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Oncogenic drivers and immunotherapy: staying one step ahead of lung cancer

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Oncogenic drivers and immunotherapy: staying one step ahead of lung cancer
Lung cancer remains the single biggest cause of cancer-related mortality, responsible for nearly a quarter of all deaths.1 Although major breakthroughs in the treatment of the most common form – non-small-cell lung cancer (NSCLC) – have been heralded in the past decade, many challenges remain. Here, we discuss how attempts to address these challenges are the driving force behind a continuing paradigm shift in lung cancer treatment.

 

EGFR and ALK: a model of targeted drug development
The majority of newly diagnosed lung cancers are NSCLC, and about half of those are adenocarcinomas (Figure 1).2 Over the past decade there has been a significant evolution in the understanding and treatment of lung adenocarcinoma, mostly stemming from a greater appreciation of the distinct pathologies and unique molecular signatures of these tumors. Genomic characterization of the molecular signatures has led to the identification of numerous key genetic alterations that drive lung cancer. The dependency of lung tumors on these genetic drivers has enabled the pharmacological development of targeted therapies that exploit this vulnerability...

 

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The Journal of Community and Supportive Oncology - 13(7)
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260-267
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lung cancer, non-small-cell lung cancer, NSCLC, EGFR, ALK, crizotinib, epidermal growth factor receptor, anaplastic lymphoma kinase, gefitinib, nivolumab, pembrolizumab, ipilimumab
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Lung cancer remains the single biggest cause of cancer-related mortality, responsible for nearly a quarter of all deaths.1 Although major breakthroughs in the treatment of the most common form – non-small-cell lung cancer (NSCLC) – have been heralded in the past decade, many challenges remain. Here, we discuss how attempts to address these challenges are the driving force behind a continuing paradigm shift in lung cancer treatment.

 

EGFR and ALK: a model of targeted drug development
The majority of newly diagnosed lung cancers are NSCLC, and about half of those are adenocarcinomas (Figure 1).2 Over the past decade there has been a significant evolution in the understanding and treatment of lung adenocarcinoma, mostly stemming from a greater appreciation of the distinct pathologies and unique molecular signatures of these tumors. Genomic characterization of the molecular signatures has led to the identification of numerous key genetic alterations that drive lung cancer. The dependency of lung tumors on these genetic drivers has enabled the pharmacological development of targeted therapies that exploit this vulnerability...

 

Click on the PDF icon at the top of this introduction to read the full article.

 

Lung cancer remains the single biggest cause of cancer-related mortality, responsible for nearly a quarter of all deaths.1 Although major breakthroughs in the treatment of the most common form – non-small-cell lung cancer (NSCLC) – have been heralded in the past decade, many challenges remain. Here, we discuss how attempts to address these challenges are the driving force behind a continuing paradigm shift in lung cancer treatment.

 

EGFR and ALK: a model of targeted drug development
The majority of newly diagnosed lung cancers are NSCLC, and about half of those are adenocarcinomas (Figure 1).2 Over the past decade there has been a significant evolution in the understanding and treatment of lung adenocarcinoma, mostly stemming from a greater appreciation of the distinct pathologies and unique molecular signatures of these tumors. Genomic characterization of the molecular signatures has led to the identification of numerous key genetic alterations that drive lung cancer. The dependency of lung tumors on these genetic drivers has enabled the pharmacological development of targeted therapies that exploit this vulnerability...

 

Click on the PDF icon at the top of this introduction to read the full article.

 

Issue
The Journal of Community and Supportive Oncology - 13(7)
Issue
The Journal of Community and Supportive Oncology - 13(7)
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260-267
Page Number
260-267
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Oncogenic drivers and immunotherapy: staying one step ahead of lung cancer
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Oncogenic drivers and immunotherapy: staying one step ahead of lung cancer
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lung cancer, non-small-cell lung cancer, NSCLC, EGFR, ALK, crizotinib, epidermal growth factor receptor, anaplastic lymphoma kinase, gefitinib, nivolumab, pembrolizumab, ipilimumab
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A weekly speech and language therapy service for head and neck radiotherapy patients during treatment: maximizing accessibility and efficiency

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A weekly speech and language therapy service for head and neck radiotherapy patients during treatment: maximizing accessibility and efficiency

Background Our hospital did not provide a weekly speech and language therapy (SLT) service for head and neck cancer patients during radiotherapy treatment. SLT is recommended in the international guidelines, but many centers do not offer this service. In the case of our hospital, SLT was not provided because there were no funds to cover the costs of additional staff.

Objectives To create a new service model within a multidisciplinary setting to comply with the international SLT guidelines and without increasing staff. We aimed to measure the accessibility and efficiency of a new model of service delivery at our center both for patients and for the service.

Methods 79 patients were recruited for the study. We followed 1 group of patients (n = 29; observation group) throughout their treatment for 6 weeks to establish if there was a clinical need to offer SLT at the treatment center. A second group of patients (n = 50; intervention group) received a weekly SLT review at the treatment center throughout their radiotherapy. Data collected at the tertiary cancer center for 6 months included: age, gender, tumor site and size, treatment modality, swallowing outcomes, communication outcomes, patient satisfaction, multidisciplinary team feedback, and time efficiency. The observation group did not participate in the intervention group because the data was collected between 2 different groups of participants. However, all participants were referred to their local SLT service at the end of their treatment if that was clinically indicated, regardless of the group they had been in.

Results The proportion of patients accessing SLT services during treatment and the time efficiency of the service were both improved with this model of delivery. The service’s compliance with international guidelines was met. More patients continued with oral intake during their treatment at our center with the new service. Improvements were also reported in communication clarity and communication confidence in the same group.

Conclusion Offering head and neck cancer patients SLT at the same time and place as their radiotherapy treatment improves patient outcomes and increases SLT efficiencies. As this was not a treatment study, further clinical trials are required with regards to functional outcomes.

 

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The Journal of Community and Supportive Oncology - 13(7)
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248-255
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speech and language therapy, SLT, head and neck cancer
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Background Our hospital did not provide a weekly speech and language therapy (SLT) service for head and neck cancer patients during radiotherapy treatment. SLT is recommended in the international guidelines, but many centers do not offer this service. In the case of our hospital, SLT was not provided because there were no funds to cover the costs of additional staff.

Objectives To create a new service model within a multidisciplinary setting to comply with the international SLT guidelines and without increasing staff. We aimed to measure the accessibility and efficiency of a new model of service delivery at our center both for patients and for the service.

Methods 79 patients were recruited for the study. We followed 1 group of patients (n = 29; observation group) throughout their treatment for 6 weeks to establish if there was a clinical need to offer SLT at the treatment center. A second group of patients (n = 50; intervention group) received a weekly SLT review at the treatment center throughout their radiotherapy. Data collected at the tertiary cancer center for 6 months included: age, gender, tumor site and size, treatment modality, swallowing outcomes, communication outcomes, patient satisfaction, multidisciplinary team feedback, and time efficiency. The observation group did not participate in the intervention group because the data was collected between 2 different groups of participants. However, all participants were referred to their local SLT service at the end of their treatment if that was clinically indicated, regardless of the group they had been in.

Results The proportion of patients accessing SLT services during treatment and the time efficiency of the service were both improved with this model of delivery. The service’s compliance with international guidelines was met. More patients continued with oral intake during their treatment at our center with the new service. Improvements were also reported in communication clarity and communication confidence in the same group.

Conclusion Offering head and neck cancer patients SLT at the same time and place as their radiotherapy treatment improves patient outcomes and increases SLT efficiencies. As this was not a treatment study, further clinical trials are required with regards to functional outcomes.

 

Click on the PDF icon at the top of this introduction to read the full article.

 

Background Our hospital did not provide a weekly speech and language therapy (SLT) service for head and neck cancer patients during radiotherapy treatment. SLT is recommended in the international guidelines, but many centers do not offer this service. In the case of our hospital, SLT was not provided because there were no funds to cover the costs of additional staff.

Objectives To create a new service model within a multidisciplinary setting to comply with the international SLT guidelines and without increasing staff. We aimed to measure the accessibility and efficiency of a new model of service delivery at our center both for patients and for the service.

Methods 79 patients were recruited for the study. We followed 1 group of patients (n = 29; observation group) throughout their treatment for 6 weeks to establish if there was a clinical need to offer SLT at the treatment center. A second group of patients (n = 50; intervention group) received a weekly SLT review at the treatment center throughout their radiotherapy. Data collected at the tertiary cancer center for 6 months included: age, gender, tumor site and size, treatment modality, swallowing outcomes, communication outcomes, patient satisfaction, multidisciplinary team feedback, and time efficiency. The observation group did not participate in the intervention group because the data was collected between 2 different groups of participants. However, all participants were referred to their local SLT service at the end of their treatment if that was clinically indicated, regardless of the group they had been in.

Results The proportion of patients accessing SLT services during treatment and the time efficiency of the service were both improved with this model of delivery. The service’s compliance with international guidelines was met. More patients continued with oral intake during their treatment at our center with the new service. Improvements were also reported in communication clarity and communication confidence in the same group.

Conclusion Offering head and neck cancer patients SLT at the same time and place as their radiotherapy treatment improves patient outcomes and increases SLT efficiencies. As this was not a treatment study, further clinical trials are required with regards to functional outcomes.

 

Click on the PDF icon at the top of this introduction to read the full article.

 

Issue
The Journal of Community and Supportive Oncology - 13(7)
Issue
The Journal of Community and Supportive Oncology - 13(7)
Page Number
248-255
Page Number
248-255
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A weekly speech and language therapy service for head and neck radiotherapy patients during treatment: maximizing accessibility and efficiency
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A weekly speech and language therapy service for head and neck radiotherapy patients during treatment: maximizing accessibility and efficiency
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speech and language therapy, SLT, head and neck cancer
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speech and language therapy, SLT, head and neck cancer
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Health care expenditures associated with depression in adults with cancer

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Health care expenditures associated with depression in adults with cancer

Background The rates of depression in adults with cancer have been reported as high as 38%-58%. How depression affects overall health care expenditures in individuals with cancer is an under-researched area.

Objective To estimate excess average total health care expenditures associated with depression in adults with cancer by comparing those with and without depression after controlling for demographic, socioeconomic, access to care, and other health status variables.

Methods Cross-sectional data on 4,766 adult survivors of cancer from 2006-2009 of the nationally representative household survey, Medical Expenditure Panel Survey (MEPS), were used. The patients were older than 21 years. Cancer and depression were identified from the patients’ medical conditions files. Dependent variables consisted of total, inpatient, outpatient, emergency department, prescription drugs, and other expenditures. Ordinary least square (OLS) on logged dollars and generalized linear models with log-link function were performed. All analyses (SAS 9.3 and STATA12) accounted for the complex survey design of the MEPS.

Results Overall, 14% of individuals with cancer reported having depression. In those with cancer and depression, the average annual health care expenditures were $18,401 compared with $12,091 in those without depression. After adjusting for demographic, socioeconomic, access to care, and other health status variables, those with depression had about 31.7% greater total expenditures compared with those without depression. Total, outpatient, and prescription expenditures were higher in individuals with depression than in those without depression. Individuals with cancer and depression were significantly more likely to use emergency departments (adjusted odds ratio, 1.46) compared with their counterparts without depression.

Limitations Cancer patients who died during the reporting year were excluded. The financial burden of depression may have been underestimated because the costs of end-of-life care are high. The burden for each cancer type was not analyzed because of the small sample size.

Conclusion In adults with cancer, those with depression had higher health care utilization and expenditures compared with those without depression.

Funding/sponsorship One author partially supported by the National Institute of General Medical Sciences, U54GM104942.

 

Click on the PDF icon at the top of this introduction to read the full article.

 
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Issue
The Journal of Community and Supportive Oncology - 13(7)
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240-247
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cancer survivors, cancer, depression, health care expenditures, access to care, end-of-life care
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Background The rates of depression in adults with cancer have been reported as high as 38%-58%. How depression affects overall health care expenditures in individuals with cancer is an under-researched area.

Objective To estimate excess average total health care expenditures associated with depression in adults with cancer by comparing those with and without depression after controlling for demographic, socioeconomic, access to care, and other health status variables.

Methods Cross-sectional data on 4,766 adult survivors of cancer from 2006-2009 of the nationally representative household survey, Medical Expenditure Panel Survey (MEPS), were used. The patients were older than 21 years. Cancer and depression were identified from the patients’ medical conditions files. Dependent variables consisted of total, inpatient, outpatient, emergency department, prescription drugs, and other expenditures. Ordinary least square (OLS) on logged dollars and generalized linear models with log-link function were performed. All analyses (SAS 9.3 and STATA12) accounted for the complex survey design of the MEPS.

Results Overall, 14% of individuals with cancer reported having depression. In those with cancer and depression, the average annual health care expenditures were $18,401 compared with $12,091 in those without depression. After adjusting for demographic, socioeconomic, access to care, and other health status variables, those with depression had about 31.7% greater total expenditures compared with those without depression. Total, outpatient, and prescription expenditures were higher in individuals with depression than in those without depression. Individuals with cancer and depression were significantly more likely to use emergency departments (adjusted odds ratio, 1.46) compared with their counterparts without depression.

Limitations Cancer patients who died during the reporting year were excluded. The financial burden of depression may have been underestimated because the costs of end-of-life care are high. The burden for each cancer type was not analyzed because of the small sample size.

Conclusion In adults with cancer, those with depression had higher health care utilization and expenditures compared with those without depression.

Funding/sponsorship One author partially supported by the National Institute of General Medical Sciences, U54GM104942.

 

Click on the PDF icon at the top of this introduction to read the full article.

 

Background The rates of depression in adults with cancer have been reported as high as 38%-58%. How depression affects overall health care expenditures in individuals with cancer is an under-researched area.

Objective To estimate excess average total health care expenditures associated with depression in adults with cancer by comparing those with and without depression after controlling for demographic, socioeconomic, access to care, and other health status variables.

Methods Cross-sectional data on 4,766 adult survivors of cancer from 2006-2009 of the nationally representative household survey, Medical Expenditure Panel Survey (MEPS), were used. The patients were older than 21 years. Cancer and depression were identified from the patients’ medical conditions files. Dependent variables consisted of total, inpatient, outpatient, emergency department, prescription drugs, and other expenditures. Ordinary least square (OLS) on logged dollars and generalized linear models with log-link function were performed. All analyses (SAS 9.3 and STATA12) accounted for the complex survey design of the MEPS.

Results Overall, 14% of individuals with cancer reported having depression. In those with cancer and depression, the average annual health care expenditures were $18,401 compared with $12,091 in those without depression. After adjusting for demographic, socioeconomic, access to care, and other health status variables, those with depression had about 31.7% greater total expenditures compared with those without depression. Total, outpatient, and prescription expenditures were higher in individuals with depression than in those without depression. Individuals with cancer and depression were significantly more likely to use emergency departments (adjusted odds ratio, 1.46) compared with their counterparts without depression.

Limitations Cancer patients who died during the reporting year were excluded. The financial burden of depression may have been underestimated because the costs of end-of-life care are high. The burden for each cancer type was not analyzed because of the small sample size.

Conclusion In adults with cancer, those with depression had higher health care utilization and expenditures compared with those without depression.

Funding/sponsorship One author partially supported by the National Institute of General Medical Sciences, U54GM104942.

 

Click on the PDF icon at the top of this introduction to read the full article.

 
Issue
The Journal of Community and Supportive Oncology - 13(7)
Issue
The Journal of Community and Supportive Oncology - 13(7)
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240-247
Page Number
240-247
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Health care expenditures associated with depression in adults with cancer
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Health care expenditures associated with depression in adults with cancer
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cancer survivors, cancer, depression, health care expenditures, access to care, end-of-life care
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ASCO 2015: from data and learning, to daily practice

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ASCO 2015: from data and learning, to daily practice
The 2015 annual meeting of the American Society for Clinical Oncology, themed “Illumination and innovation: transforming data into learning,” brought together more than 37,000 attendees in Chicago and featured numerous clinical advances that will improve the lives of our cancer patients. That said, to a first-timer, the gathering probably would have felt like an update on using the immune system to fight cancer, despite our more than 30 years of using such strategies. The science behind the development of these promising monoclonal antibodies is outstanding, and the impact will certainly be far reaching.

 

Click on the PDF icon at the top of this introduction to read the full article.

 

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The Journal of Community and Supportive Oncology - 13(7)
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235-236
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monoclonal antibodies, immunotherapy, nivolumab, ipilimumab, metastatic melanoma, PD-L1, programmed cell death ligand-1, docetaxel, advanced prostate cancer, nonsquamous lung cancer, head and neck cancer, HPV-positive, ado-trastuzumab, T-DM1, aspirin, colon cancer
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The 2015 annual meeting of the American Society for Clinical Oncology, themed “Illumination and innovation: transforming data into learning,” brought together more than 37,000 attendees in Chicago and featured numerous clinical advances that will improve the lives of our cancer patients. That said, to a first-timer, the gathering probably would have felt like an update on using the immune system to fight cancer, despite our more than 30 years of using such strategies. The science behind the development of these promising monoclonal antibodies is outstanding, and the impact will certainly be far reaching.

 

Click on the PDF icon at the top of this introduction to read the full article.

 

The 2015 annual meeting of the American Society for Clinical Oncology, themed “Illumination and innovation: transforming data into learning,” brought together more than 37,000 attendees in Chicago and featured numerous clinical advances that will improve the lives of our cancer patients. That said, to a first-timer, the gathering probably would have felt like an update on using the immune system to fight cancer, despite our more than 30 years of using such strategies. The science behind the development of these promising monoclonal antibodies is outstanding, and the impact will certainly be far reaching.

 

Click on the PDF icon at the top of this introduction to read the full article.

 

Issue
The Journal of Community and Supportive Oncology - 13(7)
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The Journal of Community and Supportive Oncology - 13(7)
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235-236
Page Number
235-236
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ASCO 2015: from data and learning, to daily practice
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ASCO 2015: from data and learning, to daily practice
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monoclonal antibodies, immunotherapy, nivolumab, ipilimumab, metastatic melanoma, PD-L1, programmed cell death ligand-1, docetaxel, advanced prostate cancer, nonsquamous lung cancer, head and neck cancer, HPV-positive, ado-trastuzumab, T-DM1, aspirin, colon cancer
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monoclonal antibodies, immunotherapy, nivolumab, ipilimumab, metastatic melanoma, PD-L1, programmed cell death ligand-1, docetaxel, advanced prostate cancer, nonsquamous lung cancer, head and neck cancer, HPV-positive, ado-trastuzumab, T-DM1, aspirin, colon cancer
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David Henry's JCSO podcast, June 2015

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David Henry's JCSO podcast, June 2015

This month, Dr David Henry of The Journal of Community and Supportive Oncology examines the use olaparib, which was recently approved for the treatment of BRCA-mutated advanced ovarian cancer, as well as four Original Research articles that focus on patient care, support, and quality of life. There’s a comparison of the antiemetic efficacy and safety of palonosetron and ondansetron in the prevention of chemotherapy-induced nausea and vomiting in children; a study that looks at the rationale, dosimetric parameters, and preliminary clinical outcomes in patients who undergo postoperative stereotactic radiosurgery with simultaneous integrated boost for brain metastases; an examination of the impact of nurse navigation on the timeliness of diagnostic medical services in patients with newly diagnosed lung cancer; and a study that draws on a novel approach to improving end-of-life care by measuring patterns of care among recently deceased patients. The podcast concludes with a round-up of some recent studies on cardiovascular disease in oncology, including the toxicity of cancer therapy and treatment guidelines from the American Society of Clinical Oncology.

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Olaparib, BRCA-mutated ovarian cancer, palonosetron, ondansetron, chemotherapy-induced nausea and vomiting, CINV, simultaneous integrated boost, SIB, stereotactic radiosurgery, brain metastases, nurse navigation, diagnostic medical services, lung cancer, end-of-life, EoL, cardiovascular disease, CVD, androgen-deprivation therapy, prostate cancer, cerebral microbleeds, CMBs, white matter lesion, WML, superficial vein thrombosis, SVT, deep vein thrombosis, DVT, venous thromboembolism, VTE

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This month, Dr David Henry of The Journal of Community and Supportive Oncology examines the use olaparib, which was recently approved for the treatment of BRCA-mutated advanced ovarian cancer, as well as four Original Research articles that focus on patient care, support, and quality of life. There’s a comparison of the antiemetic efficacy and safety of palonosetron and ondansetron in the prevention of chemotherapy-induced nausea and vomiting in children; a study that looks at the rationale, dosimetric parameters, and preliminary clinical outcomes in patients who undergo postoperative stereotactic radiosurgery with simultaneous integrated boost for brain metastases; an examination of the impact of nurse navigation on the timeliness of diagnostic medical services in patients with newly diagnosed lung cancer; and a study that draws on a novel approach to improving end-of-life care by measuring patterns of care among recently deceased patients. The podcast concludes with a round-up of some recent studies on cardiovascular disease in oncology, including the toxicity of cancer therapy and treatment guidelines from the American Society of Clinical Oncology.

This month, Dr David Henry of The Journal of Community and Supportive Oncology examines the use olaparib, which was recently approved for the treatment of BRCA-mutated advanced ovarian cancer, as well as four Original Research articles that focus on patient care, support, and quality of life. There’s a comparison of the antiemetic efficacy and safety of palonosetron and ondansetron in the prevention of chemotherapy-induced nausea and vomiting in children; a study that looks at the rationale, dosimetric parameters, and preliminary clinical outcomes in patients who undergo postoperative stereotactic radiosurgery with simultaneous integrated boost for brain metastases; an examination of the impact of nurse navigation on the timeliness of diagnostic medical services in patients with newly diagnosed lung cancer; and a study that draws on a novel approach to improving end-of-life care by measuring patterns of care among recently deceased patients. The podcast concludes with a round-up of some recent studies on cardiovascular disease in oncology, including the toxicity of cancer therapy and treatment guidelines from the American Society of Clinical Oncology.

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Olaparib, BRCA-mutated ovarian cancer, palonosetron, ondansetron, chemotherapy-induced nausea and vomiting, CINV, simultaneous integrated boost, SIB, stereotactic radiosurgery, brain metastases, nurse navigation, diagnostic medical services, lung cancer, end-of-life, EoL, cardiovascular disease, CVD, androgen-deprivation therapy, prostate cancer, cerebral microbleeds, CMBs, white matter lesion, WML, superficial vein thrombosis, SVT, deep vein thrombosis, DVT, venous thromboembolism, VTE

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Olaparib, BRCA-mutated ovarian cancer, palonosetron, ondansetron, chemotherapy-induced nausea and vomiting, CINV, simultaneous integrated boost, SIB, stereotactic radiosurgery, brain metastases, nurse navigation, diagnostic medical services, lung cancer, end-of-life, EoL, cardiovascular disease, CVD, androgen-deprivation therapy, prostate cancer, cerebral microbleeds, CMBs, white matter lesion, WML, superficial vein thrombosis, SVT, deep vein thrombosis, DVT, venous thromboembolism, VTE

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Cardiovascular disease in oncology

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Cardiovascular disease in oncology
In the first quarter of 2015, a number of papers that addressed cardiovascular issues in oncology were published. These included studies of the cardiovascular toxicity of cancer therapy, treatment guidelines from the American Society of Clinical Oncology (ASCO) for venous thromboembolism prophylaxis (VTE), and the prognostic significance of superficial vein thrombosis. 

 

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The Journal of Community and Supportive Oncology - 13(6)
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231-234
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cardiovascular disease, CVD, cardiovascular toxicity, venous thromboembolism, VTE, superficial vein thrombosis, SVT, prostate cancer, cerebral microbleeds, CMBs, whitematter lesions, WMLs, vascular adverse events, VAEs, nilotinib, ponatinib, bosutinib, dasatinib

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In the first quarter of 2015, a number of papers that addressed cardiovascular issues in oncology were published. These included studies of the cardiovascular toxicity of cancer therapy, treatment guidelines from the American Society of Clinical Oncology (ASCO) for venous thromboembolism prophylaxis (VTE), and the prognostic significance of superficial vein thrombosis. 

 

Click on the PDF icon at the top of this introduction to read the full article.

 

In the first quarter of 2015, a number of papers that addressed cardiovascular issues in oncology were published. These included studies of the cardiovascular toxicity of cancer therapy, treatment guidelines from the American Society of Clinical Oncology (ASCO) for venous thromboembolism prophylaxis (VTE), and the prognostic significance of superficial vein thrombosis. 

 

Click on the PDF icon at the top of this introduction to read the full article.

 

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The Journal of Community and Supportive Oncology - 13(6)
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The Journal of Community and Supportive Oncology - 13(6)
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231-234
Page Number
231-234
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Cardiovascular disease in oncology
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Cardiovascular disease in oncology
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cardiovascular disease, CVD, cardiovascular toxicity, venous thromboembolism, VTE, superficial vein thrombosis, SVT, prostate cancer, cerebral microbleeds, CMBs, whitematter lesions, WMLs, vascular adverse events, VAEs, nilotinib, ponatinib, bosutinib, dasatinib

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cardiovascular disease, CVD, cardiovascular toxicity, venous thromboembolism, VTE, superficial vein thrombosis, SVT, prostate cancer, cerebral microbleeds, CMBs, whitematter lesions, WMLs, vascular adverse events, VAEs, nilotinib, ponatinib, bosutinib, dasatinib

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Measuring end-of-life care in oncology practices: learning from the care of the dying

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Measuring end-of-life care in oncology practices: learning from the care of the dying

Background There is increased interest among oncology and palliative professionals in providing appropriately timed hospice services for cancer patients. End of life (EoL) metrics have been included in oncology quality programs, but accurate EoL data and benchmarks are hard to obtain.

Objective To improve EoL care by measuring patterns of care among recently deceased patients.

Methods Care utilization among deceased patients was analyzed by using software integrated with patient electronic health records. The data was verified by chart review.

Results Of 179 cancer deaths, tumor registry data differed from chart review in 7% of cases with regard to dates and/or location of death. Institutional EoL metrics were significantly affected by a large number of patients (37%) with advanced illnesses who had clinical diagnoses of cancer made at the end of life, but who had not been managed by oncologists. This population of patients who had not been managed by oncologists was older, less likely to use hospice, and more likely to use the intensive care unit than were oncologist-managed cancer patients. Among the patients of individual oncologists, the median stay in hospice ranged from 6-28 days. Data collection and chart review took an average of 27 minutes per case with combined efforts by a data analyst and oncology practitioner.

Limitations Single institution with comprehensive electronic medical record; some patients were treated outside of the system.

Conclusion Acquiring accurate data on EoL metrics is time consuming. Compared with chart review, other data sources have inaccuracies and include some patients who have not been managed by oncologists. Accurate attribution to individual physicians requires chart review by an experienced clinician.

 

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The Journal of Community and Supportive Oncology - 13(6)
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225-228
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end of life, EoL, care utilization, location of death, hospice
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Background There is increased interest among oncology and palliative professionals in providing appropriately timed hospice services for cancer patients. End of life (EoL) metrics have been included in oncology quality programs, but accurate EoL data and benchmarks are hard to obtain.

Objective To improve EoL care by measuring patterns of care among recently deceased patients.

Methods Care utilization among deceased patients was analyzed by using software integrated with patient electronic health records. The data was verified by chart review.

Results Of 179 cancer deaths, tumor registry data differed from chart review in 7% of cases with regard to dates and/or location of death. Institutional EoL metrics were significantly affected by a large number of patients (37%) with advanced illnesses who had clinical diagnoses of cancer made at the end of life, but who had not been managed by oncologists. This population of patients who had not been managed by oncologists was older, less likely to use hospice, and more likely to use the intensive care unit than were oncologist-managed cancer patients. Among the patients of individual oncologists, the median stay in hospice ranged from 6-28 days. Data collection and chart review took an average of 27 minutes per case with combined efforts by a data analyst and oncology practitioner.

Limitations Single institution with comprehensive electronic medical record; some patients were treated outside of the system.

Conclusion Acquiring accurate data on EoL metrics is time consuming. Compared with chart review, other data sources have inaccuracies and include some patients who have not been managed by oncologists. Accurate attribution to individual physicians requires chart review by an experienced clinician.

 

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Background There is increased interest among oncology and palliative professionals in providing appropriately timed hospice services for cancer patients. End of life (EoL) metrics have been included in oncology quality programs, but accurate EoL data and benchmarks are hard to obtain.

Objective To improve EoL care by measuring patterns of care among recently deceased patients.

Methods Care utilization among deceased patients was analyzed by using software integrated with patient electronic health records. The data was verified by chart review.

Results Of 179 cancer deaths, tumor registry data differed from chart review in 7% of cases with regard to dates and/or location of death. Institutional EoL metrics were significantly affected by a large number of patients (37%) with advanced illnesses who had clinical diagnoses of cancer made at the end of life, but who had not been managed by oncologists. This population of patients who had not been managed by oncologists was older, less likely to use hospice, and more likely to use the intensive care unit than were oncologist-managed cancer patients. Among the patients of individual oncologists, the median stay in hospice ranged from 6-28 days. Data collection and chart review took an average of 27 minutes per case with combined efforts by a data analyst and oncology practitioner.

Limitations Single institution with comprehensive electronic medical record; some patients were treated outside of the system.

Conclusion Acquiring accurate data on EoL metrics is time consuming. Compared with chart review, other data sources have inaccuracies and include some patients who have not been managed by oncologists. Accurate attribution to individual physicians requires chart review by an experienced clinician.

 

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Issue
The Journal of Community and Supportive Oncology - 13(6)
Issue
The Journal of Community and Supportive Oncology - 13(6)
Page Number
225-228
Page Number
225-228
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Measuring end-of-life care in oncology practices: learning from the care of the dying
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Measuring end-of-life care in oncology practices: learning from the care of the dying
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end of life, EoL, care utilization, location of death, hospice
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Isolated splenic metastasis in a patient with two distinct genitourinary malignancies

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Isolated splenic metastasis in a patient with two distinct genitourinary malignancies
Splenic metastasis is rare, occurring in 2.3%- 7.1% of cases, of which 95% are carcinomas.1 The lung is the most common primary tumor site (21% of cases), followed by the gastrointestinal system, breast, ovaries, and skin. In a retrospective study evaluating the clinical and pathological impact of splenic metastases during a 25-year period in China, it was found that about 5.3% of metastases were isolated splenic metastasis.2  Isolated splenic metastasis from kidney cancer is very rare and is often an incidental finding. Here we report a case with isolated splenic metastasis in a patient with both primary renal cell carcinoma and prostate cancer, which turned out to be metastatic renal cell carcinoma in the spleen.  

 

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The Journal of Community and Supportive Oncology - 13(6)
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229-230
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splenic metastasis, renal cell carcinoma, prostate cancer, metastatic renal cell carcinoma, spleen
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Splenic metastasis is rare, occurring in 2.3%- 7.1% of cases, of which 95% are carcinomas.1 The lung is the most common primary tumor site (21% of cases), followed by the gastrointestinal system, breast, ovaries, and skin. In a retrospective study evaluating the clinical and pathological impact of splenic metastases during a 25-year period in China, it was found that about 5.3% of metastases were isolated splenic metastasis.2  Isolated splenic metastasis from kidney cancer is very rare and is often an incidental finding. Here we report a case with isolated splenic metastasis in a patient with both primary renal cell carcinoma and prostate cancer, which turned out to be metastatic renal cell carcinoma in the spleen.  

 

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Splenic metastasis is rare, occurring in 2.3%- 7.1% of cases, of which 95% are carcinomas.1 The lung is the most common primary tumor site (21% of cases), followed by the gastrointestinal system, breast, ovaries, and skin. In a retrospective study evaluating the clinical and pathological impact of splenic metastases during a 25-year period in China, it was found that about 5.3% of metastases were isolated splenic metastasis.2  Isolated splenic metastasis from kidney cancer is very rare and is often an incidental finding. Here we report a case with isolated splenic metastasis in a patient with both primary renal cell carcinoma and prostate cancer, which turned out to be metastatic renal cell carcinoma in the spleen.  

 

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The Journal of Community and Supportive Oncology - 13(6)
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The Journal of Community and Supportive Oncology - 13(6)
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229-230
Page Number
229-230
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Isolated splenic metastasis in a patient with two distinct genitourinary malignancies
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Isolated splenic metastasis in a patient with two distinct genitourinary malignancies
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splenic metastasis, renal cell carcinoma, prostate cancer, metastatic renal cell carcinoma, spleen
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Impact of nurse navigation on timeliness of diagnostic medical services in patients with newly diagnosed lung cancer

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Background The Summa Cancer Institute in Akron, Ohio, sought to improve access to and the timeliness of lung cancer care by hiring an oncology-certified nurse navigator. The nurse navigator was charged with coordinating diagnostic procedures and specialty oncology consultations, and with facilitating a multidisciplinary thoracic oncology tumor board.

Objective To test the hypothesis that nurse navigation would improve the timeliness of and access to diagnostic medical services among men and women with newly diagnosed lung cancer.

Methods A conducted a retrospective review of 460 patients with lung cancer to evaluate access to care and the timeliness of the care received in the non-navigated and nurse-navigated cohorts.

Results During December 2009-September 2013, the time between the suspicion of cancer on chest X-ray to treatment was 64 days. During October 2013-March 2014, the nurse navigator helped reduce that timespan to 45 days (P < .001).

Limitations Long-term follow-up on clinical outcomes remains premature.

Conclusion This finding attests to the successful implementation of nurse navigation to improve access and timeliness of lung cancer care in a community oncology practice.

 

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The Journal of Community and Supportive Oncology - 13(6)
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219-224
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lung cancer, nurse navigator, access to care, diagnostic services
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Background The Summa Cancer Institute in Akron, Ohio, sought to improve access to and the timeliness of lung cancer care by hiring an oncology-certified nurse navigator. The nurse navigator was charged with coordinating diagnostic procedures and specialty oncology consultations, and with facilitating a multidisciplinary thoracic oncology tumor board.

Objective To test the hypothesis that nurse navigation would improve the timeliness of and access to diagnostic medical services among men and women with newly diagnosed lung cancer.

Methods A conducted a retrospective review of 460 patients with lung cancer to evaluate access to care and the timeliness of the care received in the non-navigated and nurse-navigated cohorts.

Results During December 2009-September 2013, the time between the suspicion of cancer on chest X-ray to treatment was 64 days. During October 2013-March 2014, the nurse navigator helped reduce that timespan to 45 days (P < .001).

Limitations Long-term follow-up on clinical outcomes remains premature.

Conclusion This finding attests to the successful implementation of nurse navigation to improve access and timeliness of lung cancer care in a community oncology practice.

 

Click on the PDF icon at the top of this introduction to read the full article.

Background The Summa Cancer Institute in Akron, Ohio, sought to improve access to and the timeliness of lung cancer care by hiring an oncology-certified nurse navigator. The nurse navigator was charged with coordinating diagnostic procedures and specialty oncology consultations, and with facilitating a multidisciplinary thoracic oncology tumor board.

Objective To test the hypothesis that nurse navigation would improve the timeliness of and access to diagnostic medical services among men and women with newly diagnosed lung cancer.

Methods A conducted a retrospective review of 460 patients with lung cancer to evaluate access to care and the timeliness of the care received in the non-navigated and nurse-navigated cohorts.

Results During December 2009-September 2013, the time between the suspicion of cancer on chest X-ray to treatment was 64 days. During October 2013-March 2014, the nurse navigator helped reduce that timespan to 45 days (P < .001).

Limitations Long-term follow-up on clinical outcomes remains premature.

Conclusion This finding attests to the successful implementation of nurse navigation to improve access and timeliness of lung cancer care in a community oncology practice.

 

Click on the PDF icon at the top of this introduction to read the full article.

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The Journal of Community and Supportive Oncology - 13(6)
Issue
The Journal of Community and Supportive Oncology - 13(6)
Page Number
219-224
Page Number
219-224
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lung cancer, nurse navigator, access to care, diagnostic services
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Simultaneous integrated boost using stereotactic radiosurgery for resected brain metastases: rationale, dosimetric parameters, and preliminary clinical outcomes

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Simultaneous integrated boost using stereotactic radiosurgery for resected brain metastases: rationale, dosimetric parameters, and preliminary clinical outcomes
Background Radiosurgery has been shown to reduce the rates of local recurrence in the postoperative bed after the resection of brain metastases, but the ideal radiation dose has not been well defined.

 

Objective To present dosimetric parameters and preliminary clinical outcomes for patients undergoing postoperative stereotactic radiosurgery (SRS) with simultaneous integrated boost (SIB) for brain metastases.

 

Methods and materials 3 patients underwent surgery for a dominant metastatic focus and had residual or recurrent disease in the resection cavity. Our technique delivered a low dose to the resection cavity with an SIB dose to the gross tumor. Clinical target volume (CTV) was the magnetic resonance (MR)-defined resection cavity. Gross tumor volume (GTV) was the MR-defined residual disease. No additional margin was added to either the resection cavity or the residual disease area. Doses ranged from 14-15 Gy for CTV and 17-18 Gy for GTV prescribed to the 71%-78% isodose line. A traditional postoperative radiosurgery plan was constructed for each patient, and dosimetric values were compared using the paired t-test.

 

Results 3 patients were treated at our institution using SRS with SIB. No patient experienced local recurrence. 2 patients developed distant brain failure (mean, 3.5 months). No grade 3 or greater toxicities were observed. The volume of brain receiving 12 Gy was significantly reduced using SIB compared with traditional postoperative SRS (P = .04). There were no differences in the maximum dose delivered to the tumor (P = .15) and cavity (P = .13). The average mean cavity dose was 16.20 Gy using the SIB plan, compared with 19.71 Gy using the traditional plan (P = .05).

 

Conclusions In patients with either recurrent or residual disease following surgical resection, SRS using SIB is technically feasible and safe.  

 

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The Journal of Community and Supportive Oncology - 13(6)
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214-218
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brain metastases, radiosurgery, stereotactic radiosurgery, SRS, simultaneous integrated boost, SIB, gross tumor volume, GTV
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Background Radiosurgery has been shown to reduce the rates of local recurrence in the postoperative bed after the resection of brain metastases, but the ideal radiation dose has not been well defined.

 

Objective To present dosimetric parameters and preliminary clinical outcomes for patients undergoing postoperative stereotactic radiosurgery (SRS) with simultaneous integrated boost (SIB) for brain metastases.

 

Methods and materials 3 patients underwent surgery for a dominant metastatic focus and had residual or recurrent disease in the resection cavity. Our technique delivered a low dose to the resection cavity with an SIB dose to the gross tumor. Clinical target volume (CTV) was the magnetic resonance (MR)-defined resection cavity. Gross tumor volume (GTV) was the MR-defined residual disease. No additional margin was added to either the resection cavity or the residual disease area. Doses ranged from 14-15 Gy for CTV and 17-18 Gy for GTV prescribed to the 71%-78% isodose line. A traditional postoperative radiosurgery plan was constructed for each patient, and dosimetric values were compared using the paired t-test.

 

Results 3 patients were treated at our institution using SRS with SIB. No patient experienced local recurrence. 2 patients developed distant brain failure (mean, 3.5 months). No grade 3 or greater toxicities were observed. The volume of brain receiving 12 Gy was significantly reduced using SIB compared with traditional postoperative SRS (P = .04). There were no differences in the maximum dose delivered to the tumor (P = .15) and cavity (P = .13). The average mean cavity dose was 16.20 Gy using the SIB plan, compared with 19.71 Gy using the traditional plan (P = .05).

 

Conclusions In patients with either recurrent or residual disease following surgical resection, SRS using SIB is technically feasible and safe.  

 

Click on the PDF icon at the top of this introduction to read the full article.

 

Background Radiosurgery has been shown to reduce the rates of local recurrence in the postoperative bed after the resection of brain metastases, but the ideal radiation dose has not been well defined.

 

Objective To present dosimetric parameters and preliminary clinical outcomes for patients undergoing postoperative stereotactic radiosurgery (SRS) with simultaneous integrated boost (SIB) for brain metastases.

 

Methods and materials 3 patients underwent surgery for a dominant metastatic focus and had residual or recurrent disease in the resection cavity. Our technique delivered a low dose to the resection cavity with an SIB dose to the gross tumor. Clinical target volume (CTV) was the magnetic resonance (MR)-defined resection cavity. Gross tumor volume (GTV) was the MR-defined residual disease. No additional margin was added to either the resection cavity or the residual disease area. Doses ranged from 14-15 Gy for CTV and 17-18 Gy for GTV prescribed to the 71%-78% isodose line. A traditional postoperative radiosurgery plan was constructed for each patient, and dosimetric values were compared using the paired t-test.

 

Results 3 patients were treated at our institution using SRS with SIB. No patient experienced local recurrence. 2 patients developed distant brain failure (mean, 3.5 months). No grade 3 or greater toxicities were observed. The volume of brain receiving 12 Gy was significantly reduced using SIB compared with traditional postoperative SRS (P = .04). There were no differences in the maximum dose delivered to the tumor (P = .15) and cavity (P = .13). The average mean cavity dose was 16.20 Gy using the SIB plan, compared with 19.71 Gy using the traditional plan (P = .05).

 

Conclusions In patients with either recurrent or residual disease following surgical resection, SRS using SIB is technically feasible and safe.  

 

Click on the PDF icon at the top of this introduction to read the full article.

 

Issue
The Journal of Community and Supportive Oncology - 13(6)
Issue
The Journal of Community and Supportive Oncology - 13(6)
Page Number
214-218
Page Number
214-218
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Simultaneous integrated boost using stereotactic radiosurgery for resected brain metastases: rationale, dosimetric parameters, and preliminary clinical outcomes
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Simultaneous integrated boost using stereotactic radiosurgery for resected brain metastases: rationale, dosimetric parameters, and preliminary clinical outcomes
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brain metastases, radiosurgery, stereotactic radiosurgery, SRS, simultaneous integrated boost, SIB, gross tumor volume, GTV
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