Supplements

Supplement Editor:
Zobair M. Younossi, MD, MPH

Contents

Foreword
Zobair M. Younossi, MD, MPH

The evolving treatment of chronic hepatitis C: Where we stand a decade out
Sherif Saadeh, MD, and Gary L. Davis, MD

Initial treatment for chronic hepatitis C: Current therapies and their optimal dosing and duration
Keyur Patel, MD, and John G. McHutchison, MD

Retreatment of patients who do not respond to initial therapy for chronic hepatitis C
Mitchell L. Shiffman, MD

Managing the hematologic side effects of antiviral therapy for chronic hepatitis C: Anemia, neutropenia, and thrombocytopenia
Janus P. Ong, MD, and Zobair M. Younossi, MD, MPH

The role of hematopoietic growth factors in special populations with chronic hepatitis C: Patients with HIV coinfection, end-stage renal disease, or liver transplantation
Stevan A. Gonzalez, MD, and Ira M. Jacobson, MD

Managing the neuropsychiatric side effects of interferon-based therapy for hepatitis C
Catherine C. Crone, MD; Geoffrey M. Gabriel, MD; and Thomas N. Wise, MD

The role of physician extenders in managing patients with chronic hepatitis C
Harpreet Gujral, RN, MSN, CRNP; Carla Viscomi, RN, BSN; and Rochelle Collantes, MD, MPH

Supplement Editor:
Zobair M. Younossi, MD, MPH

Contents

Foreword
Zobair M. Younossi, MD, MPH

The evolving treatment of chronic hepatitis C: Where we stand a decade out
Sherif Saadeh, MD, and Gary L. Davis, MD

Initial treatment for chronic hepatitis C: Current therapies and their optimal dosing and duration
Keyur Patel, MD, and John G. McHutchison, MD

Retreatment of patients who do not respond to initial therapy for chronic hepatitis C
Mitchell L. Shiffman, MD

Managing the hematologic side effects of antiviral therapy for chronic hepatitis C: Anemia, neutropenia, and thrombocytopenia
Janus P. Ong, MD, and Zobair M. Younossi, MD, MPH

The role of hematopoietic growth factors in special populations with chronic hepatitis C: Patients with HIV coinfection, end-stage renal disease, or liver transplantation
Stevan A. Gonzalez, MD, and Ira M. Jacobson, MD

Managing the neuropsychiatric side effects of interferon-based therapy for hepatitis C
Catherine C. Crone, MD; Geoffrey M. Gabriel, MD; and Thomas N. Wise, MD

The role of physician extenders in managing patients with chronic hepatitis C
Harpreet Gujral, RN, MSN, CRNP; Carla Viscomi, RN, BSN; and Rochelle Collantes, MD, MPH

Supplement Editor:
Zobair M. Younossi, MD, MPH

Contents

Foreword
Zobair M. Younossi, MD, MPH

The evolving treatment of chronic hepatitis C: Where we stand a decade out
Sherif Saadeh, MD, and Gary L. Davis, MD

Initial treatment for chronic hepatitis C: Current therapies and their optimal dosing and duration
Keyur Patel, MD, and John G. McHutchison, MD

Retreatment of patients who do not respond to initial therapy for chronic hepatitis C
Mitchell L. Shiffman, MD

Managing the hematologic side effects of antiviral therapy for chronic hepatitis C: Anemia, neutropenia, and thrombocytopenia
Janus P. Ong, MD, and Zobair M. Younossi, MD, MPH

The role of hematopoietic growth factors in special populations with chronic hepatitis C: Patients with HIV coinfection, end-stage renal disease, or liver transplantation
Stevan A. Gonzalez, MD, and Ira M. Jacobson, MD

Managing the neuropsychiatric side effects of interferon-based therapy for hepatitis C
Catherine C. Crone, MD; Geoffrey M. Gabriel, MD; and Thomas N. Wise, MD

The role of physician extenders in managing patients with chronic hepatitis C
Harpreet Gujral, RN, MSN, CRNP; Carla Viscomi, RN, BSN; and Rochelle Collantes, MD, MPH

Supplement Editors:
Nancy Foldvary-Schaefer, DO, and Martha J. Morrell, MD

Contents

Introduction
Nancy Foldvary-Schaefer, DO, and Martha J. Morrell, MD

Cellular and molecular effects of steroid hormones on CNS excitability
Sheryl S. Smith, PhD, and Catherine S. Woolley, PhD

Hormones and seizures
Nancy Foldvary-Schaefer, DO; Cynthia Harden, MD; Andrew Herzog, MD; and Tommaso Falcone, MD

Reproductive disturbances in patients with epilepsy
Martha J. Morrell, MD, and Georgia D. Montouris, MD

Risks and management of pregnancy in women with epilepsy
Mark S. Yerby, MD, MPH; Peter Kaplan, MB; and Teresa Tran, MD

Neurodevelopmental outcomes of children born to mothers with epilepsy
Kimford J. Meador, MD, and Mary L. Zupanc, MD

Bone disease associated with antiepileptic drugs
Alison M. Pack, MD; Barry Gidal, PharmD; and Blanca Vazquez, MD

Recommendations for the care of women with epilepsy
Patricia E. Penovich, MD; Karen E. Eck, MS, FNP; and Vasiliki V. Economou, MD

Supplement Editors:
Nancy Foldvary-Schaefer, DO, and Martha J. Morrell, MD

Contents

Introduction
Nancy Foldvary-Schaefer, DO, and Martha J. Morrell, MD

Cellular and molecular effects of steroid hormones on CNS excitability
Sheryl S. Smith, PhD, and Catherine S. Woolley, PhD

Hormones and seizures
Nancy Foldvary-Schaefer, DO; Cynthia Harden, MD; Andrew Herzog, MD; and Tommaso Falcone, MD

Reproductive disturbances in patients with epilepsy
Martha J. Morrell, MD, and Georgia D. Montouris, MD

Risks and management of pregnancy in women with epilepsy
Mark S. Yerby, MD, MPH; Peter Kaplan, MB; and Teresa Tran, MD

Neurodevelopmental outcomes of children born to mothers with epilepsy
Kimford J. Meador, MD, and Mary L. Zupanc, MD

Bone disease associated with antiepileptic drugs
Alison M. Pack, MD; Barry Gidal, PharmD; and Blanca Vazquez, MD

Recommendations for the care of women with epilepsy
Patricia E. Penovich, MD; Karen E. Eck, MS, FNP; and Vasiliki V. Economou, MD

Supplement Editors:
Nancy Foldvary-Schaefer, DO, and Martha J. Morrell, MD

Contents

Introduction
Nancy Foldvary-Schaefer, DO, and Martha J. Morrell, MD

Cellular and molecular effects of steroid hormones on CNS excitability
Sheryl S. Smith, PhD, and Catherine S. Woolley, PhD

Hormones and seizures
Nancy Foldvary-Schaefer, DO; Cynthia Harden, MD; Andrew Herzog, MD; and Tommaso Falcone, MD

Reproductive disturbances in patients with epilepsy
Martha J. Morrell, MD, and Georgia D. Montouris, MD

Risks and management of pregnancy in women with epilepsy
Mark S. Yerby, MD, MPH; Peter Kaplan, MB; and Teresa Tran, MD

Neurodevelopmental outcomes of children born to mothers with epilepsy
Kimford J. Meador, MD, and Mary L. Zupanc, MD

Bone disease associated with antiepileptic drugs
Alison M. Pack, MD; Barry Gidal, PharmD; and Blanca Vazquez, MD

Recommendations for the care of women with epilepsy
Patricia E. Penovich, MD; Karen E. Eck, MS, FNP; and Vasiliki V. Economou, MD

Summit Directors and Editors:
Michael A. DeGeorgia, MD; Derk Krieger, MD, PhD; and Anthony Furlan, MD

Contents

Foreword
Michael DeGeorgia, MD

Historical Perspectives: Neurointensive Care

The development of neurologic intensive care
Allan H. Ropper, MD, St. Elizabeth's Medical Center and Tufts University School of Medicine, Boston, MA

Intracranial Pressure

The pathophysiology of brain edema and elevated intracranial pressure
Anthony Marmarou, PhD, Virginia Commonwealth University Medical Center, Richmond, VA

Hypertonic saline for cerebral edema and elevated intracranial pressure
José I. Suarez, MD, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH

Every breath you take: Hyperventilation and intracranial pressure
Claudia Robertson, MD, Baylor College of Medicine, Houston, TX

Multimodal monitoring in neurocritical care
Michael A. DeGeorgia, MD, The Cleveland Clinic Foundation, Cleveland, OH

Hemorrhagic Stroke

Endovascular coiling: The end of conventional neurosurgery?
Peter A. Rasmussen, MD, The Cleveland Clinic Foundation, Cleveland, OH

Fundamentals of Cricital Care

Lessons from the medical and surgical ICU
J. Javier Provencio, MD, The Cleveland Clinic Foundation, Cleveland, OH

Historical Perspectives: Cerebrovascular Disease

Cerebrovascular disease: Historical background, with an eye to the future
Louis R. Caplan, MD, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA

Acute Ischemic Stroke

Pathophysiology of acute ischemic stroke
Midori A. Yenari, MD, Stanford University, Stanford, CA

Intravenous thrombolysis for acute stroke
Joseph P. Broderick, MD, University of Cincinnati College of Medicine, Cincinnati, OH

Intra-arterial thrombolysis for acute stroke
Anthony Furlan, MD, The Cleveland Clinic Foundation, Cleveland, OH

Therapeutic hypothermia may enhance reperfusion in acute ischemic stroke
Derk W. Krieger, MD, PhD, The Cleveland Clinic Foundation, Cleveland, OH

Stem cell transplantation for stroke
Lawrence R. Wechsler, MD, University of Pittsburgh Medical School, Pittsburgh, PA

Extracranial Disease

Carotid artery disease: From knife to stent
Marc R. Mayberg, MD, The Cleveland Clinic Foundation, Cleveland, OH

Carotid stenting in high-risk patients: Design and rationale of the SAPPHIRE trial
Jay S. Yadav, MD, The Cleveland Clinic Foundation, Cleveland, OH

Intracranial Disease

Medical management of intracranial atherosclerosis: Current state of the art
Cathy A. Sila, MD, The Cleveland Clinic Foundation, Cleveland, OH

Intracranial stentings: Which patients and when?
Randall T. Higashida, MD, University of California, San Francisco, Medical Center, San Francisco, CA

Antithrombotic Therapy

Anticoagulation for stroke prevention: Yes, no, maybe
J.P. Mohr, MD, The Neurological Institute, New York, NY

Antiplatelet therapy for acute stroke: Aspirin and beyond
Cathy A. Sila, MD, The Cleveland Clinic Foundation, Cleveland, OH

Abstracts/Poster Presentations

Abstract 1: Hyponatremia-related focal cerebral edema, a mimic of worsening cerebral edema due to intracerebral hemorrhage
P. Widdes-Walsh, V. Sabharwal

Abstract 2: Suboccipital craniectomy for acute cerebellar ischemic stroke
B.R. Cohen, G.L. Bernardini, D. Friedlich, A.J. Popp

Abstract 3: The feasibility and safety of mild brain hypothermia obtained by local surface cooling in acute stroke
K. Yamada, H. Moriwaki, H. Oe, K. Miyashita, K. Nagatsuka, T. Yamawaki, H. Naritomi

Abstract 4: The Diverter, a novel permanent arterial diversion device
J. Leor, Y. Grad, O. Oz, Y. Assaf

Abstract 5: Fatal arrhythmia in an anxious patient during recovery from lateral medullary infarction
J.G. Lattore

Abstract 6: Motor, behavioral, and cognitive changes in patients with thalamic lesions
A.V. Srinivasan, B.S. Virudhagirinathan, C.U. Velmurugendran

Abstract 7: Reversal of locked-in syndrome with anticoagulation, induced hypertension, and intravenous t-PA
K.E. Wartenberg, N.S. Janjua, S.A. Mayer, P. Meyers

Abstract 8: Dantrolene reduces the threshold and gain for shivering
R. Lenhardt

Abstract 9: Predicting outcome after subarachnoid hemorrhage: Comparison of different grading systems
M. Berker, A. Deogaonkar, V. Sabharwal, P. Rasmussen, M. Mayberg, M. DeGeorgia

Abstract 10: Integrative monitoring methods in neurocricital care
A. Deogaonkar, A. Vander Kouwe, K. Horning, R. Burgess, M. DeGerogia

Summit Directors and Editors:
Michael A. DeGeorgia, MD; Derk Krieger, MD, PhD; and Anthony Furlan, MD

Contents

Foreword
Michael DeGeorgia, MD

Historical Perspectives: Neurointensive Care

The development of neurologic intensive care
Allan H. Ropper, MD, St. Elizabeth's Medical Center and Tufts University School of Medicine, Boston, MA

Intracranial Pressure

The pathophysiology of brain edema and elevated intracranial pressure
Anthony Marmarou, PhD, Virginia Commonwealth University Medical Center, Richmond, VA

Hypertonic saline for cerebral edema and elevated intracranial pressure
José I. Suarez, MD, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH

Every breath you take: Hyperventilation and intracranial pressure
Claudia Robertson, MD, Baylor College of Medicine, Houston, TX

Multimodal monitoring in neurocritical care
Michael A. DeGeorgia, MD, The Cleveland Clinic Foundation, Cleveland, OH

Hemorrhagic Stroke

Endovascular coiling: The end of conventional neurosurgery?
Peter A. Rasmussen, MD, The Cleveland Clinic Foundation, Cleveland, OH

Fundamentals of Cricital Care

Lessons from the medical and surgical ICU
J. Javier Provencio, MD, The Cleveland Clinic Foundation, Cleveland, OH

Historical Perspectives: Cerebrovascular Disease

Cerebrovascular disease: Historical background, with an eye to the future
Louis R. Caplan, MD, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA

Acute Ischemic Stroke

Pathophysiology of acute ischemic stroke
Midori A. Yenari, MD, Stanford University, Stanford, CA

Intravenous thrombolysis for acute stroke
Joseph P. Broderick, MD, University of Cincinnati College of Medicine, Cincinnati, OH

Intra-arterial thrombolysis for acute stroke
Anthony Furlan, MD, The Cleveland Clinic Foundation, Cleveland, OH

Therapeutic hypothermia may enhance reperfusion in acute ischemic stroke
Derk W. Krieger, MD, PhD, The Cleveland Clinic Foundation, Cleveland, OH

Stem cell transplantation for stroke
Lawrence R. Wechsler, MD, University of Pittsburgh Medical School, Pittsburgh, PA

Extracranial Disease

Carotid artery disease: From knife to stent
Marc R. Mayberg, MD, The Cleveland Clinic Foundation, Cleveland, OH

Carotid stenting in high-risk patients: Design and rationale of the SAPPHIRE trial
Jay S. Yadav, MD, The Cleveland Clinic Foundation, Cleveland, OH

Intracranial Disease

Medical management of intracranial atherosclerosis: Current state of the art
Cathy A. Sila, MD, The Cleveland Clinic Foundation, Cleveland, OH

Intracranial stentings: Which patients and when?
Randall T. Higashida, MD, University of California, San Francisco, Medical Center, San Francisco, CA

Antithrombotic Therapy

Anticoagulation for stroke prevention: Yes, no, maybe
J.P. Mohr, MD, The Neurological Institute, New York, NY

Antiplatelet therapy for acute stroke: Aspirin and beyond
Cathy A. Sila, MD, The Cleveland Clinic Foundation, Cleveland, OH

Abstracts/Poster Presentations

Abstract 1: Hyponatremia-related focal cerebral edema, a mimic of worsening cerebral edema due to intracerebral hemorrhage
P. Widdes-Walsh, V. Sabharwal

Abstract 2: Suboccipital craniectomy for acute cerebellar ischemic stroke
B.R. Cohen, G.L. Bernardini, D. Friedlich, A.J. Popp

Abstract 3: The feasibility and safety of mild brain hypothermia obtained by local surface cooling in acute stroke
K. Yamada, H. Moriwaki, H. Oe, K. Miyashita, K. Nagatsuka, T. Yamawaki, H. Naritomi

Abstract 4: The Diverter, a novel permanent arterial diversion device
J. Leor, Y. Grad, O. Oz, Y. Assaf

Abstract 5: Fatal arrhythmia in an anxious patient during recovery from lateral medullary infarction
J.G. Lattore

Abstract 6: Motor, behavioral, and cognitive changes in patients with thalamic lesions
A.V. Srinivasan, B.S. Virudhagirinathan, C.U. Velmurugendran

Abstract 7: Reversal of locked-in syndrome with anticoagulation, induced hypertension, and intravenous t-PA
K.E. Wartenberg, N.S. Janjua, S.A. Mayer, P. Meyers

Abstract 8: Dantrolene reduces the threshold and gain for shivering
R. Lenhardt

Abstract 9: Predicting outcome after subarachnoid hemorrhage: Comparison of different grading systems
M. Berker, A. Deogaonkar, V. Sabharwal, P. Rasmussen, M. Mayberg, M. DeGeorgia

Abstract 10: Integrative monitoring methods in neurocricital care
A. Deogaonkar, A. Vander Kouwe, K. Horning, R. Burgess, M. DeGerogia

Summit Directors and Editors:
Michael A. DeGeorgia, MD; Derk Krieger, MD, PhD; and Anthony Furlan, MD

Contents

Foreword
Michael DeGeorgia, MD

Historical Perspectives: Neurointensive Care

The development of neurologic intensive care
Allan H. Ropper, MD, St. Elizabeth's Medical Center and Tufts University School of Medicine, Boston, MA

Intracranial Pressure

The pathophysiology of brain edema and elevated intracranial pressure
Anthony Marmarou, PhD, Virginia Commonwealth University Medical Center, Richmond, VA

Hypertonic saline for cerebral edema and elevated intracranial pressure
José I. Suarez, MD, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH

Every breath you take: Hyperventilation and intracranial pressure
Claudia Robertson, MD, Baylor College of Medicine, Houston, TX

Multimodal monitoring in neurocritical care
Michael A. DeGeorgia, MD, The Cleveland Clinic Foundation, Cleveland, OH

Hemorrhagic Stroke

Endovascular coiling: The end of conventional neurosurgery?
Peter A. Rasmussen, MD, The Cleveland Clinic Foundation, Cleveland, OH

Fundamentals of Cricital Care

Lessons from the medical and surgical ICU
J. Javier Provencio, MD, The Cleveland Clinic Foundation, Cleveland, OH

Historical Perspectives: Cerebrovascular Disease

Cerebrovascular disease: Historical background, with an eye to the future
Louis R. Caplan, MD, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA

Acute Ischemic Stroke

Pathophysiology of acute ischemic stroke
Midori A. Yenari, MD, Stanford University, Stanford, CA

Intravenous thrombolysis for acute stroke
Joseph P. Broderick, MD, University of Cincinnati College of Medicine, Cincinnati, OH

Intra-arterial thrombolysis for acute stroke
Anthony Furlan, MD, The Cleveland Clinic Foundation, Cleveland, OH

Therapeutic hypothermia may enhance reperfusion in acute ischemic stroke
Derk W. Krieger, MD, PhD, The Cleveland Clinic Foundation, Cleveland, OH

Stem cell transplantation for stroke
Lawrence R. Wechsler, MD, University of Pittsburgh Medical School, Pittsburgh, PA

Extracranial Disease

Carotid artery disease: From knife to stent
Marc R. Mayberg, MD, The Cleveland Clinic Foundation, Cleveland, OH

Carotid stenting in high-risk patients: Design and rationale of the SAPPHIRE trial
Jay S. Yadav, MD, The Cleveland Clinic Foundation, Cleveland, OH

Intracranial Disease

Medical management of intracranial atherosclerosis: Current state of the art
Cathy A. Sila, MD, The Cleveland Clinic Foundation, Cleveland, OH

Intracranial stentings: Which patients and when?
Randall T. Higashida, MD, University of California, San Francisco, Medical Center, San Francisco, CA

Antithrombotic Therapy

Anticoagulation for stroke prevention: Yes, no, maybe
J.P. Mohr, MD, The Neurological Institute, New York, NY

Antiplatelet therapy for acute stroke: Aspirin and beyond
Cathy A. Sila, MD, The Cleveland Clinic Foundation, Cleveland, OH

Abstracts/Poster Presentations

Abstract 1: Hyponatremia-related focal cerebral edema, a mimic of worsening cerebral edema due to intracerebral hemorrhage
P. Widdes-Walsh, V. Sabharwal

Abstract 2: Suboccipital craniectomy for acute cerebellar ischemic stroke
B.R. Cohen, G.L. Bernardini, D. Friedlich, A.J. Popp

Abstract 3: The feasibility and safety of mild brain hypothermia obtained by local surface cooling in acute stroke
K. Yamada, H. Moriwaki, H. Oe, K. Miyashita, K. Nagatsuka, T. Yamawaki, H. Naritomi

Abstract 4: The Diverter, a novel permanent arterial diversion device
J. Leor, Y. Grad, O. Oz, Y. Assaf

Abstract 5: Fatal arrhythmia in an anxious patient during recovery from lateral medullary infarction
J.G. Lattore

Abstract 6: Motor, behavioral, and cognitive changes in patients with thalamic lesions
A.V. Srinivasan, B.S. Virudhagirinathan, C.U. Velmurugendran

Abstract 7: Reversal of locked-in syndrome with anticoagulation, induced hypertension, and intravenous t-PA
K.E. Wartenberg, N.S. Janjua, S.A. Mayer, P. Meyers

Abstract 8: Dantrolene reduces the threshold and gain for shivering
R. Lenhardt

Abstract 9: Predicting outcome after subarachnoid hemorrhage: Comparison of different grading systems
M. Berker, A. Deogaonkar, V. Sabharwal, P. Rasmussen, M. Mayberg, M. DeGeorgia

Abstract 10: Integrative monitoring methods in neurocricital care
A. Deogaonkar, A. Vander Kouwe, K. Horning, R. Burgess, M. DeGerogia

Supplement Editor:
Joel E. Richter, MD

Contents

GERD pathogenesis, pathophysiology, and clinical manifestations
Peter J. Kahrilas, MD

Extraesophageal symptoms of GERD
Kenneth R. DeVault, MD

The continuum of GERD complications
M. Brian Fennerty, MD

Profile and assessment of GERD pharmacotherapy
Paul N. Maton, MD

Supplement Editor:
Joel E. Richter, MD

Contents

GERD pathogenesis, pathophysiology, and clinical manifestations
Peter J. Kahrilas, MD

Extraesophageal symptoms of GERD
Kenneth R. DeVault, MD

The continuum of GERD complications
M. Brian Fennerty, MD

Profile and assessment of GERD pharmacotherapy
Paul N. Maton, MD

Supplement Editor:
Joel E. Richter, MD

Contents

GERD pathogenesis, pathophysiology, and clinical manifestations
Peter J. Kahrilas, MD

Extraesophageal symptoms of GERD
Kenneth R. DeVault, MD

The continuum of GERD complications
M. Brian Fennerty, MD

Profile and assessment of GERD pharmacotherapy
Paul N. Maton, MD

Supplement Editor:
William Carey, MD

Contents

The epidemiology and natural history of hepatitis C virus infection
Nizar N. Zein, MD

Tests and screening strategies for the diagnosis of hepatitis C
William Carey, MD

Management of newly diagnosed hepatitis C virus infection
Mark W. Russo, MD, MPH; Steven L. Zacks, MD, MPH; and Michael W. Fried, MD

Treatment options for nonresponders and relapsers to initial therapy for hepatitis C
Marten Duncan, DO, and Zobair Younossi, MD, MPH

Special management challenges in hepatitis C
Jose Martagon, MD, and Steven M. Gordon, MD

Supplement Editor:
William Carey, MD

Contents

The epidemiology and natural history of hepatitis C virus infection
Nizar N. Zein, MD

Tests and screening strategies for the diagnosis of hepatitis C
William Carey, MD

Management of newly diagnosed hepatitis C virus infection
Mark W. Russo, MD, MPH; Steven L. Zacks, MD, MPH; and Michael W. Fried, MD

Treatment options for nonresponders and relapsers to initial therapy for hepatitis C
Marten Duncan, DO, and Zobair Younossi, MD, MPH

Special management challenges in hepatitis C
Jose Martagon, MD, and Steven M. Gordon, MD

Supplement Editor:
William Carey, MD

Contents

The epidemiology and natural history of hepatitis C virus infection
Nizar N. Zein, MD

Tests and screening strategies for the diagnosis of hepatitis C
William Carey, MD

Management of newly diagnosed hepatitis C virus infection
Mark W. Russo, MD, MPH; Steven L. Zacks, MD, MPH; and Michael W. Fried, MD

Treatment options for nonresponders and relapsers to initial therapy for hepatitis C
Marten Duncan, DO, and Zobair Younossi, MD, MPH

Special management challenges in hepatitis C
Jose Martagon, MD, and Steven M. Gordon, MD

Supplement Editor:
Roger M. Mills, MD

Contents

Beyond drugs alone: Pacing, ablation, and surgery for atrial fibrillation
R.M. Mills, MD, MPH

Basic mechanisms of atrial fibrillation
D.R. Van Wagoner, PhD

Current clinical issues in atrial fibrillation
M.K. Chung, MD

Approaches to restoring and maintaining normal sinus rhythm
I. Pharmacologic management: Often insufficient, but still first-line
D.O. Martin, MD, MPH

II. Pacing and devices: Progress toward a preventive role
W. Saliba, MD

III. Surgical approaches: At the 'tipping point'
P.M. McCarthy, MD, and A.M. Gillinov, MD

IV. Catheter ablation: A less invasive path to potential cure
W. Belden, MD; N.F. Marrouche, MD; and A. Natale, MD

Managing chronic atrial fibrillation: Strategies to control symptoms and prevent embolism
D.O. Martin, MD, MPH

Supplement Editor:
Roger M. Mills, MD

Contents

Beyond drugs alone: Pacing, ablation, and surgery for atrial fibrillation
R.M. Mills, MD, MPH

Basic mechanisms of atrial fibrillation
D.R. Van Wagoner, PhD

Current clinical issues in atrial fibrillation
M.K. Chung, MD

Approaches to restoring and maintaining normal sinus rhythm
I. Pharmacologic management: Often insufficient, but still first-line
D.O. Martin, MD, MPH

II. Pacing and devices: Progress toward a preventive role
W. Saliba, MD

III. Surgical approaches: At the 'tipping point'
P.M. McCarthy, MD, and A.M. Gillinov, MD

IV. Catheter ablation: A less invasive path to potential cure
W. Belden, MD; N.F. Marrouche, MD; and A. Natale, MD

Managing chronic atrial fibrillation: Strategies to control symptoms and prevent embolism
D.O. Martin, MD, MPH

Supplement Editor:
Roger M. Mills, MD

Contents

Beyond drugs alone: Pacing, ablation, and surgery for atrial fibrillation
R.M. Mills, MD, MPH

Basic mechanisms of atrial fibrillation
D.R. Van Wagoner, PhD

Current clinical issues in atrial fibrillation
M.K. Chung, MD

Approaches to restoring and maintaining normal sinus rhythm
I. Pharmacologic management: Often insufficient, but still first-line
D.O. Martin, MD, MPH

II. Pacing and devices: Progress toward a preventive role
W. Saliba, MD

III. Surgical approaches: At the 'tipping point'
P.M. McCarthy, MD, and A.M. Gillinov, MD

IV. Catheter ablation: A less invasive path to potential cure
W. Belden, MD; N.F. Marrouche, MD; and A. Natale, MD

Managing chronic atrial fibrillation: Strategies to control symptoms and prevent embolism
D.O. Martin, MD, MPH