Ajay Kumar, MD
Section of Hospital Medicine, Department of General Internal Medicine, Cleveland Clinic, Cleveland, OH

Vesselin Dimov, MD
Section of Hospital Medicine, Department of General Internal Medicine, Cleveland Clinic, Cleveland, OH

Correspondence: Ajay Kumar, MD, Section of Hospital Medicine, Department of General Internal Medicine, Cleveland Clinic, 9500 Euclid Avenue, A13, Cleveland, OH 44195; [email protected]

Both authors reported that they have no commercial affiliations or financial interests that pose a potential conflict of interest with this article.

Ajay Kumar, MD
Section of Hospital Medicine, Department of General Internal Medicine, Cleveland Clinic, Cleveland, OH

Vesselin Dimov, MD
Section of Hospital Medicine, Department of General Internal Medicine, Cleveland Clinic, Cleveland, OH

Correspondence: Ajay Kumar, MD, Section of Hospital Medicine, Department of General Internal Medicine, Cleveland Clinic, 9500 Euclid Avenue, A13, Cleveland, OH 44195; [email protected]

Both authors reported that they have no commercial affiliations or financial interests that pose a potential conflict of interest with this article.

Ajay Kumar, MD
Section of Hospital Medicine, Department of General Internal Medicine, Cleveland Clinic, Cleveland, OH

Vesselin Dimov, MD
Section of Hospital Medicine, Department of General Internal Medicine, Cleveland Clinic, Cleveland, OH

Correspondence: Ajay Kumar, MD, Section of Hospital Medicine, Department of General Internal Medicine, Cleveland Clinic, 9500 Euclid Avenue, A13, Cleveland, OH 44195; [email protected]

Both authors reported that they have no commercial affiliations or financial interests that pose a potential conflict of interest with this article.

Julie E. Burning, ScD
Professor of Medicine, Harvard Medical School; Division of Preventive Medicine, Brigham and Women’s Hospital, Boston; principal investigator, Women’s Health Study

Address: Julie E. Buring, ScD, Division of Preventive Medicine, Brigham and Women’s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215; e-mail [email protected]

Dr. Buring has received investigator-initiated research funding and support as Principal Investigator from the National Institutes of Health (the National Heart, Lung, and Blood Institute, the National Cancer Institute, and the National Institute of Aging) and Dow Corning Corporation; has received research support for pills and/or packaging from Bayer Health Care and the Natural Source Vitamin E Association; has received honoraria from Bayer for speaking engagements; and has served on a study’s external scientific advisory committee for Procter & Gamble.

This Medical Grand Rounds article is based on edited transcripts from a Heart Center Grand Rounds presentation at Cleveland Clinic. It was approved by the author but was not peer-reviewed.

Julie E. Burning, ScD
Professor of Medicine, Harvard Medical School; Division of Preventive Medicine, Brigham and Women’s Hospital, Boston; principal investigator, Women’s Health Study

Address: Julie E. Buring, ScD, Division of Preventive Medicine, Brigham and Women’s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215; e-mail [email protected]

Dr. Buring has received investigator-initiated research funding and support as Principal Investigator from the National Institutes of Health (the National Heart, Lung, and Blood Institute, the National Cancer Institute, and the National Institute of Aging) and Dow Corning Corporation; has received research support for pills and/or packaging from Bayer Health Care and the Natural Source Vitamin E Association; has received honoraria from Bayer for speaking engagements; and has served on a study’s external scientific advisory committee for Procter & Gamble.

This Medical Grand Rounds article is based on edited transcripts from a Heart Center Grand Rounds presentation at Cleveland Clinic. It was approved by the author but was not peer-reviewed.

Julie E. Burning, ScD
Professor of Medicine, Harvard Medical School; Division of Preventive Medicine, Brigham and Women’s Hospital, Boston; principal investigator, Women’s Health Study

Address: Julie E. Buring, ScD, Division of Preventive Medicine, Brigham and Women’s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215; e-mail [email protected]

Dr. Buring has received investigator-initiated research funding and support as Principal Investigator from the National Institutes of Health (the National Heart, Lung, and Blood Institute, the National Cancer Institute, and the National Institute of Aging) and Dow Corning Corporation; has received research support for pills and/or packaging from Bayer Health Care and the Natural Source Vitamin E Association; has received honoraria from Bayer for speaking engagements; and has served on a study’s external scientific advisory committee for Procter & Gamble.

This Medical Grand Rounds article is based on edited transcripts from a Heart Center Grand Rounds presentation at Cleveland Clinic. It was approved by the author but was not peer-reviewed.

Tina Bolek, MD
Department of Diagnostic Radiology, Cleveland Clinic

Mark E. Baker, MD
Department of Diagnostic Radiology, Cleveland Clinic

R. Matthew Walsh, MD
Department of General Surgery, Cleveland Clinic

Address: Mark E. Baker, Department of Diagnostic Radiology, Hb6, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195; [email protected]

Tina Bolek, MD
Department of Diagnostic Radiology, Cleveland Clinic

Mark E. Baker, MD
Department of Diagnostic Radiology, Cleveland Clinic

R. Matthew Walsh, MD
Department of General Surgery, Cleveland Clinic

Address: Mark E. Baker, Department of Diagnostic Radiology, Hb6, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195; [email protected]

Tina Bolek, MD
Department of Diagnostic Radiology, Cleveland Clinic

Mark E. Baker, MD
Department of Diagnostic Radiology, Cleveland Clinic

R. Matthew Walsh, MD
Department of General Surgery, Cleveland Clinic

Address: Mark E. Baker, Department of Diagnostic Radiology, Hb6, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195; [email protected]

Thomas G. Fraser, MD
Department of Infectious Diseases, Cleveland Clinic

Christine Hansen, PharmD
Department of Pharmacy, Shands Hospital, Orlando, FL

Jennifer K. Long, PharmD
Department of Pharmacy, Cleveland Clinic

Address: Thomas G. Fraser, MD, Department of Infectious Disease, S32, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected]

Dr. Fraser is a member of the Wyeth Emerging Pathogens speakers’ bureau.

Dr. Long is a member of the Cubist speakers’ bureau and the Pfizer speakers’ bureau. This manuscript was generated without outside funding.

Thomas G. Fraser, MD
Department of Infectious Diseases, Cleveland Clinic

Christine Hansen, PharmD
Department of Pharmacy, Shands Hospital, Orlando, FL

Jennifer K. Long, PharmD
Department of Pharmacy, Cleveland Clinic

Address: Thomas G. Fraser, MD, Department of Infectious Disease, S32, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected]

Dr. Fraser is a member of the Wyeth Emerging Pathogens speakers’ bureau.

Dr. Long is a member of the Cubist speakers’ bureau and the Pfizer speakers’ bureau. This manuscript was generated without outside funding.

Thomas G. Fraser, MD
Department of Infectious Diseases, Cleveland Clinic

Christine Hansen, PharmD
Department of Pharmacy, Shands Hospital, Orlando, FL

Jennifer K. Long, PharmD
Department of Pharmacy, Cleveland Clinic

Address: Thomas G. Fraser, MD, Department of Infectious Disease, S32, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected]

Dr. Fraser is a member of the Wyeth Emerging Pathogens speakers’ bureau.

Dr. Long is a member of the Cubist speakers’ bureau and the Pfizer speakers’ bureau. This manuscript was generated without outside funding.

Michele M. Hooper, MD, MS
Associate director of medical affairs, Amgen Inc, Thousand Oaks, CA

Address: Michele M. Hooper, MD, Amgen, One Amgen Center Drive, MS 27-1-D, Thousand Oaks, CA 91320; e-mail [email protected]

Michele M. Hooper, MD, MS
Associate director of medical affairs, Amgen Inc, Thousand Oaks, CA

Address: Michele M. Hooper, MD, Amgen, One Amgen Center Drive, MS 27-1-D, Thousand Oaks, CA 91320; e-mail [email protected]

Michele M. Hooper, MD, MS
Associate director of medical affairs, Amgen Inc, Thousand Oaks, CA

Address: Michele M. Hooper, MD, Amgen, One Amgen Center Drive, MS 27-1-D, Thousand Oaks, CA 91320; e-mail [email protected]

Mohammad Hassan Pervaiz, MD
Department of Medicine, Michigan State University, East Lansing

Michael G. Dickinson, MD
Department of Cardiovascular Medicine, Cleveland Clinic

Mohamad Yamani, MD
Department of Cardiovascular Medicine, Cleveland Clinic

Address: Mohammad Hassan Pervaiz, MD, B-301 Clinical Center, Michigan State University, East Lansing, MI 44824; email [email protected]

Mohammad Hassan Pervaiz, MD
Department of Medicine, Michigan State University, East Lansing

Michael G. Dickinson, MD
Department of Cardiovascular Medicine, Cleveland Clinic

Mohamad Yamani, MD
Department of Cardiovascular Medicine, Cleveland Clinic

Address: Mohammad Hassan Pervaiz, MD, B-301 Clinical Center, Michigan State University, East Lansing, MI 44824; email [email protected]

Mohammad Hassan Pervaiz, MD
Department of Medicine, Michigan State University, East Lansing

Michael G. Dickinson, MD
Department of Cardiovascular Medicine, Cleveland Clinic

Mohamad Yamani, MD
Department of Cardiovascular Medicine, Cleveland Clinic

Address: Mohammad Hassan Pervaiz, MD, B-301 Clinical Center, Michigan State University, East Lansing, MI 44824; email [email protected]

Jadwiga Loj, MD
Department of Medicine, Advocate Lutheran General Hospital, Park Ridge, IL

Glen D. Solomon, MD
Department of Medicine, Advocate Lutheran General Hospital, Park Ridge, IL

Address: Glen D. Solomon, MD, Department of Medicine, Advocate Lutheran General Hospital, 1775 Dempster Street, Park Ridge, IL 60068; e-mail [email protected]

Jadwiga Loj, MD
Department of Medicine, Advocate Lutheran General Hospital, Park Ridge, IL

Glen D. Solomon, MD
Department of Medicine, Advocate Lutheran General Hospital, Park Ridge, IL

Address: Glen D. Solomon, MD, Department of Medicine, Advocate Lutheran General Hospital, 1775 Dempster Street, Park Ridge, IL 60068; e-mail [email protected]

Jadwiga Loj, MD
Department of Medicine, Advocate Lutheran General Hospital, Park Ridge, IL

Glen D. Solomon, MD
Department of Medicine, Advocate Lutheran General Hospital, Park Ridge, IL

Address: Glen D. Solomon, MD, Department of Medicine, Advocate Lutheran General Hospital, 1775 Dempster Street, Park Ridge, IL 60068; e-mail [email protected]

Paul J. Grant, MD
Clinical instructor, Division of General Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI

Amir K. Jaffer, MD
Medical director, IMPACT (Internal Medicine Preoperative Assessment Consultation and Treatment) Center; medical director, Anticoagulation Clinic, Section of Hospital Medicine, Cleveland Clinic

Address: Amir K. Jaffer, MD, IMPACT Center, A13, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected]

Dr. Jaffer has indicated that he is on the speakers’ bureau of Sanofi-Aventis corporation, is a consultant for Sanofi-Aventis and AstraZeneca, and has received honoraria from Sanofi-Aventis.

Paul J. Grant, MD
Clinical instructor, Division of General Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI

Amir K. Jaffer, MD
Medical director, IMPACT (Internal Medicine Preoperative Assessment Consultation and Treatment) Center; medical director, Anticoagulation Clinic, Section of Hospital Medicine, Cleveland Clinic

Address: Amir K. Jaffer, MD, IMPACT Center, A13, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected]

Dr. Jaffer has indicated that he is on the speakers’ bureau of Sanofi-Aventis corporation, is a consultant for Sanofi-Aventis and AstraZeneca, and has received honoraria from Sanofi-Aventis.

Paul J. Grant, MD
Clinical instructor, Division of General Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI

Amir K. Jaffer, MD
Medical director, IMPACT (Internal Medicine Preoperative Assessment Consultation and Treatment) Center; medical director, Anticoagulation Clinic, Section of Hospital Medicine, Cleveland Clinic

Address: Amir K. Jaffer, MD, IMPACT Center, A13, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected]

Dr. Jaffer has indicated that he is on the speakers’ bureau of Sanofi-Aventis corporation, is a consultant for Sanofi-Aventis and AstraZeneca, and has received honoraria from Sanofi-Aventis.