Drug Therapy

Amir K. Jaffer, MD
Medical Director, The Internal Medicine Preoperative Assessment Consultation and Treatment (IMPACT) Center and the Anticoagulation Clinic, Section of Hospital and Preoperative Medicine, Department of General Internal Medicine, The Cleveland Clinic

Daniel J. Brotman, MD
Section of Hospital and Preoperative Medicine, Department of General Internal Medicine, The Cleveland Clinic

Nkem Chukwumerije, MD
Kaiser Permanente Medical Center, Panorama, CA

Address: Amir K. Jaffer, MD, Department of General Internal Medicine, A72, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail: [email protected]

Dr. Jaffer has indicated that he has received grant or research support from Astra Zeneca, serves as a consultant for Aventis and Astra Zeneca, and is on the speakers’ bureau of Aventis.

This paper discusses therapies that are experimental or are not approved by the US Food and Drug Administration for the use under discussion.

Amir K. Jaffer, MD
Medical Director, The Internal Medicine Preoperative Assessment Consultation and Treatment (IMPACT) Center and the Anticoagulation Clinic, Section of Hospital and Preoperative Medicine, Department of General Internal Medicine, The Cleveland Clinic

Daniel J. Brotman, MD
Section of Hospital and Preoperative Medicine, Department of General Internal Medicine, The Cleveland Clinic

Nkem Chukwumerije, MD
Kaiser Permanente Medical Center, Panorama, CA

Address: Amir K. Jaffer, MD, Department of General Internal Medicine, A72, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail: [email protected]

Dr. Jaffer has indicated that he has received grant or research support from Astra Zeneca, serves as a consultant for Aventis and Astra Zeneca, and is on the speakers’ bureau of Aventis.

This paper discusses therapies that are experimental or are not approved by the US Food and Drug Administration for the use under discussion.

Amir K. Jaffer, MD
Medical Director, The Internal Medicine Preoperative Assessment Consultation and Treatment (IMPACT) Center and the Anticoagulation Clinic, Section of Hospital and Preoperative Medicine, Department of General Internal Medicine, The Cleveland Clinic

Daniel J. Brotman, MD
Section of Hospital and Preoperative Medicine, Department of General Internal Medicine, The Cleveland Clinic

Nkem Chukwumerije, MD
Kaiser Permanente Medical Center, Panorama, CA

Address: Amir K. Jaffer, MD, Department of General Internal Medicine, A72, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail: [email protected]

Dr. Jaffer has indicated that he has received grant or research support from Astra Zeneca, serves as a consultant for Aventis and Astra Zeneca, and is on the speakers’ bureau of Aventis.

This paper discusses therapies that are experimental or are not approved by the US Food and Drug Administration for the use under discussion.

Joseph H. Korn, MD
Director, Arthritis Center, Boston University School of Medicine; Chief, Rheumatology Section, Boston Medical Center

Address: Joseph H. Korn, MD, Chief, Rheumatology Section, Boston University Medical Center, 80 East Concord Street, Boston, MA 02118

The author has indicated that he has received grant or research support from the Actelion, Biogen, and Genzyme corporations and from the National Institutes of Health; serves as a consultant for the Actelion and Genzyme corporations; and is on the speaker’s bureau of the Actelion corporation.

This paper discusses therapies that are experimental or are not approved by the US Food and Drug Administration for the use under discussion.

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

Joseph H. Korn, MD
Director, Arthritis Center, Boston University School of Medicine; Chief, Rheumatology Section, Boston Medical Center

Address: Joseph H. Korn, MD, Chief, Rheumatology Section, Boston University Medical Center, 80 East Concord Street, Boston, MA 02118

The author has indicated that he has received grant or research support from the Actelion, Biogen, and Genzyme corporations and from the National Institutes of Health; serves as a consultant for the Actelion and Genzyme corporations; and is on the speaker’s bureau of the Actelion corporation.

This paper discusses therapies that are experimental or are not approved by the US Food and Drug Administration for the use under discussion.

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

Joseph H. Korn, MD
Director, Arthritis Center, Boston University School of Medicine; Chief, Rheumatology Section, Boston Medical Center

Address: Joseph H. Korn, MD, Chief, Rheumatology Section, Boston University Medical Center, 80 East Concord Street, Boston, MA 02118

The author has indicated that he has received grant or research support from the Actelion, Biogen, and Genzyme corporations and from the National Institutes of Health; serves as a consultant for the Actelion and Genzyme corporations; and is on the speaker’s bureau of the Actelion corporation.

This paper discusses therapies that are experimental or are not approved by the US Food and Drug Administration for the use under discussion.

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

Samar El-Sayegh, MD
Department of Psychiatry and Psychology, The Cleveland Clinic

Scott Bea, PsyD
Department of Psychiatry and Psychology, The Cleveland Clinic

Angela Agelopoulos
Department of Psychiatry and Psychology, The Cleveland Clinic

Address: Scott Bea, PsyD, Department of Psychiatry and Psychology, P57, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195

Samar El-Sayegh, MD
Department of Psychiatry and Psychology, The Cleveland Clinic

Scott Bea, PsyD
Department of Psychiatry and Psychology, The Cleveland Clinic

Angela Agelopoulos
Department of Psychiatry and Psychology, The Cleveland Clinic

Address: Scott Bea, PsyD, Department of Psychiatry and Psychology, P57, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195

Samar El-Sayegh, MD
Department of Psychiatry and Psychology, The Cleveland Clinic

Scott Bea, PsyD
Department of Psychiatry and Psychology, The Cleveland Clinic

Angela Agelopoulos
Department of Psychiatry and Psychology, The Cleveland Clinic

Address: Scott Bea, PsyD, Department of Psychiatry and Psychology, P57, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195

Sherif B. Mossad, MD
Department of Infectious Diseases, The Cleveland Clinic

Address: Sherif B. Mossad, MD, Department of Infectious Diseases, S32, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; E-mail [email protected]

Sherif B. Mossad, MD
Department of Infectious Diseases, The Cleveland Clinic

Address: Sherif B. Mossad, MD, Department of Infectious Diseases, S32, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; E-mail [email protected]

Sherif B. Mossad, MD
Department of Infectious Diseases, The Cleveland Clinic

Address: Sherif B. Mossad, MD, Department of Infectious Diseases, S32, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; E-mail [email protected]

Louis B. Rice, MD
Louis Stokes Cleveland VA Medical Center and Case Western Reserve University School of Medicine, Cleveland, OH

Address: Louis B. Rice, MD, Medical Service 111(W), Louis Stokes Cleveland VA Medical Center, 10701 East Boulevard, Cleveland, OH 44106, E-mail: [email protected]

The author has indicated that he has received grant or research support from the Wyeth-Ayerst, Ortho-McNeil, and Elan companies, serves as a consultant for the Wyeth-Ayerst, Ortho-McNeil, Elan, and Merck companies, and is on the speakers’ bureaus of the Wyeth-Ayerst, Merck, and Elan companies.

Louis B. Rice, MD
Louis Stokes Cleveland VA Medical Center and Case Western Reserve University School of Medicine, Cleveland, OH

Address: Louis B. Rice, MD, Medical Service 111(W), Louis Stokes Cleveland VA Medical Center, 10701 East Boulevard, Cleveland, OH 44106, E-mail: [email protected]

The author has indicated that he has received grant or research support from the Wyeth-Ayerst, Ortho-McNeil, and Elan companies, serves as a consultant for the Wyeth-Ayerst, Ortho-McNeil, Elan, and Merck companies, and is on the speakers’ bureaus of the Wyeth-Ayerst, Merck, and Elan companies.

Louis B. Rice, MD
Louis Stokes Cleveland VA Medical Center and Case Western Reserve University School of Medicine, Cleveland, OH

Address: Louis B. Rice, MD, Medical Service 111(W), Louis Stokes Cleveland VA Medical Center, 10701 East Boulevard, Cleveland, OH 44106, E-mail: [email protected]

The author has indicated that he has received grant or research support from the Wyeth-Ayerst, Ortho-McNeil, and Elan companies, serves as a consultant for the Wyeth-Ayerst, Ortho-McNeil, Elan, and Merck companies, and is on the speakers’ bureaus of the Wyeth-Ayerst, Merck, and Elan companies.

Barbara J. Messinger-Rapport, MD, PhD
Section of Geriatric Medicine, Department of General Internal Medicine, The Cleveland Clinic

Address: Barbara J. Messinger-Rapport, MD, PhD, Section of Geriatric Medicine, Department of Internal Medicine, A91, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195

The author has indicated that she is on the speaker’s bureau of the Pfizer corporation.

This paper discusses treatments that are experimental or that are not approved by the US Food and Drug Administration for the use under discussion.

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

Barbara J. Messinger-Rapport, MD, PhD
Section of Geriatric Medicine, Department of General Internal Medicine, The Cleveland Clinic

Address: Barbara J. Messinger-Rapport, MD, PhD, Section of Geriatric Medicine, Department of Internal Medicine, A91, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195

The author has indicated that she is on the speaker’s bureau of the Pfizer corporation.

This paper discusses treatments that are experimental or that are not approved by the US Food and Drug Administration for the use under discussion.

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

Barbara J. Messinger-Rapport, MD, PhD
Section of Geriatric Medicine, Department of General Internal Medicine, The Cleveland Clinic

Address: Barbara J. Messinger-Rapport, MD, PhD, Section of Geriatric Medicine, Department of Internal Medicine, A91, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195

The author has indicated that she is on the speaker’s bureau of the Pfizer corporation.

This paper discusses treatments that are experimental or that are not approved by the US Food and Drug Administration for the use under discussion.

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

Donald G. Vidt, MD
Consultant, Department of Nephrology/Hypertension, The Cleveland Clinic; Professor of Internal Medicine, The Ohio State University; reviewer, seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure

Raymond A. Borazanian, BS
Managing Editor, Cleveland Clinic Journal of Medicine

Address: Donald G. Vidt, MD, Department of Nephrology/Hypertension, A51, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail: [email protected]

Donald G. Vidt, MD
Consultant, Department of Nephrology/Hypertension, The Cleveland Clinic; Professor of Internal Medicine, The Ohio State University; reviewer, seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure

Raymond A. Borazanian, BS
Managing Editor, Cleveland Clinic Journal of Medicine

Address: Donald G. Vidt, MD, Department of Nephrology/Hypertension, A51, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail: [email protected]

Donald G. Vidt, MD
Consultant, Department of Nephrology/Hypertension, The Cleveland Clinic; Professor of Internal Medicine, The Ohio State University; reviewer, seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure

Raymond A. Borazanian, BS
Managing Editor, Cleveland Clinic Journal of Medicine

Address: Donald G. Vidt, MD, Department of Nephrology/Hypertension, A51, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail: [email protected]

Fabiane Mulinari-Brenner, MD
International Scholar, Departments of Dermatology and Pathology, The Cleveland Clinic

Wilma F. Bergfeld, MD
Head, Clinical Research, Department of Dermatology, The Cleveland Clinic

Address: Wilma F. Bergfeld, MD, Department of Dermatology, A61, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail: [email protected]

Fabiane Mulinari-Brenner, MD
International Scholar, Departments of Dermatology and Pathology, The Cleveland Clinic

Wilma F. Bergfeld, MD
Head, Clinical Research, Department of Dermatology, The Cleveland Clinic

Address: Wilma F. Bergfeld, MD, Department of Dermatology, A61, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail: [email protected]

Fabiane Mulinari-Brenner, MD
International Scholar, Departments of Dermatology and Pathology, The Cleveland Clinic

Wilma F. Bergfeld, MD
Head, Clinical Research, Department of Dermatology, The Cleveland Clinic

Address: Wilma F. Bergfeld, MD, Department of Dermatology, A61, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail: [email protected]