Drug Therapy

Sherif Mossad, MD
Department of Infectious Diseases, The Cleveland Clinic

Address: Sherif B. Mossad, MD, Department of Infectious Disease, S32, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; email [email protected]

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

Sherif Mossad, MD
Department of Infectious Diseases, The Cleveland Clinic

Address: Sherif B. Mossad, MD, Department of Infectious Disease, S32, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; email [email protected]

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

Sherif Mossad, MD
Department of Infectious Diseases, The Cleveland Clinic

Address: Sherif B. Mossad, MD, Department of Infectious Disease, S32, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; email [email protected]

Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.

Mark W. Russo, MD
Center for the Study of Hepatitis C, Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, NY

Ira M. Jacobson, MD
Center for the Study of Hepatitis C, Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, NY

Address: Mark W. Russo, MD, University of North Carolina, Division of Digestive Diseases, CB#7080, Bioinformatics Building, Room 1104, Mason Farm Road, Chapel Hill, NC 27599-7080; e-mail [email protected]

Mark W. Russo, MD
Center for the Study of Hepatitis C, Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, NY

Ira M. Jacobson, MD
Center for the Study of Hepatitis C, Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, NY

Address: Mark W. Russo, MD, University of North Carolina, Division of Digestive Diseases, CB#7080, Bioinformatics Building, Room 1104, Mason Farm Road, Chapel Hill, NC 27599-7080; e-mail [email protected]

Mark W. Russo, MD
Center for the Study of Hepatitis C, Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, NY

Ira M. Jacobson, MD
Center for the Study of Hepatitis C, Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, NY

Address: Mark W. Russo, MD, University of North Carolina, Division of Digestive Diseases, CB#7080, Bioinformatics Building, Room 1104, Mason Farm Road, Chapel Hill, NC 27599-7080; e-mail [email protected]

Ahmed Abdel Latif, MD
Department of General Internal Medicine, The Cleveland Clinic

Barbara J. Messinger-Rapport, MD, PhD
Section of Geriatric Medicine, Department of General Internal Medicine, The Cleveland Clinic

Address: Barbara J. Messinger-Rapport, MD, PhD, Department of General Internal Medicine, A91, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected]

Ahmed Abdel Latif, MD
Department of General Internal Medicine, The Cleveland Clinic

Barbara J. Messinger-Rapport, MD, PhD
Section of Geriatric Medicine, Department of General Internal Medicine, The Cleveland Clinic

Address: Barbara J. Messinger-Rapport, MD, PhD, Department of General Internal Medicine, A91, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected]

Ahmed Abdel Latif, MD
Department of General Internal Medicine, The Cleveland Clinic

Barbara J. Messinger-Rapport, MD, PhD
Section of Geriatric Medicine, Department of General Internal Medicine, The Cleveland Clinic

Address: Barbara J. Messinger-Rapport, MD, PhD, Department of General Internal Medicine, A91, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected]

Keith Ellis, MD
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation

Sorin Brener, MD
Director, Angiography Core Laboratory, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation

Address: Sorin Brener, MD, Department of Cardiovascular Medicine, F25, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected]

Keith Ellis, MD
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation

Sorin Brener, MD
Director, Angiography Core Laboratory, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation

Address: Sorin Brener, MD, Department of Cardiovascular Medicine, F25, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected]

Keith Ellis, MD
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation

Sorin Brener, MD
Director, Angiography Core Laboratory, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation

Address: Sorin Brener, MD, Department of Cardiovascular Medicine, F25, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected]

John D. Clough, MD
Editor in Chief

John D. Clough, MD
Editor in Chief

John D. Clough, MD
Editor in Chief

Michael S. Lauer, MD
Director of Clinical Research, Department of Cardiovascular Medicine, The Cleveland Clinic; Contributing Editor, JAMA

Address: Michael S. Lauer, MD, Department of Cardiovascular Medicine, F25, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail: [email protected]

Michael S. Lauer, MD
Director of Clinical Research, Department of Cardiovascular Medicine, The Cleveland Clinic; Contributing Editor, JAMA

Address: Michael S. Lauer, MD, Department of Cardiovascular Medicine, F25, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail: [email protected]

Michael S. Lauer, MD
Director of Clinical Research, Department of Cardiovascular Medicine, The Cleveland Clinic; Contributing Editor, JAMA

Address: Michael S. Lauer, MD, Department of Cardiovascular Medicine, F25, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail: [email protected]

Mario E. Lacouture, MD
Section of Dermatology, University of Chicago Hospitals

Fred H. Hsieh, MD
Section of Allergy and Immunology, Department of Pulmonary and Critical Care Medicine, The Cleveland Clinic

Address: Fred H. Hsieh, MD, Section of Allergy and Immunology, Department of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, A72, 9500 Euclid Avenue, Cleveland, OH 44195

Mario E. Lacouture, MD
Section of Dermatology, University of Chicago Hospitals

Fred H. Hsieh, MD
Section of Allergy and Immunology, Department of Pulmonary and Critical Care Medicine, The Cleveland Clinic

Address: Fred H. Hsieh, MD, Section of Allergy and Immunology, Department of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, A72, 9500 Euclid Avenue, Cleveland, OH 44195

Mario E. Lacouture, MD
Section of Dermatology, University of Chicago Hospitals

Fred H. Hsieh, MD
Section of Allergy and Immunology, Department of Pulmonary and Critical Care Medicine, The Cleveland Clinic

Address: Fred H. Hsieh, MD, Section of Allergy and Immunology, Department of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation, A72, 9500 Euclid Avenue, Cleveland, OH 44195

Hitinder S. Gurm, MBBS
Department of Cardiovascular Medicine, The Cleveland Clinic

Byron Hoogwerf, MD
Department of Endocrinology and Metabolism; Section of Preventive Cardiology, Department of Cardiovascular Medicine, Director; Internal Medicine Residency Program, The Cleveland Clinic

Address: Hitinder S. Gurm, MBBS, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195

Dr. Hoogwerf has indicated that he is a consultant for Astra Zeneca and Merck, and is on the speakers’ bureau for Merck and Schering Plough.

Hitinder S. Gurm, MBBS
Department of Cardiovascular Medicine, The Cleveland Clinic

Byron Hoogwerf, MD
Department of Endocrinology and Metabolism; Section of Preventive Cardiology, Department of Cardiovascular Medicine, Director; Internal Medicine Residency Program, The Cleveland Clinic

Address: Hitinder S. Gurm, MBBS, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195

Dr. Hoogwerf has indicated that he is a consultant for Astra Zeneca and Merck, and is on the speakers’ bureau for Merck and Schering Plough.

Hitinder S. Gurm, MBBS
Department of Cardiovascular Medicine, The Cleveland Clinic

Byron Hoogwerf, MD
Department of Endocrinology and Metabolism; Section of Preventive Cardiology, Department of Cardiovascular Medicine, Director; Internal Medicine Residency Program, The Cleveland Clinic

Address: Hitinder S. Gurm, MBBS, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195

Dr. Hoogwerf has indicated that he is a consultant for Astra Zeneca and Merck, and is on the speakers’ bureau for Merck and Schering Plough.

Rashmi Deshmukh, MD
Department of Psychiatry, The Cleveland Clinic

Kathleen Franco, MD
Department of Psychiatry, The Cleveland Clinic

Address: Kathleen Franco, MD, Department of Psychiatry, P57, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195

This paper discusses therapies that are experimental or are not approved by the US Food and Drug Administration for the use under discussion.

Rashmi Deshmukh, MD
Department of Psychiatry, The Cleveland Clinic

Kathleen Franco, MD
Department of Psychiatry, The Cleveland Clinic

Address: Kathleen Franco, MD, Department of Psychiatry, P57, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195

This paper discusses therapies that are experimental or are not approved by the US Food and Drug Administration for the use under discussion.

Rashmi Deshmukh, MD
Department of Psychiatry, The Cleveland Clinic

Kathleen Franco, MD
Department of Psychiatry, The Cleveland Clinic

Address: Kathleen Franco, MD, Department of Psychiatry, P57, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195

This paper discusses therapies that are experimental or are not approved by the US Food and Drug Administration for the use under discussion.

Amir K. Jaffer, MD
Medical Director, The Internal Medicine Preoperative Assessment Consultation and Treatment (IMPACT) Center and the Anticoagulation Clinic, Section of Hospital and Preoperative Medicine, Department of General Internal Medicine, The Cleveland Clinic

Daniel J. Brotman, MD
Section of Hospital and Preoperative Medicine, Department of General Internal Medicine, The Cleveland Clinic

Nkem Chukwumerije, MD
Kaiser Permanente Medical Center, Panorama, CA

Address: Amir K. Jaffer, MD, Department of General Internal Medicine, A72, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail: [email protected]

Dr. Jaffer has indicated that he has received grant or research support from Astra Zeneca, serves as a consultant for Aventis and Astra Zeneca, and is on the speakers’ bureau of Aventis.

This paper discusses therapies that are experimental or are not approved by the US Food and Drug Administration for the use under discussion.

Amir K. Jaffer, MD
Medical Director, The Internal Medicine Preoperative Assessment Consultation and Treatment (IMPACT) Center and the Anticoagulation Clinic, Section of Hospital and Preoperative Medicine, Department of General Internal Medicine, The Cleveland Clinic

Daniel J. Brotman, MD
Section of Hospital and Preoperative Medicine, Department of General Internal Medicine, The Cleveland Clinic

Nkem Chukwumerije, MD
Kaiser Permanente Medical Center, Panorama, CA

Address: Amir K. Jaffer, MD, Department of General Internal Medicine, A72, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail: [email protected]

Dr. Jaffer has indicated that he has received grant or research support from Astra Zeneca, serves as a consultant for Aventis and Astra Zeneca, and is on the speakers’ bureau of Aventis.

This paper discusses therapies that are experimental or are not approved by the US Food and Drug Administration for the use under discussion.

Amir K. Jaffer, MD
Medical Director, The Internal Medicine Preoperative Assessment Consultation and Treatment (IMPACT) Center and the Anticoagulation Clinic, Section of Hospital and Preoperative Medicine, Department of General Internal Medicine, The Cleveland Clinic

Daniel J. Brotman, MD
Section of Hospital and Preoperative Medicine, Department of General Internal Medicine, The Cleveland Clinic

Nkem Chukwumerije, MD
Kaiser Permanente Medical Center, Panorama, CA

Address: Amir K. Jaffer, MD, Department of General Internal Medicine, A72, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail: [email protected]

Dr. Jaffer has indicated that he has received grant or research support from Astra Zeneca, serves as a consultant for Aventis and Astra Zeneca, and is on the speakers’ bureau of Aventis.

This paper discusses therapies that are experimental or are not approved by the US Food and Drug Administration for the use under discussion.