A number of new advances have occurred in the management of chemotherapy-related nausea and vomiting (CINV). A new neurokinin-1 receptor antagonist (NK1RA), netupitant, has been combined with palonosetron in a single oral tablet for treating the effects of moderately emetogenic chemotherapy (MEC) and highly emetogenic chemotherapy (HEC). Rolapitant, another NK1RA, unlike aprepitant, has a long half-life and does not block CYP-3A4 and therefore has fewer drug interactions. Olanzapine reduces nausea more effectively than aprepitant in patients who are receiving HEC and is a better rescue antiemetic than is metoclopramide. Ginger lacks efficacy as an antiemetic agent for CINV. Although there was some evidence in a pilot study of gabapentin as an antiemetic, it was no better in reducing CINV than was placebo. Compliance to guidelines in multiple settings ranges from 50%-60% but is improved by computerized order entry of antiemetics and recommendations displayed with chemotherapy.

Click on the PDF icon at the top of this introduction to read the full article.

A number of new advances have occurred in the management of chemotherapy-related nausea and vomiting (CINV). A new neurokinin-1 receptor antagonist (NK1RA), netupitant, has been combined with palonosetron in a single oral tablet for treating the effects of moderately emetogenic chemotherapy (MEC) and highly emetogenic chemotherapy (HEC). Rolapitant, another NK1RA, unlike aprepitant, has a long half-life and does not block CYP-3A4 and therefore has fewer drug interactions. Olanzapine reduces nausea more effectively than aprepitant in patients who are receiving HEC and is a better rescue antiemetic than is metoclopramide. Ginger lacks efficacy as an antiemetic agent for CINV. Although there was some evidence in a pilot study of gabapentin as an antiemetic, it was no better in reducing CINV than was placebo. Compliance to guidelines in multiple settings ranges from 50%-60% but is improved by computerized order entry of antiemetics and recommendations displayed with chemotherapy.

Click on the PDF icon at the top of this introduction to read the full article.

A number of new advances have occurred in the management of chemotherapy-related nausea and vomiting (CINV). A new neurokinin-1 receptor antagonist (NK1RA), netupitant, has been combined with palonosetron in a single oral tablet for treating the effects of moderately emetogenic chemotherapy (MEC) and highly emetogenic chemotherapy (HEC). Rolapitant, another NK1RA, unlike aprepitant, has a long half-life and does not block CYP-3A4 and therefore has fewer drug interactions. Olanzapine reduces nausea more effectively than aprepitant in patients who are receiving HEC and is a better rescue antiemetic than is metoclopramide. Ginger lacks efficacy as an antiemetic agent for CINV. Although there was some evidence in a pilot study of gabapentin as an antiemetic, it was no better in reducing CINV than was placebo. Compliance to guidelines in multiple settings ranges from 50%-60% but is improved by computerized order entry of antiemetics and recommendations displayed with chemotherapy.

Click on the PDF icon at the top of this introduction to read the full article.

PHOENIX – National adherence to quality indicators for surgery in stage I non–small cell lung cancer is suboptimal, results from a large analysis of national data suggest.

“Compliance with such guidelines is a strong predictor of long-term survival, and vigorous efforts should be instituted at the level of national societies to improve such adherence,” researchers led by Dr. Pamela P. Samson wrote in an abstract presented at the annual meeting of the Society of Thoracic Surgeons. “National organizations, including American College of Chest Physicians, the National Comprehensive Cancer Network, and the American College of Surgeons Commission on Cancer, have recommended quality standards for surgery in early-stage non–small cell lung cancer (NSCLC). The determinants and outcomes of adherence to these guidelines for early-stage lung cancer patients are largely unknown.”

Dr. Samson, a general surgery resident at Washington University in St. Louis, and her associates used the National Cancer Data Base to evaluate data from 146,908 patients undergoing surgery for clinical stage I NSCLC between 2004 and 2013. They selected the following four quality measures for evaluation: performing an anatomical pulmonary resection, surgery within 8 weeks of diagnosis, R0 resection, and evaluation of 10 or more lymph nodes. Next, the researchers fitted multivariate models to identify variables independently associated with adherence to quality measures, and created a Cox multivariate model to evaluate long-term overall survival.

Dr. Varun Puri, senior author of the study, presented the findings at the STS meeting on behalf of Dr. Samson, and discussed the findings in a video interview. The researchers found that between 2004 and 2013, nearly 100% of patients met at least one of the four recommended criteria, 95% met two, 69% met three, and 22% met all four. Sampling of 10 or more lymph nodes was the least frequently met measure, occurring in only 31% of surgical patients. Patient factors associated with a greater likelihood of receiving all four quality measures included average income in ZIP code of at least $38,000 (odds ratio, 1.20), private insurance (OR, 1.22), or having Medicare (OR, 1.16). Institutional factors associated with a greater likelihood of meeting all four quality measures included higher-volume centers, defined as treating at least 38 cases per year (OR, 1.18), or being an academic institution (OR, 1.31).

At the same time, factors associated with a lower likelihood of recommended surgical care included increasing age (per year increase, OR, 0.99) and a higher Charlson/Deyo comorbidity score (OR, 0.90 for a score of 1 and OR, 0.82 for a score of 2 or more). The strongest determinant of long-term overall survival included pathologic upstaging (HR 1.84) and meeting all four quality indicators (HR 0.39). Every additional quality met was associated with a significant reduction in overall mortality.

“We believe this study can be a starting point to draw attention to institution- and surgeon-specific practice patterns that may vary widely,” Dr. Samson said in an interview prior to the meeting. “At our own institution, we are working to decrease time to surgery, as well as implementing quality improvement measures to increase nodal sampling rates. Improving these trends nationally must start at the local level, with a tailored approach.”

Dr. Samson is currently supported by a T32 NIH training grant for research fellows in cardiothoracic surgery. Study coauthor Dr. Bryan Meyers, has received honoraria from Varian Medical Systems and is a consultant/advisory board member of Ethicon. Senior author Dr. Varun Puri is supported by NIH career awards.

[email protected]

PHOENIX – National adherence to quality indicators for surgery in stage I non–small cell lung cancer is suboptimal, results from a large analysis of national data suggest.

“Compliance with such guidelines is a strong predictor of long-term survival, and vigorous efforts should be instituted at the level of national societies to improve such adherence,” researchers led by Dr. Pamela P. Samson wrote in an abstract presented at the annual meeting of the Society of Thoracic Surgeons. “National organizations, including American College of Chest Physicians, the National Comprehensive Cancer Network, and the American College of Surgeons Commission on Cancer, have recommended quality standards for surgery in early-stage non–small cell lung cancer (NSCLC). The determinants and outcomes of adherence to these guidelines for early-stage lung cancer patients are largely unknown.”

Dr. Samson, a general surgery resident at Washington University in St. Louis, and her associates used the National Cancer Data Base to evaluate data from 146,908 patients undergoing surgery for clinical stage I NSCLC between 2004 and 2013. They selected the following four quality measures for evaluation: performing an anatomical pulmonary resection, surgery within 8 weeks of diagnosis, R0 resection, and evaluation of 10 or more lymph nodes. Next, the researchers fitted multivariate models to identify variables independently associated with adherence to quality measures, and created a Cox multivariate model to evaluate long-term overall survival.

Dr. Varun Puri, senior author of the study, presented the findings at the STS meeting on behalf of Dr. Samson, and discussed the findings in a video interview. The researchers found that between 2004 and 2013, nearly 100% of patients met at least one of the four recommended criteria, 95% met two, 69% met three, and 22% met all four. Sampling of 10 or more lymph nodes was the least frequently met measure, occurring in only 31% of surgical patients. Patient factors associated with a greater likelihood of receiving all four quality measures included average income in ZIP code of at least $38,000 (odds ratio, 1.20), private insurance (OR, 1.22), or having Medicare (OR, 1.16). Institutional factors associated with a greater likelihood of meeting all four quality measures included higher-volume centers, defined as treating at least 38 cases per year (OR, 1.18), or being an academic institution (OR, 1.31).

At the same time, factors associated with a lower likelihood of recommended surgical care included increasing age (per year increase, OR, 0.99) and a higher Charlson/Deyo comorbidity score (OR, 0.90 for a score of 1 and OR, 0.82 for a score of 2 or more). The strongest determinant of long-term overall survival included pathologic upstaging (HR 1.84) and meeting all four quality indicators (HR 0.39). Every additional quality met was associated with a significant reduction in overall mortality.

“We believe this study can be a starting point to draw attention to institution- and surgeon-specific practice patterns that may vary widely,” Dr. Samson said in an interview prior to the meeting. “At our own institution, we are working to decrease time to surgery, as well as implementing quality improvement measures to increase nodal sampling rates. Improving these trends nationally must start at the local level, with a tailored approach.”

Dr. Samson is currently supported by a T32 NIH training grant for research fellows in cardiothoracic surgery. Study coauthor Dr. Bryan Meyers, has received honoraria from Varian Medical Systems and is a consultant/advisory board member of Ethicon. Senior author Dr. Varun Puri is supported by NIH career awards.

[email protected]

PHOENIX – National adherence to quality indicators for surgery in stage I non–small cell lung cancer is suboptimal, results from a large analysis of national data suggest.

“Compliance with such guidelines is a strong predictor of long-term survival, and vigorous efforts should be instituted at the level of national societies to improve such adherence,” researchers led by Dr. Pamela P. Samson wrote in an abstract presented at the annual meeting of the Society of Thoracic Surgeons. “National organizations, including American College of Chest Physicians, the National Comprehensive Cancer Network, and the American College of Surgeons Commission on Cancer, have recommended quality standards for surgery in early-stage non–small cell lung cancer (NSCLC). The determinants and outcomes of adherence to these guidelines for early-stage lung cancer patients are largely unknown.”

Dr. Samson, a general surgery resident at Washington University in St. Louis, and her associates used the National Cancer Data Base to evaluate data from 146,908 patients undergoing surgery for clinical stage I NSCLC between 2004 and 2013. They selected the following four quality measures for evaluation: performing an anatomical pulmonary resection, surgery within 8 weeks of diagnosis, R0 resection, and evaluation of 10 or more lymph nodes. Next, the researchers fitted multivariate models to identify variables independently associated with adherence to quality measures, and created a Cox multivariate model to evaluate long-term overall survival.

Dr. Varun Puri, senior author of the study, presented the findings at the STS meeting on behalf of Dr. Samson, and discussed the findings in a video interview. The researchers found that between 2004 and 2013, nearly 100% of patients met at least one of the four recommended criteria, 95% met two, 69% met three, and 22% met all four. Sampling of 10 or more lymph nodes was the least frequently met measure, occurring in only 31% of surgical patients. Patient factors associated with a greater likelihood of receiving all four quality measures included average income in ZIP code of at least $38,000 (odds ratio, 1.20), private insurance (OR, 1.22), or having Medicare (OR, 1.16). Institutional factors associated with a greater likelihood of meeting all four quality measures included higher-volume centers, defined as treating at least 38 cases per year (OR, 1.18), or being an academic institution (OR, 1.31).

At the same time, factors associated with a lower likelihood of recommended surgical care included increasing age (per year increase, OR, 0.99) and a higher Charlson/Deyo comorbidity score (OR, 0.90 for a score of 1 and OR, 0.82 for a score of 2 or more). The strongest determinant of long-term overall survival included pathologic upstaging (HR 1.84) and meeting all four quality indicators (HR 0.39). Every additional quality met was associated with a significant reduction in overall mortality.

“We believe this study can be a starting point to draw attention to institution- and surgeon-specific practice patterns that may vary widely,” Dr. Samson said in an interview prior to the meeting. “At our own institution, we are working to decrease time to surgery, as well as implementing quality improvement measures to increase nodal sampling rates. Improving these trends nationally must start at the local level, with a tailored approach.”

Dr. Samson is currently supported by a T32 NIH training grant for research fellows in cardiothoracic surgery. Study coauthor Dr. Bryan Meyers, has received honoraria from Varian Medical Systems and is a consultant/advisory board member of Ethicon. Senior author Dr. Varun Puri is supported by NIH career awards.

[email protected]

PHOENIX – In the clinical experience of Dr. Joshua R. Sonett, VATS thymectomy for myasthenia gravis is best performed in a bilateral thoracoscopic fashion.

In this approach, surgeons do about 95% of the operation on the left side to form a maximal thymectomy, “and finish taking out the specimen on the right side, making sure we can see both phrenic nerves in their entirety,” Dr. Sonett, chief of general thoracic surgery at Columbia University Medical Center, New York, said in a video interview at the annual meeting of the Society of Thoracic Surgeons.

Although there is no proof to date that thymectomy improves long-term outcomes for patients with myasthenia gravis, results from a large, international trial sponsored by the National Institutes of Health are expected to inform clinical practice about this topic, said Dr. Sonett, who is also director of the university’s high-risk lung assessment program.

Dr. Sonett reported having no relevant financial conflicts.

[email protected]

PHOENIX – In the clinical experience of Dr. Joshua R. Sonett, VATS thymectomy for myasthenia gravis is best performed in a bilateral thoracoscopic fashion.

In this approach, surgeons do about 95% of the operation on the left side to form a maximal thymectomy, “and finish taking out the specimen on the right side, making sure we can see both phrenic nerves in their entirety,” Dr. Sonett, chief of general thoracic surgery at Columbia University Medical Center, New York, said in a video interview at the annual meeting of the Society of Thoracic Surgeons.

Although there is no proof to date that thymectomy improves long-term outcomes for patients with myasthenia gravis, results from a large, international trial sponsored by the National Institutes of Health are expected to inform clinical practice about this topic, said Dr. Sonett, who is also director of the university’s high-risk lung assessment program.

Dr. Sonett reported having no relevant financial conflicts.

[email protected]

PHOENIX – In the clinical experience of Dr. Joshua R. Sonett, VATS thymectomy for myasthenia gravis is best performed in a bilateral thoracoscopic fashion.

In this approach, surgeons do about 95% of the operation on the left side to form a maximal thymectomy, “and finish taking out the specimen on the right side, making sure we can see both phrenic nerves in their entirety,” Dr. Sonett, chief of general thoracic surgery at Columbia University Medical Center, New York, said in a video interview at the annual meeting of the Society of Thoracic Surgeons.

Although there is no proof to date that thymectomy improves long-term outcomes for patients with myasthenia gravis, results from a large, international trial sponsored by the National Institutes of Health are expected to inform clinical practice about this topic, said Dr. Sonett, who is also director of the university’s high-risk lung assessment program.

Dr. Sonett reported having no relevant financial conflicts.

[email protected]

Editor’s note: “Everything We Say and Do” is an informational series developed by SHM’s Patient Experience Committee to provide readers with thoughtful and actionable communication tactics that have great potential to positively impact patients’ experience of care. Each article will focus on how the contributor applies one ormore of the “key communication” tactics in practice to maintain provider accountability for “Everything we say and do that affects our patients’ thoughts, feelings and well-being.”

As providers, how do we define the patient experience? Over the past year, I have had the pleasure of working with a dedicated group of 15 fellow members on the newly formed SHM Patient Experience Committee. One of our first goals was to define the patient experience in a way that acknowledges our role and its potential impact on patients as emotional beings and not just vessels for their disease.

To this end, we define the patient experience as “everything we say and do that affects our patients’ thoughts, feelings, and well-being.

Although it’s true that patients bring with them their own history and narrative that contribute to their experience, we cannot change that. We can only adjust our own behaviors and actions when we seek to elicit or respond to patients’ concerns and goals.

And although “everything we say and do” is inclusive of providing the most effective and evidence-based medical care at all times, we believe that accurate clinical decision making absolutely must be accompanied by superior communication. By offering clear explanations, listening compassionately, and acknowledging patients’ predicaments with empathy and caring statements, we can restore a degree of humanity to our care that will allow patients to trust that we have their best interests in mind at all times. This is our role in improving the patient experience.

Beginning next month, members of the Patient Experience Committee will be sharing key communication skills and interventions that each of us believes to be important and effective. Each member will share what they do, why they do it, and how it can be done effectively. The items we’ll be focusing on will be taken from the “Core Principles” and “Key Communications,” as compiled by the committee (see Table 1, below). Some have evidence to back them up. Some are common sense. All of them are simply the right thing to do.

We hope you’ll reflect on “everything we say and do” each month as well as share it with your colleagues and teams. And we need look no further for a winning argument to focus on the patient experience than Sir William Osler and one of his most famous quotes: “The good physician treats the disease; the great physician treats the patient who has the disease.”

We’re going for great. Are you with us? TH

Dr. Rudolph is vice president of physician development and patient experience for Tacoma, Wash.–based Sound Physicians. He is chair of SHM’s Patient Experience Committee.

Table 1.

Editor’s note: “Everything We Say and Do” is an informational series developed by SHM’s Patient Experience Committee to provide readers with thoughtful and actionable communication tactics that have great potential to positively impact patients’ experience of care. Each article will focus on how the contributor applies one ormore of the “key communication” tactics in practice to maintain provider accountability for “Everything we say and do that affects our patients’ thoughts, feelings and well-being.”

As providers, how do we define the patient experience? Over the past year, I have had the pleasure of working with a dedicated group of 15 fellow members on the newly formed SHM Patient Experience Committee. One of our first goals was to define the patient experience in a way that acknowledges our role and its potential impact on patients as emotional beings and not just vessels for their disease.

To this end, we define the patient experience as “everything we say and do that affects our patients’ thoughts, feelings, and well-being.

Although it’s true that patients bring with them their own history and narrative that contribute to their experience, we cannot change that. We can only adjust our own behaviors and actions when we seek to elicit or respond to patients’ concerns and goals.

And although “everything we say and do” is inclusive of providing the most effective and evidence-based medical care at all times, we believe that accurate clinical decision making absolutely must be accompanied by superior communication. By offering clear explanations, listening compassionately, and acknowledging patients’ predicaments with empathy and caring statements, we can restore a degree of humanity to our care that will allow patients to trust that we have their best interests in mind at all times. This is our role in improving the patient experience.

Beginning next month, members of the Patient Experience Committee will be sharing key communication skills and interventions that each of us believes to be important and effective. Each member will share what they do, why they do it, and how it can be done effectively. The items we’ll be focusing on will be taken from the “Core Principles” and “Key Communications,” as compiled by the committee (see Table 1, below). Some have evidence to back them up. Some are common sense. All of them are simply the right thing to do.

We hope you’ll reflect on “everything we say and do” each month as well as share it with your colleagues and teams. And we need look no further for a winning argument to focus on the patient experience than Sir William Osler and one of his most famous quotes: “The good physician treats the disease; the great physician treats the patient who has the disease.”

We’re going for great. Are you with us? TH

Dr. Rudolph is vice president of physician development and patient experience for Tacoma, Wash.–based Sound Physicians. He is chair of SHM’s Patient Experience Committee.

Table 1.

Editor’s note: “Everything We Say and Do” is an informational series developed by SHM’s Patient Experience Committee to provide readers with thoughtful and actionable communication tactics that have great potential to positively impact patients’ experience of care. Each article will focus on how the contributor applies one ormore of the “key communication” tactics in practice to maintain provider accountability for “Everything we say and do that affects our patients’ thoughts, feelings and well-being.”

As providers, how do we define the patient experience? Over the past year, I have had the pleasure of working with a dedicated group of 15 fellow members on the newly formed SHM Patient Experience Committee. One of our first goals was to define the patient experience in a way that acknowledges our role and its potential impact on patients as emotional beings and not just vessels for their disease.

To this end, we define the patient experience as “everything we say and do that affects our patients’ thoughts, feelings, and well-being.

Although it’s true that patients bring with them their own history and narrative that contribute to their experience, we cannot change that. We can only adjust our own behaviors and actions when we seek to elicit or respond to patients’ concerns and goals.

And although “everything we say and do” is inclusive of providing the most effective and evidence-based medical care at all times, we believe that accurate clinical decision making absolutely must be accompanied by superior communication. By offering clear explanations, listening compassionately, and acknowledging patients’ predicaments with empathy and caring statements, we can restore a degree of humanity to our care that will allow patients to trust that we have their best interests in mind at all times. This is our role in improving the patient experience.

Beginning next month, members of the Patient Experience Committee will be sharing key communication skills and interventions that each of us believes to be important and effective. Each member will share what they do, why they do it, and how it can be done effectively. The items we’ll be focusing on will be taken from the “Core Principles” and “Key Communications,” as compiled by the committee (see Table 1, below). Some have evidence to back them up. Some are common sense. All of them are simply the right thing to do.

We hope you’ll reflect on “everything we say and do” each month as well as share it with your colleagues and teams. And we need look no further for a winning argument to focus on the patient experience than Sir William Osler and one of his most famous quotes: “The good physician treats the disease; the great physician treats the patient who has the disease.”

We’re going for great. Are you with us? TH

Dr. Rudolph is vice president of physician development and patient experience for Tacoma, Wash.–based Sound Physicians. He is chair of SHM’s Patient Experience Committee.

Table 1.

Two adequate views of the lower cervical vertebrae are necessary to confirm the 3-dimensional location of any hardware placed during cervical spine fusion. Visualizing the lower cervical vertebrae in 2 planes intraoperatively is often a challenge because the shoulders obstruct the lateral view.¹ Techniques have been described to improve lateral visualization, including gentle traction of the arms via wrist restraints or taping the shoulders down inferiorly.^2,3 These techniques have their inadequacies, including an association with peripheral nerve injury and brachial plexopathy.⁴ In patients with stout necks, these methods may still be insufficient to achieve adequate visualization of the lower cervical vertebrae.

Invasive techniques to improve visualization have also been described. In 1 study, exposure had to be extended cephalad to allow for manual counting of cervical vertebrae when the mid- to lower cervical vertebrae had to be identified in a morbidly obese patient.⁵ More invasive spine procedures are associated with higher rates of complications, increased blood loss, more soft-tissue trauma, and longer hospital stays.⁶ We present a view 30º oblique from horizontal and 30º cephalad from neutral as a variation of the lateral radiograph that improves visualization of the mid- to lower cervical vertebrae. The authors have obtained the patients’ informed written consent for print and electronic publication of these case reports.

Technique

We used either the Smith-Robinson or Cloward approach to the anterior spine. Both techniques use the avascular plane between the medially located esophagus and trachea and the lateral sternocleidomastoid and carotid sheath to approach the anterior cervical spine. Once adequate exposure was achieved, standard anteroposterior and lateral radiographs were obtained to confirm the correct vertebral level. Gentle caudal traction was applied to the patient’s wrist straps, and when visualization continued to be compromised, a view 30º oblique from horizontal and 30º cephalad from neutral was obtained (Figure 1).

Case Series

Case 1

A 54-year-old man with a body mass index (BMI) of 50 presented with neck and bilateral arm pain, with left greater than right radicular symptoms in the C6 and C7 distribution. Magnetic resonance imaging (MRI) showed disc herniations at C5-C6 and C6-C7 with spinal cord signal changes, and he underwent a C5-C6 and C6-C7 anterior cervical discectomy and fusion. Initial localization was determined using a lateral radiograph and vertebral needle. During hardware placement, anteroposterior and lateral fluoroscopic radiographs confirmed adequate placement of the superior screw, but visualization of the inferior portion of the plate and inferior screw was challenging (Figure 2). Our oblique 30º–30º view provided better visualization of the plate and screws in the lower cervical vertebrae than lateral imaging, and allowed confirmation that the hardware was positioned correctly (Figure 3). It took 1 attempt to achieve adequate visualization with the 30º–30º view.

Postoperatively, the patient’s radiculopathy and motor weakness improved. Radiographs confirmed adequate hardware placement, and he was discharged on postoperative day 1 (Figure 4). Imaging at the patient’s 6-week follow-up confirmed adequate fusion from C5-C7, anatomically aligned facet joints, and no hardware failure. The patient’s Neck Disability Index was 31/50 preoperatively and 26/50 at this visit.

Case 2

A 51-year-old man with a BMI of 29 presented with a long-standing history of neck pain and bilateral arm pain left greater than right in the C6 and C7 dermomyotome. MRI showed a broad-based disc herniation with foraminal narrowing at C5-C6 and C6-C7, and the patient underwent a 2-level anterior cervical discectomy and fusion. This patient had pronounced neck musculature, and a deeper than normal incision was required.

Intraoperative lateral fluoroscopy was obtained to confirm the C5-C6 and C6-C7 level prior to discectomy. The musculature of the patient’s neck and shoulder made visualization of the C6-C7 disc space difficult on the lateral radiograph (Figure 5). One attempt was required to obtain the 30º–30º oblique view, which was used to ensure correct placement of the screws and plate (Figure 6).

Postoperatively, the patient’s pain had improved, and radiographs confirmed adequate hardware placement. He was discharged 1 day after surgery (Figure 7). Imaging at the patient’s 6-week follow-up confirmed adequate fusion from C5-C7, stable disc spaces, and anatomically aligned facet joints. His Neck Disability Index was 34/50 preoperatively and 32/50 at 2-week follow-up.

Discussion

The aim of this study was to describe an alternative to the lateral radiograph for imaging the cervical spine in patients with challenging anatomy or in procedures involving hardware placement at the lower cervical vertebrae. Techniques have been developed to assist with improved lateral visualization, including gentle traction of the arms via wrist restraints or taping the shoulders down inferiorly.2,3 However, visualization in 2 planes continues to be a challenge in a subset of patients. It is particularly difficult to obtain adequate lateral radiographs of the cervical spine in patients with stout necks.³ In patients with stout necks, there is more obstruction of the radiography path through the cervical spine. This leads to imaging that is unclear or may fail to show the mid- to lower cervical spine. The extent to which one should rely on the 30º–30º oblique technique for adequate visualization of the cervical spine depends on the anatomy of a particular patient. Historically, it is more challenging to obtain satisfactory lateral radiographs in patients with stout necks,³ and these patients have benefited the most from using the 30º–30º degree oblique view.

Lack of visualization can lead to aborted surgeries or, potentially, surgery at the wrong level.³ A 2008 American Academy of Neurological Surgeons survey indicated that 50% of spine surgeons had performed a wrong-level surgery at least once in their career, and the cervical spine accounted for 21% of all incorrect-level spine surgeries.⁷ Intraoperative factors reported during cases of wrong-level spinal surgeries included misinterpretation of intraoperative imaging, no intraoperative imaging, and unusual anatomy or physical characteristics.⁸ Such complications can lead to revision surgery and other significant morbidities for the patient.

In most patients, fluoroscopy allows confirmation of the correct level before disc incision.³ However, operating at a lower cervical level in a patient with a short neck or prominent shoulders poses a significant problem.³ A case report from Singh and colleagues⁹ described a modified intraoperative fluoroscopic view for spinal level localization at cervicothoracic levels. Their method focuses on identifying the bony lamina and using them as landmarks to count spinal levels, whereas our 30º–30º oblique image is useful for confirmation of adequate hardware placement during anterior cervical spinal fusions. Often, the initial localization of cervical vertebral levels can be achieved with a standard lateral radiograph. We recognized the utility of the 30º–30º oblique view when we were attempting to visualize the inferior aspect of the plate and inferior screw placement.

In patients with stout necks, a lateral radiograph may show only visualization down to C4 or C5.³ Even with applying traction to the arms or taping the shoulders down, it can be impossible to visualize C6, C7, or T1 because the shoulder bones and muscles obstruct the image.³ Using a 30º–30º oblique view, we were able to obtain adequate visualization and assess the accurate placement of hardware.

Conclusion

A 30º oblique view from horizontal and 30º cephalad from neutral radiograph can be used intraoperatively in patients with challenging anatomy to identify placement of hardware at the correct vertebral level in the lower cervical spine. It is a noninvasive technique that can help reduce the risk of wrong-site surgeries without prolonging operation time. This technique describes an alternative to the lateral radiograph and provides a solution to the difficult problem of intraoperative imaging of the mid- to lower cervical spine in 2 adequate planes.

Two adequate views of the lower cervical vertebrae are necessary to confirm the 3-dimensional location of any hardware placed during cervical spine fusion. Visualizing the lower cervical vertebrae in 2 planes intraoperatively is often a challenge because the shoulders obstruct the lateral view.¹ Techniques have been described to improve lateral visualization, including gentle traction of the arms via wrist restraints or taping the shoulders down inferiorly.^2,3 These techniques have their inadequacies, including an association with peripheral nerve injury and brachial plexopathy.⁴ In patients with stout necks, these methods may still be insufficient to achieve adequate visualization of the lower cervical vertebrae.

Invasive techniques to improve visualization have also been described. In 1 study, exposure had to be extended cephalad to allow for manual counting of cervical vertebrae when the mid- to lower cervical vertebrae had to be identified in a morbidly obese patient.⁵ More invasive spine procedures are associated with higher rates of complications, increased blood loss, more soft-tissue trauma, and longer hospital stays.⁶ We present a view 30º oblique from horizontal and 30º cephalad from neutral as a variation of the lateral radiograph that improves visualization of the mid- to lower cervical vertebrae. The authors have obtained the patients’ informed written consent for print and electronic publication of these case reports.

Technique

We used either the Smith-Robinson or Cloward approach to the anterior spine. Both techniques use the avascular plane between the medially located esophagus and trachea and the lateral sternocleidomastoid and carotid sheath to approach the anterior cervical spine. Once adequate exposure was achieved, standard anteroposterior and lateral radiographs were obtained to confirm the correct vertebral level. Gentle caudal traction was applied to the patient’s wrist straps, and when visualization continued to be compromised, a view 30º oblique from horizontal and 30º cephalad from neutral was obtained (Figure 1).

Case Series

Case 1

A 54-year-old man with a body mass index (BMI) of 50 presented with neck and bilateral arm pain, with left greater than right radicular symptoms in the C6 and C7 distribution. Magnetic resonance imaging (MRI) showed disc herniations at C5-C6 and C6-C7 with spinal cord signal changes, and he underwent a C5-C6 and C6-C7 anterior cervical discectomy and fusion. Initial localization was determined using a lateral radiograph and vertebral needle. During hardware placement, anteroposterior and lateral fluoroscopic radiographs confirmed adequate placement of the superior screw, but visualization of the inferior portion of the plate and inferior screw was challenging (Figure 2). Our oblique 30º–30º view provided better visualization of the plate and screws in the lower cervical vertebrae than lateral imaging, and allowed confirmation that the hardware was positioned correctly (Figure 3). It took 1 attempt to achieve adequate visualization with the 30º–30º view.

Postoperatively, the patient’s radiculopathy and motor weakness improved. Radiographs confirmed adequate hardware placement, and he was discharged on postoperative day 1 (Figure 4). Imaging at the patient’s 6-week follow-up confirmed adequate fusion from C5-C7, anatomically aligned facet joints, and no hardware failure. The patient’s Neck Disability Index was 31/50 preoperatively and 26/50 at this visit.

Case 2

A 51-year-old man with a BMI of 29 presented with a long-standing history of neck pain and bilateral arm pain left greater than right in the C6 and C7 dermomyotome. MRI showed a broad-based disc herniation with foraminal narrowing at C5-C6 and C6-C7, and the patient underwent a 2-level anterior cervical discectomy and fusion. This patient had pronounced neck musculature, and a deeper than normal incision was required.

Intraoperative lateral fluoroscopy was obtained to confirm the C5-C6 and C6-C7 level prior to discectomy. The musculature of the patient’s neck and shoulder made visualization of the C6-C7 disc space difficult on the lateral radiograph (Figure 5). One attempt was required to obtain the 30º–30º oblique view, which was used to ensure correct placement of the screws and plate (Figure 6).

Postoperatively, the patient’s pain had improved, and radiographs confirmed adequate hardware placement. He was discharged 1 day after surgery (Figure 7). Imaging at the patient’s 6-week follow-up confirmed adequate fusion from C5-C7, stable disc spaces, and anatomically aligned facet joints. His Neck Disability Index was 34/50 preoperatively and 32/50 at 2-week follow-up.

Discussion

The aim of this study was to describe an alternative to the lateral radiograph for imaging the cervical spine in patients with challenging anatomy or in procedures involving hardware placement at the lower cervical vertebrae. Techniques have been developed to assist with improved lateral visualization, including gentle traction of the arms via wrist restraints or taping the shoulders down inferiorly.2,3 However, visualization in 2 planes continues to be a challenge in a subset of patients. It is particularly difficult to obtain adequate lateral radiographs of the cervical spine in patients with stout necks.³ In patients with stout necks, there is more obstruction of the radiography path through the cervical spine. This leads to imaging that is unclear or may fail to show the mid- to lower cervical spine. The extent to which one should rely on the 30º–30º oblique technique for adequate visualization of the cervical spine depends on the anatomy of a particular patient. Historically, it is more challenging to obtain satisfactory lateral radiographs in patients with stout necks,³ and these patients have benefited the most from using the 30º–30º degree oblique view.

Lack of visualization can lead to aborted surgeries or, potentially, surgery at the wrong level.³ A 2008 American Academy of Neurological Surgeons survey indicated that 50% of spine surgeons had performed a wrong-level surgery at least once in their career, and the cervical spine accounted for 21% of all incorrect-level spine surgeries.⁷ Intraoperative factors reported during cases of wrong-level spinal surgeries included misinterpretation of intraoperative imaging, no intraoperative imaging, and unusual anatomy or physical characteristics.⁸ Such complications can lead to revision surgery and other significant morbidities for the patient.

In most patients, fluoroscopy allows confirmation of the correct level before disc incision.³ However, operating at a lower cervical level in a patient with a short neck or prominent shoulders poses a significant problem.³ A case report from Singh and colleagues⁹ described a modified intraoperative fluoroscopic view for spinal level localization at cervicothoracic levels. Their method focuses on identifying the bony lamina and using them as landmarks to count spinal levels, whereas our 30º–30º oblique image is useful for confirmation of adequate hardware placement during anterior cervical spinal fusions. Often, the initial localization of cervical vertebral levels can be achieved with a standard lateral radiograph. We recognized the utility of the 30º–30º oblique view when we were attempting to visualize the inferior aspect of the plate and inferior screw placement.

In patients with stout necks, a lateral radiograph may show only visualization down to C4 or C5.³ Even with applying traction to the arms or taping the shoulders down, it can be impossible to visualize C6, C7, or T1 because the shoulder bones and muscles obstruct the image.³ Using a 30º–30º oblique view, we were able to obtain adequate visualization and assess the accurate placement of hardware.

Conclusion

A 30º oblique view from horizontal and 30º cephalad from neutral radiograph can be used intraoperatively in patients with challenging anatomy to identify placement of hardware at the correct vertebral level in the lower cervical spine. It is a noninvasive technique that can help reduce the risk of wrong-site surgeries without prolonging operation time. This technique describes an alternative to the lateral radiograph and provides a solution to the difficult problem of intraoperative imaging of the mid- to lower cervical spine in 2 adequate planes.

Two adequate views of the lower cervical vertebrae are necessary to confirm the 3-dimensional location of any hardware placed during cervical spine fusion. Visualizing the lower cervical vertebrae in 2 planes intraoperatively is often a challenge because the shoulders obstruct the lateral view.¹ Techniques have been described to improve lateral visualization, including gentle traction of the arms via wrist restraints or taping the shoulders down inferiorly.^2,3 These techniques have their inadequacies, including an association with peripheral nerve injury and brachial plexopathy.⁴ In patients with stout necks, these methods may still be insufficient to achieve adequate visualization of the lower cervical vertebrae.

Invasive techniques to improve visualization have also been described. In 1 study, exposure had to be extended cephalad to allow for manual counting of cervical vertebrae when the mid- to lower cervical vertebrae had to be identified in a morbidly obese patient.⁵ More invasive spine procedures are associated with higher rates of complications, increased blood loss, more soft-tissue trauma, and longer hospital stays.⁶ We present a view 30º oblique from horizontal and 30º cephalad from neutral as a variation of the lateral radiograph that improves visualization of the mid- to lower cervical vertebrae. The authors have obtained the patients’ informed written consent for print and electronic publication of these case reports.

Technique

We used either the Smith-Robinson or Cloward approach to the anterior spine. Both techniques use the avascular plane between the medially located esophagus and trachea and the lateral sternocleidomastoid and carotid sheath to approach the anterior cervical spine. Once adequate exposure was achieved, standard anteroposterior and lateral radiographs were obtained to confirm the correct vertebral level. Gentle caudal traction was applied to the patient’s wrist straps, and when visualization continued to be compromised, a view 30º oblique from horizontal and 30º cephalad from neutral was obtained (Figure 1).

Case Series

Case 1

A 54-year-old man with a body mass index (BMI) of 50 presented with neck and bilateral arm pain, with left greater than right radicular symptoms in the C6 and C7 distribution. Magnetic resonance imaging (MRI) showed disc herniations at C5-C6 and C6-C7 with spinal cord signal changes, and he underwent a C5-C6 and C6-C7 anterior cervical discectomy and fusion. Initial localization was determined using a lateral radiograph and vertebral needle. During hardware placement, anteroposterior and lateral fluoroscopic radiographs confirmed adequate placement of the superior screw, but visualization of the inferior portion of the plate and inferior screw was challenging (Figure 2). Our oblique 30º–30º view provided better visualization of the plate and screws in the lower cervical vertebrae than lateral imaging, and allowed confirmation that the hardware was positioned correctly (Figure 3). It took 1 attempt to achieve adequate visualization with the 30º–30º view.

Postoperatively, the patient’s radiculopathy and motor weakness improved. Radiographs confirmed adequate hardware placement, and he was discharged on postoperative day 1 (Figure 4). Imaging at the patient’s 6-week follow-up confirmed adequate fusion from C5-C7, anatomically aligned facet joints, and no hardware failure. The patient’s Neck Disability Index was 31/50 preoperatively and 26/50 at this visit.

Case 2

A 51-year-old man with a BMI of 29 presented with a long-standing history of neck pain and bilateral arm pain left greater than right in the C6 and C7 dermomyotome. MRI showed a broad-based disc herniation with foraminal narrowing at C5-C6 and C6-C7, and the patient underwent a 2-level anterior cervical discectomy and fusion. This patient had pronounced neck musculature, and a deeper than normal incision was required.

Intraoperative lateral fluoroscopy was obtained to confirm the C5-C6 and C6-C7 level prior to discectomy. The musculature of the patient’s neck and shoulder made visualization of the C6-C7 disc space difficult on the lateral radiograph (Figure 5). One attempt was required to obtain the 30º–30º oblique view, which was used to ensure correct placement of the screws and plate (Figure 6).

Postoperatively, the patient’s pain had improved, and radiographs confirmed adequate hardware placement. He was discharged 1 day after surgery (Figure 7). Imaging at the patient’s 6-week follow-up confirmed adequate fusion from C5-C7, stable disc spaces, and anatomically aligned facet joints. His Neck Disability Index was 34/50 preoperatively and 32/50 at 2-week follow-up.

Discussion

The aim of this study was to describe an alternative to the lateral radiograph for imaging the cervical spine in patients with challenging anatomy or in procedures involving hardware placement at the lower cervical vertebrae. Techniques have been developed to assist with improved lateral visualization, including gentle traction of the arms via wrist restraints or taping the shoulders down inferiorly.2,3 However, visualization in 2 planes continues to be a challenge in a subset of patients. It is particularly difficult to obtain adequate lateral radiographs of the cervical spine in patients with stout necks.³ In patients with stout necks, there is more obstruction of the radiography path through the cervical spine. This leads to imaging that is unclear or may fail to show the mid- to lower cervical spine. The extent to which one should rely on the 30º–30º oblique technique for adequate visualization of the cervical spine depends on the anatomy of a particular patient. Historically, it is more challenging to obtain satisfactory lateral radiographs in patients with stout necks,³ and these patients have benefited the most from using the 30º–30º degree oblique view.

Lack of visualization can lead to aborted surgeries or, potentially, surgery at the wrong level.³ A 2008 American Academy of Neurological Surgeons survey indicated that 50% of spine surgeons had performed a wrong-level surgery at least once in their career, and the cervical spine accounted for 21% of all incorrect-level spine surgeries.⁷ Intraoperative factors reported during cases of wrong-level spinal surgeries included misinterpretation of intraoperative imaging, no intraoperative imaging, and unusual anatomy or physical characteristics.⁸ Such complications can lead to revision surgery and other significant morbidities for the patient.

In most patients, fluoroscopy allows confirmation of the correct level before disc incision.³ However, operating at a lower cervical level in a patient with a short neck or prominent shoulders poses a significant problem.³ A case report from Singh and colleagues⁹ described a modified intraoperative fluoroscopic view for spinal level localization at cervicothoracic levels. Their method focuses on identifying the bony lamina and using them as landmarks to count spinal levels, whereas our 30º–30º oblique image is useful for confirmation of adequate hardware placement during anterior cervical spinal fusions. Often, the initial localization of cervical vertebral levels can be achieved with a standard lateral radiograph. We recognized the utility of the 30º–30º oblique view when we were attempting to visualize the inferior aspect of the plate and inferior screw placement.

In patients with stout necks, a lateral radiograph may show only visualization down to C4 or C5.³ Even with applying traction to the arms or taping the shoulders down, it can be impossible to visualize C6, C7, or T1 because the shoulder bones and muscles obstruct the image.³ Using a 30º–30º oblique view, we were able to obtain adequate visualization and assess the accurate placement of hardware.

Conclusion

A 30º oblique view from horizontal and 30º cephalad from neutral radiograph can be used intraoperatively in patients with challenging anatomy to identify placement of hardware at the correct vertebral level in the lower cervical spine. It is a noninvasive technique that can help reduce the risk of wrong-site surgeries without prolonging operation time. This technique describes an alternative to the lateral radiograph and provides a solution to the difficult problem of intraoperative imaging of the mid- to lower cervical spine in 2 adequate planes.

Thrombus

Image by Kevin MacKenzie

The International Society on Thrombosis and Haemostasis (ISTH) has announced its new international clinical core curriculum on thrombosis and hemostasis.

It is the first framework of its kind to define the minimum standards for a medical doctor to attain a level of proficiency to practice independently as a specialist in the field.

The core curriculum appears in the January 2016 issue of the Journal of Thrombosis and Haemostasis.

“Internationally, there is wide variation in how clinicians who work in thrombosis and hemostasis reach their final destination as recognized specialists,” said Claire McLintock, MD, of Auckland City Hospital in New Zealand.

“The ISTH clinical core curriculum serves to provide a framework for training of specialists in this field and to promote harmonization of training internationally.”

Dr McLintock noted that, prior to the development of the ISTH core curriculum, there was no international consensus on what constituted the requirements for a specialist in thrombosis and hemostasis in terms of clinical competencies.

In 2013, ISTH identified the need for an international clinical core curriculum and developed a working group consisting of specialists from around the world to address and draft a list of competencies.

ISTH members and the global thrombosis and hemostasis community were surveyed to rate the importance of the proposed competencies. The survey garnered more than 640 responses with broad geographical representation, which determined the ultimate framework for the new curriculum.

“We are pleased to release this exciting new resource for the global thrombosis and hemostasis community,” said Nigel Key, MD, of the UNC Hemophilia and Thrombosis Center in Chapel Hill, North Carolina.

“Our intent is for the core curriculum to serve as a common reference point for national and regional thrombosis and hemostasis societies to create or revise their own clinical training programs. Additionally, it can potentially be used as a framework for continuous professional development, maintenance of competence, and to inform future ISTH educational offerings.”

Thrombus

Image by Kevin MacKenzie

The International Society on Thrombosis and Haemostasis (ISTH) has announced its new international clinical core curriculum on thrombosis and hemostasis.

It is the first framework of its kind to define the minimum standards for a medical doctor to attain a level of proficiency to practice independently as a specialist in the field.

The core curriculum appears in the January 2016 issue of the Journal of Thrombosis and Haemostasis.

“Internationally, there is wide variation in how clinicians who work in thrombosis and hemostasis reach their final destination as recognized specialists,” said Claire McLintock, MD, of Auckland City Hospital in New Zealand.

“The ISTH clinical core curriculum serves to provide a framework for training of specialists in this field and to promote harmonization of training internationally.”

Dr McLintock noted that, prior to the development of the ISTH core curriculum, there was no international consensus on what constituted the requirements for a specialist in thrombosis and hemostasis in terms of clinical competencies.

In 2013, ISTH identified the need for an international clinical core curriculum and developed a working group consisting of specialists from around the world to address and draft a list of competencies.

ISTH members and the global thrombosis and hemostasis community were surveyed to rate the importance of the proposed competencies. The survey garnered more than 640 responses with broad geographical representation, which determined the ultimate framework for the new curriculum.

“We are pleased to release this exciting new resource for the global thrombosis and hemostasis community,” said Nigel Key, MD, of the UNC Hemophilia and Thrombosis Center in Chapel Hill, North Carolina.

“Our intent is for the core curriculum to serve as a common reference point for national and regional thrombosis and hemostasis societies to create or revise their own clinical training programs. Additionally, it can potentially be used as a framework for continuous professional development, maintenance of competence, and to inform future ISTH educational offerings.”

Thrombus

Image by Kevin MacKenzie

The International Society on Thrombosis and Haemostasis (ISTH) has announced its new international clinical core curriculum on thrombosis and hemostasis.

It is the first framework of its kind to define the minimum standards for a medical doctor to attain a level of proficiency to practice independently as a specialist in the field.

The core curriculum appears in the January 2016 issue of the Journal of Thrombosis and Haemostasis.

“Internationally, there is wide variation in how clinicians who work in thrombosis and hemostasis reach their final destination as recognized specialists,” said Claire McLintock, MD, of Auckland City Hospital in New Zealand.

“The ISTH clinical core curriculum serves to provide a framework for training of specialists in this field and to promote harmonization of training internationally.”

Dr McLintock noted that, prior to the development of the ISTH core curriculum, there was no international consensus on what constituted the requirements for a specialist in thrombosis and hemostasis in terms of clinical competencies.

In 2013, ISTH identified the need for an international clinical core curriculum and developed a working group consisting of specialists from around the world to address and draft a list of competencies.

ISTH members and the global thrombosis and hemostasis community were surveyed to rate the importance of the proposed competencies. The survey garnered more than 640 responses with broad geographical representation, which determined the ultimate framework for the new curriculum.

“We are pleased to release this exciting new resource for the global thrombosis and hemostasis community,” said Nigel Key, MD, of the UNC Hemophilia and Thrombosis Center in Chapel Hill, North Carolina.

“Our intent is for the core curriculum to serve as a common reference point for national and regional thrombosis and hemostasis societies to create or revise their own clinical training programs. Additionally, it can potentially be used as a framework for continuous professional development, maintenance of competence, and to inform future ISTH educational offerings.”

Blood sample collection

Photo by Juan D. Alfonso

NHS Blood and Transplant (NHSBT) has announced an initiative to provide more detailed blood-group typing for patients with hemoglobinopathies, with the goal of enabling better-matched and potentially safer transfusions.

The typing will detect Rh variant blood groups, which need to be considered when planning transfusions.

Previously, typing to this level was only possible through reference laboratories using complex genotyping methods.

NHSBT is offering the testing at no extra cost to hospitals in England until the end of June 2016.

The initiative involves routinely testing for the RHD and RHCE variants most commonly found in patients with hemoglobinopathies. NHSBT will also test genes for the blood groups K, k, Kpa, Kpb, Jsa, Jsb, Jka, Jkb, Fya, Fyb, Fy (GATA), M, N, S, s, U, Doa, and Dob.

Unlike older methods, this testing can be performed in patients who have recently received blood.

NHSBT said this initiative will enable the creation of a database of genotyped blood details for patients with hemoglobinopathies.

Extended blood type information and fast access to the database could potentially enable safer blood transfusions for these patients, who may need numerous transfusions during their lifetime and may move between hospitals.

NHSBT said it has received more than 2500 blood samples thus far. The results are processed centrally by NHSBT at the International Blood Group Reference Laboratory in Filton and are securely stored.

Patients’ test results will be accessible to the teams involved in the patients’ care.

“Patients taking part can now potentially receive more finely matched blood if we know not just their blood group but whether they have a variant Rh type,” said Sara Trompeter, MB ChB, a consultant hematologist for NHSBT.

“And there will also be greater safety and likelihood of getting matched blood in an emergency, as their records will be held centrally and can be accessed by blood banks in local hospitals. We would urge all patients with hemoglobin disorders such as sickle cell disease or thalassemia to speak to their medical or nursing team about providing a blood sample to NHS Blood and Transplant via their local transfusion laboratories to be genotyped.”

Additional information on this initiative can be found at www.nhsbt.nhs.uk/extendedbloodgrouptesting.

Blood sample collection

Photo by Juan D. Alfonso

NHS Blood and Transplant (NHSBT) has announced an initiative to provide more detailed blood-group typing for patients with hemoglobinopathies, with the goal of enabling better-matched and potentially safer transfusions.

The typing will detect Rh variant blood groups, which need to be considered when planning transfusions.

Previously, typing to this level was only possible through reference laboratories using complex genotyping methods.

NHSBT is offering the testing at no extra cost to hospitals in England until the end of June 2016.

The initiative involves routinely testing for the RHD and RHCE variants most commonly found in patients with hemoglobinopathies. NHSBT will also test genes for the blood groups K, k, Kpa, Kpb, Jsa, Jsb, Jka, Jkb, Fya, Fyb, Fy (GATA), M, N, S, s, U, Doa, and Dob.

Unlike older methods, this testing can be performed in patients who have recently received blood.

NHSBT said this initiative will enable the creation of a database of genotyped blood details for patients with hemoglobinopathies.

Extended blood type information and fast access to the database could potentially enable safer blood transfusions for these patients, who may need numerous transfusions during their lifetime and may move between hospitals.

NHSBT said it has received more than 2500 blood samples thus far. The results are processed centrally by NHSBT at the International Blood Group Reference Laboratory in Filton and are securely stored.

Patients’ test results will be accessible to the teams involved in the patients’ care.

“Patients taking part can now potentially receive more finely matched blood if we know not just their blood group but whether they have a variant Rh type,” said Sara Trompeter, MB ChB, a consultant hematologist for NHSBT.

“And there will also be greater safety and likelihood of getting matched blood in an emergency, as their records will be held centrally and can be accessed by blood banks in local hospitals. We would urge all patients with hemoglobin disorders such as sickle cell disease or thalassemia to speak to their medical or nursing team about providing a blood sample to NHS Blood and Transplant via their local transfusion laboratories to be genotyped.”

Additional information on this initiative can be found at www.nhsbt.nhs.uk/extendedbloodgrouptesting.

Blood sample collection

Photo by Juan D. Alfonso

NHS Blood and Transplant (NHSBT) has announced an initiative to provide more detailed blood-group typing for patients with hemoglobinopathies, with the goal of enabling better-matched and potentially safer transfusions.

The typing will detect Rh variant blood groups, which need to be considered when planning transfusions.

Previously, typing to this level was only possible through reference laboratories using complex genotyping methods.

NHSBT is offering the testing at no extra cost to hospitals in England until the end of June 2016.

The initiative involves routinely testing for the RHD and RHCE variants most commonly found in patients with hemoglobinopathies. NHSBT will also test genes for the blood groups K, k, Kpa, Kpb, Jsa, Jsb, Jka, Jkb, Fya, Fyb, Fy (GATA), M, N, S, s, U, Doa, and Dob.

Unlike older methods, this testing can be performed in patients who have recently received blood.

NHSBT said this initiative will enable the creation of a database of genotyped blood details for patients with hemoglobinopathies.

Extended blood type information and fast access to the database could potentially enable safer blood transfusions for these patients, who may need numerous transfusions during their lifetime and may move between hospitals.

NHSBT said it has received more than 2500 blood samples thus far. The results are processed centrally by NHSBT at the International Blood Group Reference Laboratory in Filton and are securely stored.

Patients’ test results will be accessible to the teams involved in the patients’ care.

“Patients taking part can now potentially receive more finely matched blood if we know not just their blood group but whether they have a variant Rh type,” said Sara Trompeter, MB ChB, a consultant hematologist for NHSBT.

“And there will also be greater safety and likelihood of getting matched blood in an emergency, as their records will be held centrally and can be accessed by blood banks in local hospitals. We would urge all patients with hemoglobin disorders such as sickle cell disease or thalassemia to speak to their medical or nursing team about providing a blood sample to NHS Blood and Transplant via their local transfusion laboratories to be genotyped.”

Additional information on this initiative can be found at www.nhsbt.nhs.uk/extendedbloodgrouptesting.

Joseph Panoff, MD

Photo courtesy of Sylvester

Comprehensive Cancer Center

In a retrospective study, young African American patients with Hodgkin lymphoma (HL) had inferior long-term overall survival when compared to their Hispanic and white peers.

Hispanic and white patients had similar rates of overall survival, but Hispanic males had inferior disease-specific survival compared to white males.

The study, published in Pediatric Blood & Cancer, is the largest yet on racial and ethnic disparity in the pediatric HL population in the US.

“Little was known about the association between race, ethnicity, and survival in the pediatric Hodgkin lymphoma population,” said Joseph Panoff, MD, of Sylvester Comprehensive Cancer Center at the University of Miami in Florida.

“Our study showed that African American children and teenagers had worse overall survival than whites and Hispanics at 25 years after diagnosis. We also found that Hispanic males had inferior disease-specific survival compared to white males.”

Dr Panoff and his colleagues analyzed data from more than 7800 patients listed in the Florida Cancer Data System (FCDS) and the National Institutes of Health’s Surveillance, Epidemiology, and End Results Program (SEER).

The patients were 0.1 to 21 years of age (average, 17 years) and were diagnosed with HL from 1981 to 2010.

In the FCDS cohort, which was significantly smaller than the SEER cohort (1778 vs 6027), African Americans had a 33% overall survival rate at 25 years, compared to 44.7% for Hispanics and 49.2% for whites (P=0.0005).

In a multivariate analysis, African American race was associated with inferior overall survival. The hazard ratio was 1.81 (P=0.0003).

Patients in the FCDS cohort had worse overall survival than patients in the SEER cohort, indicating that patients treated in Florida have worse outcomes when compared to the rest of the nation.

In the SEER cohort, the overall survival rate at 25 years was 74.2% for African Americans and 82% for both Hispanic and white patients (P=0.0005). Disease-specific survival rates at 25 years were 85.7% for African Americans, 88.1% for Hispanics, and 90.8% for whites (P=0.0002).

The researchers noted that Hispanic males had inferior disease-specific survival when compared to white males—84.8% and 90.6%, respectively (P=0.0478).

And Hispanic race was a predictor of inferior disease-specific survival in multivariate analysis. The hazard ratio was 1.238 (P<0.0001).

“Clearly, racial and ethnic disparities persist in the pediatric Hodgkin lymphoma population, despite modern treatment, particularly in Florida,” Dr Panoff noted. “The underlying causes of these disparities are complex and need further explanation.”

As a next step, Dr Panoff suggests identifying flaws in the diagnostic and treatment process with regard to African American and Hispanic patients.

“It is important to identify sociocultural factors and health behaviors that negatively affect overall survival in African American patients and disease-free survival in Hispanic males,” he said. “The fact that the entire Florida cohort seems to have worse overall survival than patients in the rest of the country is a new finding that requires further research.”

Joseph Panoff, MD

Photo courtesy of Sylvester

Comprehensive Cancer Center

In a retrospective study, young African American patients with Hodgkin lymphoma (HL) had inferior long-term overall survival when compared to their Hispanic and white peers.

Hispanic and white patients had similar rates of overall survival, but Hispanic males had inferior disease-specific survival compared to white males.

The study, published in Pediatric Blood & Cancer, is the largest yet on racial and ethnic disparity in the pediatric HL population in the US.

“Little was known about the association between race, ethnicity, and survival in the pediatric Hodgkin lymphoma population,” said Joseph Panoff, MD, of Sylvester Comprehensive Cancer Center at the University of Miami in Florida.

“Our study showed that African American children and teenagers had worse overall survival than whites and Hispanics at 25 years after diagnosis. We also found that Hispanic males had inferior disease-specific survival compared to white males.”

Dr Panoff and his colleagues analyzed data from more than 7800 patients listed in the Florida Cancer Data System (FCDS) and the National Institutes of Health’s Surveillance, Epidemiology, and End Results Program (SEER).

The patients were 0.1 to 21 years of age (average, 17 years) and were diagnosed with HL from 1981 to 2010.

In the FCDS cohort, which was significantly smaller than the SEER cohort (1778 vs 6027), African Americans had a 33% overall survival rate at 25 years, compared to 44.7% for Hispanics and 49.2% for whites (P=0.0005).

In a multivariate analysis, African American race was associated with inferior overall survival. The hazard ratio was 1.81 (P=0.0003).

Patients in the FCDS cohort had worse overall survival than patients in the SEER cohort, indicating that patients treated in Florida have worse outcomes when compared to the rest of the nation.

In the SEER cohort, the overall survival rate at 25 years was 74.2% for African Americans and 82% for both Hispanic and white patients (P=0.0005). Disease-specific survival rates at 25 years were 85.7% for African Americans, 88.1% for Hispanics, and 90.8% for whites (P=0.0002).

The researchers noted that Hispanic males had inferior disease-specific survival when compared to white males—84.8% and 90.6%, respectively (P=0.0478).

And Hispanic race was a predictor of inferior disease-specific survival in multivariate analysis. The hazard ratio was 1.238 (P<0.0001).

“Clearly, racial and ethnic disparities persist in the pediatric Hodgkin lymphoma population, despite modern treatment, particularly in Florida,” Dr Panoff noted. “The underlying causes of these disparities are complex and need further explanation.”

As a next step, Dr Panoff suggests identifying flaws in the diagnostic and treatment process with regard to African American and Hispanic patients.

“It is important to identify sociocultural factors and health behaviors that negatively affect overall survival in African American patients and disease-free survival in Hispanic males,” he said. “The fact that the entire Florida cohort seems to have worse overall survival than patients in the rest of the country is a new finding that requires further research.”

Joseph Panoff, MD

Photo courtesy of Sylvester

Comprehensive Cancer Center

In a retrospective study, young African American patients with Hodgkin lymphoma (HL) had inferior long-term overall survival when compared to their Hispanic and white peers.

Hispanic and white patients had similar rates of overall survival, but Hispanic males had inferior disease-specific survival compared to white males.

The study, published in Pediatric Blood & Cancer, is the largest yet on racial and ethnic disparity in the pediatric HL population in the US.

“Little was known about the association between race, ethnicity, and survival in the pediatric Hodgkin lymphoma population,” said Joseph Panoff, MD, of Sylvester Comprehensive Cancer Center at the University of Miami in Florida.

“Our study showed that African American children and teenagers had worse overall survival than whites and Hispanics at 25 years after diagnosis. We also found that Hispanic males had inferior disease-specific survival compared to white males.”

Dr Panoff and his colleagues analyzed data from more than 7800 patients listed in the Florida Cancer Data System (FCDS) and the National Institutes of Health’s Surveillance, Epidemiology, and End Results Program (SEER).

The patients were 0.1 to 21 years of age (average, 17 years) and were diagnosed with HL from 1981 to 2010.

In the FCDS cohort, which was significantly smaller than the SEER cohort (1778 vs 6027), African Americans had a 33% overall survival rate at 25 years, compared to 44.7% for Hispanics and 49.2% for whites (P=0.0005).

In a multivariate analysis, African American race was associated with inferior overall survival. The hazard ratio was 1.81 (P=0.0003).

Patients in the FCDS cohort had worse overall survival than patients in the SEER cohort, indicating that patients treated in Florida have worse outcomes when compared to the rest of the nation.

In the SEER cohort, the overall survival rate at 25 years was 74.2% for African Americans and 82% for both Hispanic and white patients (P=0.0005). Disease-specific survival rates at 25 years were 85.7% for African Americans, 88.1% for Hispanics, and 90.8% for whites (P=0.0002).

The researchers noted that Hispanic males had inferior disease-specific survival when compared to white males—84.8% and 90.6%, respectively (P=0.0478).

And Hispanic race was a predictor of inferior disease-specific survival in multivariate analysis. The hazard ratio was 1.238 (P<0.0001).

“Clearly, racial and ethnic disparities persist in the pediatric Hodgkin lymphoma population, despite modern treatment, particularly in Florida,” Dr Panoff noted. “The underlying causes of these disparities are complex and need further explanation.”

As a next step, Dr Panoff suggests identifying flaws in the diagnostic and treatment process with regard to African American and Hispanic patients.

“It is important to identify sociocultural factors and health behaviors that negatively affect overall survival in African American patients and disease-free survival in Hispanic males,” he said. “The fact that the entire Florida cohort seems to have worse overall survival than patients in the rest of the country is a new finding that requires further research.”

Genetically modified zebrafish

Research published in PNAS has shed new light on the mechanism by which hemangioblasts become blood cells.

Hemangioblasts, which give rise to both hematopoietic and endothelial progenitors, have been identified in the embryos of chickens, mice, fish, and humans. It has also become clear that the cells are present in adult organisms.

However, the mechanism by which hemangioblasts differentiate into blood cells and vascular endothelia has remained a mystery in many aspects.

With that in mind, Makoto Kobayashi, PhD, of the University of Tsukuba in Japan, and his colleagues studied hemangioblasts in zebrafish.

The investigators looked for zebrafish mutants with defects in the hemangioblast expression of Gata1, which is not expressed in endothelial progenitors.

This revealed a mutant with downregulation of hematopoietic genes and upregulation of endothelial genes.

The team then identified the gene responsible for this mutant—LSD1. Additional experiments showed that LSD1 silences Etv2, a critical regulator of hemangioblast development.

The investigators said these results indicate that epigenetic silencing of Etv2 by LSD1 may be a significant event required for hemangioblasts to initiate hematopoietic differentiation.

Genetically modified zebrafish

Research published in PNAS has shed new light on the mechanism by which hemangioblasts become blood cells.

Hemangioblasts, which give rise to both hematopoietic and endothelial progenitors, have been identified in the embryos of chickens, mice, fish, and humans. It has also become clear that the cells are present in adult organisms.

However, the mechanism by which hemangioblasts differentiate into blood cells and vascular endothelia has remained a mystery in many aspects.

With that in mind, Makoto Kobayashi, PhD, of the University of Tsukuba in Japan, and his colleagues studied hemangioblasts in zebrafish.

The investigators looked for zebrafish mutants with defects in the hemangioblast expression of Gata1, which is not expressed in endothelial progenitors.

This revealed a mutant with downregulation of hematopoietic genes and upregulation of endothelial genes.

The team then identified the gene responsible for this mutant—LSD1. Additional experiments showed that LSD1 silences Etv2, a critical regulator of hemangioblast development.

The investigators said these results indicate that epigenetic silencing of Etv2 by LSD1 may be a significant event required for hemangioblasts to initiate hematopoietic differentiation.

Genetically modified zebrafish

Research published in PNAS has shed new light on the mechanism by which hemangioblasts become blood cells.

Hemangioblasts, which give rise to both hematopoietic and endothelial progenitors, have been identified in the embryos of chickens, mice, fish, and humans. It has also become clear that the cells are present in adult organisms.

However, the mechanism by which hemangioblasts differentiate into blood cells and vascular endothelia has remained a mystery in many aspects.

With that in mind, Makoto Kobayashi, PhD, of the University of Tsukuba in Japan, and his colleagues studied hemangioblasts in zebrafish.

The investigators looked for zebrafish mutants with defects in the hemangioblast expression of Gata1, which is not expressed in endothelial progenitors.

This revealed a mutant with downregulation of hematopoietic genes and upregulation of endothelial genes.

The team then identified the gene responsible for this mutant—LSD1. Additional experiments showed that LSD1 silences Etv2, a critical regulator of hemangioblast development.

The investigators said these results indicate that epigenetic silencing of Etv2 by LSD1 may be a significant event required for hemangioblasts to initiate hematopoietic differentiation.