Robot-assisted laparoscopic excision of a rectovaginal endometriotic nodule

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Robot-assisted laparoscopic excision of a rectovaginal endometriotic nodule
A review of key anatomy and a stepwise demonstration of technique

A rectovaginal endometriosis (RVE) is the most severe form of endometriosis. The gold standard for diagnosis is laparoscopy with histologic confirmation. A review of the literature suggests that surgery improves up to 70% of symptoms with generally favorable outcomes.

In this video, we provide a general introduction to endometriosis and a discussion of disease treatment options, ranging from hormonal suppression to radical bowel resections. We also illustrate the steps in robot-assisted laparoscopic excision of an RVE nodule:

  1. identify the borders of the rectosigmoid
  2. dissect the pararectal spaces  
  3. release the rectosigmoid from its attachment to the RVE nodule
  4. identify and isolate the ureter(s)
  5. determine the margins of the nodule  
  6. ensure complete resection.

Excision of an RVE nodule is a technically challenging surgical procedure. Use of the robot for resection is safe and feasible when performed by a trained and experienced surgeon.

I am pleased to bring you this video, and I hope that it is helpful to your practice. 

>> Arnold P. Advincula, MD

 

 

Vidyard Video

 

Share your thoughts! Send your Letter to the Editor to [email protected]. Please include your name and the city and state in which you practice.

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Dr. Madueke-Laveaux is Assistant Attending, Department of Obstetrics & Gynecology, Columbia University Medical Center, New York, New York.

Dr. Simpson is Assistant Professor, Minimally Invasive Gynecology, Johns Hopkins Hospital, Baltimore, Maryland.

Dr. Advincula is the Levine Family Professor of Women’s Health and Vice Chair, Department of Obstetrics & Gynecology, Columbia University Medical Center and Chief of Gynecology, Sloane Hospital for Women at New York-Presbyterian Hospital/Columbia University. He serves on the OBG Management Board of Editors.

Dr. Advincula reports being a consultant to Intuitive Surgical and Titan Medical and having additional financial relationships with Applied Medical, ConMed, and CooperSurgical. The other authors report no relevant financial relationships relevant to this video.

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Dr. Madueke-Laveaux is Assistant Attending, Department of Obstetrics & Gynecology, Columbia University Medical Center, New York, New York.

Dr. Simpson is Assistant Professor, Minimally Invasive Gynecology, Johns Hopkins Hospital, Baltimore, Maryland.

Dr. Advincula is the Levine Family Professor of Women’s Health and Vice Chair, Department of Obstetrics & Gynecology, Columbia University Medical Center and Chief of Gynecology, Sloane Hospital for Women at New York-Presbyterian Hospital/Columbia University. He serves on the OBG Management Board of Editors.

Dr. Advincula reports being a consultant to Intuitive Surgical and Titan Medical and having additional financial relationships with Applied Medical, ConMed, and CooperSurgical. The other authors report no relevant financial relationships relevant to this video.

Author and Disclosure Information

Dr. Madueke-Laveaux is Assistant Attending, Department of Obstetrics & Gynecology, Columbia University Medical Center, New York, New York.

Dr. Simpson is Assistant Professor, Minimally Invasive Gynecology, Johns Hopkins Hospital, Baltimore, Maryland.

Dr. Advincula is the Levine Family Professor of Women’s Health and Vice Chair, Department of Obstetrics & Gynecology, Columbia University Medical Center and Chief of Gynecology, Sloane Hospital for Women at New York-Presbyterian Hospital/Columbia University. He serves on the OBG Management Board of Editors.

Dr. Advincula reports being a consultant to Intuitive Surgical and Titan Medical and having additional financial relationships with Applied Medical, ConMed, and CooperSurgical. The other authors report no relevant financial relationships relevant to this video.

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A review of key anatomy and a stepwise demonstration of technique
A review of key anatomy and a stepwise demonstration of technique

A rectovaginal endometriosis (RVE) is the most severe form of endometriosis. The gold standard for diagnosis is laparoscopy with histologic confirmation. A review of the literature suggests that surgery improves up to 70% of symptoms with generally favorable outcomes.

In this video, we provide a general introduction to endometriosis and a discussion of disease treatment options, ranging from hormonal suppression to radical bowel resections. We also illustrate the steps in robot-assisted laparoscopic excision of an RVE nodule:

  1. identify the borders of the rectosigmoid
  2. dissect the pararectal spaces  
  3. release the rectosigmoid from its attachment to the RVE nodule
  4. identify and isolate the ureter(s)
  5. determine the margins of the nodule  
  6. ensure complete resection.

Excision of an RVE nodule is a technically challenging surgical procedure. Use of the robot for resection is safe and feasible when performed by a trained and experienced surgeon.

I am pleased to bring you this video, and I hope that it is helpful to your practice. 

>> Arnold P. Advincula, MD

 

 

Vidyard Video

 

Share your thoughts! Send your Letter to the Editor to [email protected]. Please include your name and the city and state in which you practice.

A rectovaginal endometriosis (RVE) is the most severe form of endometriosis. The gold standard for diagnosis is laparoscopy with histologic confirmation. A review of the literature suggests that surgery improves up to 70% of symptoms with generally favorable outcomes.

In this video, we provide a general introduction to endometriosis and a discussion of disease treatment options, ranging from hormonal suppression to radical bowel resections. We also illustrate the steps in robot-assisted laparoscopic excision of an RVE nodule:

  1. identify the borders of the rectosigmoid
  2. dissect the pararectal spaces  
  3. release the rectosigmoid from its attachment to the RVE nodule
  4. identify and isolate the ureter(s)
  5. determine the margins of the nodule  
  6. ensure complete resection.

Excision of an RVE nodule is a technically challenging surgical procedure. Use of the robot for resection is safe and feasible when performed by a trained and experienced surgeon.

I am pleased to bring you this video, and I hope that it is helpful to your practice. 

>> Arnold P. Advincula, MD

 

 

Vidyard Video

 

Share your thoughts! Send your Letter to the Editor to [email protected]. Please include your name and the city and state in which you practice.

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Tapering opioids

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The Centers for Disease Control and Prevention guideline for prescribing opioids for chronic pain released in March 2016 suggests that if “patients are found to be receiving high total daily dosages of opioids, clinicians should discuss their safety concerns with the patient [and] consider tapering to a safer dosage...”

All of us who prescribe opioids have had these discussions with patients. They are frequently fraught with hand-wringing and, all-too-often, a “steeling” for battle. We may have a general sense for what these discussions are like from the provider perspective, but what are they like for patients?

Dr. Jon O. Ebbert
Joseph W. Frank, MD, MPH, and his colleagues conducted in-person, semi-structured interviews of 24 adult primary care patients to assess patient perspectives on opioid tapering (Pain Med. 2016 Oct;17(10):1838-47). Patients were selected if they were: 1) currently on opioid medications without tapering; 2) currently tapering chronic opioid therapy (6 months or greater); and 3) discontinued chronic opioids therapy within the past 3 years.

Interestingly, patients had an overall low self-perceived risk of opioid overdose. Patients attributed reports of overdose to intent or risky behaviors. Patients rated the importance of treatment of current pain higher than the future potential risk of opioid use and had little faith in nonopioid pain management strategies. Patients reported fear of opioid withdrawal. They also reported the importance of social support and a healthy, trusting relationship with their provider for the facilitation of tapering. None of the patients reported switching providers who had recommended tapering. Patients who had tapered off opioids reported improved quality of life and a level of pain that was largely unchanged.

This work provides critical insight into the fears and reservations of patients facing the prospect of life on lower doses of opioids or life without them altogether. Addressing these fears directly may facilitate the discussions with patients when discussing the tapering of opioids.

Dr. Ebbert is professor of medicine, a general internist at the Mayo Clinic in Rochester, Minn., and a diplomate of the American Board of Addiction Medicine. The opinions expressed are those of the author and do not necessarily represent the views and opinions of the Mayo Clinic. The opinions expressed in this article should not be used to diagnose or treat any medical condition nor should they be used as a substitute for medical advice from a qualified, board-certified practicing clinician. Dr. Ebbert has no relevant financial disclosures about this article.

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The Centers for Disease Control and Prevention guideline for prescribing opioids for chronic pain released in March 2016 suggests that if “patients are found to be receiving high total daily dosages of opioids, clinicians should discuss their safety concerns with the patient [and] consider tapering to a safer dosage...”

All of us who prescribe opioids have had these discussions with patients. They are frequently fraught with hand-wringing and, all-too-often, a “steeling” for battle. We may have a general sense for what these discussions are like from the provider perspective, but what are they like for patients?

Dr. Jon O. Ebbert
Joseph W. Frank, MD, MPH, and his colleagues conducted in-person, semi-structured interviews of 24 adult primary care patients to assess patient perspectives on opioid tapering (Pain Med. 2016 Oct;17(10):1838-47). Patients were selected if they were: 1) currently on opioid medications without tapering; 2) currently tapering chronic opioid therapy (6 months or greater); and 3) discontinued chronic opioids therapy within the past 3 years.

Interestingly, patients had an overall low self-perceived risk of opioid overdose. Patients attributed reports of overdose to intent or risky behaviors. Patients rated the importance of treatment of current pain higher than the future potential risk of opioid use and had little faith in nonopioid pain management strategies. Patients reported fear of opioid withdrawal. They also reported the importance of social support and a healthy, trusting relationship with their provider for the facilitation of tapering. None of the patients reported switching providers who had recommended tapering. Patients who had tapered off opioids reported improved quality of life and a level of pain that was largely unchanged.

This work provides critical insight into the fears and reservations of patients facing the prospect of life on lower doses of opioids or life without them altogether. Addressing these fears directly may facilitate the discussions with patients when discussing the tapering of opioids.

Dr. Ebbert is professor of medicine, a general internist at the Mayo Clinic in Rochester, Minn., and a diplomate of the American Board of Addiction Medicine. The opinions expressed are those of the author and do not necessarily represent the views and opinions of the Mayo Clinic. The opinions expressed in this article should not be used to diagnose or treat any medical condition nor should they be used as a substitute for medical advice from a qualified, board-certified practicing clinician. Dr. Ebbert has no relevant financial disclosures about this article.

 

The Centers for Disease Control and Prevention guideline for prescribing opioids for chronic pain released in March 2016 suggests that if “patients are found to be receiving high total daily dosages of opioids, clinicians should discuss their safety concerns with the patient [and] consider tapering to a safer dosage...”

All of us who prescribe opioids have had these discussions with patients. They are frequently fraught with hand-wringing and, all-too-often, a “steeling” for battle. We may have a general sense for what these discussions are like from the provider perspective, but what are they like for patients?

Dr. Jon O. Ebbert
Joseph W. Frank, MD, MPH, and his colleagues conducted in-person, semi-structured interviews of 24 adult primary care patients to assess patient perspectives on opioid tapering (Pain Med. 2016 Oct;17(10):1838-47). Patients were selected if they were: 1) currently on opioid medications without tapering; 2) currently tapering chronic opioid therapy (6 months or greater); and 3) discontinued chronic opioids therapy within the past 3 years.

Interestingly, patients had an overall low self-perceived risk of opioid overdose. Patients attributed reports of overdose to intent or risky behaviors. Patients rated the importance of treatment of current pain higher than the future potential risk of opioid use and had little faith in nonopioid pain management strategies. Patients reported fear of opioid withdrawal. They also reported the importance of social support and a healthy, trusting relationship with their provider for the facilitation of tapering. None of the patients reported switching providers who had recommended tapering. Patients who had tapered off opioids reported improved quality of life and a level of pain that was largely unchanged.

This work provides critical insight into the fears and reservations of patients facing the prospect of life on lower doses of opioids or life without them altogether. Addressing these fears directly may facilitate the discussions with patients when discussing the tapering of opioids.

Dr. Ebbert is professor of medicine, a general internist at the Mayo Clinic in Rochester, Minn., and a diplomate of the American Board of Addiction Medicine. The opinions expressed are those of the author and do not necessarily represent the views and opinions of the Mayo Clinic. The opinions expressed in this article should not be used to diagnose or treat any medical condition nor should they be used as a substitute for medical advice from a qualified, board-certified practicing clinician. Dr. Ebbert has no relevant financial disclosures about this article.

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AGA Tech Summit offers packed agenda of innovation and technology

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The 2017 AGA Tech Summit, sponsored by the AGA Center for GI Innovation and Technology, promises to provide gastroenterologists and gastrointestinal surgeons with an insider’s perspective on regulators, payors, and companies in the medtech space during its 2017 session from April 12-14 in Boston. “This year’s agenda will highlight personalized diagnostics and the impact of MACRA on gastroenterology,” said Michael L. Kochman, MD, AGAF, of Penn Medicine, Philadelphia, who is executive committee chair of the center. “The intimate nature of the meeting will allow attendees to interact with fellow gastroenterologists and GI surgeons while benefiting from sessions on critical innovation and technology issues in our field.”

Development of the program started at the 2016 conference, building on that session’s highlights, as well as on the needs and interests of its attendees and speakers. “It takes a full 9 months to lock down the topics and find appropriate presenters,” explained Dr. Kochman. “The program is continually assessed and updated to keep up with medtech developments. Handpicked faculty members include prominent leaders in the medical, medtech, and regulatory communities.”

Dr. Michael L. Kochman
When asked about the summit’s highlights, Dr. Kochman cited two keynote presentations. On Wednesday night, David Friend, MD, chief transformation officer and managing director of the BDO Center for Healthcare Excellence & Innovation, will speak at a dinner for summit sponsors. Dr. Friend helps BDO’s medical device clients develop strategies for obtaining market authorization for new technologies. Thursday morning, Herbert Lerner, MD, senior director of regulatory and clinical sciences at Hogan Lovell, will speak on “21st Century Fears,” drawing on his experience as former deputy division director of reproductive, gastro-renal, and urological devices at FDA/CDRH/ODE (the Food and Drug Administration/Center for Devices and Radiological Health/Office of Drug Evaluation).

“Two important sessions demonstrate the breadth of the meeting,” stated Dr. Kochman. “This year’s Shark Tank will cover novel developments in GI medtech.” Participating companies and entrepreneurs will have 5 minutes to present their projects to an expert panel of venture capitalists, physicians, and industry executives who make acquisition decisions. “There will also be a cutting-edge session covering liquid biopsy and personalized medicine in gastroenterology,” he added. Other highlights include presentations on “The Macroeconomics of Care Delivery: MACRA and the Change to Come” and practice and device development.
 

 

The event includes a wide range of opportunities for networking with faculty and attendees, including during the breaks on both days, a Thursday night reception, and luncheons.

Summit sessions will span critical elements affecting how innovation in the GI space evolves from concept to reality. Other topics covered will include a digestive world outlook, driving innovation adoption, research updates, quality outcomes, raising capital, medtech success in GI and metabolic diseases from 2016, opportunities and challenges in personalized medicine, and improving patient outcomes via quality efforts.

Those who cannot attend the conference can look forward to “Highlights of the 2017 AGA Tech Summit,” which will be published as a supplement to GI & Hepatology News. “There will be writers in Boston attending and capturing highlights of the event sessions,” said Dr. Kochman. “AGA members will have the opportunity to experience the salient points of the presentations through this publication.”

The AGA Tech Summit will foster innovation and technology in the field of digestive health. “The keynote speakers and presenters, along with the audience’s multiple perspectives will be something we can build on to hopefully shape the future of gastroenterology,” concluded Dr. Kochman.

Dr. Kochman disclosed that he serves as a consultant for Boston Scientific Corp. and Dark Canyon Labs.

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The 2017 AGA Tech Summit, sponsored by the AGA Center for GI Innovation and Technology, promises to provide gastroenterologists and gastrointestinal surgeons with an insider’s perspective on regulators, payors, and companies in the medtech space during its 2017 session from April 12-14 in Boston. “This year’s agenda will highlight personalized diagnostics and the impact of MACRA on gastroenterology,” said Michael L. Kochman, MD, AGAF, of Penn Medicine, Philadelphia, who is executive committee chair of the center. “The intimate nature of the meeting will allow attendees to interact with fellow gastroenterologists and GI surgeons while benefiting from sessions on critical innovation and technology issues in our field.”

Development of the program started at the 2016 conference, building on that session’s highlights, as well as on the needs and interests of its attendees and speakers. “It takes a full 9 months to lock down the topics and find appropriate presenters,” explained Dr. Kochman. “The program is continually assessed and updated to keep up with medtech developments. Handpicked faculty members include prominent leaders in the medical, medtech, and regulatory communities.”

Dr. Michael L. Kochman
When asked about the summit’s highlights, Dr. Kochman cited two keynote presentations. On Wednesday night, David Friend, MD, chief transformation officer and managing director of the BDO Center for Healthcare Excellence & Innovation, will speak at a dinner for summit sponsors. Dr. Friend helps BDO’s medical device clients develop strategies for obtaining market authorization for new technologies. Thursday morning, Herbert Lerner, MD, senior director of regulatory and clinical sciences at Hogan Lovell, will speak on “21st Century Fears,” drawing on his experience as former deputy division director of reproductive, gastro-renal, and urological devices at FDA/CDRH/ODE (the Food and Drug Administration/Center for Devices and Radiological Health/Office of Drug Evaluation).

“Two important sessions demonstrate the breadth of the meeting,” stated Dr. Kochman. “This year’s Shark Tank will cover novel developments in GI medtech.” Participating companies and entrepreneurs will have 5 minutes to present their projects to an expert panel of venture capitalists, physicians, and industry executives who make acquisition decisions. “There will also be a cutting-edge session covering liquid biopsy and personalized medicine in gastroenterology,” he added. Other highlights include presentations on “The Macroeconomics of Care Delivery: MACRA and the Change to Come” and practice and device development.
 

 

The event includes a wide range of opportunities for networking with faculty and attendees, including during the breaks on both days, a Thursday night reception, and luncheons.

Summit sessions will span critical elements affecting how innovation in the GI space evolves from concept to reality. Other topics covered will include a digestive world outlook, driving innovation adoption, research updates, quality outcomes, raising capital, medtech success in GI and metabolic diseases from 2016, opportunities and challenges in personalized medicine, and improving patient outcomes via quality efforts.

Those who cannot attend the conference can look forward to “Highlights of the 2017 AGA Tech Summit,” which will be published as a supplement to GI & Hepatology News. “There will be writers in Boston attending and capturing highlights of the event sessions,” said Dr. Kochman. “AGA members will have the opportunity to experience the salient points of the presentations through this publication.”

The AGA Tech Summit will foster innovation and technology in the field of digestive health. “The keynote speakers and presenters, along with the audience’s multiple perspectives will be something we can build on to hopefully shape the future of gastroenterology,” concluded Dr. Kochman.

Dr. Kochman disclosed that he serves as a consultant for Boston Scientific Corp. and Dark Canyon Labs.

The 2017 AGA Tech Summit, sponsored by the AGA Center for GI Innovation and Technology, promises to provide gastroenterologists and gastrointestinal surgeons with an insider’s perspective on regulators, payors, and companies in the medtech space during its 2017 session from April 12-14 in Boston. “This year’s agenda will highlight personalized diagnostics and the impact of MACRA on gastroenterology,” said Michael L. Kochman, MD, AGAF, of Penn Medicine, Philadelphia, who is executive committee chair of the center. “The intimate nature of the meeting will allow attendees to interact with fellow gastroenterologists and GI surgeons while benefiting from sessions on critical innovation and technology issues in our field.”

Development of the program started at the 2016 conference, building on that session’s highlights, as well as on the needs and interests of its attendees and speakers. “It takes a full 9 months to lock down the topics and find appropriate presenters,” explained Dr. Kochman. “The program is continually assessed and updated to keep up with medtech developments. Handpicked faculty members include prominent leaders in the medical, medtech, and regulatory communities.”

Dr. Michael L. Kochman
When asked about the summit’s highlights, Dr. Kochman cited two keynote presentations. On Wednesday night, David Friend, MD, chief transformation officer and managing director of the BDO Center for Healthcare Excellence & Innovation, will speak at a dinner for summit sponsors. Dr. Friend helps BDO’s medical device clients develop strategies for obtaining market authorization for new technologies. Thursday morning, Herbert Lerner, MD, senior director of regulatory and clinical sciences at Hogan Lovell, will speak on “21st Century Fears,” drawing on his experience as former deputy division director of reproductive, gastro-renal, and urological devices at FDA/CDRH/ODE (the Food and Drug Administration/Center for Devices and Radiological Health/Office of Drug Evaluation).

“Two important sessions demonstrate the breadth of the meeting,” stated Dr. Kochman. “This year’s Shark Tank will cover novel developments in GI medtech.” Participating companies and entrepreneurs will have 5 minutes to present their projects to an expert panel of venture capitalists, physicians, and industry executives who make acquisition decisions. “There will also be a cutting-edge session covering liquid biopsy and personalized medicine in gastroenterology,” he added. Other highlights include presentations on “The Macroeconomics of Care Delivery: MACRA and the Change to Come” and practice and device development.
 

 

The event includes a wide range of opportunities for networking with faculty and attendees, including during the breaks on both days, a Thursday night reception, and luncheons.

Summit sessions will span critical elements affecting how innovation in the GI space evolves from concept to reality. Other topics covered will include a digestive world outlook, driving innovation adoption, research updates, quality outcomes, raising capital, medtech success in GI and metabolic diseases from 2016, opportunities and challenges in personalized medicine, and improving patient outcomes via quality efforts.

Those who cannot attend the conference can look forward to “Highlights of the 2017 AGA Tech Summit,” which will be published as a supplement to GI & Hepatology News. “There will be writers in Boston attending and capturing highlights of the event sessions,” said Dr. Kochman. “AGA members will have the opportunity to experience the salient points of the presentations through this publication.”

The AGA Tech Summit will foster innovation and technology in the field of digestive health. “The keynote speakers and presenters, along with the audience’s multiple perspectives will be something we can build on to hopefully shape the future of gastroenterology,” concluded Dr. Kochman.

Dr. Kochman disclosed that he serves as a consultant for Boston Scientific Corp. and Dark Canyon Labs.

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Septic shock patients suffer most from delayed antibiotics

Comment by Dr. Vera A. De Palo, MD, MBA, FCCP,
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Hospital mortality for sepsis patients was 9% more likely with each hour of delayed administration of antibiotics, and the mortality rates increased with the severity of sepsis, based on data from 35,000 randomly selected sepsis patients.

Early administration of antibiotics in sepsis cases has become accepted as a way to improve outcomes, but the benefits have not been well studied, wrote Vincent X Liu, MD, MS, of Kaiser Permanente Division of Research, Oakland, Calif., and his colleagues.

To quantify the impact of antibiotic timing on mortality rates in different types of sepsis patients, the researchers reviewed data from 35,000 adults treated for sepsis at 21 emergency departments in northern California between 2010 and 2013. The time from registration at the emergency department to administration of the first antibiotics was less than 6 hours (Am J Respir Crit Care Med. 2017 March 27. doi: 10.1164/rccm.201609-1848OC).

The overall mortality rates were 3.9%, 8.8%, and 26.0% for sepsis, severe sepsis, and septic shock, respectively. Absolute mortality increased by 0.3% for sepsis, 0.4% for severe sepsis, and 1.8% for septic shock patients after an hour’s delay in the administration of antibiotics, and the adjusted odds ratio for hospital mortality was 1.09 for each hour between patient registration and antibiotic administration. The median time to the first administration of antibiotics was 2.1 hours, ranging from 1.7 hours for septic shock patients to 2.3 hours for sepsis patients, with ceftriaxone having been the most commonly used antibiotic across all groups.

Approximately 42% of patients received one antibiotic and 43% received two antibiotics. The odds of receiving two or more antibiotics were significantly higher for septic shock patients compared with sepsis patients (72% vs. 52%, respectively).

The findings were limited by several factors, including the inability to adjust for concomitant sepsis treatments and preexisting antibiotic treatments, the researchers said.

The study results do not resolve all questions about the timing of antibiotic administration for sepsis patients, such as whether there is additional benefit to giving the medications at 2 hours rather than 3 hours or 4 hours after ED admission, the researchers noted. However, “our findings support currently held beliefs that administering early antibiotics to infected patients with systemic inflammation is beneficial for reducing mortality,” they said.

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In medicine, we strive to increase our understanding of disease states and improve outcomes for patients. This study supports the belief that timing of the admin

Dr. Vera A. De Palo
istration of antibiotics and mortality in septic shock patients are linked.

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In medicine, we strive to increase our understanding of disease states and improve outcomes for patients. This study supports the belief that timing of the admin

Dr. Vera A. De Palo
istration of antibiotics and mortality in septic shock patients are linked.

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In medicine, we strive to increase our understanding of disease states and improve outcomes for patients. This study supports the belief that timing of the admin

Dr. Vera A. De Palo
istration of antibiotics and mortality in septic shock patients are linked.

Title
Comment by Dr. Vera A. De Palo, MD, MBA, FCCP,
Comment by Dr. Vera A. De Palo, MD, MBA, FCCP,

 

Hospital mortality for sepsis patients was 9% more likely with each hour of delayed administration of antibiotics, and the mortality rates increased with the severity of sepsis, based on data from 35,000 randomly selected sepsis patients.

Early administration of antibiotics in sepsis cases has become accepted as a way to improve outcomes, but the benefits have not been well studied, wrote Vincent X Liu, MD, MS, of Kaiser Permanente Division of Research, Oakland, Calif., and his colleagues.

To quantify the impact of antibiotic timing on mortality rates in different types of sepsis patients, the researchers reviewed data from 35,000 adults treated for sepsis at 21 emergency departments in northern California between 2010 and 2013. The time from registration at the emergency department to administration of the first antibiotics was less than 6 hours (Am J Respir Crit Care Med. 2017 March 27. doi: 10.1164/rccm.201609-1848OC).

The overall mortality rates were 3.9%, 8.8%, and 26.0% for sepsis, severe sepsis, and septic shock, respectively. Absolute mortality increased by 0.3% for sepsis, 0.4% for severe sepsis, and 1.8% for septic shock patients after an hour’s delay in the administration of antibiotics, and the adjusted odds ratio for hospital mortality was 1.09 for each hour between patient registration and antibiotic administration. The median time to the first administration of antibiotics was 2.1 hours, ranging from 1.7 hours for septic shock patients to 2.3 hours for sepsis patients, with ceftriaxone having been the most commonly used antibiotic across all groups.

Approximately 42% of patients received one antibiotic and 43% received two antibiotics. The odds of receiving two or more antibiotics were significantly higher for septic shock patients compared with sepsis patients (72% vs. 52%, respectively).

The findings were limited by several factors, including the inability to adjust for concomitant sepsis treatments and preexisting antibiotic treatments, the researchers said.

The study results do not resolve all questions about the timing of antibiotic administration for sepsis patients, such as whether there is additional benefit to giving the medications at 2 hours rather than 3 hours or 4 hours after ED admission, the researchers noted. However, “our findings support currently held beliefs that administering early antibiotics to infected patients with systemic inflammation is beneficial for reducing mortality,” they said.

 

Hospital mortality for sepsis patients was 9% more likely with each hour of delayed administration of antibiotics, and the mortality rates increased with the severity of sepsis, based on data from 35,000 randomly selected sepsis patients.

Early administration of antibiotics in sepsis cases has become accepted as a way to improve outcomes, but the benefits have not been well studied, wrote Vincent X Liu, MD, MS, of Kaiser Permanente Division of Research, Oakland, Calif., and his colleagues.

To quantify the impact of antibiotic timing on mortality rates in different types of sepsis patients, the researchers reviewed data from 35,000 adults treated for sepsis at 21 emergency departments in northern California between 2010 and 2013. The time from registration at the emergency department to administration of the first antibiotics was less than 6 hours (Am J Respir Crit Care Med. 2017 March 27. doi: 10.1164/rccm.201609-1848OC).

The overall mortality rates were 3.9%, 8.8%, and 26.0% for sepsis, severe sepsis, and septic shock, respectively. Absolute mortality increased by 0.3% for sepsis, 0.4% for severe sepsis, and 1.8% for septic shock patients after an hour’s delay in the administration of antibiotics, and the adjusted odds ratio for hospital mortality was 1.09 for each hour between patient registration and antibiotic administration. The median time to the first administration of antibiotics was 2.1 hours, ranging from 1.7 hours for septic shock patients to 2.3 hours for sepsis patients, with ceftriaxone having been the most commonly used antibiotic across all groups.

Approximately 42% of patients received one antibiotic and 43% received two antibiotics. The odds of receiving two or more antibiotics were significantly higher for septic shock patients compared with sepsis patients (72% vs. 52%, respectively).

The findings were limited by several factors, including the inability to adjust for concomitant sepsis treatments and preexisting antibiotic treatments, the researchers said.

The study results do not resolve all questions about the timing of antibiotic administration for sepsis patients, such as whether there is additional benefit to giving the medications at 2 hours rather than 3 hours or 4 hours after ED admission, the researchers noted. However, “our findings support currently held beliefs that administering early antibiotics to infected patients with systemic inflammation is beneficial for reducing mortality,” they said.

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FROM THE AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

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Key clinical point: Each hour of delay in antibiotic administration increased the odds of hospital mortality in sepsis patients.

Major finding: An hour delay in antibiotic administration increased the absolute mortality by 0.3% for cases of sepsis, 0.4% for severe sepsis, and 1.8% for septic shock.

Data source: A retrospective study of 35,000 adult patients treated with a sepsis quality improvement program at 21 emergency departments in California.

Disclosures: The study was supported in part by the Permanente Medical Group and Kaiser Foundation Hospitals, the National Institute of General Medical Sciences, and the Veterans Affairs Health Services Research and Development Service.

Get on board with APMs or risk having your practice commoditized

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Gastroenterologists need to get on board with assuming risk through the adoption of advanced alternative payment methods under Medicare’s new Quality Payment Program or risk losing money through the commoditization of their services.

That’s the message Lawrence Kosinski, MD, of the Illinois Gastroenterology Group, has for his fellow gastroenterologists.
 

 

“To me, MIPS [Merit-based Incentive Payment System] is just an extension of what we were doing with PQRS and meaningful use, value-based modifiers,” Dr. Kosinski, who serves as practice councillor on the AGA Governing Board, said in an interview in advance of his presentation at the 2017 AGA Tech Summit sponsored by the AGA Center for GI Innovation and Technology.

Dr. Lawrence Kosinski

If gastroenterologists choose to stay on that path rather than accept the two-sided risk of following the APM track of the Quality Payment Program, “you are going to have commoditized services and you are going to just make less money and work for somebody else. But if you want to be in control of your own future, we have to strive to work in [the APM] direction.”

To get there, the culture of gastroenterology will need to shift.

“Our culture right now is one where we get paid for making widgets,” he said. “And the more widgets we make, the more money we make. The more colonoscopies we do, the more money we make. The more we can charge for those colonoscopies and get collected, the better things are for us.”

The future could allow gastroenterologists to charge for more and different services, he added.

“A lot of people are working to replace colonoscopies with much less expensive alternative,” Dr. Kosinski said. “So where does a gastroenterologist have a competitive advantage? It’s in the knowledge of these complex diseases that are running up the cost of health care. Over 80% of the cost of health care is for the management of chronic disease. We happen to have a very expensive set of chronic diseases that we take care of in GI, very complicated illnesses. We need to leverage that. We need to leverage the management of those patients, but we need to be able to show how our work decreases the overall cost of care so that we can get a piece of that risk premium.”

He warned: “If we don’t do that, we’re just going to be commoditized proceduralists.”

And the upside will be better reimbursements for doctors and lower overall costs for health systems.

“We may be able to increase our own reimbursement as long as we are critical in lowering the overall cost of care for the entire population,” he said.

To that end, “well-managed GI practices should be able to develop a competitive advantage in a value space to be able to supply the needed services,” he said, adding that “we’re going to have to provide value by improving quality through a focus on patient outcomes. We have to assure a new level of patient relationships and ultimately focus on lowering the cost of care for a population of patients.”

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Gastroenterologists need to get on board with assuming risk through the adoption of advanced alternative payment methods under Medicare’s new Quality Payment Program or risk losing money through the commoditization of their services.

That’s the message Lawrence Kosinski, MD, of the Illinois Gastroenterology Group, has for his fellow gastroenterologists.
 

 

“To me, MIPS [Merit-based Incentive Payment System] is just an extension of what we were doing with PQRS and meaningful use, value-based modifiers,” Dr. Kosinski, who serves as practice councillor on the AGA Governing Board, said in an interview in advance of his presentation at the 2017 AGA Tech Summit sponsored by the AGA Center for GI Innovation and Technology.

Dr. Lawrence Kosinski

If gastroenterologists choose to stay on that path rather than accept the two-sided risk of following the APM track of the Quality Payment Program, “you are going to have commoditized services and you are going to just make less money and work for somebody else. But if you want to be in control of your own future, we have to strive to work in [the APM] direction.”

To get there, the culture of gastroenterology will need to shift.

“Our culture right now is one where we get paid for making widgets,” he said. “And the more widgets we make, the more money we make. The more colonoscopies we do, the more money we make. The more we can charge for those colonoscopies and get collected, the better things are for us.”

The future could allow gastroenterologists to charge for more and different services, he added.

“A lot of people are working to replace colonoscopies with much less expensive alternative,” Dr. Kosinski said. “So where does a gastroenterologist have a competitive advantage? It’s in the knowledge of these complex diseases that are running up the cost of health care. Over 80% of the cost of health care is for the management of chronic disease. We happen to have a very expensive set of chronic diseases that we take care of in GI, very complicated illnesses. We need to leverage that. We need to leverage the management of those patients, but we need to be able to show how our work decreases the overall cost of care so that we can get a piece of that risk premium.”

He warned: “If we don’t do that, we’re just going to be commoditized proceduralists.”

And the upside will be better reimbursements for doctors and lower overall costs for health systems.

“We may be able to increase our own reimbursement as long as we are critical in lowering the overall cost of care for the entire population,” he said.

To that end, “well-managed GI practices should be able to develop a competitive advantage in a value space to be able to supply the needed services,” he said, adding that “we’re going to have to provide value by improving quality through a focus on patient outcomes. We have to assure a new level of patient relationships and ultimately focus on lowering the cost of care for a population of patients.”

Gastroenterologists need to get on board with assuming risk through the adoption of advanced alternative payment methods under Medicare’s new Quality Payment Program or risk losing money through the commoditization of their services.

That’s the message Lawrence Kosinski, MD, of the Illinois Gastroenterology Group, has for his fellow gastroenterologists.
 

 

“To me, MIPS [Merit-based Incentive Payment System] is just an extension of what we were doing with PQRS and meaningful use, value-based modifiers,” Dr. Kosinski, who serves as practice councillor on the AGA Governing Board, said in an interview in advance of his presentation at the 2017 AGA Tech Summit sponsored by the AGA Center for GI Innovation and Technology.

Dr. Lawrence Kosinski

If gastroenterologists choose to stay on that path rather than accept the two-sided risk of following the APM track of the Quality Payment Program, “you are going to have commoditized services and you are going to just make less money and work for somebody else. But if you want to be in control of your own future, we have to strive to work in [the APM] direction.”

To get there, the culture of gastroenterology will need to shift.

“Our culture right now is one where we get paid for making widgets,” he said. “And the more widgets we make, the more money we make. The more colonoscopies we do, the more money we make. The more we can charge for those colonoscopies and get collected, the better things are for us.”

The future could allow gastroenterologists to charge for more and different services, he added.

“A lot of people are working to replace colonoscopies with much less expensive alternative,” Dr. Kosinski said. “So where does a gastroenterologist have a competitive advantage? It’s in the knowledge of these complex diseases that are running up the cost of health care. Over 80% of the cost of health care is for the management of chronic disease. We happen to have a very expensive set of chronic diseases that we take care of in GI, very complicated illnesses. We need to leverage that. We need to leverage the management of those patients, but we need to be able to show how our work decreases the overall cost of care so that we can get a piece of that risk premium.”

He warned: “If we don’t do that, we’re just going to be commoditized proceduralists.”

And the upside will be better reimbursements for doctors and lower overall costs for health systems.

“We may be able to increase our own reimbursement as long as we are critical in lowering the overall cost of care for the entire population,” he said.

To that end, “well-managed GI practices should be able to develop a competitive advantage in a value space to be able to supply the needed services,” he said, adding that “we’re going to have to provide value by improving quality through a focus on patient outcomes. We have to assure a new level of patient relationships and ultimately focus on lowering the cost of care for a population of patients.”

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Hard water versus your skin

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Mon, 01/14/2019 - 10:00

 

Observational studies suggest that hard water is associated with the development of atopic dermatitis (AD). Studies of children in the United Kingdom, Spain, and Japan show the prevalence of AD is significantly higher in the highest water hardness categories than that in the lowest. Calcium cations in water can interfere with normal epidermal calcium gradients that are necessary for corneocyte development and proper stratum corneum barrier formation.

Water hardness, determined by the amount of dissolved calcium and magnesium in the water, varies by geography and mineral content of the water supply. The hardest water supply in the United States is mostly localized to the Upper Plains and Rocky Mountain areas. General guidelines for classification of waters are: 0-60 mg/L calcium carbonate (soft); 61-120 mg/L (moderately hard); 121-180 mg/L (hard); and more than 180 mg/L (very hard). In regions where there is hard water, the surfactants in soap, such as sodium dodecyl sulfate, react with the calcium and magnesium ions in hard water, resulting in precipitation of the surfactant – leaving a film of residue on the skin, shower tiles, pipes, glassware, etc.

Dr. Lily Talakoub
Dr. Lily Talakoub
Maibach et al. also described water as a contact irritant, particularly under occlusion. Skin occluded with water has increased histopathologic inflammation, scaling, and barrier breakdown. In addition to than mineral content, pH, temperature, and osmolarity can be contributing factors to the irritancy of water. However, compared with “soft water,” skin exposed to hard water has increased dilution of the natural moisturizing factors and alteration of the corneocyte layers, resulting in increased disruption of the protective epidermal barrier.

Atopic dermatitis, xerosis, and pruritus are some of the common skin reactions to hard water. Other less-well-defined effects on the skin include clogged pores and acne from surfactant residue left on the skin and altered sebum production. In addition, more surfactants or cleansers are needed to clean the skin and hair in areas with hard water because the abundant cations require a much heavier lather to dissolve.

Calcium and magnesium cations left on the skin can also form free radicals. Free radicals over time can result in collagen and elastin breakdown and in the increased prevalence of fine lines and wrinkles.

Dr. Naissan O. Wesley
Although there is no definitive solution to geographic increases of water mineral content, water softeners have grown in popularity over the last decade and in my practice are recommended to anyone with atopic dermatitis that is resistant to treatment or is recalcitrant. These home appliances work though an ion exchange system in which a resin or organic polymer replaces the magnesium and calcium in the water with sodium or potassium cations. When all the sodium or potassium ions have been replaced in the resin, the resin is then “recharged” with a solution of sodium hydroxide (lye) or potassium hydroxide. Alternative less popular softening techniques include lime softening, chelating agents, distillation, and reverse osmosis.

Hard water and geography should be considered a possible factor when assessing patients with recalcitrant eczema, pruritus, or xerosis that cannot otherwise be reversed. Water softening treatments are a simple solution in areas where the mineral content of water is elevated or the water plays a role in clinical skin disease.


 

Dr. Lily Talakoub and Dr. Naissan O. Wesley and are cocontributors to this column. Dr. Talakoub is in private practice in McLean, Va. Dr. Wesley practices dermatology in Beverly Hills, Calif. This month’s column is by Dr. Talakoub. Write to them at [email protected]. They had no relevant disclosures.



References

United States Geological Survey Water Quality Information: Water Hardness and Alkalinity.

J Am Acad Dermatol. 1987 Jun;16(6):1263-4.

Contact Dermatitis. 1996 Dec;35(6):337-43.

Lancet. 1998 Aug 15;352(9127):527-31.

Contact Dermatitis. 1999;41(6):311-4.

Environ Res. 2004 Jan;94(1):33-7.

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Observational studies suggest that hard water is associated with the development of atopic dermatitis (AD). Studies of children in the United Kingdom, Spain, and Japan show the prevalence of AD is significantly higher in the highest water hardness categories than that in the lowest. Calcium cations in water can interfere with normal epidermal calcium gradients that are necessary for corneocyte development and proper stratum corneum barrier formation.

Water hardness, determined by the amount of dissolved calcium and magnesium in the water, varies by geography and mineral content of the water supply. The hardest water supply in the United States is mostly localized to the Upper Plains and Rocky Mountain areas. General guidelines for classification of waters are: 0-60 mg/L calcium carbonate (soft); 61-120 mg/L (moderately hard); 121-180 mg/L (hard); and more than 180 mg/L (very hard). In regions where there is hard water, the surfactants in soap, such as sodium dodecyl sulfate, react with the calcium and magnesium ions in hard water, resulting in precipitation of the surfactant – leaving a film of residue on the skin, shower tiles, pipes, glassware, etc.

Dr. Lily Talakoub
Dr. Lily Talakoub
Maibach et al. also described water as a contact irritant, particularly under occlusion. Skin occluded with water has increased histopathologic inflammation, scaling, and barrier breakdown. In addition to than mineral content, pH, temperature, and osmolarity can be contributing factors to the irritancy of water. However, compared with “soft water,” skin exposed to hard water has increased dilution of the natural moisturizing factors and alteration of the corneocyte layers, resulting in increased disruption of the protective epidermal barrier.

Atopic dermatitis, xerosis, and pruritus are some of the common skin reactions to hard water. Other less-well-defined effects on the skin include clogged pores and acne from surfactant residue left on the skin and altered sebum production. In addition, more surfactants or cleansers are needed to clean the skin and hair in areas with hard water because the abundant cations require a much heavier lather to dissolve.

Calcium and magnesium cations left on the skin can also form free radicals. Free radicals over time can result in collagen and elastin breakdown and in the increased prevalence of fine lines and wrinkles.

Dr. Naissan O. Wesley
Although there is no definitive solution to geographic increases of water mineral content, water softeners have grown in popularity over the last decade and in my practice are recommended to anyone with atopic dermatitis that is resistant to treatment or is recalcitrant. These home appliances work though an ion exchange system in which a resin or organic polymer replaces the magnesium and calcium in the water with sodium or potassium cations. When all the sodium or potassium ions have been replaced in the resin, the resin is then “recharged” with a solution of sodium hydroxide (lye) or potassium hydroxide. Alternative less popular softening techniques include lime softening, chelating agents, distillation, and reverse osmosis.

Hard water and geography should be considered a possible factor when assessing patients with recalcitrant eczema, pruritus, or xerosis that cannot otherwise be reversed. Water softening treatments are a simple solution in areas where the mineral content of water is elevated or the water plays a role in clinical skin disease.


 

Dr. Lily Talakoub and Dr. Naissan O. Wesley and are cocontributors to this column. Dr. Talakoub is in private practice in McLean, Va. Dr. Wesley practices dermatology in Beverly Hills, Calif. This month’s column is by Dr. Talakoub. Write to them at [email protected]. They had no relevant disclosures.



References

United States Geological Survey Water Quality Information: Water Hardness and Alkalinity.

J Am Acad Dermatol. 1987 Jun;16(6):1263-4.

Contact Dermatitis. 1996 Dec;35(6):337-43.

Lancet. 1998 Aug 15;352(9127):527-31.

Contact Dermatitis. 1999;41(6):311-4.

Environ Res. 2004 Jan;94(1):33-7.

 

Observational studies suggest that hard water is associated with the development of atopic dermatitis (AD). Studies of children in the United Kingdom, Spain, and Japan show the prevalence of AD is significantly higher in the highest water hardness categories than that in the lowest. Calcium cations in water can interfere with normal epidermal calcium gradients that are necessary for corneocyte development and proper stratum corneum barrier formation.

Water hardness, determined by the amount of dissolved calcium and magnesium in the water, varies by geography and mineral content of the water supply. The hardest water supply in the United States is mostly localized to the Upper Plains and Rocky Mountain areas. General guidelines for classification of waters are: 0-60 mg/L calcium carbonate (soft); 61-120 mg/L (moderately hard); 121-180 mg/L (hard); and more than 180 mg/L (very hard). In regions where there is hard water, the surfactants in soap, such as sodium dodecyl sulfate, react with the calcium and magnesium ions in hard water, resulting in precipitation of the surfactant – leaving a film of residue on the skin, shower tiles, pipes, glassware, etc.

Dr. Lily Talakoub
Dr. Lily Talakoub
Maibach et al. also described water as a contact irritant, particularly under occlusion. Skin occluded with water has increased histopathologic inflammation, scaling, and barrier breakdown. In addition to than mineral content, pH, temperature, and osmolarity can be contributing factors to the irritancy of water. However, compared with “soft water,” skin exposed to hard water has increased dilution of the natural moisturizing factors and alteration of the corneocyte layers, resulting in increased disruption of the protective epidermal barrier.

Atopic dermatitis, xerosis, and pruritus are some of the common skin reactions to hard water. Other less-well-defined effects on the skin include clogged pores and acne from surfactant residue left on the skin and altered sebum production. In addition, more surfactants or cleansers are needed to clean the skin and hair in areas with hard water because the abundant cations require a much heavier lather to dissolve.

Calcium and magnesium cations left on the skin can also form free radicals. Free radicals over time can result in collagen and elastin breakdown and in the increased prevalence of fine lines and wrinkles.

Dr. Naissan O. Wesley
Although there is no definitive solution to geographic increases of water mineral content, water softeners have grown in popularity over the last decade and in my practice are recommended to anyone with atopic dermatitis that is resistant to treatment or is recalcitrant. These home appliances work though an ion exchange system in which a resin or organic polymer replaces the magnesium and calcium in the water with sodium or potassium cations. When all the sodium or potassium ions have been replaced in the resin, the resin is then “recharged” with a solution of sodium hydroxide (lye) or potassium hydroxide. Alternative less popular softening techniques include lime softening, chelating agents, distillation, and reverse osmosis.

Hard water and geography should be considered a possible factor when assessing patients with recalcitrant eczema, pruritus, or xerosis that cannot otherwise be reversed. Water softening treatments are a simple solution in areas where the mineral content of water is elevated or the water plays a role in clinical skin disease.


 

Dr. Lily Talakoub and Dr. Naissan O. Wesley and are cocontributors to this column. Dr. Talakoub is in private practice in McLean, Va. Dr. Wesley practices dermatology in Beverly Hills, Calif. This month’s column is by Dr. Talakoub. Write to them at [email protected]. They had no relevant disclosures.



References

United States Geological Survey Water Quality Information: Water Hardness and Alkalinity.

J Am Acad Dermatol. 1987 Jun;16(6):1263-4.

Contact Dermatitis. 1996 Dec;35(6):337-43.

Lancet. 1998 Aug 15;352(9127):527-31.

Contact Dermatitis. 1999;41(6):311-4.

Environ Res. 2004 Jan;94(1):33-7.

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Use ProPublica

Real-time data, transparency needed to improve safety

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Mon, 04/10/2017 - 13:38

With an increasing number of emerging technological advances in both medical devices and procedures, two factors will help improve safety and outcomes for patients: better real-time data and information transparency.

And the key to getting that data will be broader use of registries, according to Dana Telem, MD, director of the Comprehensive Hernia Program at the University of Michigan, Ann Arbor.
 

 

Dr. Telem will discuss the importance of real-time information and registries during her April 13 presentation at the 2017 AGA Tech Summit, sponsored by the AGA Center for GI Innovation and Technology.

Speaking in advance of the meeting, Dr. Telem noted that understanding value and finding potential safety issues are among the reasons for using data registries.

“I think that’s really why we need to focus on getting real-time data and that’s why I think registry efforts are so important,” she said. “What registries are really great at [is] identifying those isolated events.”

In addition, they help with another key concept she will highlight during her talk: transparency, something that is especially important as new techniques and devices are introduced.

“We understand that there are going to be early adopters, and you need to have the pioneers in order to take those next steps,” she said.

But to get the most out of those new technologies, data need to be recorded not only for short-term outcomes but over the long term as well “so that we can really assess the value of the techniques or the devices that we are putting out into the community.”

And by providing transparency on what is known, as well as unknown, it also helps patients in making their own decisions on whether to proceed with something new.

She believes that, especially when it comes to newer technologies, patients will be willing to be a part of that data collection if doctors are transparent.

“Many people are willing as long as you are honest with them,” Dr. Telem said. “I think particularly that when newer devices and techniques come out, particularly endoscopic procedures that can save them an operation, they are more willing than not, oftentimes, to do it, which is also where it gets a little bit dangerous if you are not transparent.”

But even being transparent can be a challenge.

“I think a lot of the issue that we have in health care is what type of information we are providing and how are we providing it, and is the receiver of information actually understanding what we are saying?” she pondered.

“I don’t think we know the answers to that, but I think part of the solution at least is to be as open about what we know as well as what we don’t know at the same time and let the patient make a decision based on their value system,” she continued. “A lot of times with these newer technologies or techniques, you really have to sit down with the patient and ask them about their long-term goals, what are acceptable and unacceptable outcomes.”

Recognizing the importance of data registries, in 2014 AGA launched a new initiative working as a neutral, objective broker to establish clinical research studies. Through this program, AGA collects important data to assess the value of new technologies and procedures on patient care. Ultimately, the data AGA collects will support the approval, coverage, and adoption of new technologies that demonstrate promise and merit. To learn more about AGA’s registry initiative or get involved, please contact Sonya Serra, AGA’s senior director of registry development and integrity, at [email protected].

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With an increasing number of emerging technological advances in both medical devices and procedures, two factors will help improve safety and outcomes for patients: better real-time data and information transparency.

And the key to getting that data will be broader use of registries, according to Dana Telem, MD, director of the Comprehensive Hernia Program at the University of Michigan, Ann Arbor.
 

 

Dr. Telem will discuss the importance of real-time information and registries during her April 13 presentation at the 2017 AGA Tech Summit, sponsored by the AGA Center for GI Innovation and Technology.

Speaking in advance of the meeting, Dr. Telem noted that understanding value and finding potential safety issues are among the reasons for using data registries.

“I think that’s really why we need to focus on getting real-time data and that’s why I think registry efforts are so important,” she said. “What registries are really great at [is] identifying those isolated events.”

In addition, they help with another key concept she will highlight during her talk: transparency, something that is especially important as new techniques and devices are introduced.

“We understand that there are going to be early adopters, and you need to have the pioneers in order to take those next steps,” she said.

But to get the most out of those new technologies, data need to be recorded not only for short-term outcomes but over the long term as well “so that we can really assess the value of the techniques or the devices that we are putting out into the community.”

And by providing transparency on what is known, as well as unknown, it also helps patients in making their own decisions on whether to proceed with something new.

She believes that, especially when it comes to newer technologies, patients will be willing to be a part of that data collection if doctors are transparent.

“Many people are willing as long as you are honest with them,” Dr. Telem said. “I think particularly that when newer devices and techniques come out, particularly endoscopic procedures that can save them an operation, they are more willing than not, oftentimes, to do it, which is also where it gets a little bit dangerous if you are not transparent.”

But even being transparent can be a challenge.

“I think a lot of the issue that we have in health care is what type of information we are providing and how are we providing it, and is the receiver of information actually understanding what we are saying?” she pondered.

“I don’t think we know the answers to that, but I think part of the solution at least is to be as open about what we know as well as what we don’t know at the same time and let the patient make a decision based on their value system,” she continued. “A lot of times with these newer technologies or techniques, you really have to sit down with the patient and ask them about their long-term goals, what are acceptable and unacceptable outcomes.”

Recognizing the importance of data registries, in 2014 AGA launched a new initiative working as a neutral, objective broker to establish clinical research studies. Through this program, AGA collects important data to assess the value of new technologies and procedures on patient care. Ultimately, the data AGA collects will support the approval, coverage, and adoption of new technologies that demonstrate promise and merit. To learn more about AGA’s registry initiative or get involved, please contact Sonya Serra, AGA’s senior director of registry development and integrity, at [email protected].

With an increasing number of emerging technological advances in both medical devices and procedures, two factors will help improve safety and outcomes for patients: better real-time data and information transparency.

And the key to getting that data will be broader use of registries, according to Dana Telem, MD, director of the Comprehensive Hernia Program at the University of Michigan, Ann Arbor.
 

 

Dr. Telem will discuss the importance of real-time information and registries during her April 13 presentation at the 2017 AGA Tech Summit, sponsored by the AGA Center for GI Innovation and Technology.

Speaking in advance of the meeting, Dr. Telem noted that understanding value and finding potential safety issues are among the reasons for using data registries.

“I think that’s really why we need to focus on getting real-time data and that’s why I think registry efforts are so important,” she said. “What registries are really great at [is] identifying those isolated events.”

In addition, they help with another key concept she will highlight during her talk: transparency, something that is especially important as new techniques and devices are introduced.

“We understand that there are going to be early adopters, and you need to have the pioneers in order to take those next steps,” she said.

But to get the most out of those new technologies, data need to be recorded not only for short-term outcomes but over the long term as well “so that we can really assess the value of the techniques or the devices that we are putting out into the community.”

And by providing transparency on what is known, as well as unknown, it also helps patients in making their own decisions on whether to proceed with something new.

She believes that, especially when it comes to newer technologies, patients will be willing to be a part of that data collection if doctors are transparent.

“Many people are willing as long as you are honest with them,” Dr. Telem said. “I think particularly that when newer devices and techniques come out, particularly endoscopic procedures that can save them an operation, they are more willing than not, oftentimes, to do it, which is also where it gets a little bit dangerous if you are not transparent.”

But even being transparent can be a challenge.

“I think a lot of the issue that we have in health care is what type of information we are providing and how are we providing it, and is the receiver of information actually understanding what we are saying?” she pondered.

“I don’t think we know the answers to that, but I think part of the solution at least is to be as open about what we know as well as what we don’t know at the same time and let the patient make a decision based on their value system,” she continued. “A lot of times with these newer technologies or techniques, you really have to sit down with the patient and ask them about their long-term goals, what are acceptable and unacceptable outcomes.”

Recognizing the importance of data registries, in 2014 AGA launched a new initiative working as a neutral, objective broker to establish clinical research studies. Through this program, AGA collects important data to assess the value of new technologies and procedures on patient care. Ultimately, the data AGA collects will support the approval, coverage, and adoption of new technologies that demonstrate promise and merit. To learn more about AGA’s registry initiative or get involved, please contact Sonya Serra, AGA’s senior director of registry development and integrity, at [email protected].

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Physicians favor ACOG mammography recommendations

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Thu, 12/15/2022 - 17:54

 

Primary care physicians tend to follow breast cancer screening recommendations from the American Congress of Obstetricians and Gynecologists, according to findings from a recent survey.

The American Congress of Obstetricians and Gynecologists (ACOG), the American Cancer Society (ACS), and the U.S. Preventive Services Task Force (USPSTF) offer conflicting guidelines on the optimal time to initiate and discontinue screening mammography, as well as the optimal screening interval. ACOG recommends annual screening for women aged 40 and older, while the ACS advises annual screening at age 45, and the USPSTF calls for biennial mammograms starting at age 50, though all three organizations stress individualized management.

Catherine Yeulet/Thinkstock
Researchers examined which set of guidelines hold sway in real-world practice using surveys mailed to a nationally representative random sample of 2,000 physicians in the American Medical Association’s Physician Master File. The survey asked what doctors typically recommended regarding routine screening mammography for women in different age groups who had no family history and no previous breast issues. The survey also asked which organization’s screening recommendations they trusted most, Archana Radhakrishnan, MD, of the division of general internal medicine, Johns Hopkins University, Baltimore, and her associates reported in a Research Letter in JAMA Internal Medicine (2017 April 10. doi: 10.1001/jamainternmed.2017.0453).

There were 871 respondents, including family medicine/general practice physicians (44.2%), internists (29.7%), and gynecologists (26.1%). The average age of the respondents was 53 years, and more than half of them had been in practice for more than 20 years. A slight majority (55%) were men, and most (71%) were white.

A total of 26.0% of the respondents said they trusted ACOG screening guidelines the most, 23.8% said they trusted ACS guidelines, and 22.9% said they trusted USPSTF guidelines the most.

In total, 81% of physicians recommended screening to women aged 40-44 years, 88% recommended screening to women aged 45-49 years, and 67% recommended screening for women 75 years or older. Among physicians who recommended screening, most recommended annual exams.

These findings show that physicians differ sharply in their adherence to practice guidelines. The results also “provide an important benchmark as guidelines continue evolving, and underscore the need to delineate barriers and facilitators to implementing guidelines in clinical practice,” the researchers wrote.

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Primary care physicians tend to follow breast cancer screening recommendations from the American Congress of Obstetricians and Gynecologists, according to findings from a recent survey.

The American Congress of Obstetricians and Gynecologists (ACOG), the American Cancer Society (ACS), and the U.S. Preventive Services Task Force (USPSTF) offer conflicting guidelines on the optimal time to initiate and discontinue screening mammography, as well as the optimal screening interval. ACOG recommends annual screening for women aged 40 and older, while the ACS advises annual screening at age 45, and the USPSTF calls for biennial mammograms starting at age 50, though all three organizations stress individualized management.

Catherine Yeulet/Thinkstock
Researchers examined which set of guidelines hold sway in real-world practice using surveys mailed to a nationally representative random sample of 2,000 physicians in the American Medical Association’s Physician Master File. The survey asked what doctors typically recommended regarding routine screening mammography for women in different age groups who had no family history and no previous breast issues. The survey also asked which organization’s screening recommendations they trusted most, Archana Radhakrishnan, MD, of the division of general internal medicine, Johns Hopkins University, Baltimore, and her associates reported in a Research Letter in JAMA Internal Medicine (2017 April 10. doi: 10.1001/jamainternmed.2017.0453).

There were 871 respondents, including family medicine/general practice physicians (44.2%), internists (29.7%), and gynecologists (26.1%). The average age of the respondents was 53 years, and more than half of them had been in practice for more than 20 years. A slight majority (55%) were men, and most (71%) were white.

A total of 26.0% of the respondents said they trusted ACOG screening guidelines the most, 23.8% said they trusted ACS guidelines, and 22.9% said they trusted USPSTF guidelines the most.

In total, 81% of physicians recommended screening to women aged 40-44 years, 88% recommended screening to women aged 45-49 years, and 67% recommended screening for women 75 years or older. Among physicians who recommended screening, most recommended annual exams.

These findings show that physicians differ sharply in their adherence to practice guidelines. The results also “provide an important benchmark as guidelines continue evolving, and underscore the need to delineate barriers and facilitators to implementing guidelines in clinical practice,” the researchers wrote.

 

Primary care physicians tend to follow breast cancer screening recommendations from the American Congress of Obstetricians and Gynecologists, according to findings from a recent survey.

The American Congress of Obstetricians and Gynecologists (ACOG), the American Cancer Society (ACS), and the U.S. Preventive Services Task Force (USPSTF) offer conflicting guidelines on the optimal time to initiate and discontinue screening mammography, as well as the optimal screening interval. ACOG recommends annual screening for women aged 40 and older, while the ACS advises annual screening at age 45, and the USPSTF calls for biennial mammograms starting at age 50, though all three organizations stress individualized management.

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Researchers examined which set of guidelines hold sway in real-world practice using surveys mailed to a nationally representative random sample of 2,000 physicians in the American Medical Association’s Physician Master File. The survey asked what doctors typically recommended regarding routine screening mammography for women in different age groups who had no family history and no previous breast issues. The survey also asked which organization’s screening recommendations they trusted most, Archana Radhakrishnan, MD, of the division of general internal medicine, Johns Hopkins University, Baltimore, and her associates reported in a Research Letter in JAMA Internal Medicine (2017 April 10. doi: 10.1001/jamainternmed.2017.0453).

There were 871 respondents, including family medicine/general practice physicians (44.2%), internists (29.7%), and gynecologists (26.1%). The average age of the respondents was 53 years, and more than half of them had been in practice for more than 20 years. A slight majority (55%) were men, and most (71%) were white.

A total of 26.0% of the respondents said they trusted ACOG screening guidelines the most, 23.8% said they trusted ACS guidelines, and 22.9% said they trusted USPSTF guidelines the most.

In total, 81% of physicians recommended screening to women aged 40-44 years, 88% recommended screening to women aged 45-49 years, and 67% recommended screening for women 75 years or older. Among physicians who recommended screening, most recommended annual exams.

These findings show that physicians differ sharply in their adherence to practice guidelines. The results also “provide an important benchmark as guidelines continue evolving, and underscore the need to delineate barriers and facilitators to implementing guidelines in clinical practice,” the researchers wrote.

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Key clinical point: Most physicians recommended breast cancer screening to women ages 40-44 years.

Major finding: Across physicians groups, 81% of respondents recommended screening women aged 40-44 years.

Data source: An analysis of survey responses regarding breast cancer care from a nationally representative sample of 871 family/general medicine physicians, internists, and gynecologists.

Disclosures: The researchers reported having no conflicts of interest.

Obesity in women with RA greatly influences CRP levels

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Obesity is associated with elevated C-reactive protein levels among women with rheumatoid arthritis, but this elevation reflects higher fat mass rather than RA disease activity, according to a report published online April 10 in Arthritis Care & Research.

The study findings suggest that C-reactive protein (CRP) results should be interpreted with caution among obese women with RA, noted Michael D. George, MD, of the division of rheumatology at the University of Pennsylvania, Philadelphia, and his associates.

Monkeybusinessimages/Thinkstock
A similar link has already been noted between obesity and elevated levels of inflammatory biomarkers, including CRP, among people in the general population, indicating that adiposity can skew the test results of these biomarkers and suggest that inflammatory disease is more severe than it actually is. Yet “there is surprisingly little recognition of this issue among practicing clinicians,” Dr. George and his colleagues wrote.

To examine possible associations between body mass index and inflammatory markers in RA, the investigators performed a secondary analysis of data from 451 adult RA patients in three cross-sectional cohorts and 1,652 RA patients in the longitudinal Veterans Affairs Rheumatoid Arthritis Registry cohort. The investigators compared these findings with those of about 21,000 control subjects from the general population who were assessed in the 2007-2010 and 1971-1974 National Health and Nutrition Examination Survey programs.

Among women with RA, obesity was associated with elevated CRP independently of other measures of disease activity, including swollen joint count, tender joint count, and global scores of inflammation. A “strikingly similar association” was seen in the control population. This indicates that the high CRP values in obese women with RA “are not reflective of greater RA activity but rather are an expected phenomenon related to adiposity,” Dr. George and his associates said (Arthritis Care Res. 2017 Apr 10. doi: 10.1002/acr.23229).

In contrast, obesity in men with RA did not correlate with elevated CRP levels. In fact, underweight men with RA tended to have significantly higher CRP than that of normal-weight and obese men. “It was beyond the scope of this study to fully evaluate the complex relationship between RA disease activity, disease severity, weight loss, frailty, comorbidities, advancing age, and other factors that might contribute to higher levels of systemic inflammation in low-BMI men,” the investigators noted.

The National Institutes of Health, the Rheumatology Research Foundation, the U.S. Department of Veterans Affairs, the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and the National Institute of General Medical Sciences supported the work. Dr. George reported having no relevant disclosures; his associates reported ties to Pfizer, Novartis, and Amgen.

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Obesity is associated with elevated C-reactive protein levels among women with rheumatoid arthritis, but this elevation reflects higher fat mass rather than RA disease activity, according to a report published online April 10 in Arthritis Care & Research.

The study findings suggest that C-reactive protein (CRP) results should be interpreted with caution among obese women with RA, noted Michael D. George, MD, of the division of rheumatology at the University of Pennsylvania, Philadelphia, and his associates.

Monkeybusinessimages/Thinkstock
A similar link has already been noted between obesity and elevated levels of inflammatory biomarkers, including CRP, among people in the general population, indicating that adiposity can skew the test results of these biomarkers and suggest that inflammatory disease is more severe than it actually is. Yet “there is surprisingly little recognition of this issue among practicing clinicians,” Dr. George and his colleagues wrote.

To examine possible associations between body mass index and inflammatory markers in RA, the investigators performed a secondary analysis of data from 451 adult RA patients in three cross-sectional cohorts and 1,652 RA patients in the longitudinal Veterans Affairs Rheumatoid Arthritis Registry cohort. The investigators compared these findings with those of about 21,000 control subjects from the general population who were assessed in the 2007-2010 and 1971-1974 National Health and Nutrition Examination Survey programs.

Among women with RA, obesity was associated with elevated CRP independently of other measures of disease activity, including swollen joint count, tender joint count, and global scores of inflammation. A “strikingly similar association” was seen in the control population. This indicates that the high CRP values in obese women with RA “are not reflective of greater RA activity but rather are an expected phenomenon related to adiposity,” Dr. George and his associates said (Arthritis Care Res. 2017 Apr 10. doi: 10.1002/acr.23229).

In contrast, obesity in men with RA did not correlate with elevated CRP levels. In fact, underweight men with RA tended to have significantly higher CRP than that of normal-weight and obese men. “It was beyond the scope of this study to fully evaluate the complex relationship between RA disease activity, disease severity, weight loss, frailty, comorbidities, advancing age, and other factors that might contribute to higher levels of systemic inflammation in low-BMI men,” the investigators noted.

The National Institutes of Health, the Rheumatology Research Foundation, the U.S. Department of Veterans Affairs, the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and the National Institute of General Medical Sciences supported the work. Dr. George reported having no relevant disclosures; his associates reported ties to Pfizer, Novartis, and Amgen.

 

Obesity is associated with elevated C-reactive protein levels among women with rheumatoid arthritis, but this elevation reflects higher fat mass rather than RA disease activity, according to a report published online April 10 in Arthritis Care & Research.

The study findings suggest that C-reactive protein (CRP) results should be interpreted with caution among obese women with RA, noted Michael D. George, MD, of the division of rheumatology at the University of Pennsylvania, Philadelphia, and his associates.

Monkeybusinessimages/Thinkstock
A similar link has already been noted between obesity and elevated levels of inflammatory biomarkers, including CRP, among people in the general population, indicating that adiposity can skew the test results of these biomarkers and suggest that inflammatory disease is more severe than it actually is. Yet “there is surprisingly little recognition of this issue among practicing clinicians,” Dr. George and his colleagues wrote.

To examine possible associations between body mass index and inflammatory markers in RA, the investigators performed a secondary analysis of data from 451 adult RA patients in three cross-sectional cohorts and 1,652 RA patients in the longitudinal Veterans Affairs Rheumatoid Arthritis Registry cohort. The investigators compared these findings with those of about 21,000 control subjects from the general population who were assessed in the 2007-2010 and 1971-1974 National Health and Nutrition Examination Survey programs.

Among women with RA, obesity was associated with elevated CRP independently of other measures of disease activity, including swollen joint count, tender joint count, and global scores of inflammation. A “strikingly similar association” was seen in the control population. This indicates that the high CRP values in obese women with RA “are not reflective of greater RA activity but rather are an expected phenomenon related to adiposity,” Dr. George and his associates said (Arthritis Care Res. 2017 Apr 10. doi: 10.1002/acr.23229).

In contrast, obesity in men with RA did not correlate with elevated CRP levels. In fact, underweight men with RA tended to have significantly higher CRP than that of normal-weight and obese men. “It was beyond the scope of this study to fully evaluate the complex relationship between RA disease activity, disease severity, weight loss, frailty, comorbidities, advancing age, and other factors that might contribute to higher levels of systemic inflammation in low-BMI men,” the investigators noted.

The National Institutes of Health, the Rheumatology Research Foundation, the U.S. Department of Veterans Affairs, the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and the National Institute of General Medical Sciences supported the work. Dr. George reported having no relevant disclosures; his associates reported ties to Pfizer, Novartis, and Amgen.

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Key clinical point: Obesity is associated with elevated CRP levels in women with RA, but this elevation reflects higher fat mass rather than RA disease activity.

Major finding: Among women with RA, obesity was associated with elevated CRP independently of other measures of disease activity, including swollen joint count, tender joint count, and global scores of inflammation.

Data source: A secondary analysis of data from cross-sectional and longitudinal cohort studies involving 2,103 adults with RA.

Disclosures: The National Institutes of Health, the Rheumatology Research Foundation, the U.S. Department of Veterans Affairs, the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and the National Institute of General Medical Sciences supported the work. Dr. George reported having no relevant disclosures; his associates reported ties to Pfizer, Novartis, and Amgen.

DNRs affect residents’ patient care decisions

Patient care should include patient’s cares
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Sat, 12/08/2018 - 14:03

 

Internal medicine residents reported being less likely to consider certain aggressive interventions outside of CPR on patients with do not resuscitate (DNR) and do not intubate (DNI) orders, according to a study.

These findings have researchers worried about a trend of doctors ignoring patient preferences, especially those who may have DNRs but do not want to ignore other treatment options, according to Elizabeth K. Stevenson, MD, of the Division of Pulmonary and Critical Care Medicine, North Shore Medical Center, Salem, Mass., and her colleagues.

Daisy-Daisy/Thinkstock


“DNR/DNI patients were less likely to receive many invasive procedures, surgical consultations, or transfer to the ICU,” wrote Dr. Stevenson and her colleagues. “[D]ecisions to withhold many types of care not specified in DNR/DNI orders is concerning, given that the majority of patients with a DNR/DNI status in registry studies indicated they would accept other interventions beyond CPR and intubation.”

Researchers surveyed 553 internal medicine residents in the United States using an Internet survey that presented four vignettes describing clinical situations. Participants were asked to rank how likely they would be to employ listed intervention methods, from “strongly agree” to “strongly disagree,” in each scenario (Ann Am Thorac Soc. 2017, Apr;14[4]:536-42).

Two different versions of the survey were randomly assigned, varying only in terms of which vignettes included patients with a DNR/DNI order.

Of the interventions listed for each scenario, decisions to transfer patients to the intensive care unit and suggest surgery consultations showed the strongest association with code status.

“Residents were significantly less likely to indicate they would provide invasive procedures (including central venous catheter placement, esophagogastroduodenoscopy, colonoscopy, bronchoscopy, dialysis, and surgery consultation) to patients who had a status of DNR/DNI compared with Full Code,” the investigators noted. “In contrast, decisions to pursue noninvasive diagnostic or therapeutic interventions (CT scans, administration of oxygen or intravenous fluids, blood cultures, and initiation of anticoagulation) did not significantly differ by patient code status, with high levels of use across all vignettes.”

In one vignette involving surgical consultation for an 80-year-old woman with septic shock secondary to Clostridium difficile infection, 89.1% of residents recommended a consult for full-care patients, while 77.7% recommended one for a patient with a DNR/DNI (P = .0008).

Despite these findings, 94%-96% of participants reported willingness to consult with patients on their preferences before treatment decisions, which Dr. Stevenson and her peers found somewhat comforting, although it did not completely assuage them.

“Although the ideal approach would be to have more comprehensive discussion and documentation of patients’ goals of care in the outpatient setting, realistically, many patients will neither have had such discussions nor [have] completed advance directives before hospitalization,” investigators wrote.

The study was limited by the size of the sample, which numbered approximately 2% of the active internal medicine residents in the United States. The researchers recognized that these scenarios were theoretical, and that practicing physicians may act differently when faced with a medical situation in real life. The study also was limited by the concentration of respondents within a single program, as shared experiences or teachers may cause similar responses to theoretical situations, they wrote.

One of the study’s authors reports grants from the National Institutes of Health. The other investigators report no relevant financial disclosures.

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End-of-life treatment usually should be based on the preferences of the patients and how aggressive they want their physicians to be. Yet the study by Dr. Stevenson et al. shows that decisions in types of care are more often being based on the preferences of the doctors, which is very concerning. Engaging patients in a high-quality discussion of options and care preferences is an essential part of end-of-life treatment, and this trend of physician-attributable variation shows a level of paternalism that has no place in this type of care, and could lead to dire results for patients. For example, 72% of residents in one of the theoretical situations chose to intervene with dialysis in a full-code patient, while only 38% chose to do so for patients with a DNR. While the situations are theoretical, these findings uncover a disregard for patients’ autonomy in decisions about their own care. Since patients are unable to choose their own residents and many residents will not have the opportunity to consult with every patient, DNR patients are certainly vulnerable to the possibility of being assessed for treatment based on their code status. Residents are the future of medicine, and must be trained out of this habit so that patients’ preferences are not overlooked.
 

Joanna L. Hart, MD, is a research fellow in the Pulmonary, Allergy, and Critical Care Division, and the Palliative and Advanced Illness Research Center, University of Pennsylvania, Philadelphia. Meeta Prasad Kerlin, MD, MSCE, is the associate program director at the same institution. They had not disclosures. Their comments are in an editorial (Ann Am Thorac Soc. 2017 Apr;14[4]:491-2).

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End-of-life treatment usually should be based on the preferences of the patients and how aggressive they want their physicians to be. Yet the study by Dr. Stevenson et al. shows that decisions in types of care are more often being based on the preferences of the doctors, which is very concerning. Engaging patients in a high-quality discussion of options and care preferences is an essential part of end-of-life treatment, and this trend of physician-attributable variation shows a level of paternalism that has no place in this type of care, and could lead to dire results for patients. For example, 72% of residents in one of the theoretical situations chose to intervene with dialysis in a full-code patient, while only 38% chose to do so for patients with a DNR. While the situations are theoretical, these findings uncover a disregard for patients’ autonomy in decisions about their own care. Since patients are unable to choose their own residents and many residents will not have the opportunity to consult with every patient, DNR patients are certainly vulnerable to the possibility of being assessed for treatment based on their code status. Residents are the future of medicine, and must be trained out of this habit so that patients’ preferences are not overlooked.
 

Joanna L. Hart, MD, is a research fellow in the Pulmonary, Allergy, and Critical Care Division, and the Palliative and Advanced Illness Research Center, University of Pennsylvania, Philadelphia. Meeta Prasad Kerlin, MD, MSCE, is the associate program director at the same institution. They had not disclosures. Their comments are in an editorial (Ann Am Thorac Soc. 2017 Apr;14[4]:491-2).

Body

 

End-of-life treatment usually should be based on the preferences of the patients and how aggressive they want their physicians to be. Yet the study by Dr. Stevenson et al. shows that decisions in types of care are more often being based on the preferences of the doctors, which is very concerning. Engaging patients in a high-quality discussion of options and care preferences is an essential part of end-of-life treatment, and this trend of physician-attributable variation shows a level of paternalism that has no place in this type of care, and could lead to dire results for patients. For example, 72% of residents in one of the theoretical situations chose to intervene with dialysis in a full-code patient, while only 38% chose to do so for patients with a DNR. While the situations are theoretical, these findings uncover a disregard for patients’ autonomy in decisions about their own care. Since patients are unable to choose their own residents and many residents will not have the opportunity to consult with every patient, DNR patients are certainly vulnerable to the possibility of being assessed for treatment based on their code status. Residents are the future of medicine, and must be trained out of this habit so that patients’ preferences are not overlooked.
 

Joanna L. Hart, MD, is a research fellow in the Pulmonary, Allergy, and Critical Care Division, and the Palliative and Advanced Illness Research Center, University of Pennsylvania, Philadelphia. Meeta Prasad Kerlin, MD, MSCE, is the associate program director at the same institution. They had not disclosures. Their comments are in an editorial (Ann Am Thorac Soc. 2017 Apr;14[4]:491-2).

Title
Patient care should include patient’s cares
Patient care should include patient’s cares

 

Internal medicine residents reported being less likely to consider certain aggressive interventions outside of CPR on patients with do not resuscitate (DNR) and do not intubate (DNI) orders, according to a study.

These findings have researchers worried about a trend of doctors ignoring patient preferences, especially those who may have DNRs but do not want to ignore other treatment options, according to Elizabeth K. Stevenson, MD, of the Division of Pulmonary and Critical Care Medicine, North Shore Medical Center, Salem, Mass., and her colleagues.

Daisy-Daisy/Thinkstock


“DNR/DNI patients were less likely to receive many invasive procedures, surgical consultations, or transfer to the ICU,” wrote Dr. Stevenson and her colleagues. “[D]ecisions to withhold many types of care not specified in DNR/DNI orders is concerning, given that the majority of patients with a DNR/DNI status in registry studies indicated they would accept other interventions beyond CPR and intubation.”

Researchers surveyed 553 internal medicine residents in the United States using an Internet survey that presented four vignettes describing clinical situations. Participants were asked to rank how likely they would be to employ listed intervention methods, from “strongly agree” to “strongly disagree,” in each scenario (Ann Am Thorac Soc. 2017, Apr;14[4]:536-42).

Two different versions of the survey were randomly assigned, varying only in terms of which vignettes included patients with a DNR/DNI order.

Of the interventions listed for each scenario, decisions to transfer patients to the intensive care unit and suggest surgery consultations showed the strongest association with code status.

“Residents were significantly less likely to indicate they would provide invasive procedures (including central venous catheter placement, esophagogastroduodenoscopy, colonoscopy, bronchoscopy, dialysis, and surgery consultation) to patients who had a status of DNR/DNI compared with Full Code,” the investigators noted. “In contrast, decisions to pursue noninvasive diagnostic or therapeutic interventions (CT scans, administration of oxygen or intravenous fluids, blood cultures, and initiation of anticoagulation) did not significantly differ by patient code status, with high levels of use across all vignettes.”

In one vignette involving surgical consultation for an 80-year-old woman with septic shock secondary to Clostridium difficile infection, 89.1% of residents recommended a consult for full-care patients, while 77.7% recommended one for a patient with a DNR/DNI (P = .0008).

Despite these findings, 94%-96% of participants reported willingness to consult with patients on their preferences before treatment decisions, which Dr. Stevenson and her peers found somewhat comforting, although it did not completely assuage them.

“Although the ideal approach would be to have more comprehensive discussion and documentation of patients’ goals of care in the outpatient setting, realistically, many patients will neither have had such discussions nor [have] completed advance directives before hospitalization,” investigators wrote.

The study was limited by the size of the sample, which numbered approximately 2% of the active internal medicine residents in the United States. The researchers recognized that these scenarios were theoretical, and that practicing physicians may act differently when faced with a medical situation in real life. The study also was limited by the concentration of respondents within a single program, as shared experiences or teachers may cause similar responses to theoretical situations, they wrote.

One of the study’s authors reports grants from the National Institutes of Health. The other investigators report no relevant financial disclosures.

 

Internal medicine residents reported being less likely to consider certain aggressive interventions outside of CPR on patients with do not resuscitate (DNR) and do not intubate (DNI) orders, according to a study.

These findings have researchers worried about a trend of doctors ignoring patient preferences, especially those who may have DNRs but do not want to ignore other treatment options, according to Elizabeth K. Stevenson, MD, of the Division of Pulmonary and Critical Care Medicine, North Shore Medical Center, Salem, Mass., and her colleagues.

Daisy-Daisy/Thinkstock


“DNR/DNI patients were less likely to receive many invasive procedures, surgical consultations, or transfer to the ICU,” wrote Dr. Stevenson and her colleagues. “[D]ecisions to withhold many types of care not specified in DNR/DNI orders is concerning, given that the majority of patients with a DNR/DNI status in registry studies indicated they would accept other interventions beyond CPR and intubation.”

Researchers surveyed 553 internal medicine residents in the United States using an Internet survey that presented four vignettes describing clinical situations. Participants were asked to rank how likely they would be to employ listed intervention methods, from “strongly agree” to “strongly disagree,” in each scenario (Ann Am Thorac Soc. 2017, Apr;14[4]:536-42).

Two different versions of the survey were randomly assigned, varying only in terms of which vignettes included patients with a DNR/DNI order.

Of the interventions listed for each scenario, decisions to transfer patients to the intensive care unit and suggest surgery consultations showed the strongest association with code status.

“Residents were significantly less likely to indicate they would provide invasive procedures (including central venous catheter placement, esophagogastroduodenoscopy, colonoscopy, bronchoscopy, dialysis, and surgery consultation) to patients who had a status of DNR/DNI compared with Full Code,” the investigators noted. “In contrast, decisions to pursue noninvasive diagnostic or therapeutic interventions (CT scans, administration of oxygen or intravenous fluids, blood cultures, and initiation of anticoagulation) did not significantly differ by patient code status, with high levels of use across all vignettes.”

In one vignette involving surgical consultation for an 80-year-old woman with septic shock secondary to Clostridium difficile infection, 89.1% of residents recommended a consult for full-care patients, while 77.7% recommended one for a patient with a DNR/DNI (P = .0008).

Despite these findings, 94%-96% of participants reported willingness to consult with patients on their preferences before treatment decisions, which Dr. Stevenson and her peers found somewhat comforting, although it did not completely assuage them.

“Although the ideal approach would be to have more comprehensive discussion and documentation of patients’ goals of care in the outpatient setting, realistically, many patients will neither have had such discussions nor [have] completed advance directives before hospitalization,” investigators wrote.

The study was limited by the size of the sample, which numbered approximately 2% of the active internal medicine residents in the United States. The researchers recognized that these scenarios were theoretical, and that practicing physicians may act differently when faced with a medical situation in real life. The study also was limited by the concentration of respondents within a single program, as shared experiences or teachers may cause similar responses to theoretical situations, they wrote.

One of the study’s authors reports grants from the National Institutes of Health. The other investigators report no relevant financial disclosures.

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Key clinical point: Residents’ decisions for aggressive treatments are influenced by the presence of DNRs.

Major finding: Among 553 residents, patient code status was associated with invasive care decisions beyond intubation and CPR, especially transfers to the intensive care unit.

Data source: Randomized, cross-sectional Internet survey containing four clinical situations disseminated among internal medicine residents across the United States.

Disclosures: One of the study’s authors reports grants from the National Institutes of Health. The other investigators report no relevant financial disclosures.