The Pitt Hopkins Research Foundation Scientific Symposium and Family Conference will take place November 3-5 in Dallas, Texas.

The Pitt Hopkins Research Foundation Scientific Symposium and Family Conference will take place November 3-5 in Dallas, Texas.

The Pitt Hopkins Research Foundation Scientific Symposium and Family Conference will take place November 3-5 in Dallas, Texas.

Clinician Andrew Morris of the UK is interviewed about the importance of timely diagnosis of homocystinuria in a brief video published recently by the HCU Network Australia.

Clinician Andrew Morris of the UK is interviewed about the importance of timely diagnosis of homocystinuria in a brief video published recently by the HCU Network Australia.

Clinician Andrew Morris of the UK is interviewed about the importance of timely diagnosis of homocystinuria in a brief video published recently by the HCU Network Australia.

The Lucile Packard Foundation for Children’s Health seeks applications for grants to develop single-topic issue briefs that describe goals and processes to improve aspects of the systems of care for children with chronic and complex health conditions in the US. Proposals are due September 15.

The Lucile Packard Foundation for Children’s Health seeks applications for grants to develop single-topic issue briefs that describe goals and processes to improve aspects of the systems of care for children with chronic and complex health conditions in the US. Proposals are due September 15.

The Lucile Packard Foundation for Children’s Health seeks applications for grants to develop single-topic issue briefs that describe goals and processes to improve aspects of the systems of care for children with chronic and complex health conditions in the US. Proposals are due September 15.

The American College of Physicians Initiative has developed a toolkit to facilitate more effective transition of young adults from pediatric to adult care. The kit includes a major focus on providing a framework for the adult care provider.

The American College of Physicians Initiative has developed a toolkit to facilitate more effective transition of young adults from pediatric to adult care. The kit includes a major focus on providing a framework for the adult care provider.

The American College of Physicians Initiative has developed a toolkit to facilitate more effective transition of young adults from pediatric to adult care. The kit includes a major focus on providing a framework for the adult care provider.

The July issue of ACS Surgery News in digital format is available online. Use the mobile app to download or view as a pdf.

This month’s issue features coverage of the report, “A National Trauma Care System: Integrating Civilian and Military Trauma Systems to Achieve Zero Preventable Deaths After Injury,” released by the National Academies of Sciences, Engineering, and Medicine. The report, supported in part by the American College of Surgeons, gives a detailed list of policy recommendations that would create a unified trauma response system incorporating lessons learned from combat mission with the aim of eliminating unnecessary deaths in civilian trauma situations (p. 1).

Looking for some summer reading? Dr. Carol Scott-Conner, moderator of the ACS Communities Surgeon Writers discussion group, reviews three books by surgeons that should be of special interest to the readers of ACS Surgery News. All three works concern personal experience and reflections on the profession (p. 4).

Don’t miss the story (p. 7) on peer review hearings and how best to approach this situation. These hearings should be informative and educational, but can also play out in unexpected ways. Be prepared!

The July issue of ACS Surgery News in digital format is available online. Use the mobile app to download or view as a pdf.

This month’s issue features coverage of the report, “A National Trauma Care System: Integrating Civilian and Military Trauma Systems to Achieve Zero Preventable Deaths After Injury,” released by the National Academies of Sciences, Engineering, and Medicine. The report, supported in part by the American College of Surgeons, gives a detailed list of policy recommendations that would create a unified trauma response system incorporating lessons learned from combat mission with the aim of eliminating unnecessary deaths in civilian trauma situations (p. 1).

Looking for some summer reading? Dr. Carol Scott-Conner, moderator of the ACS Communities Surgeon Writers discussion group, reviews three books by surgeons that should be of special interest to the readers of ACS Surgery News. All three works concern personal experience and reflections on the profession (p. 4).

Don’t miss the story (p. 7) on peer review hearings and how best to approach this situation. These hearings should be informative and educational, but can also play out in unexpected ways. Be prepared!

The July issue of ACS Surgery News in digital format is available online. Use the mobile app to download or view as a pdf.

This month’s issue features coverage of the report, “A National Trauma Care System: Integrating Civilian and Military Trauma Systems to Achieve Zero Preventable Deaths After Injury,” released by the National Academies of Sciences, Engineering, and Medicine. The report, supported in part by the American College of Surgeons, gives a detailed list of policy recommendations that would create a unified trauma response system incorporating lessons learned from combat mission with the aim of eliminating unnecessary deaths in civilian trauma situations (p. 1).

Looking for some summer reading? Dr. Carol Scott-Conner, moderator of the ACS Communities Surgeon Writers discussion group, reviews three books by surgeons that should be of special interest to the readers of ACS Surgery News. All three works concern personal experience and reflections on the profession (p. 4).

Don’t miss the story (p. 7) on peer review hearings and how best to approach this situation. These hearings should be informative and educational, but can also play out in unexpected ways. Be prepared!

WASHINGTON – As practices merge, how hard is it to merge EHRs?

Even in what might seem to be the best circumstances, it can be a huge challenge, according to Jacqueline Fincher, MD, of McDuffie Medical Associates, Thompson, Ga.

One appealing aspect of the merger of Dr. Fincher’s practice with another was that each practice used an EHR from the same vendor and each was operating with the same updates.

Gregory Twachtman/Frontline Medical News

“This is the perfect setup,” she said at the annual meeting of the American College of Physicians. “We don’t have to go to Epic. We can stay on the same EHR. In fact, this group had gone on the same EHR back in 2006 within a month of the time that we went on; we were on the exact same version and the same everything. We were totally even. The thought among the corporate and IT staff of the new entity was that this is going to be seamless. We’re just going to renumber the accounts and everything will be just fine.”

A call to the EHR vendor, whom she did not name, revealed that the process would be anything but seamless.

“Our IT staff contacted our common EHR vendor and said we want to merge this practice with our bigger practice and the EHR company said, ‘Wow, we’ve never done that before.’ What? In this day of consolidation and integration, they had never done it before? Nor did they have a business model to do so, much less a digital plan to do so. That was pretty shocking,” she said.

Dr. Fincher noted that the EHR vendor recommended a third party vendor to handle creating an interface between the two EHRs. “Most EHR companies do not, I say, do not have a dedicated service to migrate data. It’s almost always going out to a third-party conversion service that doesn’t know you, doesn’t know your work flow, and makes everything even more difficult.”

Two and a half months – and 10 interfaces – later, the launch of the combined EHR was a disaster, Dr. Fincher said.

Even though both practices were using the exact same version of the EHR, each had very different work flows, defaults, and other nuances that meant data didn’t transfer smoothly – cheaply.

Among the surprise expenses: about $55,000 for additional hardware, network cabling and interfaces; $35,000 for additional servers; and at least $100,000 for personnel expenses related to the data migration.

Given her experience, Dr. Fincher advised her peers “to start at least 6 months in advance to map and convert the data.”

And it is vital to get input and participation from all office stakeholders – both clinical and administrative staff – regarding how the data is migrated, she said. Be sure to completely understand all work flows from both practices so that you know how the data is going to migrate.

“Understanding work flow, that is absolutely critical. Every single office has a different work flow for every type of encounter by any method. How these work flows are the same or different between your office and the new practice or your EHR and the new EHR that you’re going to, they are different. You have to understand the differences,” she added.

“We didn’t perceive that there was that much difference but when everything crashed, we discovered there were because they had different work flows, they had different defaults in place, those types of things.”

Other key questions: Which data needs to be migrated? How long should the old system remain in place? Should the data be migrated manually or digitally? How much time will the EHR merger take?

“You want to establish that structured planning time,” Dr. Fincher said. “You’ve got to carve out scheduled time with the group in order to do this. Establish the tasks that need to be accomplished, so just making a to-do list every week and who’s going to be accountable to accomplish those parts of the list” is important.

[email protected]

WASHINGTON – As practices merge, how hard is it to merge EHRs?

Even in what might seem to be the best circumstances, it can be a huge challenge, according to Jacqueline Fincher, MD, of McDuffie Medical Associates, Thompson, Ga.

One appealing aspect of the merger of Dr. Fincher’s practice with another was that each practice used an EHR from the same vendor and each was operating with the same updates.

Gregory Twachtman/Frontline Medical News

“This is the perfect setup,” she said at the annual meeting of the American College of Physicians. “We don’t have to go to Epic. We can stay on the same EHR. In fact, this group had gone on the same EHR back in 2006 within a month of the time that we went on; we were on the exact same version and the same everything. We were totally even. The thought among the corporate and IT staff of the new entity was that this is going to be seamless. We’re just going to renumber the accounts and everything will be just fine.”

A call to the EHR vendor, whom she did not name, revealed that the process would be anything but seamless.

“Our IT staff contacted our common EHR vendor and said we want to merge this practice with our bigger practice and the EHR company said, ‘Wow, we’ve never done that before.’ What? In this day of consolidation and integration, they had never done it before? Nor did they have a business model to do so, much less a digital plan to do so. That was pretty shocking,” she said.

Dr. Fincher noted that the EHR vendor recommended a third party vendor to handle creating an interface between the two EHRs. “Most EHR companies do not, I say, do not have a dedicated service to migrate data. It’s almost always going out to a third-party conversion service that doesn’t know you, doesn’t know your work flow, and makes everything even more difficult.”

Two and a half months – and 10 interfaces – later, the launch of the combined EHR was a disaster, Dr. Fincher said.

Even though both practices were using the exact same version of the EHR, each had very different work flows, defaults, and other nuances that meant data didn’t transfer smoothly – cheaply.

Among the surprise expenses: about $55,000 for additional hardware, network cabling and interfaces; $35,000 for additional servers; and at least $100,000 for personnel expenses related to the data migration.

Given her experience, Dr. Fincher advised her peers “to start at least 6 months in advance to map and convert the data.”

And it is vital to get input and participation from all office stakeholders – both clinical and administrative staff – regarding how the data is migrated, she said. Be sure to completely understand all work flows from both practices so that you know how the data is going to migrate.

“Understanding work flow, that is absolutely critical. Every single office has a different work flow for every type of encounter by any method. How these work flows are the same or different between your office and the new practice or your EHR and the new EHR that you’re going to, they are different. You have to understand the differences,” she added.

“We didn’t perceive that there was that much difference but when everything crashed, we discovered there were because they had different work flows, they had different defaults in place, those types of things.”

Other key questions: Which data needs to be migrated? How long should the old system remain in place? Should the data be migrated manually or digitally? How much time will the EHR merger take?

“You want to establish that structured planning time,” Dr. Fincher said. “You’ve got to carve out scheduled time with the group in order to do this. Establish the tasks that need to be accomplished, so just making a to-do list every week and who’s going to be accountable to accomplish those parts of the list” is important.

[email protected]

WASHINGTON – As practices merge, how hard is it to merge EHRs?

Even in what might seem to be the best circumstances, it can be a huge challenge, according to Jacqueline Fincher, MD, of McDuffie Medical Associates, Thompson, Ga.

One appealing aspect of the merger of Dr. Fincher’s practice with another was that each practice used an EHR from the same vendor and each was operating with the same updates.

Gregory Twachtman/Frontline Medical News

“This is the perfect setup,” she said at the annual meeting of the American College of Physicians. “We don’t have to go to Epic. We can stay on the same EHR. In fact, this group had gone on the same EHR back in 2006 within a month of the time that we went on; we were on the exact same version and the same everything. We were totally even. The thought among the corporate and IT staff of the new entity was that this is going to be seamless. We’re just going to renumber the accounts and everything will be just fine.”

A call to the EHR vendor, whom she did not name, revealed that the process would be anything but seamless.

“Our IT staff contacted our common EHR vendor and said we want to merge this practice with our bigger practice and the EHR company said, ‘Wow, we’ve never done that before.’ What? In this day of consolidation and integration, they had never done it before? Nor did they have a business model to do so, much less a digital plan to do so. That was pretty shocking,” she said.

Dr. Fincher noted that the EHR vendor recommended a third party vendor to handle creating an interface between the two EHRs. “Most EHR companies do not, I say, do not have a dedicated service to migrate data. It’s almost always going out to a third-party conversion service that doesn’t know you, doesn’t know your work flow, and makes everything even more difficult.”

Two and a half months – and 10 interfaces – later, the launch of the combined EHR was a disaster, Dr. Fincher said.

Even though both practices were using the exact same version of the EHR, each had very different work flows, defaults, and other nuances that meant data didn’t transfer smoothly – cheaply.

Among the surprise expenses: about $55,000 for additional hardware, network cabling and interfaces; $35,000 for additional servers; and at least $100,000 for personnel expenses related to the data migration.

Given her experience, Dr. Fincher advised her peers “to start at least 6 months in advance to map and convert the data.”

And it is vital to get input and participation from all office stakeholders – both clinical and administrative staff – regarding how the data is migrated, she said. Be sure to completely understand all work flows from both practices so that you know how the data is going to migrate.

“Understanding work flow, that is absolutely critical. Every single office has a different work flow for every type of encounter by any method. How these work flows are the same or different between your office and the new practice or your EHR and the new EHR that you’re going to, they are different. You have to understand the differences,” she added.

“We didn’t perceive that there was that much difference but when everything crashed, we discovered there were because they had different work flows, they had different defaults in place, those types of things.”

Other key questions: Which data needs to be migrated? How long should the old system remain in place? Should the data be migrated manually or digitally? How much time will the EHR merger take?

“You want to establish that structured planning time,” Dr. Fincher said. “You’ve got to carve out scheduled time with the group in order to do this. Establish the tasks that need to be accomplished, so just making a to-do list every week and who’s going to be accountable to accomplish those parts of the list” is important.

[email protected]

The preliminary scientific program, along with registration and housing information, is now online for AATS Focus on Thoracic Surgery: Novel Techniques in Lung Cancer.

November 21 – 22, 2014

Renaissance Boston Waterfront Hotel

Boston, MA, USA

Take advantage of early registration rates and register before October 23rd!

http://aats.org/lungcancer

Program Directors

G. Alec Patterson, Washington University

David J. Sugarbaker, Baylor College of Medicine

Program Committee Members:

Thomas A. D’Amico, Duke University

Shaf Keshavjee, University of Toronto

James D. Luketich, University of Pittsburgh

Bryan F. Meyers, Washington University

Scott J. Swanson, Brigham and Women’s Hospital

Overview

Lung cancer is the most common cause of cancer-related deaths and second most common malignancy in the Western world. Recent innovations in diagnosis, staging and management of early stage and locally advanced non-small cell lung cancer have changed the paradigm for patient surgical management. There has also been a virtual explosion of technological developments enabling widespread use of minimally invasive techniques, which current and future thoracic surgeons will need to embrace in order to improve patient care.

Join AATS in Boston for the 2014 Focus On Thoracic Surgery whose program will focus on recent developments in Novel Technologies in Lung Cancer. The faculty includes internationally recognized experts in the field, including those knowledgeable about the use of new technology in lung cancer surgical management.

Program Highlights

Imaging and Staging

Surgical Alternatives

Simulation, Education, and Training

Optimal Management of Lung Metastases

Credentialing/ Efficiencies

Intraoperative Management

Video Sessions - Advanced Minimally Invasive Techniques

Honored Guest Speaker

Larry R. KaiserDean, Temple University

The preliminary scientific program, along with registration and housing information, is now online for AATS Focus on Thoracic Surgery: Novel Techniques in Lung Cancer.

November 21 – 22, 2014

Renaissance Boston Waterfront Hotel

Boston, MA, USA

Take advantage of early registration rates and register before October 23rd!

http://aats.org/lungcancer

Program Directors

G. Alec Patterson, Washington University

David J. Sugarbaker, Baylor College of Medicine

Program Committee Members:

Thomas A. D’Amico, Duke University

Shaf Keshavjee, University of Toronto

James D. Luketich, University of Pittsburgh

Bryan F. Meyers, Washington University

Scott J. Swanson, Brigham and Women’s Hospital

Overview

Lung cancer is the most common cause of cancer-related deaths and second most common malignancy in the Western world. Recent innovations in diagnosis, staging and management of early stage and locally advanced non-small cell lung cancer have changed the paradigm for patient surgical management. There has also been a virtual explosion of technological developments enabling widespread use of minimally invasive techniques, which current and future thoracic surgeons will need to embrace in order to improve patient care.

Join AATS in Boston for the 2014 Focus On Thoracic Surgery whose program will focus on recent developments in Novel Technologies in Lung Cancer. The faculty includes internationally recognized experts in the field, including those knowledgeable about the use of new technology in lung cancer surgical management.

Program Highlights

Imaging and Staging

Surgical Alternatives

Simulation, Education, and Training

Optimal Management of Lung Metastases

Credentialing/ Efficiencies

Intraoperative Management

Video Sessions - Advanced Minimally Invasive Techniques

Honored Guest Speaker

Larry R. KaiserDean, Temple University

The preliminary scientific program, along with registration and housing information, is now online for AATS Focus on Thoracic Surgery: Novel Techniques in Lung Cancer.

November 21 – 22, 2014

Renaissance Boston Waterfront Hotel

Boston, MA, USA

Take advantage of early registration rates and register before October 23rd!

http://aats.org/lungcancer

Program Directors

G. Alec Patterson, Washington University

David J. Sugarbaker, Baylor College of Medicine

Program Committee Members:

Thomas A. D’Amico, Duke University

Shaf Keshavjee, University of Toronto

James D. Luketich, University of Pittsburgh

Bryan F. Meyers, Washington University

Scott J. Swanson, Brigham and Women’s Hospital

Overview

Lung cancer is the most common cause of cancer-related deaths and second most common malignancy in the Western world. Recent innovations in diagnosis, staging and management of early stage and locally advanced non-small cell lung cancer have changed the paradigm for patient surgical management. There has also been a virtual explosion of technological developments enabling widespread use of minimally invasive techniques, which current and future thoracic surgeons will need to embrace in order to improve patient care.

Join AATS in Boston for the 2014 Focus On Thoracic Surgery whose program will focus on recent developments in Novel Technologies in Lung Cancer. The faculty includes internationally recognized experts in the field, including those knowledgeable about the use of new technology in lung cancer surgical management.

Program Highlights

Imaging and Staging

Surgical Alternatives

Simulation, Education, and Training

Optimal Management of Lung Metastases

Credentialing/ Efficiencies

Intraoperative Management

Video Sessions - Advanced Minimally Invasive Techniques

Honored Guest Speaker

Larry R. KaiserDean, Temple University

Rates of hepatitis C virus detection increased in U.S. women aged 15-44 years and in children less than 2 years old from 2011 to 2014, according to investigators from the Centers for Disease Control and Prevention.

A report published July 21 in Morbidity and Mortality Weekly Report revealed hepatitis C virus (HCV) detection rates (detection via antibody or RNA positivity) that were determined using data collected from Quest Diagnostics for Kentucky and for the United States. In Kentucky, the rate of HCV detection in women aged 15-44 increased 213% over the study period, from 275 to 862 cases per 100,000 people, and for the entire U.S., the rate of detection increased by 22% from 139 to 169 cases per 100,000 people (65[28]:705-10).

The rate of HCV testing for children under 2 years old in Kentucky increased 151% over the study period, rising from 403 to 1,011 per 100,000 people, and the rate of children born to HCV-positive mothers increased from 0.71% to 1.59%. Nationwide, the HCV testing rate for children under 2 years old increased 14% from 310 to 353 per 100,000, and the rate of children born to HCV-positive mothers increased from 0.19% to 0.32%.

“These findings underscore the importance of providing primary prevention services and following current recommendations to identify persons at risk for HCV infection and test accordingly; doing so among pregnant women would improve early identification of HCV-infected infants and linkage of the mother and infant to care and treatment,” the CDC investigators said.

Rates of hepatitis C virus detection increased in U.S. women aged 15-44 years and in children less than 2 years old from 2011 to 2014, according to investigators from the Centers for Disease Control and Prevention.

A report published July 21 in Morbidity and Mortality Weekly Report revealed hepatitis C virus (HCV) detection rates (detection via antibody or RNA positivity) that were determined using data collected from Quest Diagnostics for Kentucky and for the United States. In Kentucky, the rate of HCV detection in women aged 15-44 increased 213% over the study period, from 275 to 862 cases per 100,000 people, and for the entire U.S., the rate of detection increased by 22% from 139 to 169 cases per 100,000 people (65[28]:705-10).

The rate of HCV testing for children under 2 years old in Kentucky increased 151% over the study period, rising from 403 to 1,011 per 100,000 people, and the rate of children born to HCV-positive mothers increased from 0.71% to 1.59%. Nationwide, the HCV testing rate for children under 2 years old increased 14% from 310 to 353 per 100,000, and the rate of children born to HCV-positive mothers increased from 0.19% to 0.32%.

“These findings underscore the importance of providing primary prevention services and following current recommendations to identify persons at risk for HCV infection and test accordingly; doing so among pregnant women would improve early identification of HCV-infected infants and linkage of the mother and infant to care and treatment,” the CDC investigators said.

Rates of hepatitis C virus detection increased in U.S. women aged 15-44 years and in children less than 2 years old from 2011 to 2014, according to investigators from the Centers for Disease Control and Prevention.

A report published July 21 in Morbidity and Mortality Weekly Report revealed hepatitis C virus (HCV) detection rates (detection via antibody or RNA positivity) that were determined using data collected from Quest Diagnostics for Kentucky and for the United States. In Kentucky, the rate of HCV detection in women aged 15-44 increased 213% over the study period, from 275 to 862 cases per 100,000 people, and for the entire U.S., the rate of detection increased by 22% from 139 to 169 cases per 100,000 people (65[28]:705-10).

The rate of HCV testing for children under 2 years old in Kentucky increased 151% over the study period, rising from 403 to 1,011 per 100,000 people, and the rate of children born to HCV-positive mothers increased from 0.71% to 1.59%. Nationwide, the HCV testing rate for children under 2 years old increased 14% from 310 to 353 per 100,000, and the rate of children born to HCV-positive mothers increased from 0.19% to 0.32%.

“These findings underscore the importance of providing primary prevention services and following current recommendations to identify persons at risk for HCV infection and test accordingly; doing so among pregnant women would improve early identification of HCV-infected infants and linkage of the mother and infant to care and treatment,” the CDC investigators said.

Rates of hepatitis C virus detection increased in U.S. women aged 15-44 years and in children less than 2 years old from 2011 to 2014, according to investigators from the Centers for Disease Control and Prevention.

A report published July 21 in Morbidity and Mortality Weekly Report revealed hepatitis C virus (HCV) detection rates (detection via antibody or RNA positivity) that were determined using data collected from Quest Diagnostics for Kentucky and for the United States. In Kentucky, the rate of HCV detection in women aged 15-44 increased 213% over the study period, from 275 to 862 cases per 100,000 people, and for the entire U.S., the rate of detection increased by 22% from 139 to 169 cases per 100,000 people (65[28]:705-10).

The rate of HCV testing for children under 2 years old in Kentucky increased 151% over the study period, rising from 403 to 1,011 per 100,000 people, and the rate of children born to HCV-positive mothers increased from 0.71% to 1.59%. Nationwide, the HCV testing rate for children under 2 years old increased 14% from 310 to 353 per 100,000, and the rate of children born to HCV-positive mothers increased from 0.19% to 0.32%.

“These findings underscore the importance of providing primary prevention services and following current recommendations to identify persons at risk for HCV infection and test accordingly; doing so among pregnant women would improve early identification of HCV-infected infants and linkage of the mother and infant to care and treatment,” the CDC investigators said.

[email protected]

Rates of hepatitis C virus detection increased in U.S. women aged 15-44 years and in children less than 2 years old from 2011 to 2014, according to investigators from the Centers for Disease Control and Prevention.

A report published July 21 in Morbidity and Mortality Weekly Report revealed hepatitis C virus (HCV) detection rates (detection via antibody or RNA positivity) that were determined using data collected from Quest Diagnostics for Kentucky and for the United States. In Kentucky, the rate of HCV detection in women aged 15-44 increased 213% over the study period, from 275 to 862 cases per 100,000 people, and for the entire U.S., the rate of detection increased by 22% from 139 to 169 cases per 100,000 people (65[28]:705-10).

The rate of HCV testing for children under 2 years old in Kentucky increased 151% over the study period, rising from 403 to 1,011 per 100,000 people, and the rate of children born to HCV-positive mothers increased from 0.71% to 1.59%. Nationwide, the HCV testing rate for children under 2 years old increased 14% from 310 to 353 per 100,000, and the rate of children born to HCV-positive mothers increased from 0.19% to 0.32%.

“These findings underscore the importance of providing primary prevention services and following current recommendations to identify persons at risk for HCV infection and test accordingly; doing so among pregnant women would improve early identification of HCV-infected infants and linkage of the mother and infant to care and treatment,” the CDC investigators said.

[email protected]

Rates of hepatitis C virus detection increased in U.S. women aged 15-44 years and in children less than 2 years old from 2011 to 2014, according to investigators from the Centers for Disease Control and Prevention.

A report published July 21 in Morbidity and Mortality Weekly Report revealed hepatitis C virus (HCV) detection rates (detection via antibody or RNA positivity) that were determined using data collected from Quest Diagnostics for Kentucky and for the United States. In Kentucky, the rate of HCV detection in women aged 15-44 increased 213% over the study period, from 275 to 862 cases per 100,000 people, and for the entire U.S., the rate of detection increased by 22% from 139 to 169 cases per 100,000 people (65[28]:705-10).

The rate of HCV testing for children under 2 years old in Kentucky increased 151% over the study period, rising from 403 to 1,011 per 100,000 people, and the rate of children born to HCV-positive mothers increased from 0.71% to 1.59%. Nationwide, the HCV testing rate for children under 2 years old increased 14% from 310 to 353 per 100,000, and the rate of children born to HCV-positive mothers increased from 0.19% to 0.32%.

“These findings underscore the importance of providing primary prevention services and following current recommendations to identify persons at risk for HCV infection and test accordingly; doing so among pregnant women would improve early identification of HCV-infected infants and linkage of the mother and infant to care and treatment,” the CDC investigators said.

[email protected]

HELSINKI, FINLAND – Recombinant human growth hormone, or r-HGH, offered no advantage over placebo with respect to improving the live birth rate among poor-responding women undergoing in vitro fertilization in a randomized controlled study.

The current findings and those from previous studies leave questions about the value of r-HGH supplementation unanswered, Robert Norman, MD, said at the annual meeting of the European Society of Human Reproduction and Embryology.

©ktsimage/iStockphoto.com

An “extremely large” randomized trial would be needed to definitively show whether poor IVF responders benefit from r-HGH supplementation, he said.

The clinical pregnancy rate in 66 women randomized to receive r-HGH in the current study was 9.1%, compared with 9.2% in 65 patients in the placebo group. In the groups, respectively, the mean number of oocytes collected was 5.38 and 4.96, median embryo quality was 2.00 and 2.14, median days of a study drug were 8 and 9, and in both groups the median number of days of follicle stimulating hormone was 8, and the mean number of embryos transferred was 1.

The overall live birth rate per patient randomized was 12.3%; the groups did not differ significantly on any of these measures, said Dr. Norman of the University of Adelaide, and Fertility SA, Australia.

Human growth hormone is known to be important for ovarian steroidogenesis and follicular development, and prior research, including a recent Cochrane Review, has suggested it is associated with a trend toward improved live birth rates when used as an adjunct to IVF in poor responders (though not in routine IVF). The prior studies, however, have been underpowered, involved significant clinical heterogeneity between study groups, were not placebo controlled, and used pregnancy rather than live birth as the endpoint. Further, safety outcomes among patients treated with r-HGH were uncertain, Dr. Norman said.

For the current study, women were recruited from nine fertility centers in Australia and from one center in New Zealand. All met the criteria for poor response, having had a previous IVF cycle with no more than five eggs collected following maximum stimulation. Of the 131 women randomized, all underwent ovarian stimulation with the same previous drug dose, and 116 had oocyte retrieval, 97 had embryo transfer, 25 reported a positive pregnancy test, and 16 had a live birth, which was the primary endpoint of the study. Three sets of twins were born – all to women in the r-HGH group. Four serious adverse events – all congenital abnormalities – were noted, including three in the r-HGH group and one in the placebo group. No serious adverse events occurred.

Of note, the study, which was expected to be completed in 2 years, was terminated after 4 years because of slow recruitment. Since the 390 patients required to demonstrate a difference between the groups were not enrolled, the study remained underpowered, Dr. Norman said.

Nonetheless, the findings, which highlight the challenges in answering the questions that could shed light on the best clinical treatment for a poor IVF responder, fail to provide any evidence either for benefit or for lack of benefit with the use of r-HGH in this group.

“If it were cheap, it might find a place in poor responders, but normal doses cost more than $1,000,” he said in a press statement regarding the findings.

Poor responders are a notoriously difficult group to treat, and although many strategies have been tried, there is no solid evidence that any of them improve the outcome of most concern to women undergoing IVF: the live birth rate, he added, noting that 30% of patients who are poor IVF responders and who have low pregnancy rates are over 40 years old.

Dr. Norman reported having no financial disclosures.

[email protected]

HELSINKI, FINLAND – Recombinant human growth hormone, or r-HGH, offered no advantage over placebo with respect to improving the live birth rate among poor-responding women undergoing in vitro fertilization in a randomized controlled study.

The current findings and those from previous studies leave questions about the value of r-HGH supplementation unanswered, Robert Norman, MD, said at the annual meeting of the European Society of Human Reproduction and Embryology.

©ktsimage/iStockphoto.com

An “extremely large” randomized trial would be needed to definitively show whether poor IVF responders benefit from r-HGH supplementation, he said.

The clinical pregnancy rate in 66 women randomized to receive r-HGH in the current study was 9.1%, compared with 9.2% in 65 patients in the placebo group. In the groups, respectively, the mean number of oocytes collected was 5.38 and 4.96, median embryo quality was 2.00 and 2.14, median days of a study drug were 8 and 9, and in both groups the median number of days of follicle stimulating hormone was 8, and the mean number of embryos transferred was 1.

The overall live birth rate per patient randomized was 12.3%; the groups did not differ significantly on any of these measures, said Dr. Norman of the University of Adelaide, and Fertility SA, Australia.

Human growth hormone is known to be important for ovarian steroidogenesis and follicular development, and prior research, including a recent Cochrane Review, has suggested it is associated with a trend toward improved live birth rates when used as an adjunct to IVF in poor responders (though not in routine IVF). The prior studies, however, have been underpowered, involved significant clinical heterogeneity between study groups, were not placebo controlled, and used pregnancy rather than live birth as the endpoint. Further, safety outcomes among patients treated with r-HGH were uncertain, Dr. Norman said.

For the current study, women were recruited from nine fertility centers in Australia and from one center in New Zealand. All met the criteria for poor response, having had a previous IVF cycle with no more than five eggs collected following maximum stimulation. Of the 131 women randomized, all underwent ovarian stimulation with the same previous drug dose, and 116 had oocyte retrieval, 97 had embryo transfer, 25 reported a positive pregnancy test, and 16 had a live birth, which was the primary endpoint of the study. Three sets of twins were born – all to women in the r-HGH group. Four serious adverse events – all congenital abnormalities – were noted, including three in the r-HGH group and one in the placebo group. No serious adverse events occurred.

Of note, the study, which was expected to be completed in 2 years, was terminated after 4 years because of slow recruitment. Since the 390 patients required to demonstrate a difference between the groups were not enrolled, the study remained underpowered, Dr. Norman said.

Nonetheless, the findings, which highlight the challenges in answering the questions that could shed light on the best clinical treatment for a poor IVF responder, fail to provide any evidence either for benefit or for lack of benefit with the use of r-HGH in this group.

“If it were cheap, it might find a place in poor responders, but normal doses cost more than $1,000,” he said in a press statement regarding the findings.

Poor responders are a notoriously difficult group to treat, and although many strategies have been tried, there is no solid evidence that any of them improve the outcome of most concern to women undergoing IVF: the live birth rate, he added, noting that 30% of patients who are poor IVF responders and who have low pregnancy rates are over 40 years old.

Dr. Norman reported having no financial disclosures.

[email protected]

HELSINKI, FINLAND – Recombinant human growth hormone, or r-HGH, offered no advantage over placebo with respect to improving the live birth rate among poor-responding women undergoing in vitro fertilization in a randomized controlled study.

The current findings and those from previous studies leave questions about the value of r-HGH supplementation unanswered, Robert Norman, MD, said at the annual meeting of the European Society of Human Reproduction and Embryology.

©ktsimage/iStockphoto.com

An “extremely large” randomized trial would be needed to definitively show whether poor IVF responders benefit from r-HGH supplementation, he said.

The clinical pregnancy rate in 66 women randomized to receive r-HGH in the current study was 9.1%, compared with 9.2% in 65 patients in the placebo group. In the groups, respectively, the mean number of oocytes collected was 5.38 and 4.96, median embryo quality was 2.00 and 2.14, median days of a study drug were 8 and 9, and in both groups the median number of days of follicle stimulating hormone was 8, and the mean number of embryos transferred was 1.

The overall live birth rate per patient randomized was 12.3%; the groups did not differ significantly on any of these measures, said Dr. Norman of the University of Adelaide, and Fertility SA, Australia.

Human growth hormone is known to be important for ovarian steroidogenesis and follicular development, and prior research, including a recent Cochrane Review, has suggested it is associated with a trend toward improved live birth rates when used as an adjunct to IVF in poor responders (though not in routine IVF). The prior studies, however, have been underpowered, involved significant clinical heterogeneity between study groups, were not placebo controlled, and used pregnancy rather than live birth as the endpoint. Further, safety outcomes among patients treated with r-HGH were uncertain, Dr. Norman said.

For the current study, women were recruited from nine fertility centers in Australia and from one center in New Zealand. All met the criteria for poor response, having had a previous IVF cycle with no more than five eggs collected following maximum stimulation. Of the 131 women randomized, all underwent ovarian stimulation with the same previous drug dose, and 116 had oocyte retrieval, 97 had embryo transfer, 25 reported a positive pregnancy test, and 16 had a live birth, which was the primary endpoint of the study. Three sets of twins were born – all to women in the r-HGH group. Four serious adverse events – all congenital abnormalities – were noted, including three in the r-HGH group and one in the placebo group. No serious adverse events occurred.

Of note, the study, which was expected to be completed in 2 years, was terminated after 4 years because of slow recruitment. Since the 390 patients required to demonstrate a difference between the groups were not enrolled, the study remained underpowered, Dr. Norman said.

Nonetheless, the findings, which highlight the challenges in answering the questions that could shed light on the best clinical treatment for a poor IVF responder, fail to provide any evidence either for benefit or for lack of benefit with the use of r-HGH in this group.

“If it were cheap, it might find a place in poor responders, but normal doses cost more than $1,000,” he said in a press statement regarding the findings.

Poor responders are a notoriously difficult group to treat, and although many strategies have been tried, there is no solid evidence that any of them improve the outcome of most concern to women undergoing IVF: the live birth rate, he added, noting that 30% of patients who are poor IVF responders and who have low pregnancy rates are over 40 years old.

Dr. Norman reported having no financial disclosures.

[email protected]