Hematopoietic stem cells

in the bone marrow

New research indicates that cycles of prolonged fasting may prevent chemotherapy-induced immunosuppressive toxicity and induce regeneration of the hematopoietic system.

Long periods of fasting reduced damage in bone marrow stem and progenitor cells and protected both mice and humans from chemotoxicity.

In mice, the fasting cycles “flipped a regenerative switch,” changing the signaling pathways for hematopoietic stem cells (HSCs).

Researchers reported these results in Cell Stem Cell.

“We could not predict that prolonged fasting would have such a remarkable effect in promoting stem cell-based regeneration of the hematopoietic system,” said study author Valter Longo, PhD, of the University of Southern California in Los Angeles.

“When you starve, the system tries to save energy, and one of the things it can do to save energy is to recycle a lot of the immune cells that are not needed, especially those that may be damaged. What we started noticing in both our human work and animal work is that the white blood cell count goes down with prolonged fasting. Then, when you re-feed, the blood cells come back. So we started thinking, well, where does it come from?”

The researchers found that prolonged fasting reduced the enzyme PKA, which regulates HSC self-renewal and pluripotency.

“PKA is the key gene that needs to shut down in order for these stem cells to switch into regenerative mode,” Dr Longo said. “It gives the ‘okay’ for stem cells to go ahead and begin proliferating and rebuild the entire system.”

Prolonged fasting also lowered levels of IGF-1, a growth-factor hormone that has been linked to aging, tumor progression, and cancer risk.

In addition to downregulating the IGF-1/PKA pathway in HSCs, prolonged fasting protected hematopoietic cells from chemotoxicity and promoted HSC self-renewal to reverse immunosuppression.

Experiments revealed that inhibiting IGF-1 or PKA signaling mimicked the effects of prolonged fasting.

The researchers also analyzed a small group of patients from a pilot study evaluating the effects of fasting before chemotherapy. Fasting for 72 hours, but not 24 hours, ensured that patients had normal lymphocyte counts and maintained a normal lineage balance in white blood cells after chemotherapy.

Dr Longo’s lab is now conducting further research on controlled dietary interventions and stem cell regeneration in both animal and clinical studies.

Hematopoietic stem cells

in the bone marrow

New research indicates that cycles of prolonged fasting may prevent chemotherapy-induced immunosuppressive toxicity and induce regeneration of the hematopoietic system.

Long periods of fasting reduced damage in bone marrow stem and progenitor cells and protected both mice and humans from chemotoxicity.

In mice, the fasting cycles “flipped a regenerative switch,” changing the signaling pathways for hematopoietic stem cells (HSCs).

Researchers reported these results in Cell Stem Cell.

“We could not predict that prolonged fasting would have such a remarkable effect in promoting stem cell-based regeneration of the hematopoietic system,” said study author Valter Longo, PhD, of the University of Southern California in Los Angeles.

“When you starve, the system tries to save energy, and one of the things it can do to save energy is to recycle a lot of the immune cells that are not needed, especially those that may be damaged. What we started noticing in both our human work and animal work is that the white blood cell count goes down with prolonged fasting. Then, when you re-feed, the blood cells come back. So we started thinking, well, where does it come from?”

The researchers found that prolonged fasting reduced the enzyme PKA, which regulates HSC self-renewal and pluripotency.

“PKA is the key gene that needs to shut down in order for these stem cells to switch into regenerative mode,” Dr Longo said. “It gives the ‘okay’ for stem cells to go ahead and begin proliferating and rebuild the entire system.”

Prolonged fasting also lowered levels of IGF-1, a growth-factor hormone that has been linked to aging, tumor progression, and cancer risk.

In addition to downregulating the IGF-1/PKA pathway in HSCs, prolonged fasting protected hematopoietic cells from chemotoxicity and promoted HSC self-renewal to reverse immunosuppression.

Experiments revealed that inhibiting IGF-1 or PKA signaling mimicked the effects of prolonged fasting.

The researchers also analyzed a small group of patients from a pilot study evaluating the effects of fasting before chemotherapy. Fasting for 72 hours, but not 24 hours, ensured that patients had normal lymphocyte counts and maintained a normal lineage balance in white blood cells after chemotherapy.

Dr Longo’s lab is now conducting further research on controlled dietary interventions and stem cell regeneration in both animal and clinical studies.

Hematopoietic stem cells

in the bone marrow

New research indicates that cycles of prolonged fasting may prevent chemotherapy-induced immunosuppressive toxicity and induce regeneration of the hematopoietic system.

Long periods of fasting reduced damage in bone marrow stem and progenitor cells and protected both mice and humans from chemotoxicity.

In mice, the fasting cycles “flipped a regenerative switch,” changing the signaling pathways for hematopoietic stem cells (HSCs).

Researchers reported these results in Cell Stem Cell.

“We could not predict that prolonged fasting would have such a remarkable effect in promoting stem cell-based regeneration of the hematopoietic system,” said study author Valter Longo, PhD, of the University of Southern California in Los Angeles.

“When you starve, the system tries to save energy, and one of the things it can do to save energy is to recycle a lot of the immune cells that are not needed, especially those that may be damaged. What we started noticing in both our human work and animal work is that the white blood cell count goes down with prolonged fasting. Then, when you re-feed, the blood cells come back. So we started thinking, well, where does it come from?”

The researchers found that prolonged fasting reduced the enzyme PKA, which regulates HSC self-renewal and pluripotency.

“PKA is the key gene that needs to shut down in order for these stem cells to switch into regenerative mode,” Dr Longo said. “It gives the ‘okay’ for stem cells to go ahead and begin proliferating and rebuild the entire system.”

Prolonged fasting also lowered levels of IGF-1, a growth-factor hormone that has been linked to aging, tumor progression, and cancer risk.

In addition to downregulating the IGF-1/PKA pathway in HSCs, prolonged fasting protected hematopoietic cells from chemotoxicity and promoted HSC self-renewal to reverse immunosuppression.

Experiments revealed that inhibiting IGF-1 or PKA signaling mimicked the effects of prolonged fasting.

The researchers also analyzed a small group of patients from a pilot study evaluating the effects of fasting before chemotherapy. Fasting for 72 hours, but not 24 hours, ensured that patients had normal lymphocyte counts and maintained a normal lineage balance in white blood cells after chemotherapy.

Dr Longo’s lab is now conducting further research on controlled dietary interventions and stem cell regeneration in both animal and clinical studies.

Diffuse large B-cell lymphoma

The Israeli Ministry of Health has granted approval for the antineoplastic agent pixantrone (Pixuvri).

The drug is now approved as monotherapy for adults with relapsed or refractory aggressive B-cell non-Hodgkin lymphoma (NHL) who have received fewer than 4 previous courses of treatment.

The benefit of pixantrone has not been established when used as fifth-line or greater treatment in patients who were refractory to their last therapy.

Pixantrone will be distributed in Israel by the Neopharm Group.

“The approval of Pixuvri in Israel provides patients with aggressive B-cell NHL who have failed second- or third-line therapy a new approved option, where none existed before, that can effectively treat their disease with manageable side effects,” said Abraham Avigdor, MD, of Tel Aviv University.

“Patients who have relapsed after second-line therapy have a poor survival outcome. It is vital to have additional treatment options available, like Pixuvri, so we can provide these patients the best care possible and help them battle their disease.”

The main study of pixantrone, the phase 3 EXTEND PIX301 trial, compared the drug to other chemotherapeutic agents in patients with relapsed or refractory NHL. The response rate was 20% in the pixantrone arm and 6% in the comparator arm.

In addition, patients receiving pixantrone had longer progression-free survival than patients in the comparator group, with a median of 10.2 months and 7.6 months, respectively.

However, grade 3/4 adverse events—including neutropenia, leukopenia, and thrombocytopenia—were more common in the pixantrone arm.

Pixantrone is already marketed in the European Union. In 2012, the European Commission granted conditional marketing authorization for the drug as monotherapy for adults with relapsed or refractory aggressive B-cell NHL.

Under the provisions of the conditional marketing authorization, Cell Therapeutics, Inc., the company developing pixantrone, will be required to complete a post-marketing study aimed at confirming the drug’s clinical benefit.

The European Medicines Agency’s Committee for Medicinal Products for Human Use has accepted PIX306, a randomized, phase 3 trial comparing pixantrone plus rituximab to gemcitabine plus rituximab in patients who have relapsed after 1 to 3 prior regimens for aggressive B-cell NHL and who are not eligible for autologous stem cell transplant.

As a condition of approval, Cell Therapeutics has agreed to have the trial data available by June 2015.

Pixantrone is not approved for use in the US.

Diffuse large B-cell lymphoma

The Israeli Ministry of Health has granted approval for the antineoplastic agent pixantrone (Pixuvri).

The drug is now approved as monotherapy for adults with relapsed or refractory aggressive B-cell non-Hodgkin lymphoma (NHL) who have received fewer than 4 previous courses of treatment.

The benefit of pixantrone has not been established when used as fifth-line or greater treatment in patients who were refractory to their last therapy.

Pixantrone will be distributed in Israel by the Neopharm Group.

“The approval of Pixuvri in Israel provides patients with aggressive B-cell NHL who have failed second- or third-line therapy a new approved option, where none existed before, that can effectively treat their disease with manageable side effects,” said Abraham Avigdor, MD, of Tel Aviv University.

“Patients who have relapsed after second-line therapy have a poor survival outcome. It is vital to have additional treatment options available, like Pixuvri, so we can provide these patients the best care possible and help them battle their disease.”

The main study of pixantrone, the phase 3 EXTEND PIX301 trial, compared the drug to other chemotherapeutic agents in patients with relapsed or refractory NHL. The response rate was 20% in the pixantrone arm and 6% in the comparator arm.

In addition, patients receiving pixantrone had longer progression-free survival than patients in the comparator group, with a median of 10.2 months and 7.6 months, respectively.

However, grade 3/4 adverse events—including neutropenia, leukopenia, and thrombocytopenia—were more common in the pixantrone arm.

Pixantrone is already marketed in the European Union. In 2012, the European Commission granted conditional marketing authorization for the drug as monotherapy for adults with relapsed or refractory aggressive B-cell NHL.

Under the provisions of the conditional marketing authorization, Cell Therapeutics, Inc., the company developing pixantrone, will be required to complete a post-marketing study aimed at confirming the drug’s clinical benefit.

The European Medicines Agency’s Committee for Medicinal Products for Human Use has accepted PIX306, a randomized, phase 3 trial comparing pixantrone plus rituximab to gemcitabine plus rituximab in patients who have relapsed after 1 to 3 prior regimens for aggressive B-cell NHL and who are not eligible for autologous stem cell transplant.

As a condition of approval, Cell Therapeutics has agreed to have the trial data available by June 2015.

Pixantrone is not approved for use in the US.

Diffuse large B-cell lymphoma

The Israeli Ministry of Health has granted approval for the antineoplastic agent pixantrone (Pixuvri).

The drug is now approved as monotherapy for adults with relapsed or refractory aggressive B-cell non-Hodgkin lymphoma (NHL) who have received fewer than 4 previous courses of treatment.

The benefit of pixantrone has not been established when used as fifth-line or greater treatment in patients who were refractory to their last therapy.

Pixantrone will be distributed in Israel by the Neopharm Group.

“The approval of Pixuvri in Israel provides patients with aggressive B-cell NHL who have failed second- or third-line therapy a new approved option, where none existed before, that can effectively treat their disease with manageable side effects,” said Abraham Avigdor, MD, of Tel Aviv University.

“Patients who have relapsed after second-line therapy have a poor survival outcome. It is vital to have additional treatment options available, like Pixuvri, so we can provide these patients the best care possible and help them battle their disease.”

The main study of pixantrone, the phase 3 EXTEND PIX301 trial, compared the drug to other chemotherapeutic agents in patients with relapsed or refractory NHL. The response rate was 20% in the pixantrone arm and 6% in the comparator arm.

In addition, patients receiving pixantrone had longer progression-free survival than patients in the comparator group, with a median of 10.2 months and 7.6 months, respectively.

However, grade 3/4 adverse events—including neutropenia, leukopenia, and thrombocytopenia—were more common in the pixantrone arm.

Pixantrone is already marketed in the European Union. In 2012, the European Commission granted conditional marketing authorization for the drug as monotherapy for adults with relapsed or refractory aggressive B-cell NHL.

Under the provisions of the conditional marketing authorization, Cell Therapeutics, Inc., the company developing pixantrone, will be required to complete a post-marketing study aimed at confirming the drug’s clinical benefit.

The European Medicines Agency’s Committee for Medicinal Products for Human Use has accepted PIX306, a randomized, phase 3 trial comparing pixantrone plus rituximab to gemcitabine plus rituximab in patients who have relapsed after 1 to 3 prior regimens for aggressive B-cell NHL and who are not eligible for autologous stem cell transplant.

As a condition of approval, Cell Therapeutics has agreed to have the trial data available by June 2015.

Pixantrone is not approved for use in the US.

Malaria-infected cell bursting

Credit: Peter H. Seeberger

Researchers have used military technology to develop a test for detecting malaria parasites in the blood.

The team used a detector known as a focal plane array (FPA), which was originally developed for heat-seeking missiles.

The FPA gives highly detailed information on a sample area in minutes. The heat-seeking detector, which is coupled to an infrared imaging microscope, could detect the malaria parasite in a single red blood cell.

The infrared signature from the fatty acids of the parasites allowed the researchers to detect the parasite at its earliest stages and determine the number of parasites in a blood smear.

The team described the technology in Analyst.

“Our test detects malaria at its very early stages, so that doctors can stop the disease in its tracks before it takes hold and kills,” said study author Bayden Wood, PhD, of Monash University in Victoria, Australia. “We believe this sets the gold standard for malaria testing.”

“There are some excellent tests that diagnose malaria. However, the sensitivity is limited, and the best methods require hours of input from skilled microscopists, and that’s a problem in developing countries where malaria is most prevalent.”

The new test, on the other hand, gives an automatic diagnosis within 4 minutes and doesn’t require a specialist technician.

Study author Leann Tilley, PhD, of the University of Melbourne in Australia, said the test could make an impact in large-scale screening of malaria parasite carriers who do not present with the classic fever-type symptoms associated with the disease.

“In many countries, only people who display signs of malaria are treated,” Dr Tilley said. “But the problem with this approach is that some people don’t have typical flu-like symptoms associated with malaria, and this means a reservoir of parasites persists that can reemerge and spread very quickly within a community.”

“Our test works because it can detect the malaria parasite at the very early stages and can reliably detect it in an automated manner in a single red blood cell. No other test can do that.”

FPA detectors were originally developed for Javelin Portable anti-tank missiles in the 1990s. The heat-seeking detector is used on shoulder-fired missiles but can also be installed on tracked, wheeled, or amphibious vehicles, providing spatial and spectral information in a matter of seconds.

The FPA detector used in this project was coupled to a synchrotron source located at the InfraRed Environmental Imaging facility at the Synchrotron Radiation Center in Wisconsin.

For the next phase of this research, Dr Wood’s team is collaborating with Patcharee Jearanaikoon, PhD, of Kohn Kaen University in Thailand, to test the technology in clinics.

Malaria-infected cell bursting

Credit: Peter H. Seeberger

Researchers have used military technology to develop a test for detecting malaria parasites in the blood.

The team used a detector known as a focal plane array (FPA), which was originally developed for heat-seeking missiles.

The FPA gives highly detailed information on a sample area in minutes. The heat-seeking detector, which is coupled to an infrared imaging microscope, could detect the malaria parasite in a single red blood cell.

The infrared signature from the fatty acids of the parasites allowed the researchers to detect the parasite at its earliest stages and determine the number of parasites in a blood smear.

The team described the technology in Analyst.

“Our test detects malaria at its very early stages, so that doctors can stop the disease in its tracks before it takes hold and kills,” said study author Bayden Wood, PhD, of Monash University in Victoria, Australia. “We believe this sets the gold standard for malaria testing.”

“There are some excellent tests that diagnose malaria. However, the sensitivity is limited, and the best methods require hours of input from skilled microscopists, and that’s a problem in developing countries where malaria is most prevalent.”

The new test, on the other hand, gives an automatic diagnosis within 4 minutes and doesn’t require a specialist technician.

Study author Leann Tilley, PhD, of the University of Melbourne in Australia, said the test could make an impact in large-scale screening of malaria parasite carriers who do not present with the classic fever-type symptoms associated with the disease.

“In many countries, only people who display signs of malaria are treated,” Dr Tilley said. “But the problem with this approach is that some people don’t have typical flu-like symptoms associated with malaria, and this means a reservoir of parasites persists that can reemerge and spread very quickly within a community.”

“Our test works because it can detect the malaria parasite at the very early stages and can reliably detect it in an automated manner in a single red blood cell. No other test can do that.”

FPA detectors were originally developed for Javelin Portable anti-tank missiles in the 1990s. The heat-seeking detector is used on shoulder-fired missiles but can also be installed on tracked, wheeled, or amphibious vehicles, providing spatial and spectral information in a matter of seconds.

The FPA detector used in this project was coupled to a synchrotron source located at the InfraRed Environmental Imaging facility at the Synchrotron Radiation Center in Wisconsin.

For the next phase of this research, Dr Wood’s team is collaborating with Patcharee Jearanaikoon, PhD, of Kohn Kaen University in Thailand, to test the technology in clinics.

Malaria-infected cell bursting

Credit: Peter H. Seeberger

Researchers have used military technology to develop a test for detecting malaria parasites in the blood.

The team used a detector known as a focal plane array (FPA), which was originally developed for heat-seeking missiles.

The FPA gives highly detailed information on a sample area in minutes. The heat-seeking detector, which is coupled to an infrared imaging microscope, could detect the malaria parasite in a single red blood cell.

The infrared signature from the fatty acids of the parasites allowed the researchers to detect the parasite at its earliest stages and determine the number of parasites in a blood smear.

The team described the technology in Analyst.

“Our test detects malaria at its very early stages, so that doctors can stop the disease in its tracks before it takes hold and kills,” said study author Bayden Wood, PhD, of Monash University in Victoria, Australia. “We believe this sets the gold standard for malaria testing.”

“There are some excellent tests that diagnose malaria. However, the sensitivity is limited, and the best methods require hours of input from skilled microscopists, and that’s a problem in developing countries where malaria is most prevalent.”

The new test, on the other hand, gives an automatic diagnosis within 4 minutes and doesn’t require a specialist technician.

Study author Leann Tilley, PhD, of the University of Melbourne in Australia, said the test could make an impact in large-scale screening of malaria parasite carriers who do not present with the classic fever-type symptoms associated with the disease.

“In many countries, only people who display signs of malaria are treated,” Dr Tilley said. “But the problem with this approach is that some people don’t have typical flu-like symptoms associated with malaria, and this means a reservoir of parasites persists that can reemerge and spread very quickly within a community.”

“Our test works because it can detect the malaria parasite at the very early stages and can reliably detect it in an automated manner in a single red blood cell. No other test can do that.”

FPA detectors were originally developed for Javelin Portable anti-tank missiles in the 1990s. The heat-seeking detector is used on shoulder-fired missiles but can also be installed on tracked, wheeled, or amphibious vehicles, providing spatial and spectral information in a matter of seconds.

The FPA detector used in this project was coupled to a synchrotron source located at the InfraRed Environmental Imaging facility at the Synchrotron Radiation Center in Wisconsin.

For the next phase of this research, Dr Wood’s team is collaborating with Patcharee Jearanaikoon, PhD, of Kohn Kaen University in Thailand, to test the technology in clinics.

Myelodysplastic syndromes (MDS) are a heterogeneous group of hematologic neoplasms with an annual incidence of 4.1 cases per 100,000 Americans. Patients with MDS suffer from chronic cytopenias that may lead to recurrent transfusions, infections, and increased risk for bleeding. They are also at risk for progression to acute myeloid leukemia. Allogeneic hematopoietic cell transplantation is the only potentially curative treatment for MDS, although 3 drugs have been approved by the US Food and Drug Administration for its treatment: lenalidomide, 5-azacitidine, and decitabine.
 

Click on the PDF icon at the top of this introduction to read the full article.

Myelodysplastic syndromes (MDS) are a heterogeneous group of hematologic neoplasms with an annual incidence of 4.1 cases per 100,000 Americans. Patients with MDS suffer from chronic cytopenias that may lead to recurrent transfusions, infections, and increased risk for bleeding. They are also at risk for progression to acute myeloid leukemia. Allogeneic hematopoietic cell transplantation is the only potentially curative treatment for MDS, although 3 drugs have been approved by the US Food and Drug Administration for its treatment: lenalidomide, 5-azacitidine, and decitabine.
 

Click on the PDF icon at the top of this introduction to read the full article.

Myelodysplastic syndromes (MDS) are a heterogeneous group of hematologic neoplasms with an annual incidence of 4.1 cases per 100,000 Americans. Patients with MDS suffer from chronic cytopenias that may lead to recurrent transfusions, infections, and increased risk for bleeding. They are also at risk for progression to acute myeloid leukemia. Allogeneic hematopoietic cell transplantation is the only potentially curative treatment for MDS, although 3 drugs have been approved by the US Food and Drug Administration for its treatment: lenalidomide, 5-azacitidine, and decitabine.
 

Click on the PDF icon at the top of this introduction to read the full article.

Although delirium has many descriptive terms (Table 1), a common unifying term is “acute global cognitive dysfunction,” now recognized as delirium; a consensus supported by DSM-5¹ and ICD-10² (Table 2). According to DSM-5, the essential feature is a disturbance of attention or awareness that is accompanied by a change in baseline cognition that cannot be explained by another preexisting, established, or evolving neurocognitive disorder (the newly named DSM-5 entity for dementia syndromes).¹ Because delirium affects the cortex diffusely, psychiatric symp­toms can include cognitive, mood, anxiety, or psychotic symp­toms. Because many systemic illnesses can induce delirium, the differential diagnosis spans all organ systems.

Three subtypes
Delirium can be classified, based on symptoms,^3,4 into 3 sub­types: hyperactive-hyperalert, hypoactive-hypoalert, and mixed delirium. Hyperactive patients present with rest­lessness and agitation. Hypoactive patients are lethargic, confused, slow to respond to questions, and often appear depressed. The differential prognostic significance of these subtypes has been examined in the literature, with conflicting results. Rabinowitz⁵ reported that hypoactive delirium has the worst prognosis, while Marcantonio et al⁶ indicated that the hyperactive subtype is associated with the highest mortality rate. Mixed delirium, with periods of both hyperactivity and hypoactivity, is the most common type of delirium.⁷

A prodromal phase, characterized by anxiety, frequent requests for nursing and medical assistance, decreased attention, rest­lessness, vivid dreams, disorientation imme­diately after awakening, and hallucinations, can occur before an episode of full-spectrum delirium; this prodromal state often is iden­tified retrospectively —after the patient is in an episode of delirium.^8,9

Evidence-based guidelines aim to improve recognition and clinical management.^10-13 Disruptive behavior is the main reason for psychiatric referral in delirium.^14,15 Delayed psychiatric consultation because of non-recognition of delirium is related to variables such as older age; history of a pre-existing, comorbid neurocognitive disorder; and the clinical appearance of hypoactive delirium.¹⁴

The case of Mr. D (Box),¹⁶ illus­trates how the emergence of antipsychotic-associated neuroleptic malignant syndrome (NMS) can complicate antipsychotic treat­ment of delirium in a geriatric medical patient, although delirium also is a common presentation in NMS.¹⁷ Delirium developed after an increase in carbidopa/levodopa, which has central dopaminergic effects that can precipitate delirium, particularly in a geriatric patient with preexisting comorbid neurocognitive disorder. Further complicat­ing Mr. D’s delirium presentation was the development of NMS, which had a multifac­torial causation, such as the use of dopamine antagonists (ie, quetiapine, metoclopramide), and an abrupt decrease of a dopaminergic agent (ie, carbidopa/levodopa), all inducing a central dopamine relative hypoactivity.

Epidemiology
Delirium is more common in older patients,¹⁵ and is seen in 30% to 40% of hospitalized geri­atric patients.¹⁸ Delirium in older patients, compared with other adults, is associated with more severe cognitive impairment.¹⁹ It is com­mon among geriatric surgical patients (15% to 62%)²⁰ with a peak 2 to 5 days postoperatively for hip fracture,²¹ and often is seen in ICU patients (70% to 87%).²⁰ However, Spronk et al²² found that delirium is significantly under-recognized in the ICU. Nearly 90% of terminally ill patients become delirious before death.²³ Terminal delirium often is unrecognized and can interfere with assessment of other clinical problems.²⁴ A preexisting history of comor­bid neurocognitive disorder was evident in as many as two-thirds of delirium cases.²⁵

Pathophysiology and risk factors
The pathophysiology of delirium has been characterized as an imbalance of CNS metab­olism, including decreased blood flow in vari­ous regions of the brain that may normalize once delirium resolves.²⁶ Studies describe the simultaneous decrease of cholinergic transmission and dopaminergic excess.^27,28 Predisposing and precipitating factors for delirium that are of particular importance in geriatric patients include:
   • advanced age
   • CNS disease
   • infection
   • cognitive impairment
   • male sex
   • poor nutrition
   • dehydration and other metabolic abnormalities
   • cardiovascular events
   • substance use
   • medication
   • sensory deprivation (eg, impaired vision or hearing)
   • sleep deprivation
   • low level of physical activity.^27,29,30

Table 3 lists the most common delirium-provocative medications.²⁷

Evaluation and psychometric scales
The EEG can be useful in evaluating delir­ium, especially in clinically ambiguous cases. EEG findings may indicate generalized slowing or dropout of the posterior domi­nant rhythm, and generalized slow theta and delta waves, findings that are more common in delirium than in other neurocognitive dis­orders and other psychiatric illnesses. The EEG must be interpreted in the context of the delirium diagnostic workup, because abnor­malities seen in other neurocognitive disor­ders can overlap with those of delirium.³¹

The EEG referral should specify the clini­cal suspicion of delirium to help interpret the results. Delirium cases in which the patient’s previous cognitive status is unknown may benefit from EEG evaluation, such as:
   • in possible status epilepticus
   • when delirium improvement has reached a plateau at a lower level of cognitive function than before onset of delirium
   • when the patient is unable or unwilling to complete a psychiatric interview.²⁷

Assessment instruments are available to diagnose and monitor delirium (Table 4). Typically, delirium assessment includes examining levels of arousal, psychomotor activity, cognition (ie, orienta­tion, attention, and memory), and percep­tual disturbances.

Psychometrically, a review of Table 4 suggests that validity appeared stable with adequate specificity (64% to 99%) but more variable sensitivity (36% to 100%). These reliability parameters also will be affected by the classification sys­tem (ie, DSM vs ICD) and the cut-off score employed.³² Most measures (eg, Confusion Assessment Method [CAM], CAM-ICU) provide an adequate sample of behavioral (ie, level of alertness), motor (ie, psychomo­tor activity), and cognitive (ie, orientation, attention, memory, and receptive language) function, with the exception of the Global Attentiveness Rating, which is a 2-minute open conversation protocol between physi­cian and patient.

Some measures are stand-alone instru­ments, such as the Memorial Delirium Assessment Scale, whereas the CAM requires administration of separate cogni­tive screens, including the Mini-Mental State Examination (MMSE) and Digit Span.³³ Instruments to detect delirium in critically ill patients are a more recent development. Wong et al³⁴ reported that the most widely studied tool was the CAM. Obtaining collat­eral information from family, caregivers, and hospital staff is essential, particularly given the fluctuating nature of delirium.

Management
Prevention. Identify patients at high risk of delirium so that preventive strategies can be employed. Multi-component, nonphar­macotherapeutic interventions are used in clinical settings but few randomized trials have been conducted. The contributing effectiveness of individual components is not well-studied, but most include staff education to increase awareness of delir­ium. Of 3 multi-component intervention randomized trials, 2 reported a signifi­cantly lower incidence of delirium in the intervention group.^35-37 Implementation of a multi-component protocol in medical/ surgical units was associated with a sig­nificant reduction in use of restraints.³⁸

As in Mr. D’s case, complex drug regimens, particularly for CNS illness, can increase the risk of delirium. Considering the medication profile for patients with complex systemic illness—in particular, minimizing the use anticholinergics and dopamine agonists— may be crucial in preventing delirium.

Prophylactic administration of antipsychotics may reduce the risk of devel­oping postoperative delirium.³⁹ Studies of the use of these agents were characterized by small sample sizes and selected groups of patient populations. Of the 4 random­ized studies evaluating prophylactic anti­psychotics (vs placebo), 3 found a lower incidence of delirium in the intervention groups.^39-41

A study of haloperidol in post-GI sur­gery patients showed a reduced occurrence of delirium,⁴⁰ whereas its prophylactic use in patients undergoing hip surgery⁴² did not reduce the incidence of delirium com­pared with placebo, but did decrease sever­ity when delirium occurred.⁴²

Risperidone³⁹ in post-cardiac sur­gery and olanzapine⁴¹ perioperatively in patients undergoing total knee or hip replacement have been shown to decrease delirium severity and duration. Targeted prophylaxis with risperidone⁴³ in post-cardiac surgery patients who showed disturbed cognition but did not meet cri­teria for delirium reduced the number of patients requiring medication, compared with placebo.⁴³

Dexmedetomidine, an α-2 adrenergic receptor agonist, compared with propofol or midazolam in post-cardiac valve surgery patients, resulted in a decreased incidence of delirium but no difference in delirium duration, hospital length of stay, or use of other medications.⁴⁴ However, other studies have shown that dexmedetomidine reduces ICU length of stay and duration of mechani­cal ventilation.⁴⁵

Treatment. Management of hospitalized medically ill geriatric patients with delirium is challenging and requires a comprehensive approach. The first step in delirium man­agement is prompt identification and man­agement of systemic medical disturbances associated with the delirium episode. First-line, nonpharmacotherapeutic strategies for patients with delirium include:
   • reorientation
   • behavioral interventions (eg, use of clear instructions and frequent eye con­tact with patients)
   • environmental interventions (eg, mini­mal noise, adequate lighting, and lim­ited room and staff changes)
   • avoidance of physical restraints.⁴⁶

Consider employing family members or hospital staff sitters to stay with the patient and to reassure, reorient, and watch for agitation and other unsafe behaviors (eg, attempted elopement). Psychoeducation for the patient and family on the phenomenol­ogy of delirium can be helpful.

The use of drug treatment strategies should be integrated into a comprehensive approach that includes the routine use of nondrug measures.⁴⁶ Using medications for treating hypoactive delirium, formerly con­troversial, now has wider acceptance.^47,48 A few high-quality randomized trials have been performed.^25,49,50

Pharmacotherapy, especially in frail patients, should be initiated at the lowest start­ing dosage and titrated cautiously to clinical effect and for the shortest period of time nec­essary. Antipsychotics are preferred agents for treating all subtypes of delirium; haloperidol is widely used.^46,51,52 However, antipsychotics, including haloperidol, can be associated with adverse neurologic effects such as extrapyra­midal symptoms (EPS) and NMS.

Although reported less frequently than with haloperidol, other agents have been implicated in development of EPS and NMS, including atypical antipsychotics and anti­emetic dopamine antagonists, particularly in parkinsonism-prone patients.⁵³ Strategies that can minimize such risks in geriatric inpatients with delirium include oral, rather than par­enteral, use of antipsychotics—preferential use of atypical over typical antipsychotics— and lowest effective dosages.⁵⁴

In controlled trials, atypical antipsychot­ics for delirium showed efficacy compared with haloperidol.^52,55 However, there is no research that demonstrates any advantage of one atypical over another.²⁵

In Mr. D’s case, the most important inter­vention for managing delirium caused by NMS is to discontinue all dopamine antag­onists and treat agitation with judicious doses of a benzodiazepine, with supportive care.¹⁷ In cases of sudden discontinuation or a dosage decrease of dopamine agonists, these medications should be resumed or optimized to minimize the risk of NMS-associated rhabdomyolysis and subse­quent renal failure.¹⁷ Antipsychotics carry an increased risk of stroke and mortality in older patients with established or evolving neurocognitive disorders^56,57 and can cause prolongation of the QTc interval.⁵⁷

Other medications that could be used for delirium include cholinesterase inhibitors^58,59 (although larger trials and a systematic review did not support this use⁶⁰), and 5-HT receptor antagonists,⁶¹ such as trazodone. Benzodiazepines, such as lorazepam, are first-line treatment for delirium associated with seizures or withdrawal from alcohol, sedatives, hypnotics, and anxiolytics and for delirium caused by NMS. Be cautious about using benzodiazepines in geriatric patients because of a risk of respiratory depression, falls, sedation, and amnesia.

Geriatric patients with alcoholism and those with malnutrition are prone to thia­mine and vitamin B₁₂ deficiencies, which can induce delirium. Laboratory assessment and consideration of supplementation is recom­mended. Despite high occurrence of delirium in hospitalized older adults with preexisting comorbid neurocognitive disorders, there is no standard care for delirium comorbid with another neurocognitive disorder.⁶² Clinical practice guidelines for older patients receiv­ing palliative care have been developed⁶³; the goal is to minimize suffering and discomfort in patients in palliative care.⁶⁴

Post-delirium prophylaxis. Medications for delirium usually can be tapered and discontinued once the episode has resolved and the patient is stable; it is common to discontinue medications when the patient has been symptom-free for 1 week.⁶⁵ Some patients (eg, with end-stage liver disease, disseminated cancer) are prone to recur­rent or to prolonged or chronic delirium. A period of post-recovery treatment with antipsychotics—even indefinite treatment in some cases—should be considered.

Post-delirium debriefing and aftercare. The psychological complications of delirium are distressing for the patient and his (her) caregivers. Psychiatric complications asso­ciated with delirium, including acute stress disorder—which might predict posttraumatic stress disorder—have been explored; early recognition and treatment may improve long-term outcomes.⁶⁶ After recovery from acute delirium, cognitive assessment (eg, MMSE⁶⁷ or Montreal Cognitive Assessment⁶⁸) is recommended to validate current cognitive status because patients may have persistent decrement in cognitive func­tion compared with pre-delirium condition, even after recovery from the acute episode.

Post-delirium debriefing may help patients who have recovered from a delirium episode. Patients may fear that their brief period of hallucinations might represent the onset of a chronic-relapsing psychotic dis­order. Allow patients to communicate their distress about the delirium episode and give them the opportunity to talk through the experience. Brief them on the possibility that delirium will recur and advise them to seek emergency medical care in case of recur­rence. Advise patients to monitor and main­tain a normal sleep-wake cycle.

Family members can watch for syndro­mal recurrence of delirium. They should be encouraged to discuss their reaction to hav­ing seen their relative in a delirious state.

Health care systems with integrated electronic medical records should list “delirium, resolved” on the patient’s illness profile or problem list and alert the patient’s primary care provider to the delirium his­tory to avoid future exposure to delirium-provocative medications, and to prompt the provider to assume an active role in post-delirium care, including delirium recur­rence surveillance, medication adjustment, risk factor management, and post-recovery cognitive assessment.

Bottom Line
Evaluation of delirium in geriatric patients includes clinical vigilance and screening, differentiating delirium from other neurocognitive disorders, and identifying and treating underlying causes. Perioperative use of antipsychotics may reduce the incidence of delirium, although hospital length of stay generally has not been reduced with prophylaxis. Management interventions include staff education, systematic screening, use of multicomponent interventions, and pharmacologic interventions.

Related Resources
• Downing LJ, Caprio TV, Lyness JM. Geriatric psychiatry review: differential diagnosis and treatment of the 3 D’s - delirium, dementia, and depression. Curr Psychiatry Rep. 2013;15(6):365.
• Brooks PB. Postoperative delirium in elderly patients. Am J Nurs. 2012;112(9):38-49.

Drug Brand Names
Carbidopa/levodopa • Sinemet                       Midazolam •  Versed
Dexmedetomidine • Precedex                        Olanzapine •  Zyprexa
Haloperidol • Haldol                                      Propofol  •  Diprivan
Lithium • Eskalith, Lithobid                            Quetiapine  •  Seroquel
Lorazepam • Ativan                                      Risperidone  •  Risperdal
Metoclopramide •  Reglan                              Trazodone  •  Desyrel

Disclosures
The authors report no financial relationships with any company whose products are mentioned in this article or with manufacturers of competing products.

Although delirium has many descriptive terms (Table 1), a common unifying term is “acute global cognitive dysfunction,” now recognized as delirium; a consensus supported by DSM-5¹ and ICD-10² (Table 2). According to DSM-5, the essential feature is a disturbance of attention or awareness that is accompanied by a change in baseline cognition that cannot be explained by another preexisting, established, or evolving neurocognitive disorder (the newly named DSM-5 entity for dementia syndromes).¹ Because delirium affects the cortex diffusely, psychiatric symp­toms can include cognitive, mood, anxiety, or psychotic symp­toms. Because many systemic illnesses can induce delirium, the differential diagnosis spans all organ systems.

Three subtypes
Delirium can be classified, based on symptoms,^3,4 into 3 sub­types: hyperactive-hyperalert, hypoactive-hypoalert, and mixed delirium. Hyperactive patients present with rest­lessness and agitation. Hypoactive patients are lethargic, confused, slow to respond to questions, and often appear depressed. The differential prognostic significance of these subtypes has been examined in the literature, with conflicting results. Rabinowitz⁵ reported that hypoactive delirium has the worst prognosis, while Marcantonio et al⁶ indicated that the hyperactive subtype is associated with the highest mortality rate. Mixed delirium, with periods of both hyperactivity and hypoactivity, is the most common type of delirium.⁷

A prodromal phase, characterized by anxiety, frequent requests for nursing and medical assistance, decreased attention, rest­lessness, vivid dreams, disorientation imme­diately after awakening, and hallucinations, can occur before an episode of full-spectrum delirium; this prodromal state often is iden­tified retrospectively —after the patient is in an episode of delirium.^8,9

Evidence-based guidelines aim to improve recognition and clinical management.^10-13 Disruptive behavior is the main reason for psychiatric referral in delirium.^14,15 Delayed psychiatric consultation because of non-recognition of delirium is related to variables such as older age; history of a pre-existing, comorbid neurocognitive disorder; and the clinical appearance of hypoactive delirium.¹⁴

The case of Mr. D (Box),¹⁶ illus­trates how the emergence of antipsychotic-associated neuroleptic malignant syndrome (NMS) can complicate antipsychotic treat­ment of delirium in a geriatric medical patient, although delirium also is a common presentation in NMS.¹⁷ Delirium developed after an increase in carbidopa/levodopa, which has central dopaminergic effects that can precipitate delirium, particularly in a geriatric patient with preexisting comorbid neurocognitive disorder. Further complicat­ing Mr. D’s delirium presentation was the development of NMS, which had a multifac­torial causation, such as the use of dopamine antagonists (ie, quetiapine, metoclopramide), and an abrupt decrease of a dopaminergic agent (ie, carbidopa/levodopa), all inducing a central dopamine relative hypoactivity.

Epidemiology
Delirium is more common in older patients,¹⁵ and is seen in 30% to 40% of hospitalized geri­atric patients.¹⁸ Delirium in older patients, compared with other adults, is associated with more severe cognitive impairment.¹⁹ It is com­mon among geriatric surgical patients (15% to 62%)²⁰ with a peak 2 to 5 days postoperatively for hip fracture,²¹ and often is seen in ICU patients (70% to 87%).²⁰ However, Spronk et al²² found that delirium is significantly under-recognized in the ICU. Nearly 90% of terminally ill patients become delirious before death.²³ Terminal delirium often is unrecognized and can interfere with assessment of other clinical problems.²⁴ A preexisting history of comor­bid neurocognitive disorder was evident in as many as two-thirds of delirium cases.²⁵

Pathophysiology and risk factors
The pathophysiology of delirium has been characterized as an imbalance of CNS metab­olism, including decreased blood flow in vari­ous regions of the brain that may normalize once delirium resolves.²⁶ Studies describe the simultaneous decrease of cholinergic transmission and dopaminergic excess.^27,28 Predisposing and precipitating factors for delirium that are of particular importance in geriatric patients include:
   • advanced age
   • CNS disease
   • infection
   • cognitive impairment
   • male sex
   • poor nutrition
   • dehydration and other metabolic abnormalities
   • cardiovascular events
   • substance use
   • medication
   • sensory deprivation (eg, impaired vision or hearing)
   • sleep deprivation
   • low level of physical activity.^27,29,30

Table 3 lists the most common delirium-provocative medications.²⁷

Evaluation and psychometric scales
The EEG can be useful in evaluating delir­ium, especially in clinically ambiguous cases. EEG findings may indicate generalized slowing or dropout of the posterior domi­nant rhythm, and generalized slow theta and delta waves, findings that are more common in delirium than in other neurocognitive dis­orders and other psychiatric illnesses. The EEG must be interpreted in the context of the delirium diagnostic workup, because abnor­malities seen in other neurocognitive disor­ders can overlap with those of delirium.³¹

The EEG referral should specify the clini­cal suspicion of delirium to help interpret the results. Delirium cases in which the patient’s previous cognitive status is unknown may benefit from EEG evaluation, such as:
   • in possible status epilepticus
   • when delirium improvement has reached a plateau at a lower level of cognitive function than before onset of delirium
   • when the patient is unable or unwilling to complete a psychiatric interview.²⁷

Assessment instruments are available to diagnose and monitor delirium (Table 4). Typically, delirium assessment includes examining levels of arousal, psychomotor activity, cognition (ie, orienta­tion, attention, and memory), and percep­tual disturbances.

Psychometrically, a review of Table 4 suggests that validity appeared stable with adequate specificity (64% to 99%) but more variable sensitivity (36% to 100%). These reliability parameters also will be affected by the classification sys­tem (ie, DSM vs ICD) and the cut-off score employed.³² Most measures (eg, Confusion Assessment Method [CAM], CAM-ICU) provide an adequate sample of behavioral (ie, level of alertness), motor (ie, psychomo­tor activity), and cognitive (ie, orientation, attention, memory, and receptive language) function, with the exception of the Global Attentiveness Rating, which is a 2-minute open conversation protocol between physi­cian and patient.

Some measures are stand-alone instru­ments, such as the Memorial Delirium Assessment Scale, whereas the CAM requires administration of separate cogni­tive screens, including the Mini-Mental State Examination (MMSE) and Digit Span.³³ Instruments to detect delirium in critically ill patients are a more recent development. Wong et al³⁴ reported that the most widely studied tool was the CAM. Obtaining collat­eral information from family, caregivers, and hospital staff is essential, particularly given the fluctuating nature of delirium.

Management
Prevention. Identify patients at high risk of delirium so that preventive strategies can be employed. Multi-component, nonphar­macotherapeutic interventions are used in clinical settings but few randomized trials have been conducted. The contributing effectiveness of individual components is not well-studied, but most include staff education to increase awareness of delir­ium. Of 3 multi-component intervention randomized trials, 2 reported a signifi­cantly lower incidence of delirium in the intervention group.^35-37 Implementation of a multi-component protocol in medical/ surgical units was associated with a sig­nificant reduction in use of restraints.³⁸

As in Mr. D’s case, complex drug regimens, particularly for CNS illness, can increase the risk of delirium. Considering the medication profile for patients with complex systemic illness—in particular, minimizing the use anticholinergics and dopamine agonists— may be crucial in preventing delirium.

Prophylactic administration of antipsychotics may reduce the risk of devel­oping postoperative delirium.³⁹ Studies of the use of these agents were characterized by small sample sizes and selected groups of patient populations. Of the 4 random­ized studies evaluating prophylactic anti­psychotics (vs placebo), 3 found a lower incidence of delirium in the intervention groups.^39-41

A study of haloperidol in post-GI sur­gery patients showed a reduced occurrence of delirium,⁴⁰ whereas its prophylactic use in patients undergoing hip surgery⁴² did not reduce the incidence of delirium com­pared with placebo, but did decrease sever­ity when delirium occurred.⁴²

Risperidone³⁹ in post-cardiac sur­gery and olanzapine⁴¹ perioperatively in patients undergoing total knee or hip replacement have been shown to decrease delirium severity and duration. Targeted prophylaxis with risperidone⁴³ in post-cardiac surgery patients who showed disturbed cognition but did not meet cri­teria for delirium reduced the number of patients requiring medication, compared with placebo.⁴³

Dexmedetomidine, an α-2 adrenergic receptor agonist, compared with propofol or midazolam in post-cardiac valve surgery patients, resulted in a decreased incidence of delirium but no difference in delirium duration, hospital length of stay, or use of other medications.⁴⁴ However, other studies have shown that dexmedetomidine reduces ICU length of stay and duration of mechani­cal ventilation.⁴⁵

Treatment. Management of hospitalized medically ill geriatric patients with delirium is challenging and requires a comprehensive approach. The first step in delirium man­agement is prompt identification and man­agement of systemic medical disturbances associated with the delirium episode. First-line, nonpharmacotherapeutic strategies for patients with delirium include:
   • reorientation
   • behavioral interventions (eg, use of clear instructions and frequent eye con­tact with patients)
   • environmental interventions (eg, mini­mal noise, adequate lighting, and lim­ited room and staff changes)
   • avoidance of physical restraints.⁴⁶

Consider employing family members or hospital staff sitters to stay with the patient and to reassure, reorient, and watch for agitation and other unsafe behaviors (eg, attempted elopement). Psychoeducation for the patient and family on the phenomenol­ogy of delirium can be helpful.

The use of drug treatment strategies should be integrated into a comprehensive approach that includes the routine use of nondrug measures.⁴⁶ Using medications for treating hypoactive delirium, formerly con­troversial, now has wider acceptance.^47,48 A few high-quality randomized trials have been performed.^25,49,50

Pharmacotherapy, especially in frail patients, should be initiated at the lowest start­ing dosage and titrated cautiously to clinical effect and for the shortest period of time nec­essary. Antipsychotics are preferred agents for treating all subtypes of delirium; haloperidol is widely used.^46,51,52 However, antipsychotics, including haloperidol, can be associated with adverse neurologic effects such as extrapyra­midal symptoms (EPS) and NMS.

Although reported less frequently than with haloperidol, other agents have been implicated in development of EPS and NMS, including atypical antipsychotics and anti­emetic dopamine antagonists, particularly in parkinsonism-prone patients.⁵³ Strategies that can minimize such risks in geriatric inpatients with delirium include oral, rather than par­enteral, use of antipsychotics—preferential use of atypical over typical antipsychotics— and lowest effective dosages.⁵⁴

In controlled trials, atypical antipsychot­ics for delirium showed efficacy compared with haloperidol.^52,55 However, there is no research that demonstrates any advantage of one atypical over another.²⁵

In Mr. D’s case, the most important inter­vention for managing delirium caused by NMS is to discontinue all dopamine antag­onists and treat agitation with judicious doses of a benzodiazepine, with supportive care.¹⁷ In cases of sudden discontinuation or a dosage decrease of dopamine agonists, these medications should be resumed or optimized to minimize the risk of NMS-associated rhabdomyolysis and subse­quent renal failure.¹⁷ Antipsychotics carry an increased risk of stroke and mortality in older patients with established or evolving neurocognitive disorders^56,57 and can cause prolongation of the QTc interval.⁵⁷

Other medications that could be used for delirium include cholinesterase inhibitors^58,59 (although larger trials and a systematic review did not support this use⁶⁰), and 5-HT receptor antagonists,⁶¹ such as trazodone. Benzodiazepines, such as lorazepam, are first-line treatment for delirium associated with seizures or withdrawal from alcohol, sedatives, hypnotics, and anxiolytics and for delirium caused by NMS. Be cautious about using benzodiazepines in geriatric patients because of a risk of respiratory depression, falls, sedation, and amnesia.

Geriatric patients with alcoholism and those with malnutrition are prone to thia­mine and vitamin B₁₂ deficiencies, which can induce delirium. Laboratory assessment and consideration of supplementation is recom­mended. Despite high occurrence of delirium in hospitalized older adults with preexisting comorbid neurocognitive disorders, there is no standard care for delirium comorbid with another neurocognitive disorder.⁶² Clinical practice guidelines for older patients receiv­ing palliative care have been developed⁶³; the goal is to minimize suffering and discomfort in patients in palliative care.⁶⁴

Post-delirium prophylaxis. Medications for delirium usually can be tapered and discontinued once the episode has resolved and the patient is stable; it is common to discontinue medications when the patient has been symptom-free for 1 week.⁶⁵ Some patients (eg, with end-stage liver disease, disseminated cancer) are prone to recur­rent or to prolonged or chronic delirium. A period of post-recovery treatment with antipsychotics—even indefinite treatment in some cases—should be considered.

Post-delirium debriefing and aftercare. The psychological complications of delirium are distressing for the patient and his (her) caregivers. Psychiatric complications asso­ciated with delirium, including acute stress disorder—which might predict posttraumatic stress disorder—have been explored; early recognition and treatment may improve long-term outcomes.⁶⁶ After recovery from acute delirium, cognitive assessment (eg, MMSE⁶⁷ or Montreal Cognitive Assessment⁶⁸) is recommended to validate current cognitive status because patients may have persistent decrement in cognitive func­tion compared with pre-delirium condition, even after recovery from the acute episode.

Post-delirium debriefing may help patients who have recovered from a delirium episode. Patients may fear that their brief period of hallucinations might represent the onset of a chronic-relapsing psychotic dis­order. Allow patients to communicate their distress about the delirium episode and give them the opportunity to talk through the experience. Brief them on the possibility that delirium will recur and advise them to seek emergency medical care in case of recur­rence. Advise patients to monitor and main­tain a normal sleep-wake cycle.

Family members can watch for syndro­mal recurrence of delirium. They should be encouraged to discuss their reaction to hav­ing seen their relative in a delirious state.

Health care systems with integrated electronic medical records should list “delirium, resolved” on the patient’s illness profile or problem list and alert the patient’s primary care provider to the delirium his­tory to avoid future exposure to delirium-provocative medications, and to prompt the provider to assume an active role in post-delirium care, including delirium recur­rence surveillance, medication adjustment, risk factor management, and post-recovery cognitive assessment.

Bottom Line
Evaluation of delirium in geriatric patients includes clinical vigilance and screening, differentiating delirium from other neurocognitive disorders, and identifying and treating underlying causes. Perioperative use of antipsychotics may reduce the incidence of delirium, although hospital length of stay generally has not been reduced with prophylaxis. Management interventions include staff education, systematic screening, use of multicomponent interventions, and pharmacologic interventions.

Related Resources
• Downing LJ, Caprio TV, Lyness JM. Geriatric psychiatry review: differential diagnosis and treatment of the 3 D’s - delirium, dementia, and depression. Curr Psychiatry Rep. 2013;15(6):365.
• Brooks PB. Postoperative delirium in elderly patients. Am J Nurs. 2012;112(9):38-49.

Drug Brand Names
Carbidopa/levodopa • Sinemet                       Midazolam •  Versed
Dexmedetomidine • Precedex                        Olanzapine •  Zyprexa
Haloperidol • Haldol                                      Propofol  •  Diprivan
Lithium • Eskalith, Lithobid                            Quetiapine  •  Seroquel
Lorazepam • Ativan                                      Risperidone  •  Risperdal
Metoclopramide •  Reglan                              Trazodone  •  Desyrel

Disclosures
The authors report no financial relationships with any company whose products are mentioned in this article or with manufacturers of competing products.

Although delirium has many descriptive terms (Table 1), a common unifying term is “acute global cognitive dysfunction,” now recognized as delirium; a consensus supported by DSM-5¹ and ICD-10² (Table 2). According to DSM-5, the essential feature is a disturbance of attention or awareness that is accompanied by a change in baseline cognition that cannot be explained by another preexisting, established, or evolving neurocognitive disorder (the newly named DSM-5 entity for dementia syndromes).¹ Because delirium affects the cortex diffusely, psychiatric symp­toms can include cognitive, mood, anxiety, or psychotic symp­toms. Because many systemic illnesses can induce delirium, the differential diagnosis spans all organ systems.

Three subtypes
Delirium can be classified, based on symptoms,^3,4 into 3 sub­types: hyperactive-hyperalert, hypoactive-hypoalert, and mixed delirium. Hyperactive patients present with rest­lessness and agitation. Hypoactive patients are lethargic, confused, slow to respond to questions, and often appear depressed. The differential prognostic significance of these subtypes has been examined in the literature, with conflicting results. Rabinowitz⁵ reported that hypoactive delirium has the worst prognosis, while Marcantonio et al⁶ indicated that the hyperactive subtype is associated with the highest mortality rate. Mixed delirium, with periods of both hyperactivity and hypoactivity, is the most common type of delirium.⁷

A prodromal phase, characterized by anxiety, frequent requests for nursing and medical assistance, decreased attention, rest­lessness, vivid dreams, disorientation imme­diately after awakening, and hallucinations, can occur before an episode of full-spectrum delirium; this prodromal state often is iden­tified retrospectively —after the patient is in an episode of delirium.^8,9

Evidence-based guidelines aim to improve recognition and clinical management.^10-13 Disruptive behavior is the main reason for psychiatric referral in delirium.^14,15 Delayed psychiatric consultation because of non-recognition of delirium is related to variables such as older age; history of a pre-existing, comorbid neurocognitive disorder; and the clinical appearance of hypoactive delirium.¹⁴

The case of Mr. D (Box),¹⁶ illus­trates how the emergence of antipsychotic-associated neuroleptic malignant syndrome (NMS) can complicate antipsychotic treat­ment of delirium in a geriatric medical patient, although delirium also is a common presentation in NMS.¹⁷ Delirium developed after an increase in carbidopa/levodopa, which has central dopaminergic effects that can precipitate delirium, particularly in a geriatric patient with preexisting comorbid neurocognitive disorder. Further complicat­ing Mr. D’s delirium presentation was the development of NMS, which had a multifac­torial causation, such as the use of dopamine antagonists (ie, quetiapine, metoclopramide), and an abrupt decrease of a dopaminergic agent (ie, carbidopa/levodopa), all inducing a central dopamine relative hypoactivity.

Epidemiology
Delirium is more common in older patients,¹⁵ and is seen in 30% to 40% of hospitalized geri­atric patients.¹⁸ Delirium in older patients, compared with other adults, is associated with more severe cognitive impairment.¹⁹ It is com­mon among geriatric surgical patients (15% to 62%)²⁰ with a peak 2 to 5 days postoperatively for hip fracture,²¹ and often is seen in ICU patients (70% to 87%).²⁰ However, Spronk et al²² found that delirium is significantly under-recognized in the ICU. Nearly 90% of terminally ill patients become delirious before death.²³ Terminal delirium often is unrecognized and can interfere with assessment of other clinical problems.²⁴ A preexisting history of comor­bid neurocognitive disorder was evident in as many as two-thirds of delirium cases.²⁵

Pathophysiology and risk factors
The pathophysiology of delirium has been characterized as an imbalance of CNS metab­olism, including decreased blood flow in vari­ous regions of the brain that may normalize once delirium resolves.²⁶ Studies describe the simultaneous decrease of cholinergic transmission and dopaminergic excess.^27,28 Predisposing and precipitating factors for delirium that are of particular importance in geriatric patients include:
   • advanced age
   • CNS disease
   • infection
   • cognitive impairment
   • male sex
   • poor nutrition
   • dehydration and other metabolic abnormalities
   • cardiovascular events
   • substance use
   • medication
   • sensory deprivation (eg, impaired vision or hearing)
   • sleep deprivation
   • low level of physical activity.^27,29,30

Table 3 lists the most common delirium-provocative medications.²⁷

Evaluation and psychometric scales
The EEG can be useful in evaluating delir­ium, especially in clinically ambiguous cases. EEG findings may indicate generalized slowing or dropout of the posterior domi­nant rhythm, and generalized slow theta and delta waves, findings that are more common in delirium than in other neurocognitive dis­orders and other psychiatric illnesses. The EEG must be interpreted in the context of the delirium diagnostic workup, because abnor­malities seen in other neurocognitive disor­ders can overlap with those of delirium.³¹

The EEG referral should specify the clini­cal suspicion of delirium to help interpret the results. Delirium cases in which the patient’s previous cognitive status is unknown may benefit from EEG evaluation, such as:
   • in possible status epilepticus
   • when delirium improvement has reached a plateau at a lower level of cognitive function than before onset of delirium
   • when the patient is unable or unwilling to complete a psychiatric interview.²⁷

Assessment instruments are available to diagnose and monitor delirium (Table 4). Typically, delirium assessment includes examining levels of arousal, psychomotor activity, cognition (ie, orienta­tion, attention, and memory), and percep­tual disturbances.

Psychometrically, a review of Table 4 suggests that validity appeared stable with adequate specificity (64% to 99%) but more variable sensitivity (36% to 100%). These reliability parameters also will be affected by the classification sys­tem (ie, DSM vs ICD) and the cut-off score employed.³² Most measures (eg, Confusion Assessment Method [CAM], CAM-ICU) provide an adequate sample of behavioral (ie, level of alertness), motor (ie, psychomo­tor activity), and cognitive (ie, orientation, attention, memory, and receptive language) function, with the exception of the Global Attentiveness Rating, which is a 2-minute open conversation protocol between physi­cian and patient.

Some measures are stand-alone instru­ments, such as the Memorial Delirium Assessment Scale, whereas the CAM requires administration of separate cogni­tive screens, including the Mini-Mental State Examination (MMSE) and Digit Span.³³ Instruments to detect delirium in critically ill patients are a more recent development. Wong et al³⁴ reported that the most widely studied tool was the CAM. Obtaining collat­eral information from family, caregivers, and hospital staff is essential, particularly given the fluctuating nature of delirium.

Management
Prevention. Identify patients at high risk of delirium so that preventive strategies can be employed. Multi-component, nonphar­macotherapeutic interventions are used in clinical settings but few randomized trials have been conducted. The contributing effectiveness of individual components is not well-studied, but most include staff education to increase awareness of delir­ium. Of 3 multi-component intervention randomized trials, 2 reported a signifi­cantly lower incidence of delirium in the intervention group.^35-37 Implementation of a multi-component protocol in medical/ surgical units was associated with a sig­nificant reduction in use of restraints.³⁸

As in Mr. D’s case, complex drug regimens, particularly for CNS illness, can increase the risk of delirium. Considering the medication profile for patients with complex systemic illness—in particular, minimizing the use anticholinergics and dopamine agonists— may be crucial in preventing delirium.

Prophylactic administration of antipsychotics may reduce the risk of devel­oping postoperative delirium.³⁹ Studies of the use of these agents were characterized by small sample sizes and selected groups of patient populations. Of the 4 random­ized studies evaluating prophylactic anti­psychotics (vs placebo), 3 found a lower incidence of delirium in the intervention groups.^39-41

A study of haloperidol in post-GI sur­gery patients showed a reduced occurrence of delirium,⁴⁰ whereas its prophylactic use in patients undergoing hip surgery⁴² did not reduce the incidence of delirium com­pared with placebo, but did decrease sever­ity when delirium occurred.⁴²

Risperidone³⁹ in post-cardiac sur­gery and olanzapine⁴¹ perioperatively in patients undergoing total knee or hip replacement have been shown to decrease delirium severity and duration. Targeted prophylaxis with risperidone⁴³ in post-cardiac surgery patients who showed disturbed cognition but did not meet cri­teria for delirium reduced the number of patients requiring medication, compared with placebo.⁴³

Dexmedetomidine, an α-2 adrenergic receptor agonist, compared with propofol or midazolam in post-cardiac valve surgery patients, resulted in a decreased incidence of delirium but no difference in delirium duration, hospital length of stay, or use of other medications.⁴⁴ However, other studies have shown that dexmedetomidine reduces ICU length of stay and duration of mechani­cal ventilation.⁴⁵

Treatment. Management of hospitalized medically ill geriatric patients with delirium is challenging and requires a comprehensive approach. The first step in delirium man­agement is prompt identification and man­agement of systemic medical disturbances associated with the delirium episode. First-line, nonpharmacotherapeutic strategies for patients with delirium include:
   • reorientation
   • behavioral interventions (eg, use of clear instructions and frequent eye con­tact with patients)
   • environmental interventions (eg, mini­mal noise, adequate lighting, and lim­ited room and staff changes)
   • avoidance of physical restraints.⁴⁶

Consider employing family members or hospital staff sitters to stay with the patient and to reassure, reorient, and watch for agitation and other unsafe behaviors (eg, attempted elopement). Psychoeducation for the patient and family on the phenomenol­ogy of delirium can be helpful.

The use of drug treatment strategies should be integrated into a comprehensive approach that includes the routine use of nondrug measures.⁴⁶ Using medications for treating hypoactive delirium, formerly con­troversial, now has wider acceptance.^47,48 A few high-quality randomized trials have been performed.^25,49,50

Pharmacotherapy, especially in frail patients, should be initiated at the lowest start­ing dosage and titrated cautiously to clinical effect and for the shortest period of time nec­essary. Antipsychotics are preferred agents for treating all subtypes of delirium; haloperidol is widely used.^46,51,52 However, antipsychotics, including haloperidol, can be associated with adverse neurologic effects such as extrapyra­midal symptoms (EPS) and NMS.

Although reported less frequently than with haloperidol, other agents have been implicated in development of EPS and NMS, including atypical antipsychotics and anti­emetic dopamine antagonists, particularly in parkinsonism-prone patients.⁵³ Strategies that can minimize such risks in geriatric inpatients with delirium include oral, rather than par­enteral, use of antipsychotics—preferential use of atypical over typical antipsychotics— and lowest effective dosages.⁵⁴

In controlled trials, atypical antipsychot­ics for delirium showed efficacy compared with haloperidol.^52,55 However, there is no research that demonstrates any advantage of one atypical over another.²⁵

In Mr. D’s case, the most important inter­vention for managing delirium caused by NMS is to discontinue all dopamine antag­onists and treat agitation with judicious doses of a benzodiazepine, with supportive care.¹⁷ In cases of sudden discontinuation or a dosage decrease of dopamine agonists, these medications should be resumed or optimized to minimize the risk of NMS-associated rhabdomyolysis and subse­quent renal failure.¹⁷ Antipsychotics carry an increased risk of stroke and mortality in older patients with established or evolving neurocognitive disorders^56,57 and can cause prolongation of the QTc interval.⁵⁷

Other medications that could be used for delirium include cholinesterase inhibitors^58,59 (although larger trials and a systematic review did not support this use⁶⁰), and 5-HT receptor antagonists,⁶¹ such as trazodone. Benzodiazepines, such as lorazepam, are first-line treatment for delirium associated with seizures or withdrawal from alcohol, sedatives, hypnotics, and anxiolytics and for delirium caused by NMS. Be cautious about using benzodiazepines in geriatric patients because of a risk of respiratory depression, falls, sedation, and amnesia.

Geriatric patients with alcoholism and those with malnutrition are prone to thia­mine and vitamin B₁₂ deficiencies, which can induce delirium. Laboratory assessment and consideration of supplementation is recom­mended. Despite high occurrence of delirium in hospitalized older adults with preexisting comorbid neurocognitive disorders, there is no standard care for delirium comorbid with another neurocognitive disorder.⁶² Clinical practice guidelines for older patients receiv­ing palliative care have been developed⁶³; the goal is to minimize suffering and discomfort in patients in palliative care.⁶⁴

Post-delirium prophylaxis. Medications for delirium usually can be tapered and discontinued once the episode has resolved and the patient is stable; it is common to discontinue medications when the patient has been symptom-free for 1 week.⁶⁵ Some patients (eg, with end-stage liver disease, disseminated cancer) are prone to recur­rent or to prolonged or chronic delirium. A period of post-recovery treatment with antipsychotics—even indefinite treatment in some cases—should be considered.

Post-delirium debriefing and aftercare. The psychological complications of delirium are distressing for the patient and his (her) caregivers. Psychiatric complications asso­ciated with delirium, including acute stress disorder—which might predict posttraumatic stress disorder—have been explored; early recognition and treatment may improve long-term outcomes.⁶⁶ After recovery from acute delirium, cognitive assessment (eg, MMSE⁶⁷ or Montreal Cognitive Assessment⁶⁸) is recommended to validate current cognitive status because patients may have persistent decrement in cognitive func­tion compared with pre-delirium condition, even after recovery from the acute episode.

Post-delirium debriefing may help patients who have recovered from a delirium episode. Patients may fear that their brief period of hallucinations might represent the onset of a chronic-relapsing psychotic dis­order. Allow patients to communicate their distress about the delirium episode and give them the opportunity to talk through the experience. Brief them on the possibility that delirium will recur and advise them to seek emergency medical care in case of recur­rence. Advise patients to monitor and main­tain a normal sleep-wake cycle.

Family members can watch for syndro­mal recurrence of delirium. They should be encouraged to discuss their reaction to hav­ing seen their relative in a delirious state.

Health care systems with integrated electronic medical records should list “delirium, resolved” on the patient’s illness profile or problem list and alert the patient’s primary care provider to the delirium his­tory to avoid future exposure to delirium-provocative medications, and to prompt the provider to assume an active role in post-delirium care, including delirium recur­rence surveillance, medication adjustment, risk factor management, and post-recovery cognitive assessment.

Bottom Line
Evaluation of delirium in geriatric patients includes clinical vigilance and screening, differentiating delirium from other neurocognitive disorders, and identifying and treating underlying causes. Perioperative use of antipsychotics may reduce the incidence of delirium, although hospital length of stay generally has not been reduced with prophylaxis. Management interventions include staff education, systematic screening, use of multicomponent interventions, and pharmacologic interventions.

Related Resources
• Downing LJ, Caprio TV, Lyness JM. Geriatric psychiatry review: differential diagnosis and treatment of the 3 D’s - delirium, dementia, and depression. Curr Psychiatry Rep. 2013;15(6):365.
• Brooks PB. Postoperative delirium in elderly patients. Am J Nurs. 2012;112(9):38-49.

Drug Brand Names
Carbidopa/levodopa • Sinemet                       Midazolam •  Versed
Dexmedetomidine • Precedex                        Olanzapine •  Zyprexa
Haloperidol • Haldol                                      Propofol  •  Diprivan
Lithium • Eskalith, Lithobid                            Quetiapine  •  Seroquel
Lorazepam • Ativan                                      Risperidone  •  Risperdal
Metoclopramide •  Reglan                              Trazodone  •  Desyrel

Disclosures
The authors report no financial relationships with any company whose products are mentioned in this article or with manufacturers of competing products.

NEW YORK – For the first time, the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis is preparing evidence-based treatment recommendations for the diagnosis and management of the comorbidities associated with psoriatic arthritis.

"I am really excited that we are taking the initiative to treat and manage the psoriatic arthritis [PsA] patient as a whole," reported Dr. Elaine Husni, director of the Arthritis and Musculoskeletal Center at the Cleveland Clinic. The guidelines are meant to be a "platform on which to raise awareness" and foster education.

An initial set of guidelines on comorbidities was drafted at the joint meetings of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) and the Spondyloarthritis Research & Treatment Network (SPARTAN). Dr. Husni led the consensus group and fielded questions about key recommendations.

The first of these recommendations, which will undergo a process of discussion and review prior to formal adoption, states that all patients with PsA should be evaluated for cardiovascular (CV) disease. The consensus group labeled this recommendation "strong" even while conferring it with grade D evidence.

"The grade D was based on the fact that there are no outcomes data specifically in patients with psoriatic arthritis," observed Dr. Alexis R. Ogdie-Beatty, director of the Penn Psoriatic Arthritis Clinic at the University of Pennsylvania, Philadelphia. A member of the consensus group, Dr. Ogdie-Beatty suggested that benefit from CV screening is still a reasonable expectation "given the growing evidence that patients with PsA are at increased risk."

Similar "strong" recommendations but grade D evidence were given for screening for ophthalmic complications and inflammatory bowel disease. In these cases, there is good evidence for an association with PsA but limited evidence that screening will lead to improved outcome. The exception was obesity for which the group gave a B rating to the evidence for benefit from diagnosis and treatment.

Screening for diabetes was also included among recommendations, but it was given a "weak" rating and a grade D for supportive evidence.

Most of the other recommendations involved screening for various infections, such as hepatitis C virus (HCV), HIV, and tuberculosis, prior to initiating immunosuppressant therapies, particularly biologics. The level of evidence for these recommendations typically ranged between B and C even though all were given strong recommendations.

The consensus recommendations are not expected to include much detail about the specific management of comorbidities. The reason is concern about their applicability across various settings of care. It was thought that GRAPPA, as an international organization, should accommodate different types of practice. For example, the group cautioned against outlining steps of CV risk management, which may be managed by rheumatologists in some areas of the world but by specialists in others.

"We want to stay away from being minicardiologists," Dr. Husni explained. She indicated that the goal of the recommendations is to simply identify the specific types of comorbidity screening that should be considered "core recommendations" in the approach to PsA.

However, there is interest in creating a table regarding the use of specific medications for PsA treatment in the context of comorbidities. In a color-coded draft presented at the GRAPPA and SPARTAN meeting, some examples included caution in the use of NSAIDs in patients with CV disease, a need for monitoring when using cyclosporine in patients with chronic kidney disease, and a preference for etanercept over other tumor necrosis factor inhibitors in patients with HCV infection.

Overall, recommendations for comorbidities were identified as an important step in defining optimal care for PsA. According to Dr. Ogdie-Beatty, "the most important point may be to raise awareness." As these recommendations wend their way through an approval process at the organizational level, Dr. Ogdie-Beatty expressed hope that the final wording is specific enough to encourage attention to comorbidities without restricting a variety of valid approaches.

Dr. Husni reported a financial relationship with Celgene. Dr. Ogdie-Beatty had no potential conflicts of interest to report.

NEW YORK – For the first time, the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis is preparing evidence-based treatment recommendations for the diagnosis and management of the comorbidities associated with psoriatic arthritis.

"I am really excited that we are taking the initiative to treat and manage the psoriatic arthritis [PsA] patient as a whole," reported Dr. Elaine Husni, director of the Arthritis and Musculoskeletal Center at the Cleveland Clinic. The guidelines are meant to be a "platform on which to raise awareness" and foster education.

An initial set of guidelines on comorbidities was drafted at the joint meetings of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) and the Spondyloarthritis Research & Treatment Network (SPARTAN). Dr. Husni led the consensus group and fielded questions about key recommendations.

The first of these recommendations, which will undergo a process of discussion and review prior to formal adoption, states that all patients with PsA should be evaluated for cardiovascular (CV) disease. The consensus group labeled this recommendation "strong" even while conferring it with grade D evidence.

"The grade D was based on the fact that there are no outcomes data specifically in patients with psoriatic arthritis," observed Dr. Alexis R. Ogdie-Beatty, director of the Penn Psoriatic Arthritis Clinic at the University of Pennsylvania, Philadelphia. A member of the consensus group, Dr. Ogdie-Beatty suggested that benefit from CV screening is still a reasonable expectation "given the growing evidence that patients with PsA are at increased risk."

Similar "strong" recommendations but grade D evidence were given for screening for ophthalmic complications and inflammatory bowel disease. In these cases, there is good evidence for an association with PsA but limited evidence that screening will lead to improved outcome. The exception was obesity for which the group gave a B rating to the evidence for benefit from diagnosis and treatment.

Screening for diabetes was also included among recommendations, but it was given a "weak" rating and a grade D for supportive evidence.

Most of the other recommendations involved screening for various infections, such as hepatitis C virus (HCV), HIV, and tuberculosis, prior to initiating immunosuppressant therapies, particularly biologics. The level of evidence for these recommendations typically ranged between B and C even though all were given strong recommendations.

The consensus recommendations are not expected to include much detail about the specific management of comorbidities. The reason is concern about their applicability across various settings of care. It was thought that GRAPPA, as an international organization, should accommodate different types of practice. For example, the group cautioned against outlining steps of CV risk management, which may be managed by rheumatologists in some areas of the world but by specialists in others.

"We want to stay away from being minicardiologists," Dr. Husni explained. She indicated that the goal of the recommendations is to simply identify the specific types of comorbidity screening that should be considered "core recommendations" in the approach to PsA.

However, there is interest in creating a table regarding the use of specific medications for PsA treatment in the context of comorbidities. In a color-coded draft presented at the GRAPPA and SPARTAN meeting, some examples included caution in the use of NSAIDs in patients with CV disease, a need for monitoring when using cyclosporine in patients with chronic kidney disease, and a preference for etanercept over other tumor necrosis factor inhibitors in patients with HCV infection.

Overall, recommendations for comorbidities were identified as an important step in defining optimal care for PsA. According to Dr. Ogdie-Beatty, "the most important point may be to raise awareness." As these recommendations wend their way through an approval process at the organizational level, Dr. Ogdie-Beatty expressed hope that the final wording is specific enough to encourage attention to comorbidities without restricting a variety of valid approaches.

Dr. Husni reported a financial relationship with Celgene. Dr. Ogdie-Beatty had no potential conflicts of interest to report.

NEW YORK – For the first time, the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis is preparing evidence-based treatment recommendations for the diagnosis and management of the comorbidities associated with psoriatic arthritis.

"I am really excited that we are taking the initiative to treat and manage the psoriatic arthritis [PsA] patient as a whole," reported Dr. Elaine Husni, director of the Arthritis and Musculoskeletal Center at the Cleveland Clinic. The guidelines are meant to be a "platform on which to raise awareness" and foster education.

An initial set of guidelines on comorbidities was drafted at the joint meetings of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) and the Spondyloarthritis Research & Treatment Network (SPARTAN). Dr. Husni led the consensus group and fielded questions about key recommendations.

The first of these recommendations, which will undergo a process of discussion and review prior to formal adoption, states that all patients with PsA should be evaluated for cardiovascular (CV) disease. The consensus group labeled this recommendation "strong" even while conferring it with grade D evidence.

"The grade D was based on the fact that there are no outcomes data specifically in patients with psoriatic arthritis," observed Dr. Alexis R. Ogdie-Beatty, director of the Penn Psoriatic Arthritis Clinic at the University of Pennsylvania, Philadelphia. A member of the consensus group, Dr. Ogdie-Beatty suggested that benefit from CV screening is still a reasonable expectation "given the growing evidence that patients with PsA are at increased risk."

Similar "strong" recommendations but grade D evidence were given for screening for ophthalmic complications and inflammatory bowel disease. In these cases, there is good evidence for an association with PsA but limited evidence that screening will lead to improved outcome. The exception was obesity for which the group gave a B rating to the evidence for benefit from diagnosis and treatment.

Screening for diabetes was also included among recommendations, but it was given a "weak" rating and a grade D for supportive evidence.

Most of the other recommendations involved screening for various infections, such as hepatitis C virus (HCV), HIV, and tuberculosis, prior to initiating immunosuppressant therapies, particularly biologics. The level of evidence for these recommendations typically ranged between B and C even though all were given strong recommendations.

The consensus recommendations are not expected to include much detail about the specific management of comorbidities. The reason is concern about their applicability across various settings of care. It was thought that GRAPPA, as an international organization, should accommodate different types of practice. For example, the group cautioned against outlining steps of CV risk management, which may be managed by rheumatologists in some areas of the world but by specialists in others.

"We want to stay away from being minicardiologists," Dr. Husni explained. She indicated that the goal of the recommendations is to simply identify the specific types of comorbidity screening that should be considered "core recommendations" in the approach to PsA.

However, there is interest in creating a table regarding the use of specific medications for PsA treatment in the context of comorbidities. In a color-coded draft presented at the GRAPPA and SPARTAN meeting, some examples included caution in the use of NSAIDs in patients with CV disease, a need for monitoring when using cyclosporine in patients with chronic kidney disease, and a preference for etanercept over other tumor necrosis factor inhibitors in patients with HCV infection.

Overall, recommendations for comorbidities were identified as an important step in defining optimal care for PsA. According to Dr. Ogdie-Beatty, "the most important point may be to raise awareness." As these recommendations wend their way through an approval process at the organizational level, Dr. Ogdie-Beatty expressed hope that the final wording is specific enough to encourage attention to comorbidities without restricting a variety of valid approaches.

Dr. Husni reported a financial relationship with Celgene. Dr. Ogdie-Beatty had no potential conflicts of interest to report.

Case Forgetful and depressed
Mr. B, age 55, has been a patient at our clinic for 8 years, where he has been under our care for treatment-resistant depression and opi­oid addiction [read about earlier events in his case in “A life of drugs and ‘downtime’” Current Psychiatry, August 2007, p. 98-103].¹ He reports feeling intermittently depressed since his teens and has had 3 near-fatal suicide attempts.

Three years ago, Mr. B reported severe depressive symptoms and short-term memory loss, which undermined his job performance and contributed to interpersonal conflict with his wife. The episode has been continuously severe for 10 months. He was taking sertra­line, 150 mg/d, and duloxetine, 60 mg/d, for major depressive disorder (MDD) and sublin­gual buprenorphine/naloxone, 20 mg/d, for opioid dependence, which was in sustained full remission.² Mr. B scored 24/30 in the Mini- Mental State Examination, indicating mild cognitive deficit. Negative results of a com­plete routine laboratory workup rule out an organic cause for his deteriorating cognition.

How would you diagnose Mr. B’s condition at this point?
   a) treatment-resistant MDD
   b) cognitive disorder not otherwise specified
   c) opioid use disorder
   d) a and c

The authors' observations
Relapse is a core feature of substance use dis­orders (SUDs) that contributes significantly to the longstanding functional impairment in patients with a mood disorder. With the relapse rate following substance use treat­ment estimated at more than 60%,³ SUDs often are described as chronic relapsing conditions. In chronic stress, corticotropin-releasing factor (CRF) is over-sensitized; we believe that acute stress can cause an unhealthy response to an over-expressed CRF system.

To prevent relapse in patients with an over-expressed CRF system, it is crucial to manage stress. One treatment option to con­sider in preventing relapse is mindfulness-based interventions (MBI). Mindfulness has been described as “paying attention in a particular way: on purpose, in the present moment, and non-judgmentally.” In the event of a relapse, awareness and acceptance fostered by mindfulness may aid in recogniz­ing and minimizing unhealthy responses, such as negative thinking that can increase the risk of relapse.

History Remission, then relapse
Mr. B was admitted to inpatient psychiatric unit after a near-fatal suicide attempt 8 years ago and given a diagnosis of MDD recurrent, severe with­out psychotic features. Trials of sertraline, bupro­pion, trazodone, quetiapine, and aripiprazole were ineffective.

Before he presented to our clinic 8 years ago, Mr. B had been taking venlafaxine, 75 mg/d, and mirtazapine, 30 mg at bedtime. His previous outpatient psychiatrist added methylphenidate, 40 mg/d, to augment the antidepressants, but this did not alleviate Mr. B’s depression.

At age 40, he entered a methadone pro­gram, began working steadily, and got married. Five years later, he stopped methadone (it is unclear from the chart if his psychiatrist initiated this change). Mr. B’s depression persisted while using opioids and became worse after stopping methadone.

We considered electroconvulsive therapy (ECT) at the time, but switching the anti­depressant or starting ECT would address only the persistent depression; buprenor­phine/naloxone would target opioid crav­ing. We started a trial of buprenorphine/ naloxone, a partial μ opioid agonist and ĸ opioid antagonist; ĸ receptor antagonism serves as an antidepressant. He responded well to augmentation of his current regimen (mirtazapine, 30 mg at bedtime, and venlafax­ine, 225 mg/d) with buprenorphine/naloxone, 16 mg/d.^4,5 he reported no anergia and said he felt more motivated and productive.

Mr. B took buprenorphine/naloxone, 32 mg/d, for 4 years until, because of concern for daytime sedation, his outpatient psychia­trist reduced the dose to 20 mg/d. With the lower dosage of buprenorphine/naloxone ini­tiated 4 years ago, Mr. B reported irritability, anhedonia, insomnia, increased self-criticism, and decreased self-care.

How would you treat Mr. B’s depression at this point?
   a) switch to a daytime antidepressant
   b) adjust the dosage of buprenorphine/ naloxone
   c) try ECT
   d) try mindfulness-based cognitive therapy

The authors’ observations
Mindfulness meditation (MM) is a medi­tation practice that cultivates awareness. While learning MM, the practitioner inten­tionally focuses on awareness—a way of purposely paying attention to the present moment, non-judgmentally, to nurture calmness and self-acceptance. Being con­scious of what the practitioner is doing while he is doing it is the core of mindful­ness practice.⁶

Mindfulness-based interventions. We rec­ommended the following forms of MBI to treat Mr. B:  
   • Mindfulness-based cognitive therapy (MBCT). MBCT is designed to help people who suffer repeated bouts of depression and chronic unhappiness. It combines the ideas of cognitive-behavioral therapy (CBT) with MM practices and attitudes based on culti­vating mindfulness.⁷  
   • Mindfulness-based stress reduction (MBSR). MBSR brings together MM and physical/breathing exercises to relax body and mind.⁶

Chronic stress and drug addiction
The literature demonstrates a significant association between acute and chronic stress and motivation to abuse substances. Stress mobilizes the CRF system to stimulate the hypothalamic-pituitary-adrenal (HPA) axis, and extra-hypothalamic actions of CRF can kindle the neuronal circuits responsible for stress-induced anxiety, dysphoria, and drug abuse behaviors.⁸

A study to evaluate effects of mindful­ness on young adult romantic partners’ HPA responses to conflict stress showed that MM has sex-specific effects on neu­roendocrine response to interpersonal stress.⁹ Research has shown that MM practice can decrease stress, increase well-being, and affect brain structure and func­tion.¹⁰ Meta-analysis of studies of animal models and humans described how spe­cific interventions intended to encourage pro-social behavior and well-being might produce plasticity-related changes in the brain.¹¹ This work concluded that, by tak­ing responsibility for the mind and the brain by participating in regular mental exercise, plastic changes in the brain pro­moted could produce lasting beneficial consequences for social and emotional behavior.¹¹

What could be perpetuating Mr. B’s depression?
   a) psychosocial stressors
   b) over-expression of CRF gene due to psychosocial stressors
   c) a and b

Treatment Mindfulness practice
Mr. B was started on CBT to manage anxiety symptoms and cognitive distortions. After 2 months, he reports no improvements in anx­iety, depression, or cognitive distortions.

We consider MBI for Mr. B, which was devel­oped by Segal et al⁷ to help prevent relapse of depression and gain the benefits of MM. There is evidence that MBI can prevent relapse of SUDs.¹² Mr. B’s MBI practice is based on MBCT, as outlined by Segal et al.⁷ He attends biweekly, 45-minute therapy sessions at our outpatient clinic. During these sessions, MM is practiced for 10 minutes under a psychiatrist’s supervision. The MBCT manual calls for 45 minutes of MM practice but, during the 10-minute ses­sion, we instruct Mr. B to independently prac­tice MM at home. Mr. B is assessed for relapses, and drug cravings; a urine toxicology screen is performed every 6 months.

We score Mr. B’s day-to-day level of mindful­ness experience, depression, and anxiety symp­toms before starting MBI and after 8 weeks of practicing MBI (Figure 1). Mindfulness is scored with the Mindful Attention Awareness Scale (MAAS), a valid, reliable scale.¹³ The MAAS comprises 15 items designed to reflect mindfulness in everyday experiences, includ­ing awareness and attention to thoughts, emotions, actions, and physical states. Items are rated on a 6-point Likert-type scale of 1 (“almost never”) to 6 (“almost always”). A typ­ical item on MAAS is “I find myself doing things without paying attention.”

Depression and anxiety symptoms are mea­sured using the Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder Scale-7 (GAD-7) Item Scale. Mr. B scores a 23 on PHQ-9, indicating severe depression (he reports that he finds it ‘‘extremely difficult” to function) (Figure 2).

There is evidence to support the use of PHQ-9 for measurement-based care in the psychiatric population.¹⁴ PHQ-9 does not capture anxiety, which is a strong predicator of suicidal behavior; therefore, we use GAD-7 to measure the sever­ity of Mr. B’s subjective anxiety.¹⁵ He scores a 14 on GAD-7 and reports that it is “very difficult” for him to function.

Mr. B is retested after 8 weeks. During those 8 weeks, he was instructed by audio guidance in body scan technique. He practices MBI tech­niques for 45 minutes every morning between 5 AM and 6 AM.⁶

After 3 months of MBI, Mr. B is promoted at work and reports that he is handling more responsibilities. He is stressed at his new job and, subsequently, experiences a relapse of anxiety symptoms and insomnia. Partly, this is because Mr. B is not able to consistently practice MBI and misses a few outpatient appointments. In the meantime, he has difficulties with sleep and con­centration and anxiety symptoms.

The treating psychiatrist reassures Mr. B and provides support to restart MBI. He man­ages to attend outpatient clinic appointments consistently and shows interest in practicing MBI daily. Later, he reports practicing MBI con­sistently along with his routine treatment at our clinic. The timeline of Mr. B’s history and treatment are summarized in Figure 3.

The authors’ observations
Mr. B’s CRF may have been down-regulated by MBI. This, in turn, decreased his depres­sive and anxiety symptoms, thereby helping to prevent relapse of depression and sub­stance abuse. He benefited from MBI prac­tices in several areas of his life, which can be described with the acronym FACES.¹⁰

Flexible. Mr. B became more cogni­tively flexible. He started to realize that “thoughts are not facts.”⁷ This change was reflected in his relationship with his wife. His wife came to one of our sessions because she noticed significant change in his attitude toward her. Their marriage of 15 years was riddled with conflict and his wife was excited to see the improvement he achieved within the short time of prac­ticing MBI.

Adaptive. He became more adaptive to changes at the work place and reported that he is enjoying his work. This is a change from his feeling that his job was a burden, as he observed in our earlier sessions.

Coherent. He became more cognitively rational. He reported improvement in his memory and concentration. Five months after initiation of MBI and MM training, he was promoted and could cope with the stress at work.

Energized. Initially, he had said that he never wanted to be part of his extended family. During a session toward the end of the treatment, he mentioned that he made an effort to contact his extended family and reported that he found it more meaningful now to be reconnected with them.

Stable. He became more emotionally stable. He did not have the urge to use drugs and he did not relapse.

As we hypothesized, for Mr. B, practic­ing MBI was associated with abstinence from substance use, increased mindfulness, acceptance of mental health problems, and remission of psychiatric symptoms.

Bottom Line
Mindfulness-based interventions provide patients with tools to target symptoms such as poor affect regulation, poor impulse control, and rumination. Evidence supports that using MBI in addition to the usual treatment can prevent relapse of a substance use disorder.

Related Resources
• Sipe WE, Eisendrath SJ. Mindfulness-based cognitive therapy: theory and practice. Can J Psychiatry. 2012;57(2):63-69.• Lau MA, Grabovac AD. Mindfulness-based interventions: Effective for depression and anxiety. Current Psychiatry. 2009;8(12):39-55.

Drug Brand Names
Aripiprazole • Abilify                               Mirtazapine • Remeron
Buprenorphine/naloxone •                       Quetiapine • Seroquel
Suboxone              
Bupropion • Wellbutrin                            Sertraline • Zoloft
Duloxetine • Cymbalta                            Trazodone • Desyrel
Methadone • Dolophine                           Venlafaxine • Effexor
Methylphenidate • Ritalin, Concerta

Acknowledgement
The manuscript preparation of Maju Mathew Koola, MD, DPM was supported by the NIMH T32 grant MH067533-07 (PI: William T. Carpenter, MD) and the American Psychiatric Association/Kempf Fund Award for Research Development in Psychobiological Psychiatry (PI: Koola). The treating Psychiatrist PGY-5 (2011-2012) Addiction Psychiatry fellow (Dr. Varghese) was supervised by Dr. Eiger. Drs. Koola and Varghese contributed equally with the manuscript preparation and are joint first authors. Dr. Varghese received a second prize for a poster presentation of this case re­port at the 34th Indo American Psychiatric Association meeting in San Francisco, CA, May 19, 2013. Christina Mathew, MD, also contributed with manuscript preparation.

Disclosures
The authors report no financial relationship with any company whose products are mentioned in this article or with manufactures of competing products.

Case Forgetful and depressed
Mr. B, age 55, has been a patient at our clinic for 8 years, where he has been under our care for treatment-resistant depression and opi­oid addiction [read about earlier events in his case in “A life of drugs and ‘downtime’” Current Psychiatry, August 2007, p. 98-103].¹ He reports feeling intermittently depressed since his teens and has had 3 near-fatal suicide attempts.

Three years ago, Mr. B reported severe depressive symptoms and short-term memory loss, which undermined his job performance and contributed to interpersonal conflict with his wife. The episode has been continuously severe for 10 months. He was taking sertra­line, 150 mg/d, and duloxetine, 60 mg/d, for major depressive disorder (MDD) and sublin­gual buprenorphine/naloxone, 20 mg/d, for opioid dependence, which was in sustained full remission.² Mr. B scored 24/30 in the Mini- Mental State Examination, indicating mild cognitive deficit. Negative results of a com­plete routine laboratory workup rule out an organic cause for his deteriorating cognition.

How would you diagnose Mr. B’s condition at this point?
   a) treatment-resistant MDD
   b) cognitive disorder not otherwise specified
   c) opioid use disorder
   d) a and c

The authors' observations
Relapse is a core feature of substance use dis­orders (SUDs) that contributes significantly to the longstanding functional impairment in patients with a mood disorder. With the relapse rate following substance use treat­ment estimated at more than 60%,³ SUDs often are described as chronic relapsing conditions. In chronic stress, corticotropin-releasing factor (CRF) is over-sensitized; we believe that acute stress can cause an unhealthy response to an over-expressed CRF system.

To prevent relapse in patients with an over-expressed CRF system, it is crucial to manage stress. One treatment option to con­sider in preventing relapse is mindfulness-based interventions (MBI). Mindfulness has been described as “paying attention in a particular way: on purpose, in the present moment, and non-judgmentally.” In the event of a relapse, awareness and acceptance fostered by mindfulness may aid in recogniz­ing and minimizing unhealthy responses, such as negative thinking that can increase the risk of relapse.

History Remission, then relapse
Mr. B was admitted to inpatient psychiatric unit after a near-fatal suicide attempt 8 years ago and given a diagnosis of MDD recurrent, severe with­out psychotic features. Trials of sertraline, bupro­pion, trazodone, quetiapine, and aripiprazole were ineffective.

Before he presented to our clinic 8 years ago, Mr. B had been taking venlafaxine, 75 mg/d, and mirtazapine, 30 mg at bedtime. His previous outpatient psychiatrist added methylphenidate, 40 mg/d, to augment the antidepressants, but this did not alleviate Mr. B’s depression.

At age 40, he entered a methadone pro­gram, began working steadily, and got married. Five years later, he stopped methadone (it is unclear from the chart if his psychiatrist initiated this change). Mr. B’s depression persisted while using opioids and became worse after stopping methadone.

We considered electroconvulsive therapy (ECT) at the time, but switching the anti­depressant or starting ECT would address only the persistent depression; buprenor­phine/naloxone would target opioid crav­ing. We started a trial of buprenorphine/ naloxone, a partial μ opioid agonist and ĸ opioid antagonist; ĸ receptor antagonism serves as an antidepressant. He responded well to augmentation of his current regimen (mirtazapine, 30 mg at bedtime, and venlafax­ine, 225 mg/d) with buprenorphine/naloxone, 16 mg/d.^4,5 he reported no anergia and said he felt more motivated and productive.

Mr. B took buprenorphine/naloxone, 32 mg/d, for 4 years until, because of concern for daytime sedation, his outpatient psychia­trist reduced the dose to 20 mg/d. With the lower dosage of buprenorphine/naloxone ini­tiated 4 years ago, Mr. B reported irritability, anhedonia, insomnia, increased self-criticism, and decreased self-care.

How would you treat Mr. B’s depression at this point?
   a) switch to a daytime antidepressant
   b) adjust the dosage of buprenorphine/ naloxone
   c) try ECT
   d) try mindfulness-based cognitive therapy

The authors’ observations
Mindfulness meditation (MM) is a medi­tation practice that cultivates awareness. While learning MM, the practitioner inten­tionally focuses on awareness—a way of purposely paying attention to the present moment, non-judgmentally, to nurture calmness and self-acceptance. Being con­scious of what the practitioner is doing while he is doing it is the core of mindful­ness practice.⁶

Mindfulness-based interventions. We rec­ommended the following forms of MBI to treat Mr. B:  
   • Mindfulness-based cognitive therapy (MBCT). MBCT is designed to help people who suffer repeated bouts of depression and chronic unhappiness. It combines the ideas of cognitive-behavioral therapy (CBT) with MM practices and attitudes based on culti­vating mindfulness.⁷  
   • Mindfulness-based stress reduction (MBSR). MBSR brings together MM and physical/breathing exercises to relax body and mind.⁶

Chronic stress and drug addiction
The literature demonstrates a significant association between acute and chronic stress and motivation to abuse substances. Stress mobilizes the CRF system to stimulate the hypothalamic-pituitary-adrenal (HPA) axis, and extra-hypothalamic actions of CRF can kindle the neuronal circuits responsible for stress-induced anxiety, dysphoria, and drug abuse behaviors.⁸

A study to evaluate effects of mindful­ness on young adult romantic partners’ HPA responses to conflict stress showed that MM has sex-specific effects on neu­roendocrine response to interpersonal stress.⁹ Research has shown that MM practice can decrease stress, increase well-being, and affect brain structure and func­tion.¹⁰ Meta-analysis of studies of animal models and humans described how spe­cific interventions intended to encourage pro-social behavior and well-being might produce plasticity-related changes in the brain.¹¹ This work concluded that, by tak­ing responsibility for the mind and the brain by participating in regular mental exercise, plastic changes in the brain pro­moted could produce lasting beneficial consequences for social and emotional behavior.¹¹

What could be perpetuating Mr. B’s depression?
   a) psychosocial stressors
   b) over-expression of CRF gene due to psychosocial stressors
   c) a and b

Treatment Mindfulness practice
Mr. B was started on CBT to manage anxiety symptoms and cognitive distortions. After 2 months, he reports no improvements in anx­iety, depression, or cognitive distortions.

We consider MBI for Mr. B, which was devel­oped by Segal et al⁷ to help prevent relapse of depression and gain the benefits of MM. There is evidence that MBI can prevent relapse of SUDs.¹² Mr. B’s MBI practice is based on MBCT, as outlined by Segal et al.⁷ He attends biweekly, 45-minute therapy sessions at our outpatient clinic. During these sessions, MM is practiced for 10 minutes under a psychiatrist’s supervision. The MBCT manual calls for 45 minutes of MM practice but, during the 10-minute ses­sion, we instruct Mr. B to independently prac­tice MM at home. Mr. B is assessed for relapses, and drug cravings; a urine toxicology screen is performed every 6 months.

We score Mr. B’s day-to-day level of mindful­ness experience, depression, and anxiety symp­toms before starting MBI and after 8 weeks of practicing MBI (Figure 1). Mindfulness is scored with the Mindful Attention Awareness Scale (MAAS), a valid, reliable scale.¹³ The MAAS comprises 15 items designed to reflect mindfulness in everyday experiences, includ­ing awareness and attention to thoughts, emotions, actions, and physical states. Items are rated on a 6-point Likert-type scale of 1 (“almost never”) to 6 (“almost always”). A typ­ical item on MAAS is “I find myself doing things without paying attention.”

Depression and anxiety symptoms are mea­sured using the Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder Scale-7 (GAD-7) Item Scale. Mr. B scores a 23 on PHQ-9, indicating severe depression (he reports that he finds it ‘‘extremely difficult” to function) (Figure 2).

There is evidence to support the use of PHQ-9 for measurement-based care in the psychiatric population.¹⁴ PHQ-9 does not capture anxiety, which is a strong predicator of suicidal behavior; therefore, we use GAD-7 to measure the sever­ity of Mr. B’s subjective anxiety.¹⁵ He scores a 14 on GAD-7 and reports that it is “very difficult” for him to function.

Mr. B is retested after 8 weeks. During those 8 weeks, he was instructed by audio guidance in body scan technique. He practices MBI tech­niques for 45 minutes every morning between 5 AM and 6 AM.⁶

After 3 months of MBI, Mr. B is promoted at work and reports that he is handling more responsibilities. He is stressed at his new job and, subsequently, experiences a relapse of anxiety symptoms and insomnia. Partly, this is because Mr. B is not able to consistently practice MBI and misses a few outpatient appointments. In the meantime, he has difficulties with sleep and con­centration and anxiety symptoms.

The treating psychiatrist reassures Mr. B and provides support to restart MBI. He man­ages to attend outpatient clinic appointments consistently and shows interest in practicing MBI daily. Later, he reports practicing MBI con­sistently along with his routine treatment at our clinic. The timeline of Mr. B’s history and treatment are summarized in Figure 3.

The authors’ observations
Mr. B’s CRF may have been down-regulated by MBI. This, in turn, decreased his depres­sive and anxiety symptoms, thereby helping to prevent relapse of depression and sub­stance abuse. He benefited from MBI prac­tices in several areas of his life, which can be described with the acronym FACES.¹⁰

Flexible. Mr. B became more cogni­tively flexible. He started to realize that “thoughts are not facts.”⁷ This change was reflected in his relationship with his wife. His wife came to one of our sessions because she noticed significant change in his attitude toward her. Their marriage of 15 years was riddled with conflict and his wife was excited to see the improvement he achieved within the short time of prac­ticing MBI.

Adaptive. He became more adaptive to changes at the work place and reported that he is enjoying his work. This is a change from his feeling that his job was a burden, as he observed in our earlier sessions.

Coherent. He became more cognitively rational. He reported improvement in his memory and concentration. Five months after initiation of MBI and MM training, he was promoted and could cope with the stress at work.

Energized. Initially, he had said that he never wanted to be part of his extended family. During a session toward the end of the treatment, he mentioned that he made an effort to contact his extended family and reported that he found it more meaningful now to be reconnected with them.

Stable. He became more emotionally stable. He did not have the urge to use drugs and he did not relapse.

As we hypothesized, for Mr. B, practic­ing MBI was associated with abstinence from substance use, increased mindfulness, acceptance of mental health problems, and remission of psychiatric symptoms.

Bottom Line
Mindfulness-based interventions provide patients with tools to target symptoms such as poor affect regulation, poor impulse control, and rumination. Evidence supports that using MBI in addition to the usual treatment can prevent relapse of a substance use disorder.

Related Resources
• Sipe WE, Eisendrath SJ. Mindfulness-based cognitive therapy: theory and practice. Can J Psychiatry. 2012;57(2):63-69.• Lau MA, Grabovac AD. Mindfulness-based interventions: Effective for depression and anxiety. Current Psychiatry. 2009;8(12):39-55.

Drug Brand Names
Aripiprazole • Abilify                               Mirtazapine • Remeron
Buprenorphine/naloxone •                       Quetiapine • Seroquel
Suboxone              
Bupropion • Wellbutrin                            Sertraline • Zoloft
Duloxetine • Cymbalta                            Trazodone • Desyrel
Methadone • Dolophine                           Venlafaxine • Effexor
Methylphenidate • Ritalin, Concerta

Acknowledgement
The manuscript preparation of Maju Mathew Koola, MD, DPM was supported by the NIMH T32 grant MH067533-07 (PI: William T. Carpenter, MD) and the American Psychiatric Association/Kempf Fund Award for Research Development in Psychobiological Psychiatry (PI: Koola). The treating Psychiatrist PGY-5 (2011-2012) Addiction Psychiatry fellow (Dr. Varghese) was supervised by Dr. Eiger. Drs. Koola and Varghese contributed equally with the manuscript preparation and are joint first authors. Dr. Varghese received a second prize for a poster presentation of this case re­port at the 34th Indo American Psychiatric Association meeting in San Francisco, CA, May 19, 2013. Christina Mathew, MD, also contributed with manuscript preparation.

Disclosures
The authors report no financial relationship with any company whose products are mentioned in this article or with manufactures of competing products.

Case Forgetful and depressed
Mr. B, age 55, has been a patient at our clinic for 8 years, where he has been under our care for treatment-resistant depression and opi­oid addiction [read about earlier events in his case in “A life of drugs and ‘downtime’” Current Psychiatry, August 2007, p. 98-103].¹ He reports feeling intermittently depressed since his teens and has had 3 near-fatal suicide attempts.

Three years ago, Mr. B reported severe depressive symptoms and short-term memory loss, which undermined his job performance and contributed to interpersonal conflict with his wife. The episode has been continuously severe for 10 months. He was taking sertra­line, 150 mg/d, and duloxetine, 60 mg/d, for major depressive disorder (MDD) and sublin­gual buprenorphine/naloxone, 20 mg/d, for opioid dependence, which was in sustained full remission.² Mr. B scored 24/30 in the Mini- Mental State Examination, indicating mild cognitive deficit. Negative results of a com­plete routine laboratory workup rule out an organic cause for his deteriorating cognition.

How would you diagnose Mr. B’s condition at this point?
   a) treatment-resistant MDD
   b) cognitive disorder not otherwise specified
   c) opioid use disorder
   d) a and c

The authors' observations
Relapse is a core feature of substance use dis­orders (SUDs) that contributes significantly to the longstanding functional impairment in patients with a mood disorder. With the relapse rate following substance use treat­ment estimated at more than 60%,³ SUDs often are described as chronic relapsing conditions. In chronic stress, corticotropin-releasing factor (CRF) is over-sensitized; we believe that acute stress can cause an unhealthy response to an over-expressed CRF system.

To prevent relapse in patients with an over-expressed CRF system, it is crucial to manage stress. One treatment option to con­sider in preventing relapse is mindfulness-based interventions (MBI). Mindfulness has been described as “paying attention in a particular way: on purpose, in the present moment, and non-judgmentally.” In the event of a relapse, awareness and acceptance fostered by mindfulness may aid in recogniz­ing and minimizing unhealthy responses, such as negative thinking that can increase the risk of relapse.

History Remission, then relapse
Mr. B was admitted to inpatient psychiatric unit after a near-fatal suicide attempt 8 years ago and given a diagnosis of MDD recurrent, severe with­out psychotic features. Trials of sertraline, bupro­pion, trazodone, quetiapine, and aripiprazole were ineffective.

Before he presented to our clinic 8 years ago, Mr. B had been taking venlafaxine, 75 mg/d, and mirtazapine, 30 mg at bedtime. His previous outpatient psychiatrist added methylphenidate, 40 mg/d, to augment the antidepressants, but this did not alleviate Mr. B’s depression.

At age 40, he entered a methadone pro­gram, began working steadily, and got married. Five years later, he stopped methadone (it is unclear from the chart if his psychiatrist initiated this change). Mr. B’s depression persisted while using opioids and became worse after stopping methadone.

We considered electroconvulsive therapy (ECT) at the time, but switching the anti­depressant or starting ECT would address only the persistent depression; buprenor­phine/naloxone would target opioid crav­ing. We started a trial of buprenorphine/ naloxone, a partial μ opioid agonist and ĸ opioid antagonist; ĸ receptor antagonism serves as an antidepressant. He responded well to augmentation of his current regimen (mirtazapine, 30 mg at bedtime, and venlafax­ine, 225 mg/d) with buprenorphine/naloxone, 16 mg/d.^4,5 he reported no anergia and said he felt more motivated and productive.

Mr. B took buprenorphine/naloxone, 32 mg/d, for 4 years until, because of concern for daytime sedation, his outpatient psychia­trist reduced the dose to 20 mg/d. With the lower dosage of buprenorphine/naloxone ini­tiated 4 years ago, Mr. B reported irritability, anhedonia, insomnia, increased self-criticism, and decreased self-care.

How would you treat Mr. B’s depression at this point?
   a) switch to a daytime antidepressant
   b) adjust the dosage of buprenorphine/ naloxone
   c) try ECT
   d) try mindfulness-based cognitive therapy

The authors’ observations
Mindfulness meditation (MM) is a medi­tation practice that cultivates awareness. While learning MM, the practitioner inten­tionally focuses on awareness—a way of purposely paying attention to the present moment, non-judgmentally, to nurture calmness and self-acceptance. Being con­scious of what the practitioner is doing while he is doing it is the core of mindful­ness practice.⁶

Mindfulness-based interventions. We rec­ommended the following forms of MBI to treat Mr. B:  
   • Mindfulness-based cognitive therapy (MBCT). MBCT is designed to help people who suffer repeated bouts of depression and chronic unhappiness. It combines the ideas of cognitive-behavioral therapy (CBT) with MM practices and attitudes based on culti­vating mindfulness.⁷  
   • Mindfulness-based stress reduction (MBSR). MBSR brings together MM and physical/breathing exercises to relax body and mind.⁶

Chronic stress and drug addiction
The literature demonstrates a significant association between acute and chronic stress and motivation to abuse substances. Stress mobilizes the CRF system to stimulate the hypothalamic-pituitary-adrenal (HPA) axis, and extra-hypothalamic actions of CRF can kindle the neuronal circuits responsible for stress-induced anxiety, dysphoria, and drug abuse behaviors.⁸

A study to evaluate effects of mindful­ness on young adult romantic partners’ HPA responses to conflict stress showed that MM has sex-specific effects on neu­roendocrine response to interpersonal stress.⁹ Research has shown that MM practice can decrease stress, increase well-being, and affect brain structure and func­tion.¹⁰ Meta-analysis of studies of animal models and humans described how spe­cific interventions intended to encourage pro-social behavior and well-being might produce plasticity-related changes in the brain.¹¹ This work concluded that, by tak­ing responsibility for the mind and the brain by participating in regular mental exercise, plastic changes in the brain pro­moted could produce lasting beneficial consequences for social and emotional behavior.¹¹

What could be perpetuating Mr. B’s depression?
   a) psychosocial stressors
   b) over-expression of CRF gene due to psychosocial stressors
   c) a and b

Treatment Mindfulness practice
Mr. B was started on CBT to manage anxiety symptoms and cognitive distortions. After 2 months, he reports no improvements in anx­iety, depression, or cognitive distortions.

We consider MBI for Mr. B, which was devel­oped by Segal et al⁷ to help prevent relapse of depression and gain the benefits of MM. There is evidence that MBI can prevent relapse of SUDs.¹² Mr. B’s MBI practice is based on MBCT, as outlined by Segal et al.⁷ He attends biweekly, 45-minute therapy sessions at our outpatient clinic. During these sessions, MM is practiced for 10 minutes under a psychiatrist’s supervision. The MBCT manual calls for 45 minutes of MM practice but, during the 10-minute ses­sion, we instruct Mr. B to independently prac­tice MM at home. Mr. B is assessed for relapses, and drug cravings; a urine toxicology screen is performed every 6 months.

We score Mr. B’s day-to-day level of mindful­ness experience, depression, and anxiety symp­toms before starting MBI and after 8 weeks of practicing MBI (Figure 1). Mindfulness is scored with the Mindful Attention Awareness Scale (MAAS), a valid, reliable scale.¹³ The MAAS comprises 15 items designed to reflect mindfulness in everyday experiences, includ­ing awareness and attention to thoughts, emotions, actions, and physical states. Items are rated on a 6-point Likert-type scale of 1 (“almost never”) to 6 (“almost always”). A typ­ical item on MAAS is “I find myself doing things without paying attention.”

Depression and anxiety symptoms are mea­sured using the Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder Scale-7 (GAD-7) Item Scale. Mr. B scores a 23 on PHQ-9, indicating severe depression (he reports that he finds it ‘‘extremely difficult” to function) (Figure 2).

There is evidence to support the use of PHQ-9 for measurement-based care in the psychiatric population.¹⁴ PHQ-9 does not capture anxiety, which is a strong predicator of suicidal behavior; therefore, we use GAD-7 to measure the sever­ity of Mr. B’s subjective anxiety.¹⁵ He scores a 14 on GAD-7 and reports that it is “very difficult” for him to function.

Mr. B is retested after 8 weeks. During those 8 weeks, he was instructed by audio guidance in body scan technique. He practices MBI tech­niques for 45 minutes every morning between 5 AM and 6 AM.⁶

After 3 months of MBI, Mr. B is promoted at work and reports that he is handling more responsibilities. He is stressed at his new job and, subsequently, experiences a relapse of anxiety symptoms and insomnia. Partly, this is because Mr. B is not able to consistently practice MBI and misses a few outpatient appointments. In the meantime, he has difficulties with sleep and con­centration and anxiety symptoms.

The treating psychiatrist reassures Mr. B and provides support to restart MBI. He man­ages to attend outpatient clinic appointments consistently and shows interest in practicing MBI daily. Later, he reports practicing MBI con­sistently along with his routine treatment at our clinic. The timeline of Mr. B’s history and treatment are summarized in Figure 3.

The authors’ observations
Mr. B’s CRF may have been down-regulated by MBI. This, in turn, decreased his depres­sive and anxiety symptoms, thereby helping to prevent relapse of depression and sub­stance abuse. He benefited from MBI prac­tices in several areas of his life, which can be described with the acronym FACES.¹⁰

Flexible. Mr. B became more cogni­tively flexible. He started to realize that “thoughts are not facts.”⁷ This change was reflected in his relationship with his wife. His wife came to one of our sessions because she noticed significant change in his attitude toward her. Their marriage of 15 years was riddled with conflict and his wife was excited to see the improvement he achieved within the short time of prac­ticing MBI.

Adaptive. He became more adaptive to changes at the work place and reported that he is enjoying his work. This is a change from his feeling that his job was a burden, as he observed in our earlier sessions.

Coherent. He became more cognitively rational. He reported improvement in his memory and concentration. Five months after initiation of MBI and MM training, he was promoted and could cope with the stress at work.

Energized. Initially, he had said that he never wanted to be part of his extended family. During a session toward the end of the treatment, he mentioned that he made an effort to contact his extended family and reported that he found it more meaningful now to be reconnected with them.

Stable. He became more emotionally stable. He did not have the urge to use drugs and he did not relapse.

As we hypothesized, for Mr. B, practic­ing MBI was associated with abstinence from substance use, increased mindfulness, acceptance of mental health problems, and remission of psychiatric symptoms.

Bottom Line
Mindfulness-based interventions provide patients with tools to target symptoms such as poor affect regulation, poor impulse control, and rumination. Evidence supports that using MBI in addition to the usual treatment can prevent relapse of a substance use disorder.

Related Resources
• Sipe WE, Eisendrath SJ. Mindfulness-based cognitive therapy: theory and practice. Can J Psychiatry. 2012;57(2):63-69.• Lau MA, Grabovac AD. Mindfulness-based interventions: Effective for depression and anxiety. Current Psychiatry. 2009;8(12):39-55.

Drug Brand Names
Aripiprazole • Abilify                               Mirtazapine • Remeron
Buprenorphine/naloxone •                       Quetiapine • Seroquel
Suboxone              
Bupropion • Wellbutrin                            Sertraline • Zoloft
Duloxetine • Cymbalta                            Trazodone • Desyrel
Methadone • Dolophine                           Venlafaxine • Effexor
Methylphenidate • Ritalin, Concerta

Acknowledgement
The manuscript preparation of Maju Mathew Koola, MD, DPM was supported by the NIMH T32 grant MH067533-07 (PI: William T. Carpenter, MD) and the American Psychiatric Association/Kempf Fund Award for Research Development in Psychobiological Psychiatry (PI: Koola). The treating Psychiatrist PGY-5 (2011-2012) Addiction Psychiatry fellow (Dr. Varghese) was supervised by Dr. Eiger. Drs. Koola and Varghese contributed equally with the manuscript preparation and are joint first authors. Dr. Varghese received a second prize for a poster presentation of this case re­port at the 34th Indo American Psychiatric Association meeting in San Francisco, CA, May 19, 2013. Christina Mathew, MD, also contributed with manuscript preparation.

Disclosures
The authors report no financial relationship with any company whose products are mentioned in this article or with manufactures of competing products.

Mild cognitive impairment (MCI) is a transitional clinical stage between normal aging and demen­tia. Together with aging, it is considered the most significant risk factor for developing dementia, often the Alzheimer’s type.¹

MCI is a challenging neuropsychiat­ric diagnosis to discuss with patients and their family because it is characterized by overlapping features of normal aging and because of its heterogeneity of etiol­ogy, clinical presentation, and outcome.^2,3 The evolution to dementia and the lack of effective treatments for preventing or forestalling this outcome can be difficult to address—particularly when the patient is in good health and has been leading a productive life.

Successful communication is key
You can take steps to communicate in a helpful way, build a strong treatment alli­ance, and reduce the potential for the iat­rogenic effects of disclosing this diagnosis and its prognostic implications.

Clarify that your findings are consistent with the patient’s or family’s report of sustained and concerning change in cog­nition and, depending on the patient, concurrent alterations in affect, behavior, or both. Emphasize that these changes are disproportionately severe relative to expectations for the patient’s age and are not caused by psychiatric or clear-cut medical factors.

Highlight contexts in which the patient’s symptoms are likely to become more dis­ruptive and impaired, and situations in which the patient can be expected to func­tion more effectively.

Provide evidence-based support for the rate of progression of symptoms and func­tional impairment.³

Emphasize that major lifestyle adjust­ments usually are unnecessary in the absence of progression, especially for patients who are retired or not involved in endeavors that involve significant cogni­tive and executive functioning demands.

Discuss the role that cognition-enhancing medications might play in managing symptoms.⁴

Address indications for additional services, including formal psychiatric care for patients who have concomitant affec­tive or behavioral symptoms and who are highly distressed by the diagnosis. Pair these services with longitudinal monitor­ing for possible exacerbation of symptoms.

Identify psychiatric, medical, and life­style factors that can increase the risk of dementia. Depending on the patient’s history, this might include diabetes, hypertension, elevated lipid levels, obe­sity, smoking, head trauma, depres­sion, physical inactivity, and lack of intellectual stimulation.

Review compensatory strategies. In MCI predominantly amnestic type, for example, having the patient make system­atic lists for shopping and other activities of daily living, as well as establishing rou­tines for organizaton, can bolster success­ful coping.

If psychometric testing was not utilized to establish the diagnosis, discussion can include the value of performing such an assessment for a more finely tuned profile of preserved and impaired neurobehavioral functions. Such a profile can include test patterns that 1) have prognostic value with regard to the likelihood of progression to dementia and 2) establish a baseline against which you can assess stability or progression over time.⁵

Disclosure
Dr. Pollak reports no financial relationships with any company whose products are mentioned in this article or with manufacturers of competing products.

Mild cognitive impairment (MCI) is a transitional clinical stage between normal aging and demen­tia. Together with aging, it is considered the most significant risk factor for developing dementia, often the Alzheimer’s type.¹

MCI is a challenging neuropsychiat­ric diagnosis to discuss with patients and their family because it is characterized by overlapping features of normal aging and because of its heterogeneity of etiol­ogy, clinical presentation, and outcome.^2,3 The evolution to dementia and the lack of effective treatments for preventing or forestalling this outcome can be difficult to address—particularly when the patient is in good health and has been leading a productive life.

Successful communication is key
You can take steps to communicate in a helpful way, build a strong treatment alli­ance, and reduce the potential for the iat­rogenic effects of disclosing this diagnosis and its prognostic implications.

Clarify that your findings are consistent with the patient’s or family’s report of sustained and concerning change in cog­nition and, depending on the patient, concurrent alterations in affect, behavior, or both. Emphasize that these changes are disproportionately severe relative to expectations for the patient’s age and are not caused by psychiatric or clear-cut medical factors.

Highlight contexts in which the patient’s symptoms are likely to become more dis­ruptive and impaired, and situations in which the patient can be expected to func­tion more effectively.

Provide evidence-based support for the rate of progression of symptoms and func­tional impairment.³

Emphasize that major lifestyle adjust­ments usually are unnecessary in the absence of progression, especially for patients who are retired or not involved in endeavors that involve significant cogni­tive and executive functioning demands.

Discuss the role that cognition-enhancing medications might play in managing symptoms.⁴

Address indications for additional services, including formal psychiatric care for patients who have concomitant affec­tive or behavioral symptoms and who are highly distressed by the diagnosis. Pair these services with longitudinal monitor­ing for possible exacerbation of symptoms.

Identify psychiatric, medical, and life­style factors that can increase the risk of dementia. Depending on the patient’s history, this might include diabetes, hypertension, elevated lipid levels, obe­sity, smoking, head trauma, depres­sion, physical inactivity, and lack of intellectual stimulation.

Review compensatory strategies. In MCI predominantly amnestic type, for example, having the patient make system­atic lists for shopping and other activities of daily living, as well as establishing rou­tines for organizaton, can bolster success­ful coping.

If psychometric testing was not utilized to establish the diagnosis, discussion can include the value of performing such an assessment for a more finely tuned profile of preserved and impaired neurobehavioral functions. Such a profile can include test patterns that 1) have prognostic value with regard to the likelihood of progression to dementia and 2) establish a baseline against which you can assess stability or progression over time.⁵

Disclosure
Dr. Pollak reports no financial relationships with any company whose products are mentioned in this article or with manufacturers of competing products.

Mild cognitive impairment (MCI) is a transitional clinical stage between normal aging and demen­tia. Together with aging, it is considered the most significant risk factor for developing dementia, often the Alzheimer’s type.¹

MCI is a challenging neuropsychiat­ric diagnosis to discuss with patients and their family because it is characterized by overlapping features of normal aging and because of its heterogeneity of etiol­ogy, clinical presentation, and outcome.^2,3 The evolution to dementia and the lack of effective treatments for preventing or forestalling this outcome can be difficult to address—particularly when the patient is in good health and has been leading a productive life.

Successful communication is key
You can take steps to communicate in a helpful way, build a strong treatment alli­ance, and reduce the potential for the iat­rogenic effects of disclosing this diagnosis and its prognostic implications.

Clarify that your findings are consistent with the patient’s or family’s report of sustained and concerning change in cog­nition and, depending on the patient, concurrent alterations in affect, behavior, or both. Emphasize that these changes are disproportionately severe relative to expectations for the patient’s age and are not caused by psychiatric or clear-cut medical factors.

Highlight contexts in which the patient’s symptoms are likely to become more dis­ruptive and impaired, and situations in which the patient can be expected to func­tion more effectively.

Provide evidence-based support for the rate of progression of symptoms and func­tional impairment.³

Emphasize that major lifestyle adjust­ments usually are unnecessary in the absence of progression, especially for patients who are retired or not involved in endeavors that involve significant cogni­tive and executive functioning demands.

Discuss the role that cognition-enhancing medications might play in managing symptoms.⁴

Address indications for additional services, including formal psychiatric care for patients who have concomitant affec­tive or behavioral symptoms and who are highly distressed by the diagnosis. Pair these services with longitudinal monitor­ing for possible exacerbation of symptoms.

Identify psychiatric, medical, and life­style factors that can increase the risk of dementia. Depending on the patient’s history, this might include diabetes, hypertension, elevated lipid levels, obe­sity, smoking, head trauma, depres­sion, physical inactivity, and lack of intellectual stimulation.

Review compensatory strategies. In MCI predominantly amnestic type, for example, having the patient make system­atic lists for shopping and other activities of daily living, as well as establishing rou­tines for organizaton, can bolster success­ful coping.

If psychometric testing was not utilized to establish the diagnosis, discussion can include the value of performing such an assessment for a more finely tuned profile of preserved and impaired neurobehavioral functions. Such a profile can include test patterns that 1) have prognostic value with regard to the likelihood of progression to dementia and 2) establish a baseline against which you can assess stability or progression over time.⁵

Disclosure
Dr. Pollak reports no financial relationships with any company whose products are mentioned in this article or with manufacturers of competing products.

Severe and enduring anorexia ner­vosa (SE-AN) is persistent anorexia nervosa (AN) lasting for ≥7 years with or without a history of treat­ment. Evidence points to the effec­tiveness of a patient-tailored plan for treating SE-AN over any universal fix. Proper medication, therapeutic alliance, and strategic discharge planning are the ingre­dients for treating SE-AN that avoids re-hospitalization (Table).

Nutritional support and pharmacotherapy required
Comprehensive metabolic analysis and initiating nutrition should be the first pri­ority for the medical team. Starved-state patients can have electrolyte and metabolic derangements that place them at risk of fatal arrhythmias or multi-system organ failure. Do not hesitate to initiate nasogastric tube feeding under the observation of a certified nutritionist when necessary for survival. A double-blind, randomized controlled trial demonstrated the benefit of olanzap­ine compared with placebo to increase body mass index (BMI) of hospitalized AN patients. Olanzapine was titrated from 2.5 to 10 mg/d over a 13-week period, and was associated with higher patient achieve­ment of a BMI > 18.5 kg/m2.¹

Although the patient is receiving nutri­tional support in conjunction with psycho­tropic medication, the road to BMI recovery can be long. Don’t forget that SE-AN can be incapacitating. In SE-AN, the fear of gaining weight is so severe that the idea of starvation-induced death initially might seem more palatable. Although counterintuitive, as the patient recovers metabolically, self-image deteriorates. Statements praising any new weight gain can derail any therapeutic relationship.

Therapeutic alliance is key
Establishing high-quality therapeutic alliance, as measured by the Helping Relationships Questionnaire, has been shown to have a positive outcome on eating disorder symptoms and comorbid depressed mood in later phases of SE-AN treatment.^2,3 Although therapeutic alliance is individual­ized, maintaining open communication and reiterating how it is the patient’s decision to consume whole food at a level at which the feeding tube can be discontinued are good places to start treatment.

Proper discharge timing and transition to outpatient care for SE-AN patients is paramount. In multicenter studies, treat­ment ends too early in 57.8% of patients; discharge at sub-ideal BMI is linked to rehospitalization.³ Slower weight gain and delayed establishment of therapeutic alli­ance are predictors of patients who exit treatment programs too early.³ Clinicians who remain vigilant for the above metrics are less likely to feed into the unacceptably high rate of treatment failure for SE-AN.

Disclosures
The authors report no financial relationship with any company whose products are mentioned in this article or with manufacturers of competing products.

Severe and enduring anorexia ner­vosa (SE-AN) is persistent anorexia nervosa (AN) lasting for ≥7 years with or without a history of treat­ment. Evidence points to the effec­tiveness of a patient-tailored plan for treating SE-AN over any universal fix. Proper medication, therapeutic alliance, and strategic discharge planning are the ingre­dients for treating SE-AN that avoids re-hospitalization (Table).

Nutritional support and pharmacotherapy required
Comprehensive metabolic analysis and initiating nutrition should be the first pri­ority for the medical team. Starved-state patients can have electrolyte and metabolic derangements that place them at risk of fatal arrhythmias or multi-system organ failure. Do not hesitate to initiate nasogastric tube feeding under the observation of a certified nutritionist when necessary for survival. A double-blind, randomized controlled trial demonstrated the benefit of olanzap­ine compared with placebo to increase body mass index (BMI) of hospitalized AN patients. Olanzapine was titrated from 2.5 to 10 mg/d over a 13-week period, and was associated with higher patient achieve­ment of a BMI > 18.5 kg/m2.¹

Although the patient is receiving nutri­tional support in conjunction with psycho­tropic medication, the road to BMI recovery can be long. Don’t forget that SE-AN can be incapacitating. In SE-AN, the fear of gaining weight is so severe that the idea of starvation-induced death initially might seem more palatable. Although counterintuitive, as the patient recovers metabolically, self-image deteriorates. Statements praising any new weight gain can derail any therapeutic relationship.

Therapeutic alliance is key
Establishing high-quality therapeutic alliance, as measured by the Helping Relationships Questionnaire, has been shown to have a positive outcome on eating disorder symptoms and comorbid depressed mood in later phases of SE-AN treatment.^2,3 Although therapeutic alliance is individual­ized, maintaining open communication and reiterating how it is the patient’s decision to consume whole food at a level at which the feeding tube can be discontinued are good places to start treatment.

Proper discharge timing and transition to outpatient care for SE-AN patients is paramount. In multicenter studies, treat­ment ends too early in 57.8% of patients; discharge at sub-ideal BMI is linked to rehospitalization.³ Slower weight gain and delayed establishment of therapeutic alli­ance are predictors of patients who exit treatment programs too early.³ Clinicians who remain vigilant for the above metrics are less likely to feed into the unacceptably high rate of treatment failure for SE-AN.

Disclosures
The authors report no financial relationship with any company whose products are mentioned in this article or with manufacturers of competing products.

Severe and enduring anorexia ner­vosa (SE-AN) is persistent anorexia nervosa (AN) lasting for ≥7 years with or without a history of treat­ment. Evidence points to the effec­tiveness of a patient-tailored plan for treating SE-AN over any universal fix. Proper medication, therapeutic alliance, and strategic discharge planning are the ingre­dients for treating SE-AN that avoids re-hospitalization (Table).

Nutritional support and pharmacotherapy required
Comprehensive metabolic analysis and initiating nutrition should be the first pri­ority for the medical team. Starved-state patients can have electrolyte and metabolic derangements that place them at risk of fatal arrhythmias or multi-system organ failure. Do not hesitate to initiate nasogastric tube feeding under the observation of a certified nutritionist when necessary for survival. A double-blind, randomized controlled trial demonstrated the benefit of olanzap­ine compared with placebo to increase body mass index (BMI) of hospitalized AN patients. Olanzapine was titrated from 2.5 to 10 mg/d over a 13-week period, and was associated with higher patient achieve­ment of a BMI > 18.5 kg/m2.¹

Although the patient is receiving nutri­tional support in conjunction with psycho­tropic medication, the road to BMI recovery can be long. Don’t forget that SE-AN can be incapacitating. In SE-AN, the fear of gaining weight is so severe that the idea of starvation-induced death initially might seem more palatable. Although counterintuitive, as the patient recovers metabolically, self-image deteriorates. Statements praising any new weight gain can derail any therapeutic relationship.

Therapeutic alliance is key
Establishing high-quality therapeutic alliance, as measured by the Helping Relationships Questionnaire, has been shown to have a positive outcome on eating disorder symptoms and comorbid depressed mood in later phases of SE-AN treatment.^2,3 Although therapeutic alliance is individual­ized, maintaining open communication and reiterating how it is the patient’s decision to consume whole food at a level at which the feeding tube can be discontinued are good places to start treatment.

Proper discharge timing and transition to outpatient care for SE-AN patients is paramount. In multicenter studies, treat­ment ends too early in 57.8% of patients; discharge at sub-ideal BMI is linked to rehospitalization.³ Slower weight gain and delayed establishment of therapeutic alli­ance are predictors of patients who exit treatment programs too early.³ Clinicians who remain vigilant for the above metrics are less likely to feed into the unacceptably high rate of treatment failure for SE-AN.

Disclosures
The authors report no financial relationship with any company whose products are mentioned in this article or with manufacturers of competing products.