Discuss this article at www.facebook.com/CurrentPsychiatry

Dear Dr. Mossman:
My patient stopped antipsychotic medication, experienced a recurrence of paranoid schizophrenia, and now is involuntarily hospitalized. During her admission assessment, she said she had a “psychiatric advance directive.” I obtained the document, which says she refuses psychopharmacologic treatment under any circumstances. Without medication, she might take years to recover. How should I proceed?
Submitted by “Dr. Y”

Most psychiatrists who regularly practice hospital-based care know their state’s legal procedures for forcing psychotic, civilly committed patients to take medication to relieve their acute symptoms. In most jurisdictions, courts will order medication over a patient’s objection after finding that the patient lacks competence to refuse antipsychotic therapy and that the proposed treatment is in the patient’s best interest.¹

But if a patient has a psychiatric advance directive (PAD) that opposes psychotropic medication, things may become complicated. To decide what to do if a patient’s PAD precludes administering a treatment you think is necessary, you should understand:

• what PADs do
• what courts have said about PADs
• what your state’s laws say about PADs
• where and when to seek legal advice.

What are advance directives?

An advance directive (or “declaration”) for health care (ADHC) is a legal document executed by a competent individual that states preferences regarding medical treatment should that individual become incapable of making or expressing decisions.^2-4 An ADHC may be a “living will” that lays out instructions for specific health care situations or a “durable power of attorney” (DPOA) that designates a proxy decision maker, or it may include elements of both. In 1990, the U.S. Congress passed the Patient Self-Determination Act,⁵ which required health care institutions that receive Medicare or Medicaid to ask patients whether they have ADHCs and to give patients information about state laws governing ADHCs.

Modeled after medical advance directives, PADs let competent individuals declare their wishes should they need psychiatric treatment during a period of decision-making incapacity.^3,4 At least 25 states have advance directive statutes specific to psychiatry.⁶ Depending on the state, PADs may allow individuals to assert their preferences regarding psychotropic medication, electroconvulsive therapy (ECT), alternatives to hospitalization, location and length of voluntary hospitalization, the treating psychiatrist, seclusion and restraint, emergency medications, and visitors.

Prevalence and praise

The prevalence of PADs is unknown. A 2006 survey of 1,011 psychiatric outpatients in California, Florida, Illinois, Massachusetts, and North Carolina by Swanson et al⁷ found only 4% to 13% of patients previously executed a PAD. However, most participants said that if given the opportunity and assistance, they would create a PAD.⁷

Psychiatric advocacy groups have lauded the development of PADs. For example, the National Alliance on Mental Illness’ position is that “PADs should be considered as a way to empower consumers to take a more active role in their treatment, and as a way to avoid conflicts over treatment and medication issues.”⁸ Proponents suggest that PADs:

• promote autonomy
• foster communication between patients and treatment providers
• increase compliance with medication
• reduce involuntary treatment and judicial involvement.^4,8

Mental Health America launched My Plan, My Life: My Psychiatric Advance Directive in September 2011 to increase public awareness of the availability of PADs.⁹ Therefore, it is safe to assume that most psychiatrists will encounter patients with PADs.

What if a PAD blocks treatment?

What happens when an adult such as Dr. Y’s patient has a PAD that precludes effective treatment? A similar situation led to Hargrave v Vermont.¹⁰

Nancy Hargrave, a Vermont woman with schizophrenia and a history of psychiatric hospitalizations, executed a DPOA—Vermont does not have a separate statute for PADs—in which she explicitly refused “any and all anti-psychotic, neuroleptic, psychotropic, or psychoactive medications,” and ECT.¹⁰

In anticipation of situations like this, Vermont’s legislature passed Act 114, a 1998 state law that required caregivers to abide by the DPOAs of civilly committed individuals and mentally ill prisoners for 45 days.¹⁰ After this time, a court may override the advance directive and allow involuntary medication administration if a patient “ha[d] not experienced a significant clinical improvement in his or her mental state, and remain[ed] incompetent.”¹⁰

In 1999, Hargrave sued the state of Vermont and other parties in federal court, alleging that Act 114 constituted discrimination under Title II of the Americans with Disabilities Act¹¹ because Act 114 excluded her from participating in the “services, programs, or activities of a public entity,” namely, the use of her DPOA under Vermont state law.¹⁰ The federal district court sided with Hargrave, concluding that “Act 114 was facially discriminatory against mentally disabled individuals.” One year later, the U.S. Court of Appeals for the Second Circuit affirmed the district court’s ruling.

Surprisingly, no other court has adjudicated this issue. However, in Second Circuit states—Vermont, New York, and Connecticut—DPOAs of mentally ill patients cannot be abrogated. This is an unsettling notion for many psychiatrists, because, as Paul Appelbaum, MD, explains, “Advance directives may now constitute an ironclad bulwark against future involuntary treatment with medication—except in emergencies—even for incompetent, committed patients and even when the alternative is long-term institutional care.”¹² Other scholars have pointed out that giving physicians an avenue to override or disregard patients’ directives would negate their intended purpose, which is to have one’s competently expressed wishes followed when one’s decision-making capacity is compromised.^6,13

Doctors’ duties

How you should respond to an involuntary patient’s PAD depends on which state you practice in. A physician’s obligation to comply with a patient’s PAD depends on state law, and most states with PAD laws provide some latitude or options if physicians believe they should not comply with a patient’s wishes.^6,13Table 1^14-18 cites examples of statutory language regarding a physician’s duty to comply with a PAD.

A survey of 164 psychiatrists in North Carolina provides some insight into psychiatrists’ perceptions of PADs.¹⁹ After reading a hypothetical scenario about a mentally ill individual whose PAD expressed refusal of hospitalization or treatment with antipsychotics, 47% of the psychiatrists chose to override the PAD. The authors found that “PAD override was more likely among psychiatrists who worked in hospital emergency departments; those who were concerned about patients’ violence risk and lack of insight; and those who were legally defensive.”

In addition to addressing conflicts between patients’ PADs and doctors’ views about proper treatment, some state laws also contain clauses that spell out the limits of physician liability in cases of physician compliance or noncompliance with PADs. Excerpts from 2 such laws appear in Table 2.^16-17

Table 1

Examples of state laws on compliance with psychiatric advance directives

Table 2

Excerpts from state laws on PAD-related liability

Related Resources

• National Resource Center on Psychiatric Advance Directives. www.nrc-pad.org.
• Duke University Program on Psychiatric Advance Directives. http://pad.duhs.duke.edu.
• Hung EK, McNiel DE, Binder RL. Covert medication in psychiatric emergencies: is it ever ethically permissible? J Am Acad Psychiatry Law. 2012;40(2):239-245.

Disclosure

The authors report no financial relationship with any company whose products are mentioned in this article or with manufacturers of competing products.

Discuss this article at www.facebook.com/CurrentPsychiatry

Dear Dr. Mossman:
My patient stopped antipsychotic medication, experienced a recurrence of paranoid schizophrenia, and now is involuntarily hospitalized. During her admission assessment, she said she had a “psychiatric advance directive.” I obtained the document, which says she refuses psychopharmacologic treatment under any circumstances. Without medication, she might take years to recover. How should I proceed?
Submitted by “Dr. Y”

Most psychiatrists who regularly practice hospital-based care know their state’s legal procedures for forcing psychotic, civilly committed patients to take medication to relieve their acute symptoms. In most jurisdictions, courts will order medication over a patient’s objection after finding that the patient lacks competence to refuse antipsychotic therapy and that the proposed treatment is in the patient’s best interest.¹

But if a patient has a psychiatric advance directive (PAD) that opposes psychotropic medication, things may become complicated. To decide what to do if a patient’s PAD precludes administering a treatment you think is necessary, you should understand:

• what PADs do
• what courts have said about PADs
• what your state’s laws say about PADs
• where and when to seek legal advice.

What are advance directives?

An advance directive (or “declaration”) for health care (ADHC) is a legal document executed by a competent individual that states preferences regarding medical treatment should that individual become incapable of making or expressing decisions.^2-4 An ADHC may be a “living will” that lays out instructions for specific health care situations or a “durable power of attorney” (DPOA) that designates a proxy decision maker, or it may include elements of both. In 1990, the U.S. Congress passed the Patient Self-Determination Act,⁵ which required health care institutions that receive Medicare or Medicaid to ask patients whether they have ADHCs and to give patients information about state laws governing ADHCs.

Modeled after medical advance directives, PADs let competent individuals declare their wishes should they need psychiatric treatment during a period of decision-making incapacity.^3,4 At least 25 states have advance directive statutes specific to psychiatry.⁶ Depending on the state, PADs may allow individuals to assert their preferences regarding psychotropic medication, electroconvulsive therapy (ECT), alternatives to hospitalization, location and length of voluntary hospitalization, the treating psychiatrist, seclusion and restraint, emergency medications, and visitors.

Prevalence and praise

The prevalence of PADs is unknown. A 2006 survey of 1,011 psychiatric outpatients in California, Florida, Illinois, Massachusetts, and North Carolina by Swanson et al⁷ found only 4% to 13% of patients previously executed a PAD. However, most participants said that if given the opportunity and assistance, they would create a PAD.⁷

Psychiatric advocacy groups have lauded the development of PADs. For example, the National Alliance on Mental Illness’ position is that “PADs should be considered as a way to empower consumers to take a more active role in their treatment, and as a way to avoid conflicts over treatment and medication issues.”⁸ Proponents suggest that PADs:

• promote autonomy
• foster communication between patients and treatment providers
• increase compliance with medication
• reduce involuntary treatment and judicial involvement.^4,8

Mental Health America launched My Plan, My Life: My Psychiatric Advance Directive in September 2011 to increase public awareness of the availability of PADs.⁹ Therefore, it is safe to assume that most psychiatrists will encounter patients with PADs.

What if a PAD blocks treatment?

What happens when an adult such as Dr. Y’s patient has a PAD that precludes effective treatment? A similar situation led to Hargrave v Vermont.¹⁰

Nancy Hargrave, a Vermont woman with schizophrenia and a history of psychiatric hospitalizations, executed a DPOA—Vermont does not have a separate statute for PADs—in which she explicitly refused “any and all anti-psychotic, neuroleptic, psychotropic, or psychoactive medications,” and ECT.¹⁰

In anticipation of situations like this, Vermont’s legislature passed Act 114, a 1998 state law that required caregivers to abide by the DPOAs of civilly committed individuals and mentally ill prisoners for 45 days.¹⁰ After this time, a court may override the advance directive and allow involuntary medication administration if a patient “ha[d] not experienced a significant clinical improvement in his or her mental state, and remain[ed] incompetent.”¹⁰

In 1999, Hargrave sued the state of Vermont and other parties in federal court, alleging that Act 114 constituted discrimination under Title II of the Americans with Disabilities Act¹¹ because Act 114 excluded her from participating in the “services, programs, or activities of a public entity,” namely, the use of her DPOA under Vermont state law.¹⁰ The federal district court sided with Hargrave, concluding that “Act 114 was facially discriminatory against mentally disabled individuals.” One year later, the U.S. Court of Appeals for the Second Circuit affirmed the district court’s ruling.

Surprisingly, no other court has adjudicated this issue. However, in Second Circuit states—Vermont, New York, and Connecticut—DPOAs of mentally ill patients cannot be abrogated. This is an unsettling notion for many psychiatrists, because, as Paul Appelbaum, MD, explains, “Advance directives may now constitute an ironclad bulwark against future involuntary treatment with medication—except in emergencies—even for incompetent, committed patients and even when the alternative is long-term institutional care.”¹² Other scholars have pointed out that giving physicians an avenue to override or disregard patients’ directives would negate their intended purpose, which is to have one’s competently expressed wishes followed when one’s decision-making capacity is compromised.^6,13

Doctors’ duties

How you should respond to an involuntary patient’s PAD depends on which state you practice in. A physician’s obligation to comply with a patient’s PAD depends on state law, and most states with PAD laws provide some latitude or options if physicians believe they should not comply with a patient’s wishes.^6,13Table 1^14-18 cites examples of statutory language regarding a physician’s duty to comply with a PAD.

A survey of 164 psychiatrists in North Carolina provides some insight into psychiatrists’ perceptions of PADs.¹⁹ After reading a hypothetical scenario about a mentally ill individual whose PAD expressed refusal of hospitalization or treatment with antipsychotics, 47% of the psychiatrists chose to override the PAD. The authors found that “PAD override was more likely among psychiatrists who worked in hospital emergency departments; those who were concerned about patients’ violence risk and lack of insight; and those who were legally defensive.”

In addition to addressing conflicts between patients’ PADs and doctors’ views about proper treatment, some state laws also contain clauses that spell out the limits of physician liability in cases of physician compliance or noncompliance with PADs. Excerpts from 2 such laws appear in Table 2.^16-17

Table 1

Examples of state laws on compliance with psychiatric advance directives

Table 2

Excerpts from state laws on PAD-related liability

Related Resources

• National Resource Center on Psychiatric Advance Directives. www.nrc-pad.org.
• Duke University Program on Psychiatric Advance Directives. http://pad.duhs.duke.edu.
• Hung EK, McNiel DE, Binder RL. Covert medication in psychiatric emergencies: is it ever ethically permissible? J Am Acad Psychiatry Law. 2012;40(2):239-245.

Disclosure

The authors report no financial relationship with any company whose products are mentioned in this article or with manufacturers of competing products.

Discuss this article at www.facebook.com/CurrentPsychiatry

Dear Dr. Mossman:
My patient stopped antipsychotic medication, experienced a recurrence of paranoid schizophrenia, and now is involuntarily hospitalized. During her admission assessment, she said she had a “psychiatric advance directive.” I obtained the document, which says she refuses psychopharmacologic treatment under any circumstances. Without medication, she might take years to recover. How should I proceed?
Submitted by “Dr. Y”

Most psychiatrists who regularly practice hospital-based care know their state’s legal procedures for forcing psychotic, civilly committed patients to take medication to relieve their acute symptoms. In most jurisdictions, courts will order medication over a patient’s objection after finding that the patient lacks competence to refuse antipsychotic therapy and that the proposed treatment is in the patient’s best interest.¹

But if a patient has a psychiatric advance directive (PAD) that opposes psychotropic medication, things may become complicated. To decide what to do if a patient’s PAD precludes administering a treatment you think is necessary, you should understand:

• what PADs do
• what courts have said about PADs
• what your state’s laws say about PADs
• where and when to seek legal advice.

What are advance directives?

An advance directive (or “declaration”) for health care (ADHC) is a legal document executed by a competent individual that states preferences regarding medical treatment should that individual become incapable of making or expressing decisions.^2-4 An ADHC may be a “living will” that lays out instructions for specific health care situations or a “durable power of attorney” (DPOA) that designates a proxy decision maker, or it may include elements of both. In 1990, the U.S. Congress passed the Patient Self-Determination Act,⁵ which required health care institutions that receive Medicare or Medicaid to ask patients whether they have ADHCs and to give patients information about state laws governing ADHCs.

Modeled after medical advance directives, PADs let competent individuals declare their wishes should they need psychiatric treatment during a period of decision-making incapacity.^3,4 At least 25 states have advance directive statutes specific to psychiatry.⁶ Depending on the state, PADs may allow individuals to assert their preferences regarding psychotropic medication, electroconvulsive therapy (ECT), alternatives to hospitalization, location and length of voluntary hospitalization, the treating psychiatrist, seclusion and restraint, emergency medications, and visitors.

Prevalence and praise

The prevalence of PADs is unknown. A 2006 survey of 1,011 psychiatric outpatients in California, Florida, Illinois, Massachusetts, and North Carolina by Swanson et al⁷ found only 4% to 13% of patients previously executed a PAD. However, most participants said that if given the opportunity and assistance, they would create a PAD.⁷

Psychiatric advocacy groups have lauded the development of PADs. For example, the National Alliance on Mental Illness’ position is that “PADs should be considered as a way to empower consumers to take a more active role in their treatment, and as a way to avoid conflicts over treatment and medication issues.”⁸ Proponents suggest that PADs:

• promote autonomy
• foster communication between patients and treatment providers
• increase compliance with medication
• reduce involuntary treatment and judicial involvement.^4,8

Mental Health America launched My Plan, My Life: My Psychiatric Advance Directive in September 2011 to increase public awareness of the availability of PADs.⁹ Therefore, it is safe to assume that most psychiatrists will encounter patients with PADs.

What if a PAD blocks treatment?

What happens when an adult such as Dr. Y’s patient has a PAD that precludes effective treatment? A similar situation led to Hargrave v Vermont.¹⁰

Nancy Hargrave, a Vermont woman with schizophrenia and a history of psychiatric hospitalizations, executed a DPOA—Vermont does not have a separate statute for PADs—in which she explicitly refused “any and all anti-psychotic, neuroleptic, psychotropic, or psychoactive medications,” and ECT.¹⁰

In anticipation of situations like this, Vermont’s legislature passed Act 114, a 1998 state law that required caregivers to abide by the DPOAs of civilly committed individuals and mentally ill prisoners for 45 days.¹⁰ After this time, a court may override the advance directive and allow involuntary medication administration if a patient “ha[d] not experienced a significant clinical improvement in his or her mental state, and remain[ed] incompetent.”¹⁰

In 1999, Hargrave sued the state of Vermont and other parties in federal court, alleging that Act 114 constituted discrimination under Title II of the Americans with Disabilities Act¹¹ because Act 114 excluded her from participating in the “services, programs, or activities of a public entity,” namely, the use of her DPOA under Vermont state law.¹⁰ The federal district court sided with Hargrave, concluding that “Act 114 was facially discriminatory against mentally disabled individuals.” One year later, the U.S. Court of Appeals for the Second Circuit affirmed the district court’s ruling.

Surprisingly, no other court has adjudicated this issue. However, in Second Circuit states—Vermont, New York, and Connecticut—DPOAs of mentally ill patients cannot be abrogated. This is an unsettling notion for many psychiatrists, because, as Paul Appelbaum, MD, explains, “Advance directives may now constitute an ironclad bulwark against future involuntary treatment with medication—except in emergencies—even for incompetent, committed patients and even when the alternative is long-term institutional care.”¹² Other scholars have pointed out that giving physicians an avenue to override or disregard patients’ directives would negate their intended purpose, which is to have one’s competently expressed wishes followed when one’s decision-making capacity is compromised.^6,13

Doctors’ duties

How you should respond to an involuntary patient’s PAD depends on which state you practice in. A physician’s obligation to comply with a patient’s PAD depends on state law, and most states with PAD laws provide some latitude or options if physicians believe they should not comply with a patient’s wishes.^6,13Table 1^14-18 cites examples of statutory language regarding a physician’s duty to comply with a PAD.

A survey of 164 psychiatrists in North Carolina provides some insight into psychiatrists’ perceptions of PADs.¹⁹ After reading a hypothetical scenario about a mentally ill individual whose PAD expressed refusal of hospitalization or treatment with antipsychotics, 47% of the psychiatrists chose to override the PAD. The authors found that “PAD override was more likely among psychiatrists who worked in hospital emergency departments; those who were concerned about patients’ violence risk and lack of insight; and those who were legally defensive.”

In addition to addressing conflicts between patients’ PADs and doctors’ views about proper treatment, some state laws also contain clauses that spell out the limits of physician liability in cases of physician compliance or noncompliance with PADs. Excerpts from 2 such laws appear in Table 2.^16-17

Table 1

Examples of state laws on compliance with psychiatric advance directives

Table 2

Excerpts from state laws on PAD-related liability

Related Resources

• National Resource Center on Psychiatric Advance Directives. www.nrc-pad.org.
• Duke University Program on Psychiatric Advance Directives. http://pad.duhs.duke.edu.
• Hung EK, McNiel DE, Binder RL. Covert medication in psychiatric emergencies: is it ever ethically permissible? J Am Acad Psychiatry Law. 2012;40(2):239-245.

Disclosure

The authors report no financial relationship with any company whose products are mentioned in this article or with manufacturers of competing products.

A review of the patient’s blood pressure since admission indicated consistently elevated systolic and diastolic pressures, on average, of 170/105 mm Hg. Additionally, his serum potassium levels ranged from 2.4 to 3.1 mmol/L (normal 3.5-5.1 mmol/L).

A detailed medical history and review of previous records revealed that an initial diagnosis of hypertension had been made during a routine sports physical at age 14, although the patient was cleared for full activity. Over the previous year, the patient said he had gained weight—much of it in the abdomen—and experienced sleep disturbances, increasing fatigability, muscle weakness, hair loss, and declining performance in his high school sports. In addition, he had noticed increased facial flushing and sweating.

On physical exam, we noted an obese male (height 5’5’’, weight 191.5 lb, BMI 30.86 kg/m²) with the following vital signs: temperature 97.9°F, pulse 105 bpm, and blood pressure 177/111 mm Hg. Pertinent physical exam findings outside of his surgical site included diffusely thinning hair, moon facies, facial plethora, increased supraclavicular and dorsocervical fat pads, thoracic and abdominal striae, thinned skin overlying his upper and lower extremities, and lower extremity edema ( FIGURE 1 ). All other exam findings were within normal limits.

Initial blood chemistry lab results revealed hyperglycemia (290 mg/dL; random normal, <200 mg/dL), hypokalemia (3.0 mmol/L; normal, 3.5-5.4 mmol/L), hypochloremia (96 mmol/L; normal, 98-107 mmol/L), and a mean corpuscular volume of 101.2 fL (normal, 80-100 fL). The patient also had a white blood cell (WBC) count of 14,400/mcL with a predominance of neutrophils and 6 bands, and a high sensitivity C-reactive protein level of 7.5 mg/dL (normal, <0.748 mg/dL).

FIGURE 1
The signs were all there

WHAT ADDITIONAL TESTING WOULD YOU ORDER?
WHAT IS YOUR PRESUMPTIVE DIAGNOSIS?

Suspecting Cushing’s syndrome, we ordered cortisol and ACTH

Based on our initial findings, we ordered a 24-hour urinary free cortisol and plasma adrenocorticotropic hormone (ACTH) level—both of which had to be sent to outside laboratories. We also ordered a computed tomography (CT) scan of the patient’s adrenal glands and magnetic resonance imaging (MRI) of his pituitary gland.

The CT scan revealed mild hyperplasia of the adrenal glands bilaterally; the MRI demonstrated a 7 × 6 × 6 mm pituitary microadenoma ( FIGURE 2 ) in the anterior portion of the gland. In addition, a 6 × 6 × 1 mm lesion was noted—thought to be a Rathke’s cleft (Pars intermedia) cyst by the reviewing radiologist.

The patient’s initial cortisol and ACTH lab work revealed a urinary cortisol level of 5089.2 mcg/24 h (normal, 3-55 mcg/24 h) and an ACTH level of 216 pg/mL (normal, 9-57 pg/mL for ages 3-17 years).

We diagnosed Cushing’s syndrome in this patient.

FIGURE 2
MRI reveals pituitary microadenoma

Differentiating between ACTH-dependent and -independent Cushing’s syndrome
Cushing’s syndrome is a constellation of signs and symptoms caused by an overproduction of cortisol, which results in a variety of abnormalities in the hypothalamic-pituitary-adrenal axis. In general, the syndrome is differentiated as either ACTH-dependent or ACTH-independent, based on the underlying cause.¹ Examples of ACTH-dependent Cushing’s syndrome include pituitary adenoma (formally classified as Cushing’s disease) and ectopic ACTH or corticotrophin-releasing hormone-producing tumors. Examples of ACTH-independent Cushing’s syndrome include adrenal adenoma or carcinoma and exogenous glucocorticoid therapy.²

Clinical manifestations include obesity, hypertension (usually with some degree of concurrent hypokalemia), skin abnormalities (eg, plethora, hirsutism, violaceous striae), musculoskeletal weakness, neuropsychiatric symptoms (eg, depression), gonadal dysfunction, and metabolic derangements, including glucose intolerance, diabetes, and hyperlipidemia. In children, a near universal decrease in linear growth secondary to hypercortisolism is seen.³

Investigating a suspected case of Cushing’s syndrome can be divided into 2 stages: confirming the diagnosis and establishing the etiology. The following tests can be used to make the diagnosis: 24-hour urinary free cortisol, low-dose dexamethasone suppression, and late-night salivary cortisol. Several of these tests require late-night administration that necessitates hospital admission. These tests are typically followed by a CT scan of the patient’s adrenal glands and/or an MRI of the patient’s pituitary gland to evaluate the etiology. Additionally, as demonstrated by the patient described here, ongoing issues with hypertension, metabolic abnormalities, and hyperglycemia may require intensive intervention and management.⁴

Don't be fooled
Potential complications in diagnosing the syndrome, however, can cloud an accurate diagnosis—especially early in the disease process. In addition to biochemical similarities between Cushing’s syndrome and obesity, depression, and alcoholism, ACTH-dependent Cushing’s syndrome can undergo cyclical or intermittent activity and can remain in remission for years.¹ Also, ectopic ACTH-secreting tumors may, by virtue of their small size and location, go undetected.

Don’t try to lower BP through usual means
Hypertension, a hallmark finding in approximately 80% of adults and 47% of children with Cushing’s syndrome,⁵ stems from hypercortisol-driven pathologic changes in the mechanisms controlling plasma volume, peripheral vascular resistance, and cardiac output. In addition, these cortisol-driven changes have a direct effect on mineralocorticoid and glucocorticoid receptors within the central nervous system. Secondary effects such as insulin resistance and the development of sleep apnea further complicate the management of this generally treatment-resistant hypertension. Lastly, specific mechanisms such as the cross-reactivity of excess glucocorticoids with mineralocorticoid receptors acting on targets within the kidney, can also lead to metabolic derangements, such as profound hypokalemia and metabolic alkalosis.

Thus, controlling hypertension and the metabolic changes seen in Cushing’s syndrome often requires addressing the underlying hypercortisolism rather than achieving normotension and normal serum electrolytes through the usual means.⁵

Treatment puts our patient back on track
Our patient was transferred to a tertiary care hospital for further management and consultation with endocrinology and neurosurgery. He was started on high-dose ketoconazole, an imidazole-derivative antifungal medication that acts to inhibit adrenal steroidogenesis and has been used successfully in patients with Cushing’s syndrome.^6,7 (Ketoconazole is typically dosed at 400-1200 mg/d⁷ and can be used for >6 months to 1 year, or temporarily in advance of surgery.)

Our patient underwent successful transsphenoidal adenectomy by neurosurgery, and his blood pressure, serum electrolytes, and serum glucose returned to normal levels. He is about to begin his senior year in high school.

CORRESPONDENCE Michael Barna, MD, Department of Family Medicine, Naval Hospital Camp Pendleton, Box 555191, Camp Pendleton, CA 92055; [email protected]

A review of the patient’s blood pressure since admission indicated consistently elevated systolic and diastolic pressures, on average, of 170/105 mm Hg. Additionally, his serum potassium levels ranged from 2.4 to 3.1 mmol/L (normal 3.5-5.1 mmol/L).

A detailed medical history and review of previous records revealed that an initial diagnosis of hypertension had been made during a routine sports physical at age 14, although the patient was cleared for full activity. Over the previous year, the patient said he had gained weight—much of it in the abdomen—and experienced sleep disturbances, increasing fatigability, muscle weakness, hair loss, and declining performance in his high school sports. In addition, he had noticed increased facial flushing and sweating.

On physical exam, we noted an obese male (height 5’5’’, weight 191.5 lb, BMI 30.86 kg/m²) with the following vital signs: temperature 97.9°F, pulse 105 bpm, and blood pressure 177/111 mm Hg. Pertinent physical exam findings outside of his surgical site included diffusely thinning hair, moon facies, facial plethora, increased supraclavicular and dorsocervical fat pads, thoracic and abdominal striae, thinned skin overlying his upper and lower extremities, and lower extremity edema ( FIGURE 1 ). All other exam findings were within normal limits.

Initial blood chemistry lab results revealed hyperglycemia (290 mg/dL; random normal, <200 mg/dL), hypokalemia (3.0 mmol/L; normal, 3.5-5.4 mmol/L), hypochloremia (96 mmol/L; normal, 98-107 mmol/L), and a mean corpuscular volume of 101.2 fL (normal, 80-100 fL). The patient also had a white blood cell (WBC) count of 14,400/mcL with a predominance of neutrophils and 6 bands, and a high sensitivity C-reactive protein level of 7.5 mg/dL (normal, <0.748 mg/dL).

FIGURE 1
The signs were all there

WHAT ADDITIONAL TESTING WOULD YOU ORDER?
WHAT IS YOUR PRESUMPTIVE DIAGNOSIS?

Suspecting Cushing’s syndrome, we ordered cortisol and ACTH

Based on our initial findings, we ordered a 24-hour urinary free cortisol and plasma adrenocorticotropic hormone (ACTH) level—both of which had to be sent to outside laboratories. We also ordered a computed tomography (CT) scan of the patient’s adrenal glands and magnetic resonance imaging (MRI) of his pituitary gland.

The CT scan revealed mild hyperplasia of the adrenal glands bilaterally; the MRI demonstrated a 7 × 6 × 6 mm pituitary microadenoma ( FIGURE 2 ) in the anterior portion of the gland. In addition, a 6 × 6 × 1 mm lesion was noted—thought to be a Rathke’s cleft (Pars intermedia) cyst by the reviewing radiologist.

The patient’s initial cortisol and ACTH lab work revealed a urinary cortisol level of 5089.2 mcg/24 h (normal, 3-55 mcg/24 h) and an ACTH level of 216 pg/mL (normal, 9-57 pg/mL for ages 3-17 years).

We diagnosed Cushing’s syndrome in this patient.

FIGURE 2
MRI reveals pituitary microadenoma

Differentiating between ACTH-dependent and -independent Cushing’s syndrome
Cushing’s syndrome is a constellation of signs and symptoms caused by an overproduction of cortisol, which results in a variety of abnormalities in the hypothalamic-pituitary-adrenal axis. In general, the syndrome is differentiated as either ACTH-dependent or ACTH-independent, based on the underlying cause.¹ Examples of ACTH-dependent Cushing’s syndrome include pituitary adenoma (formally classified as Cushing’s disease) and ectopic ACTH or corticotrophin-releasing hormone-producing tumors. Examples of ACTH-independent Cushing’s syndrome include adrenal adenoma or carcinoma and exogenous glucocorticoid therapy.²

Clinical manifestations include obesity, hypertension (usually with some degree of concurrent hypokalemia), skin abnormalities (eg, plethora, hirsutism, violaceous striae), musculoskeletal weakness, neuropsychiatric symptoms (eg, depression), gonadal dysfunction, and metabolic derangements, including glucose intolerance, diabetes, and hyperlipidemia. In children, a near universal decrease in linear growth secondary to hypercortisolism is seen.³

Investigating a suspected case of Cushing’s syndrome can be divided into 2 stages: confirming the diagnosis and establishing the etiology. The following tests can be used to make the diagnosis: 24-hour urinary free cortisol, low-dose dexamethasone suppression, and late-night salivary cortisol. Several of these tests require late-night administration that necessitates hospital admission. These tests are typically followed by a CT scan of the patient’s adrenal glands and/or an MRI of the patient’s pituitary gland to evaluate the etiology. Additionally, as demonstrated by the patient described here, ongoing issues with hypertension, metabolic abnormalities, and hyperglycemia may require intensive intervention and management.⁴

Don't be fooled
Potential complications in diagnosing the syndrome, however, can cloud an accurate diagnosis—especially early in the disease process. In addition to biochemical similarities between Cushing’s syndrome and obesity, depression, and alcoholism, ACTH-dependent Cushing’s syndrome can undergo cyclical or intermittent activity and can remain in remission for years.¹ Also, ectopic ACTH-secreting tumors may, by virtue of their small size and location, go undetected.

Don’t try to lower BP through usual means
Hypertension, a hallmark finding in approximately 80% of adults and 47% of children with Cushing’s syndrome,⁵ stems from hypercortisol-driven pathologic changes in the mechanisms controlling plasma volume, peripheral vascular resistance, and cardiac output. In addition, these cortisol-driven changes have a direct effect on mineralocorticoid and glucocorticoid receptors within the central nervous system. Secondary effects such as insulin resistance and the development of sleep apnea further complicate the management of this generally treatment-resistant hypertension. Lastly, specific mechanisms such as the cross-reactivity of excess glucocorticoids with mineralocorticoid receptors acting on targets within the kidney, can also lead to metabolic derangements, such as profound hypokalemia and metabolic alkalosis.

Thus, controlling hypertension and the metabolic changes seen in Cushing’s syndrome often requires addressing the underlying hypercortisolism rather than achieving normotension and normal serum electrolytes through the usual means.⁵

Treatment puts our patient back on track
Our patient was transferred to a tertiary care hospital for further management and consultation with endocrinology and neurosurgery. He was started on high-dose ketoconazole, an imidazole-derivative antifungal medication that acts to inhibit adrenal steroidogenesis and has been used successfully in patients with Cushing’s syndrome.^6,7 (Ketoconazole is typically dosed at 400-1200 mg/d⁷ and can be used for >6 months to 1 year, or temporarily in advance of surgery.)

Our patient underwent successful transsphenoidal adenectomy by neurosurgery, and his blood pressure, serum electrolytes, and serum glucose returned to normal levels. He is about to begin his senior year in high school.

CORRESPONDENCE Michael Barna, MD, Department of Family Medicine, Naval Hospital Camp Pendleton, Box 555191, Camp Pendleton, CA 92055; [email protected]

A review of the patient’s blood pressure since admission indicated consistently elevated systolic and diastolic pressures, on average, of 170/105 mm Hg. Additionally, his serum potassium levels ranged from 2.4 to 3.1 mmol/L (normal 3.5-5.1 mmol/L).

A detailed medical history and review of previous records revealed that an initial diagnosis of hypertension had been made during a routine sports physical at age 14, although the patient was cleared for full activity. Over the previous year, the patient said he had gained weight—much of it in the abdomen—and experienced sleep disturbances, increasing fatigability, muscle weakness, hair loss, and declining performance in his high school sports. In addition, he had noticed increased facial flushing and sweating.

On physical exam, we noted an obese male (height 5’5’’, weight 191.5 lb, BMI 30.86 kg/m²) with the following vital signs: temperature 97.9°F, pulse 105 bpm, and blood pressure 177/111 mm Hg. Pertinent physical exam findings outside of his surgical site included diffusely thinning hair, moon facies, facial plethora, increased supraclavicular and dorsocervical fat pads, thoracic and abdominal striae, thinned skin overlying his upper and lower extremities, and lower extremity edema ( FIGURE 1 ). All other exam findings were within normal limits.

Initial blood chemistry lab results revealed hyperglycemia (290 mg/dL; random normal, <200 mg/dL), hypokalemia (3.0 mmol/L; normal, 3.5-5.4 mmol/L), hypochloremia (96 mmol/L; normal, 98-107 mmol/L), and a mean corpuscular volume of 101.2 fL (normal, 80-100 fL). The patient also had a white blood cell (WBC) count of 14,400/mcL with a predominance of neutrophils and 6 bands, and a high sensitivity C-reactive protein level of 7.5 mg/dL (normal, <0.748 mg/dL).

FIGURE 1
The signs were all there

WHAT ADDITIONAL TESTING WOULD YOU ORDER?
WHAT IS YOUR PRESUMPTIVE DIAGNOSIS?

Suspecting Cushing’s syndrome, we ordered cortisol and ACTH

Based on our initial findings, we ordered a 24-hour urinary free cortisol and plasma adrenocorticotropic hormone (ACTH) level—both of which had to be sent to outside laboratories. We also ordered a computed tomography (CT) scan of the patient’s adrenal glands and magnetic resonance imaging (MRI) of his pituitary gland.

The CT scan revealed mild hyperplasia of the adrenal glands bilaterally; the MRI demonstrated a 7 × 6 × 6 mm pituitary microadenoma ( FIGURE 2 ) in the anterior portion of the gland. In addition, a 6 × 6 × 1 mm lesion was noted—thought to be a Rathke’s cleft (Pars intermedia) cyst by the reviewing radiologist.

The patient’s initial cortisol and ACTH lab work revealed a urinary cortisol level of 5089.2 mcg/24 h (normal, 3-55 mcg/24 h) and an ACTH level of 216 pg/mL (normal, 9-57 pg/mL for ages 3-17 years).

We diagnosed Cushing’s syndrome in this patient.

FIGURE 2
MRI reveals pituitary microadenoma

Differentiating between ACTH-dependent and -independent Cushing’s syndrome
Cushing’s syndrome is a constellation of signs and symptoms caused by an overproduction of cortisol, which results in a variety of abnormalities in the hypothalamic-pituitary-adrenal axis. In general, the syndrome is differentiated as either ACTH-dependent or ACTH-independent, based on the underlying cause.¹ Examples of ACTH-dependent Cushing’s syndrome include pituitary adenoma (formally classified as Cushing’s disease) and ectopic ACTH or corticotrophin-releasing hormone-producing tumors. Examples of ACTH-independent Cushing’s syndrome include adrenal adenoma or carcinoma and exogenous glucocorticoid therapy.²

Clinical manifestations include obesity, hypertension (usually with some degree of concurrent hypokalemia), skin abnormalities (eg, plethora, hirsutism, violaceous striae), musculoskeletal weakness, neuropsychiatric symptoms (eg, depression), gonadal dysfunction, and metabolic derangements, including glucose intolerance, diabetes, and hyperlipidemia. In children, a near universal decrease in linear growth secondary to hypercortisolism is seen.³

Investigating a suspected case of Cushing’s syndrome can be divided into 2 stages: confirming the diagnosis and establishing the etiology. The following tests can be used to make the diagnosis: 24-hour urinary free cortisol, low-dose dexamethasone suppression, and late-night salivary cortisol. Several of these tests require late-night administration that necessitates hospital admission. These tests are typically followed by a CT scan of the patient’s adrenal glands and/or an MRI of the patient’s pituitary gland to evaluate the etiology. Additionally, as demonstrated by the patient described here, ongoing issues with hypertension, metabolic abnormalities, and hyperglycemia may require intensive intervention and management.⁴

Don't be fooled
Potential complications in diagnosing the syndrome, however, can cloud an accurate diagnosis—especially early in the disease process. In addition to biochemical similarities between Cushing’s syndrome and obesity, depression, and alcoholism, ACTH-dependent Cushing’s syndrome can undergo cyclical or intermittent activity and can remain in remission for years.¹ Also, ectopic ACTH-secreting tumors may, by virtue of their small size and location, go undetected.

Don’t try to lower BP through usual means
Hypertension, a hallmark finding in approximately 80% of adults and 47% of children with Cushing’s syndrome,⁵ stems from hypercortisol-driven pathologic changes in the mechanisms controlling plasma volume, peripheral vascular resistance, and cardiac output. In addition, these cortisol-driven changes have a direct effect on mineralocorticoid and glucocorticoid receptors within the central nervous system. Secondary effects such as insulin resistance and the development of sleep apnea further complicate the management of this generally treatment-resistant hypertension. Lastly, specific mechanisms such as the cross-reactivity of excess glucocorticoids with mineralocorticoid receptors acting on targets within the kidney, can also lead to metabolic derangements, such as profound hypokalemia and metabolic alkalosis.

Thus, controlling hypertension and the metabolic changes seen in Cushing’s syndrome often requires addressing the underlying hypercortisolism rather than achieving normotension and normal serum electrolytes through the usual means.⁵

Treatment puts our patient back on track
Our patient was transferred to a tertiary care hospital for further management and consultation with endocrinology and neurosurgery. He was started on high-dose ketoconazole, an imidazole-derivative antifungal medication that acts to inhibit adrenal steroidogenesis and has been used successfully in patients with Cushing’s syndrome.^6,7 (Ketoconazole is typically dosed at 400-1200 mg/d⁷ and can be used for >6 months to 1 year, or temporarily in advance of surgery.)

Our patient underwent successful transsphenoidal adenectomy by neurosurgery, and his blood pressure, serum electrolytes, and serum glucose returned to normal levels. He is about to begin his senior year in high school.

CORRESPONDENCE Michael Barna, MD, Department of Family Medicine, Naval Hospital Camp Pendleton, Box 555191, Camp Pendleton, CA 92055; [email protected]

When assessing possible onychomycosis, conventional practice is to take samples from the most proximal infected area. But this approach is usually technically difficult and may cause discomfort to patients.^1-6 We therefore sought to determine the optimal location for fungal sampling from the distal part of the affected nail.

Methods

To assess the accuracy of distal sampling in diagnosing distal and lateral subungual onychomycosis (DLSO) of the toenails, we reevaluated 106 patients with DLSO previously confirmed by microscopic visualization of fungi in potassium hydroxide (KOH) solution and by fungal culture of specimens obtained using the proximal sampling approach.

Before we obtained our samples, we cleaned the nails with alcohol and pared the most distal part of the nails in an effort to eliminate contaminant molds and bacteria. Using a 1- or 2-mm curette, we took specimens first from the distal nail bed and, second, from the distal underside of the nail plate ( FIGURE ). We separated specimens for use in either direct KOH visualization or in fungal culture using Sabouraud’s Dextrose agar (Novamed; Jerusalem, Israel), which contains chloramphenicol or streptomycin and penicillin to prevent contamination.

FIGURE
Distal sampling for distal and lateral subungual onychomycosis

Statistical analyses
We recorded sociodemographic characteristics and fungal culture results in basic descriptive (prevalence) tables. In univariate analysis, we used t-tests to compare the means of continuous variables (eg, age, duration of fungal infection). To assess the distribution of categorical parameters (eg, sex) and to gauge the efficacy of the different probing techniques, we used chi-square (χ²) tests. We analyzed coded data using SPSS (Chicago, IL) for Windows software, version 12.

We conducted the study according to the rules of the local Helsinki Committee.

Results

We examined 106 patients with DLSO, of which 65 (61.3%) were male and 41 (38.7%) were female, ages 23 to 72 years (mean age, 44.6). The duration of fungal infection ranged from 3 to 30 years, with a mean of 14.9 years. In 70.8% of cases, the infection involved the first toenail. Duration of the fungal disease did not differ significantly between the sexes.

KOH test results were positive for 84 (79.2%) specimens from the distal nail bed, and for only 60 (56.6%) specimens from the distal underside of the nail plate (P=.0007); culture results were positive for 93 (87.7%) and 76 (71.7%) specimens, respectively (P=.0063). Combining results from both locations (all positive samples from the nail bed, plus positive samples from the nail underside when results from the nail bed were negative) yielded confirmation with KOH testing in 92 (86.8%) patients and with culture in 100 (94.3%) patients. There were no statistically significant differences between the combined results of both locations and the results from the distal nail bed alone (KOH, P=.143; culture, P=.149) ( TABLE ).

TABLE
Accuracy of distal sampling in 106 patients with confirmed DLSO

Discussion

In DLSO, most dermatophyte species invade the middle and ventral layers of the nail plate adjacent to the nail bed, where the keratin is soft and close to the living cells below. In fact, the nail bed is probably the primary invasion site of dermatophytes, and it acts as a reservoir for continual reinfection of the growing nail.⁷ Obtaining confirmation of fungal infection before initiating antifungal treatment is the gold standard in clinical practice, given that antifungal agents have potentially serious adverse effects, that treatment is expensive, and that medicolegal issues exist.⁸

The standard methods used to detect a fungal nail infection are direct microscopy with KOH preparation and fungal culture. The KOH test is the simplest, least expensive method used in the detection of fungi, but it cannot identify the specific pathogen. Fungal speciation is done by culture. More accurate histopathologic evaluation is possible with periodic acid-Schiff stain, immunofluorescent microscopy with calcofluor stain, or polymerase chain reaction, but these techniques are more expensive and less feasible in outpatient clinics.⁹

The diagnostic accuracy of the KOH test and fungal culture ranges from 50% to 70%, depending on the experience of the laboratory technician and the methods used to collect and prepare the sample.^8-10 It is better to take samples from the most proximal infected area by curettage or drilling, but this technique is usually more difficult than a distal approach, should be performed by skilled personnel, and may cause discomfort to patients.^3,5,6

Our recommendation for practice. Earlier studies suggested that nail specimens should be taken from the nail bed.^11-13 We sampled the nail bed first in our study because, in trying to determine an optimal location for sampling, we wanted to avoid contaminating nail-bed specimens with debris from the underside of the nail. In practice, however, we suggest that, in cases of suspected DLSO, clinicians first obtain specimens from the distal underside of the nail, and then collect all remaining material from the distal part of the nail bed. This technique is simple and can easily be performed in an office setting. If test results are negative but DLSO remains clinically likely, test a second sample after a week or 2.

CORRESPONDENCE Boaz Amichai, MD, Department of Dermatology, Sheba Medical Center, Tel-Hashomer, Israel; [email protected]

When assessing possible onychomycosis, conventional practice is to take samples from the most proximal infected area. But this approach is usually technically difficult and may cause discomfort to patients.^1-6 We therefore sought to determine the optimal location for fungal sampling from the distal part of the affected nail.

Methods

To assess the accuracy of distal sampling in diagnosing distal and lateral subungual onychomycosis (DLSO) of the toenails, we reevaluated 106 patients with DLSO previously confirmed by microscopic visualization of fungi in potassium hydroxide (KOH) solution and by fungal culture of specimens obtained using the proximal sampling approach.

Before we obtained our samples, we cleaned the nails with alcohol and pared the most distal part of the nails in an effort to eliminate contaminant molds and bacteria. Using a 1- or 2-mm curette, we took specimens first from the distal nail bed and, second, from the distal underside of the nail plate ( FIGURE ). We separated specimens for use in either direct KOH visualization or in fungal culture using Sabouraud’s Dextrose agar (Novamed; Jerusalem, Israel), which contains chloramphenicol or streptomycin and penicillin to prevent contamination.

FIGURE
Distal sampling for distal and lateral subungual onychomycosis

Statistical analyses
We recorded sociodemographic characteristics and fungal culture results in basic descriptive (prevalence) tables. In univariate analysis, we used t-tests to compare the means of continuous variables (eg, age, duration of fungal infection). To assess the distribution of categorical parameters (eg, sex) and to gauge the efficacy of the different probing techniques, we used chi-square (χ²) tests. We analyzed coded data using SPSS (Chicago, IL) for Windows software, version 12.

We conducted the study according to the rules of the local Helsinki Committee.

Results

We examined 106 patients with DLSO, of which 65 (61.3%) were male and 41 (38.7%) were female, ages 23 to 72 years (mean age, 44.6). The duration of fungal infection ranged from 3 to 30 years, with a mean of 14.9 years. In 70.8% of cases, the infection involved the first toenail. Duration of the fungal disease did not differ significantly between the sexes.

KOH test results were positive for 84 (79.2%) specimens from the distal nail bed, and for only 60 (56.6%) specimens from the distal underside of the nail plate (P=.0007); culture results were positive for 93 (87.7%) and 76 (71.7%) specimens, respectively (P=.0063). Combining results from both locations (all positive samples from the nail bed, plus positive samples from the nail underside when results from the nail bed were negative) yielded confirmation with KOH testing in 92 (86.8%) patients and with culture in 100 (94.3%) patients. There were no statistically significant differences between the combined results of both locations and the results from the distal nail bed alone (KOH, P=.143; culture, P=.149) ( TABLE ).

TABLE
Accuracy of distal sampling in 106 patients with confirmed DLSO

Discussion

In DLSO, most dermatophyte species invade the middle and ventral layers of the nail plate adjacent to the nail bed, where the keratin is soft and close to the living cells below. In fact, the nail bed is probably the primary invasion site of dermatophytes, and it acts as a reservoir for continual reinfection of the growing nail.⁷ Obtaining confirmation of fungal infection before initiating antifungal treatment is the gold standard in clinical practice, given that antifungal agents have potentially serious adverse effects, that treatment is expensive, and that medicolegal issues exist.⁸

The standard methods used to detect a fungal nail infection are direct microscopy with KOH preparation and fungal culture. The KOH test is the simplest, least expensive method used in the detection of fungi, but it cannot identify the specific pathogen. Fungal speciation is done by culture. More accurate histopathologic evaluation is possible with periodic acid-Schiff stain, immunofluorescent microscopy with calcofluor stain, or polymerase chain reaction, but these techniques are more expensive and less feasible in outpatient clinics.⁹

The diagnostic accuracy of the KOH test and fungal culture ranges from 50% to 70%, depending on the experience of the laboratory technician and the methods used to collect and prepare the sample.^8-10 It is better to take samples from the most proximal infected area by curettage or drilling, but this technique is usually more difficult than a distal approach, should be performed by skilled personnel, and may cause discomfort to patients.^3,5,6

Our recommendation for practice. Earlier studies suggested that nail specimens should be taken from the nail bed.^11-13 We sampled the nail bed first in our study because, in trying to determine an optimal location for sampling, we wanted to avoid contaminating nail-bed specimens with debris from the underside of the nail. In practice, however, we suggest that, in cases of suspected DLSO, clinicians first obtain specimens from the distal underside of the nail, and then collect all remaining material from the distal part of the nail bed. This technique is simple and can easily be performed in an office setting. If test results are negative but DLSO remains clinically likely, test a second sample after a week or 2.

CORRESPONDENCE Boaz Amichai, MD, Department of Dermatology, Sheba Medical Center, Tel-Hashomer, Israel; [email protected]

When assessing possible onychomycosis, conventional practice is to take samples from the most proximal infected area. But this approach is usually technically difficult and may cause discomfort to patients.^1-6 We therefore sought to determine the optimal location for fungal sampling from the distal part of the affected nail.

Methods

To assess the accuracy of distal sampling in diagnosing distal and lateral subungual onychomycosis (DLSO) of the toenails, we reevaluated 106 patients with DLSO previously confirmed by microscopic visualization of fungi in potassium hydroxide (KOH) solution and by fungal culture of specimens obtained using the proximal sampling approach.

Before we obtained our samples, we cleaned the nails with alcohol and pared the most distal part of the nails in an effort to eliminate contaminant molds and bacteria. Using a 1- or 2-mm curette, we took specimens first from the distal nail bed and, second, from the distal underside of the nail plate ( FIGURE ). We separated specimens for use in either direct KOH visualization or in fungal culture using Sabouraud’s Dextrose agar (Novamed; Jerusalem, Israel), which contains chloramphenicol or streptomycin and penicillin to prevent contamination.

FIGURE
Distal sampling for distal and lateral subungual onychomycosis

Statistical analyses
We recorded sociodemographic characteristics and fungal culture results in basic descriptive (prevalence) tables. In univariate analysis, we used t-tests to compare the means of continuous variables (eg, age, duration of fungal infection). To assess the distribution of categorical parameters (eg, sex) and to gauge the efficacy of the different probing techniques, we used chi-square (χ²) tests. We analyzed coded data using SPSS (Chicago, IL) for Windows software, version 12.

We conducted the study according to the rules of the local Helsinki Committee.

Results

We examined 106 patients with DLSO, of which 65 (61.3%) were male and 41 (38.7%) were female, ages 23 to 72 years (mean age, 44.6). The duration of fungal infection ranged from 3 to 30 years, with a mean of 14.9 years. In 70.8% of cases, the infection involved the first toenail. Duration of the fungal disease did not differ significantly between the sexes.

KOH test results were positive for 84 (79.2%) specimens from the distal nail bed, and for only 60 (56.6%) specimens from the distal underside of the nail plate (P=.0007); culture results were positive for 93 (87.7%) and 76 (71.7%) specimens, respectively (P=.0063). Combining results from both locations (all positive samples from the nail bed, plus positive samples from the nail underside when results from the nail bed were negative) yielded confirmation with KOH testing in 92 (86.8%) patients and with culture in 100 (94.3%) patients. There were no statistically significant differences between the combined results of both locations and the results from the distal nail bed alone (KOH, P=.143; culture, P=.149) ( TABLE ).

TABLE
Accuracy of distal sampling in 106 patients with confirmed DLSO

Discussion

In DLSO, most dermatophyte species invade the middle and ventral layers of the nail plate adjacent to the nail bed, where the keratin is soft and close to the living cells below. In fact, the nail bed is probably the primary invasion site of dermatophytes, and it acts as a reservoir for continual reinfection of the growing nail.⁷ Obtaining confirmation of fungal infection before initiating antifungal treatment is the gold standard in clinical practice, given that antifungal agents have potentially serious adverse effects, that treatment is expensive, and that medicolegal issues exist.⁸

The standard methods used to detect a fungal nail infection are direct microscopy with KOH preparation and fungal culture. The KOH test is the simplest, least expensive method used in the detection of fungi, but it cannot identify the specific pathogen. Fungal speciation is done by culture. More accurate histopathologic evaluation is possible with periodic acid-Schiff stain, immunofluorescent microscopy with calcofluor stain, or polymerase chain reaction, but these techniques are more expensive and less feasible in outpatient clinics.⁹

The diagnostic accuracy of the KOH test and fungal culture ranges from 50% to 70%, depending on the experience of the laboratory technician and the methods used to collect and prepare the sample.^8-10 It is better to take samples from the most proximal infected area by curettage or drilling, but this technique is usually more difficult than a distal approach, should be performed by skilled personnel, and may cause discomfort to patients.^3,5,6

Our recommendation for practice. Earlier studies suggested that nail specimens should be taken from the nail bed.^11-13 We sampled the nail bed first in our study because, in trying to determine an optimal location for sampling, we wanted to avoid contaminating nail-bed specimens with debris from the underside of the nail. In practice, however, we suggest that, in cases of suspected DLSO, clinicians first obtain specimens from the distal underside of the nail, and then collect all remaining material from the distal part of the nail bed. This technique is simple and can easily be performed in an office setting. If test results are negative but DLSO remains clinically likely, test a second sample after a week or 2.

CORRESPONDENCE Boaz Amichai, MD, Department of Dermatology, Sheba Medical Center, Tel-Hashomer, Israel; [email protected]

Cardiovascular disease (CVD) is the principal cause of death in the United States.¹ As the population grows older and obesity and diabetes become increasingly prevalent, the prevalence of CVD is also expected to rise.^2,3 Fortunately, many CVD events can be prevented or delayed by modifying risk factors such as hyperlipidemia, hypertension, and smoking. Interventions associated with a reduction in risk have led to a reduction in CVD events^4,5 and contributed to a steady decline in cardiac deaths.⁶

Control of platelet aggregation is a cornerstone of primary CVD prevention.⁷ In an outpatient setting, this usually translates into identifying patients who are at high risk for a CVD event and advising them to take low-dose aspirin daily or every other day. Although not without controversy,^8,9 the US Preventive Services Task Force (USPSTF) recommends regular aspirin use for primary CVD prevention for middle-aged to older men at high risk for myocardial infarction (MI) and women at high risk for ischemic stroke.¹⁰

The efficacy of this intervention is proven: In primary prevention trials, regular aspirin use is associated with a 14% reduction in the likelihood of CVD events over 7 years.¹¹ What’s more, aspirin therapy, as recommended by the USPSTF, is among the most cost-effective clinic-based preventive measures.¹²

In 2004, 41% of US adults age 40 or older reported taking aspirin regularly¹³ —an increase of approximately 20% since 1999.¹⁴ More recent data from a national population-based cohort study found that 41% of adults ages 45 to 90 years who did not have CVD but were at moderate to high risk for a CVD event reported taking aspirin ≥3 days per week.¹⁵ In the same study, almost one-fourth of those at low CVD risk also reported regular aspirin use.

While regular aspirin use for primary CVD prevention has been on the rise,^13,14 the extent to which this intervention has penetrated various segments of the population is unclear. Several studies have found that aspirin use is consistently highest among those who are older, male, and white.^15-17 Other socioeconomic variables (eg, education level, employment, marital status) have received little attention. And no previous study has used national guidelines for aspirin therapy to stratify samples.

A look at overuse and underuse. To ensure that aspirin therapy for primary CVD prevention is directed at those who are most likely to benefit from it, a better understanding of variables associated with both aspirin overuse and underuse is needed. This area of research is important, in part because direct-to-consumer aspirin marketing may be particularly influential among groups at low risk for CVD—for whom the risk of excess bleeding outweighs the potential for disease prevention.^13,18

This study was undertaken to examine the association between specific sociodemographic variables and aspirin use among a representative sample of Wisconsin adults without CVD, looking both at those for whom aspirin therapy is indicated and those for whom it is not indicated based on national guidelines.

Methods

Design
We used a cross-sectional design, with data from the Survey of the Health of Wisconsin (SHOW),¹⁹ an annual survey of Wisconsin residents ages 21 to 74 years. SHOW uses a 2-stage stratified cluster sampling design to select households, with all age-eligible household members invited to participate. Recruitment for the annual survey consists of general community-wide announcements, as well as an initial letter and up to 6 visits to the randomly selected households to encourage participation.

By the end of 2010, SHOW had 1572 enrollees—about 53% of all eligible invitees. The demographic profile of SHOW enrollees was similar to US census data for all Wisconsin adults during the same time frame.¹⁹ All SHOW procedures were approved by the University of Wisconsin Institutional Review Board, and all participants provided informed consent.

Study sample
Our analyses were based on data provided by SHOW participants who were screened and enrolled between 2008 and 2010. To be included in our study, participants had to be between the ages of 35 and 74 years; not pregnant, on active military duty, or institutionalized; and have no personal history of CVD (myocardial infarction, angina, stroke, or transient ischemic attack) or CVD risk equivalent (type 1 or type 2 diabetes) at the time of recruitment. Data on key study variables had to be available, as well. (We used 35 years as the lower age limit because of the very low likelihood of CVD in younger individuals.)

We stratified the analytical sample (N=831) into 2 groups—participants for whom aspirin therapy was indicated and those for whom it was not indicated—in order to examine aspirin’s appropriate (recommended) and inappropriate use.

Measures
Outcome. The outcome variable was aspirin use. SHOW had asked participants how often they took aspirin. Similar to the methods used by Sanchez et al,¹⁵ we classified those who reported taking aspirin most (≥4) days of the week as regular aspirin users. All others were classified as nonregular aspirin users. Participants were not asked about the daily dose or weekly volume of aspirin.

Variables
Sociodemographic variables considered in our analysis were age, sex, race/ethnicity, education level, marital/partner status, employment status, health insurance, and region of residence within Wisconsin.

All participants underwent physical examinations, conducted as part of SHOW, at either a permanent or mobile exam center. Blood pressure was measured after a 5-minute rest period in a seated position, and the average of the last 2 out of 3 consecutive measurements was reported. Body mass index (BMI) was calculated, and blood samples were obtained by venipuncture, processed immediately, and sent to the Marshfield Clinic laboratory for measuring total and high-density lipoprotein (HDL) cholesterol.

Indications for aspirin therapy. We stratified the sample by those who were and those who were not candidates for aspirin therapy for primary CVD prevention based on the latest guidelines from the USPSTF ( FIGURE ).¹⁰ The Task Force recommends aspirin therapy for men ages 45 to 74 years with a moderate or greater 10-year risk of a coronary heart disease (CHD) event and women ages 55 to 74 years with a moderate or greater 10-year risk of stroke. We used the global CVD risk equation derived from the Framingham Heart Study (based on age, sex, smoking status, systolic blood pressure, and total and HDL cholesterol) to calculate each participant’s 10-year risk and, thus, determine whether aspirin therapy was or was not indicated.²⁰ Total and HDL cholesterol values were missing for 94 participants in the analytical sample; their 10-year CVD risk was estimated using BMI, a reasonable alternative to more conventional CVD risk prediction when laboratory values are unavailable.²¹

FIGURE
Study (SHOW) sample, stratified based on aspirin indication¹⁰

Statistical analyses
All analytical procedures were conducted using Statistical Analysis Software (SAS Version 9.2; Cary, NC). A complete-case framework was used.

We used multivariate logistic regression for survey data (PROC SURVEYLOGISTIC; SAS Institute, Cary, NC) to examine the association between aspirin use and sociodemographic variables. Two separate analyses were conducted, one of participants for whom aspirin therapy was indicated and the other for participants for whom it was not. The outcomes were modeled dichotomously, as regular vs nonregular aspirin users, and a collinearity check was done. ²¹

Initially, we created univariate models to gauge the crude relationship between each variable and aspirin use. Any variable with P<.20 in its univariate association with regular aspirin use was considered for inclusion in the final multivariate regression model. In the multivariate analyses, we sequentially eliminated variables with the weakest association with aspirin use until only significant (P<.10) independent predictors remained. Appropriate weighting was applied based on survey strata and cluster structure.¹⁹

Results

Of the 831 participants who met the eligibility criteria for our analysis, 268 (32%) had an aspirin indication. TABLE 1 shows the key characteristics of the analytical sample, stratified by those for whom aspirin was indicated and those for whom it was not. The sample was primarily middle-aged (mean age 52.4±0.36) and non-Hispanic white (93%). Compared with those for whom aspirin therapy was not indicated, the group with an aspirin indication was significantly older (56.9 vs 50.3) and had a significantly higher proportion of males (97% vs 19%). As expected, those for whom aspirin was indicated were also at higher risk for CHD and stroke, most notably as a result of significantly higher systolic BP (131.9 vs 121.5 mm Hg) and lower HDL cholesterol (42.5 vs 52.6 mg/dL) compared with participants without an aspirin indication.

TABLE 1
Study sample, by sociodemographic variable and aspirin indication

When aspirin was indicated, use was linked to age and sex
In the group with an aspirin indication (n=268), 83 (31%) reported taking aspirin most days of the week. The initial examination of sociodemographic variables showed that age, sex, and employment status demonstrated significant univariate associations with regular aspirin use ( TABLE 2 ). In the multivariate model, however, the odds of regular aspirin use were significantly greater among participants who were older (odds ratio [OR], 1.07; P<.001) or female (OR, 3.49; P=.021) compared with participants who were younger or male, respectively.

TABLE 2
Participants who have an aspirin indication: Association between sociodemographic variables and regular aspirin use

When aspirin was not indicated, age and sex still affected use
Among the 563 participants for whom aspirin therapy was not indicated, 102 (18%) reported taking aspirin regularly. Age, sex, race/ethnicity, health insurance, and employment ( TABLE 3 ), as well as region of residence and study enrollment year, had significant univariate associations with regular aspirin use; these variables were tested for potential inclusion in the multivariate model. In the final multivariate regression model, the odds of regular aspirin use were significantly greater among participants who were older (OR, 1.07; P<.001) and significantly lower among participants who were Hispanic or nonwhite (OR, 0.32; P=.063).

TABLE 3
Participants who do not have an aspirin indication: Association between sociodemographic variables and regular aspirin use

Discussion

Aspirin was generally underutilized in the group with significant CVD risk (n=268) in our study, with slightly less than a third of participants for whom aspirin therapy was indicated taking it most days of the week. Despite trends of increased aspirin use among US adults in recent years,¹⁵ aspirin therapy in the 2008-2010 SHOW sample was lower than in 2005 to 2008. It was also lower than national estimates of aspirin use for primary CVD prevention^15,22 —but about 20% higher than estimates of overall aspirin use in Wisconsin 20 years ago.²³ Consistent with previous research, the final adjusted model and sensitivity analysis indicated that older individuals were more likely to take aspirin regularly.

Contrary to the findings in some previous studies,^15-17 however, our analysis suggested that women had a higher adjusted odds of regular aspirin use compared with men. This result should be interpreted with extreme caution, however, because so few females (9 of 464 [3%]) met the current USPSTF criteria for aspirin therapy for primary CVD prevention. The previous USPSTF guidelines^24,25 were less conservative, with a lower minimum age and threshold for CVD risk for women. The revision is the likely result of recent primary prevention trials¹⁰ that found regular aspirin use provided less cardioprotection for younger women.

The sample without an aspirin indication—roughly twice the size of the group with an aspirin indication (563 vs 268), which is reflective of the general population of Wisconsin—was useful in highlighting inappropriate use. There were clear indications of aspirin overuse in this group, with 18% of the sample reporting that they took aspirin regularly. The finding that inappropriate aspirin use was more likely in non-Hispanic whites vs minorities is similar to the result of an earlier study in which blacks, Hispanics, and Chinese Americans with low CVD risk were much less likely to report regular aspirin use compared with whites at low risk.¹⁵

The main concern with regular aspirin use in those for whom it is not indicated for primary CVD prevention is the risk of upper gastrointestinal bleeding and, less commonly, hemorrhagic stroke.²⁶ To illustrate this point, consider the following: About 10% of SHOW participants ages 35 to 74 years had no history of CVD and no indication for aspirin therapy based on the latest USPSTF guidelines, but took aspirin regularly nonetheless. Extrapolating those numbers to the entire state of Wisconsin would suggest that approximately 270,000 state residents have a similar profile. Assuming an extra 1.3 major bleeding events per 1000 person-years of regular aspirin use (as a meta-analysis of studies of adverse events associated with antiplatelet therapy found),²⁷ that would translate into an estimated 350 major bleeding events per year in Wisconsin that are attributable to aspirin overuse.

In view of the current USPSTF recommendations,¹⁰ aspirin is not optimally utilized by Wisconsin residents for the primary prevention of CVD. Aspirin therapy is not used enough by those with a high CVD risk, who could derive substantial vascular disease protection from it. Conversely, aspirin therapy is overused by those with a low CVD risk, for whom the risk of major bleeding is significantly higher than the potential for vascular disease protection. Furthermore, younger individuals at high CVD risk appear to be least likely to take aspirin regularly.

Recommendations
The strongest modifiable predictor of regular aspirin use is a recommendation from a clinician.¹³ Therefore, we recommend stronger primary care initiatives to ensure that patients are screened for aspirin use more frequently, particularly middle-aged men at high CVD risk. This clinic-based initiative could reach a larger proportion of the general population when combined with broader, community-oriented CVD preventive services.²⁸

More precise marketing and education are also needed. Because aspirin is a low-cost over-the-counter product that leads the consumer market for analgesics,²⁹ the general public (and older, non-Hispanic whites, in particular) needs to be better informed about the risks of medically inappropriate aspirin use for primary CVD prevention.

Study limitations
Selection and measurement biases were among the chief study limitations.

Study (SHOW) enrollment rate was slightly above 50%, with steady increases in enrollment each year (from 46% in 2008-2009 to 56% in 2010) due to expanded recruitment and consolidation of field operations.

Aspirin use was self-reported, and SHOW did not capture the reason for taking it (eg, CVD prevention or pain management). Some evidence of overreporting of aspirin use among older individuals exists,³⁰ suggesting that a more objective measure of aspirin use (eg, pill bottle verification or blood platelet aggregation test) could yield different results.

Certain confounders were not measured, most notably contraindications to aspirin (eg, genetic platelet abnormalities). Such findings could explain some patterns of aspirin use in both strata, as up to 10% of any given population has a contraindication to aspirin due to allergy, intolerance, gastrointestinal ulcer, concomitant anticoagulant medication, or other high bleeding risk.^18,31 Few of these variables were known about our sample.

TABLE 4W (available below) provides a breakdown of some possible aspirin contraindications, as well as possible reasons other than primary CVD prevention for regular aspirin use. Because clinical judgment is often required to assess the degree of severity of a given health condition in order to deem it an aspirin contraindication, these findings could not reliably be used to reclassify participants. We present them simply for hypothesis generation.

Some data collection predates the current USPSTF guidelines,¹⁰ which could have resulted in a misclassification of participants’ aspirin indication. However, sensitivity analyses restricted to the 2010 sample alone—the only one with data collection after the newer guidelines were released—did not reveal any meaningful differences.

Other methodological limitations include the less racially diverse population of Wisconsin compared with other parts of the country and the sample size, which did not permit testing for statistical interactions and perhaps resulted in larger confidence intervals for some associations (eg, race/ethnicity) relative to the population as a whole.

TABLE 4W
Possible reasons for aspirin use—or contraindication— by aspirin indication*

Acknowledgement

The authors thank Matt Walsh, PhD, for his assistance in creating the analytical dataset, as well as Sally Steward-Townsend, Susan Wright, Bri Deyo, Bethany Varley, and the rest of the Survey of the Health of Wisconsin staff.

CORRESPONDENCE Jeffrey J. VanWormer, PhD, Epidemiology Research Center, Marshfield Clinic Research Foundation, 1000 North Oak Avenue, Marshfield, WI 54449; [email protected]

Cardiovascular disease (CVD) is the principal cause of death in the United States.¹ As the population grows older and obesity and diabetes become increasingly prevalent, the prevalence of CVD is also expected to rise.^2,3 Fortunately, many CVD events can be prevented or delayed by modifying risk factors such as hyperlipidemia, hypertension, and smoking. Interventions associated with a reduction in risk have led to a reduction in CVD events^4,5 and contributed to a steady decline in cardiac deaths.⁶

Control of platelet aggregation is a cornerstone of primary CVD prevention.⁷ In an outpatient setting, this usually translates into identifying patients who are at high risk for a CVD event and advising them to take low-dose aspirin daily or every other day. Although not without controversy,^8,9 the US Preventive Services Task Force (USPSTF) recommends regular aspirin use for primary CVD prevention for middle-aged to older men at high risk for myocardial infarction (MI) and women at high risk for ischemic stroke.¹⁰

The efficacy of this intervention is proven: In primary prevention trials, regular aspirin use is associated with a 14% reduction in the likelihood of CVD events over 7 years.¹¹ What’s more, aspirin therapy, as recommended by the USPSTF, is among the most cost-effective clinic-based preventive measures.¹²

In 2004, 41% of US adults age 40 or older reported taking aspirin regularly¹³ —an increase of approximately 20% since 1999.¹⁴ More recent data from a national population-based cohort study found that 41% of adults ages 45 to 90 years who did not have CVD but were at moderate to high risk for a CVD event reported taking aspirin ≥3 days per week.¹⁵ In the same study, almost one-fourth of those at low CVD risk also reported regular aspirin use.

While regular aspirin use for primary CVD prevention has been on the rise,^13,14 the extent to which this intervention has penetrated various segments of the population is unclear. Several studies have found that aspirin use is consistently highest among those who are older, male, and white.^15-17 Other socioeconomic variables (eg, education level, employment, marital status) have received little attention. And no previous study has used national guidelines for aspirin therapy to stratify samples.

A look at overuse and underuse. To ensure that aspirin therapy for primary CVD prevention is directed at those who are most likely to benefit from it, a better understanding of variables associated with both aspirin overuse and underuse is needed. This area of research is important, in part because direct-to-consumer aspirin marketing may be particularly influential among groups at low risk for CVD—for whom the risk of excess bleeding outweighs the potential for disease prevention.^13,18

This study was undertaken to examine the association between specific sociodemographic variables and aspirin use among a representative sample of Wisconsin adults without CVD, looking both at those for whom aspirin therapy is indicated and those for whom it is not indicated based on national guidelines.

Methods

Design
We used a cross-sectional design, with data from the Survey of the Health of Wisconsin (SHOW),¹⁹ an annual survey of Wisconsin residents ages 21 to 74 years. SHOW uses a 2-stage stratified cluster sampling design to select households, with all age-eligible household members invited to participate. Recruitment for the annual survey consists of general community-wide announcements, as well as an initial letter and up to 6 visits to the randomly selected households to encourage participation.

By the end of 2010, SHOW had 1572 enrollees—about 53% of all eligible invitees. The demographic profile of SHOW enrollees was similar to US census data for all Wisconsin adults during the same time frame.¹⁹ All SHOW procedures were approved by the University of Wisconsin Institutional Review Board, and all participants provided informed consent.

Study sample
Our analyses were based on data provided by SHOW participants who were screened and enrolled between 2008 and 2010. To be included in our study, participants had to be between the ages of 35 and 74 years; not pregnant, on active military duty, or institutionalized; and have no personal history of CVD (myocardial infarction, angina, stroke, or transient ischemic attack) or CVD risk equivalent (type 1 or type 2 diabetes) at the time of recruitment. Data on key study variables had to be available, as well. (We used 35 years as the lower age limit because of the very low likelihood of CVD in younger individuals.)

We stratified the analytical sample (N=831) into 2 groups—participants for whom aspirin therapy was indicated and those for whom it was not indicated—in order to examine aspirin’s appropriate (recommended) and inappropriate use.

Measures
Outcome. The outcome variable was aspirin use. SHOW had asked participants how often they took aspirin. Similar to the methods used by Sanchez et al,¹⁵ we classified those who reported taking aspirin most (≥4) days of the week as regular aspirin users. All others were classified as nonregular aspirin users. Participants were not asked about the daily dose or weekly volume of aspirin.

Variables
Sociodemographic variables considered in our analysis were age, sex, race/ethnicity, education level, marital/partner status, employment status, health insurance, and region of residence within Wisconsin.

All participants underwent physical examinations, conducted as part of SHOW, at either a permanent or mobile exam center. Blood pressure was measured after a 5-minute rest period in a seated position, and the average of the last 2 out of 3 consecutive measurements was reported. Body mass index (BMI) was calculated, and blood samples were obtained by venipuncture, processed immediately, and sent to the Marshfield Clinic laboratory for measuring total and high-density lipoprotein (HDL) cholesterol.

Indications for aspirin therapy. We stratified the sample by those who were and those who were not candidates for aspirin therapy for primary CVD prevention based on the latest guidelines from the USPSTF ( FIGURE ).¹⁰ The Task Force recommends aspirin therapy for men ages 45 to 74 years with a moderate or greater 10-year risk of a coronary heart disease (CHD) event and women ages 55 to 74 years with a moderate or greater 10-year risk of stroke. We used the global CVD risk equation derived from the Framingham Heart Study (based on age, sex, smoking status, systolic blood pressure, and total and HDL cholesterol) to calculate each participant’s 10-year risk and, thus, determine whether aspirin therapy was or was not indicated.²⁰ Total and HDL cholesterol values were missing for 94 participants in the analytical sample; their 10-year CVD risk was estimated using BMI, a reasonable alternative to more conventional CVD risk prediction when laboratory values are unavailable.²¹

FIGURE
Study (SHOW) sample, stratified based on aspirin indication¹⁰

Statistical analyses
All analytical procedures were conducted using Statistical Analysis Software (SAS Version 9.2; Cary, NC). A complete-case framework was used.

We used multivariate logistic regression for survey data (PROC SURVEYLOGISTIC; SAS Institute, Cary, NC) to examine the association between aspirin use and sociodemographic variables. Two separate analyses were conducted, one of participants for whom aspirin therapy was indicated and the other for participants for whom it was not. The outcomes were modeled dichotomously, as regular vs nonregular aspirin users, and a collinearity check was done. ²¹

Initially, we created univariate models to gauge the crude relationship between each variable and aspirin use. Any variable with P<.20 in its univariate association with regular aspirin use was considered for inclusion in the final multivariate regression model. In the multivariate analyses, we sequentially eliminated variables with the weakest association with aspirin use until only significant (P<.10) independent predictors remained. Appropriate weighting was applied based on survey strata and cluster structure.¹⁹

Results

Of the 831 participants who met the eligibility criteria for our analysis, 268 (32%) had an aspirin indication. TABLE 1 shows the key characteristics of the analytical sample, stratified by those for whom aspirin was indicated and those for whom it was not. The sample was primarily middle-aged (mean age 52.4±0.36) and non-Hispanic white (93%). Compared with those for whom aspirin therapy was not indicated, the group with an aspirin indication was significantly older (56.9 vs 50.3) and had a significantly higher proportion of males (97% vs 19%). As expected, those for whom aspirin was indicated were also at higher risk for CHD and stroke, most notably as a result of significantly higher systolic BP (131.9 vs 121.5 mm Hg) and lower HDL cholesterol (42.5 vs 52.6 mg/dL) compared with participants without an aspirin indication.

TABLE 1
Study sample, by sociodemographic variable and aspirin indication

When aspirin was indicated, use was linked to age and sex
In the group with an aspirin indication (n=268), 83 (31%) reported taking aspirin most days of the week. The initial examination of sociodemographic variables showed that age, sex, and employment status demonstrated significant univariate associations with regular aspirin use ( TABLE 2 ). In the multivariate model, however, the odds of regular aspirin use were significantly greater among participants who were older (odds ratio [OR], 1.07; P<.001) or female (OR, 3.49; P=.021) compared with participants who were younger or male, respectively.

TABLE 2
Participants who have an aspirin indication: Association between sociodemographic variables and regular aspirin use

When aspirin was not indicated, age and sex still affected use
Among the 563 participants for whom aspirin therapy was not indicated, 102 (18%) reported taking aspirin regularly. Age, sex, race/ethnicity, health insurance, and employment ( TABLE 3 ), as well as region of residence and study enrollment year, had significant univariate associations with regular aspirin use; these variables were tested for potential inclusion in the multivariate model. In the final multivariate regression model, the odds of regular aspirin use were significantly greater among participants who were older (OR, 1.07; P<.001) and significantly lower among participants who were Hispanic or nonwhite (OR, 0.32; P=.063).

TABLE 3
Participants who do not have an aspirin indication: Association between sociodemographic variables and regular aspirin use

Discussion

Aspirin was generally underutilized in the group with significant CVD risk (n=268) in our study, with slightly less than a third of participants for whom aspirin therapy was indicated taking it most days of the week. Despite trends of increased aspirin use among US adults in recent years,¹⁵ aspirin therapy in the 2008-2010 SHOW sample was lower than in 2005 to 2008. It was also lower than national estimates of aspirin use for primary CVD prevention^15,22 —but about 20% higher than estimates of overall aspirin use in Wisconsin 20 years ago.²³ Consistent with previous research, the final adjusted model and sensitivity analysis indicated that older individuals were more likely to take aspirin regularly.

Contrary to the findings in some previous studies,^15-17 however, our analysis suggested that women had a higher adjusted odds of regular aspirin use compared with men. This result should be interpreted with extreme caution, however, because so few females (9 of 464 [3%]) met the current USPSTF criteria for aspirin therapy for primary CVD prevention. The previous USPSTF guidelines^24,25 were less conservative, with a lower minimum age and threshold for CVD risk for women. The revision is the likely result of recent primary prevention trials¹⁰ that found regular aspirin use provided less cardioprotection for younger women.

The sample without an aspirin indication—roughly twice the size of the group with an aspirin indication (563 vs 268), which is reflective of the general population of Wisconsin—was useful in highlighting inappropriate use. There were clear indications of aspirin overuse in this group, with 18% of the sample reporting that they took aspirin regularly. The finding that inappropriate aspirin use was more likely in non-Hispanic whites vs minorities is similar to the result of an earlier study in which blacks, Hispanics, and Chinese Americans with low CVD risk were much less likely to report regular aspirin use compared with whites at low risk.¹⁵

The main concern with regular aspirin use in those for whom it is not indicated for primary CVD prevention is the risk of upper gastrointestinal bleeding and, less commonly, hemorrhagic stroke.²⁶ To illustrate this point, consider the following: About 10% of SHOW participants ages 35 to 74 years had no history of CVD and no indication for aspirin therapy based on the latest USPSTF guidelines, but took aspirin regularly nonetheless. Extrapolating those numbers to the entire state of Wisconsin would suggest that approximately 270,000 state residents have a similar profile. Assuming an extra 1.3 major bleeding events per 1000 person-years of regular aspirin use (as a meta-analysis of studies of adverse events associated with antiplatelet therapy found),²⁷ that would translate into an estimated 350 major bleeding events per year in Wisconsin that are attributable to aspirin overuse.

In view of the current USPSTF recommendations,¹⁰ aspirin is not optimally utilized by Wisconsin residents for the primary prevention of CVD. Aspirin therapy is not used enough by those with a high CVD risk, who could derive substantial vascular disease protection from it. Conversely, aspirin therapy is overused by those with a low CVD risk, for whom the risk of major bleeding is significantly higher than the potential for vascular disease protection. Furthermore, younger individuals at high CVD risk appear to be least likely to take aspirin regularly.

Recommendations
The strongest modifiable predictor of regular aspirin use is a recommendation from a clinician.¹³ Therefore, we recommend stronger primary care initiatives to ensure that patients are screened for aspirin use more frequently, particularly middle-aged men at high CVD risk. This clinic-based initiative could reach a larger proportion of the general population when combined with broader, community-oriented CVD preventive services.²⁸

More precise marketing and education are also needed. Because aspirin is a low-cost over-the-counter product that leads the consumer market for analgesics,²⁹ the general public (and older, non-Hispanic whites, in particular) needs to be better informed about the risks of medically inappropriate aspirin use for primary CVD prevention.

Study limitations
Selection and measurement biases were among the chief study limitations.

Study (SHOW) enrollment rate was slightly above 50%, with steady increases in enrollment each year (from 46% in 2008-2009 to 56% in 2010) due to expanded recruitment and consolidation of field operations.

Aspirin use was self-reported, and SHOW did not capture the reason for taking it (eg, CVD prevention or pain management). Some evidence of overreporting of aspirin use among older individuals exists,³⁰ suggesting that a more objective measure of aspirin use (eg, pill bottle verification or blood platelet aggregation test) could yield different results.

Certain confounders were not measured, most notably contraindications to aspirin (eg, genetic platelet abnormalities). Such findings could explain some patterns of aspirin use in both strata, as up to 10% of any given population has a contraindication to aspirin due to allergy, intolerance, gastrointestinal ulcer, concomitant anticoagulant medication, or other high bleeding risk.^18,31 Few of these variables were known about our sample.

TABLE 4W (available below) provides a breakdown of some possible aspirin contraindications, as well as possible reasons other than primary CVD prevention for regular aspirin use. Because clinical judgment is often required to assess the degree of severity of a given health condition in order to deem it an aspirin contraindication, these findings could not reliably be used to reclassify participants. We present them simply for hypothesis generation.

Some data collection predates the current USPSTF guidelines,¹⁰ which could have resulted in a misclassification of participants’ aspirin indication. However, sensitivity analyses restricted to the 2010 sample alone—the only one with data collection after the newer guidelines were released—did not reveal any meaningful differences.

Other methodological limitations include the less racially diverse population of Wisconsin compared with other parts of the country and the sample size, which did not permit testing for statistical interactions and perhaps resulted in larger confidence intervals for some associations (eg, race/ethnicity) relative to the population as a whole.

TABLE 4W
Possible reasons for aspirin use—or contraindication— by aspirin indication*

Acknowledgement

The authors thank Matt Walsh, PhD, for his assistance in creating the analytical dataset, as well as Sally Steward-Townsend, Susan Wright, Bri Deyo, Bethany Varley, and the rest of the Survey of the Health of Wisconsin staff.

CORRESPONDENCE Jeffrey J. VanWormer, PhD, Epidemiology Research Center, Marshfield Clinic Research Foundation, 1000 North Oak Avenue, Marshfield, WI 54449; [email protected]

Cardiovascular disease (CVD) is the principal cause of death in the United States.¹ As the population grows older and obesity and diabetes become increasingly prevalent, the prevalence of CVD is also expected to rise.^2,3 Fortunately, many CVD events can be prevented or delayed by modifying risk factors such as hyperlipidemia, hypertension, and smoking. Interventions associated with a reduction in risk have led to a reduction in CVD events^4,5 and contributed to a steady decline in cardiac deaths.⁶

Control of platelet aggregation is a cornerstone of primary CVD prevention.⁷ In an outpatient setting, this usually translates into identifying patients who are at high risk for a CVD event and advising them to take low-dose aspirin daily or every other day. Although not without controversy,^8,9 the US Preventive Services Task Force (USPSTF) recommends regular aspirin use for primary CVD prevention for middle-aged to older men at high risk for myocardial infarction (MI) and women at high risk for ischemic stroke.¹⁰

The efficacy of this intervention is proven: In primary prevention trials, regular aspirin use is associated with a 14% reduction in the likelihood of CVD events over 7 years.¹¹ What’s more, aspirin therapy, as recommended by the USPSTF, is among the most cost-effective clinic-based preventive measures.¹²

In 2004, 41% of US adults age 40 or older reported taking aspirin regularly¹³ —an increase of approximately 20% since 1999.¹⁴ More recent data from a national population-based cohort study found that 41% of adults ages 45 to 90 years who did not have CVD but were at moderate to high risk for a CVD event reported taking aspirin ≥3 days per week.¹⁵ In the same study, almost one-fourth of those at low CVD risk also reported regular aspirin use.

While regular aspirin use for primary CVD prevention has been on the rise,^13,14 the extent to which this intervention has penetrated various segments of the population is unclear. Several studies have found that aspirin use is consistently highest among those who are older, male, and white.^15-17 Other socioeconomic variables (eg, education level, employment, marital status) have received little attention. And no previous study has used national guidelines for aspirin therapy to stratify samples.

A look at overuse and underuse. To ensure that aspirin therapy for primary CVD prevention is directed at those who are most likely to benefit from it, a better understanding of variables associated with both aspirin overuse and underuse is needed. This area of research is important, in part because direct-to-consumer aspirin marketing may be particularly influential among groups at low risk for CVD—for whom the risk of excess bleeding outweighs the potential for disease prevention.^13,18

This study was undertaken to examine the association between specific sociodemographic variables and aspirin use among a representative sample of Wisconsin adults without CVD, looking both at those for whom aspirin therapy is indicated and those for whom it is not indicated based on national guidelines.

Methods

Design
We used a cross-sectional design, with data from the Survey of the Health of Wisconsin (SHOW),¹⁹ an annual survey of Wisconsin residents ages 21 to 74 years. SHOW uses a 2-stage stratified cluster sampling design to select households, with all age-eligible household members invited to participate. Recruitment for the annual survey consists of general community-wide announcements, as well as an initial letter and up to 6 visits to the randomly selected households to encourage participation.

By the end of 2010, SHOW had 1572 enrollees—about 53% of all eligible invitees. The demographic profile of SHOW enrollees was similar to US census data for all Wisconsin adults during the same time frame.¹⁹ All SHOW procedures were approved by the University of Wisconsin Institutional Review Board, and all participants provided informed consent.

Study sample
Our analyses were based on data provided by SHOW participants who were screened and enrolled between 2008 and 2010. To be included in our study, participants had to be between the ages of 35 and 74 years; not pregnant, on active military duty, or institutionalized; and have no personal history of CVD (myocardial infarction, angina, stroke, or transient ischemic attack) or CVD risk equivalent (type 1 or type 2 diabetes) at the time of recruitment. Data on key study variables had to be available, as well. (We used 35 years as the lower age limit because of the very low likelihood of CVD in younger individuals.)

We stratified the analytical sample (N=831) into 2 groups—participants for whom aspirin therapy was indicated and those for whom it was not indicated—in order to examine aspirin’s appropriate (recommended) and inappropriate use.

Measures
Outcome. The outcome variable was aspirin use. SHOW had asked participants how often they took aspirin. Similar to the methods used by Sanchez et al,¹⁵ we classified those who reported taking aspirin most (≥4) days of the week as regular aspirin users. All others were classified as nonregular aspirin users. Participants were not asked about the daily dose or weekly volume of aspirin.

Variables
Sociodemographic variables considered in our analysis were age, sex, race/ethnicity, education level, marital/partner status, employment status, health insurance, and region of residence within Wisconsin.

All participants underwent physical examinations, conducted as part of SHOW, at either a permanent or mobile exam center. Blood pressure was measured after a 5-minute rest period in a seated position, and the average of the last 2 out of 3 consecutive measurements was reported. Body mass index (BMI) was calculated, and blood samples were obtained by venipuncture, processed immediately, and sent to the Marshfield Clinic laboratory for measuring total and high-density lipoprotein (HDL) cholesterol.

Indications for aspirin therapy. We stratified the sample by those who were and those who were not candidates for aspirin therapy for primary CVD prevention based on the latest guidelines from the USPSTF ( FIGURE ).¹⁰ The Task Force recommends aspirin therapy for men ages 45 to 74 years with a moderate or greater 10-year risk of a coronary heart disease (CHD) event and women ages 55 to 74 years with a moderate or greater 10-year risk of stroke. We used the global CVD risk equation derived from the Framingham Heart Study (based on age, sex, smoking status, systolic blood pressure, and total and HDL cholesterol) to calculate each participant’s 10-year risk and, thus, determine whether aspirin therapy was or was not indicated.²⁰ Total and HDL cholesterol values were missing for 94 participants in the analytical sample; their 10-year CVD risk was estimated using BMI, a reasonable alternative to more conventional CVD risk prediction when laboratory values are unavailable.²¹

FIGURE
Study (SHOW) sample, stratified based on aspirin indication¹⁰

Statistical analyses
All analytical procedures were conducted using Statistical Analysis Software (SAS Version 9.2; Cary, NC). A complete-case framework was used.

We used multivariate logistic regression for survey data (PROC SURVEYLOGISTIC; SAS Institute, Cary, NC) to examine the association between aspirin use and sociodemographic variables. Two separate analyses were conducted, one of participants for whom aspirin therapy was indicated and the other for participants for whom it was not. The outcomes were modeled dichotomously, as regular vs nonregular aspirin users, and a collinearity check was done. ²¹

Initially, we created univariate models to gauge the crude relationship between each variable and aspirin use. Any variable with P<.20 in its univariate association with regular aspirin use was considered for inclusion in the final multivariate regression model. In the multivariate analyses, we sequentially eliminated variables with the weakest association with aspirin use until only significant (P<.10) independent predictors remained. Appropriate weighting was applied based on survey strata and cluster structure.¹⁹

Results

Of the 831 participants who met the eligibility criteria for our analysis, 268 (32%) had an aspirin indication. TABLE 1 shows the key characteristics of the analytical sample, stratified by those for whom aspirin was indicated and those for whom it was not. The sample was primarily middle-aged (mean age 52.4±0.36) and non-Hispanic white (93%). Compared with those for whom aspirin therapy was not indicated, the group with an aspirin indication was significantly older (56.9 vs 50.3) and had a significantly higher proportion of males (97% vs 19%). As expected, those for whom aspirin was indicated were also at higher risk for CHD and stroke, most notably as a result of significantly higher systolic BP (131.9 vs 121.5 mm Hg) and lower HDL cholesterol (42.5 vs 52.6 mg/dL) compared with participants without an aspirin indication.

TABLE 1
Study sample, by sociodemographic variable and aspirin indication

When aspirin was indicated, use was linked to age and sex
In the group with an aspirin indication (n=268), 83 (31%) reported taking aspirin most days of the week. The initial examination of sociodemographic variables showed that age, sex, and employment status demonstrated significant univariate associations with regular aspirin use ( TABLE 2 ). In the multivariate model, however, the odds of regular aspirin use were significantly greater among participants who were older (odds ratio [OR], 1.07; P<.001) or female (OR, 3.49; P=.021) compared with participants who were younger or male, respectively.

TABLE 2
Participants who have an aspirin indication: Association between sociodemographic variables and regular aspirin use

When aspirin was not indicated, age and sex still affected use
Among the 563 participants for whom aspirin therapy was not indicated, 102 (18%) reported taking aspirin regularly. Age, sex, race/ethnicity, health insurance, and employment ( TABLE 3 ), as well as region of residence and study enrollment year, had significant univariate associations with regular aspirin use; these variables were tested for potential inclusion in the multivariate model. In the final multivariate regression model, the odds of regular aspirin use were significantly greater among participants who were older (OR, 1.07; P<.001) and significantly lower among participants who were Hispanic or nonwhite (OR, 0.32; P=.063).

TABLE 3
Participants who do not have an aspirin indication: Association between sociodemographic variables and regular aspirin use

Discussion

Aspirin was generally underutilized in the group with significant CVD risk (n=268) in our study, with slightly less than a third of participants for whom aspirin therapy was indicated taking it most days of the week. Despite trends of increased aspirin use among US adults in recent years,¹⁵ aspirin therapy in the 2008-2010 SHOW sample was lower than in 2005 to 2008. It was also lower than national estimates of aspirin use for primary CVD prevention^15,22 —but about 20% higher than estimates of overall aspirin use in Wisconsin 20 years ago.²³ Consistent with previous research, the final adjusted model and sensitivity analysis indicated that older individuals were more likely to take aspirin regularly.

Contrary to the findings in some previous studies,^15-17 however, our analysis suggested that women had a higher adjusted odds of regular aspirin use compared with men. This result should be interpreted with extreme caution, however, because so few females (9 of 464 [3%]) met the current USPSTF criteria for aspirin therapy for primary CVD prevention. The previous USPSTF guidelines^24,25 were less conservative, with a lower minimum age and threshold for CVD risk for women. The revision is the likely result of recent primary prevention trials¹⁰ that found regular aspirin use provided less cardioprotection for younger women.

The sample without an aspirin indication—roughly twice the size of the group with an aspirin indication (563 vs 268), which is reflective of the general population of Wisconsin—was useful in highlighting inappropriate use. There were clear indications of aspirin overuse in this group, with 18% of the sample reporting that they took aspirin regularly. The finding that inappropriate aspirin use was more likely in non-Hispanic whites vs minorities is similar to the result of an earlier study in which blacks, Hispanics, and Chinese Americans with low CVD risk were much less likely to report regular aspirin use compared with whites at low risk.¹⁵

The main concern with regular aspirin use in those for whom it is not indicated for primary CVD prevention is the risk of upper gastrointestinal bleeding and, less commonly, hemorrhagic stroke.²⁶ To illustrate this point, consider the following: About 10% of SHOW participants ages 35 to 74 years had no history of CVD and no indication for aspirin therapy based on the latest USPSTF guidelines, but took aspirin regularly nonetheless. Extrapolating those numbers to the entire state of Wisconsin would suggest that approximately 270,000 state residents have a similar profile. Assuming an extra 1.3 major bleeding events per 1000 person-years of regular aspirin use (as a meta-analysis of studies of adverse events associated with antiplatelet therapy found),²⁷ that would translate into an estimated 350 major bleeding events per year in Wisconsin that are attributable to aspirin overuse.

In view of the current USPSTF recommendations,¹⁰ aspirin is not optimally utilized by Wisconsin residents for the primary prevention of CVD. Aspirin therapy is not used enough by those with a high CVD risk, who could derive substantial vascular disease protection from it. Conversely, aspirin therapy is overused by those with a low CVD risk, for whom the risk of major bleeding is significantly higher than the potential for vascular disease protection. Furthermore, younger individuals at high CVD risk appear to be least likely to take aspirin regularly.

Recommendations
The strongest modifiable predictor of regular aspirin use is a recommendation from a clinician.¹³ Therefore, we recommend stronger primary care initiatives to ensure that patients are screened for aspirin use more frequently, particularly middle-aged men at high CVD risk. This clinic-based initiative could reach a larger proportion of the general population when combined with broader, community-oriented CVD preventive services.²⁸

More precise marketing and education are also needed. Because aspirin is a low-cost over-the-counter product that leads the consumer market for analgesics,²⁹ the general public (and older, non-Hispanic whites, in particular) needs to be better informed about the risks of medically inappropriate aspirin use for primary CVD prevention.

Study limitations
Selection and measurement biases were among the chief study limitations.

Study (SHOW) enrollment rate was slightly above 50%, with steady increases in enrollment each year (from 46% in 2008-2009 to 56% in 2010) due to expanded recruitment and consolidation of field operations.

Aspirin use was self-reported, and SHOW did not capture the reason for taking it (eg, CVD prevention or pain management). Some evidence of overreporting of aspirin use among older individuals exists,³⁰ suggesting that a more objective measure of aspirin use (eg, pill bottle verification or blood platelet aggregation test) could yield different results.

Certain confounders were not measured, most notably contraindications to aspirin (eg, genetic platelet abnormalities). Such findings could explain some patterns of aspirin use in both strata, as up to 10% of any given population has a contraindication to aspirin due to allergy, intolerance, gastrointestinal ulcer, concomitant anticoagulant medication, or other high bleeding risk.^18,31 Few of these variables were known about our sample.

TABLE 4W (available below) provides a breakdown of some possible aspirin contraindications, as well as possible reasons other than primary CVD prevention for regular aspirin use. Because clinical judgment is often required to assess the degree of severity of a given health condition in order to deem it an aspirin contraindication, these findings could not reliably be used to reclassify participants. We present them simply for hypothesis generation.

Some data collection predates the current USPSTF guidelines,¹⁰ which could have resulted in a misclassification of participants’ aspirin indication. However, sensitivity analyses restricted to the 2010 sample alone—the only one with data collection after the newer guidelines were released—did not reveal any meaningful differences.

Other methodological limitations include the less racially diverse population of Wisconsin compared with other parts of the country and the sample size, which did not permit testing for statistical interactions and perhaps resulted in larger confidence intervals for some associations (eg, race/ethnicity) relative to the population as a whole.

TABLE 4W
Possible reasons for aspirin use—or contraindication— by aspirin indication*

Acknowledgement

The authors thank Matt Walsh, PhD, for his assistance in creating the analytical dataset, as well as Sally Steward-Townsend, Susan Wright, Bri Deyo, Bethany Varley, and the rest of the Survey of the Health of Wisconsin staff.

CORRESPONDENCE Jeffrey J. VanWormer, PhD, Epidemiology Research Center, Marshfield Clinic Research Foundation, 1000 North Oak Avenue, Marshfield, WI 54449; [email protected]

Background: The Hispanic population accounts for 15% of the population of the United States, and for as much as 75% in cities throughout California. Racial disparities that are reflected by limited access to health care and worse disease outcomes are well documented for adult Hispanic cancer patients.

Objective: To determine whether there are similar disparities—including delays in accessing surgery, radiation, and oncologic care—for adult Hispanic non English-speaking (HNES) neuro-oncology patients and white English-only–speaking (WES) patients in an academic, tertiary care center with a multidisciplinary neuro-oncology team.

Methods: This retrospective study was conducted at the Chao Family Comprehensive Cancer Center of the University of California, Irvine. All patients who were diagnosed with a primary brain tumor during January 1, 2003, to December 31, 2008, were identified and data were collected on their age, sex, ethnicity, languages spoken, diagnosis, and insurance status. The times from the date of diagnosis to the date of surgery, from the date of surgery to the date of starting radiation (if indicated), and from the date of finishing radiation to the date of starting chemotherapy (if indicated) were also recorded.

Results: Most of the HNES patients (56.4%) had state insurance for the indigent, whereas most of the WES patients (41.8%) had private insurance from a health maintenance organization. Moreover, 12.8% of HNES patients were uninsured, compared with 4.5% of WES patients. There were no significant delays in the time from diagnosis to surgery, but there was a significant delay in access to radiation treatment (P   .023). There were no differences on overall survival between the 2 groups of patients.

Limitations: This is a retrospective study of a relatively small number of patients. Larger studies are needed to corroborate these findings

Conclusions: The findings demonstrate that there are disparities in insurance status and access to radiation therapy between HNES and WES neuro-oncology patients.

*To read the the full article, click on the link at the top of this introduction.

Background: The Hispanic population accounts for 15% of the population of the United States, and for as much as 75% in cities throughout California. Racial disparities that are reflected by limited access to health care and worse disease outcomes are well documented for adult Hispanic cancer patients.

Objective: To determine whether there are similar disparities—including delays in accessing surgery, radiation, and oncologic care—for adult Hispanic non English-speaking (HNES) neuro-oncology patients and white English-only–speaking (WES) patients in an academic, tertiary care center with a multidisciplinary neuro-oncology team.

Methods: This retrospective study was conducted at the Chao Family Comprehensive Cancer Center of the University of California, Irvine. All patients who were diagnosed with a primary brain tumor during January 1, 2003, to December 31, 2008, were identified and data were collected on their age, sex, ethnicity, languages spoken, diagnosis, and insurance status. The times from the date of diagnosis to the date of surgery, from the date of surgery to the date of starting radiation (if indicated), and from the date of finishing radiation to the date of starting chemotherapy (if indicated) were also recorded.

Results: Most of the HNES patients (56.4%) had state insurance for the indigent, whereas most of the WES patients (41.8%) had private insurance from a health maintenance organization. Moreover, 12.8% of HNES patients were uninsured, compared with 4.5% of WES patients. There were no significant delays in the time from diagnosis to surgery, but there was a significant delay in access to radiation treatment (P   .023). There were no differences on overall survival between the 2 groups of patients.

Limitations: This is a retrospective study of a relatively small number of patients. Larger studies are needed to corroborate these findings

Conclusions: The findings demonstrate that there are disparities in insurance status and access to radiation therapy between HNES and WES neuro-oncology patients.

*To read the the full article, click on the link at the top of this introduction.

Background: The Hispanic population accounts for 15% of the population of the United States, and for as much as 75% in cities throughout California. Racial disparities that are reflected by limited access to health care and worse disease outcomes are well documented for adult Hispanic cancer patients.

Objective: To determine whether there are similar disparities—including delays in accessing surgery, radiation, and oncologic care—for adult Hispanic non English-speaking (HNES) neuro-oncology patients and white English-only–speaking (WES) patients in an academic, tertiary care center with a multidisciplinary neuro-oncology team.

Methods: This retrospective study was conducted at the Chao Family Comprehensive Cancer Center of the University of California, Irvine. All patients who were diagnosed with a primary brain tumor during January 1, 2003, to December 31, 2008, were identified and data were collected on their age, sex, ethnicity, languages spoken, diagnosis, and insurance status. The times from the date of diagnosis to the date of surgery, from the date of surgery to the date of starting radiation (if indicated), and from the date of finishing radiation to the date of starting chemotherapy (if indicated) were also recorded.

Results: Most of the HNES patients (56.4%) had state insurance for the indigent, whereas most of the WES patients (41.8%) had private insurance from a health maintenance organization. Moreover, 12.8% of HNES patients were uninsured, compared with 4.5% of WES patients. There were no significant delays in the time from diagnosis to surgery, but there was a significant delay in access to radiation treatment (P   .023). There were no differences on overall survival between the 2 groups of patients.

Limitations: This is a retrospective study of a relatively small number of patients. Larger studies are needed to corroborate these findings

Conclusions: The findings demonstrate that there are disparities in insurance status and access to radiation therapy between HNES and WES neuro-oncology patients.

*To read the the full article, click on the link at the top of this introduction.

Recent guidance from the Centers for Medicare and Medicaid Services restricting erythropoiesis-stimulating agents (ESAs) in chemotherapy and cancer-related anemias has resulted in an increase in transfusions. Nine studies, without published contradictory evidence, have shown optimization of the response to ESAs by intravenous (IV) iron when the iron was added to the treatment of chemotherapy-induced anemia. The synergy observed, although greater in iron deficiency, was independent of pretreatment iron parameters. Three studies demonstrated decreased transfusions when IV iron is administered without ESAs. Discordant recommendations regarding IV iron currently exist among the American Society of Hematology/American Society of Clinical Oncology guidelines, the National Comprehensive Cancer Network, and the European Society of Medical Oncology. This discordance is at least partly the result of misconceptions about the clinical nature and incidence of adverse effects with IV iron. Other reasons for this discordance are presented in this review. Based on thousands of studied patients, we conclude that IV iron is safe and probably safer than most physicians realize. Education is needed relating to the interpretation of minor, subclinical infusion reactions that resolve without therapy. IV iron without ESAs may be an effective treatment for chemotherapy-induced anemia and warrants further study. We present evidence supporting the conclusion that baseline serum hepcidin levels may predict responses to IV iron, and we examine the published evidence supporting the conclusion that IV iron should be a standard addition to the management of chemotherapy and cancer-related anemia.

Click on the PDF icon at the top of this introduction to read the full article.

Recent guidance from the Centers for Medicare and Medicaid Services restricting erythropoiesis-stimulating agents (ESAs) in chemotherapy and cancer-related anemias has resulted in an increase in transfusions. Nine studies, without published contradictory evidence, have shown optimization of the response to ESAs by intravenous (IV) iron when the iron was added to the treatment of chemotherapy-induced anemia. The synergy observed, although greater in iron deficiency, was independent of pretreatment iron parameters. Three studies demonstrated decreased transfusions when IV iron is administered without ESAs. Discordant recommendations regarding IV iron currently exist among the American Society of Hematology/American Society of Clinical Oncology guidelines, the National Comprehensive Cancer Network, and the European Society of Medical Oncology. This discordance is at least partly the result of misconceptions about the clinical nature and incidence of adverse effects with IV iron. Other reasons for this discordance are presented in this review. Based on thousands of studied patients, we conclude that IV iron is safe and probably safer than most physicians realize. Education is needed relating to the interpretation of minor, subclinical infusion reactions that resolve without therapy. IV iron without ESAs may be an effective treatment for chemotherapy-induced anemia and warrants further study. We present evidence supporting the conclusion that baseline serum hepcidin levels may predict responses to IV iron, and we examine the published evidence supporting the conclusion that IV iron should be a standard addition to the management of chemotherapy and cancer-related anemia.

Click on the PDF icon at the top of this introduction to read the full article.

Recent guidance from the Centers for Medicare and Medicaid Services restricting erythropoiesis-stimulating agents (ESAs) in chemotherapy and cancer-related anemias has resulted in an increase in transfusions. Nine studies, without published contradictory evidence, have shown optimization of the response to ESAs by intravenous (IV) iron when the iron was added to the treatment of chemotherapy-induced anemia. The synergy observed, although greater in iron deficiency, was independent of pretreatment iron parameters. Three studies demonstrated decreased transfusions when IV iron is administered without ESAs. Discordant recommendations regarding IV iron currently exist among the American Society of Hematology/American Society of Clinical Oncology guidelines, the National Comprehensive Cancer Network, and the European Society of Medical Oncology. This discordance is at least partly the result of misconceptions about the clinical nature and incidence of adverse effects with IV iron. Other reasons for this discordance are presented in this review. Based on thousands of studied patients, we conclude that IV iron is safe and probably safer than most physicians realize. Education is needed relating to the interpretation of minor, subclinical infusion reactions that resolve without therapy. IV iron without ESAs may be an effective treatment for chemotherapy-induced anemia and warrants further study. We present evidence supporting the conclusion that baseline serum hepcidin levels may predict responses to IV iron, and we examine the published evidence supporting the conclusion that IV iron should be a standard addition to the management of chemotherapy and cancer-related anemia.

Click on the PDF icon at the top of this introduction to read the full article.

Counsel parents in your practice that young children can be seriously injured or die from playing with or ingesting button batteries.

Injuries from these coin-sized batteries are on the rise, with 2.5 times as many children under age 13 showing up at an emergency department in 2010 compared with 1998, according to a study in the Aug. 31 issue of Morbidity and Mortality Weekly Report (2012:61:661-6). This increase from 1,900 cases in 1998 to 4,800 in 2010 aligns with the growing popularity of these batteries in remote controls, toys, light-up jewelry, and other devices.

Hemera/iStockphotos.com

"As the use of these batteries expands, so do the estimated number of ED-treated battery exposures in children, with the vast majority of these involving ingestions," Jacqueline Ferrante, Ph.D., of the U.S. Consumer Product Safety Commission (CPSC) Division of Health Sciences, and her colleagues stated in the report.

Injuries from batteries placed in a child’s nose or acid burns from ruptured batteries also are included in the report.

"Ensure that parents are aware of the problem so that batteries are kept away from young children," Dr. Ferrante said in an interview. Advise them to check remote controls and other electronic devices for easily accessible battery compartments, especially those that can be opened without a screwdriver, she advised.

An estimated 40,400 children younger than 13 years were treated at U.S. emergency departments for battery-related injuries between 1997 and 2010.

Additional CPSC databases covering 1995-2010 were searched for battery-related deaths in children under age 13. Of the 14 reported deaths, 12 children had confirmed exposure to button cell batteries. All children who died were aged 4 years and younger.

Diagnosis can be a challenge. Not all children can or are willing to report swallowing a battery or giving one to a sibling, the authors noted. In addition, the typical vomiting, abdominal pain, fever, diarrhea, respiratory distress, and dysphagia associated with battery ingestion are nonspecific symptoms (Pediatr. Emerg. Care 2008;24:313-6).

"Consider battery ingestion in the differential diagnosis of any child presenting with nonspecific GI symptoms or unexplained respiratory distress because of the serious consequences associated with a delayed or missed diagnosis," Dr. Ferrante said.

Complicating matters is the timing of injury, which can vary from 2 hours after ingestion for serious esophageal burns to more than 2 weeks for fatal hemorrhage following endoscopic removal of a button battery. The growing recognition of these injuries drove pediatric gastroenterologists at the University of Colorado Denver to develop guidelines for the management of button battery–induced hemorrhage (J. Pediatr. Gastroenterol. Nutr. 2011;52:585-9).

Nickle-sized, 3-V lithium button batteries can easily lodge in a child’s esophagus, and were most frequently associated with serious complications and death, according to the report.

Although outside the scope of the report, Dr. Ferrante also suggested pediatricians warn parents about ingestion of strong powerful magnets. This is another often-overlooked injury with similar issues and consequences, she said. "There are even cases where injury resulted from co-ingestion of a button battery and a strong magnet."

For the current study, Dr. Ferrante and her colleagues analyzed the National Electronic Injury Surveillance System (NEISS) database to quantify nonfatal, battery-related ED visits. They assessed other CPSC data to identify the battery-related deaths.

The NEISS data only comprise emergency department visits, so any child treated for battery ingestion in a doctor’s office or as an outpatient is not included in the study, a potential limitation. In addition, the number of fatal incidents involving batteries and children younger than 13 years is likely underrepresented because of the type of data collected, the authors noted.

The authors had no relevant financial disclosures. Click here for more information on battery hazards provided by the U.S. Consumer Product Safety Commission.

Counsel parents in your practice that young children can be seriously injured or die from playing with or ingesting button batteries.

Injuries from these coin-sized batteries are on the rise, with 2.5 times as many children under age 13 showing up at an emergency department in 2010 compared with 1998, according to a study in the Aug. 31 issue of Morbidity and Mortality Weekly Report (2012:61:661-6). This increase from 1,900 cases in 1998 to 4,800 in 2010 aligns with the growing popularity of these batteries in remote controls, toys, light-up jewelry, and other devices.

Hemera/iStockphotos.com

"As the use of these batteries expands, so do the estimated number of ED-treated battery exposures in children, with the vast majority of these involving ingestions," Jacqueline Ferrante, Ph.D., of the U.S. Consumer Product Safety Commission (CPSC) Division of Health Sciences, and her colleagues stated in the report.

Injuries from batteries placed in a child’s nose or acid burns from ruptured batteries also are included in the report.

"Ensure that parents are aware of the problem so that batteries are kept away from young children," Dr. Ferrante said in an interview. Advise them to check remote controls and other electronic devices for easily accessible battery compartments, especially those that can be opened without a screwdriver, she advised.

An estimated 40,400 children younger than 13 years were treated at U.S. emergency departments for battery-related injuries between 1997 and 2010.

Additional CPSC databases covering 1995-2010 were searched for battery-related deaths in children under age 13. Of the 14 reported deaths, 12 children had confirmed exposure to button cell batteries. All children who died were aged 4 years and younger.

Diagnosis can be a challenge. Not all children can or are willing to report swallowing a battery or giving one to a sibling, the authors noted. In addition, the typical vomiting, abdominal pain, fever, diarrhea, respiratory distress, and dysphagia associated with battery ingestion are nonspecific symptoms (Pediatr. Emerg. Care 2008;24:313-6).

"Consider battery ingestion in the differential diagnosis of any child presenting with nonspecific GI symptoms or unexplained respiratory distress because of the serious consequences associated with a delayed or missed diagnosis," Dr. Ferrante said.

Complicating matters is the timing of injury, which can vary from 2 hours after ingestion for serious esophageal burns to more than 2 weeks for fatal hemorrhage following endoscopic removal of a button battery. The growing recognition of these injuries drove pediatric gastroenterologists at the University of Colorado Denver to develop guidelines for the management of button battery–induced hemorrhage (J. Pediatr. Gastroenterol. Nutr. 2011;52:585-9).

Nickle-sized, 3-V lithium button batteries can easily lodge in a child’s esophagus, and were most frequently associated with serious complications and death, according to the report.

Although outside the scope of the report, Dr. Ferrante also suggested pediatricians warn parents about ingestion of strong powerful magnets. This is another often-overlooked injury with similar issues and consequences, she said. "There are even cases where injury resulted from co-ingestion of a button battery and a strong magnet."

For the current study, Dr. Ferrante and her colleagues analyzed the National Electronic Injury Surveillance System (NEISS) database to quantify nonfatal, battery-related ED visits. They assessed other CPSC data to identify the battery-related deaths.

The NEISS data only comprise emergency department visits, so any child treated for battery ingestion in a doctor’s office or as an outpatient is not included in the study, a potential limitation. In addition, the number of fatal incidents involving batteries and children younger than 13 years is likely underrepresented because of the type of data collected, the authors noted.

The authors had no relevant financial disclosures. Click here for more information on battery hazards provided by the U.S. Consumer Product Safety Commission.

Counsel parents in your practice that young children can be seriously injured or die from playing with or ingesting button batteries.

Injuries from these coin-sized batteries are on the rise, with 2.5 times as many children under age 13 showing up at an emergency department in 2010 compared with 1998, according to a study in the Aug. 31 issue of Morbidity and Mortality Weekly Report (2012:61:661-6). This increase from 1,900 cases in 1998 to 4,800 in 2010 aligns with the growing popularity of these batteries in remote controls, toys, light-up jewelry, and other devices.

Hemera/iStockphotos.com

"As the use of these batteries expands, so do the estimated number of ED-treated battery exposures in children, with the vast majority of these involving ingestions," Jacqueline Ferrante, Ph.D., of the U.S. Consumer Product Safety Commission (CPSC) Division of Health Sciences, and her colleagues stated in the report.

Injuries from batteries placed in a child’s nose or acid burns from ruptured batteries also are included in the report.

"Ensure that parents are aware of the problem so that batteries are kept away from young children," Dr. Ferrante said in an interview. Advise them to check remote controls and other electronic devices for easily accessible battery compartments, especially those that can be opened without a screwdriver, she advised.

An estimated 40,400 children younger than 13 years were treated at U.S. emergency departments for battery-related injuries between 1997 and 2010.

Additional CPSC databases covering 1995-2010 were searched for battery-related deaths in children under age 13. Of the 14 reported deaths, 12 children had confirmed exposure to button cell batteries. All children who died were aged 4 years and younger.

Diagnosis can be a challenge. Not all children can or are willing to report swallowing a battery or giving one to a sibling, the authors noted. In addition, the typical vomiting, abdominal pain, fever, diarrhea, respiratory distress, and dysphagia associated with battery ingestion are nonspecific symptoms (Pediatr. Emerg. Care 2008;24:313-6).

"Consider battery ingestion in the differential diagnosis of any child presenting with nonspecific GI symptoms or unexplained respiratory distress because of the serious consequences associated with a delayed or missed diagnosis," Dr. Ferrante said.

Complicating matters is the timing of injury, which can vary from 2 hours after ingestion for serious esophageal burns to more than 2 weeks for fatal hemorrhage following endoscopic removal of a button battery. The growing recognition of these injuries drove pediatric gastroenterologists at the University of Colorado Denver to develop guidelines for the management of button battery–induced hemorrhage (J. Pediatr. Gastroenterol. Nutr. 2011;52:585-9).

Nickle-sized, 3-V lithium button batteries can easily lodge in a child’s esophagus, and were most frequently associated with serious complications and death, according to the report.

Although outside the scope of the report, Dr. Ferrante also suggested pediatricians warn parents about ingestion of strong powerful magnets. This is another often-overlooked injury with similar issues and consequences, she said. "There are even cases where injury resulted from co-ingestion of a button battery and a strong magnet."

For the current study, Dr. Ferrante and her colleagues analyzed the National Electronic Injury Surveillance System (NEISS) database to quantify nonfatal, battery-related ED visits. They assessed other CPSC data to identify the battery-related deaths.

The NEISS data only comprise emergency department visits, so any child treated for battery ingestion in a doctor’s office or as an outpatient is not included in the study, a potential limitation. In addition, the number of fatal incidents involving batteries and children younger than 13 years is likely underrepresented because of the type of data collected, the authors noted.

The authors had no relevant financial disclosures. Click here for more information on battery hazards provided by the U.S. Consumer Product Safety Commission.

The Food and Drug Administration approved linaclotide on Aug. 30 to treat two conditions: chronic idiopathic constipation and irritable bowel syndrome with constipation in adults.

Linaclotide (Linzess) is administered as a capsule taken once daily on an empty stomach, at least 30 minutes before the first meal of the day. This agent helps relieve constipation by increasing the frequency of bowel movements. In irritable bowel syndrome with constipation (IBS-C), linaclotide has been shown to reduce abdominal pain, according to a statement from the FDA.

Photo istockphoto.com

The drug is approved with a boxed warning to alert patients and health care professionals that linaclotide should not be used in patients 16 years of age and younger. The most common side effect reported during the clinical studies was diarrhea, the statement said.

According to the FDA, the safety and effectiveness of linaclotide for the management of IBS-C were established in two double-blind studies (Gastroenterology 2011;140:S138 and Gastroenterology 2011;140:S135). A total of 1,604 patients were randomly assigned to take 290 mcg of linaclotide or a placebo for at least 12 weeks. Linaclotide was more effective in reducing abdominal pain and increasing the number of complete spontaneous bowel movements, compared with placebo, in both trials.

The safety and effectiveness of linaclotide for the management of chronic idiopathic constipation also were established in two double-blind studies (N. Engl. J. Med. 2011;365:527-36). A total of 1,272 patients were randomly assigned to take 145 mcg or 290 mcg linaclotide or a placebo for 12 weeks. Patients on linaclotide had more complete spontaneous bowel movements than did those taking the placebo. The 290-mcg dose is not approved for chronic constipation because the data showed that it was no more effective than the 145-mcg dose.

Linzess is marketed by Ironwood Pharmaceuticals Inc.

The Food and Drug Administration approved linaclotide on Aug. 30 to treat two conditions: chronic idiopathic constipation and irritable bowel syndrome with constipation in adults.

Linaclotide (Linzess) is administered as a capsule taken once daily on an empty stomach, at least 30 minutes before the first meal of the day. This agent helps relieve constipation by increasing the frequency of bowel movements. In irritable bowel syndrome with constipation (IBS-C), linaclotide has been shown to reduce abdominal pain, according to a statement from the FDA.

Photo istockphoto.com

The drug is approved with a boxed warning to alert patients and health care professionals that linaclotide should not be used in patients 16 years of age and younger. The most common side effect reported during the clinical studies was diarrhea, the statement said.

According to the FDA, the safety and effectiveness of linaclotide for the management of IBS-C were established in two double-blind studies (Gastroenterology 2011;140:S138 and Gastroenterology 2011;140:S135). A total of 1,604 patients were randomly assigned to take 290 mcg of linaclotide or a placebo for at least 12 weeks. Linaclotide was more effective in reducing abdominal pain and increasing the number of complete spontaneous bowel movements, compared with placebo, in both trials.

The safety and effectiveness of linaclotide for the management of chronic idiopathic constipation also were established in two double-blind studies (N. Engl. J. Med. 2011;365:527-36). A total of 1,272 patients were randomly assigned to take 145 mcg or 290 mcg linaclotide or a placebo for 12 weeks. Patients on linaclotide had more complete spontaneous bowel movements than did those taking the placebo. The 290-mcg dose is not approved for chronic constipation because the data showed that it was no more effective than the 145-mcg dose.

Linzess is marketed by Ironwood Pharmaceuticals Inc.

The Food and Drug Administration approved linaclotide on Aug. 30 to treat two conditions: chronic idiopathic constipation and irritable bowel syndrome with constipation in adults.

Linaclotide (Linzess) is administered as a capsule taken once daily on an empty stomach, at least 30 minutes before the first meal of the day. This agent helps relieve constipation by increasing the frequency of bowel movements. In irritable bowel syndrome with constipation (IBS-C), linaclotide has been shown to reduce abdominal pain, according to a statement from the FDA.

Photo istockphoto.com

The drug is approved with a boxed warning to alert patients and health care professionals that linaclotide should not be used in patients 16 years of age and younger. The most common side effect reported during the clinical studies was diarrhea, the statement said.

According to the FDA, the safety and effectiveness of linaclotide for the management of IBS-C were established in two double-blind studies (Gastroenterology 2011;140:S138 and Gastroenterology 2011;140:S135). A total of 1,604 patients were randomly assigned to take 290 mcg of linaclotide or a placebo for at least 12 weeks. Linaclotide was more effective in reducing abdominal pain and increasing the number of complete spontaneous bowel movements, compared with placebo, in both trials.

The safety and effectiveness of linaclotide for the management of chronic idiopathic constipation also were established in two double-blind studies (N. Engl. J. Med. 2011;365:527-36). A total of 1,272 patients were randomly assigned to take 145 mcg or 290 mcg linaclotide or a placebo for 12 weeks. Patients on linaclotide had more complete spontaneous bowel movements than did those taking the placebo. The 290-mcg dose is not approved for chronic constipation because the data showed that it was no more effective than the 145-mcg dose.

Linzess is marketed by Ironwood Pharmaceuticals Inc.

An author of new research that shows physicians are more likely to be burned out by work than other professions says the findings underscore the need for hospitalists to find a balance between their professional and personal lives.

The Archives of Internal Medicine report, "Burnout and Satisfaction With Work-Life Balance Among US Physicians Relative to the General U.S. Population," found that physicians were more likely than "working U.S. adults" to exhibit at least one symptom of burnout (37.9% vs. 27.8%, P<0.01). Physicians also were more likely to be dissatisfied with their work-life balance (40.2% vs. 23.2%, P<0.01), according to the data.

"It's a balancing act," says Colin West, MD, PhD, FACP, of the Departments of Internal Medicine and Health Sciences Research at Mayo Clinic in Rochester, Minn. "Every physician is a little bit different. Every person is a little bit different. If everyone is able to exert some control … and do what's meaningful to them, that gives them the best shot to balance."

Of specific importance for hospitalists, the research found that "front-line specialties" (including internal medicine, general medicine, and emergency medicine) exhibited the highest risk factor for burnout. Dr. West says more research would be required to determine how at risk hospitalists are, but given their position in the healthcare spectrum, he suspects they are among those at highest risk. He believes that the healthcare system as a whole needs to address the burnout issue, as repercussions can include problematic alcohol use, broken relationships, and suicidal ideation.

"The best group is that which strikes a balance," Dr. West says. "It's probably because [those physicians are not] feeling like they're dropping a ball. If you pick work over home, or home over work, then, basically, one is left behind."

An author of new research that shows physicians are more likely to be burned out by work than other professions says the findings underscore the need for hospitalists to find a balance between their professional and personal lives.

The Archives of Internal Medicine report, "Burnout and Satisfaction With Work-Life Balance Among US Physicians Relative to the General U.S. Population," found that physicians were more likely than "working U.S. adults" to exhibit at least one symptom of burnout (37.9% vs. 27.8%, P<0.01). Physicians also were more likely to be dissatisfied with their work-life balance (40.2% vs. 23.2%, P<0.01), according to the data.

"It's a balancing act," says Colin West, MD, PhD, FACP, of the Departments of Internal Medicine and Health Sciences Research at Mayo Clinic in Rochester, Minn. "Every physician is a little bit different. Every person is a little bit different. If everyone is able to exert some control … and do what's meaningful to them, that gives them the best shot to balance."

Of specific importance for hospitalists, the research found that "front-line specialties" (including internal medicine, general medicine, and emergency medicine) exhibited the highest risk factor for burnout. Dr. West says more research would be required to determine how at risk hospitalists are, but given their position in the healthcare spectrum, he suspects they are among those at highest risk. He believes that the healthcare system as a whole needs to address the burnout issue, as repercussions can include problematic alcohol use, broken relationships, and suicidal ideation.

"The best group is that which strikes a balance," Dr. West says. "It's probably because [those physicians are not] feeling like they're dropping a ball. If you pick work over home, or home over work, then, basically, one is left behind."

An author of new research that shows physicians are more likely to be burned out by work than other professions says the findings underscore the need for hospitalists to find a balance between their professional and personal lives.

The Archives of Internal Medicine report, "Burnout and Satisfaction With Work-Life Balance Among US Physicians Relative to the General U.S. Population," found that physicians were more likely than "working U.S. adults" to exhibit at least one symptom of burnout (37.9% vs. 27.8%, P<0.01). Physicians also were more likely to be dissatisfied with their work-life balance (40.2% vs. 23.2%, P<0.01), according to the data.

"It's a balancing act," says Colin West, MD, PhD, FACP, of the Departments of Internal Medicine and Health Sciences Research at Mayo Clinic in Rochester, Minn. "Every physician is a little bit different. Every person is a little bit different. If everyone is able to exert some control … and do what's meaningful to them, that gives them the best shot to balance."

Of specific importance for hospitalists, the research found that "front-line specialties" (including internal medicine, general medicine, and emergency medicine) exhibited the highest risk factor for burnout. Dr. West says more research would be required to determine how at risk hospitalists are, but given their position in the healthcare spectrum, he suspects they are among those at highest risk. He believes that the healthcare system as a whole needs to address the burnout issue, as repercussions can include problematic alcohol use, broken relationships, and suicidal ideation.

"The best group is that which strikes a balance," Dr. West says. "It's probably because [those physicians are not] feeling like they're dropping a ball. If you pick work over home, or home over work, then, basically, one is left behind."

Earlier this month CMS announced 17 additional awards under its Community-Based Care Transitions Program (CCTP), which now encompasses 200 acute-care hospitals and their hospitalists partnering with community agencies and coalitions to improve transitions of care in advance of the Oct. 1 start for excessive readmissions penalties. Innovative solutions to the readmissions dilemma are being tested at the local level by a variety of partnerships with hospitals and hospitalists.

For example, William C. Cook, DO, chief of hospital medicine for the Ohio Permanente Medical Group in Cleveland, is part of a community-wide quality coalition called Better Health Greater Cleveland, one of 17 such groups in the Robert Wood Johnson Foundation's Aligning Forces for Quality collaborative. The program includes 150 quality teams in 100 hospitals posting readmissions reductions and other quality metrics. Dr. Cook, who co-chairs Better Health's Steering Committee for Transitions of Care, is spearheading a transitions pilot with two local nursing homes.

"From the hospitalist perspective, our role is to make care transitions safe and predictable," Dr. Cook says. "The way I can contribute most to these transitions is by thinking ahead about what's going to happen next—and how do I prepare the patient and the next provider." One key step is taking time to complete the real-time discharge summary for each patient, he adds.

The idea, Dr. Cook explains, is to identify and communicate with collaborators across care settings so that the "coaching baton" can be passed in a manner that appears seamless to the patient.

Nearly a third of the 17 new CCTP sites participate in SHM's Project BOOST, including three hospitals in California and one each in Illinois and Pennsylvania. Project BOOST is accepting applications for its next round of sites through September.

Earlier this month CMS announced 17 additional awards under its Community-Based Care Transitions Program (CCTP), which now encompasses 200 acute-care hospitals and their hospitalists partnering with community agencies and coalitions to improve transitions of care in advance of the Oct. 1 start for excessive readmissions penalties. Innovative solutions to the readmissions dilemma are being tested at the local level by a variety of partnerships with hospitals and hospitalists.

For example, William C. Cook, DO, chief of hospital medicine for the Ohio Permanente Medical Group in Cleveland, is part of a community-wide quality coalition called Better Health Greater Cleveland, one of 17 such groups in the Robert Wood Johnson Foundation's Aligning Forces for Quality collaborative. The program includes 150 quality teams in 100 hospitals posting readmissions reductions and other quality metrics. Dr. Cook, who co-chairs Better Health's Steering Committee for Transitions of Care, is spearheading a transitions pilot with two local nursing homes.

"From the hospitalist perspective, our role is to make care transitions safe and predictable," Dr. Cook says. "The way I can contribute most to these transitions is by thinking ahead about what's going to happen next—and how do I prepare the patient and the next provider." One key step is taking time to complete the real-time discharge summary for each patient, he adds.

The idea, Dr. Cook explains, is to identify and communicate with collaborators across care settings so that the "coaching baton" can be passed in a manner that appears seamless to the patient.

Nearly a third of the 17 new CCTP sites participate in SHM's Project BOOST, including three hospitals in California and one each in Illinois and Pennsylvania. Project BOOST is accepting applications for its next round of sites through September.

Earlier this month CMS announced 17 additional awards under its Community-Based Care Transitions Program (CCTP), which now encompasses 200 acute-care hospitals and their hospitalists partnering with community agencies and coalitions to improve transitions of care in advance of the Oct. 1 start for excessive readmissions penalties. Innovative solutions to the readmissions dilemma are being tested at the local level by a variety of partnerships with hospitals and hospitalists.

For example, William C. Cook, DO, chief of hospital medicine for the Ohio Permanente Medical Group in Cleveland, is part of a community-wide quality coalition called Better Health Greater Cleveland, one of 17 such groups in the Robert Wood Johnson Foundation's Aligning Forces for Quality collaborative. The program includes 150 quality teams in 100 hospitals posting readmissions reductions and other quality metrics. Dr. Cook, who co-chairs Better Health's Steering Committee for Transitions of Care, is spearheading a transitions pilot with two local nursing homes.

"From the hospitalist perspective, our role is to make care transitions safe and predictable," Dr. Cook says. "The way I can contribute most to these transitions is by thinking ahead about what's going to happen next—and how do I prepare the patient and the next provider." One key step is taking time to complete the real-time discharge summary for each patient, he adds.

The idea, Dr. Cook explains, is to identify and communicate with collaborators across care settings so that the "coaching baton" can be passed in a manner that appears seamless to the patient.

Nearly a third of the 17 new CCTP sites participate in SHM's Project BOOST, including three hospitals in California and one each in Illinois and Pennsylvania. Project BOOST is accepting applications for its next round of sites through September.