The deadline to submit applications for the SVS Foundation Research Career Development Travel Award is Aug. 15. This award aims to develop strong leaders in vascular surgery. Awardees are assigned an SVS research mentor and are provided with funds to attend an establish research career development course.

The deadline to submit applications for the SVS Foundation Research Career Development Travel Award is Aug. 15. This award aims to develop strong leaders in vascular surgery. Awardees are assigned an SVS research mentor and are provided with funds to attend an establish research career development course.

The deadline to submit applications for the SVS Foundation Research Career Development Travel Award is Aug. 15. This award aims to develop strong leaders in vascular surgery. Awardees are assigned an SVS research mentor and are provided with funds to attend an establish research career development course.

The deadline for applications for the SVS International Scholars Program has been extended to Sept. 1. The program provides up to four scholarships to qualified young vascular surgeons from countries other than the United States or Canada. Awardees receive $5,000 each, to attend the 2019 Vascular Annual Meeting and to visit clinical, teaching and research facilities in the U.S. and Canada. Apply today.

The deadline for applications for the SVS International Scholars Program has been extended to Sept. 1. The program provides up to four scholarships to qualified young vascular surgeons from countries other than the United States or Canada. Awardees receive $5,000 each, to attend the 2019 Vascular Annual Meeting and to visit clinical, teaching and research facilities in the U.S. and Canada. Apply today.

The deadline for applications for the SVS International Scholars Program has been extended to Sept. 1. The program provides up to four scholarships to qualified young vascular surgeons from countries other than the United States or Canada. Awardees receive $5,000 each, to attend the 2019 Vascular Annual Meeting and to visit clinical, teaching and research facilities in the U.S. and Canada. Apply today.

PCOS Update 2018
R. Mimi Secor, DNP, FNP-BC, FAANP, Nurse Practitioner Associates for Continuing Education

Polycystic ovary syndrome is the most common reproductive endocrine disorder, affecting 1 in 15 women in the United States. Secor reviewed the signs, symptoms, risk factors, and pathophysiology of the condition, as well as new research pointing toward its relationship with the gut microbiome. She also covered the work-up, differential, and considerations if pregnancy is desired. The treatment discussion included off-label use of metformin and letrozole.

Hypercalcemia/Parathyroid Disease Unraveled: 3 Cases to Consider
Ji Hyun (CJ) Chun, PA-C, MPAS, BC-ADM, American Society of Endocrine PAs

Chun reviewed the physiology of calcium homeostasis and presented a work-up plan for hypercalcemia and hyperparathyroidism. He shared the surgical criteria for parathyroidectomy, as well as nonsurgical treatment options, and discussed the development, potential consequences, and treatment of vitamin D deficiency.

Osteoporosis: Sticks and Stones May or May Not Break My Bones?
Richard S. Pope, MPAS, PA-C, DFAAPA, CPAAPA, Quinnipiac University

FRAX^® (fracture risk assessment tool), bone mineral density (BMD), vertebral fracture assessment, and trabecular bone score are all validated tools for evaluating osteoporosis, began Pope. Age and previous fractures are perhaps the strongest, independent predictors of fracture risk. Antiresorptive therapy produces a modest increase in BMD. Anabolic therapy with parathyroid hormone increases BMD more than antiresorptive treatment, but it is not yet obvious that fracture protection is greater.

Osteoporosis: Case Studies for Consideration
R. Mimi Secor, DNP, FNP-BC, FAANP, Nurse Practitioner Associates for Continuing Education, and Richard S. Pope, MPAS, PA-C, DFAAPA, CPAAPA, Quinnipiac University

How long should you treat patients with bisphosphonates? How is osteoporosis treatment best monitored? What is the best definition of successful treatment of osteoporosis? Secor and Pope answered these questions and emphasized reviewing with patients diet and lifestyle modifications and their importance to bone health. They also explained how to analyze risk factors beyond the DXA (dual-energy x-ray absorptiometry) score (eg, height loss), and how to target therapy based on co‐morbidities.

Continue to: Men's and Women's Health Issues and Endocrine Disease

Men’s and Women’s Health Issues and Endocrine Disease
Ji Hyun (CJ) Chun, PA-C, MPAS, BC-ADM, American Society of Endocrine PAs, and R. Mimi Secor, DNP, FNP-BC, FAANP, Nurse Practitioner Associates for Continuing Education

Chun and Secor reviewed the physiology and pathophysiology of male hypogonadism, the elements of a comprehensive diagnostic protocol, and appropriate monitoring of patients taking testosterone replacement therapy (TRT). They said that differentiating organic hypogonadism and late-onset hypogonadism (LOH) is of utmost importance to prevent long-term complications of true hypogonadism. While the benefits of treatment clearly outweigh the risks for patients with organic hypogonadism, the benefit-risk ratio for patients with LOH is unclear.

PCOS Update 2018
R. Mimi Secor, DNP, FNP-BC, FAANP, Nurse Practitioner Associates for Continuing Education

Polycystic ovary syndrome is the most common reproductive endocrine disorder, affecting 1 in 15 women in the United States. Secor reviewed the signs, symptoms, risk factors, and pathophysiology of the condition, as well as new research pointing toward its relationship with the gut microbiome. She also covered the work-up, differential, and considerations if pregnancy is desired. The treatment discussion included off-label use of metformin and letrozole.

Hypercalcemia/Parathyroid Disease Unraveled: 3 Cases to Consider
Ji Hyun (CJ) Chun, PA-C, MPAS, BC-ADM, American Society of Endocrine PAs

Chun reviewed the physiology of calcium homeostasis and presented a work-up plan for hypercalcemia and hyperparathyroidism. He shared the surgical criteria for parathyroidectomy, as well as nonsurgical treatment options, and discussed the development, potential consequences, and treatment of vitamin D deficiency.

Osteoporosis: Sticks and Stones May or May Not Break My Bones?
Richard S. Pope, MPAS, PA-C, DFAAPA, CPAAPA, Quinnipiac University

FRAX^® (fracture risk assessment tool), bone mineral density (BMD), vertebral fracture assessment, and trabecular bone score are all validated tools for evaluating osteoporosis, began Pope. Age and previous fractures are perhaps the strongest, independent predictors of fracture risk. Antiresorptive therapy produces a modest increase in BMD. Anabolic therapy with parathyroid hormone increases BMD more than antiresorptive treatment, but it is not yet obvious that fracture protection is greater.

Osteoporosis: Case Studies for Consideration
R. Mimi Secor, DNP, FNP-BC, FAANP, Nurse Practitioner Associates for Continuing Education, and Richard S. Pope, MPAS, PA-C, DFAAPA, CPAAPA, Quinnipiac University

How long should you treat patients with bisphosphonates? How is osteoporosis treatment best monitored? What is the best definition of successful treatment of osteoporosis? Secor and Pope answered these questions and emphasized reviewing with patients diet and lifestyle modifications and their importance to bone health. They also explained how to analyze risk factors beyond the DXA (dual-energy x-ray absorptiometry) score (eg, height loss), and how to target therapy based on co‐morbidities.

Continue to: Men's and Women's Health Issues and Endocrine Disease

Men’s and Women’s Health Issues and Endocrine Disease
Ji Hyun (CJ) Chun, PA-C, MPAS, BC-ADM, American Society of Endocrine PAs, and R. Mimi Secor, DNP, FNP-BC, FAANP, Nurse Practitioner Associates for Continuing Education

Chun and Secor reviewed the physiology and pathophysiology of male hypogonadism, the elements of a comprehensive diagnostic protocol, and appropriate monitoring of patients taking testosterone replacement therapy (TRT). They said that differentiating organic hypogonadism and late-onset hypogonadism (LOH) is of utmost importance to prevent long-term complications of true hypogonadism. While the benefits of treatment clearly outweigh the risks for patients with organic hypogonadism, the benefit-risk ratio for patients with LOH is unclear.

PCOS Update 2018
R. Mimi Secor, DNP, FNP-BC, FAANP, Nurse Practitioner Associates for Continuing Education

Polycystic ovary syndrome is the most common reproductive endocrine disorder, affecting 1 in 15 women in the United States. Secor reviewed the signs, symptoms, risk factors, and pathophysiology of the condition, as well as new research pointing toward its relationship with the gut microbiome. She also covered the work-up, differential, and considerations if pregnancy is desired. The treatment discussion included off-label use of metformin and letrozole.

Hypercalcemia/Parathyroid Disease Unraveled: 3 Cases to Consider
Ji Hyun (CJ) Chun, PA-C, MPAS, BC-ADM, American Society of Endocrine PAs

Chun reviewed the physiology of calcium homeostasis and presented a work-up plan for hypercalcemia and hyperparathyroidism. He shared the surgical criteria for parathyroidectomy, as well as nonsurgical treatment options, and discussed the development, potential consequences, and treatment of vitamin D deficiency.

Osteoporosis: Sticks and Stones May or May Not Break My Bones?
Richard S. Pope, MPAS, PA-C, DFAAPA, CPAAPA, Quinnipiac University

FRAX^® (fracture risk assessment tool), bone mineral density (BMD), vertebral fracture assessment, and trabecular bone score are all validated tools for evaluating osteoporosis, began Pope. Age and previous fractures are perhaps the strongest, independent predictors of fracture risk. Antiresorptive therapy produces a modest increase in BMD. Anabolic therapy with parathyroid hormone increases BMD more than antiresorptive treatment, but it is not yet obvious that fracture protection is greater.

Osteoporosis: Case Studies for Consideration
R. Mimi Secor, DNP, FNP-BC, FAANP, Nurse Practitioner Associates for Continuing Education, and Richard S. Pope, MPAS, PA-C, DFAAPA, CPAAPA, Quinnipiac University

How long should you treat patients with bisphosphonates? How is osteoporosis treatment best monitored? What is the best definition of successful treatment of osteoporosis? Secor and Pope answered these questions and emphasized reviewing with patients diet and lifestyle modifications and their importance to bone health. They also explained how to analyze risk factors beyond the DXA (dual-energy x-ray absorptiometry) score (eg, height loss), and how to target therapy based on co‐morbidities.

Continue to: Men's and Women's Health Issues and Endocrine Disease

Men’s and Women’s Health Issues and Endocrine Disease
Ji Hyun (CJ) Chun, PA-C, MPAS, BC-ADM, American Society of Endocrine PAs, and R. Mimi Secor, DNP, FNP-BC, FAANP, Nurse Practitioner Associates for Continuing Education

Chun and Secor reviewed the physiology and pathophysiology of male hypogonadism, the elements of a comprehensive diagnostic protocol, and appropriate monitoring of patients taking testosterone replacement therapy (TRT). They said that differentiating organic hypogonadism and late-onset hypogonadism (LOH) is of utmost importance to prevent long-term complications of true hypogonadism. While the benefits of treatment clearly outweigh the risks for patients with organic hypogonadism, the benefit-risk ratio for patients with LOH is unclear.

Morning session
Managing Thyroid Disease: Preparing for Battle
Christine Kessler, MN, ANP-BC, CNS, BC-ADM, FAANP, Metabolic Medicine Associates, and Chris Sadler, MA, PA-C, CDE, DFAAPA, Janssen Pharmaceuticals, Inc.

What lab tests should I order when patients present with signs and symptoms suggestive of thyroid disease, and how should I interpret results? In answering these questions, Kessler and Sadler described the inverse relationship of T3 and T4 to thyroid stimulating hormone (TSH), why free T4 is superior to total T4, and how to proceed when FT4 and TSH seem discordant. They also discussed additional tests that may be needed based on initial screening results, and factors (eg, agents such as biotin) that can affect the accuracy of thyroid test results.

Case Studies in Hypo and Hyperthyroidism for Clinical Consideration
Christine Kessler, MN, ANP-BC, CNS, BC-ADM, FAANP, Metabolic Medicine Associates, and Chris Sadler, MA, PA-C, CDE, DFAAPA, Janssen Pharmaceuticals, Inc.

Hypothyroidism and hyperthyroidism can be difficult to diagnose, especially in the elderly. In addition to pointing out the aspects of the physical exam and lab studies that can aid in diagnosing both conditions, Kessler and Sadler presented strategies to safely initiate, titrate, and monitor therapies; addressed controversies surrounding the management of subclinical forms; and identified triggers and early symptoms of acute thyrotoxicosis (thyroid storm) and myxedema coma.

Thyroid Concerns in Pregnancy
Christine Kessler, MN, ANP-BC, CNS, BC-ADM, FAANP, Metabolic Medicine Associates

Kessler reviewed the physiologic changes of pregnancy that influence thyroid conditions and associated lab tests, the potential complications to mother and fetus of untreated thyroid disease, and strategies for managing hypo- and hyperthyroidism throughout pregnancy and lactation. She reminded that pregnant women with hypothyroidism generally require 30% to 50% more of their thyroid medications. And when treating hyperthyroidism, use the lowest dose of antithyroid drugs that keeps maternal free T4 and free T3 near the upper limit of the normal range.

Managing the “Hot” Mess of Thyroiditis
Christine Kessler, MN, ANP-BC, CNS, BC-ADM, FAANP, Metabolic Medicine Associates, and Chris Sadler, MA, PA-C, CDE, DFAAPA, Janssen Pharmaceuticals, Inc.

While thyroiditis is transient in most patients, it requires ongoing follow-up because of the increased risk of permanent hypothyroidism. Kessler and Sadler reviewed the work-up and differential for suspected acute and subacute thyroiditis and how to interpret laboratory and thyroid scan data. They also discussed postpartum thyroiditis (the signs of which are often misdiagnosed as anxiety and stress about motherhood) and silent thyroiditis, which is similar to postpartum thyroiditis but is unassociated with pregnancy.

Continue to: Expert Tips on Evaluating Thyroid Nodules

Expert Tips on Evaluating Thyroid Nodules
Chris Sadler, MA, PA-C, CDE, DFAAPA, Janssen Pharmaceuticals, Inc.

In the United States, up to 68% of randomly selected adults have thyroid nodules. While most are benign, the number of those that are cancerous is increasing. To assist with determining which are malignant, Sadler provided insight on the clinical and ultrasound findings that suggest increased malignant potential. He also detailed an appropriate work-up, noting that ultrasound-guided fine needle aspiration remains the best means for evaluation.

Lifestyle Interventions: A New Narrative for Diabetes Management and Metabolic Health
Ellen D. Mandel, DMH, MPA, MS, PA-C, RDN, CDE, Pace University

Mandel discussed diabetes self-management education and support. She highlighted what works and what doesn’t among various diets, that sugar isn’t the only target, that dieting is only half the equation and must be coupled with physical activity (which is not the same as exercise), and that patient involvement in self-management correlates with greater long-term success.

Gut Grief: The Enteroendocrine Connection in Autoimmune Diseases
Christine Kessler, MN, ANP-BC, CNS, BC-ADM, FAANP, Metabolic Medicine Associates

“We need to look to the gut as the biggest player in chronic health and autoimmune disease,” said Kessler. Kessler went on to explain how altered gut flora impacts immune, endocrine, cardiovascular, neuropsychologic, reproductive, and metabolic health. She identified 12 endocrine-disrupting chemicals associated with autoimmunity. And she reviewed the causes of microbiome dysbiosis, the bidirectional nature of the gut-microbiome-brain axis, and strategies for promoting microbiome health.

Mind and Body: The Vicious Cycle of Depression in Diabetes and Chronic Illness
Ellen D. Mandel, DMH, MPA, MS, PA-C, RDN, CDE, Pace University

One in 4 American adults experiences mental illness in a year, and having a serious mental illness increases the risk of having a chronic medical condition. Because emotional well‐being is associated with positive diabetes outcomes, it’s imperative that diabetes self‐management education and support address psychosocial issues. It’s also important to screen for depression. To that end, Mandel shared a time-saving 2-question screening tool. 

Cold Case Studies in Renal Medication Dosing: The Good, the Bad, and the Iatrogenic
Kim Zuber, PA-C, MS, American Academy of Nephrology PAs

Using actual cases of incorrect management, Zuber pointed out the most common medications taken by patients with chronic kidney disease (CKD) by disease stage and the most common errors made with those medications. She also reviewed the over-the-counter medications that can be dangerous for patients with CKD. When prescribing for patients with CKD, Zuber reminded, go low, go slow, and rerun lab tests often.

Morning session
Managing Thyroid Disease: Preparing for Battle
Christine Kessler, MN, ANP-BC, CNS, BC-ADM, FAANP, Metabolic Medicine Associates, and Chris Sadler, MA, PA-C, CDE, DFAAPA, Janssen Pharmaceuticals, Inc.

What lab tests should I order when patients present with signs and symptoms suggestive of thyroid disease, and how should I interpret results? In answering these questions, Kessler and Sadler described the inverse relationship of T3 and T4 to thyroid stimulating hormone (TSH), why free T4 is superior to total T4, and how to proceed when FT4 and TSH seem discordant. They also discussed additional tests that may be needed based on initial screening results, and factors (eg, agents such as biotin) that can affect the accuracy of thyroid test results.

Case Studies in Hypo and Hyperthyroidism for Clinical Consideration
Christine Kessler, MN, ANP-BC, CNS, BC-ADM, FAANP, Metabolic Medicine Associates, and Chris Sadler, MA, PA-C, CDE, DFAAPA, Janssen Pharmaceuticals, Inc.

Hypothyroidism and hyperthyroidism can be difficult to diagnose, especially in the elderly. In addition to pointing out the aspects of the physical exam and lab studies that can aid in diagnosing both conditions, Kessler and Sadler presented strategies to safely initiate, titrate, and monitor therapies; addressed controversies surrounding the management of subclinical forms; and identified triggers and early symptoms of acute thyrotoxicosis (thyroid storm) and myxedema coma.

Thyroid Concerns in Pregnancy
Christine Kessler, MN, ANP-BC, CNS, BC-ADM, FAANP, Metabolic Medicine Associates

Kessler reviewed the physiologic changes of pregnancy that influence thyroid conditions and associated lab tests, the potential complications to mother and fetus of untreated thyroid disease, and strategies for managing hypo- and hyperthyroidism throughout pregnancy and lactation. She reminded that pregnant women with hypothyroidism generally require 30% to 50% more of their thyroid medications. And when treating hyperthyroidism, use the lowest dose of antithyroid drugs that keeps maternal free T4 and free T3 near the upper limit of the normal range.

Managing the “Hot” Mess of Thyroiditis
Christine Kessler, MN, ANP-BC, CNS, BC-ADM, FAANP, Metabolic Medicine Associates, and Chris Sadler, MA, PA-C, CDE, DFAAPA, Janssen Pharmaceuticals, Inc.

While thyroiditis is transient in most patients, it requires ongoing follow-up because of the increased risk of permanent hypothyroidism. Kessler and Sadler reviewed the work-up and differential for suspected acute and subacute thyroiditis and how to interpret laboratory and thyroid scan data. They also discussed postpartum thyroiditis (the signs of which are often misdiagnosed as anxiety and stress about motherhood) and silent thyroiditis, which is similar to postpartum thyroiditis but is unassociated with pregnancy.

Continue to: Expert Tips on Evaluating Thyroid Nodules

Expert Tips on Evaluating Thyroid Nodules
Chris Sadler, MA, PA-C, CDE, DFAAPA, Janssen Pharmaceuticals, Inc.

In the United States, up to 68% of randomly selected adults have thyroid nodules. While most are benign, the number of those that are cancerous is increasing. To assist with determining which are malignant, Sadler provided insight on the clinical and ultrasound findings that suggest increased malignant potential. He also detailed an appropriate work-up, noting that ultrasound-guided fine needle aspiration remains the best means for evaluation.

Lifestyle Interventions: A New Narrative for Diabetes Management and Metabolic Health
Ellen D. Mandel, DMH, MPA, MS, PA-C, RDN, CDE, Pace University

Mandel discussed diabetes self-management education and support. She highlighted what works and what doesn’t among various diets, that sugar isn’t the only target, that dieting is only half the equation and must be coupled with physical activity (which is not the same as exercise), and that patient involvement in self-management correlates with greater long-term success.

Gut Grief: The Enteroendocrine Connection in Autoimmune Diseases
Christine Kessler, MN, ANP-BC, CNS, BC-ADM, FAANP, Metabolic Medicine Associates

“We need to look to the gut as the biggest player in chronic health and autoimmune disease,” said Kessler. Kessler went on to explain how altered gut flora impacts immune, endocrine, cardiovascular, neuropsychologic, reproductive, and metabolic health. She identified 12 endocrine-disrupting chemicals associated with autoimmunity. And she reviewed the causes of microbiome dysbiosis, the bidirectional nature of the gut-microbiome-brain axis, and strategies for promoting microbiome health.

Mind and Body: The Vicious Cycle of Depression in Diabetes and Chronic Illness
Ellen D. Mandel, DMH, MPA, MS, PA-C, RDN, CDE, Pace University

One in 4 American adults experiences mental illness in a year, and having a serious mental illness increases the risk of having a chronic medical condition. Because emotional well‐being is associated with positive diabetes outcomes, it’s imperative that diabetes self‐management education and support address psychosocial issues. It’s also important to screen for depression. To that end, Mandel shared a time-saving 2-question screening tool. 

Cold Case Studies in Renal Medication Dosing: The Good, the Bad, and the Iatrogenic
Kim Zuber, PA-C, MS, American Academy of Nephrology PAs

Using actual cases of incorrect management, Zuber pointed out the most common medications taken by patients with chronic kidney disease (CKD) by disease stage and the most common errors made with those medications. She also reviewed the over-the-counter medications that can be dangerous for patients with CKD. When prescribing for patients with CKD, Zuber reminded, go low, go slow, and rerun lab tests often.

Morning session
Managing Thyroid Disease: Preparing for Battle
Christine Kessler, MN, ANP-BC, CNS, BC-ADM, FAANP, Metabolic Medicine Associates, and Chris Sadler, MA, PA-C, CDE, DFAAPA, Janssen Pharmaceuticals, Inc.

What lab tests should I order when patients present with signs and symptoms suggestive of thyroid disease, and how should I interpret results? In answering these questions, Kessler and Sadler described the inverse relationship of T3 and T4 to thyroid stimulating hormone (TSH), why free T4 is superior to total T4, and how to proceed when FT4 and TSH seem discordant. They also discussed additional tests that may be needed based on initial screening results, and factors (eg, agents such as biotin) that can affect the accuracy of thyroid test results.

Case Studies in Hypo and Hyperthyroidism for Clinical Consideration
Christine Kessler, MN, ANP-BC, CNS, BC-ADM, FAANP, Metabolic Medicine Associates, and Chris Sadler, MA, PA-C, CDE, DFAAPA, Janssen Pharmaceuticals, Inc.

Hypothyroidism and hyperthyroidism can be difficult to diagnose, especially in the elderly. In addition to pointing out the aspects of the physical exam and lab studies that can aid in diagnosing both conditions, Kessler and Sadler presented strategies to safely initiate, titrate, and monitor therapies; addressed controversies surrounding the management of subclinical forms; and identified triggers and early symptoms of acute thyrotoxicosis (thyroid storm) and myxedema coma.

Thyroid Concerns in Pregnancy
Christine Kessler, MN, ANP-BC, CNS, BC-ADM, FAANP, Metabolic Medicine Associates

Kessler reviewed the physiologic changes of pregnancy that influence thyroid conditions and associated lab tests, the potential complications to mother and fetus of untreated thyroid disease, and strategies for managing hypo- and hyperthyroidism throughout pregnancy and lactation. She reminded that pregnant women with hypothyroidism generally require 30% to 50% more of their thyroid medications. And when treating hyperthyroidism, use the lowest dose of antithyroid drugs that keeps maternal free T4 and free T3 near the upper limit of the normal range.

Managing the “Hot” Mess of Thyroiditis
Christine Kessler, MN, ANP-BC, CNS, BC-ADM, FAANP, Metabolic Medicine Associates, and Chris Sadler, MA, PA-C, CDE, DFAAPA, Janssen Pharmaceuticals, Inc.

While thyroiditis is transient in most patients, it requires ongoing follow-up because of the increased risk of permanent hypothyroidism. Kessler and Sadler reviewed the work-up and differential for suspected acute and subacute thyroiditis and how to interpret laboratory and thyroid scan data. They also discussed postpartum thyroiditis (the signs of which are often misdiagnosed as anxiety and stress about motherhood) and silent thyroiditis, which is similar to postpartum thyroiditis but is unassociated with pregnancy.

Continue to: Expert Tips on Evaluating Thyroid Nodules

Expert Tips on Evaluating Thyroid Nodules
Chris Sadler, MA, PA-C, CDE, DFAAPA, Janssen Pharmaceuticals, Inc.

In the United States, up to 68% of randomly selected adults have thyroid nodules. While most are benign, the number of those that are cancerous is increasing. To assist with determining which are malignant, Sadler provided insight on the clinical and ultrasound findings that suggest increased malignant potential. He also detailed an appropriate work-up, noting that ultrasound-guided fine needle aspiration remains the best means for evaluation.

Lifestyle Interventions: A New Narrative for Diabetes Management and Metabolic Health
Ellen D. Mandel, DMH, MPA, MS, PA-C, RDN, CDE, Pace University

Mandel discussed diabetes self-management education and support. She highlighted what works and what doesn’t among various diets, that sugar isn’t the only target, that dieting is only half the equation and must be coupled with physical activity (which is not the same as exercise), and that patient involvement in self-management correlates with greater long-term success.

Gut Grief: The Enteroendocrine Connection in Autoimmune Diseases
Christine Kessler, MN, ANP-BC, CNS, BC-ADM, FAANP, Metabolic Medicine Associates

“We need to look to the gut as the biggest player in chronic health and autoimmune disease,” said Kessler. Kessler went on to explain how altered gut flora impacts immune, endocrine, cardiovascular, neuropsychologic, reproductive, and metabolic health. She identified 12 endocrine-disrupting chemicals associated with autoimmunity. And she reviewed the causes of microbiome dysbiosis, the bidirectional nature of the gut-microbiome-brain axis, and strategies for promoting microbiome health.

Mind and Body: The Vicious Cycle of Depression in Diabetes and Chronic Illness
Ellen D. Mandel, DMH, MPA, MS, PA-C, RDN, CDE, Pace University

One in 4 American adults experiences mental illness in a year, and having a serious mental illness increases the risk of having a chronic medical condition. Because emotional well‐being is associated with positive diabetes outcomes, it’s imperative that diabetes self‐management education and support address psychosocial issues. It’s also important to screen for depression. To that end, Mandel shared a time-saving 2-question screening tool. 

Cold Case Studies in Renal Medication Dosing: The Good, the Bad, and the Iatrogenic
Kim Zuber, PA-C, MS, American Academy of Nephrology PAs

Using actual cases of incorrect management, Zuber pointed out the most common medications taken by patients with chronic kidney disease (CKD) by disease stage and the most common errors made with those medications. She also reviewed the over-the-counter medications that can be dangerous for patients with CKD. When prescribing for patients with CKD, Zuber reminded, go low, go slow, and rerun lab tests often.

Morning session

Case Studies in Type 2 Diabetes: Achieving Goals Together—A Gluco-Patient Centric Approach
Scott Urquhart, PA-C, DFAAPA, James Madison University and George Washington University, and Lucia M. Novak, MSN, ANP-BC, BC-ADM, CDTC, The Uniformed Services University of the Health Sciences

Using case studies, Urquhart and Novak first reviewed how each case would be managed according to the latest American Diabetes Association and American Association of Clinical Endocrinologists guidelines and recommendations and then explained how management might be altered by assuming a more gluco-patient centric approach. The latter, they noted, engages patients as partners in choosing medications and pays special attention to the individual’s concerns and priorities in order to empower patients and optimize outcomes. “Patients come with their own terms/non-negotiables that will ultimately determine therapeutic choices, as well as overall success.” While metformin is a safe and effective first-line therapy choice, it is often necessary and appropriate to consider other agents that address the glycemic goals of the individual patient, possess secondary (nonglycemic) benefits, and are better suited to the patient’s lifestyle, fears, and/or preferences.

Diabetes Medications: Making Co$$tly Decisions
Scott Urquhart, PA-C, DFAAPA, James Madison University and George Washington University, and Lucia M. Novak, MSN, ANP-BC, BC-ADM, CDTC, The Uniformed Services University of the Health Sciences

Urquhart and Novak discussed the financial and clinical impact of barriers that interfere with optimal pharmacologic management of type 2 diabetes mellitus (T2DM) and the importance of evaluating the nonglycemic benefits, such as cardiovascular and renal protection, of diabetes medications when making treatment adjustments. When calculating cost, it is not enough to consider the face price of a drug and the patient’s insurance coverage; the cost equation must factor in the cost (risk to the patient) of complacency and the cost of not maximizing nonglycemic benefits. Complacency, on the part of the clinician, may be caused by clinical inertia; insufficient time, resources, or training; and being overwhelmed with information or confusing guidelines. Complacency on the part of the patient may stem from disease denial, burnout, or distress, or comorbidities. Urquhart and Novak also identified resources available to assist patients with managing medication costs.

Insulin Overview: Which Type and Why?
Davida F. Kruger, MSN, APRN-BC, BC-ADM, Wayne State University and Michigan State University

In reviewing the differences between the basal, prandial, and premixed/biphasic insulin products currently available for the treatment of T2DM in the United States, Kruger emphasized the importance of understanding differences in potency between available products and being able to identify the insulin contained in vials vs pens. Also included in the discussion were differences in physiologic action, pharmacokinetics, dosing, and their pros and cons in various patient populations. Kruger concluded with a look at insulin products on the horizon.

Case Studies continued: Moving Beyond your Comfort Zone
Donna Jornsay, MS, BSN, CPNP, BC-ADM, CDE, CDTC, Mills Peninsula Medical Center, and Davida F. Kruger, MSN, APRN-BC, BC-ADM, Wayne State University and Michigan State University

Using case studies, Jornsay and Kruger reviewed how to choose from among the various insulins available, when and how to initiate and titrate insulin, and the step-wise, trial insulin strategies used for each case before arriving at a treatment approach that worked. They emphasized the importance of recognizing potential barriers to starting insulin and the support and education patients require to be successful. Roadblocks to health care providers providing timely insulin initiation may include concerns about patient adherence, hypoglycemia, pain from glucose monitoring and/or insulin injections, and patient age. Patient roadblocks may include the belief that their T2DM is not sufficiently severe or that insulin will not help.

Continue to: Afternoon session

Afternoon session
Nephrology Secrets: Diabetic Kidney Disease (DKD) and Hypertension
Kim Zuber, PA-C, MS, Executive Director of the American Academy of Nephrology PAs

Zuber focused on the diabetic kidney, noting that 30 million Americans (15% of the population) have chronic kidney disease (CKD), and that many of these don’t know they have it. She talked about the effect of DM on the kidneys, the stages of CKD, and the significance of albumin and of decreasing proteinuria. Switching gears, Zuber then discussed management of patients with diabetes and hypertension, noting that patients with DM are twice as likely to die of cardiovascular disease as those without diabetes, and that CKD occurs 4 times more frequently in patients with hypertension than in those without. While disagreement about target blood pressure goals complicates treatment, she provided tips for step-wise pharmacologic management and for whether an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker should be first-line treatment.

Numb Toes and Other Woes: Diabetic Peripheral and Autonomic Neuropathies
Lucia M. Novak, MSN, ANP-BC, BC-ADM, CDTC, The Uniformed Services University of the Health Sciences

Novak emphasized that early and aggressive glucose stabilization and control is key to minimizing the neuropathic complications affecting patients with diabetes. She discussed recognizing the clinical manifestations of these underdiagnosed ailments and applying current screening recommendations so that patients receive timely care. In addition to diabetic peripheral neuropathy, she reviewed gastrointestinal and genitourinary autonomic neuropathies, including the use of flibanserin for female sexual dysfunction.

Type 2 Diabetes, Pre-Diabetes, and Reproductive Concerns
Donna Jornsay, MS, BSN, CPNP, BC-ADM, CDE, CDTC, Mills Peninsula Medical Center

Rates of childhood obesity and diabetes are rising, according to Jornsay. In the first of her afternoon sessions, she discussed screening obese children for diabetes, tests that help differentiate type 1 from type 2 DM in children, and some of the nuances of managing this population. For example, T2DM in children is not the same as type 1 or 2 in adults; youngsters are less insulin sensitive at all body mass indices. Jornsay also discussed the reproductive concerns of adults with DM, outlining the prenatal, natal, and postnatal needs of those with type 1 and type 2 diabetes, as well as the neonatal and childhood risks for offspring of those with DM.

Adult Onset Diabetes: Which Type is it?
Ji Hyun (CJ) Chun, PA-C, MPAS, BS-ADM, President, American Society of Endocrine PAs

When signs and symptoms of diabetes beset an adult, how do you know if it’s type 1, type 2, or something else? Chun answered this question through the use of case studies. He reminded that latent autoimmune diabetes in adults (aka type 1.5 or noninsulin-requiring autoimmune diabetes) tends to occur in people who have a personal or family history of autoimmune disease and tends to have a later onset and faster progression to insulin dependence. Secondary diabetes, like type 1, is responsible for about 5% of diabetes diagnoses. Monogenic diabetes, which is often incorrectly diagnosed as type 1 or 2, represents 1% to 2% of DM diagnoses. Chun mentioned that it often takes up to 10 years for a correct diagnosis of monogenic diabetes to be made.

Continue to: Up, Up, and Away! Grounding Glucocorticoid-Induced Hyperglycemia

Up, Up, and Away! Grounding Glucocorticoid-Induced Hyperglycemia
Lucia M. Novak, MSN, ANP-BC, BC-ADM, CDTC, The Uniformed Services University of the Health Sciences

Glucocorticoid-induced hyperglycemia is responsible for 40% to 56% of all inpatient consults with Endocrine Services, according to Novak, which is why it’s important to recognize the pattern of glucocorticoid-induced hyperglycemia. Features include a minimal effect on fasting glucose levels and an exaggeration of insulin resistance that leads to elevated blood glucose levels all day. Once the pattern is identified, next steps, according to Novak, are to determine the insulin product that is best suited to address the pattern, and dose the insulin using a weight-based approach. Prompt recognition and management can help counter the 1.5 to 2.5 odds ratio for developing new onset T2DM.

Key Points to Know for Emerging Adults with Type 1 Diabetes
Donna Jornsay, MS, BSN, CPNP, BC-ADM, CDE, CDTC, Mills Peninsula Medical Center

The prevalence of T1DM increased 23% between 2009 and 2013, according to Jornsay, who added that the number of young people with T1DM is increasing 5% per year. With so many new diagnoses, a new developmental stage was born—that of the emerging adult, who is usually someone aged 18 to 30 years, unmarried, and without children; who is often separated geographically and/or emotionally from family; and who often finds him/herself in a transition of care without focused health care delivery. These patients typically have poor control of glycemia, are at risk for complications, and are often lost to follow-up. Jornsay provided tips on what works in this population.

Tips for Effective Communication in Diabetes Management
Ellen D. Mandel, DMH, MPA, MS, PA-C, RDN, CDE, Pace University, and Donna Jornsay, MS, BSN, CPNP, BC-ADM, CDE, CDTC, Mills Peninsula Medical Center

With 1 in 5 US residents speaking a language other than English at home, Mandel and Jornsay wrapped up the day’s sessions by examining the language of diabetes. In addition to the importance of conveying information about diabetes in a language that’s understood by the patient, they suggested small word choice changes that can help empower patients. For example, instead of referring to patients as diabetics, use the language “people with diabetes.” They reminded that how we talk to, and about, people with diabetes plays an important role in engagement, conceptualization of the disease and its management, treatment outcomes, and the psychosocial well‐being of patients.

Morning session

Case Studies in Type 2 Diabetes: Achieving Goals Together—A Gluco-Patient Centric Approach
Scott Urquhart, PA-C, DFAAPA, James Madison University and George Washington University, and Lucia M. Novak, MSN, ANP-BC, BC-ADM, CDTC, The Uniformed Services University of the Health Sciences

Using case studies, Urquhart and Novak first reviewed how each case would be managed according to the latest American Diabetes Association and American Association of Clinical Endocrinologists guidelines and recommendations and then explained how management might be altered by assuming a more gluco-patient centric approach. The latter, they noted, engages patients as partners in choosing medications and pays special attention to the individual’s concerns and priorities in order to empower patients and optimize outcomes. “Patients come with their own terms/non-negotiables that will ultimately determine therapeutic choices, as well as overall success.” While metformin is a safe and effective first-line therapy choice, it is often necessary and appropriate to consider other agents that address the glycemic goals of the individual patient, possess secondary (nonglycemic) benefits, and are better suited to the patient’s lifestyle, fears, and/or preferences.

Diabetes Medications: Making Co$$tly Decisions
Scott Urquhart, PA-C, DFAAPA, James Madison University and George Washington University, and Lucia M. Novak, MSN, ANP-BC, BC-ADM, CDTC, The Uniformed Services University of the Health Sciences

Urquhart and Novak discussed the financial and clinical impact of barriers that interfere with optimal pharmacologic management of type 2 diabetes mellitus (T2DM) and the importance of evaluating the nonglycemic benefits, such as cardiovascular and renal protection, of diabetes medications when making treatment adjustments. When calculating cost, it is not enough to consider the face price of a drug and the patient’s insurance coverage; the cost equation must factor in the cost (risk to the patient) of complacency and the cost of not maximizing nonglycemic benefits. Complacency, on the part of the clinician, may be caused by clinical inertia; insufficient time, resources, or training; and being overwhelmed with information or confusing guidelines. Complacency on the part of the patient may stem from disease denial, burnout, or distress, or comorbidities. Urquhart and Novak also identified resources available to assist patients with managing medication costs.

Insulin Overview: Which Type and Why?
Davida F. Kruger, MSN, APRN-BC, BC-ADM, Wayne State University and Michigan State University

In reviewing the differences between the basal, prandial, and premixed/biphasic insulin products currently available for the treatment of T2DM in the United States, Kruger emphasized the importance of understanding differences in potency between available products and being able to identify the insulin contained in vials vs pens. Also included in the discussion were differences in physiologic action, pharmacokinetics, dosing, and their pros and cons in various patient populations. Kruger concluded with a look at insulin products on the horizon.

Case Studies continued: Moving Beyond your Comfort Zone
Donna Jornsay, MS, BSN, CPNP, BC-ADM, CDE, CDTC, Mills Peninsula Medical Center, and Davida F. Kruger, MSN, APRN-BC, BC-ADM, Wayne State University and Michigan State University

Using case studies, Jornsay and Kruger reviewed how to choose from among the various insulins available, when and how to initiate and titrate insulin, and the step-wise, trial insulin strategies used for each case before arriving at a treatment approach that worked. They emphasized the importance of recognizing potential barriers to starting insulin and the support and education patients require to be successful. Roadblocks to health care providers providing timely insulin initiation may include concerns about patient adherence, hypoglycemia, pain from glucose monitoring and/or insulin injections, and patient age. Patient roadblocks may include the belief that their T2DM is not sufficiently severe or that insulin will not help.

Continue to: Afternoon session

Afternoon session
Nephrology Secrets: Diabetic Kidney Disease (DKD) and Hypertension
Kim Zuber, PA-C, MS, Executive Director of the American Academy of Nephrology PAs

Zuber focused on the diabetic kidney, noting that 30 million Americans (15% of the population) have chronic kidney disease (CKD), and that many of these don’t know they have it. She talked about the effect of DM on the kidneys, the stages of CKD, and the significance of albumin and of decreasing proteinuria. Switching gears, Zuber then discussed management of patients with diabetes and hypertension, noting that patients with DM are twice as likely to die of cardiovascular disease as those without diabetes, and that CKD occurs 4 times more frequently in patients with hypertension than in those without. While disagreement about target blood pressure goals complicates treatment, she provided tips for step-wise pharmacologic management and for whether an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker should be first-line treatment.

Numb Toes and Other Woes: Diabetic Peripheral and Autonomic Neuropathies
Lucia M. Novak, MSN, ANP-BC, BC-ADM, CDTC, The Uniformed Services University of the Health Sciences

Novak emphasized that early and aggressive glucose stabilization and control is key to minimizing the neuropathic complications affecting patients with diabetes. She discussed recognizing the clinical manifestations of these underdiagnosed ailments and applying current screening recommendations so that patients receive timely care. In addition to diabetic peripheral neuropathy, she reviewed gastrointestinal and genitourinary autonomic neuropathies, including the use of flibanserin for female sexual dysfunction.

Type 2 Diabetes, Pre-Diabetes, and Reproductive Concerns
Donna Jornsay, MS, BSN, CPNP, BC-ADM, CDE, CDTC, Mills Peninsula Medical Center

Rates of childhood obesity and diabetes are rising, according to Jornsay. In the first of her afternoon sessions, she discussed screening obese children for diabetes, tests that help differentiate type 1 from type 2 DM in children, and some of the nuances of managing this population. For example, T2DM in children is not the same as type 1 or 2 in adults; youngsters are less insulin sensitive at all body mass indices. Jornsay also discussed the reproductive concerns of adults with DM, outlining the prenatal, natal, and postnatal needs of those with type 1 and type 2 diabetes, as well as the neonatal and childhood risks for offspring of those with DM.

Adult Onset Diabetes: Which Type is it?
Ji Hyun (CJ) Chun, PA-C, MPAS, BS-ADM, President, American Society of Endocrine PAs

When signs and symptoms of diabetes beset an adult, how do you know if it’s type 1, type 2, or something else? Chun answered this question through the use of case studies. He reminded that latent autoimmune diabetes in adults (aka type 1.5 or noninsulin-requiring autoimmune diabetes) tends to occur in people who have a personal or family history of autoimmune disease and tends to have a later onset and faster progression to insulin dependence. Secondary diabetes, like type 1, is responsible for about 5% of diabetes diagnoses. Monogenic diabetes, which is often incorrectly diagnosed as type 1 or 2, represents 1% to 2% of DM diagnoses. Chun mentioned that it often takes up to 10 years for a correct diagnosis of monogenic diabetes to be made.

Continue to: Up, Up, and Away! Grounding Glucocorticoid-Induced Hyperglycemia

Up, Up, and Away! Grounding Glucocorticoid-Induced Hyperglycemia
Lucia M. Novak, MSN, ANP-BC, BC-ADM, CDTC, The Uniformed Services University of the Health Sciences

Glucocorticoid-induced hyperglycemia is responsible for 40% to 56% of all inpatient consults with Endocrine Services, according to Novak, which is why it’s important to recognize the pattern of glucocorticoid-induced hyperglycemia. Features include a minimal effect on fasting glucose levels and an exaggeration of insulin resistance that leads to elevated blood glucose levels all day. Once the pattern is identified, next steps, according to Novak, are to determine the insulin product that is best suited to address the pattern, and dose the insulin using a weight-based approach. Prompt recognition and management can help counter the 1.5 to 2.5 odds ratio for developing new onset T2DM.

Key Points to Know for Emerging Adults with Type 1 Diabetes
Donna Jornsay, MS, BSN, CPNP, BC-ADM, CDE, CDTC, Mills Peninsula Medical Center

The prevalence of T1DM increased 23% between 2009 and 2013, according to Jornsay, who added that the number of young people with T1DM is increasing 5% per year. With so many new diagnoses, a new developmental stage was born—that of the emerging adult, who is usually someone aged 18 to 30 years, unmarried, and without children; who is often separated geographically and/or emotionally from family; and who often finds him/herself in a transition of care without focused health care delivery. These patients typically have poor control of glycemia, are at risk for complications, and are often lost to follow-up. Jornsay provided tips on what works in this population.

Tips for Effective Communication in Diabetes Management
Ellen D. Mandel, DMH, MPA, MS, PA-C, RDN, CDE, Pace University, and Donna Jornsay, MS, BSN, CPNP, BC-ADM, CDE, CDTC, Mills Peninsula Medical Center

With 1 in 5 US residents speaking a language other than English at home, Mandel and Jornsay wrapped up the day’s sessions by examining the language of diabetes. In addition to the importance of conveying information about diabetes in a language that’s understood by the patient, they suggested small word choice changes that can help empower patients. For example, instead of referring to patients as diabetics, use the language “people with diabetes.” They reminded that how we talk to, and about, people with diabetes plays an important role in engagement, conceptualization of the disease and its management, treatment outcomes, and the psychosocial well‐being of patients.

Morning session

Case Studies in Type 2 Diabetes: Achieving Goals Together—A Gluco-Patient Centric Approach
Scott Urquhart, PA-C, DFAAPA, James Madison University and George Washington University, and Lucia M. Novak, MSN, ANP-BC, BC-ADM, CDTC, The Uniformed Services University of the Health Sciences

Using case studies, Urquhart and Novak first reviewed how each case would be managed according to the latest American Diabetes Association and American Association of Clinical Endocrinologists guidelines and recommendations and then explained how management might be altered by assuming a more gluco-patient centric approach. The latter, they noted, engages patients as partners in choosing medications and pays special attention to the individual’s concerns and priorities in order to empower patients and optimize outcomes. “Patients come with their own terms/non-negotiables that will ultimately determine therapeutic choices, as well as overall success.” While metformin is a safe and effective first-line therapy choice, it is often necessary and appropriate to consider other agents that address the glycemic goals of the individual patient, possess secondary (nonglycemic) benefits, and are better suited to the patient’s lifestyle, fears, and/or preferences.

Diabetes Medications: Making Co$$tly Decisions
Scott Urquhart, PA-C, DFAAPA, James Madison University and George Washington University, and Lucia M. Novak, MSN, ANP-BC, BC-ADM, CDTC, The Uniformed Services University of the Health Sciences

Urquhart and Novak discussed the financial and clinical impact of barriers that interfere with optimal pharmacologic management of type 2 diabetes mellitus (T2DM) and the importance of evaluating the nonglycemic benefits, such as cardiovascular and renal protection, of diabetes medications when making treatment adjustments. When calculating cost, it is not enough to consider the face price of a drug and the patient’s insurance coverage; the cost equation must factor in the cost (risk to the patient) of complacency and the cost of not maximizing nonglycemic benefits. Complacency, on the part of the clinician, may be caused by clinical inertia; insufficient time, resources, or training; and being overwhelmed with information or confusing guidelines. Complacency on the part of the patient may stem from disease denial, burnout, or distress, or comorbidities. Urquhart and Novak also identified resources available to assist patients with managing medication costs.

Insulin Overview: Which Type and Why?
Davida F. Kruger, MSN, APRN-BC, BC-ADM, Wayne State University and Michigan State University

In reviewing the differences between the basal, prandial, and premixed/biphasic insulin products currently available for the treatment of T2DM in the United States, Kruger emphasized the importance of understanding differences in potency between available products and being able to identify the insulin contained in vials vs pens. Also included in the discussion were differences in physiologic action, pharmacokinetics, dosing, and their pros and cons in various patient populations. Kruger concluded with a look at insulin products on the horizon.

Case Studies continued: Moving Beyond your Comfort Zone
Donna Jornsay, MS, BSN, CPNP, BC-ADM, CDE, CDTC, Mills Peninsula Medical Center, and Davida F. Kruger, MSN, APRN-BC, BC-ADM, Wayne State University and Michigan State University

Using case studies, Jornsay and Kruger reviewed how to choose from among the various insulins available, when and how to initiate and titrate insulin, and the step-wise, trial insulin strategies used for each case before arriving at a treatment approach that worked. They emphasized the importance of recognizing potential barriers to starting insulin and the support and education patients require to be successful. Roadblocks to health care providers providing timely insulin initiation may include concerns about patient adherence, hypoglycemia, pain from glucose monitoring and/or insulin injections, and patient age. Patient roadblocks may include the belief that their T2DM is not sufficiently severe or that insulin will not help.

Continue to: Afternoon session

Afternoon session
Nephrology Secrets: Diabetic Kidney Disease (DKD) and Hypertension
Kim Zuber, PA-C, MS, Executive Director of the American Academy of Nephrology PAs

Zuber focused on the diabetic kidney, noting that 30 million Americans (15% of the population) have chronic kidney disease (CKD), and that many of these don’t know they have it. She talked about the effect of DM on the kidneys, the stages of CKD, and the significance of albumin and of decreasing proteinuria. Switching gears, Zuber then discussed management of patients with diabetes and hypertension, noting that patients with DM are twice as likely to die of cardiovascular disease as those without diabetes, and that CKD occurs 4 times more frequently in patients with hypertension than in those without. While disagreement about target blood pressure goals complicates treatment, she provided tips for step-wise pharmacologic management and for whether an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker should be first-line treatment.

Numb Toes and Other Woes: Diabetic Peripheral and Autonomic Neuropathies
Lucia M. Novak, MSN, ANP-BC, BC-ADM, CDTC, The Uniformed Services University of the Health Sciences

Novak emphasized that early and aggressive glucose stabilization and control is key to minimizing the neuropathic complications affecting patients with diabetes. She discussed recognizing the clinical manifestations of these underdiagnosed ailments and applying current screening recommendations so that patients receive timely care. In addition to diabetic peripheral neuropathy, she reviewed gastrointestinal and genitourinary autonomic neuropathies, including the use of flibanserin for female sexual dysfunction.

Type 2 Diabetes, Pre-Diabetes, and Reproductive Concerns
Donna Jornsay, MS, BSN, CPNP, BC-ADM, CDE, CDTC, Mills Peninsula Medical Center

Rates of childhood obesity and diabetes are rising, according to Jornsay. In the first of her afternoon sessions, she discussed screening obese children for diabetes, tests that help differentiate type 1 from type 2 DM in children, and some of the nuances of managing this population. For example, T2DM in children is not the same as type 1 or 2 in adults; youngsters are less insulin sensitive at all body mass indices. Jornsay also discussed the reproductive concerns of adults with DM, outlining the prenatal, natal, and postnatal needs of those with type 1 and type 2 diabetes, as well as the neonatal and childhood risks for offspring of those with DM.

Adult Onset Diabetes: Which Type is it?
Ji Hyun (CJ) Chun, PA-C, MPAS, BS-ADM, President, American Society of Endocrine PAs

When signs and symptoms of diabetes beset an adult, how do you know if it’s type 1, type 2, or something else? Chun answered this question through the use of case studies. He reminded that latent autoimmune diabetes in adults (aka type 1.5 or noninsulin-requiring autoimmune diabetes) tends to occur in people who have a personal or family history of autoimmune disease and tends to have a later onset and faster progression to insulin dependence. Secondary diabetes, like type 1, is responsible for about 5% of diabetes diagnoses. Monogenic diabetes, which is often incorrectly diagnosed as type 1 or 2, represents 1% to 2% of DM diagnoses. Chun mentioned that it often takes up to 10 years for a correct diagnosis of monogenic diabetes to be made.

Continue to: Up, Up, and Away! Grounding Glucocorticoid-Induced Hyperglycemia

Up, Up, and Away! Grounding Glucocorticoid-Induced Hyperglycemia
Lucia M. Novak, MSN, ANP-BC, BC-ADM, CDTC, The Uniformed Services University of the Health Sciences

Glucocorticoid-induced hyperglycemia is responsible for 40% to 56% of all inpatient consults with Endocrine Services, according to Novak, which is why it’s important to recognize the pattern of glucocorticoid-induced hyperglycemia. Features include a minimal effect on fasting glucose levels and an exaggeration of insulin resistance that leads to elevated blood glucose levels all day. Once the pattern is identified, next steps, according to Novak, are to determine the insulin product that is best suited to address the pattern, and dose the insulin using a weight-based approach. Prompt recognition and management can help counter the 1.5 to 2.5 odds ratio for developing new onset T2DM.

Key Points to Know for Emerging Adults with Type 1 Diabetes
Donna Jornsay, MS, BSN, CPNP, BC-ADM, CDE, CDTC, Mills Peninsula Medical Center

The prevalence of T1DM increased 23% between 2009 and 2013, according to Jornsay, who added that the number of young people with T1DM is increasing 5% per year. With so many new diagnoses, a new developmental stage was born—that of the emerging adult, who is usually someone aged 18 to 30 years, unmarried, and without children; who is often separated geographically and/or emotionally from family; and who often finds him/herself in a transition of care without focused health care delivery. These patients typically have poor control of glycemia, are at risk for complications, and are often lost to follow-up. Jornsay provided tips on what works in this population.

Tips for Effective Communication in Diabetes Management
Ellen D. Mandel, DMH, MPA, MS, PA-C, RDN, CDE, Pace University, and Donna Jornsay, MS, BSN, CPNP, BC-ADM, CDE, CDTC, Mills Peninsula Medical Center

With 1 in 5 US residents speaking a language other than English at home, Mandel and Jornsay wrapped up the day’s sessions by examining the language of diabetes. In addition to the importance of conveying information about diabetes in a language that’s understood by the patient, they suggested small word choice changes that can help empower patients. For example, instead of referring to patients as diabetics, use the language “people with diabetes.” They reminded that how we talk to, and about, people with diabetes plays an important role in engagement, conceptualization of the disease and its management, treatment outcomes, and the psychosocial well‐being of patients.

According to surveillance data from the Centers for Disease Control and Prevention (CDC), mortality from drug overdose has steadily increased since the dawn of the new millennium. More than 600,000 overdose deaths were reported from 2000 to 2016. According to the CDC, the first wave began with increased prescribing of opioids in the 1990s and then though the pill mills until approximately 2010. The second wave began shortly thereafter with increased overdose deaths involving heroin as the cost of prescription opioids increased when the pill mills were shut down. The third wave began in 2013 with increased overdose deaths involving synthetic opioids – particularly when illicitly manufactured fentanyl was first used as an additive to Mexican heroin. The illicitly manufactured opioid market continues to change, and is still found in combination with heroin, counterfeit “look-alike opioid prescription medication, spiked marijuana, and now cocaine.

In spite of this changing data, legally prescribed opioid use remains the focus of the most recent opioid “epidemic”. To wit, approximately 63% of the 52,404 overdose deaths in 2015 involved an opioid—but which one? By 2016, the trend was clear– heroin and fentanyl killed the majority of the 42,000 people who overdosed in 2016, more than any year on record. Further, 40% of opioid overdose deaths involved a prescription opioid. This does tell us whether the prescription opioid was attained legally or illegally. Pop star Prince died from an overdose of counterfeit oxycodone tablets, spiked with fentanyl.

Although various strategies have been introduced to address the crisis, including implementation of the CDC Guideline for Prescribing Opioids for Chronic Pain, as well as efforts to improve prescription drug monitoring programs and better access to treatment for opioid use disorder.

Figure 1 CDC Clinical Guidelines for Physicians Prescribing Opioids (CDC 2017):

These recommendations from the CDC are excellent but without adequate training for physicians who deal with chronic pain or addiction on a regular basis, they will likely not produce the change we hope for—and for good reason.  The fear of suspicion and retribution from governing bodies who monitor prescription opioids and all scheduled medications have kept physicians from prescribing these drugs for their patients who need them. Many will recall the latter days of the pill mills, with surveillance videos of sketchy looking characters carrying trash bags full of hydrocodone and oxycodone out of a doctor’s office as part of a covert sting operation–followed by the physician in handcuffs being “perp walked” on the nightly news. These images became iconic in the American psyche and have changed medical practice. Yet for the millions of Americans who suffer from legitimate chronic, non-cancer pain, this is a frightening prospect. Why? Because for most pain patients, opioids have provided a viable means to a quality of life.

The facts are clear; patients with legitimate chronic pain who are cared for by boarded pain or addiction specialists do not abuse their opioid pain medication. In fact, recent data reveal that only between 4 and 10 percent of these patients will ever misuse or abuse their medication. Most of these individuals could not work, achieve self-efficacy, or have any quality of life without the pain relief opioids provide them. We all wish that alternatives were available—but they are not. As the baby boomers are living longer and have more wear and tear and injuries that require expert pain management, there is a legitimate need for these medications—until some alternative to opioids are found. Understandably, many pain patients and their doctors are afraid that government overreach, designed to stop drug dealers and drug addicts, will rob them of the little quality of life they have because opioids provide a temporary respite from severe pain.

In truth, the DEA has done a good job of shutting down the pill mills and most states now allow physicians to access each patient’s pharmacy records online. This process has also shut down “doctor shopping” for controlled substances and takes less than a minute to review all prescriptions for controlled substances for a single patient. Perhaps the epidemic of chronic pain should be the focus of our research efforts.

So why are people still dying from opioid overdose? The CDC report reveals part of the answer. As the pill mills shut down, the price of illicit prescription opioids increased substantially. In response, the Mexican cartel, which was losing billions due to legalized marijuana, flooded the US with cheap, powerful heroin. It was cheap and powerful because the cartel was spiking it with homemade fentanyl, which is approximately 100 times more potent that morphine. It is heroin and fentanyl that are killing thousands of Americans each month.

Cannabis and Pain

Is marijuana really a reasonable alternative to opioids for opioid addicts or for chronic pain? Maybe, but the science is woefully silent on the topic. What little science exists remains inconclusive. The recent JAMA article shows epidemiological trends among Medicare Part D recipients and state Medicaid recipients. The analysis attempts to statistically correlate states with liberal marijuana laws and a decrease in the number of opioid prescriptions written between 2010 and 2015.

Why Does This Matter?

Correlation is not causation. The conclusions reached by this investigation suggest that merely the decline of filling prescriptions for opioids by elderly infirmed adults is due to liberalized, legal access to cannabis, which is quite a reach in logic. This conclusion assumes these same adults voluntarily switched from their opioids to medical marijuana for pain control.  In truth, there are hundreds of variants, including hordes of untrained and anxious physicians who live in fear that prescribing opioids sends a red flag to licensing boards and invites increased scrutiny and potential retribution. Plus, any physician who believes in evidence-based medicine is unlikely to prescribe medical marijuana for pain. At present, the research does not support this practice.

Double blind, placebo-controlled comparisons between medical marijuana and legally prescribed opioids for debilitating non-cancer pain syndromes will provide the science necessary to determine the efficacy and safety of marijuana as a medication for chronic pain.

Yes, it is feasible that the endocannabinoid system may provide new therapeutics for pain and other disease. However, the well-established risks associated with THC must be accounted for. It hard to believe that elderly patients would choose to be stoned for 3-5 hours and experience the cognitive “dulling” and short-term memory deficits over an opioid that if anything, gives them some energy, plus the best pain relief known.

The recent approval of the Cannabidiol (CBD) based medication Epiolidex by an FDA subcommittee, for treating two debilitating seizures disorders, has provided a model for assessing efficacy and risk for cannabis-based medicines. CBD is non-addictive and non-psychoactive.  Until similar scientific scrutiny proves safety and efficacy of THC products, they should be considered harmful.

Reference
Bradford AC, Bradford WD, Abraham A,  Bagwell Adams G . Association Between US State Medical Cannabis Laws and Opioid Prescribing in the Medicare Part D Population. JAMA Intern Med. 2018 Apr 2. doi: 10.1001/jamainternmed.2018.0266. [Epub ahead of print]

According to surveillance data from the Centers for Disease Control and Prevention (CDC), mortality from drug overdose has steadily increased since the dawn of the new millennium. More than 600,000 overdose deaths were reported from 2000 to 2016. According to the CDC, the first wave began with increased prescribing of opioids in the 1990s and then though the pill mills until approximately 2010. The second wave began shortly thereafter with increased overdose deaths involving heroin as the cost of prescription opioids increased when the pill mills were shut down. The third wave began in 2013 with increased overdose deaths involving synthetic opioids – particularly when illicitly manufactured fentanyl was first used as an additive to Mexican heroin. The illicitly manufactured opioid market continues to change, and is still found in combination with heroin, counterfeit “look-alike opioid prescription medication, spiked marijuana, and now cocaine.

In spite of this changing data, legally prescribed opioid use remains the focus of the most recent opioid “epidemic”. To wit, approximately 63% of the 52,404 overdose deaths in 2015 involved an opioid—but which one? By 2016, the trend was clear– heroin and fentanyl killed the majority of the 42,000 people who overdosed in 2016, more than any year on record. Further, 40% of opioid overdose deaths involved a prescription opioid. This does tell us whether the prescription opioid was attained legally or illegally. Pop star Prince died from an overdose of counterfeit oxycodone tablets, spiked with fentanyl.

Although various strategies have been introduced to address the crisis, including implementation of the CDC Guideline for Prescribing Opioids for Chronic Pain, as well as efforts to improve prescription drug monitoring programs and better access to treatment for opioid use disorder.

Figure 1 CDC Clinical Guidelines for Physicians Prescribing Opioids (CDC 2017):

These recommendations from the CDC are excellent but without adequate training for physicians who deal with chronic pain or addiction on a regular basis, they will likely not produce the change we hope for—and for good reason.  The fear of suspicion and retribution from governing bodies who monitor prescription opioids and all scheduled medications have kept physicians from prescribing these drugs for their patients who need them. Many will recall the latter days of the pill mills, with surveillance videos of sketchy looking characters carrying trash bags full of hydrocodone and oxycodone out of a doctor’s office as part of a covert sting operation–followed by the physician in handcuffs being “perp walked” on the nightly news. These images became iconic in the American psyche and have changed medical practice. Yet for the millions of Americans who suffer from legitimate chronic, non-cancer pain, this is a frightening prospect. Why? Because for most pain patients, opioids have provided a viable means to a quality of life.

The facts are clear; patients with legitimate chronic pain who are cared for by boarded pain or addiction specialists do not abuse their opioid pain medication. In fact, recent data reveal that only between 4 and 10 percent of these patients will ever misuse or abuse their medication. Most of these individuals could not work, achieve self-efficacy, or have any quality of life without the pain relief opioids provide them. We all wish that alternatives were available—but they are not. As the baby boomers are living longer and have more wear and tear and injuries that require expert pain management, there is a legitimate need for these medications—until some alternative to opioids are found. Understandably, many pain patients and their doctors are afraid that government overreach, designed to stop drug dealers and drug addicts, will rob them of the little quality of life they have because opioids provide a temporary respite from severe pain.

In truth, the DEA has done a good job of shutting down the pill mills and most states now allow physicians to access each patient’s pharmacy records online. This process has also shut down “doctor shopping” for controlled substances and takes less than a minute to review all prescriptions for controlled substances for a single patient. Perhaps the epidemic of chronic pain should be the focus of our research efforts.

So why are people still dying from opioid overdose? The CDC report reveals part of the answer. As the pill mills shut down, the price of illicit prescription opioids increased substantially. In response, the Mexican cartel, which was losing billions due to legalized marijuana, flooded the US with cheap, powerful heroin. It was cheap and powerful because the cartel was spiking it with homemade fentanyl, which is approximately 100 times more potent that morphine. It is heroin and fentanyl that are killing thousands of Americans each month.

Cannabis and Pain

Is marijuana really a reasonable alternative to opioids for opioid addicts or for chronic pain? Maybe, but the science is woefully silent on the topic. What little science exists remains inconclusive. The recent JAMA article shows epidemiological trends among Medicare Part D recipients and state Medicaid recipients. The analysis attempts to statistically correlate states with liberal marijuana laws and a decrease in the number of opioid prescriptions written between 2010 and 2015.

Why Does This Matter?

Correlation is not causation. The conclusions reached by this investigation suggest that merely the decline of filling prescriptions for opioids by elderly infirmed adults is due to liberalized, legal access to cannabis, which is quite a reach in logic. This conclusion assumes these same adults voluntarily switched from their opioids to medical marijuana for pain control.  In truth, there are hundreds of variants, including hordes of untrained and anxious physicians who live in fear that prescribing opioids sends a red flag to licensing boards and invites increased scrutiny and potential retribution. Plus, any physician who believes in evidence-based medicine is unlikely to prescribe medical marijuana for pain. At present, the research does not support this practice.

Double blind, placebo-controlled comparisons between medical marijuana and legally prescribed opioids for debilitating non-cancer pain syndromes will provide the science necessary to determine the efficacy and safety of marijuana as a medication for chronic pain.

Yes, it is feasible that the endocannabinoid system may provide new therapeutics for pain and other disease. However, the well-established risks associated with THC must be accounted for. It hard to believe that elderly patients would choose to be stoned for 3-5 hours and experience the cognitive “dulling” and short-term memory deficits over an opioid that if anything, gives them some energy, plus the best pain relief known.

The recent approval of the Cannabidiol (CBD) based medication Epiolidex by an FDA subcommittee, for treating two debilitating seizures disorders, has provided a model for assessing efficacy and risk for cannabis-based medicines. CBD is non-addictive and non-psychoactive.  Until similar scientific scrutiny proves safety and efficacy of THC products, they should be considered harmful.

Reference
Bradford AC, Bradford WD, Abraham A,  Bagwell Adams G . Association Between US State Medical Cannabis Laws and Opioid Prescribing in the Medicare Part D Population. JAMA Intern Med. 2018 Apr 2. doi: 10.1001/jamainternmed.2018.0266. [Epub ahead of print]

According to surveillance data from the Centers for Disease Control and Prevention (CDC), mortality from drug overdose has steadily increased since the dawn of the new millennium. More than 600,000 overdose deaths were reported from 2000 to 2016. According to the CDC, the first wave began with increased prescribing of opioids in the 1990s and then though the pill mills until approximately 2010. The second wave began shortly thereafter with increased overdose deaths involving heroin as the cost of prescription opioids increased when the pill mills were shut down. The third wave began in 2013 with increased overdose deaths involving synthetic opioids – particularly when illicitly manufactured fentanyl was first used as an additive to Mexican heroin. The illicitly manufactured opioid market continues to change, and is still found in combination with heroin, counterfeit “look-alike opioid prescription medication, spiked marijuana, and now cocaine.

In spite of this changing data, legally prescribed opioid use remains the focus of the most recent opioid “epidemic”. To wit, approximately 63% of the 52,404 overdose deaths in 2015 involved an opioid—but which one? By 2016, the trend was clear– heroin and fentanyl killed the majority of the 42,000 people who overdosed in 2016, more than any year on record. Further, 40% of opioid overdose deaths involved a prescription opioid. This does tell us whether the prescription opioid was attained legally or illegally. Pop star Prince died from an overdose of counterfeit oxycodone tablets, spiked with fentanyl.

Although various strategies have been introduced to address the crisis, including implementation of the CDC Guideline for Prescribing Opioids for Chronic Pain, as well as efforts to improve prescription drug monitoring programs and better access to treatment for opioid use disorder.

Figure 1 CDC Clinical Guidelines for Physicians Prescribing Opioids (CDC 2017):

These recommendations from the CDC are excellent but without adequate training for physicians who deal with chronic pain or addiction on a regular basis, they will likely not produce the change we hope for—and for good reason.  The fear of suspicion and retribution from governing bodies who monitor prescription opioids and all scheduled medications have kept physicians from prescribing these drugs for their patients who need them. Many will recall the latter days of the pill mills, with surveillance videos of sketchy looking characters carrying trash bags full of hydrocodone and oxycodone out of a doctor’s office as part of a covert sting operation–followed by the physician in handcuffs being “perp walked” on the nightly news. These images became iconic in the American psyche and have changed medical practice. Yet for the millions of Americans who suffer from legitimate chronic, non-cancer pain, this is a frightening prospect. Why? Because for most pain patients, opioids have provided a viable means to a quality of life.

The facts are clear; patients with legitimate chronic pain who are cared for by boarded pain or addiction specialists do not abuse their opioid pain medication. In fact, recent data reveal that only between 4 and 10 percent of these patients will ever misuse or abuse their medication. Most of these individuals could not work, achieve self-efficacy, or have any quality of life without the pain relief opioids provide them. We all wish that alternatives were available—but they are not. As the baby boomers are living longer and have more wear and tear and injuries that require expert pain management, there is a legitimate need for these medications—until some alternative to opioids are found. Understandably, many pain patients and their doctors are afraid that government overreach, designed to stop drug dealers and drug addicts, will rob them of the little quality of life they have because opioids provide a temporary respite from severe pain.

In truth, the DEA has done a good job of shutting down the pill mills and most states now allow physicians to access each patient’s pharmacy records online. This process has also shut down “doctor shopping” for controlled substances and takes less than a minute to review all prescriptions for controlled substances for a single patient. Perhaps the epidemic of chronic pain should be the focus of our research efforts.

So why are people still dying from opioid overdose? The CDC report reveals part of the answer. As the pill mills shut down, the price of illicit prescription opioids increased substantially. In response, the Mexican cartel, which was losing billions due to legalized marijuana, flooded the US with cheap, powerful heroin. It was cheap and powerful because the cartel was spiking it with homemade fentanyl, which is approximately 100 times more potent that morphine. It is heroin and fentanyl that are killing thousands of Americans each month.

Cannabis and Pain

Is marijuana really a reasonable alternative to opioids for opioid addicts or for chronic pain? Maybe, but the science is woefully silent on the topic. What little science exists remains inconclusive. The recent JAMA article shows epidemiological trends among Medicare Part D recipients and state Medicaid recipients. The analysis attempts to statistically correlate states with liberal marijuana laws and a decrease in the number of opioid prescriptions written between 2010 and 2015.

Why Does This Matter?

Correlation is not causation. The conclusions reached by this investigation suggest that merely the decline of filling prescriptions for opioids by elderly infirmed adults is due to liberalized, legal access to cannabis, which is quite a reach in logic. This conclusion assumes these same adults voluntarily switched from their opioids to medical marijuana for pain control.  In truth, there are hundreds of variants, including hordes of untrained and anxious physicians who live in fear that prescribing opioids sends a red flag to licensing boards and invites increased scrutiny and potential retribution. Plus, any physician who believes in evidence-based medicine is unlikely to prescribe medical marijuana for pain. At present, the research does not support this practice.

Double blind, placebo-controlled comparisons between medical marijuana and legally prescribed opioids for debilitating non-cancer pain syndromes will provide the science necessary to determine the efficacy and safety of marijuana as a medication for chronic pain.

Yes, it is feasible that the endocannabinoid system may provide new therapeutics for pain and other disease. However, the well-established risks associated with THC must be accounted for. It hard to believe that elderly patients would choose to be stoned for 3-5 hours and experience the cognitive “dulling” and short-term memory deficits over an opioid that if anything, gives them some energy, plus the best pain relief known.

The recent approval of the Cannabidiol (CBD) based medication Epiolidex by an FDA subcommittee, for treating two debilitating seizures disorders, has provided a model for assessing efficacy and risk for cannabis-based medicines. CBD is non-addictive and non-psychoactive.  Until similar scientific scrutiny proves safety and efficacy of THC products, they should be considered harmful.

Reference
Bradford AC, Bradford WD, Abraham A,  Bagwell Adams G . Association Between US State Medical Cannabis Laws and Opioid Prescribing in the Medicare Part D Population. JAMA Intern Med. 2018 Apr 2. doi: 10.1001/jamainternmed.2018.0266. [Epub ahead of print]

Data from a VA report on its nursing homesshow that the VA’s 132 community living centers compare closely with 15,487 private-sector nursing homes even though the VA on average cares for sicker patients, with a higher proportion of conditions such as spinal cord injury, PTSD, and combat injury: 25.6% of VA nursing homes rated 5 stars (the highest rating), as did 28.7% of private-sector facilities.

The VA report notes that VA nursing homes do not refuse service to any eligible veteran. The fact that they often house residents with more complex medical needs than private-sector facilities will accept “makes achieving good quality ratings more challenging,” the VA says. VA nursing homes at times rate lower than private-sector facilities on specific metrics such as pain and type of treatment.

But the VA has a significantly lower percentage of 1-star (lowest rated) facilities. Moreover, 60 of the VA’s nursing homes improved their quality score in the past year. The report also says VA nursing homes have a higher staff-to-resident ratio than private-sector facilities, meaning residents in VA facilities get more direct attention

Data from a VA report on its nursing homesshow that the VA’s 132 community living centers compare closely with 15,487 private-sector nursing homes even though the VA on average cares for sicker patients, with a higher proportion of conditions such as spinal cord injury, PTSD, and combat injury: 25.6% of VA nursing homes rated 5 stars (the highest rating), as did 28.7% of private-sector facilities.

The VA report notes that VA nursing homes do not refuse service to any eligible veteran. The fact that they often house residents with more complex medical needs than private-sector facilities will accept “makes achieving good quality ratings more challenging,” the VA says. VA nursing homes at times rate lower than private-sector facilities on specific metrics such as pain and type of treatment.

But the VA has a significantly lower percentage of 1-star (lowest rated) facilities. Moreover, 60 of the VA’s nursing homes improved their quality score in the past year. The report also says VA nursing homes have a higher staff-to-resident ratio than private-sector facilities, meaning residents in VA facilities get more direct attention

Data from a VA report on its nursing homesshow that the VA’s 132 community living centers compare closely with 15,487 private-sector nursing homes even though the VA on average cares for sicker patients, with a higher proportion of conditions such as spinal cord injury, PTSD, and combat injury: 25.6% of VA nursing homes rated 5 stars (the highest rating), as did 28.7% of private-sector facilities.

The VA report notes that VA nursing homes do not refuse service to any eligible veteran. The fact that they often house residents with more complex medical needs than private-sector facilities will accept “makes achieving good quality ratings more challenging,” the VA says. VA nursing homes at times rate lower than private-sector facilities on specific metrics such as pain and type of treatment.

But the VA has a significantly lower percentage of 1-star (lowest rated) facilities. Moreover, 60 of the VA’s nursing homes improved their quality score in the past year. The report also says VA nursing homes have a higher staff-to-resident ratio than private-sector facilities, meaning residents in VA facilities get more direct attention

Photo from UAB

Children may have an increased risk of premature death decades after allogeneic hematopoietic stem cell transplant (allo-HSCT), according to a study published in JAMA Oncology.

The leading causes of death in the patients studied were infection and chronic graft-vs-host disease (GVHD), patients’ primary disease, and subsequent cancers.

“This study shows that, while we are able to save the life of the child during their cancer treatment, we need to continue to provide proactive follow-up care with these types of patients throughout the rest of their life, as they are still an at-risk population,” said study author Smita Bhatia, MBBS, of the University of Alabama at Birmingham (UAB).

“The high intensity of therapeutic exposures at a young age lends itself to cause morbidities and organ compromise once they reach adulthood.”

Dr Bhatia and her colleagues conducted this retrospective study of children who underwent allo-HSCT between January 1, 1974, and December 31, 2010, and were followed until December 31, 2016.

The study included 1388 patients who lived 2 years or more after transplant. Their median age at transplant was 14.6 years (range, 0-21). The majority of patients were non-Hispanic white (70.7%), and most were male (59.7%).

Patients underwent allo-HSCT to treat acute lymphoblastic leukemia (ALL, 25.1%), acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS, 23.5%), inborn errors of metabolism (13.8%), severe aplastic anemia (SAA, 10.6%), Fanconi anemia (8.3%), chronic myelogenous leukemia (CML, 6.5%), immune disorders (4%), sickle cell disease or thalassemia (1.9%), and other diseases.

Most patients had a related donor (57.9%), and most received a bone marrow transplant (73.4%).

The most common component of conditioning was cyclophosphamide (80.5%), followed by total body irradiation (TBI, 64.3%). About half of patients (49.8%) received both cyclophosphamide and TBI, and nearly a quarter (23.5%) received busulfan and cyclophosphamide.

Outcomes

The researchers found that allo-HSCT recipients had a 14.4-fold greater risk of premature death than the general population.

The team said the absolute excess risk of all-cause mortality was 12.0 per 1000 person-years, and relative mortality remained elevated 25 years or more after transplant (standardized mortality ratio, 2.9).

At a median follow-up of 14.9 years (range, 2.0 to 41.2), 295 patients had died. The 20-year overall survival rate was 79.3%.

The cause of death was available for 82.7% of patients (244/295), and some of these patients had more than 1 cause listed. Causes of death included:

• Infection and/or chronic GVHD—49.6%
• Primary disease—24.6%
• Subsequent malignant neoplasm—18.4%
• Cardiac disease—9.8%
• Pulmonary disease—7.8%
• External causes—2.9%
• Other causes—18.0%.

The hazard of all-cause late mortality was higher among patients who were older at transplant (hazard ratio [HR], 1.03; P=0.004) and those who had a high risk of relapse at transplant (HR, 1.95; P<0.001).

Compared to patients treated for ALL, the hazard of all-cause late mortality was lower among patients with AML/MDS (HR, 0.72; P=0.04), CML (HR, 0.53; P=0.02), Fanconi anemia (HR, 0.49; P=0.03), immune disorders (HR, 0.32; P=0.006), and SAA (HR, 0.33; P<0.001).

The hazard of all-cause late mortality was lower for patients who received conditioning with busulfan and cyclophosphamide (HR, 0.62; P=0.03) than for those who received TBI and cyclophosphamide.

Compared to patients treated for ALL, the hazard of relapse-related mortality was lower among patients with AML/MDS (HR, 0.39; P=0.01) and SAA (HR, 0.09; P=0.03), and the hazard of non-relapse mortality was lower for patients with SAA (HR, 0.36; P=0.004) and immune disorders (HR, 0.14; P=0.009).

The hazard of non-relapse mortality was higher for patients who were older at transplant (HR, 1.03; P=0.03), patients who received peripheral blood stem cells rather than bone marrow (HR, 2.39; P=0.01), and patients who had a high risk of relapse at transplant (HR, 2.05; P<0.001).

Photo from UAB

Children may have an increased risk of premature death decades after allogeneic hematopoietic stem cell transplant (allo-HSCT), according to a study published in JAMA Oncology.

The leading causes of death in the patients studied were infection and chronic graft-vs-host disease (GVHD), patients’ primary disease, and subsequent cancers.

“This study shows that, while we are able to save the life of the child during their cancer treatment, we need to continue to provide proactive follow-up care with these types of patients throughout the rest of their life, as they are still an at-risk population,” said study author Smita Bhatia, MBBS, of the University of Alabama at Birmingham (UAB).

“The high intensity of therapeutic exposures at a young age lends itself to cause morbidities and organ compromise once they reach adulthood.”

Dr Bhatia and her colleagues conducted this retrospective study of children who underwent allo-HSCT between January 1, 1974, and December 31, 2010, and were followed until December 31, 2016.

The study included 1388 patients who lived 2 years or more after transplant. Their median age at transplant was 14.6 years (range, 0-21). The majority of patients were non-Hispanic white (70.7%), and most were male (59.7%).

Patients underwent allo-HSCT to treat acute lymphoblastic leukemia (ALL, 25.1%), acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS, 23.5%), inborn errors of metabolism (13.8%), severe aplastic anemia (SAA, 10.6%), Fanconi anemia (8.3%), chronic myelogenous leukemia (CML, 6.5%), immune disorders (4%), sickle cell disease or thalassemia (1.9%), and other diseases.

Most patients had a related donor (57.9%), and most received a bone marrow transplant (73.4%).

The most common component of conditioning was cyclophosphamide (80.5%), followed by total body irradiation (TBI, 64.3%). About half of patients (49.8%) received both cyclophosphamide and TBI, and nearly a quarter (23.5%) received busulfan and cyclophosphamide.

Outcomes

The researchers found that allo-HSCT recipients had a 14.4-fold greater risk of premature death than the general population.

The team said the absolute excess risk of all-cause mortality was 12.0 per 1000 person-years, and relative mortality remained elevated 25 years or more after transplant (standardized mortality ratio, 2.9).

At a median follow-up of 14.9 years (range, 2.0 to 41.2), 295 patients had died. The 20-year overall survival rate was 79.3%.

The cause of death was available for 82.7% of patients (244/295), and some of these patients had more than 1 cause listed. Causes of death included:

• Infection and/or chronic GVHD—49.6%
• Primary disease—24.6%
• Subsequent malignant neoplasm—18.4%
• Cardiac disease—9.8%
• Pulmonary disease—7.8%
• External causes—2.9%
• Other causes—18.0%.

The hazard of all-cause late mortality was higher among patients who were older at transplant (hazard ratio [HR], 1.03; P=0.004) and those who had a high risk of relapse at transplant (HR, 1.95; P<0.001).

Compared to patients treated for ALL, the hazard of all-cause late mortality was lower among patients with AML/MDS (HR, 0.72; P=0.04), CML (HR, 0.53; P=0.02), Fanconi anemia (HR, 0.49; P=0.03), immune disorders (HR, 0.32; P=0.006), and SAA (HR, 0.33; P<0.001).

The hazard of all-cause late mortality was lower for patients who received conditioning with busulfan and cyclophosphamide (HR, 0.62; P=0.03) than for those who received TBI and cyclophosphamide.

Compared to patients treated for ALL, the hazard of relapse-related mortality was lower among patients with AML/MDS (HR, 0.39; P=0.01) and SAA (HR, 0.09; P=0.03), and the hazard of non-relapse mortality was lower for patients with SAA (HR, 0.36; P=0.004) and immune disorders (HR, 0.14; P=0.009).

The hazard of non-relapse mortality was higher for patients who were older at transplant (HR, 1.03; P=0.03), patients who received peripheral blood stem cells rather than bone marrow (HR, 2.39; P=0.01), and patients who had a high risk of relapse at transplant (HR, 2.05; P<0.001).

Photo from UAB

Children may have an increased risk of premature death decades after allogeneic hematopoietic stem cell transplant (allo-HSCT), according to a study published in JAMA Oncology.

The leading causes of death in the patients studied were infection and chronic graft-vs-host disease (GVHD), patients’ primary disease, and subsequent cancers.

“This study shows that, while we are able to save the life of the child during their cancer treatment, we need to continue to provide proactive follow-up care with these types of patients throughout the rest of their life, as they are still an at-risk population,” said study author Smita Bhatia, MBBS, of the University of Alabama at Birmingham (UAB).

“The high intensity of therapeutic exposures at a young age lends itself to cause morbidities and organ compromise once they reach adulthood.”

Dr Bhatia and her colleagues conducted this retrospective study of children who underwent allo-HSCT between January 1, 1974, and December 31, 2010, and were followed until December 31, 2016.

The study included 1388 patients who lived 2 years or more after transplant. Their median age at transplant was 14.6 years (range, 0-21). The majority of patients were non-Hispanic white (70.7%), and most were male (59.7%).

Patients underwent allo-HSCT to treat acute lymphoblastic leukemia (ALL, 25.1%), acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS, 23.5%), inborn errors of metabolism (13.8%), severe aplastic anemia (SAA, 10.6%), Fanconi anemia (8.3%), chronic myelogenous leukemia (CML, 6.5%), immune disorders (4%), sickle cell disease or thalassemia (1.9%), and other diseases.

Most patients had a related donor (57.9%), and most received a bone marrow transplant (73.4%).

The most common component of conditioning was cyclophosphamide (80.5%), followed by total body irradiation (TBI, 64.3%). About half of patients (49.8%) received both cyclophosphamide and TBI, and nearly a quarter (23.5%) received busulfan and cyclophosphamide.

Outcomes

The researchers found that allo-HSCT recipients had a 14.4-fold greater risk of premature death than the general population.

The team said the absolute excess risk of all-cause mortality was 12.0 per 1000 person-years, and relative mortality remained elevated 25 years or more after transplant (standardized mortality ratio, 2.9).

At a median follow-up of 14.9 years (range, 2.0 to 41.2), 295 patients had died. The 20-year overall survival rate was 79.3%.

The cause of death was available for 82.7% of patients (244/295), and some of these patients had more than 1 cause listed. Causes of death included:

• Infection and/or chronic GVHD—49.6%
• Primary disease—24.6%
• Subsequent malignant neoplasm—18.4%
• Cardiac disease—9.8%
• Pulmonary disease—7.8%
• External causes—2.9%
• Other causes—18.0%.

The hazard of all-cause late mortality was higher among patients who were older at transplant (hazard ratio [HR], 1.03; P=0.004) and those who had a high risk of relapse at transplant (HR, 1.95; P<0.001).

Compared to patients treated for ALL, the hazard of all-cause late mortality was lower among patients with AML/MDS (HR, 0.72; P=0.04), CML (HR, 0.53; P=0.02), Fanconi anemia (HR, 0.49; P=0.03), immune disorders (HR, 0.32; P=0.006), and SAA (HR, 0.33; P<0.001).

The hazard of all-cause late mortality was lower for patients who received conditioning with busulfan and cyclophosphamide (HR, 0.62; P=0.03) than for those who received TBI and cyclophosphamide.

Compared to patients treated for ALL, the hazard of relapse-related mortality was lower among patients with AML/MDS (HR, 0.39; P=0.01) and SAA (HR, 0.09; P=0.03), and the hazard of non-relapse mortality was lower for patients with SAA (HR, 0.36; P=0.004) and immune disorders (HR, 0.14; P=0.009).

The hazard of non-relapse mortality was higher for patients who were older at transplant (HR, 1.03; P=0.03), patients who received peripheral blood stem cells rather than bone marrow (HR, 2.39; P=0.01), and patients who had a high risk of relapse at transplant (HR, 2.05; P<0.001).

Risky or higher alcohol consumption while breastfeeding could be associated with poorer cognitive outcomes in children, according to a longitudinal cohort study.

©Maxim Tupikov/iStockphoto.com

SOURCE: Gibson L et al. Pediatrics 2018 Jul 30. doi: 10.1542/peds.2017-4266.

Risky or higher alcohol consumption while breastfeeding could be associated with poorer cognitive outcomes in children, according to a longitudinal cohort study.

©Maxim Tupikov/iStockphoto.com

SOURCE: Gibson L et al. Pediatrics 2018 Jul 30. doi: 10.1542/peds.2017-4266.

Risky or higher alcohol consumption while breastfeeding could be associated with poorer cognitive outcomes in children, according to a longitudinal cohort study.

©Maxim Tupikov/iStockphoto.com

SOURCE: Gibson L et al. Pediatrics 2018 Jul 30. doi: 10.1542/peds.2017-4266.

General pediatricians and subspecialists need to provide early and ongoing counseling about infertility and sexual dysfunction for at-risk patients, the American Academy of Pediatrics (AAP) has said in its first-ever clinical report on how to address these potentially sensitive topics.

Examples of pediatric populations at risk for infertility/and or sexual dysfunction include those with hematologic and oncologic disorders such as genitourinary cancer, genetic disorders such as Down syndrome, rheumatologic disorders such as rheumatoid arthritis, and endocrine disorders such as diabetes.

Counseling should include discussion of possible management and psychosocial support options for patients who have conditions or who need treatments that might impair reproductive capacity or sexual functioning, according to the policy statement, published July 30 in Pediatrics.

“We want children to feel safe asking questions, as a lack of information can lead to inaccurate beliefs or distress over time, through young adulthood,” Leena Nahata, MD, a pediatric physician in the endocrinology division at Nationwide Children’s Hospital, Columbus, Ohio, and her coauthors, wrote in an AAP statement.

The policy statement lists five specific recommendations for counseling at-risk pediatric populations on fertility and sexual function:

1. Early discussion is essential, and should start either with parents in infancy, or at the soonest time point where the patient could be affected.

2. “Developmentally sensitive approaches” should be used to deliver complete information about patients’ conditions, accounting for changes in patients’ concerns, perspectives, and comprehension level as they mature.

3. Evidence-based interventions and recommendations should be used, and when evidence is not available, that information needs to be shared with families to facilitate decision-making.

4. Interdisciplinary teams need strategies to discuss risks and interventions in a “direct but sensitive manner” allowing time for questions and considerations; teams also should identify which provider will discuss each risk and potential intervention, and when those discussions will occur.

5. Documentation of discussions and their outcomes are critical to ensure clear communication between health care providers and smooth transition to adult care.

Although team physicians have the best grasp of relevant medical issues, behavioral health specialists are “best equipped” to comprehend cultural, developmental, and family psychosocial issues, and to engage children in decision making, according Dr. Nahata, also affiliated with the Ohio State University, Columbus, and her coauthors.

“By having ongoing discussions, we are more likely to establish a sense of safety and trust, while helping youth and family make informed decisions,” coauthor Amy C. Tishelman, PhD, of the departments of endocrinology and psychiatry, Boston Children’s Hospital and Harvard Medical School, Boston, said in the AAP statement announcing the new guidelines.

Gwendolyn P. Quinn, PhD, of the department of obstetrics and gynecology, New York University Langone Medical Center, served as a third coauthor of the report.

In the AAP statement, Dr. Quinn noted differences in child and adolescent counseling needs, stating that adolescents might express concerns about pregnancy or might need information on contraception to avoid sexually transmitted diseases.

By contrast, detailed discussions about sexual function or fertility might not be appropriate for younger children, who nevertheless might exhibit interest and curiosity in their bodies, and should be made comfortable to ask questions. Open-ended prompts such as “How are you feeling about your body?” could be helpful for children approaching adolescence, according to the policy statement.

Dr. Nahata, Dr. Quinn, and Dr. Tishelman reported that they had no financial relationships relevant to their report, no external funding, and no potential conflicts of interest to disclose.

SOURCE: Nahata L et al. Pediatrics. 2018 Jul 30. doi: 10.1542/peds.2018-1435.

General pediatricians and subspecialists need to provide early and ongoing counseling about infertility and sexual dysfunction for at-risk patients, the American Academy of Pediatrics (AAP) has said in its first-ever clinical report on how to address these potentially sensitive topics.

Examples of pediatric populations at risk for infertility/and or sexual dysfunction include those with hematologic and oncologic disorders such as genitourinary cancer, genetic disorders such as Down syndrome, rheumatologic disorders such as rheumatoid arthritis, and endocrine disorders such as diabetes.

Counseling should include discussion of possible management and psychosocial support options for patients who have conditions or who need treatments that might impair reproductive capacity or sexual functioning, according to the policy statement, published July 30 in Pediatrics.

“We want children to feel safe asking questions, as a lack of information can lead to inaccurate beliefs or distress over time, through young adulthood,” Leena Nahata, MD, a pediatric physician in the endocrinology division at Nationwide Children’s Hospital, Columbus, Ohio, and her coauthors, wrote in an AAP statement.

The policy statement lists five specific recommendations for counseling at-risk pediatric populations on fertility and sexual function:

1. Early discussion is essential, and should start either with parents in infancy, or at the soonest time point where the patient could be affected.

2. “Developmentally sensitive approaches” should be used to deliver complete information about patients’ conditions, accounting for changes in patients’ concerns, perspectives, and comprehension level as they mature.

3. Evidence-based interventions and recommendations should be used, and when evidence is not available, that information needs to be shared with families to facilitate decision-making.

4. Interdisciplinary teams need strategies to discuss risks and interventions in a “direct but sensitive manner” allowing time for questions and considerations; teams also should identify which provider will discuss each risk and potential intervention, and when those discussions will occur.

5. Documentation of discussions and their outcomes are critical to ensure clear communication between health care providers and smooth transition to adult care.

Although team physicians have the best grasp of relevant medical issues, behavioral health specialists are “best equipped” to comprehend cultural, developmental, and family psychosocial issues, and to engage children in decision making, according Dr. Nahata, also affiliated with the Ohio State University, Columbus, and her coauthors.

“By having ongoing discussions, we are more likely to establish a sense of safety and trust, while helping youth and family make informed decisions,” coauthor Amy C. Tishelman, PhD, of the departments of endocrinology and psychiatry, Boston Children’s Hospital and Harvard Medical School, Boston, said in the AAP statement announcing the new guidelines.

Gwendolyn P. Quinn, PhD, of the department of obstetrics and gynecology, New York University Langone Medical Center, served as a third coauthor of the report.

In the AAP statement, Dr. Quinn noted differences in child and adolescent counseling needs, stating that adolescents might express concerns about pregnancy or might need information on contraception to avoid sexually transmitted diseases.

By contrast, detailed discussions about sexual function or fertility might not be appropriate for younger children, who nevertheless might exhibit interest and curiosity in their bodies, and should be made comfortable to ask questions. Open-ended prompts such as “How are you feeling about your body?” could be helpful for children approaching adolescence, according to the policy statement.

Dr. Nahata, Dr. Quinn, and Dr. Tishelman reported that they had no financial relationships relevant to their report, no external funding, and no potential conflicts of interest to disclose.

SOURCE: Nahata L et al. Pediatrics. 2018 Jul 30. doi: 10.1542/peds.2018-1435.

General pediatricians and subspecialists need to provide early and ongoing counseling about infertility and sexual dysfunction for at-risk patients, the American Academy of Pediatrics (AAP) has said in its first-ever clinical report on how to address these potentially sensitive topics.

Examples of pediatric populations at risk for infertility/and or sexual dysfunction include those with hematologic and oncologic disorders such as genitourinary cancer, genetic disorders such as Down syndrome, rheumatologic disorders such as rheumatoid arthritis, and endocrine disorders such as diabetes.

Counseling should include discussion of possible management and psychosocial support options for patients who have conditions or who need treatments that might impair reproductive capacity or sexual functioning, according to the policy statement, published July 30 in Pediatrics.

“We want children to feel safe asking questions, as a lack of information can lead to inaccurate beliefs or distress over time, through young adulthood,” Leena Nahata, MD, a pediatric physician in the endocrinology division at Nationwide Children’s Hospital, Columbus, Ohio, and her coauthors, wrote in an AAP statement.

The policy statement lists five specific recommendations for counseling at-risk pediatric populations on fertility and sexual function:

1. Early discussion is essential, and should start either with parents in infancy, or at the soonest time point where the patient could be affected.

2. “Developmentally sensitive approaches” should be used to deliver complete information about patients’ conditions, accounting for changes in patients’ concerns, perspectives, and comprehension level as they mature.

3. Evidence-based interventions and recommendations should be used, and when evidence is not available, that information needs to be shared with families to facilitate decision-making.

4. Interdisciplinary teams need strategies to discuss risks and interventions in a “direct but sensitive manner” allowing time for questions and considerations; teams also should identify which provider will discuss each risk and potential intervention, and when those discussions will occur.

5. Documentation of discussions and their outcomes are critical to ensure clear communication between health care providers and smooth transition to adult care.

Although team physicians have the best grasp of relevant medical issues, behavioral health specialists are “best equipped” to comprehend cultural, developmental, and family psychosocial issues, and to engage children in decision making, according Dr. Nahata, also affiliated with the Ohio State University, Columbus, and her coauthors.

“By having ongoing discussions, we are more likely to establish a sense of safety and trust, while helping youth and family make informed decisions,” coauthor Amy C. Tishelman, PhD, of the departments of endocrinology and psychiatry, Boston Children’s Hospital and Harvard Medical School, Boston, said in the AAP statement announcing the new guidelines.

Gwendolyn P. Quinn, PhD, of the department of obstetrics and gynecology, New York University Langone Medical Center, served as a third coauthor of the report.

In the AAP statement, Dr. Quinn noted differences in child and adolescent counseling needs, stating that adolescents might express concerns about pregnancy or might need information on contraception to avoid sexually transmitted diseases.

By contrast, detailed discussions about sexual function or fertility might not be appropriate for younger children, who nevertheless might exhibit interest and curiosity in their bodies, and should be made comfortable to ask questions. Open-ended prompts such as “How are you feeling about your body?” could be helpful for children approaching adolescence, according to the policy statement.

Dr. Nahata, Dr. Quinn, and Dr. Tishelman reported that they had no financial relationships relevant to their report, no external funding, and no potential conflicts of interest to disclose.

SOURCE: Nahata L et al. Pediatrics. 2018 Jul 30. doi: 10.1542/peds.2018-1435.