News

Women veterans who live in rural areas face multifaceted challenges in managing chronic pain. Some barriers are logistical, including distance from health care facilities and the time required to get there, while others are financial, such as the cost of gas. Researchers from the Veterans Rural Health Resource Center and the Iowa City Veterans Affairs (VA) Health Care System designed a telehealth intervention specifically for rural women. What the study revealed was that social interactions and camaraderie may be just as important in reducing pain as gentle exercise and behavioral changes.

The participants, recruited from a Midwestern VA health care system, were dealing with chronic pain. In baseline measurements, average scores on the Pain, Enjoyment of Life, and General Activity three-item scale (PEG-3) indicated severe pain and functional interference. Notably, the researchers point out, rural women veterans with chronic pain are less likely than urban veterans to receive specialty pain care.

The researchers designed a program of pain self-management options, allowing the participants to sample from a range of empirically supported approaches in one easily accessible format. The program was primarily delivered over video, to support group processes as well as access to video-based components of the intervention (such as yoga lessons) or to display pages from the participant manual for in-session review. The researchers planned it as a women-only space, to provide a “psychologically safe, gender-sensitive, empowering environment.” 

Eight weekly 90-minute sessions featured mindful movement (gentle yoga, graduated walking), peer connection and support, and an introduction to an evidence-based pain or lifestyle self-management topic such as nutrition. The program also included content based on previous work in chronic pain including acceptance and commitment therapy, cognitive behavioral therapy, and dialectical behavior therapy.

Of the 44 participants, 84% completed the intervention. About half of treatment completers (47%) were deemed responders, reporting a ≥ 30% reduction on their PEG-3 total scores. On the Global Impression of Change scale, 87% reported improvement. 

Of the 30 participants who provided follow-up data, 94% were satisfied or very satisfied; no one reported being dissatisfied with the intervention. 

In qualitative interviews, though, the researchers say a clear theme emerged, reflecting the impact and benefit of the balance of three social and psychological components: rapport with facilitators, connection with other women veterans, and maintenance of individuality. 

In fact, the social support elements of the current intervention may have directly contributed to the observed improvements in pain severity and interference, the researchers suggest. They also cite another potential mechanism: impacting loneliness. Other studies have found that loneliness is prevalent among rural-dwelling women with chronic illnesses; research in rural settings also suggests that interventions focused on shared interests and common experiences might reduce loneliness. Moreover, reducing loneliness may have an independent benefit: In that research, loneliness was a risk factor for developing the pain, depression, and fatigue symptom cluster. 

The women in the telehealth study often spoke about the emotional benefits and camaraderie of the group sessions. They reported feeling understood. “The most memorable thing was that I just felt good,” one participant said. “…They helped me approach what was going on in my life. …[T]hey never grouped us together. We were all individuals with similar problems.”

Social support might help to buffer stress, which in turn may improve the experience of pain, via its effect on stressor appraisals and coping resources. Thus, their findings pair well, the researchers say, with the creation of the Women Veterans Network (WoVeN), a national peer-facilitated social support intervention aimed at ameliorating loneliness and increasing support among women veterans. Ultimately, they suggest, their findings may lead to help for women veterans living with chronic pain—whether they live in the country or the city.

Women veterans who live in rural areas face multifaceted challenges in managing chronic pain. Some barriers are logistical, including distance from health care facilities and the time required to get there, while others are financial, such as the cost of gas. Researchers from the Veterans Rural Health Resource Center and the Iowa City Veterans Affairs (VA) Health Care System designed a telehealth intervention specifically for rural women. What the study revealed was that social interactions and camaraderie may be just as important in reducing pain as gentle exercise and behavioral changes.

The participants, recruited from a Midwestern VA health care system, were dealing with chronic pain. In baseline measurements, average scores on the Pain, Enjoyment of Life, and General Activity three-item scale (PEG-3) indicated severe pain and functional interference. Notably, the researchers point out, rural women veterans with chronic pain are less likely than urban veterans to receive specialty pain care.

The researchers designed a program of pain self-management options, allowing the participants to sample from a range of empirically supported approaches in one easily accessible format. The program was primarily delivered over video, to support group processes as well as access to video-based components of the intervention (such as yoga lessons) or to display pages from the participant manual for in-session review. The researchers planned it as a women-only space, to provide a “psychologically safe, gender-sensitive, empowering environment.” 

Eight weekly 90-minute sessions featured mindful movement (gentle yoga, graduated walking), peer connection and support, and an introduction to an evidence-based pain or lifestyle self-management topic such as nutrition. The program also included content based on previous work in chronic pain including acceptance and commitment therapy, cognitive behavioral therapy, and dialectical behavior therapy.

Of the 44 participants, 84% completed the intervention. About half of treatment completers (47%) were deemed responders, reporting a ≥ 30% reduction on their PEG-3 total scores. On the Global Impression of Change scale, 87% reported improvement. 

Of the 30 participants who provided follow-up data, 94% were satisfied or very satisfied; no one reported being dissatisfied with the intervention. 

In qualitative interviews, though, the researchers say a clear theme emerged, reflecting the impact and benefit of the balance of three social and psychological components: rapport with facilitators, connection with other women veterans, and maintenance of individuality. 

In fact, the social support elements of the current intervention may have directly contributed to the observed improvements in pain severity and interference, the researchers suggest. They also cite another potential mechanism: impacting loneliness. Other studies have found that loneliness is prevalent among rural-dwelling women with chronic illnesses; research in rural settings also suggests that interventions focused on shared interests and common experiences might reduce loneliness. Moreover, reducing loneliness may have an independent benefit: In that research, loneliness was a risk factor for developing the pain, depression, and fatigue symptom cluster. 

The women in the telehealth study often spoke about the emotional benefits and camaraderie of the group sessions. They reported feeling understood. “The most memorable thing was that I just felt good,” one participant said. “…They helped me approach what was going on in my life. …[T]hey never grouped us together. We were all individuals with similar problems.”

Social support might help to buffer stress, which in turn may improve the experience of pain, via its effect on stressor appraisals and coping resources. Thus, their findings pair well, the researchers say, with the creation of the Women Veterans Network (WoVeN), a national peer-facilitated social support intervention aimed at ameliorating loneliness and increasing support among women veterans. Ultimately, they suggest, their findings may lead to help for women veterans living with chronic pain—whether they live in the country or the city.

Women veterans who live in rural areas face multifaceted challenges in managing chronic pain. Some barriers are logistical, including distance from health care facilities and the time required to get there, while others are financial, such as the cost of gas. Researchers from the Veterans Rural Health Resource Center and the Iowa City Veterans Affairs (VA) Health Care System designed a telehealth intervention specifically for rural women. What the study revealed was that social interactions and camaraderie may be just as important in reducing pain as gentle exercise and behavioral changes.

The participants, recruited from a Midwestern VA health care system, were dealing with chronic pain. In baseline measurements, average scores on the Pain, Enjoyment of Life, and General Activity three-item scale (PEG-3) indicated severe pain and functional interference. Notably, the researchers point out, rural women veterans with chronic pain are less likely than urban veterans to receive specialty pain care.

The researchers designed a program of pain self-management options, allowing the participants to sample from a range of empirically supported approaches in one easily accessible format. The program was primarily delivered over video, to support group processes as well as access to video-based components of the intervention (such as yoga lessons) or to display pages from the participant manual for in-session review. The researchers planned it as a women-only space, to provide a “psychologically safe, gender-sensitive, empowering environment.” 

Eight weekly 90-minute sessions featured mindful movement (gentle yoga, graduated walking), peer connection and support, and an introduction to an evidence-based pain or lifestyle self-management topic such as nutrition. The program also included content based on previous work in chronic pain including acceptance and commitment therapy, cognitive behavioral therapy, and dialectical behavior therapy.

Of the 44 participants, 84% completed the intervention. About half of treatment completers (47%) were deemed responders, reporting a ≥ 30% reduction on their PEG-3 total scores. On the Global Impression of Change scale, 87% reported improvement. 

Of the 30 participants who provided follow-up data, 94% were satisfied or very satisfied; no one reported being dissatisfied with the intervention. 

In qualitative interviews, though, the researchers say a clear theme emerged, reflecting the impact and benefit of the balance of three social and psychological components: rapport with facilitators, connection with other women veterans, and maintenance of individuality. 

In fact, the social support elements of the current intervention may have directly contributed to the observed improvements in pain severity and interference, the researchers suggest. They also cite another potential mechanism: impacting loneliness. Other studies have found that loneliness is prevalent among rural-dwelling women with chronic illnesses; research in rural settings also suggests that interventions focused on shared interests and common experiences might reduce loneliness. Moreover, reducing loneliness may have an independent benefit: In that research, loneliness was a risk factor for developing the pain, depression, and fatigue symptom cluster. 

The women in the telehealth study often spoke about the emotional benefits and camaraderie of the group sessions. They reported feeling understood. “The most memorable thing was that I just felt good,” one participant said. “…They helped me approach what was going on in my life. …[T]hey never grouped us together. We were all individuals with similar problems.”

Social support might help to buffer stress, which in turn may improve the experience of pain, via its effect on stressor appraisals and coping resources. Thus, their findings pair well, the researchers say, with the creation of the Women Veterans Network (WoVeN), a national peer-facilitated social support intervention aimed at ameliorating loneliness and increasing support among women veterans. Ultimately, they suggest, their findings may lead to help for women veterans living with chronic pain—whether they live in the country or the city.

The US Department of Veterans Affairs (VA) has adopted new technology designed to make it easier and faster for veterans to schedule appointments with community care health care practitioners (HCPs).

Through the External Provider Scheduling (EPS) system, VA employees can access the scheduling systems of participating community care HCPs. As of March 2026, 27,000 community care HCPs were participating in EPS across 78 medical specialties.

Without this system, VA employees have to call multiple community care HCPs and relay that information back to veterans before booking an appointment. As a result, a single VA employee could only schedule a handful of community care appointments per day, and it could take days or even weeks to book an appointment for a veteran.

Now, the new system—implemented in all VA facilities starting in late 2025—enables VA employees to schedule as many as 25 appointments daily.

“We are making it easier and more convenient than ever for those who have worn the uniform to choose the care that best fits their lifestyle,” VA Secretary Doug Collins said in a news release.

The VA goal is to sign up thousands of additional community care HCPs in 2026 as part of its continuing efforts to deliver timely, veteran-centered care. There is no cost for institutions to participate in the program.

Select Medical, an outpatient rehabilitation organization with > 1900 centers in 39 states and the District of Columbia, became aware of this opportunity in the first half of 2025: “At that time, we met with key VA stakeholders to learn more about the new program, the challenges it would address, and how it worked to evaluate our ability to participate,” said Chad Smith, president of the company’s outpatient division, headquartered in Mechanicsburg, Pennsylvania.

“We immediately saw the value in what the VA was seeking to accomplish and wanted to be part of providing increased access to exceptional care for our nation’s veterans,” Smith said.

In July 2025, Smith noted, Select Medical piloted the program in 2 states. After successful deployment, the organization broadened its participation to 15 states, offering “seamless access to care” to > 3000 veterans. They receive outpatient rehabilitative care, including physical and occupational therapy.

“The External Provider Scheduling system creates a more streamlined way for veterans and VA administrators to manage the appointment process,” Smith said.

Northwell Health in Lake Success, New York, expressed interest in the program last summer when approached by the VA and “jumped at it,” said Juan Serrano, MBA, MS, vice president of military liaison services at Northwell Health.

The Long Island-based system, which already had a long-standing relationship with the VA, rolled out the program to give veterans the ability to see community care HCPs, Serrano said.

The program started in November, with the first appointment booked in December. From then until the end of April, the program booked 69 appointments for almost 80 veterans, with gastroenterology and otolaryngology representing the highest volume specialties.

Veterans also have gained entry to several other specialty clinics, including imaging services. The program has decreased waiting times for veterans’ appointments and helped them establish rapport with community care HCPs, Serrano said.

“One of the biggest setbacks and difficulties veterans experience is timely access to care outside of the VA,” he said, adding, “as an organization, we made a pledge to create a pathway for veterans to complement the work of the VA and give veterans access to our network.”

The US Department of Veterans Affairs (VA) has adopted new technology designed to make it easier and faster for veterans to schedule appointments with community care health care practitioners (HCPs).

Through the External Provider Scheduling (EPS) system, VA employees can access the scheduling systems of participating community care HCPs. As of March 2026, 27,000 community care HCPs were participating in EPS across 78 medical specialties.

Without this system, VA employees have to call multiple community care HCPs and relay that information back to veterans before booking an appointment. As a result, a single VA employee could only schedule a handful of community care appointments per day, and it could take days or even weeks to book an appointment for a veteran.

Now, the new system—implemented in all VA facilities starting in late 2025—enables VA employees to schedule as many as 25 appointments daily.

“We are making it easier and more convenient than ever for those who have worn the uniform to choose the care that best fits their lifestyle,” VA Secretary Doug Collins said in a news release.

The VA goal is to sign up thousands of additional community care HCPs in 2026 as part of its continuing efforts to deliver timely, veteran-centered care. There is no cost for institutions to participate in the program.

Select Medical, an outpatient rehabilitation organization with > 1900 centers in 39 states and the District of Columbia, became aware of this opportunity in the first half of 2025: “At that time, we met with key VA stakeholders to learn more about the new program, the challenges it would address, and how it worked to evaluate our ability to participate,” said Chad Smith, president of the company’s outpatient division, headquartered in Mechanicsburg, Pennsylvania.

“We immediately saw the value in what the VA was seeking to accomplish and wanted to be part of providing increased access to exceptional care for our nation’s veterans,” Smith said.

In July 2025, Smith noted, Select Medical piloted the program in 2 states. After successful deployment, the organization broadened its participation to 15 states, offering “seamless access to care” to > 3000 veterans. They receive outpatient rehabilitative care, including physical and occupational therapy.

“The External Provider Scheduling system creates a more streamlined way for veterans and VA administrators to manage the appointment process,” Smith said.

Northwell Health in Lake Success, New York, expressed interest in the program last summer when approached by the VA and “jumped at it,” said Juan Serrano, MBA, MS, vice president of military liaison services at Northwell Health.

The Long Island-based system, which already had a long-standing relationship with the VA, rolled out the program to give veterans the ability to see community care HCPs, Serrano said.

The program started in November, with the first appointment booked in December. From then until the end of April, the program booked 69 appointments for almost 80 veterans, with gastroenterology and otolaryngology representing the highest volume specialties.

Veterans also have gained entry to several other specialty clinics, including imaging services. The program has decreased waiting times for veterans’ appointments and helped them establish rapport with community care HCPs, Serrano said.

“One of the biggest setbacks and difficulties veterans experience is timely access to care outside of the VA,” he said, adding, “as an organization, we made a pledge to create a pathway for veterans to complement the work of the VA and give veterans access to our network.”

The US Department of Veterans Affairs (VA) has adopted new technology designed to make it easier and faster for veterans to schedule appointments with community care health care practitioners (HCPs).

Through the External Provider Scheduling (EPS) system, VA employees can access the scheduling systems of participating community care HCPs. As of March 2026, 27,000 community care HCPs were participating in EPS across 78 medical specialties.

Without this system, VA employees have to call multiple community care HCPs and relay that information back to veterans before booking an appointment. As a result, a single VA employee could only schedule a handful of community care appointments per day, and it could take days or even weeks to book an appointment for a veteran.

Now, the new system—implemented in all VA facilities starting in late 2025—enables VA employees to schedule as many as 25 appointments daily.

“We are making it easier and more convenient than ever for those who have worn the uniform to choose the care that best fits their lifestyle,” VA Secretary Doug Collins said in a news release.

The VA goal is to sign up thousands of additional community care HCPs in 2026 as part of its continuing efforts to deliver timely, veteran-centered care. There is no cost for institutions to participate in the program.

Select Medical, an outpatient rehabilitation organization with > 1900 centers in 39 states and the District of Columbia, became aware of this opportunity in the first half of 2025: “At that time, we met with key VA stakeholders to learn more about the new program, the challenges it would address, and how it worked to evaluate our ability to participate,” said Chad Smith, president of the company’s outpatient division, headquartered in Mechanicsburg, Pennsylvania.

“We immediately saw the value in what the VA was seeking to accomplish and wanted to be part of providing increased access to exceptional care for our nation’s veterans,” Smith said.

In July 2025, Smith noted, Select Medical piloted the program in 2 states. After successful deployment, the organization broadened its participation to 15 states, offering “seamless access to care” to > 3000 veterans. They receive outpatient rehabilitative care, including physical and occupational therapy.

“The External Provider Scheduling system creates a more streamlined way for veterans and VA administrators to manage the appointment process,” Smith said.

Northwell Health in Lake Success, New York, expressed interest in the program last summer when approached by the VA and “jumped at it,” said Juan Serrano, MBA, MS, vice president of military liaison services at Northwell Health.

The Long Island-based system, which already had a long-standing relationship with the VA, rolled out the program to give veterans the ability to see community care HCPs, Serrano said.

The program started in November, with the first appointment booked in December. From then until the end of April, the program booked 69 appointments for almost 80 veterans, with gastroenterology and otolaryngology representing the highest volume specialties.

Veterans also have gained entry to several other specialty clinics, including imaging services. The program has decreased waiting times for veterans’ appointments and helped them establish rapport with community care HCPs, Serrano said.

“One of the biggest setbacks and difficulties veterans experience is timely access to care outside of the VA,” he said, adding, “as an organization, we made a pledge to create a pathway for veterans to complement the work of the VA and give veterans access to our network.”

TOPLINE:

Among women aged > 65 years who were at a high risk for cervical cancer and required screening, only 5.2% received appropriate screening. Women with a history of high-grade cervical dysplasia had a greater likelihood of appropriate screening.

METHODOLOGY:

• Researchers conducted a retrospective study to assess the rates of appropriate cervical cancer screening among 1787 women aged 66 years or older (median, 76 years; 96.3% White) who had a Medicare wellness visit or an annual gynecologic visit in a healthcare system in 2022.
• Data on age at the last cervical cancer screening, history of hysterectomy, human papillomavirus (HPV) status, and history of a diagnosis of cervical cancer or cervical dysplasia, high-grade dysplasia, and immune deficiency status were assessed.
• Participants were categorized into 2 groups: those at high risk for cervical cancer (prior high-grade cervical dysplasia or cancer, an immunocompromised status, or lack of two normal cytology results in the past 10 years; n = 250) and those at average risk (having no high-risk features and adequate prior screening or having a prior hysterectomy with no history of high-grade cervical dysplasia; n = 1537).
• The screening cessation criteria were based on adequate prior screening, defined as two prior negative cervical cancer screenings in the past 10 years, the absence of high-grade cervical dysplasia or cervical cancer, and no immune deficiency.

TAKEAWAY:

• Overall, 4.9% of patients had a history of inadequate prior screening; among women at high risk, 5.2% were appropriately screened.
• The odds of continued screening were greater for women with a history of a positive HPV test results (adjusted odds ratio [aOR], 3.4; P = .016), a history of high-grade cervical dysplasia (aOR, 3.8; P = .009), and those without prior hysterectomy (aOR, 2.2; P = .005).
• Among women at high risk for cervical cancer, those with a history of high-grade cervical dysplasia had increased odds of appropriate screening (aOR, 6.7; P = .002), whereas the odds decreased with every 5-year increase in age (aOR, 0.5; P = .031). Women with prior hysterectomy were less likely to be over-screened (aOR, 0.3; P < .001) than those without.
• Among the 79 women who underwent screening, 97.5% had normal cytology results; the remaining women had abnormal cytology results (atypical squamous cells of undetermined significance or atypical squamous cells); all patients with abnormal cytology results met high-risk criteria and were screened appropriately.

IN PRACTICE:

“[The study] findings suggest that most clinicians and patients are aware of recommendations to stop cervical cancer screening after age 65 years. However, there may be a lack of awareness regarding continued screening in high-risk patients or those with inadequate prior screening. The lack of prior screening history and results in the medical record suggests that providers may not understand the importance of these factors to inform cervical cancer screening in older patients,” the authors of the study wrote.

SOURCE:

The study was led by Daniel Rodriguez, BS, Kolschowsky Research and Education Institute, Sarasota Memorial Health Care System, Sarasota, Florida. It was published online on April 23, 2026, in the Journal of Lower Genital Tract Disease.

LIMITATIONS:

Screening history in electronic medical records may be incomplete.

DISCLOSURES:

The Sarasota Memorial Healthcare Foundation provided financial support for this research. The authors declared having no conflicts of interest.

This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

A version of this article first appeared on Medscape.com.

TOPLINE:

Among women aged > 65 years who were at a high risk for cervical cancer and required screening, only 5.2% received appropriate screening. Women with a history of high-grade cervical dysplasia had a greater likelihood of appropriate screening.

METHODOLOGY:

• Researchers conducted a retrospective study to assess the rates of appropriate cervical cancer screening among 1787 women aged 66 years or older (median, 76 years; 96.3% White) who had a Medicare wellness visit or an annual gynecologic visit in a healthcare system in 2022.
• Data on age at the last cervical cancer screening, history of hysterectomy, human papillomavirus (HPV) status, and history of a diagnosis of cervical cancer or cervical dysplasia, high-grade dysplasia, and immune deficiency status were assessed.
• Participants were categorized into 2 groups: those at high risk for cervical cancer (prior high-grade cervical dysplasia or cancer, an immunocompromised status, or lack of two normal cytology results in the past 10 years; n = 250) and those at average risk (having no high-risk features and adequate prior screening or having a prior hysterectomy with no history of high-grade cervical dysplasia; n = 1537).
• The screening cessation criteria were based on adequate prior screening, defined as two prior negative cervical cancer screenings in the past 10 years, the absence of high-grade cervical dysplasia or cervical cancer, and no immune deficiency.

TAKEAWAY:

• Overall, 4.9% of patients had a history of inadequate prior screening; among women at high risk, 5.2% were appropriately screened.
• The odds of continued screening were greater for women with a history of a positive HPV test results (adjusted odds ratio [aOR], 3.4; P = .016), a history of high-grade cervical dysplasia (aOR, 3.8; P = .009), and those without prior hysterectomy (aOR, 2.2; P = .005).
• Among women at high risk for cervical cancer, those with a history of high-grade cervical dysplasia had increased odds of appropriate screening (aOR, 6.7; P = .002), whereas the odds decreased with every 5-year increase in age (aOR, 0.5; P = .031). Women with prior hysterectomy were less likely to be over-screened (aOR, 0.3; P < .001) than those without.
• Among the 79 women who underwent screening, 97.5% had normal cytology results; the remaining women had abnormal cytology results (atypical squamous cells of undetermined significance or atypical squamous cells); all patients with abnormal cytology results met high-risk criteria and were screened appropriately.

IN PRACTICE:

“[The study] findings suggest that most clinicians and patients are aware of recommendations to stop cervical cancer screening after age 65 years. However, there may be a lack of awareness regarding continued screening in high-risk patients or those with inadequate prior screening. The lack of prior screening history and results in the medical record suggests that providers may not understand the importance of these factors to inform cervical cancer screening in older patients,” the authors of the study wrote.

SOURCE:

The study was led by Daniel Rodriguez, BS, Kolschowsky Research and Education Institute, Sarasota Memorial Health Care System, Sarasota, Florida. It was published online on April 23, 2026, in the Journal of Lower Genital Tract Disease.

LIMITATIONS:

Screening history in electronic medical records may be incomplete.

DISCLOSURES:

The Sarasota Memorial Healthcare Foundation provided financial support for this research. The authors declared having no conflicts of interest.

This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

A version of this article first appeared on Medscape.com.

TOPLINE:

Among women aged > 65 years who were at a high risk for cervical cancer and required screening, only 5.2% received appropriate screening. Women with a history of high-grade cervical dysplasia had a greater likelihood of appropriate screening.

METHODOLOGY:

• Researchers conducted a retrospective study to assess the rates of appropriate cervical cancer screening among 1787 women aged 66 years or older (median, 76 years; 96.3% White) who had a Medicare wellness visit or an annual gynecologic visit in a healthcare system in 2022.
• Data on age at the last cervical cancer screening, history of hysterectomy, human papillomavirus (HPV) status, and history of a diagnosis of cervical cancer or cervical dysplasia, high-grade dysplasia, and immune deficiency status were assessed.
• Participants were categorized into 2 groups: those at high risk for cervical cancer (prior high-grade cervical dysplasia or cancer, an immunocompromised status, or lack of two normal cytology results in the past 10 years; n = 250) and those at average risk (having no high-risk features and adequate prior screening or having a prior hysterectomy with no history of high-grade cervical dysplasia; n = 1537).
• The screening cessation criteria were based on adequate prior screening, defined as two prior negative cervical cancer screenings in the past 10 years, the absence of high-grade cervical dysplasia or cervical cancer, and no immune deficiency.

TAKEAWAY:

• Overall, 4.9% of patients had a history of inadequate prior screening; among women at high risk, 5.2% were appropriately screened.
• The odds of continued screening were greater for women with a history of a positive HPV test results (adjusted odds ratio [aOR], 3.4; P = .016), a history of high-grade cervical dysplasia (aOR, 3.8; P = .009), and those without prior hysterectomy (aOR, 2.2; P = .005).
• Among women at high risk for cervical cancer, those with a history of high-grade cervical dysplasia had increased odds of appropriate screening (aOR, 6.7; P = .002), whereas the odds decreased with every 5-year increase in age (aOR, 0.5; P = .031). Women with prior hysterectomy were less likely to be over-screened (aOR, 0.3; P < .001) than those without.
• Among the 79 women who underwent screening, 97.5% had normal cytology results; the remaining women had abnormal cytology results (atypical squamous cells of undetermined significance or atypical squamous cells); all patients with abnormal cytology results met high-risk criteria and were screened appropriately.

IN PRACTICE:

“[The study] findings suggest that most clinicians and patients are aware of recommendations to stop cervical cancer screening after age 65 years. However, there may be a lack of awareness regarding continued screening in high-risk patients or those with inadequate prior screening. The lack of prior screening history and results in the medical record suggests that providers may not understand the importance of these factors to inform cervical cancer screening in older patients,” the authors of the study wrote.

SOURCE:

The study was led by Daniel Rodriguez, BS, Kolschowsky Research and Education Institute, Sarasota Memorial Health Care System, Sarasota, Florida. It was published online on April 23, 2026, in the Journal of Lower Genital Tract Disease.

LIMITATIONS:

Screening history in electronic medical records may be incomplete.

DISCLOSURES:

The Sarasota Memorial Healthcare Foundation provided financial support for this research. The authors declared having no conflicts of interest.

This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

A version of this article first appeared on Medscape.com.

Women who undergo surgery for breast cancer often hear that they should take it easy with exercise during recovery. But new research looking at intense strength training puts that advice into question.

The study, of nearly 200 women who’d undergone lumpectomy or mastectomy, found that a 3-month weight-training program helped patients make substantial gains in strength, mobility, balance, and body composition.

And while previous studies have examined resistance exercise during breast cancer surgery recovery, this program pumped up the intensity: Most women progressed to deadlifting 100 to 200 pounds, even though few had ever performed strength training before.

“Most of these patients can do a lot more than we think,” said principal investigator Colin Champ, MD, director of the Exercise Oncology and Resiliency Center at Allegheny Health Network in Pittsburgh.

The findings were presented at The American Society of Breast Surgeons (ASBrS) Annual Meeting, held in Seattle from April 29 to May 3.

Pumping Up the Intensity

For the analysis, Champ and his colleagues pooled the results of 3 small prospective studies of their strength conditioning program, including one that previously reported no worsening in patients’ lymphedema, and instead, showed signs of improvement.

The researchers evaluated program participants’ physical and functional gains and whether any of those parameters differed by the extent of their breast cancer surgery.

In total, there were 197 participants, including 85 who’d undergone mastectomies and 112 who’d had lumpectomies; 26 patients also had axillary lymph node dissection.

All of the women attended the same 3-month supervised strength-training program, starting at various points in their recovery process. Nearly half started at 3 months postdiagnosis.

According to Champ, the program addresses a full range of motion, with the exercise intensity building over a short period — similar to what professional athletes do in early training. The specific exercises include split squats, dumbbell presses, and dumbbell rows, done 3 days per week, for about 45-60 minutes.

Most participants, Champ said, start with deadlifting around 70 pounds (lifting weight from the floor to hip level). “If you can carry groceries, you can deadlift 60 or 70 pounds,” he noted.

Each month, the weight and sets increase, while the repetitions decrease.

“We just had a woman in her 70s who deadlifted about 200 pounds” as the program progressed, Champ said.

Benefits Regardless of Surgery Type

Women in the current analysis underwent baseline and post-program testing of body composition and functional parameters, including strength, mobility, and balance. Mastectomy patients (median age, 51 years) were younger than lumpectomy patients (median age, 59 years). They were also more likely to have had chemotherapy (45% vs 27%).

Overall, Champ’s team found that both surgery groups showed statistically significant improvements in muscle and body fat percentages over the course of the program, with muscle mass increasing by 1 percentage point on average and body fat declining by 1.5 percentage points.

Similarly, functional movement scores, grip strength, loads lifted, and balance skills also improved, with comparable benefits regardless of surgery type or whether lymph node dissection was performed.

By the end of the program’s third week, Champ said, most women could deadlift 100-pound weights. And by the 3-month mark, many were able to lift 200-pound loads.

Champ called the results empowering, and he hopes they help reframe the traditional mindset that intense strength training is too heavy a lift after breast cancer surgery.

A surgical oncologist who was not involved in the study agreed.

“This gives us something concrete to say to patients,” said Tina Hieken, MD, of the Mayo Clinic in Rochester, Minnesota. “We have more data to say it’s safe for you to exercise.’’

Hieken, who chaired the meeting’s scientific program committee, also noted that the findings pertain to women of all baseline fitness levels.

For her part, Hieken already encourages patients to walk for exercise and spend time outdoors — in part for the mental well-being benefits.

With patients facing so much uncertainty after a cancer diagnosis, she said, “this is something an individual can take control of.”

Champ and Hieken had no disclosures.

A version of this article first appeared on Medscape.com.

Women who undergo surgery for breast cancer often hear that they should take it easy with exercise during recovery. But new research looking at intense strength training puts that advice into question.

The study, of nearly 200 women who’d undergone lumpectomy or mastectomy, found that a 3-month weight-training program helped patients make substantial gains in strength, mobility, balance, and body composition.

And while previous studies have examined resistance exercise during breast cancer surgery recovery, this program pumped up the intensity: Most women progressed to deadlifting 100 to 200 pounds, even though few had ever performed strength training before.

“Most of these patients can do a lot more than we think,” said principal investigator Colin Champ, MD, director of the Exercise Oncology and Resiliency Center at Allegheny Health Network in Pittsburgh.

The findings were presented at The American Society of Breast Surgeons (ASBrS) Annual Meeting, held in Seattle from April 29 to May 3.

Pumping Up the Intensity

For the analysis, Champ and his colleagues pooled the results of 3 small prospective studies of their strength conditioning program, including one that previously reported no worsening in patients’ lymphedema, and instead, showed signs of improvement.

The researchers evaluated program participants’ physical and functional gains and whether any of those parameters differed by the extent of their breast cancer surgery.

In total, there were 197 participants, including 85 who’d undergone mastectomies and 112 who’d had lumpectomies; 26 patients also had axillary lymph node dissection.

All of the women attended the same 3-month supervised strength-training program, starting at various points in their recovery process. Nearly half started at 3 months postdiagnosis.

According to Champ, the program addresses a full range of motion, with the exercise intensity building over a short period — similar to what professional athletes do in early training. The specific exercises include split squats, dumbbell presses, and dumbbell rows, done 3 days per week, for about 45-60 minutes.

Most participants, Champ said, start with deadlifting around 70 pounds (lifting weight from the floor to hip level). “If you can carry groceries, you can deadlift 60 or 70 pounds,” he noted.

Each month, the weight and sets increase, while the repetitions decrease.

“We just had a woman in her 70s who deadlifted about 200 pounds” as the program progressed, Champ said.

Benefits Regardless of Surgery Type

Women in the current analysis underwent baseline and post-program testing of body composition and functional parameters, including strength, mobility, and balance. Mastectomy patients (median age, 51 years) were younger than lumpectomy patients (median age, 59 years). They were also more likely to have had chemotherapy (45% vs 27%).

Overall, Champ’s team found that both surgery groups showed statistically significant improvements in muscle and body fat percentages over the course of the program, with muscle mass increasing by 1 percentage point on average and body fat declining by 1.5 percentage points.

Similarly, functional movement scores, grip strength, loads lifted, and balance skills also improved, with comparable benefits regardless of surgery type or whether lymph node dissection was performed.

By the end of the program’s third week, Champ said, most women could deadlift 100-pound weights. And by the 3-month mark, many were able to lift 200-pound loads.

Champ called the results empowering, and he hopes they help reframe the traditional mindset that intense strength training is too heavy a lift after breast cancer surgery.

A surgical oncologist who was not involved in the study agreed.

“This gives us something concrete to say to patients,” said Tina Hieken, MD, of the Mayo Clinic in Rochester, Minnesota. “We have more data to say it’s safe for you to exercise.’’

Hieken, who chaired the meeting’s scientific program committee, also noted that the findings pertain to women of all baseline fitness levels.

For her part, Hieken already encourages patients to walk for exercise and spend time outdoors — in part for the mental well-being benefits.

With patients facing so much uncertainty after a cancer diagnosis, she said, “this is something an individual can take control of.”

Champ and Hieken had no disclosures.

A version of this article first appeared on Medscape.com.

Women who undergo surgery for breast cancer often hear that they should take it easy with exercise during recovery. But new research looking at intense strength training puts that advice into question.

The study, of nearly 200 women who’d undergone lumpectomy or mastectomy, found that a 3-month weight-training program helped patients make substantial gains in strength, mobility, balance, and body composition.

And while previous studies have examined resistance exercise during breast cancer surgery recovery, this program pumped up the intensity: Most women progressed to deadlifting 100 to 200 pounds, even though few had ever performed strength training before.

“Most of these patients can do a lot more than we think,” said principal investigator Colin Champ, MD, director of the Exercise Oncology and Resiliency Center at Allegheny Health Network in Pittsburgh.

The findings were presented at The American Society of Breast Surgeons (ASBrS) Annual Meeting, held in Seattle from April 29 to May 3.

Pumping Up the Intensity

For the analysis, Champ and his colleagues pooled the results of 3 small prospective studies of their strength conditioning program, including one that previously reported no worsening in patients’ lymphedema, and instead, showed signs of improvement.

The researchers evaluated program participants’ physical and functional gains and whether any of those parameters differed by the extent of their breast cancer surgery.

In total, there were 197 participants, including 85 who’d undergone mastectomies and 112 who’d had lumpectomies; 26 patients also had axillary lymph node dissection.

All of the women attended the same 3-month supervised strength-training program, starting at various points in their recovery process. Nearly half started at 3 months postdiagnosis.

According to Champ, the program addresses a full range of motion, with the exercise intensity building over a short period — similar to what professional athletes do in early training. The specific exercises include split squats, dumbbell presses, and dumbbell rows, done 3 days per week, for about 45-60 minutes.

Most participants, Champ said, start with deadlifting around 70 pounds (lifting weight from the floor to hip level). “If you can carry groceries, you can deadlift 60 or 70 pounds,” he noted.

Each month, the weight and sets increase, while the repetitions decrease.

“We just had a woman in her 70s who deadlifted about 200 pounds” as the program progressed, Champ said.

Benefits Regardless of Surgery Type

Women in the current analysis underwent baseline and post-program testing of body composition and functional parameters, including strength, mobility, and balance. Mastectomy patients (median age, 51 years) were younger than lumpectomy patients (median age, 59 years). They were also more likely to have had chemotherapy (45% vs 27%).

Overall, Champ’s team found that both surgery groups showed statistically significant improvements in muscle and body fat percentages over the course of the program, with muscle mass increasing by 1 percentage point on average and body fat declining by 1.5 percentage points.

Similarly, functional movement scores, grip strength, loads lifted, and balance skills also improved, with comparable benefits regardless of surgery type or whether lymph node dissection was performed.

By the end of the program’s third week, Champ said, most women could deadlift 100-pound weights. And by the 3-month mark, many were able to lift 200-pound loads.

Champ called the results empowering, and he hopes they help reframe the traditional mindset that intense strength training is too heavy a lift after breast cancer surgery.

A surgical oncologist who was not involved in the study agreed.

“This gives us something concrete to say to patients,” said Tina Hieken, MD, of the Mayo Clinic in Rochester, Minnesota. “We have more data to say it’s safe for you to exercise.’’

Hieken, who chaired the meeting’s scientific program committee, also noted that the findings pertain to women of all baseline fitness levels.

For her part, Hieken already encourages patients to walk for exercise and spend time outdoors — in part for the mental well-being benefits.

With patients facing so much uncertainty after a cancer diagnosis, she said, “this is something an individual can take control of.”

Champ and Hieken had no disclosures.

A version of this article first appeared on Medscape.com.

Dual checkpoint blockade allowed 70.6% of patients with microsatellite instability-high (MSI-H) resectable gastric or gastroesophageal junction adenocarcinoma (G/GEJAC) to avoid surgery in a small cohort of the INFINITY study.

MSI-H tumors account for roughly 10% of early G/GEJACs. They respond well to immunotherapy, with high rates of pathologic complete responses. The Italian INFINITY trial set out to test whether some patients with these tumors might not need gastrectomy.

The trial treated MSI-H patients with durvalumab 1500 mg once a month for 3 months along with 1 300-mg dose of the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) blocker tremelimumab on day 1. The 18 patients in cohort 1 proceeded to surgery, with a 60% pathologic complete response rate. An additional 18 patients in cohort 2 were the subject of a presentation at the American Association for Cancer Research (AACR) Annual Meeting 2026. These patients were assessed for clinical complete response; if present, they went on to surveillance; if not, they had surgery.

To qualify for a clinical complete response and surveillance, patients were required to have negative findings on CT and PET scans; tumor-informed circulating tumor DNA (ctDNA); and upper endoscopy with ultrasound, including bite-on-bite biopsies and nodal sampling. Surveillance afterward included CT, endoscopy with biopsies, and ctDNA every 12 weeks for up to 2 years.

Among 17 evaluable patients, 1 withdrew consent during immunotherapy, 13 (76%) had a clinical complete response and started surveillance, and the other 4 went to surgery. One patient in the surveillance group had a local regrowth after 4 months, underwent salvage surgery, and remained disease-free. At a median follow-up of 27.1 months, there were no additional progression events.

Overall, 12 of the 17 patients (70.6%) were gastrectomy-free at 2 years without additional treatment. Progression-free survival was 94.1%, and all patients were alive.

“The results are very encouraging,” lead investigator Alberto Leone, MD, said while presenting the results at the AACR annual meeting.

“Nonoperative management could be a safe and effective strategy for patients achieving a clinical complete response after only 3 months of dual immunotherapy,” said Leone, who is a gastrointestinal medical oncologist at the Istituto Nazionale dei Tumori, Milan, Italy. “However, the optimal strategy needs to be established in larger randomized trials.”

Study discussant Yelena Janjagian, MD, gastrointestinal medical oncologist at Memorial Sloan Kettering Cancer Center in New York City, said the findings were important, particularly given that 70.6% of patients avoided a potentially life-altering gastrectomy.

In addition to surgery, the study also calls into question the need for chemotherapy, long the backbone of management alongside surgery, she said. To replace it, however, “it appears that dual checkpoint blockade will be required for a chemotherapy-free approach to achieve organ preservation.”

“Anti-PD-1 alone is not sufficient; we need CTLA-4 to expand and reactivate tumor-specific immunity,” Janjagian continued.

Ultimately, she expects immunotherapy to shift management of MSI-H cancers away from surgery, although some patients will still likely need an operation.

In addition to being MSI-H, patients in the study were mismatch repair deficient and Epstein-Barr virus-negative with T2/T3 tumors; T4 tumors were excluded.

Tumor-agnostic plasma ctDNA was positive at baseline in 13 patients and cleared in 11 after treatment. Higher baseline plasma ctDNA trended toward a lower likelihood of reaching a clinical complete response. Specificity was 100%, so when positive, the test was “very highly informative,” Leone said.

Three patients had grade 3 adverse events (hyperthyroidism, increased gamma-glutamyl transferase, and colitis) that resolved with steroids. There were no grade 4 events, treatment discontinuation, or deaths.

The work was funded by the GONO Foundation and AstraZeneca, the maker of durvalumab and tremelimumab. Leone reported having no disclosures. Janjagian reported having extensive industry ties, including travel funding, consulting fees, and research support from AstraZeneca.

M. Alexander Otto is a physician assistant with a master’s degree in medical science and a journalism degree from Newhouse. He is an award-winning medical journalist who worked for several major news outlets before joining Medscape. Alex is also an MIT Knight Science Journalism fellow. Email: [email protected] 

A version of this article first appeared on Medscape.com.

Dual checkpoint blockade allowed 70.6% of patients with microsatellite instability-high (MSI-H) resectable gastric or gastroesophageal junction adenocarcinoma (G/GEJAC) to avoid surgery in a small cohort of the INFINITY study.

MSI-H tumors account for roughly 10% of early G/GEJACs. They respond well to immunotherapy, with high rates of pathologic complete responses. The Italian INFINITY trial set out to test whether some patients with these tumors might not need gastrectomy.

The trial treated MSI-H patients with durvalumab 1500 mg once a month for 3 months along with 1 300-mg dose of the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) blocker tremelimumab on day 1. The 18 patients in cohort 1 proceeded to surgery, with a 60% pathologic complete response rate. An additional 18 patients in cohort 2 were the subject of a presentation at the American Association for Cancer Research (AACR) Annual Meeting 2026. These patients were assessed for clinical complete response; if present, they went on to surveillance; if not, they had surgery.

To qualify for a clinical complete response and surveillance, patients were required to have negative findings on CT and PET scans; tumor-informed circulating tumor DNA (ctDNA); and upper endoscopy with ultrasound, including bite-on-bite biopsies and nodal sampling. Surveillance afterward included CT, endoscopy with biopsies, and ctDNA every 12 weeks for up to 2 years.

Among 17 evaluable patients, 1 withdrew consent during immunotherapy, 13 (76%) had a clinical complete response and started surveillance, and the other 4 went to surgery. One patient in the surveillance group had a local regrowth after 4 months, underwent salvage surgery, and remained disease-free. At a median follow-up of 27.1 months, there were no additional progression events.

Overall, 12 of the 17 patients (70.6%) were gastrectomy-free at 2 years without additional treatment. Progression-free survival was 94.1%, and all patients were alive.

“The results are very encouraging,” lead investigator Alberto Leone, MD, said while presenting the results at the AACR annual meeting.

“Nonoperative management could be a safe and effective strategy for patients achieving a clinical complete response after only 3 months of dual immunotherapy,” said Leone, who is a gastrointestinal medical oncologist at the Istituto Nazionale dei Tumori, Milan, Italy. “However, the optimal strategy needs to be established in larger randomized trials.”

Study discussant Yelena Janjagian, MD, gastrointestinal medical oncologist at Memorial Sloan Kettering Cancer Center in New York City, said the findings were important, particularly given that 70.6% of patients avoided a potentially life-altering gastrectomy.

In addition to surgery, the study also calls into question the need for chemotherapy, long the backbone of management alongside surgery, she said. To replace it, however, “it appears that dual checkpoint blockade will be required for a chemotherapy-free approach to achieve organ preservation.”

“Anti-PD-1 alone is not sufficient; we need CTLA-4 to expand and reactivate tumor-specific immunity,” Janjagian continued.

Ultimately, she expects immunotherapy to shift management of MSI-H cancers away from surgery, although some patients will still likely need an operation.

In addition to being MSI-H, patients in the study were mismatch repair deficient and Epstein-Barr virus-negative with T2/T3 tumors; T4 tumors were excluded.

Tumor-agnostic plasma ctDNA was positive at baseline in 13 patients and cleared in 11 after treatment. Higher baseline plasma ctDNA trended toward a lower likelihood of reaching a clinical complete response. Specificity was 100%, so when positive, the test was “very highly informative,” Leone said.

Three patients had grade 3 adverse events (hyperthyroidism, increased gamma-glutamyl transferase, and colitis) that resolved with steroids. There were no grade 4 events, treatment discontinuation, or deaths.

The work was funded by the GONO Foundation and AstraZeneca, the maker of durvalumab and tremelimumab. Leone reported having no disclosures. Janjagian reported having extensive industry ties, including travel funding, consulting fees, and research support from AstraZeneca.

M. Alexander Otto is a physician assistant with a master’s degree in medical science and a journalism degree from Newhouse. He is an award-winning medical journalist who worked for several major news outlets before joining Medscape. Alex is also an MIT Knight Science Journalism fellow. Email: [email protected] 

A version of this article first appeared on Medscape.com.

Dual checkpoint blockade allowed 70.6% of patients with microsatellite instability-high (MSI-H) resectable gastric or gastroesophageal junction adenocarcinoma (G/GEJAC) to avoid surgery in a small cohort of the INFINITY study.

MSI-H tumors account for roughly 10% of early G/GEJACs. They respond well to immunotherapy, with high rates of pathologic complete responses. The Italian INFINITY trial set out to test whether some patients with these tumors might not need gastrectomy.

The trial treated MSI-H patients with durvalumab 1500 mg once a month for 3 months along with 1 300-mg dose of the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) blocker tremelimumab on day 1. The 18 patients in cohort 1 proceeded to surgery, with a 60% pathologic complete response rate. An additional 18 patients in cohort 2 were the subject of a presentation at the American Association for Cancer Research (AACR) Annual Meeting 2026. These patients were assessed for clinical complete response; if present, they went on to surveillance; if not, they had surgery.

To qualify for a clinical complete response and surveillance, patients were required to have negative findings on CT and PET scans; tumor-informed circulating tumor DNA (ctDNA); and upper endoscopy with ultrasound, including bite-on-bite biopsies and nodal sampling. Surveillance afterward included CT, endoscopy with biopsies, and ctDNA every 12 weeks for up to 2 years.

Among 17 evaluable patients, 1 withdrew consent during immunotherapy, 13 (76%) had a clinical complete response and started surveillance, and the other 4 went to surgery. One patient in the surveillance group had a local regrowth after 4 months, underwent salvage surgery, and remained disease-free. At a median follow-up of 27.1 months, there were no additional progression events.

Overall, 12 of the 17 patients (70.6%) were gastrectomy-free at 2 years without additional treatment. Progression-free survival was 94.1%, and all patients were alive.

“The results are very encouraging,” lead investigator Alberto Leone, MD, said while presenting the results at the AACR annual meeting.

“Nonoperative management could be a safe and effective strategy for patients achieving a clinical complete response after only 3 months of dual immunotherapy,” said Leone, who is a gastrointestinal medical oncologist at the Istituto Nazionale dei Tumori, Milan, Italy. “However, the optimal strategy needs to be established in larger randomized trials.”

Study discussant Yelena Janjagian, MD, gastrointestinal medical oncologist at Memorial Sloan Kettering Cancer Center in New York City, said the findings were important, particularly given that 70.6% of patients avoided a potentially life-altering gastrectomy.

In addition to surgery, the study also calls into question the need for chemotherapy, long the backbone of management alongside surgery, she said. To replace it, however, “it appears that dual checkpoint blockade will be required for a chemotherapy-free approach to achieve organ preservation.”

“Anti-PD-1 alone is not sufficient; we need CTLA-4 to expand and reactivate tumor-specific immunity,” Janjagian continued.

Ultimately, she expects immunotherapy to shift management of MSI-H cancers away from surgery, although some patients will still likely need an operation.

In addition to being MSI-H, patients in the study were mismatch repair deficient and Epstein-Barr virus-negative with T2/T3 tumors; T4 tumors were excluded.

Tumor-agnostic plasma ctDNA was positive at baseline in 13 patients and cleared in 11 after treatment. Higher baseline plasma ctDNA trended toward a lower likelihood of reaching a clinical complete response. Specificity was 100%, so when positive, the test was “very highly informative,” Leone said.

Three patients had grade 3 adverse events (hyperthyroidism, increased gamma-glutamyl transferase, and colitis) that resolved with steroids. There were no grade 4 events, treatment discontinuation, or deaths.

The work was funded by the GONO Foundation and AstraZeneca, the maker of durvalumab and tremelimumab. Leone reported having no disclosures. Janjagian reported having extensive industry ties, including travel funding, consulting fees, and research support from AstraZeneca.

M. Alexander Otto is a physician assistant with a master’s degree in medical science and a journalism degree from Newhouse. He is an award-winning medical journalist who worked for several major news outlets before joining Medscape. Alex is also an MIT Knight Science Journalism fellow. Email: [email protected] 

A version of this article first appeared on Medscape.com.

A personalized messenger RNA (mRNA) vaccine for pancreatic cancer continues to show promise for improving patient survival, according to 6-year follow-up results of a phase 1 clinical study.

Among the 8 out of 16 patients in the study who initially experienced an immune response to the vaccine, seven (87.5%) were still alive at follow-up, lead investigator Vinod P. Balachandran, MD, reported at the American Association for Cancer Research (AACR) Annual Meeting 2026.

Of the eight patients who did not respond, two (25%) were still alive, with a median survival time of 3.4 years. “This suggests that personalized vaccines can stimulate the immune system in some pancreatic cancer patients, and that these patients continue to do well for several years after vaccination,” said Balachandran, director of the Olayan Center for Cancer Vaccines at Memorial Sloan Kettering Cancer Center in New York City.

The findings suggest that this vaccine has the potential to improve outcomes in patients with pancreatic cancer, which is one of the deadliest cancers, he said.

The 5-year survival rate for pancreatic cancer is currently 13%, according to the American Cancer Society’s Cancer Statistics 2026 report.

Initial results of the trial evaluating the individualized neoantigen vaccine — autogene cevumeran, which is being developed by BioNTech and Genentech — were published in Nature in February 2025.

After pancreatic cancer surgery and chemo-immunotherapy, patients with pancreatic ductal adenocarcinoma (PDAC) received a vaccine personalized to each patient based on unique changes in their tumor DNA.

The eight patients with vaccine-induced T cells had prolonged recurrence-free survival (RFS; median not reached), whereas nonresponders had a median RFS of 13.4 months, the authors had reported in the Nature paper.

This correlation was not confounded by other factors, including those associated with the patient, tumor, treatment, and host immune fitness, Balachandran noted.

In the responders, the T-cell clones had “high magnitude and exceptional longevity,” with an average estimated lifespan of 7.7 years, he said.

A fundamental challenge in developing cancer vaccines has been generating durable functional T cells specific for tumor antigens, and these findings suggest that mRNA-lipoplex vaccines against somatic mutation-derived neoantigens like autogene cevumeran may help overcome this challenge in pancreatic cancer, he and his colleagues concluded in the Nature paper.

The latest findings presented at the AACR annual meeting further underscore the potential of this approach.

At the 6-year follow-up, median RFS was “still not reached” in the vaccine responders vs 1.1 year in the nonresponders, he noted.

“This translates to a difference in overall survival,” he said. “Seven of eight [responders to the vaccine] are still alive 4.5-6 years after surgery.”

And of the 2 of 8 nonresponders still alive, one appears to be mounting a subclinical vaccine-induced T-cell response, he added, noting that this “suggests that inducible vaccine immunity may also impact survival in PDAC.”

“The implication here, we believe, is that even if a cancer has very mutational by-products [like PDAC], these mutational by-products can empower potent and composite immunity,” he said. “This is important because it could potentially expand vaccine eligibility to many cancers.”

Currently, there are about 50 neoantigen vaccine trials in solid tumors ongoing worldwide, he noted.

Memorial Sloan Kettering reports that Genentech and BioNTech are now testing autogene cevumeran in a larger patient population at numerous sites worldwide.

Balachandran reported receiving research support from Genentech, Merck Sharp & Dohme, and AbbVie.

Sharon Worcester, MA, is an award-winning medical journalist based in Birmingham, Alabama, writing for Medscape, MDedge, and other affiliate sites. She currently covers oncology, but she has also written on a variety of other medical specialties and healthcare topics. She can be reached at [email protected] or on X: @SW_MedReporter.

A version of this article first appeared on Medscape.com.

A personalized messenger RNA (mRNA) vaccine for pancreatic cancer continues to show promise for improving patient survival, according to 6-year follow-up results of a phase 1 clinical study.

Among the 8 out of 16 patients in the study who initially experienced an immune response to the vaccine, seven (87.5%) were still alive at follow-up, lead investigator Vinod P. Balachandran, MD, reported at the American Association for Cancer Research (AACR) Annual Meeting 2026.

Of the eight patients who did not respond, two (25%) were still alive, with a median survival time of 3.4 years. “This suggests that personalized vaccines can stimulate the immune system in some pancreatic cancer patients, and that these patients continue to do well for several years after vaccination,” said Balachandran, director of the Olayan Center for Cancer Vaccines at Memorial Sloan Kettering Cancer Center in New York City.

The findings suggest that this vaccine has the potential to improve outcomes in patients with pancreatic cancer, which is one of the deadliest cancers, he said.

The 5-year survival rate for pancreatic cancer is currently 13%, according to the American Cancer Society’s Cancer Statistics 2026 report.

Initial results of the trial evaluating the individualized neoantigen vaccine — autogene cevumeran, which is being developed by BioNTech and Genentech — were published in Nature in February 2025.

After pancreatic cancer surgery and chemo-immunotherapy, patients with pancreatic ductal adenocarcinoma (PDAC) received a vaccine personalized to each patient based on unique changes in their tumor DNA.

The eight patients with vaccine-induced T cells had prolonged recurrence-free survival (RFS; median not reached), whereas nonresponders had a median RFS of 13.4 months, the authors had reported in the Nature paper.

This correlation was not confounded by other factors, including those associated with the patient, tumor, treatment, and host immune fitness, Balachandran noted.

In the responders, the T-cell clones had “high magnitude and exceptional longevity,” with an average estimated lifespan of 7.7 years, he said.

A fundamental challenge in developing cancer vaccines has been generating durable functional T cells specific for tumor antigens, and these findings suggest that mRNA-lipoplex vaccines against somatic mutation-derived neoantigens like autogene cevumeran may help overcome this challenge in pancreatic cancer, he and his colleagues concluded in the Nature paper.

The latest findings presented at the AACR annual meeting further underscore the potential of this approach.

At the 6-year follow-up, median RFS was “still not reached” in the vaccine responders vs 1.1 year in the nonresponders, he noted.

“This translates to a difference in overall survival,” he said. “Seven of eight [responders to the vaccine] are still alive 4.5-6 years after surgery.”

And of the 2 of 8 nonresponders still alive, one appears to be mounting a subclinical vaccine-induced T-cell response, he added, noting that this “suggests that inducible vaccine immunity may also impact survival in PDAC.”

“The implication here, we believe, is that even if a cancer has very mutational by-products [like PDAC], these mutational by-products can empower potent and composite immunity,” he said. “This is important because it could potentially expand vaccine eligibility to many cancers.”

Currently, there are about 50 neoantigen vaccine trials in solid tumors ongoing worldwide, he noted.

Memorial Sloan Kettering reports that Genentech and BioNTech are now testing autogene cevumeran in a larger patient population at numerous sites worldwide.

Balachandran reported receiving research support from Genentech, Merck Sharp & Dohme, and AbbVie.

Sharon Worcester, MA, is an award-winning medical journalist based in Birmingham, Alabama, writing for Medscape, MDedge, and other affiliate sites. She currently covers oncology, but she has also written on a variety of other medical specialties and healthcare topics. She can be reached at [email protected] or on X: @SW_MedReporter.

A version of this article first appeared on Medscape.com.

A personalized messenger RNA (mRNA) vaccine for pancreatic cancer continues to show promise for improving patient survival, according to 6-year follow-up results of a phase 1 clinical study.

Among the 8 out of 16 patients in the study who initially experienced an immune response to the vaccine, seven (87.5%) were still alive at follow-up, lead investigator Vinod P. Balachandran, MD, reported at the American Association for Cancer Research (AACR) Annual Meeting 2026.

Of the eight patients who did not respond, two (25%) were still alive, with a median survival time of 3.4 years. “This suggests that personalized vaccines can stimulate the immune system in some pancreatic cancer patients, and that these patients continue to do well for several years after vaccination,” said Balachandran, director of the Olayan Center for Cancer Vaccines at Memorial Sloan Kettering Cancer Center in New York City.

The findings suggest that this vaccine has the potential to improve outcomes in patients with pancreatic cancer, which is one of the deadliest cancers, he said.

The 5-year survival rate for pancreatic cancer is currently 13%, according to the American Cancer Society’s Cancer Statistics 2026 report.

Initial results of the trial evaluating the individualized neoantigen vaccine — autogene cevumeran, which is being developed by BioNTech and Genentech — were published in Nature in February 2025.

After pancreatic cancer surgery and chemo-immunotherapy, patients with pancreatic ductal adenocarcinoma (PDAC) received a vaccine personalized to each patient based on unique changes in their tumor DNA.

The eight patients with vaccine-induced T cells had prolonged recurrence-free survival (RFS; median not reached), whereas nonresponders had a median RFS of 13.4 months, the authors had reported in the Nature paper.

This correlation was not confounded by other factors, including those associated with the patient, tumor, treatment, and host immune fitness, Balachandran noted.

In the responders, the T-cell clones had “high magnitude and exceptional longevity,” with an average estimated lifespan of 7.7 years, he said.

A fundamental challenge in developing cancer vaccines has been generating durable functional T cells specific for tumor antigens, and these findings suggest that mRNA-lipoplex vaccines against somatic mutation-derived neoantigens like autogene cevumeran may help overcome this challenge in pancreatic cancer, he and his colleagues concluded in the Nature paper.

The latest findings presented at the AACR annual meeting further underscore the potential of this approach.

At the 6-year follow-up, median RFS was “still not reached” in the vaccine responders vs 1.1 year in the nonresponders, he noted.

“This translates to a difference in overall survival,” he said. “Seven of eight [responders to the vaccine] are still alive 4.5-6 years after surgery.”

And of the 2 of 8 nonresponders still alive, one appears to be mounting a subclinical vaccine-induced T-cell response, he added, noting that this “suggests that inducible vaccine immunity may also impact survival in PDAC.”

“The implication here, we believe, is that even if a cancer has very mutational by-products [like PDAC], these mutational by-products can empower potent and composite immunity,” he said. “This is important because it could potentially expand vaccine eligibility to many cancers.”

Currently, there are about 50 neoantigen vaccine trials in solid tumors ongoing worldwide, he noted.

Memorial Sloan Kettering reports that Genentech and BioNTech are now testing autogene cevumeran in a larger patient population at numerous sites worldwide.

Balachandran reported receiving research support from Genentech, Merck Sharp & Dohme, and AbbVie.

Sharon Worcester, MA, is an award-winning medical journalist based in Birmingham, Alabama, writing for Medscape, MDedge, and other affiliate sites. She currently covers oncology, but she has also written on a variety of other medical specialties and healthcare topics. She can be reached at [email protected] or on X: @SW_MedReporter.

A version of this article first appeared on Medscape.com.

TOPLINE:

A large cohort study found that the use of GLP-1 receptor agonists (GLP-1 RAs) over 3 years was associated with a modestly increased risk for nonarteritic anterior ischemic optic neuropathy (NAION) compared with the use of SGLT2 inhibitors in veterans with type 2 diabetes (T2D).

METHODOLOGY:

• Pharmacovigilance reports and emerging, but inconsistent, population-based studies suggest that the use of GLP-1 RAs may be linked to ocular adverse events, including a possible increased risk for NAION; however, it remains unclear whether the association is specific to NAION as compared with other optic disorders.
• Researchers conducted a target trial emulation study using nationwide electronic health records from the US Department of Veterans Affairs to compare the 3-year risk for NAION among veterans with T2D who initiated GLP-1 RAs vs SGLT2 inhibitors.
• The study included 588,168 veterans with T2D, of whom 139,546 initiated GLP-1 RA therapy (mean age, 65.33 years; 90.2% male) and 448,622 initiated SGLT2 inhibitor therapy (mean age, 67.94 years; 95.3% male) between 2017 and 2024; groups were subsequently matched using propensity score-based inverse probability weighting.
• Cases of NAION were identified from medical records using standard diagnostic codes; cases diagnosed by an eye care specialist and repeat diagnoses were also evaluated.
• The 3-year cumulative incidence, cumulative incidence difference (CID), and cumulative incidence ratio of NAION were estimated.

TAKEAWAY:

• Over 3 years, individuals who started GLP-1 RAs had a small but statistically significant increase in the risk for NAION compared with those who started SGLT2 inhibitors — 39.07 vs 29.33 cases per 10,000 people (CID, 9.98 per 10,000 people; 95% CI, 3.48-14.03) — and a relative increase of about 35% (cumulative incidence ratio, 1.35; 95% CI, 1.11-1.51).
• The increased risk for NAION with the use of GLP-1 RAs was consistent across definitions: diagnosis by an eye care specialist (CID, 8.73; 95% CI, 2.46-12.89), repeat diagnoses (CID, 6.35; 95% CI, 2.40-9.65), and repeat diagnoses with a specialist (CID, 5.91; 95% CI, 2.00-8.88).
• Compared with the use of SGLT2 inhibitors, the use of GLP-1 RAs was not associated with an increased risk for other optic disorders such as diabetic retinopathy, macular degeneration, retinal vascular occlusion, or optic neuritis.
• The frequency of ophthalmology or optometry clinic visits during follow-up was found to be similar between the two groups, suggesting that the association with NAION was not due to differential surveillance.

IN PRACTICE

“GLP-1 RA use was associated with a modestly increased risk of NAION compared with [SGLT2 inhibitor] use. While the absolute risk remains low, the specificity of this finding may warrant heightened vigilance,” the authors of the study wrote.

SOURCE:

The study was led by Taeyoung Choi, MS, Clinical Epidemiology Center, Research and Development Service, VA St Louis Health Care System, St. Louis. It was published online on April 30, 2026, in JAMA Network Open.

LIMITATIONS:

The study cohort was older and predominantly male, limiting generalizability to other populations. Residual confounding, selection bias, and outcome misclassification could not be fully excluded.

DISCLOSURES:

The study was funded by the US Department of Veterans Affairs. Two authors reported being uncompensated consultants for Pfizer.

This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

A version of this article first appeared on Medscape.com.

TOPLINE:

A large cohort study found that the use of GLP-1 receptor agonists (GLP-1 RAs) over 3 years was associated with a modestly increased risk for nonarteritic anterior ischemic optic neuropathy (NAION) compared with the use of SGLT2 inhibitors in veterans with type 2 diabetes (T2D).

METHODOLOGY:

• Pharmacovigilance reports and emerging, but inconsistent, population-based studies suggest that the use of GLP-1 RAs may be linked to ocular adverse events, including a possible increased risk for NAION; however, it remains unclear whether the association is specific to NAION as compared with other optic disorders.
• Researchers conducted a target trial emulation study using nationwide electronic health records from the US Department of Veterans Affairs to compare the 3-year risk for NAION among veterans with T2D who initiated GLP-1 RAs vs SGLT2 inhibitors.
• The study included 588,168 veterans with T2D, of whom 139,546 initiated GLP-1 RA therapy (mean age, 65.33 years; 90.2% male) and 448,622 initiated SGLT2 inhibitor therapy (mean age, 67.94 years; 95.3% male) between 2017 and 2024; groups were subsequently matched using propensity score-based inverse probability weighting.
• Cases of NAION were identified from medical records using standard diagnostic codes; cases diagnosed by an eye care specialist and repeat diagnoses were also evaluated.
• The 3-year cumulative incidence, cumulative incidence difference (CID), and cumulative incidence ratio of NAION were estimated.

TAKEAWAY:

• Over 3 years, individuals who started GLP-1 RAs had a small but statistically significant increase in the risk for NAION compared with those who started SGLT2 inhibitors — 39.07 vs 29.33 cases per 10,000 people (CID, 9.98 per 10,000 people; 95% CI, 3.48-14.03) — and a relative increase of about 35% (cumulative incidence ratio, 1.35; 95% CI, 1.11-1.51).
• The increased risk for NAION with the use of GLP-1 RAs was consistent across definitions: diagnosis by an eye care specialist (CID, 8.73; 95% CI, 2.46-12.89), repeat diagnoses (CID, 6.35; 95% CI, 2.40-9.65), and repeat diagnoses with a specialist (CID, 5.91; 95% CI, 2.00-8.88).
• Compared with the use of SGLT2 inhibitors, the use of GLP-1 RAs was not associated with an increased risk for other optic disorders such as diabetic retinopathy, macular degeneration, retinal vascular occlusion, or optic neuritis.
• The frequency of ophthalmology or optometry clinic visits during follow-up was found to be similar between the two groups, suggesting that the association with NAION was not due to differential surveillance.

IN PRACTICE

“GLP-1 RA use was associated with a modestly increased risk of NAION compared with [SGLT2 inhibitor] use. While the absolute risk remains low, the specificity of this finding may warrant heightened vigilance,” the authors of the study wrote.

SOURCE:

The study was led by Taeyoung Choi, MS, Clinical Epidemiology Center, Research and Development Service, VA St Louis Health Care System, St. Louis. It was published online on April 30, 2026, in JAMA Network Open.

LIMITATIONS:

The study cohort was older and predominantly male, limiting generalizability to other populations. Residual confounding, selection bias, and outcome misclassification could not be fully excluded.

DISCLOSURES:

The study was funded by the US Department of Veterans Affairs. Two authors reported being uncompensated consultants for Pfizer.

This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

A version of this article first appeared on Medscape.com.

TOPLINE:

A large cohort study found that the use of GLP-1 receptor agonists (GLP-1 RAs) over 3 years was associated with a modestly increased risk for nonarteritic anterior ischemic optic neuropathy (NAION) compared with the use of SGLT2 inhibitors in veterans with type 2 diabetes (T2D).

METHODOLOGY:

• Pharmacovigilance reports and emerging, but inconsistent, population-based studies suggest that the use of GLP-1 RAs may be linked to ocular adverse events, including a possible increased risk for NAION; however, it remains unclear whether the association is specific to NAION as compared with other optic disorders.
• Researchers conducted a target trial emulation study using nationwide electronic health records from the US Department of Veterans Affairs to compare the 3-year risk for NAION among veterans with T2D who initiated GLP-1 RAs vs SGLT2 inhibitors.
• The study included 588,168 veterans with T2D, of whom 139,546 initiated GLP-1 RA therapy (mean age, 65.33 years; 90.2% male) and 448,622 initiated SGLT2 inhibitor therapy (mean age, 67.94 years; 95.3% male) between 2017 and 2024; groups were subsequently matched using propensity score-based inverse probability weighting.
• Cases of NAION were identified from medical records using standard diagnostic codes; cases diagnosed by an eye care specialist and repeat diagnoses were also evaluated.
• The 3-year cumulative incidence, cumulative incidence difference (CID), and cumulative incidence ratio of NAION were estimated.

TAKEAWAY:

• Over 3 years, individuals who started GLP-1 RAs had a small but statistically significant increase in the risk for NAION compared with those who started SGLT2 inhibitors — 39.07 vs 29.33 cases per 10,000 people (CID, 9.98 per 10,000 people; 95% CI, 3.48-14.03) — and a relative increase of about 35% (cumulative incidence ratio, 1.35; 95% CI, 1.11-1.51).
• The increased risk for NAION with the use of GLP-1 RAs was consistent across definitions: diagnosis by an eye care specialist (CID, 8.73; 95% CI, 2.46-12.89), repeat diagnoses (CID, 6.35; 95% CI, 2.40-9.65), and repeat diagnoses with a specialist (CID, 5.91; 95% CI, 2.00-8.88).
• Compared with the use of SGLT2 inhibitors, the use of GLP-1 RAs was not associated with an increased risk for other optic disorders such as diabetic retinopathy, macular degeneration, retinal vascular occlusion, or optic neuritis.
• The frequency of ophthalmology or optometry clinic visits during follow-up was found to be similar between the two groups, suggesting that the association with NAION was not due to differential surveillance.

IN PRACTICE

“GLP-1 RA use was associated with a modestly increased risk of NAION compared with [SGLT2 inhibitor] use. While the absolute risk remains low, the specificity of this finding may warrant heightened vigilance,” the authors of the study wrote.

SOURCE:

The study was led by Taeyoung Choi, MS, Clinical Epidemiology Center, Research and Development Service, VA St Louis Health Care System, St. Louis. It was published online on April 30, 2026, in JAMA Network Open.

LIMITATIONS:

The study cohort was older and predominantly male, limiting generalizability to other populations. Residual confounding, selection bias, and outcome misclassification could not be fully excluded.

DISCLOSURES:

The study was funded by the US Department of Veterans Affairs. Two authors reported being uncompensated consultants for Pfizer.

This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

A version of this article first appeared on Medscape.com.

The US Department of Veterans Affairs (VA) recently announced plans to offer $7 million in new transportation services grants that could benefit 4.7 million veterans who live in rural areas. The grants would expand free transportation to medical appointments, something VA Secretary Doug Collins said is designed to “help break down the geographic barriers to health care some rural veterans face.”

Funding could be distributed later in 2026 to veteran service organizations, state agencies, and groups that transport veterans for health care. Eligible veterans would not need to do anything—the transportation is free for those living in qualifying areas.

Travel time and distance from health care facilities are significant barriers to receiving appropriate and timely care. The 2014 Veterans Access, Choice and Accountability Act (Choice) was intended to improve timely access to outpatient health care for veterans by allowing them to receive care from community facilities paid for by the VA. Under Choice, eligible veterans become eligible to receive community care if they have to drive > 40 miles to the nearest VA facility or wait > 30 days for care. 

Even with this provision, many of the 2.7 million rural veterans enrolled in Veterans Health Administration (VHA) remained far from care. For instance, the VA Office of Rural Health says the closest facility for veterans in Hollis, Alaska, is > 1000 miles away. 

Moreover, 56% of rural veterans enrolled in VHA care are aged > 65 years, and more likely to be diagnosed with diabetes, high blood pressure, and heart conditions than veterans living in more urban areas. Although studies comparing health outcomes between rural and urban veterans are sparse, research has long shown that lacking access to routine health care may worsen long-term outcomes.  

The VA has also announced other initiatives aimed at improving health care for veterans, among them the opening of 34 new facilities. Other projects:

• The Electronic Health Record (EHR) modernization project resumed April 11 with new deployments in Michigan. The VA says the new EHR system will result in more consistent medical records, fewer repeated tests, and better coordination between VA facilities and military health services.

• In March, the VA announced a $112 million grant opportunity to strengthen community‑based suicide prevention programs, focusing on outreach outside traditional VA settings.

• In February, the VA said it raised its spending cap for in‑home and community‑based services for veterans with complex medical needs, adding coverage for veterans with spinal cord injuries, Amyotrophic Lateral Sclerosis, and others.

• In January, the VA announced plans to invest $4.8 billion in fiscal year 2026 to modernize, repair, and improve health care facilities nationwide via infrastructure upgrades, major building repairs, and improvements to EHR systems.

The US Department of Veterans Affairs (VA) recently announced plans to offer $7 million in new transportation services grants that could benefit 4.7 million veterans who live in rural areas. The grants would expand free transportation to medical appointments, something VA Secretary Doug Collins said is designed to “help break down the geographic barriers to health care some rural veterans face.”

Funding could be distributed later in 2026 to veteran service organizations, state agencies, and groups that transport veterans for health care. Eligible veterans would not need to do anything—the transportation is free for those living in qualifying areas.

Travel time and distance from health care facilities are significant barriers to receiving appropriate and timely care. The 2014 Veterans Access, Choice and Accountability Act (Choice) was intended to improve timely access to outpatient health care for veterans by allowing them to receive care from community facilities paid for by the VA. Under Choice, eligible veterans become eligible to receive community care if they have to drive > 40 miles to the nearest VA facility or wait > 30 days for care. 

Even with this provision, many of the 2.7 million rural veterans enrolled in Veterans Health Administration (VHA) remained far from care. For instance, the VA Office of Rural Health says the closest facility for veterans in Hollis, Alaska, is > 1000 miles away. 

Moreover, 56% of rural veterans enrolled in VHA care are aged > 65 years, and more likely to be diagnosed with diabetes, high blood pressure, and heart conditions than veterans living in more urban areas. Although studies comparing health outcomes between rural and urban veterans are sparse, research has long shown that lacking access to routine health care may worsen long-term outcomes.  

The VA has also announced other initiatives aimed at improving health care for veterans, among them the opening of 34 new facilities. Other projects:

• The Electronic Health Record (EHR) modernization project resumed April 11 with new deployments in Michigan. The VA says the new EHR system will result in more consistent medical records, fewer repeated tests, and better coordination between VA facilities and military health services.

• In March, the VA announced a $112 million grant opportunity to strengthen community‑based suicide prevention programs, focusing on outreach outside traditional VA settings.

• In February, the VA said it raised its spending cap for in‑home and community‑based services for veterans with complex medical needs, adding coverage for veterans with spinal cord injuries, Amyotrophic Lateral Sclerosis, and others.

• In January, the VA announced plans to invest $4.8 billion in fiscal year 2026 to modernize, repair, and improve health care facilities nationwide via infrastructure upgrades, major building repairs, and improvements to EHR systems.

The US Department of Veterans Affairs (VA) recently announced plans to offer $7 million in new transportation services grants that could benefit 4.7 million veterans who live in rural areas. The grants would expand free transportation to medical appointments, something VA Secretary Doug Collins said is designed to “help break down the geographic barriers to health care some rural veterans face.”

Funding could be distributed later in 2026 to veteran service organizations, state agencies, and groups that transport veterans for health care. Eligible veterans would not need to do anything—the transportation is free for those living in qualifying areas.

Travel time and distance from health care facilities are significant barriers to receiving appropriate and timely care. The 2014 Veterans Access, Choice and Accountability Act (Choice) was intended to improve timely access to outpatient health care for veterans by allowing them to receive care from community facilities paid for by the VA. Under Choice, eligible veterans become eligible to receive community care if they have to drive > 40 miles to the nearest VA facility or wait > 30 days for care. 

Even with this provision, many of the 2.7 million rural veterans enrolled in Veterans Health Administration (VHA) remained far from care. For instance, the VA Office of Rural Health says the closest facility for veterans in Hollis, Alaska, is > 1000 miles away. 

Moreover, 56% of rural veterans enrolled in VHA care are aged > 65 years, and more likely to be diagnosed with diabetes, high blood pressure, and heart conditions than veterans living in more urban areas. Although studies comparing health outcomes between rural and urban veterans are sparse, research has long shown that lacking access to routine health care may worsen long-term outcomes.  

The VA has also announced other initiatives aimed at improving health care for veterans, among them the opening of 34 new facilities. Other projects:

• The Electronic Health Record (EHR) modernization project resumed April 11 with new deployments in Michigan. The VA says the new EHR system will result in more consistent medical records, fewer repeated tests, and better coordination between VA facilities and military health services.

• In March, the VA announced a $112 million grant opportunity to strengthen community‑based suicide prevention programs, focusing on outreach outside traditional VA settings.

• In February, the VA said it raised its spending cap for in‑home and community‑based services for veterans with complex medical needs, adding coverage for veterans with spinal cord injuries, Amyotrophic Lateral Sclerosis, and others.

• In January, the VA announced plans to invest $4.8 billion in fiscal year 2026 to modernize, repair, and improve health care facilities nationwide via infrastructure upgrades, major building repairs, and improvements to EHR systems.

Cardiac rehabilitation (CR) remains dramatically underused among US veterans, as < 11% of eligible patients attend a single session and usage appears to be declining over time, a recently published retrospective cohort study reported. 

CR use is much lower among eligible patients across the US Department of Veterans Affairs (VA) compared with Medicare (10.4% vs. 28%, respectively), reported researchers at Veterans Affairs Connecticut Healthcare System and Yale School of Medicine, in JACC: Advances. 

The overall CR rate in the VA was lower than the 13.2% reported in a 2018 study. And while there was no significant difference in use between men and women, veterans from the poorest neighborhoods were less likely to take advantage of CR compared with veterans from the wealthiest neighborhoods (adjusted odds ratio, 0.82; P < .001).

“As providers, the time to act is now,” Merilyn Varghese, MD, MSc, said in an interview with Federal Practitioner. “We need to urgently get more of our veterans to cardiac rehab.”

As Varghese explained, “CR is a preventive intervention that has been shown to improve quality of life and reduce mortality and hospitalizations for patients with specific cardiac conditions.”

Patients may be eligible if they have experienced myocardial infarction (MI), percutaneous coronary intervention (PCI), coronary artery bypass surgery (CABG), heart transplant, valve surgery, stable angina, or stable heart failure. 

“CR combines multiple aspects of cardiac care such as exercise training, medication management, and behavioral assessments,” Varghese said. “For example, patients who have had a heart attack may have challenges in getting back to an exercise routine, managing new medications, and adjusting to life after such an event. CR can help bridge the gap between hospital to home.” In-person CR typically includes 3 sessions per week for 12 weeks.  

In 2024, a systematic review and meta-analysis reported that CR reduces all-cause mortality (relative risk, 0.74): “These results support the utilization of CR as a critical element in the management of further secondary prevention of CVDs (cardiovascular diseases).”

Examining VA Data

Researchers conducted the 2026 study “to better understand the current landscape of CR among veterans, particularly among women veterans who comprise a significant part of the veteran population but have previously been underrepresented in research,” Varghese said.

“Women veterans also share a different burden of cardiovascular risk factors, so understanding CR participation among both women and men veterans was of particular interest.”

The study tracked 82,496 VA-enrolled veterans eligible for CR from 2021-2023 (3.6% women). Average age of participants were 64.0 years among women and 71.5 years among men. Among women, 58.3% were White, and 31.8% were Black, and 2.24% were Asian. Among men, 71.9% were White, 18.8% were Black, and 2.3% were Asian. 

The rates of CR participation were low among both men (10.4%) and women (10.2%). Older people and Black patients were less likely to take part in CR than younger people and White patients, according to the study. Those who underwent CABG and PCI were more likely to participate in CR compared with those who had heart attacks only.

As for the gap in use between the wealthiest and poorest neighborhoods, Varghese said: “Area deprivation may compound some of the other barriers to CR access, including transportation difficulties, work responsibilities, and out-of-pocket costs.”

How can CR uptake be improved? “A key first step is understanding who can be referred, and second, to spend time discussing the importance of attending with veterans,” Varghese said. “Studies have shown that provider engagement and championing of CR are important positive facilitators that encourage CR participation.

“The VA has been at the forefront of innovation with the home-based CR program that offers veterans a way to attend CR remotely,” she added. “Expanding such novel methods of CR delivery is likely part of the solution to expand CR access.”

Outside Perspective: Make Referrals the Default

Justin Bachmann, MD, MPH, staff physician and research scientist at VA Tennessee Valley Healthcare System, told Federal Practitioner that CR is an American College of Cardiology/American Heart Association Class I recommended secondary prevention therapy following MI, PCI, and CABG “with strong evidence for reduced cardiovascular mortality and improved function and quality of life.”

Still, CR “has been persistently underused for decades as travel, cost, scheduling, and uneven geographic capacity create real logistical barriers,” said Bachmann, who serves as the medical director of a VA Office of Rural Health home-based CR program. 

Bachmann praised the study methodology and offered this advice to colleagues: “Embed CR referral in the post-MI, post-PCI, and post-CABG order sets so that referral is the default. Scale home-based CR well beyond the roughly 40 sites where it is currently available, and track facility-level referral and enrollment rates as quality measures.”

Preventive cardiology specialist Randal J. Thomas, MD, professor of Medicine at the Mayo Clinic in Rochester, Minn., echoed the importance of physician referral to Federal Practitioner.

“Patients can’t actually participate [directly] in most programs. They must have a physician referral,” he said. “The physician referral and the strength of referral is key. If a physician says, ‘You can go there if you want, but it’s not that important,’ the patients aren’t going to go.”

Outside Perspective: VA Deserves Blame

“The VA lags far behind most medical systems,” according to Quinn R. Pack, MD, associate professor of medicine at the University of Massachusetts Chan Medical School-Baystate. “Some of this is probably the patient population—more mental health problems, more smoking, more disease. But I’d squarely put most of this on the VA health system. They haven’t created the systems of care that make attending cardiac rehabilitation easy, reliable, and consistent.”

He noted that that automatic referral combined with a bedside visit by a liaison such as a representative of a CR program can double or triple enrollment.

“When physicians and nurses really encourage patients to go [to CR], these words are powerful,” Pack said. “When a patient enrolls in cardiac rehabilitation, we help them form new habits of exercise.”

No study fundings are reported. The Varghese discloses a relationship with the Veterans Health Administration. Other study authors had no disclosures. Bachmann disclosed a relationship with the VA. Pack and Thomas have no disclosures. 

Cardiac rehabilitation (CR) remains dramatically underused among US veterans, as < 11% of eligible patients attend a single session and usage appears to be declining over time, a recently published retrospective cohort study reported. 

CR use is much lower among eligible patients across the US Department of Veterans Affairs (VA) compared with Medicare (10.4% vs. 28%, respectively), reported researchers at Veterans Affairs Connecticut Healthcare System and Yale School of Medicine, in JACC: Advances. 

The overall CR rate in the VA was lower than the 13.2% reported in a 2018 study. And while there was no significant difference in use between men and women, veterans from the poorest neighborhoods were less likely to take advantage of CR compared with veterans from the wealthiest neighborhoods (adjusted odds ratio, 0.82; P < .001).

“As providers, the time to act is now,” Merilyn Varghese, MD, MSc, said in an interview with Federal Practitioner. “We need to urgently get more of our veterans to cardiac rehab.”

As Varghese explained, “CR is a preventive intervention that has been shown to improve quality of life and reduce mortality and hospitalizations for patients with specific cardiac conditions.”

Patients may be eligible if they have experienced myocardial infarction (MI), percutaneous coronary intervention (PCI), coronary artery bypass surgery (CABG), heart transplant, valve surgery, stable angina, or stable heart failure. 

“CR combines multiple aspects of cardiac care such as exercise training, medication management, and behavioral assessments,” Varghese said. “For example, patients who have had a heart attack may have challenges in getting back to an exercise routine, managing new medications, and adjusting to life after such an event. CR can help bridge the gap between hospital to home.” In-person CR typically includes 3 sessions per week for 12 weeks.  

In 2024, a systematic review and meta-analysis reported that CR reduces all-cause mortality (relative risk, 0.74): “These results support the utilization of CR as a critical element in the management of further secondary prevention of CVDs (cardiovascular diseases).”

Examining VA Data

Researchers conducted the 2026 study “to better understand the current landscape of CR among veterans, particularly among women veterans who comprise a significant part of the veteran population but have previously been underrepresented in research,” Varghese said.

“Women veterans also share a different burden of cardiovascular risk factors, so understanding CR participation among both women and men veterans was of particular interest.”

The study tracked 82,496 VA-enrolled veterans eligible for CR from 2021-2023 (3.6% women). Average age of participants were 64.0 years among women and 71.5 years among men. Among women, 58.3% were White, and 31.8% were Black, and 2.24% were Asian. Among men, 71.9% were White, 18.8% were Black, and 2.3% were Asian. 

The rates of CR participation were low among both men (10.4%) and women (10.2%). Older people and Black patients were less likely to take part in CR than younger people and White patients, according to the study. Those who underwent CABG and PCI were more likely to participate in CR compared with those who had heart attacks only.

As for the gap in use between the wealthiest and poorest neighborhoods, Varghese said: “Area deprivation may compound some of the other barriers to CR access, including transportation difficulties, work responsibilities, and out-of-pocket costs.”

How can CR uptake be improved? “A key first step is understanding who can be referred, and second, to spend time discussing the importance of attending with veterans,” Varghese said. “Studies have shown that provider engagement and championing of CR are important positive facilitators that encourage CR participation.

“The VA has been at the forefront of innovation with the home-based CR program that offers veterans a way to attend CR remotely,” she added. “Expanding such novel methods of CR delivery is likely part of the solution to expand CR access.”

Outside Perspective: Make Referrals the Default

Justin Bachmann, MD, MPH, staff physician and research scientist at VA Tennessee Valley Healthcare System, told Federal Practitioner that CR is an American College of Cardiology/American Heart Association Class I recommended secondary prevention therapy following MI, PCI, and CABG “with strong evidence for reduced cardiovascular mortality and improved function and quality of life.”

Still, CR “has been persistently underused for decades as travel, cost, scheduling, and uneven geographic capacity create real logistical barriers,” said Bachmann, who serves as the medical director of a VA Office of Rural Health home-based CR program. 

Bachmann praised the study methodology and offered this advice to colleagues: “Embed CR referral in the post-MI, post-PCI, and post-CABG order sets so that referral is the default. Scale home-based CR well beyond the roughly 40 sites where it is currently available, and track facility-level referral and enrollment rates as quality measures.”

Preventive cardiology specialist Randal J. Thomas, MD, professor of Medicine at the Mayo Clinic in Rochester, Minn., echoed the importance of physician referral to Federal Practitioner.

“Patients can’t actually participate [directly] in most programs. They must have a physician referral,” he said. “The physician referral and the strength of referral is key. If a physician says, ‘You can go there if you want, but it’s not that important,’ the patients aren’t going to go.”

Outside Perspective: VA Deserves Blame

“The VA lags far behind most medical systems,” according to Quinn R. Pack, MD, associate professor of medicine at the University of Massachusetts Chan Medical School-Baystate. “Some of this is probably the patient population—more mental health problems, more smoking, more disease. But I’d squarely put most of this on the VA health system. They haven’t created the systems of care that make attending cardiac rehabilitation easy, reliable, and consistent.”

He noted that that automatic referral combined with a bedside visit by a liaison such as a representative of a CR program can double or triple enrollment.

“When physicians and nurses really encourage patients to go [to CR], these words are powerful,” Pack said. “When a patient enrolls in cardiac rehabilitation, we help them form new habits of exercise.”

No study fundings are reported. The Varghese discloses a relationship with the Veterans Health Administration. Other study authors had no disclosures. Bachmann disclosed a relationship with the VA. Pack and Thomas have no disclosures. 

Cardiac rehabilitation (CR) remains dramatically underused among US veterans, as < 11% of eligible patients attend a single session and usage appears to be declining over time, a recently published retrospective cohort study reported. 

CR use is much lower among eligible patients across the US Department of Veterans Affairs (VA) compared with Medicare (10.4% vs. 28%, respectively), reported researchers at Veterans Affairs Connecticut Healthcare System and Yale School of Medicine, in JACC: Advances. 

The overall CR rate in the VA was lower than the 13.2% reported in a 2018 study. And while there was no significant difference in use between men and women, veterans from the poorest neighborhoods were less likely to take advantage of CR compared with veterans from the wealthiest neighborhoods (adjusted odds ratio, 0.82; P < .001).

“As providers, the time to act is now,” Merilyn Varghese, MD, MSc, said in an interview with Federal Practitioner. “We need to urgently get more of our veterans to cardiac rehab.”

As Varghese explained, “CR is a preventive intervention that has been shown to improve quality of life and reduce mortality and hospitalizations for patients with specific cardiac conditions.”

Patients may be eligible if they have experienced myocardial infarction (MI), percutaneous coronary intervention (PCI), coronary artery bypass surgery (CABG), heart transplant, valve surgery, stable angina, or stable heart failure. 

“CR combines multiple aspects of cardiac care such as exercise training, medication management, and behavioral assessments,” Varghese said. “For example, patients who have had a heart attack may have challenges in getting back to an exercise routine, managing new medications, and adjusting to life after such an event. CR can help bridge the gap between hospital to home.” In-person CR typically includes 3 sessions per week for 12 weeks.  

In 2024, a systematic review and meta-analysis reported that CR reduces all-cause mortality (relative risk, 0.74): “These results support the utilization of CR as a critical element in the management of further secondary prevention of CVDs (cardiovascular diseases).”

Examining VA Data

Researchers conducted the 2026 study “to better understand the current landscape of CR among veterans, particularly among women veterans who comprise a significant part of the veteran population but have previously been underrepresented in research,” Varghese said.

“Women veterans also share a different burden of cardiovascular risk factors, so understanding CR participation among both women and men veterans was of particular interest.”

The study tracked 82,496 VA-enrolled veterans eligible for CR from 2021-2023 (3.6% women). Average age of participants were 64.0 years among women and 71.5 years among men. Among women, 58.3% were White, and 31.8% were Black, and 2.24% were Asian. Among men, 71.9% were White, 18.8% were Black, and 2.3% were Asian. 

The rates of CR participation were low among both men (10.4%) and women (10.2%). Older people and Black patients were less likely to take part in CR than younger people and White patients, according to the study. Those who underwent CABG and PCI were more likely to participate in CR compared with those who had heart attacks only.

As for the gap in use between the wealthiest and poorest neighborhoods, Varghese said: “Area deprivation may compound some of the other barriers to CR access, including transportation difficulties, work responsibilities, and out-of-pocket costs.”

How can CR uptake be improved? “A key first step is understanding who can be referred, and second, to spend time discussing the importance of attending with veterans,” Varghese said. “Studies have shown that provider engagement and championing of CR are important positive facilitators that encourage CR participation.

“The VA has been at the forefront of innovation with the home-based CR program that offers veterans a way to attend CR remotely,” she added. “Expanding such novel methods of CR delivery is likely part of the solution to expand CR access.”

Outside Perspective: Make Referrals the Default

Justin Bachmann, MD, MPH, staff physician and research scientist at VA Tennessee Valley Healthcare System, told Federal Practitioner that CR is an American College of Cardiology/American Heart Association Class I recommended secondary prevention therapy following MI, PCI, and CABG “with strong evidence for reduced cardiovascular mortality and improved function and quality of life.”

Still, CR “has been persistently underused for decades as travel, cost, scheduling, and uneven geographic capacity create real logistical barriers,” said Bachmann, who serves as the medical director of a VA Office of Rural Health home-based CR program. 

Bachmann praised the study methodology and offered this advice to colleagues: “Embed CR referral in the post-MI, post-PCI, and post-CABG order sets so that referral is the default. Scale home-based CR well beyond the roughly 40 sites where it is currently available, and track facility-level referral and enrollment rates as quality measures.”

Preventive cardiology specialist Randal J. Thomas, MD, professor of Medicine at the Mayo Clinic in Rochester, Minn., echoed the importance of physician referral to Federal Practitioner.

“Patients can’t actually participate [directly] in most programs. They must have a physician referral,” he said. “The physician referral and the strength of referral is key. If a physician says, ‘You can go there if you want, but it’s not that important,’ the patients aren’t going to go.”

Outside Perspective: VA Deserves Blame

“The VA lags far behind most medical systems,” according to Quinn R. Pack, MD, associate professor of medicine at the University of Massachusetts Chan Medical School-Baystate. “Some of this is probably the patient population—more mental health problems, more smoking, more disease. But I’d squarely put most of this on the VA health system. They haven’t created the systems of care that make attending cardiac rehabilitation easy, reliable, and consistent.”

He noted that that automatic referral combined with a bedside visit by a liaison such as a representative of a CR program can double or triple enrollment.

“When physicians and nurses really encourage patients to go [to CR], these words are powerful,” Pack said. “When a patient enrolls in cardiac rehabilitation, we help them form new habits of exercise.”

No study fundings are reported. The Varghese discloses a relationship with the Veterans Health Administration. Other study authors had no disclosures. Bachmann disclosed a relationship with the VA. Pack and Thomas have no disclosures. 

CHICAGO — Exposure to toxic smoke from military burn pits may be putting millions of US veterans at risk for neurologic disorders, new research suggested, raising fresh questions about the long-term health consequences of a widely used wartime waste-disposal practice.

Investigators found that veterans who lived or worked near the open-air pits — used to burn everything from plastics to medical waste — were significantly more likely to develop conditions including headache and vertigo.

“It’s been estimated that over time, approximately 4 million veterans may have been exposed to the combustion of plastics, metals, medical waste, human waste, and other chemicals,” said study investigator Sarah Anthony, research assistant with the VA Headache Centers of Excellence and the Department of Neurology at Yale School of Medicine, New Haven, Connecticut.

The findings were presented on April 21 at the American Academy of Neurology (AAN) 2026 Annual Meeting.

Toxic Legacy

Open burn pits — large, open-air sites used to burn military waste — were widely used during US deployments in Iraq and Afghanistan after 9/11. The fires produced thick plumes of smoke containing a complex mix of hazardous pollutants, including fine particulate matter, volatile organic compounds, and carcinogenic chemicals, exposing service members who lived and worked nearby.

Amid growing concerns, the Department of Veterans Affairs (VA) established the Airborne Hazards and Open Burn Pit Registry in 2014 to study the long-term health effects of deployment-related airborne exposures, including burn pits, Anthony said.

Since its inception, multiple studies have linked burn pit exposure to respiratory conditions such as chronic bronchitis and chronic obstructive pulmonary disease, as well as cardiovascular issues such as hypertension. More recently, Anthony et al reported an association between burn pit exposure and incident headache.

To better understand whether those risks extend beyond previously reported conditions, the researchers set out to examine the relationship between burn pit exposure and a broader range of neurologic disorders.

Analyzing data from > 245,000 registry participants, researchers found that 66% had ≥ 1 neurologic diagnosis, largely driven by common conditions such as headache.

Those with the highest exposure — living near burn pits and performing related duties — had 36% higher odds of developing a neurologic disorder than less-exposed veterans (odds ratio [OR], 1.36).

The risk for any headache disorder was 57% higher (OR, 1.57) and the risk for vertigo was 25% higher (OR, 1.25) in those with the highest exposure levels than in their peers with lower burn pit exposure.

For every additional 6 months of exposure, the odds of developing any neurologic disorder, headache, or vertigo continued to rise, reinforcing concerns about long-term harm to the brain.

There were no statistically significant associations between burn pit exposure and several other neurologic diseases, including epilepsy and amyotrophic lateral sclerosis.

The researchers also found an inverse association between burn pit exposure and Parkinson’s disease, meaning exposed veterans appeared less likely to be diagnosed with the disorder. However, Anthony cautioned that this may reflect the relatively young age of the study population rather than a true protective effect.

Anthony emphasized that the findings are preliminary and may underestimate long-term risks as many neurologic diseases develop over decades. She also noted that burn pit exposure was based on self-reported registry data, which has the potential to introduce bias.

Additional work is needed to understand the neurologic sequela of deployment-related airborne hazards, including exposure to open burn pits “as this remains important for veteran health policy, long term surveillance, and clinical care,” she said.

Long-term monitoring is critical, particularly as exposed veterans age and further studies should consider leveraging data from the VA toxic exposure screening initiatives, which are now part of routine care, as mandated by the Promise to Address Comprehensive Toxics Act.

Predictable Associations, More Study Needed

These findings, said David D. Lo, MD, PhD, distinguished professor of biomedical sciences, University of California Riverside, School of Medicine, said this is “another study that aims to highlight an association between possible burn pit exposure and a variety of health effects.”

Given the well-established risks of inhaling smoke from burning mixed waste, the findings are not surprising, said Lo, who was not involved in the research.

He noted that the study has important limitations, particularly because exposure was based on self-reports, making it difficult to accurately measure how much smoke individual participants were actually exposed to.

“If these findings are suggestive, it is hoped that they spur very real direct funding for more detailed clinical studies on the mechanisms of how the burn pit exposure would actually be responsible for one or more of the clinical outcomes listed in this study, instead of just adding up more statistical correlations,” said Lo.

This study had no commercial funding. Disclosure information for study authors is available in the original study publication. Lo reported having no relevant disclosures.

A version of this article appeared on Medscape.com.

CHICAGO — Exposure to toxic smoke from military burn pits may be putting millions of US veterans at risk for neurologic disorders, new research suggested, raising fresh questions about the long-term health consequences of a widely used wartime waste-disposal practice.

Investigators found that veterans who lived or worked near the open-air pits — used to burn everything from plastics to medical waste — were significantly more likely to develop conditions including headache and vertigo.

“It’s been estimated that over time, approximately 4 million veterans may have been exposed to the combustion of plastics, metals, medical waste, human waste, and other chemicals,” said study investigator Sarah Anthony, research assistant with the VA Headache Centers of Excellence and the Department of Neurology at Yale School of Medicine, New Haven, Connecticut.

The findings were presented on April 21 at the American Academy of Neurology (AAN) 2026 Annual Meeting.

Toxic Legacy

Open burn pits — large, open-air sites used to burn military waste — were widely used during US deployments in Iraq and Afghanistan after 9/11. The fires produced thick plumes of smoke containing a complex mix of hazardous pollutants, including fine particulate matter, volatile organic compounds, and carcinogenic chemicals, exposing service members who lived and worked nearby.

Amid growing concerns, the Department of Veterans Affairs (VA) established the Airborne Hazards and Open Burn Pit Registry in 2014 to study the long-term health effects of deployment-related airborne exposures, including burn pits, Anthony said.

Since its inception, multiple studies have linked burn pit exposure to respiratory conditions such as chronic bronchitis and chronic obstructive pulmonary disease, as well as cardiovascular issues such as hypertension. More recently, Anthony et al reported an association between burn pit exposure and incident headache.

To better understand whether those risks extend beyond previously reported conditions, the researchers set out to examine the relationship between burn pit exposure and a broader range of neurologic disorders.

Analyzing data from > 245,000 registry participants, researchers found that 66% had ≥ 1 neurologic diagnosis, largely driven by common conditions such as headache.

Those with the highest exposure — living near burn pits and performing related duties — had 36% higher odds of developing a neurologic disorder than less-exposed veterans (odds ratio [OR], 1.36).

The risk for any headache disorder was 57% higher (OR, 1.57) and the risk for vertigo was 25% higher (OR, 1.25) in those with the highest exposure levels than in their peers with lower burn pit exposure.

For every additional 6 months of exposure, the odds of developing any neurologic disorder, headache, or vertigo continued to rise, reinforcing concerns about long-term harm to the brain.

There were no statistically significant associations between burn pit exposure and several other neurologic diseases, including epilepsy and amyotrophic lateral sclerosis.

The researchers also found an inverse association between burn pit exposure and Parkinson’s disease, meaning exposed veterans appeared less likely to be diagnosed with the disorder. However, Anthony cautioned that this may reflect the relatively young age of the study population rather than a true protective effect.

Anthony emphasized that the findings are preliminary and may underestimate long-term risks as many neurologic diseases develop over decades. She also noted that burn pit exposure was based on self-reported registry data, which has the potential to introduce bias.

Additional work is needed to understand the neurologic sequela of deployment-related airborne hazards, including exposure to open burn pits “as this remains important for veteran health policy, long term surveillance, and clinical care,” she said.

Long-term monitoring is critical, particularly as exposed veterans age and further studies should consider leveraging data from the VA toxic exposure screening initiatives, which are now part of routine care, as mandated by the Promise to Address Comprehensive Toxics Act.

Predictable Associations, More Study Needed

These findings, said David D. Lo, MD, PhD, distinguished professor of biomedical sciences, University of California Riverside, School of Medicine, said this is “another study that aims to highlight an association between possible burn pit exposure and a variety of health effects.”

Given the well-established risks of inhaling smoke from burning mixed waste, the findings are not surprising, said Lo, who was not involved in the research.

He noted that the study has important limitations, particularly because exposure was based on self-reports, making it difficult to accurately measure how much smoke individual participants were actually exposed to.

“If these findings are suggestive, it is hoped that they spur very real direct funding for more detailed clinical studies on the mechanisms of how the burn pit exposure would actually be responsible for one or more of the clinical outcomes listed in this study, instead of just adding up more statistical correlations,” said Lo.

This study had no commercial funding. Disclosure information for study authors is available in the original study publication. Lo reported having no relevant disclosures.

A version of this article appeared on Medscape.com.

CHICAGO — Exposure to toxic smoke from military burn pits may be putting millions of US veterans at risk for neurologic disorders, new research suggested, raising fresh questions about the long-term health consequences of a widely used wartime waste-disposal practice.

Investigators found that veterans who lived or worked near the open-air pits — used to burn everything from plastics to medical waste — were significantly more likely to develop conditions including headache and vertigo.

“It’s been estimated that over time, approximately 4 million veterans may have been exposed to the combustion of plastics, metals, medical waste, human waste, and other chemicals,” said study investigator Sarah Anthony, research assistant with the VA Headache Centers of Excellence and the Department of Neurology at Yale School of Medicine, New Haven, Connecticut.

The findings were presented on April 21 at the American Academy of Neurology (AAN) 2026 Annual Meeting.

Toxic Legacy

Open burn pits — large, open-air sites used to burn military waste — were widely used during US deployments in Iraq and Afghanistan after 9/11. The fires produced thick plumes of smoke containing a complex mix of hazardous pollutants, including fine particulate matter, volatile organic compounds, and carcinogenic chemicals, exposing service members who lived and worked nearby.

Amid growing concerns, the Department of Veterans Affairs (VA) established the Airborne Hazards and Open Burn Pit Registry in 2014 to study the long-term health effects of deployment-related airborne exposures, including burn pits, Anthony said.

Since its inception, multiple studies have linked burn pit exposure to respiratory conditions such as chronic bronchitis and chronic obstructive pulmonary disease, as well as cardiovascular issues such as hypertension. More recently, Anthony et al reported an association between burn pit exposure and incident headache.

To better understand whether those risks extend beyond previously reported conditions, the researchers set out to examine the relationship between burn pit exposure and a broader range of neurologic disorders.

Analyzing data from > 245,000 registry participants, researchers found that 66% had ≥ 1 neurologic diagnosis, largely driven by common conditions such as headache.

Those with the highest exposure — living near burn pits and performing related duties — had 36% higher odds of developing a neurologic disorder than less-exposed veterans (odds ratio [OR], 1.36).

The risk for any headache disorder was 57% higher (OR, 1.57) and the risk for vertigo was 25% higher (OR, 1.25) in those with the highest exposure levels than in their peers with lower burn pit exposure.

For every additional 6 months of exposure, the odds of developing any neurologic disorder, headache, or vertigo continued to rise, reinforcing concerns about long-term harm to the brain.

There were no statistically significant associations between burn pit exposure and several other neurologic diseases, including epilepsy and amyotrophic lateral sclerosis.

The researchers also found an inverse association between burn pit exposure and Parkinson’s disease, meaning exposed veterans appeared less likely to be diagnosed with the disorder. However, Anthony cautioned that this may reflect the relatively young age of the study population rather than a true protective effect.

Anthony emphasized that the findings are preliminary and may underestimate long-term risks as many neurologic diseases develop over decades. She also noted that burn pit exposure was based on self-reported registry data, which has the potential to introduce bias.

Additional work is needed to understand the neurologic sequela of deployment-related airborne hazards, including exposure to open burn pits “as this remains important for veteran health policy, long term surveillance, and clinical care,” she said.

Long-term monitoring is critical, particularly as exposed veterans age and further studies should consider leveraging data from the VA toxic exposure screening initiatives, which are now part of routine care, as mandated by the Promise to Address Comprehensive Toxics Act.

Predictable Associations, More Study Needed

These findings, said David D. Lo, MD, PhD, distinguished professor of biomedical sciences, University of California Riverside, School of Medicine, said this is “another study that aims to highlight an association between possible burn pit exposure and a variety of health effects.”

Given the well-established risks of inhaling smoke from burning mixed waste, the findings are not surprising, said Lo, who was not involved in the research.

He noted that the study has important limitations, particularly because exposure was based on self-reports, making it difficult to accurately measure how much smoke individual participants were actually exposed to.

“If these findings are suggestive, it is hoped that they spur very real direct funding for more detailed clinical studies on the mechanisms of how the burn pit exposure would actually be responsible for one or more of the clinical outcomes listed in this study, instead of just adding up more statistical correlations,” said Lo.

This study had no commercial funding. Disclosure information for study authors is available in the original study publication. Lo reported having no relevant disclosures.

A version of this article appeared on Medscape.com.