see Table 3). A normal reticulocyte count, expressed as the reticulocyte production index, is between 0.5% and 1.5%.⁵ The reticulocyte count is low in iron deficiency anemia and diseases that lead to decreased bone marrow production.^5,6 Bone marrow suppression can occur in the context of chronic disease, infection, or inflammation. Malignancies are a less common cause for chronic disease microcytic anemia.⁶

If the cause of the decreased reticulocyte count is iron deficiency anemia, then treatment with iron supplementation should result in an increased reticulocyte count within one week.¹³ The primary care provider works in conjunction with the specialist to monitor the patient’s anemia when it is due to chronic disease or malignancy.

MACROCYTIC ANEMIA

In macrocytic anemia, the RBCs are larger than normal (MCV > 100 fL). This form of anemia is usually caused by vitamin B₁₂ and folate deficiency, but it can also result from alcoholism, certain medications (eg, chemotherapy, antivirals), bone marrow disorders (eg, leukemia), and liver disease (eg, cirrhosis; see Figure).^5,14 Common medications that can cause macrocytosis include the antiseizure drug phenytoin, the antibiotics trimethoprim/sulfamethoxazole and nitrofurantoin, the disease-modifying antirheumatic drug sulfasalazine, and immunosuppressants such as azathioprine.^14,15 Antiviral agents, such as reverse transcriptase inhibitors (eg, zidovudine) used to treat HIV infection, can also cause macrocytosis with or without anemia.^6,14

Macrocytic anemias caused by low serum levels of B₁₂ and folate usually reflect problems with gastrointestinal malabsorption. For example, gastric bypass or Crohn disease can lead to malabsorption of vitamin B₁₂ and increase a patient’s risk for macrocytic anemia.¹³

Vitamin B₁₂ deficiency occurs in patients with pernicious anemia because they are missing intrinsic factor, which is necessary to facilitate B₁₂ absorption in the ileum.¹⁰ Low vitamin B₁₂ and folate levels also can result from inadequate dietary intake, although this is rare in the United States due to mandatory fortification of certain foods. A diet low in fresh vegetables is the leading cause of folate deficiency. While folate deficiency related to poor nutritional intake can be seen in all age groups, vitamin B₁₂ deficiency more frequently affects the elderly or persons following a strict vegan diet.¹⁴

In addition to the fatigue and pallor associated with macrocytic anemia, patients with vitamin B₁₂ deficiency may also have a smooth tongue, peripheral neuropathy, and edema.^5,14 Severe vitamin B₁₂ deficiency can lead to subacute combined degeneration of the spinal cord, with demyelination of the dorsal and lateral columns most often occurring in the cervical and thoracic regions.^16,17 This spinal cord degeneration can cause paresthesia, muscle spasticity, and ataxia.¹⁶

When there is a macrocytic anemia, but the B₁₂ or folate level is only borderline low, additional tests should be performed to help distinguish between B₁₂ and folate deficiency. Both B₁₂ and folate deficiencies can cause elevated homocysteine levels.¹³ Clinically significant B₁₂ deficiency causes elevation of methylmalonic acid (MMA), whereas folate deficiency does not.^13,14 Elevation of MMA can be very sensitive for B₁₂ deficiency but lacks specificity in certain situations, such as pregnancy, renal insufficiency, and advanced age.^13,14

Treatment of vitamin B₁₂ and folate deficiencies with supplementation prevents progression of the disease, and has the potential to relieve most of the symptoms. Oral, sublingual, or parenteral vitamin B₁₂ or oral folate supplements can be started in the primary care setting once the provider has identified whether the patient is B₁₂ deficient, folate deficient, or both.

The vitamin B₁₂ dose used for deficiency-induced macrocytic anemia depends on the cause—for example, a temporary condition such as pregnancy versus a lifelong disorder such as pernicious anemia.¹³ The usual oral dosing regimen is 2 mg/d; if intramuscular injections are used, 50 to 100 mcg are given daily for a week, followed by weekly injections for a month, and then monthly injections of 1 mg for life, if necessary.¹³ Bone marrow response to supplemental B₁₂ is very rapid, with increased reticulocyte counts seen within four or five days.¹³

The usual dose for oral folic acid is 1 mg/d as needed.¹³ Folic acid can be given for folate deficiency only if the vitamin B₁₂ level is normal. Giving folate to a patient with untreated vitamin B₁₂ deficiency can potentially worsen subacute combined degeneration of the spinal cord.^13,16

NORMOCYTIC ANEMIA

In normocytic anemia, the hemoglobin is low but the MCV is normal (see Figure).¹ The history and physical exam should provide clues about whether the underlying cause of the anemia requires emergent (eg, active bleeding) or nonemergent (eg, anemia of chronic disease) management. Some of the causes of normocytic anemia are active bleeding, pregnancy, malnutrition, renal failure, chronic disease, hemolytic disorders, hypersplenism, congenital disorders, endocrine disorders, infection, and primary bone marrow disorders.^1,5 Expanded plasma volume, as seen in pregnancy and overhydration, can also cause normocytic anemia.⁵ If gastrointestinal bleeding is suspected or the patient reports dark, tarry stools consistent with melena, fecal occult blood testing should be done. A positive result strongly supports gastrointestinal bleeding as the cause of the anemia.¹⁸

The reticulocyte count can also be helpful in identifying the cause of this type of anemia. A normocytic anemia with a normal reticulocyte and normal RDW count is usually related to chronic disease.^1,10 For example, chronic kidney disease (CKD) is associated with decreased EPO production due to impaired renal function, which leads to reduced erythropoiesis. Decreased EPO prevents the bone marrow from making red blood cells, resulting in anemia. However, a normocytic anemia with an elevated reticulocyte count points to bleeding or hemolysis, as the reticulosis shows that the bone marrow is increasing red cell production to make up for the lost red cells.⁵

Additional diagnostic laboratory testing for patients with normocytic anemia may involve, for example, creatinine and blood urea nitrogen for patients with CKD, prothrombin time with an INR and liver function tests for patients with liver disease, and urine human chorionic gonadotropin if pregnancy is suspected.

For patients with an infection that is causing severe hemolysis (eg, sepsis due to a ß-hemolytic streptococcal infection), blood cultures should be drawn.⁵ If red blood cell destruction due to an artificial cardiac valve or an autoimmune disorder is suspected as the cause of the anemia, a hematology consult is needed.¹ Anemia caused by disseminated intravascular coagulation or thrombotic thrombocytopenic purpura resulting in hemolysis are usually emergent conditions that require immediate intervention, including hospitalization and management by a hematologist.¹

PATIENT EDUCATION

Patients and any accompanying family members should be educated about the signs and symptoms of anemia, the diagnostic testing and treatment regimens specific to their anemia, and medication compliance issues.

For instance, patients who abuse alcohol often have both vitamin B₁₂ and folate deficiencies. If the macrocytosis is caused by alcohol intake, then the provider should educate the patient on the importance of alcohol abstention, as well as refer the patient for rehabilitation and psychologic counseling, as needed. These patients can sometimes recover from macrocytic anemia simply by stopping alcohol intake and improving their nutrition.¹⁹ Patients with microcytosis due to iron deficiency anemia should be advised about the importance of good nutrition and compliance with iron supplementation.

Repeat CBCs and a follow-up patient history and physical exam will help the provider assess whether the anemia is resolving. Individualized plans that target the specific type of anemia identified, as well as its underlying cause, are key to successful treatment.

CONCLUSION

When managing a patient with anemia, providers must define the type of anemia present and identify its underlying cause before starting treatment. Clues from the patient’s history, physical exam, and CBC can help isolate the cause of anemia. The MCV is the most helpful of the red blood cell indices because it allows the provider to classify the anemia as microcytic, macrocytic, or normocytic.

In cases in which the anemia is acute or ­severe—or in which the patient remains anemic even after being treated by the primary care provider—referral to a specialist is ­appropriate.

EVIDENCE SUMMARY

A 2007 Cochrane review on scabies treatment identified 11 trials that evaluated permethrin for treating scabies.¹ In 2 trials, 140 patients were randomized to receive either 200 mcg/kg of oral ivermectin or overnight application of 5% topical permethrin. Topical permethrin was superior to oral ivermectin with failure rates at 2 weeks of 8% and 39%, respectively (number needed to treat [NNT]=4; risk ratio [RR]=4.61; 95% confidence interval [CI], 2.07-10.26).

Two trials compared 5% topical permethrin with 10% topical crotamiton in 194 patients with follow-up at 28 days. Permethrin was superior to crotamiton with failure rates of 6% and 26%, respectively (NNT=6; RR=0.24; 95% CI, 0.10-0.55).

Five trials with 753 patients compared topical permethrin, 2.5% to 3.5%, with topical 1% lindane, but heterogeneity precluded pooling all the studies. In the 3 studies (554 patients) that were comparable, topical 3.5% permethrin was superior to lindane after a single application of each with failure rates of 9% and 15%, respectively (NNT=17; RR=0.59; 95% CI, 0.37-0.95).

Two trials that compared permethrin with topical benzyl benzoate (53 patients) and natural synergized pyrethrins (40 patients) showed no difference in treatment failures, but the trials were small and lacked sufficient statistical power.

Four additional studies included in the review compared crotamiton with lindane (100 patients), lindane with sulfur (68 patients), benzyl benzoate with sulfur (158 patients), and benzyl benzoate with natural synergized pyrethrins (240 patients). None demonstrated superiority, but all were small studies.¹ A single small trial of 55 patients that compared oral ivermectin 200 mcg/kg with placebo showed failure rates at one week of 21% and 85%, respectively (NNT=2; RR=0.24; 95% CI, 0.12-0.51).¹

Topical permethrin vs oral ivermectin

A 2014 systematic review of 5 studies included 2 new studies done after the 2007 Cochrane review.² The new RCTs compared a single application of 5% topical permethrin with a single dose or 2 doses of oral ivermectin given 2 weeks apart. No statistically significant differences were found in these studies.² Both underpowered studies favored topical permethrin, however.

The CDC and the European Guideline for the Management of Scabies both recommend topical permethrin as first-line therapy for classical scabies.

The P value was .42 in one study of 242 adults and children, and this trial showed a clinical cure rate at 2 weeks of 93% using topical permethrin vs 86% using oral ivermectin.²

The other study of 120 adults and children didn’t report a P value or identify statistically significant differences between topical permethrin and oral ivermectin.² This study reported a clinical cure rate of 87% with topical permethrin, 78% with a single dose of oral ivermectin, and 67% with 2 doses of oral ivermectin 2 weeks apart.²

Ivermectin may control endemic scabies better than permethrin

A 2015 randomized controlled trial with 2051 patients compared mass treatments in a scabies-endemic population in Fiji.³ The trial had 3 arms: a standard-care group treated with 5% topical permethrin if symptoms were present and retreated at 2 weeks if symptoms persisted; a permethrin group in which all participants, whether infected or not, received 5% permethrin followed by a second dose at 7 to 14 days if symptoms persisted; and an oral ivermectin group in which participants were treated with 200 mcg/kg, repeated in 7 to 14 days for those with baseline scabies.

At 12 months, the relative risk reductions were 94% (95% CI, 83%-100%) for the ivermectin group, 62% (95% CI, 49%-75%) for the permethrin group, and 49% (95% CI, 37%-60%) for the standard-care group.³ The study had multiple limitations, and all groups were permitted to receive standard care at any time during the 12-month follow-up period. Nevertheless, the findings suggest that endemic scabies control with ivermectin may be superior to topical permethrin.

RECOMMENDATIONS

The Centers for Disease Control and Prevention (CDC)⁴ and the European Guideline for the Management of Scabies⁵ both recommend topical permethrin as first-line therapy for classical scabies and note that oral ivermectin may be safe and effective but isn’t licensed for scabies treatment in most countries. Ivermectin isn’t approved by the United States Food and Drug Administration for treating scabies.

The CDC recommendations note that the safety of ivermectin in children weighing less than 15 kg and pregnant women hasn’t been established.⁴

EVIDENCE SUMMARY

A 2007 Cochrane review on scabies treatment identified 11 trials that evaluated permethrin for treating scabies.¹ In 2 trials, 140 patients were randomized to receive either 200 mcg/kg of oral ivermectin or overnight application of 5% topical permethrin. Topical permethrin was superior to oral ivermectin with failure rates at 2 weeks of 8% and 39%, respectively (number needed to treat [NNT]=4; risk ratio [RR]=4.61; 95% confidence interval [CI], 2.07-10.26).

Two trials compared 5% topical permethrin with 10% topical crotamiton in 194 patients with follow-up at 28 days. Permethrin was superior to crotamiton with failure rates of 6% and 26%, respectively (NNT=6; RR=0.24; 95% CI, 0.10-0.55).

Five trials with 753 patients compared topical permethrin, 2.5% to 3.5%, with topical 1% lindane, but heterogeneity precluded pooling all the studies. In the 3 studies (554 patients) that were comparable, topical 3.5% permethrin was superior to lindane after a single application of each with failure rates of 9% and 15%, respectively (NNT=17; RR=0.59; 95% CI, 0.37-0.95).

Two trials that compared permethrin with topical benzyl benzoate (53 patients) and natural synergized pyrethrins (40 patients) showed no difference in treatment failures, but the trials were small and lacked sufficient statistical power.

Four additional studies included in the review compared crotamiton with lindane (100 patients), lindane with sulfur (68 patients), benzyl benzoate with sulfur (158 patients), and benzyl benzoate with natural synergized pyrethrins (240 patients). None demonstrated superiority, but all were small studies.¹ A single small trial of 55 patients that compared oral ivermectin 200 mcg/kg with placebo showed failure rates at one week of 21% and 85%, respectively (NNT=2; RR=0.24; 95% CI, 0.12-0.51).¹

Topical permethrin vs oral ivermectin

A 2014 systematic review of 5 studies included 2 new studies done after the 2007 Cochrane review.² The new RCTs compared a single application of 5% topical permethrin with a single dose or 2 doses of oral ivermectin given 2 weeks apart. No statistically significant differences were found in these studies.² Both underpowered studies favored topical permethrin, however.

The CDC and the European Guideline for the Management of Scabies both recommend topical permethrin as first-line therapy for classical scabies.

The P value was .42 in one study of 242 adults and children, and this trial showed a clinical cure rate at 2 weeks of 93% using topical permethrin vs 86% using oral ivermectin.²

The other study of 120 adults and children didn’t report a P value or identify statistically significant differences between topical permethrin and oral ivermectin.² This study reported a clinical cure rate of 87% with topical permethrin, 78% with a single dose of oral ivermectin, and 67% with 2 doses of oral ivermectin 2 weeks apart.²

Ivermectin may control endemic scabies better than permethrin

A 2015 randomized controlled trial with 2051 patients compared mass treatments in a scabies-endemic population in Fiji.³ The trial had 3 arms: a standard-care group treated with 5% topical permethrin if symptoms were present and retreated at 2 weeks if symptoms persisted; a permethrin group in which all participants, whether infected or not, received 5% permethrin followed by a second dose at 7 to 14 days if symptoms persisted; and an oral ivermectin group in which participants were treated with 200 mcg/kg, repeated in 7 to 14 days for those with baseline scabies.

At 12 months, the relative risk reductions were 94% (95% CI, 83%-100%) for the ivermectin group, 62% (95% CI, 49%-75%) for the permethrin group, and 49% (95% CI, 37%-60%) for the standard-care group.³ The study had multiple limitations, and all groups were permitted to receive standard care at any time during the 12-month follow-up period. Nevertheless, the findings suggest that endemic scabies control with ivermectin may be superior to topical permethrin.

RECOMMENDATIONS

The Centers for Disease Control and Prevention (CDC)⁴ and the European Guideline for the Management of Scabies⁵ both recommend topical permethrin as first-line therapy for classical scabies and note that oral ivermectin may be safe and effective but isn’t licensed for scabies treatment in most countries. Ivermectin isn’t approved by the United States Food and Drug Administration for treating scabies.

The CDC recommendations note that the safety of ivermectin in children weighing less than 15 kg and pregnant women hasn’t been established.⁴

EVIDENCE SUMMARY

A 2007 Cochrane review on scabies treatment identified 11 trials that evaluated permethrin for treating scabies.¹ In 2 trials, 140 patients were randomized to receive either 200 mcg/kg of oral ivermectin or overnight application of 5% topical permethrin. Topical permethrin was superior to oral ivermectin with failure rates at 2 weeks of 8% and 39%, respectively (number needed to treat [NNT]=4; risk ratio [RR]=4.61; 95% confidence interval [CI], 2.07-10.26).

Two trials compared 5% topical permethrin with 10% topical crotamiton in 194 patients with follow-up at 28 days. Permethrin was superior to crotamiton with failure rates of 6% and 26%, respectively (NNT=6; RR=0.24; 95% CI, 0.10-0.55).

Five trials with 753 patients compared topical permethrin, 2.5% to 3.5%, with topical 1% lindane, but heterogeneity precluded pooling all the studies. In the 3 studies (554 patients) that were comparable, topical 3.5% permethrin was superior to lindane after a single application of each with failure rates of 9% and 15%, respectively (NNT=17; RR=0.59; 95% CI, 0.37-0.95).

Two trials that compared permethrin with topical benzyl benzoate (53 patients) and natural synergized pyrethrins (40 patients) showed no difference in treatment failures, but the trials were small and lacked sufficient statistical power.

Four additional studies included in the review compared crotamiton with lindane (100 patients), lindane with sulfur (68 patients), benzyl benzoate with sulfur (158 patients), and benzyl benzoate with natural synergized pyrethrins (240 patients). None demonstrated superiority, but all were small studies.¹ A single small trial of 55 patients that compared oral ivermectin 200 mcg/kg with placebo showed failure rates at one week of 21% and 85%, respectively (NNT=2; RR=0.24; 95% CI, 0.12-0.51).¹

Topical permethrin vs oral ivermectin

A 2014 systematic review of 5 studies included 2 new studies done after the 2007 Cochrane review.² The new RCTs compared a single application of 5% topical permethrin with a single dose or 2 doses of oral ivermectin given 2 weeks apart. No statistically significant differences were found in these studies.² Both underpowered studies favored topical permethrin, however.

The CDC and the European Guideline for the Management of Scabies both recommend topical permethrin as first-line therapy for classical scabies.

The P value was .42 in one study of 242 adults and children, and this trial showed a clinical cure rate at 2 weeks of 93% using topical permethrin vs 86% using oral ivermectin.²

The other study of 120 adults and children didn’t report a P value or identify statistically significant differences between topical permethrin and oral ivermectin.² This study reported a clinical cure rate of 87% with topical permethrin, 78% with a single dose of oral ivermectin, and 67% with 2 doses of oral ivermectin 2 weeks apart.²

Ivermectin may control endemic scabies better than permethrin

A 2015 randomized controlled trial with 2051 patients compared mass treatments in a scabies-endemic population in Fiji.³ The trial had 3 arms: a standard-care group treated with 5% topical permethrin if symptoms were present and retreated at 2 weeks if symptoms persisted; a permethrin group in which all participants, whether infected or not, received 5% permethrin followed by a second dose at 7 to 14 days if symptoms persisted; and an oral ivermectin group in which participants were treated with 200 mcg/kg, repeated in 7 to 14 days for those with baseline scabies.

At 12 months, the relative risk reductions were 94% (95% CI, 83%-100%) for the ivermectin group, 62% (95% CI, 49%-75%) for the permethrin group, and 49% (95% CI, 37%-60%) for the standard-care group.³ The study had multiple limitations, and all groups were permitted to receive standard care at any time during the 12-month follow-up period. Nevertheless, the findings suggest that endemic scabies control with ivermectin may be superior to topical permethrin.

RECOMMENDATIONS

The Centers for Disease Control and Prevention (CDC)⁴ and the European Guideline for the Management of Scabies⁵ both recommend topical permethrin as first-line therapy for classical scabies and note that oral ivermectin may be safe and effective but isn’t licensed for scabies treatment in most countries. Ivermectin isn’t approved by the United States Food and Drug Administration for treating scabies.

The CDC recommendations note that the safety of ivermectin in children weighing less than 15 kg and pregnant women hasn’t been established.⁴

Although the concept of the living will was first proposed in 1969,¹ the idea caught on slowly. In fact, the first scholarly article discussing the topic didn’t appear until 16 years later.²

In contrast, an informal search of PubMed reveals that at least 38 articles on advance directives and end-of-life care have been published during the first 7 months of 2017. And a feature article in this month’s issue of JFP makes one more. Why is there such strong interest now in an issue that seldom arose when I began practice in 1978?

More complex, less personalized medicine. As medical care has become more sophisticated, there is a great deal more we can do to keep people alive as they approach the end of life, and a great many more decisions to be made.

Now, most dying hospitalized patients are cared for by hospitalists who may be meeting the patient for the first time.

Additionally, people are much less likely today to be cared for in their dying days by a family physician who knows them, their wishes, and their family well. In my early years in small-town practice, I was present when my patients were dying, and I usually knew their family members. Family meetings were easy to arrange, and we quickly came to a consensus about what to do and what not to do. If I was not available, one of my practice partners was. We cared for our patients in the office, nursing home, and hospital. Now, most dying hospitalized patients are cared for by hospitalists who may be meeting the patient for the first time.

Getting more people to participate. Consequently, it is important to understand patients’ wishes for end-of-life care and to document those wishes in writing, using things like a POLST (Physician Orders for Life-Sustaining Treatment) form. Although randomized trials support the value of advance care planning, especially in primary care settings,^3,4 two-thirds of Americans have not completed an advance directive.⁵ Rolnick suggests we “delegalize” the process to remove barriers and make it easier for people to execute such documents and integrate them into health care systems.⁶

Make it part of your office routine. A 70-year-old patient of mine with advanced COPD arrived at his office visit last month with advance directive and POLST forms in hand. We had an excellent, frank conversation, spiced with humor that he supplied, about his wishes for end-of-life care. Just like so many other tasks that we must squeeze into our busy schedules, this is one that we should hard-wire into our office systems and routines.

Although the concept of the living will was first proposed in 1969,¹ the idea caught on slowly. In fact, the first scholarly article discussing the topic didn’t appear until 16 years later.²

In contrast, an informal search of PubMed reveals that at least 38 articles on advance directives and end-of-life care have been published during the first 7 months of 2017. And a feature article in this month’s issue of JFP makes one more. Why is there such strong interest now in an issue that seldom arose when I began practice in 1978?

More complex, less personalized medicine. As medical care has become more sophisticated, there is a great deal more we can do to keep people alive as they approach the end of life, and a great many more decisions to be made.

Now, most dying hospitalized patients are cared for by hospitalists who may be meeting the patient for the first time.

Additionally, people are much less likely today to be cared for in their dying days by a family physician who knows them, their wishes, and their family well. In my early years in small-town practice, I was present when my patients were dying, and I usually knew their family members. Family meetings were easy to arrange, and we quickly came to a consensus about what to do and what not to do. If I was not available, one of my practice partners was. We cared for our patients in the office, nursing home, and hospital. Now, most dying hospitalized patients are cared for by hospitalists who may be meeting the patient for the first time.

Getting more people to participate. Consequently, it is important to understand patients’ wishes for end-of-life care and to document those wishes in writing, using things like a POLST (Physician Orders for Life-Sustaining Treatment) form. Although randomized trials support the value of advance care planning, especially in primary care settings,^3,4 two-thirds of Americans have not completed an advance directive.⁵ Rolnick suggests we “delegalize” the process to remove barriers and make it easier for people to execute such documents and integrate them into health care systems.⁶

Make it part of your office routine. A 70-year-old patient of mine with advanced COPD arrived at his office visit last month with advance directive and POLST forms in hand. We had an excellent, frank conversation, spiced with humor that he supplied, about his wishes for end-of-life care. Just like so many other tasks that we must squeeze into our busy schedules, this is one that we should hard-wire into our office systems and routines.

Although the concept of the living will was first proposed in 1969,¹ the idea caught on slowly. In fact, the first scholarly article discussing the topic didn’t appear until 16 years later.²

In contrast, an informal search of PubMed reveals that at least 38 articles on advance directives and end-of-life care have been published during the first 7 months of 2017. And a feature article in this month’s issue of JFP makes one more. Why is there such strong interest now in an issue that seldom arose when I began practice in 1978?

More complex, less personalized medicine. As medical care has become more sophisticated, there is a great deal more we can do to keep people alive as they approach the end of life, and a great many more decisions to be made.

Now, most dying hospitalized patients are cared for by hospitalists who may be meeting the patient for the first time.

Additionally, people are much less likely today to be cared for in their dying days by a family physician who knows them, their wishes, and their family well. In my early years in small-town practice, I was present when my patients were dying, and I usually knew their family members. Family meetings were easy to arrange, and we quickly came to a consensus about what to do and what not to do. If I was not available, one of my practice partners was. We cared for our patients in the office, nursing home, and hospital. Now, most dying hospitalized patients are cared for by hospitalists who may be meeting the patient for the first time.

Getting more people to participate. Consequently, it is important to understand patients’ wishes for end-of-life care and to document those wishes in writing, using things like a POLST (Physician Orders for Life-Sustaining Treatment) form. Although randomized trials support the value of advance care planning, especially in primary care settings,^3,4 two-thirds of Americans have not completed an advance directive.⁵ Rolnick suggests we “delegalize” the process to remove barriers and make it easier for people to execute such documents and integrate them into health care systems.⁶

Make it part of your office routine. A 70-year-old patient of mine with advanced COPD arrived at his office visit last month with advance directive and POLST forms in hand. We had an excellent, frank conversation, spiced with humor that he supplied, about his wishes for end-of-life care. Just like so many other tasks that we must squeeze into our busy schedules, this is one that we should hard-wire into our office systems and routines.

THE CASE

A 31-year-old woman presented to her obstetrician’s office at 16 weeks’ gestation with a 2-day history of low-grade fever and an erythematous rash measuring 1 x 4 cm on her right groin. She had a medical history of a penicillin allergy (urticaria) and her outdoor activities included gardening and picnicking.

We suspected that she was experiencing an allergic reaction and recommended an antihistamine (diphenhydramine). The patient returned 4 days later with new symptoms including headache, photophobia, neck pain, unilateral large joint pain, and periorbital cellulitis, as well as expansion of her rash. She was afebrile and an examination revealed that the 1 x 4 cm rash on her groin had grown; it was now a demarcated erythematous rash with faint central clearing measuring 5 x 8 cm. Right periorbital erythema and nuchal rigidity were also noted.

Because of her expanding rash and nuchal rigidity, we suspected Lyme meningitis and we referred her to the emergency department. Within 24 hours, the rash had spread to her abdomen, thigh, and wrist, and was consistent with erythema migrans.

Laboratory evaluation revealed an increased number of white bloods cells (13.5 million cells/mcL; normal range 4.5-11.0 million cells/mcL), and an increased number of neutrophils (10.8 million cells/mcL; normal range 1.8-8 million cells/mcL), indicating leukocytosis with a left shift. Lab tests also revealed a low hemoglobin level (10.6 g/dL; normal range 12-16 g/dL) and a mean corpuscular volume of 85.6 fL/red cell (normal range 80-100 fL/red cell), indicating microcytic anemia. A lumbar puncture was negative for disseminated Lyme disease by Gram stain, culture, and polymerase chain reaction.

THE DIAGNOSIS

A diagnosis of Lyme disease was confirmed with a positive Lyme titer serology via an enzyme-linked immunosorbent assay. The rash and other symptoms responded promptly to intravenous ceftriaxone 2 g, and the patient was discharged home on oral cefuroxime 500 mg bid for 14 days.

DISCUSSION

Lyme disease is the most common vector-borne illness in the United States, concentrated heavily in the Northeast and upper Midwest.¹ The most recent information released by the Centers for Disease Control and Prevention (CDC) lists Vermont, Maine, Pennsylvania, Rhode Island, Connecticut, New Jersey, Massachusetts, Delaware, New Hampshire, and Minnesota as the states with the highest incidence of Lyme disease.²

The number of reported cases in the United States has increased over the past 2 decades, from approximately 11,000 in 1995 to about 28,000 in 2015.³ Over the past year, we have seen several cases of Lyme disease in the obstetric population of our own practice.

Prompt treatment is crucial. Pregnant women who are acutely infected with Borrelia burgdorferi (the primary cause of Lyme disease) and do not receive treatment have experienced multiple adverse pregnancy outcomes, including preterm delivery, infants born with rash, and stillbirth.⁴ Additional concern exists for fetal cardiac anomalies, with data showing that there are twice as many cardiac defects in children born to mothers residing in endemic regions.⁵

What animal studies have taught us about Lyme disease

The potential causal relationship between Lyme disease and fetal demise was first studied in 2007. This case report involved the stillbirth of a full-term baby from an acutely infected woman who did not receive treatment. She experienced erythema multiforme 6 weeks prior to delivery.⁶

A fetal echocardiogram is reasonable in pregnant women acutely infected with Lyme disease during the first trimester, given the high potential for fetal cardiac anomalies.

The vast majority of research on Lyme disease in pregnancy comes from work with mice and dogs. These studies confirmed that acute infection with Lyme disease is associated with an increased risk of adverse fetal outcomes, specifically fetal death.⁷

Silver et al further researched the association using murine models in the 1980s. They found that fetal death occurred in 12% of acutely infected mice, compared with none of the mice that were chronically infected.⁷

In 2010, Lakos and Solymosi examined the effects of Lyme disease on pregnancy outcomes in acutely infected women. Seven out of 95 pregnant women acutely infected with B burgdorferi experienced fetal demise, further supporting the association seen in animal experiments.⁸

Treating pregnant patients

Doxycycline and tetracycline, which are routinely used to treat Lyme disease, are not appropriate in the obstetric population. The CDC recommends up to a 3-week course of antibiotics; the standard regimen is amoxicillin 500 mg by mouth tid. For women who are allergic to penicillin, as was the case with our patient, cefuroxime 500 mg by mouth bid is the treatment of choice.⁹

Our patient underwent a detailed ultrasound at 21 weeks, which revealed normal fetal anatomy and no evidence of cardiac malformations. The remainder of her pregnancy was uncomplicated, and she gave birth vaginally at 41 weeks to a baby boy weighing 3700 g.

THE TAKEAWAY

There is a need to increase awareness of Lyme disease in pregnancy on a national level. It is the responsibility of every practitioner caring for obstetric patients in endemic regions to address new-onset rash promptly. There have been cases of women who experienced erythema migrans and arthralgias after exposure to a tick bite, later delivering infants with cardiac anomalies such as atrial and ventricular septal defects.¹⁰ In obstetric patients acutely infected during the first trimester, a fetal echocardiogram is reasonable, given the demonstrated high potential for fetal cardiac anomalies.

Preventing adverse fetal outcomes requires early treatment with antibiotics. The CDC maintains that there have been no life-threatening adverse fetal effects from Lyme disease seen in women who are appropriately treated, as well as no transmission of Lyme disease in the breast milk of lactating mothers.⁹

THE CASE

A 31-year-old woman presented to her obstetrician’s office at 16 weeks’ gestation with a 2-day history of low-grade fever and an erythematous rash measuring 1 x 4 cm on her right groin. She had a medical history of a penicillin allergy (urticaria) and her outdoor activities included gardening and picnicking.

We suspected that she was experiencing an allergic reaction and recommended an antihistamine (diphenhydramine). The patient returned 4 days later with new symptoms including headache, photophobia, neck pain, unilateral large joint pain, and periorbital cellulitis, as well as expansion of her rash. She was afebrile and an examination revealed that the 1 x 4 cm rash on her groin had grown; it was now a demarcated erythematous rash with faint central clearing measuring 5 x 8 cm. Right periorbital erythema and nuchal rigidity were also noted.

Because of her expanding rash and nuchal rigidity, we suspected Lyme meningitis and we referred her to the emergency department. Within 24 hours, the rash had spread to her abdomen, thigh, and wrist, and was consistent with erythema migrans.

Laboratory evaluation revealed an increased number of white bloods cells (13.5 million cells/mcL; normal range 4.5-11.0 million cells/mcL), and an increased number of neutrophils (10.8 million cells/mcL; normal range 1.8-8 million cells/mcL), indicating leukocytosis with a left shift. Lab tests also revealed a low hemoglobin level (10.6 g/dL; normal range 12-16 g/dL) and a mean corpuscular volume of 85.6 fL/red cell (normal range 80-100 fL/red cell), indicating microcytic anemia. A lumbar puncture was negative for disseminated Lyme disease by Gram stain, culture, and polymerase chain reaction.

THE DIAGNOSIS

A diagnosis of Lyme disease was confirmed with a positive Lyme titer serology via an enzyme-linked immunosorbent assay. The rash and other symptoms responded promptly to intravenous ceftriaxone 2 g, and the patient was discharged home on oral cefuroxime 500 mg bid for 14 days.

DISCUSSION

Lyme disease is the most common vector-borne illness in the United States, concentrated heavily in the Northeast and upper Midwest.¹ The most recent information released by the Centers for Disease Control and Prevention (CDC) lists Vermont, Maine, Pennsylvania, Rhode Island, Connecticut, New Jersey, Massachusetts, Delaware, New Hampshire, and Minnesota as the states with the highest incidence of Lyme disease.²

The number of reported cases in the United States has increased over the past 2 decades, from approximately 11,000 in 1995 to about 28,000 in 2015.³ Over the past year, we have seen several cases of Lyme disease in the obstetric population of our own practice.

Prompt treatment is crucial. Pregnant women who are acutely infected with Borrelia burgdorferi (the primary cause of Lyme disease) and do not receive treatment have experienced multiple adverse pregnancy outcomes, including preterm delivery, infants born with rash, and stillbirth.⁴ Additional concern exists for fetal cardiac anomalies, with data showing that there are twice as many cardiac defects in children born to mothers residing in endemic regions.⁵

What animal studies have taught us about Lyme disease

The potential causal relationship between Lyme disease and fetal demise was first studied in 2007. This case report involved the stillbirth of a full-term baby from an acutely infected woman who did not receive treatment. She experienced erythema multiforme 6 weeks prior to delivery.⁶

A fetal echocardiogram is reasonable in pregnant women acutely infected with Lyme disease during the first trimester, given the high potential for fetal cardiac anomalies.

The vast majority of research on Lyme disease in pregnancy comes from work with mice and dogs. These studies confirmed that acute infection with Lyme disease is associated with an increased risk of adverse fetal outcomes, specifically fetal death.⁷

Silver et al further researched the association using murine models in the 1980s. They found that fetal death occurred in 12% of acutely infected mice, compared with none of the mice that were chronically infected.⁷

In 2010, Lakos and Solymosi examined the effects of Lyme disease on pregnancy outcomes in acutely infected women. Seven out of 95 pregnant women acutely infected with B burgdorferi experienced fetal demise, further supporting the association seen in animal experiments.⁸

Treating pregnant patients

Doxycycline and tetracycline, which are routinely used to treat Lyme disease, are not appropriate in the obstetric population. The CDC recommends up to a 3-week course of antibiotics; the standard regimen is amoxicillin 500 mg by mouth tid. For women who are allergic to penicillin, as was the case with our patient, cefuroxime 500 mg by mouth bid is the treatment of choice.⁹

Our patient underwent a detailed ultrasound at 21 weeks, which revealed normal fetal anatomy and no evidence of cardiac malformations. The remainder of her pregnancy was uncomplicated, and she gave birth vaginally at 41 weeks to a baby boy weighing 3700 g.

THE TAKEAWAY

There is a need to increase awareness of Lyme disease in pregnancy on a national level. It is the responsibility of every practitioner caring for obstetric patients in endemic regions to address new-onset rash promptly. There have been cases of women who experienced erythema migrans and arthralgias after exposure to a tick bite, later delivering infants with cardiac anomalies such as atrial and ventricular septal defects.¹⁰ In obstetric patients acutely infected during the first trimester, a fetal echocardiogram is reasonable, given the demonstrated high potential for fetal cardiac anomalies.

Preventing adverse fetal outcomes requires early treatment with antibiotics. The CDC maintains that there have been no life-threatening adverse fetal effects from Lyme disease seen in women who are appropriately treated, as well as no transmission of Lyme disease in the breast milk of lactating mothers.⁹

THE CASE

A 31-year-old woman presented to her obstetrician’s office at 16 weeks’ gestation with a 2-day history of low-grade fever and an erythematous rash measuring 1 x 4 cm on her right groin. She had a medical history of a penicillin allergy (urticaria) and her outdoor activities included gardening and picnicking.

We suspected that she was experiencing an allergic reaction and recommended an antihistamine (diphenhydramine). The patient returned 4 days later with new symptoms including headache, photophobia, neck pain, unilateral large joint pain, and periorbital cellulitis, as well as expansion of her rash. She was afebrile and an examination revealed that the 1 x 4 cm rash on her groin had grown; it was now a demarcated erythematous rash with faint central clearing measuring 5 x 8 cm. Right periorbital erythema and nuchal rigidity were also noted.

Because of her expanding rash and nuchal rigidity, we suspected Lyme meningitis and we referred her to the emergency department. Within 24 hours, the rash had spread to her abdomen, thigh, and wrist, and was consistent with erythema migrans.

Laboratory evaluation revealed an increased number of white bloods cells (13.5 million cells/mcL; normal range 4.5-11.0 million cells/mcL), and an increased number of neutrophils (10.8 million cells/mcL; normal range 1.8-8 million cells/mcL), indicating leukocytosis with a left shift. Lab tests also revealed a low hemoglobin level (10.6 g/dL; normal range 12-16 g/dL) and a mean corpuscular volume of 85.6 fL/red cell (normal range 80-100 fL/red cell), indicating microcytic anemia. A lumbar puncture was negative for disseminated Lyme disease by Gram stain, culture, and polymerase chain reaction.

THE DIAGNOSIS

A diagnosis of Lyme disease was confirmed with a positive Lyme titer serology via an enzyme-linked immunosorbent assay. The rash and other symptoms responded promptly to intravenous ceftriaxone 2 g, and the patient was discharged home on oral cefuroxime 500 mg bid for 14 days.

DISCUSSION

Lyme disease is the most common vector-borne illness in the United States, concentrated heavily in the Northeast and upper Midwest.¹ The most recent information released by the Centers for Disease Control and Prevention (CDC) lists Vermont, Maine, Pennsylvania, Rhode Island, Connecticut, New Jersey, Massachusetts, Delaware, New Hampshire, and Minnesota as the states with the highest incidence of Lyme disease.²

The number of reported cases in the United States has increased over the past 2 decades, from approximately 11,000 in 1995 to about 28,000 in 2015.³ Over the past year, we have seen several cases of Lyme disease in the obstetric population of our own practice.

Prompt treatment is crucial. Pregnant women who are acutely infected with Borrelia burgdorferi (the primary cause of Lyme disease) and do not receive treatment have experienced multiple adverse pregnancy outcomes, including preterm delivery, infants born with rash, and stillbirth.⁴ Additional concern exists for fetal cardiac anomalies, with data showing that there are twice as many cardiac defects in children born to mothers residing in endemic regions.⁵

What animal studies have taught us about Lyme disease

The potential causal relationship between Lyme disease and fetal demise was first studied in 2007. This case report involved the stillbirth of a full-term baby from an acutely infected woman who did not receive treatment. She experienced erythema multiforme 6 weeks prior to delivery.⁶

A fetal echocardiogram is reasonable in pregnant women acutely infected with Lyme disease during the first trimester, given the high potential for fetal cardiac anomalies.

The vast majority of research on Lyme disease in pregnancy comes from work with mice and dogs. These studies confirmed that acute infection with Lyme disease is associated with an increased risk of adverse fetal outcomes, specifically fetal death.⁷

Silver et al further researched the association using murine models in the 1980s. They found that fetal death occurred in 12% of acutely infected mice, compared with none of the mice that were chronically infected.⁷

In 2010, Lakos and Solymosi examined the effects of Lyme disease on pregnancy outcomes in acutely infected women. Seven out of 95 pregnant women acutely infected with B burgdorferi experienced fetal demise, further supporting the association seen in animal experiments.⁸

Treating pregnant patients

Doxycycline and tetracycline, which are routinely used to treat Lyme disease, are not appropriate in the obstetric population. The CDC recommends up to a 3-week course of antibiotics; the standard regimen is amoxicillin 500 mg by mouth tid. For women who are allergic to penicillin, as was the case with our patient, cefuroxime 500 mg by mouth bid is the treatment of choice.⁹

Our patient underwent a detailed ultrasound at 21 weeks, which revealed normal fetal anatomy and no evidence of cardiac malformations. The remainder of her pregnancy was uncomplicated, and she gave birth vaginally at 41 weeks to a baby boy weighing 3700 g.

THE TAKEAWAY

There is a need to increase awareness of Lyme disease in pregnancy on a national level. It is the responsibility of every practitioner caring for obstetric patients in endemic regions to address new-onset rash promptly. There have been cases of women who experienced erythema migrans and arthralgias after exposure to a tick bite, later delivering infants with cardiac anomalies such as atrial and ventricular septal defects.¹⁰ In obstetric patients acutely infected during the first trimester, a fetal echocardiogram is reasonable, given the demonstrated high potential for fetal cardiac anomalies.

Preventing adverse fetal outcomes requires early treatment with antibiotics. The CDC maintains that there have been no life-threatening adverse fetal effects from Lyme disease seen in women who are appropriately treated, as well as no transmission of Lyme disease in the breast milk of lactating mothers.⁹

A 66-year-old white woman presented to her primary care clinic with concerns about hair loss, which began 2 years ago. Recently, she had noticed some “bumps” on her cheeks, as well.

On physical examination, the physician noted hair loss in a symmetric 2-cm band-like distribution across her frontal and temporal scalp (FIGURES 1 and 2). In both areas, there was moderate perifollicular erythema, scale, and what appeared to be scarring.

The patient had lost most of her eyebrow hairs, and had prominent temporal veins (FIGURE 2) and flesh-colored papules on her cheeks. She had no significant medical history, was emotionally stable, and recently had a satisfactory health care maintenance exam. The postmenopausal patient’s last menses was 15 years earlier, and she was not taking hormone replacement.

WHAT IS YOUR DIAGNOSIS?
HOW WOULD YOU TREAT THIS PATIENT?

Diagnosis: Frontal fibrosing alopecia

The patient was referred to our dermatology clinic, which specializes in hair loss. Based on the clinical findings, we suspected that this was a case of frontal fibrosing alopecia (FFA), a primary lymphocytic cicatricial (scarring) alopecia. A dermatopathologist confirmed the diagnosis via histologic review.

A condition on the rise. The incidence of FFA has been steadily increasing internationally since the condition was first described in 1994.¹ Among patients referred to a specialty clinic for hair loss, diagnosis of FFA has increased from 1.6% in 2000 to 17% in 2011.²

FFA is characterized by symmetric band-like hair loss with evidence of scarring in the frontal and temporal regions of the scalp. (The extent of hair loss can be assessed by retracting the patient’s hair and having the patient raise his or her eyebrows and wrinkle the forehead in a surprised look.) FFA is accompanied by eyebrow loss in 73% to 95% of patients.^2,3 Mild to severe perifollicular (and possibly more generalized) erythema and scale are usually present. In addition, erythematous or skin-colored papules may appear on the face,³ and marked exaggeration of the temporal veins is a common finding.

More than 80% of patients with frontal fibrosing alopecia are postmenopausal women.

Most patients with FFA (83%) are postmenopausal women and nearly all (98.6%) have Fitzpatrick skin type 1 or 2 (white skin that burns easily and doesn’t readily tan).⁴ Other pertinent findings include the absence of oral lesions, nail changes, or other skin diseases.

A subtype of another condition? Because they are similar histologically, some consider FFA to be a subtype of lichen planopilaris. (See “Scarring alopecia in a woman with psoriasis,” J Fam Pract. 2015;64:E1-E3.)

A punch biopsy to confirm the diagnosis of FFA should be taken from the leading edge of the hair loss and, ideally, reviewed by a dermatopathologist. Histologic examination will reveal a lichenoid lymphocytic infiltrate (predominantly around the hair follicle where the follicular stem cells reside), resulting in fibrosis and scarring.⁵

Rule out other causes of hair loss

In addition to confirming the diagnosis with histologic examination, you’ll also need to have ruled out the following conditions in the differential.

Alopecia areata may mimic the ophiasis (band-like) pattern of hair loss seen with FFA, but it is a non-scarring disorder that typically lacks any signs of inflammation.

Female pattern hair loss is characterized by a decrease in hair density and thinning. The condition is non-scarring and usually involves the frontal and vertex (crown) regions of the scalp.

Discoid lupus erythematosus is characterized by circular scarring hair loss with a central patch of inflammation, as well as depigmentation.

Central centrifugal cicatricial alopecia predominantly affects black women and is characterized by circular hair loss of the vertex, with perifollicular inflammation and scarring.

Traction alopecia can occur in the same location as FFA, but is not usually associated with perifollicular inflammation. This condition can cause scarring if traction has been longstanding and persistent. There is usually a history of certain hairstyles (such as braiding) associated with chronic tension on hair fibers.

Numerous Tx strategies exist, but they are not well studied

Because there are no published randomized clinical trials on treatment for FFA, few evidence-based treatment strategies exist.⁶ In addition, the prognosis is variable. Experts have employed numerous treatment strategies, including topical and intralesional steroids, immunosuppressive medications, antibiotics, and anti-androgen therapy, with varying results.^4,6 For most primary care physicians, it’s best to refer patients to a dermatologist to initiate treatment.

Intralesional steroids such as triamcinolone acetonide (5-10 mg/cc), as well as high-potency topical steroids, are generally helpful to stabilize the disease. There is also some evidence of benefit from oral dutasteride or finasteride at variable doses.⁶ Immunosuppressants such as hydroxychloroquine may also be used as second-line treatments, although the benefit-to-risk ratio needs to be taken into consideration.⁷

Early detection is key. In general, treatment should be initiated as soon as possible to prevent disease progression and reduce permanent scarring and hair loss. The Lichen Planopilaris Activity Index⁷ is a tool that clinicians can use to measure disease severity and track changes in disease activity through patient report of symptoms and measurements of scalp inflammation.

Our patient was started on a regimen of topical high-potency steroids (clobetasol foam, 0.05%), with targeted, intralesional injection of steroids (10 mg/cc of triamcinolone acetonide) to areas with the most inflammation. The patient was advised to use ketoconazole 2% shampoo while showering.

These interventions decreased our patient’s symptoms dramatically. Her scalp erythema and scale improved, but the hair did not regrow. One year later, her hairline was clinically stable with no evidence of disease progression. She continues to see a dermatologist annually.

CORRESPONDENCE
David V. Power, MB, MPH, Department of Family Medicine and Community Health, University of Minnesota, 516 Delaware St. SE, Minneapolis, MN 55455; [email protected].

A 66-year-old white woman presented to her primary care clinic with concerns about hair loss, which began 2 years ago. Recently, she had noticed some “bumps” on her cheeks, as well.

On physical examination, the physician noted hair loss in a symmetric 2-cm band-like distribution across her frontal and temporal scalp (FIGURES 1 and 2). In both areas, there was moderate perifollicular erythema, scale, and what appeared to be scarring.

The patient had lost most of her eyebrow hairs, and had prominent temporal veins (FIGURE 2) and flesh-colored papules on her cheeks. She had no significant medical history, was emotionally stable, and recently had a satisfactory health care maintenance exam. The postmenopausal patient’s last menses was 15 years earlier, and she was not taking hormone replacement.

WHAT IS YOUR DIAGNOSIS?
HOW WOULD YOU TREAT THIS PATIENT?

Diagnosis: Frontal fibrosing alopecia

The patient was referred to our dermatology clinic, which specializes in hair loss. Based on the clinical findings, we suspected that this was a case of frontal fibrosing alopecia (FFA), a primary lymphocytic cicatricial (scarring) alopecia. A dermatopathologist confirmed the diagnosis via histologic review.

A condition on the rise. The incidence of FFA has been steadily increasing internationally since the condition was first described in 1994.¹ Among patients referred to a specialty clinic for hair loss, diagnosis of FFA has increased from 1.6% in 2000 to 17% in 2011.²

FFA is characterized by symmetric band-like hair loss with evidence of scarring in the frontal and temporal regions of the scalp. (The extent of hair loss can be assessed by retracting the patient’s hair and having the patient raise his or her eyebrows and wrinkle the forehead in a surprised look.) FFA is accompanied by eyebrow loss in 73% to 95% of patients.^2,3 Mild to severe perifollicular (and possibly more generalized) erythema and scale are usually present. In addition, erythematous or skin-colored papules may appear on the face,³ and marked exaggeration of the temporal veins is a common finding.

More than 80% of patients with frontal fibrosing alopecia are postmenopausal women.

Most patients with FFA (83%) are postmenopausal women and nearly all (98.6%) have Fitzpatrick skin type 1 or 2 (white skin that burns easily and doesn’t readily tan).⁴ Other pertinent findings include the absence of oral lesions, nail changes, or other skin diseases.

A subtype of another condition? Because they are similar histologically, some consider FFA to be a subtype of lichen planopilaris. (See “Scarring alopecia in a woman with psoriasis,” J Fam Pract. 2015;64:E1-E3.)

A punch biopsy to confirm the diagnosis of FFA should be taken from the leading edge of the hair loss and, ideally, reviewed by a dermatopathologist. Histologic examination will reveal a lichenoid lymphocytic infiltrate (predominantly around the hair follicle where the follicular stem cells reside), resulting in fibrosis and scarring.⁵

Rule out other causes of hair loss

In addition to confirming the diagnosis with histologic examination, you’ll also need to have ruled out the following conditions in the differential.

Alopecia areata may mimic the ophiasis (band-like) pattern of hair loss seen with FFA, but it is a non-scarring disorder that typically lacks any signs of inflammation.

Female pattern hair loss is characterized by a decrease in hair density and thinning. The condition is non-scarring and usually involves the frontal and vertex (crown) regions of the scalp.

Discoid lupus erythematosus is characterized by circular scarring hair loss with a central patch of inflammation, as well as depigmentation.

Central centrifugal cicatricial alopecia predominantly affects black women and is characterized by circular hair loss of the vertex, with perifollicular inflammation and scarring.

Traction alopecia can occur in the same location as FFA, but is not usually associated with perifollicular inflammation. This condition can cause scarring if traction has been longstanding and persistent. There is usually a history of certain hairstyles (such as braiding) associated with chronic tension on hair fibers.

Numerous Tx strategies exist, but they are not well studied

Because there are no published randomized clinical trials on treatment for FFA, few evidence-based treatment strategies exist.⁶ In addition, the prognosis is variable. Experts have employed numerous treatment strategies, including topical and intralesional steroids, immunosuppressive medications, antibiotics, and anti-androgen therapy, with varying results.^4,6 For most primary care physicians, it’s best to refer patients to a dermatologist to initiate treatment.

Intralesional steroids such as triamcinolone acetonide (5-10 mg/cc), as well as high-potency topical steroids, are generally helpful to stabilize the disease. There is also some evidence of benefit from oral dutasteride or finasteride at variable doses.⁶ Immunosuppressants such as hydroxychloroquine may also be used as second-line treatments, although the benefit-to-risk ratio needs to be taken into consideration.⁷

Early detection is key. In general, treatment should be initiated as soon as possible to prevent disease progression and reduce permanent scarring and hair loss. The Lichen Planopilaris Activity Index⁷ is a tool that clinicians can use to measure disease severity and track changes in disease activity through patient report of symptoms and measurements of scalp inflammation.

Our patient was started on a regimen of topical high-potency steroids (clobetasol foam, 0.05%), with targeted, intralesional injection of steroids (10 mg/cc of triamcinolone acetonide) to areas with the most inflammation. The patient was advised to use ketoconazole 2% shampoo while showering.

These interventions decreased our patient’s symptoms dramatically. Her scalp erythema and scale improved, but the hair did not regrow. One year later, her hairline was clinically stable with no evidence of disease progression. She continues to see a dermatologist annually.

CORRESPONDENCE
David V. Power, MB, MPH, Department of Family Medicine and Community Health, University of Minnesota, 516 Delaware St. SE, Minneapolis, MN 55455; [email protected].

A 66-year-old white woman presented to her primary care clinic with concerns about hair loss, which began 2 years ago. Recently, she had noticed some “bumps” on her cheeks, as well.

On physical examination, the physician noted hair loss in a symmetric 2-cm band-like distribution across her frontal and temporal scalp (FIGURES 1 and 2). In both areas, there was moderate perifollicular erythema, scale, and what appeared to be scarring.

The patient had lost most of her eyebrow hairs, and had prominent temporal veins (FIGURE 2) and flesh-colored papules on her cheeks. She had no significant medical history, was emotionally stable, and recently had a satisfactory health care maintenance exam. The postmenopausal patient’s last menses was 15 years earlier, and she was not taking hormone replacement.

WHAT IS YOUR DIAGNOSIS?
HOW WOULD YOU TREAT THIS PATIENT?

Diagnosis: Frontal fibrosing alopecia

The patient was referred to our dermatology clinic, which specializes in hair loss. Based on the clinical findings, we suspected that this was a case of frontal fibrosing alopecia (FFA), a primary lymphocytic cicatricial (scarring) alopecia. A dermatopathologist confirmed the diagnosis via histologic review.

A condition on the rise. The incidence of FFA has been steadily increasing internationally since the condition was first described in 1994.¹ Among patients referred to a specialty clinic for hair loss, diagnosis of FFA has increased from 1.6% in 2000 to 17% in 2011.²

FFA is characterized by symmetric band-like hair loss with evidence of scarring in the frontal and temporal regions of the scalp. (The extent of hair loss can be assessed by retracting the patient’s hair and having the patient raise his or her eyebrows and wrinkle the forehead in a surprised look.) FFA is accompanied by eyebrow loss in 73% to 95% of patients.^2,3 Mild to severe perifollicular (and possibly more generalized) erythema and scale are usually present. In addition, erythematous or skin-colored papules may appear on the face,³ and marked exaggeration of the temporal veins is a common finding.

More than 80% of patients with frontal fibrosing alopecia are postmenopausal women.

Most patients with FFA (83%) are postmenopausal women and nearly all (98.6%) have Fitzpatrick skin type 1 or 2 (white skin that burns easily and doesn’t readily tan).⁴ Other pertinent findings include the absence of oral lesions, nail changes, or other skin diseases.

A subtype of another condition? Because they are similar histologically, some consider FFA to be a subtype of lichen planopilaris. (See “Scarring alopecia in a woman with psoriasis,” J Fam Pract. 2015;64:E1-E3.)

A punch biopsy to confirm the diagnosis of FFA should be taken from the leading edge of the hair loss and, ideally, reviewed by a dermatopathologist. Histologic examination will reveal a lichenoid lymphocytic infiltrate (predominantly around the hair follicle where the follicular stem cells reside), resulting in fibrosis and scarring.⁵

Rule out other causes of hair loss

In addition to confirming the diagnosis with histologic examination, you’ll also need to have ruled out the following conditions in the differential.

Alopecia areata may mimic the ophiasis (band-like) pattern of hair loss seen with FFA, but it is a non-scarring disorder that typically lacks any signs of inflammation.

Female pattern hair loss is characterized by a decrease in hair density and thinning. The condition is non-scarring and usually involves the frontal and vertex (crown) regions of the scalp.

Discoid lupus erythematosus is characterized by circular scarring hair loss with a central patch of inflammation, as well as depigmentation.

Central centrifugal cicatricial alopecia predominantly affects black women and is characterized by circular hair loss of the vertex, with perifollicular inflammation and scarring.

Traction alopecia can occur in the same location as FFA, but is not usually associated with perifollicular inflammation. This condition can cause scarring if traction has been longstanding and persistent. There is usually a history of certain hairstyles (such as braiding) associated with chronic tension on hair fibers.

Numerous Tx strategies exist, but they are not well studied

Because there are no published randomized clinical trials on treatment for FFA, few evidence-based treatment strategies exist.⁶ In addition, the prognosis is variable. Experts have employed numerous treatment strategies, including topical and intralesional steroids, immunosuppressive medications, antibiotics, and anti-androgen therapy, with varying results.^4,6 For most primary care physicians, it’s best to refer patients to a dermatologist to initiate treatment.

Intralesional steroids such as triamcinolone acetonide (5-10 mg/cc), as well as high-potency topical steroids, are generally helpful to stabilize the disease. There is also some evidence of benefit from oral dutasteride or finasteride at variable doses.⁶ Immunosuppressants such as hydroxychloroquine may also be used as second-line treatments, although the benefit-to-risk ratio needs to be taken into consideration.⁷

Early detection is key. In general, treatment should be initiated as soon as possible to prevent disease progression and reduce permanent scarring and hair loss. The Lichen Planopilaris Activity Index⁷ is a tool that clinicians can use to measure disease severity and track changes in disease activity through patient report of symptoms and measurements of scalp inflammation.

Our patient was started on a regimen of topical high-potency steroids (clobetasol foam, 0.05%), with targeted, intralesional injection of steroids (10 mg/cc of triamcinolone acetonide) to areas with the most inflammation. The patient was advised to use ketoconazole 2% shampoo while showering.

These interventions decreased our patient’s symptoms dramatically. Her scalp erythema and scale improved, but the hair did not regrow. One year later, her hairline was clinically stable with no evidence of disease progression. She continues to see a dermatologist annually.

CORRESPONDENCE
David V. Power, MB, MPH, Department of Family Medicine and Community Health, University of Minnesota, 516 Delaware St. SE, Minneapolis, MN 55455; [email protected].

THE CASE

A 46-year-old man presented to the emergency department (ED) with sudden-onset right-sided visual loss. He had a history of asthma, but no family history of hypercoagulability, deep vein thrombosis (DVT), or stroke. The patient had an active lifestyle that included scuba diving, mountain biking, and hockey (coaching and playing). The physical examination revealed a right homonymous upper quadrantanopia. The neurologic examination was within normal limits, except for the visual deficit and unequal pupil size. A computerized tomography scan of the patient’s head did not reveal any lesions.

Based on the patient’s clinical picture, the ED physician prescribed alteplase, a tissue plasminogen activator (tPA), and admitted him to the intensive care unit for monitoring.

Subsequent magnetic resonance imaging (MRI) of the brain showed multiple small areas of acute infarct in the posterior circulation territory bilaterally, with involvement of small portions of the bilateral cerebellar hemispheres and parts of the left occipital lobe (FIGURE 1A and 1B).

An electrocardiogram showed no evidence of atrial fibrillation, and hypercoagulability studies were within normal limits. There was no evidence of May-Thurner anatomy, and an ultrasound of the lower extremities showed no DVT.

THE DIAGNOSIS

An echocardiogram with bubble study confirmed a diagnosis of patent foramen ovale (PFO) with bidirectional flow, a normal ejection fraction, and no evidence of left ventricular or left atrial thrombus. We started the patient on the anticoagulant enoxaparin 70 mg bid bridged with warfarin 5 mg/d.

This case illustrates the importance of lifestyle and occupation when evaluating patients with cryptogenic stroke associated with patent foramen ovale.

Taking the patient’s active lifestyle into consideration, he was approved for PFO closure by the PFO committee and underwent closure. Following treatment, the patient was left with a residual 2-mm blind spot in the right visual field. At a 2-year follow-up visit, he showed no new focal deficits or recurrent symptoms.

DISCUSSION

Since 1988 when Lechat et al reported increased incidence of PFO in young stroke patients,¹ many studies have supported the association between PFO and cryptogenic stroke (CS) in young adults.² Because it remained controversial as to whether PFO is a risk factor for stroke or transient ischemic attack recurrence,³ researchers investigated PFO closure as a preventive measure to decrease stroke recurrence in patients with both CS and PFO.

A 2012 meta-analysis showed possible benefits of closure compared with medical management using antiplatelet or anticoagulation therapies.⁴ However, these results were not supported by results of other studies. These include the CLOSURE I trial,⁵ which compared device closure of PFO with medical therapy, and the RESPECT⁶ and PC trials,⁷ which did not show a significant difference in the primary end point of recurrent stroke between patients who received medical therapy and those who had PFO closure.

American Heart Association/American Stroke Association’s 2011 guidelines recommend only antiplatelet therapy for patients with CS and PFO.⁸ While there is consensus that surgical closure is not better than a medical approach to patients with CS and PFO, cases should be individualized, as a patient’s clinical or social factors may dictate otherwise.

Lifestyle may warrant PFO closure

No previous studies have considered occupation or hobbies as an indication for PFO closure in patients with CS. Our patient’s active lifestyle, particularly his scuba diving and participation in contact sports, made him a poor candidate for anticoagulation. Scuba diving is associated with decompression sickness and air emboli, which can be a mechanism of cerebral ischemia, especially in patients with a right-to-left shunt, such as with PFO.⁹

We did not observe a strong temporal relationship between diving and stroke in our patient. MRI findings suggested that he had multiple minor embolic events over time, which is consistent with a prior case report.⁹ This suggested air emboli as a possible source of stroke, in which case, our patient might not benefit from antiplatelet or anticoagulation therapy.

THE TAKEAWAY

This case illustrates the importance of a thorough social history and knowledge of the patient’s hobbies, occupation, and preferences in evaluating and treating individuals with CS associated with PFO. The current literature does not provide complete answers to the cause, diagnosis, and management of CS; additional research is needed.

The work-up involved in defining the etiology of stroke includes, but is not limited to, head and brain imaging, an echocardiogram, hypercoagulability tests, and vascular imaging. The work of Sanna et al showed that approximately 12% of patients with CS have atrial fibrillation when monitored over a one-year period, suggesting atrial fibrillation as a possible cause in some cases.¹⁰

As the case described here demonstrates, further research is warranted regarding how a patient’s occupation and lifestyle factor into decision-making for patients with PFO.

THE CASE

A 46-year-old man presented to the emergency department (ED) with sudden-onset right-sided visual loss. He had a history of asthma, but no family history of hypercoagulability, deep vein thrombosis (DVT), or stroke. The patient had an active lifestyle that included scuba diving, mountain biking, and hockey (coaching and playing). The physical examination revealed a right homonymous upper quadrantanopia. The neurologic examination was within normal limits, except for the visual deficit and unequal pupil size. A computerized tomography scan of the patient’s head did not reveal any lesions.

Based on the patient’s clinical picture, the ED physician prescribed alteplase, a tissue plasminogen activator (tPA), and admitted him to the intensive care unit for monitoring.

Subsequent magnetic resonance imaging (MRI) of the brain showed multiple small areas of acute infarct in the posterior circulation territory bilaterally, with involvement of small portions of the bilateral cerebellar hemispheres and parts of the left occipital lobe (FIGURE 1A and 1B).

An electrocardiogram showed no evidence of atrial fibrillation, and hypercoagulability studies were within normal limits. There was no evidence of May-Thurner anatomy, and an ultrasound of the lower extremities showed no DVT.

THE DIAGNOSIS

An echocardiogram with bubble study confirmed a diagnosis of patent foramen ovale (PFO) with bidirectional flow, a normal ejection fraction, and no evidence of left ventricular or left atrial thrombus. We started the patient on the anticoagulant enoxaparin 70 mg bid bridged with warfarin 5 mg/d.

This case illustrates the importance of lifestyle and occupation when evaluating patients with cryptogenic stroke associated with patent foramen ovale.

Taking the patient’s active lifestyle into consideration, he was approved for PFO closure by the PFO committee and underwent closure. Following treatment, the patient was left with a residual 2-mm blind spot in the right visual field. At a 2-year follow-up visit, he showed no new focal deficits or recurrent symptoms.

DISCUSSION

Since 1988 when Lechat et al reported increased incidence of PFO in young stroke patients,¹ many studies have supported the association between PFO and cryptogenic stroke (CS) in young adults.² Because it remained controversial as to whether PFO is a risk factor for stroke or transient ischemic attack recurrence,³ researchers investigated PFO closure as a preventive measure to decrease stroke recurrence in patients with both CS and PFO.

A 2012 meta-analysis showed possible benefits of closure compared with medical management using antiplatelet or anticoagulation therapies.⁴ However, these results were not supported by results of other studies. These include the CLOSURE I trial,⁵ which compared device closure of PFO with medical therapy, and the RESPECT⁶ and PC trials,⁷ which did not show a significant difference in the primary end point of recurrent stroke between patients who received medical therapy and those who had PFO closure.

American Heart Association/American Stroke Association’s 2011 guidelines recommend only antiplatelet therapy for patients with CS and PFO.⁸ While there is consensus that surgical closure is not better than a medical approach to patients with CS and PFO, cases should be individualized, as a patient’s clinical or social factors may dictate otherwise.

Lifestyle may warrant PFO closure

No previous studies have considered occupation or hobbies as an indication for PFO closure in patients with CS. Our patient’s active lifestyle, particularly his scuba diving and participation in contact sports, made him a poor candidate for anticoagulation. Scuba diving is associated with decompression sickness and air emboli, which can be a mechanism of cerebral ischemia, especially in patients with a right-to-left shunt, such as with PFO.⁹

We did not observe a strong temporal relationship between diving and stroke in our patient. MRI findings suggested that he had multiple minor embolic events over time, which is consistent with a prior case report.⁹ This suggested air emboli as a possible source of stroke, in which case, our patient might not benefit from antiplatelet or anticoagulation therapy.

THE TAKEAWAY

This case illustrates the importance of a thorough social history and knowledge of the patient’s hobbies, occupation, and preferences in evaluating and treating individuals with CS associated with PFO. The current literature does not provide complete answers to the cause, diagnosis, and management of CS; additional research is needed.

The work-up involved in defining the etiology of stroke includes, but is not limited to, head and brain imaging, an echocardiogram, hypercoagulability tests, and vascular imaging. The work of Sanna et al showed that approximately 12% of patients with CS have atrial fibrillation when monitored over a one-year period, suggesting atrial fibrillation as a possible cause in some cases.¹⁰

As the case described here demonstrates, further research is warranted regarding how a patient’s occupation and lifestyle factor into decision-making for patients with PFO.

THE CASE

A 46-year-old man presented to the emergency department (ED) with sudden-onset right-sided visual loss. He had a history of asthma, but no family history of hypercoagulability, deep vein thrombosis (DVT), or stroke. The patient had an active lifestyle that included scuba diving, mountain biking, and hockey (coaching and playing). The physical examination revealed a right homonymous upper quadrantanopia. The neurologic examination was within normal limits, except for the visual deficit and unequal pupil size. A computerized tomography scan of the patient’s head did not reveal any lesions.

Based on the patient’s clinical picture, the ED physician prescribed alteplase, a tissue plasminogen activator (tPA), and admitted him to the intensive care unit for monitoring.

Subsequent magnetic resonance imaging (MRI) of the brain showed multiple small areas of acute infarct in the posterior circulation territory bilaterally, with involvement of small portions of the bilateral cerebellar hemispheres and parts of the left occipital lobe (FIGURE 1A and 1B).

An electrocardiogram showed no evidence of atrial fibrillation, and hypercoagulability studies were within normal limits. There was no evidence of May-Thurner anatomy, and an ultrasound of the lower extremities showed no DVT.

THE DIAGNOSIS

An echocardiogram with bubble study confirmed a diagnosis of patent foramen ovale (PFO) with bidirectional flow, a normal ejection fraction, and no evidence of left ventricular or left atrial thrombus. We started the patient on the anticoagulant enoxaparin 70 mg bid bridged with warfarin 5 mg/d.

This case illustrates the importance of lifestyle and occupation when evaluating patients with cryptogenic stroke associated with patent foramen ovale.

Taking the patient’s active lifestyle into consideration, he was approved for PFO closure by the PFO committee and underwent closure. Following treatment, the patient was left with a residual 2-mm blind spot in the right visual field. At a 2-year follow-up visit, he showed no new focal deficits or recurrent symptoms.

DISCUSSION

Since 1988 when Lechat et al reported increased incidence of PFO in young stroke patients,¹ many studies have supported the association between PFO and cryptogenic stroke (CS) in young adults.² Because it remained controversial as to whether PFO is a risk factor for stroke or transient ischemic attack recurrence,³ researchers investigated PFO closure as a preventive measure to decrease stroke recurrence in patients with both CS and PFO.

A 2012 meta-analysis showed possible benefits of closure compared with medical management using antiplatelet or anticoagulation therapies.⁴ However, these results were not supported by results of other studies. These include the CLOSURE I trial,⁵ which compared device closure of PFO with medical therapy, and the RESPECT⁶ and PC trials,⁷ which did not show a significant difference in the primary end point of recurrent stroke between patients who received medical therapy and those who had PFO closure.

American Heart Association/American Stroke Association’s 2011 guidelines recommend only antiplatelet therapy for patients with CS and PFO.⁸ While there is consensus that surgical closure is not better than a medical approach to patients with CS and PFO, cases should be individualized, as a patient’s clinical or social factors may dictate otherwise.

Lifestyle may warrant PFO closure

No previous studies have considered occupation or hobbies as an indication for PFO closure in patients with CS. Our patient’s active lifestyle, particularly his scuba diving and participation in contact sports, made him a poor candidate for anticoagulation. Scuba diving is associated with decompression sickness and air emboli, which can be a mechanism of cerebral ischemia, especially in patients with a right-to-left shunt, such as with PFO.⁹

We did not observe a strong temporal relationship between diving and stroke in our patient. MRI findings suggested that he had multiple minor embolic events over time, which is consistent with a prior case report.⁹ This suggested air emboli as a possible source of stroke, in which case, our patient might not benefit from antiplatelet or anticoagulation therapy.

THE TAKEAWAY

This case illustrates the importance of a thorough social history and knowledge of the patient’s hobbies, occupation, and preferences in evaluating and treating individuals with CS associated with PFO. The current literature does not provide complete answers to the cause, diagnosis, and management of CS; additional research is needed.

The work-up involved in defining the etiology of stroke includes, but is not limited to, head and brain imaging, an echocardiogram, hypercoagulability tests, and vascular imaging. The work of Sanna et al showed that approximately 12% of patients with CS have atrial fibrillation when monitored over a one-year period, suggesting atrial fibrillation as a possible cause in some cases.¹⁰

As the case described here demonstrates, further research is warranted regarding how a patient’s occupation and lifestyle factor into decision-making for patients with PFO.