The American Journal of Orthopedics

Retearing after repair of the distal biceps tendon is rare.¹ Heterotopic ossification (HO) is also considered uncommon, though reported rates in the literature vary widely, depending on repair and follow-up methods.^1-3

In this article, we report a case of ruptured distal biceps tendon repaired with a 1-incision Endobutton technique with longitudinal clinical and imaging follow-up, and we discuss the potential biomechanical and rehabilitative implications of clinically occult retearing after repair.

This case is unique in that the patient was a physician who procured multiple magnetic resonance imaging (MRI) examinations during the postoperative period and again at 1-year follow-up. We witnessed formation of a small focus of HO, which entered and significantly narrowed the radioulnar space on forearm pronation on dynamic MRI. There was no obvious clinical evidence for retearing; high-grade partial-thickness tendon retearing was diagnosed on MRI. This prompted a gentler rehabilitation protocol. Subsequent scar formation and tendon remodeling allowed the patient to return to full activity by 1-year follow-up, confirming recent reports that intrasubstance signal abnormalities⁴ and even rerupture on MRI are not correlated with symptoms.⁵ The patient provided written informed consent for print and electronic publication of this case report.

Case Report

A healthy right-hand–dominant 32-year-old man was rock climbing when he heard a pop and felt sudden weakness in his right elbow. The injury occurred during eccentric contraction, while he was climbing a 45° overhanging wall with his right elbow fully extended and forearm maximally pronated. Immediately after injury, he noticed obvious deformity in the right arm. Before this incident, there was no history of elbow symptoms or any medication use.

Physical examination revealed distortion of the biceps with a palpable defect in the right elbow consistent with a complete biceps tendon rupture. This was confirmed on MRI, which showed avulsion of the distal biceps tendon from its insertion on the radius. There was 4 cm of proximal retraction of the tendon, which was kept at the level of the joint line by a partially intact lacertus fibrosis (Figure 1).

As the patient was physically active, operative treatment was chosen with the expectation of restoration to full function and strength. Six days after injury, surgery was performed using a 1-incision anterior approach with an Endobutton technique, as first described by Bain and colleagues⁶ and subsequently detailed by other authors.⁷ The diameter of the distal biceps tendon after attachment to the Endobutton (Arthrex, Naples, Florida) was measured, and a corresponding 7-mm unicortical tunnel was drilled into the radial tuberosity. During surgery, there was full range of motion (ROM) at the elbow and forearm. Before closure, the wound was copiously irrigated to minimize the potential of HO. In our practice, we do not routinely administer prophylactic anti-inflammatory drugs to low-risk patients because of the theoretical risks for delayed tendon–bone healing⁸ and inferior healing strength.⁹ The theoretical, expected postoperative appearance is illustrated in Figure 2.

For 7 days after surgery, the patient wore a posterior elbow splint in a flexed, supinated position. Afterward, rehabilitation initially consisted of passive ROM progressing to active ROM at postoperative week 4. Pronation was slow to return, but essentially full ROM was regained by 7 weeks after surgery. Seven weeks after surgery, a radiograph showed a small amount of HO near the radial tuberosity (Figure 3A). However, the patient was clinically progressing well, and by 9 weeks was comfortably performing slow, controlled arm curls with a 10-lb weight. Despite the clinical improvements, MRI 9 weeks after surgery showed high-grade partial-thickness retearing of the distal biceps tendon without significant retraction. With dynamic MRI, it was evident that the focus of HO near but external to the distal tendon entered the radioulnar space on pronation (Figures 3B–3D). On axial images of the center of the cortical tunnel, the short-axis diameter of the heterotopic bone measured 2.5 mm, and the bone clearly was occupying part of the radioulnar space during pronation. As the patient was not having pain and was increasing in strength, the clinical team resumed rehabilitation, albeit at a gentler pace.

By 1-year follow-up, the patient had returned to preinjury activity levels, which included rock climbing and weightlifting without pain or loss of strength. One year after surgery, radiographs and MRI showed maturation of heterotopic bone, which was incorporated with scar tissue along the remodeled distal biceps tendon remnant (Figures 4A-4C).

Discussion

Distal biceps tendon ruptures historically have been considered relatively rare injuries. Postrepair complications are uncommon but well known. HO has been described with all distal biceps tendon repair techniques, but rates vary depending on follow-up method. Given the data reported, HO is thought to have a higher incidence with the 2-incision technique than with the 1-incision technique.¹⁰ The literature includes fewer reports of HO with the Endobutton technique^11,12 than with the suture anchor technique.³ Incidence of HO after distal biceps tendon repair has been reported to be as high as 50%, with Marnitz and colleagues⁵ suggesting that its presence does not necessarily affect clinical outcome. This was confirmed in our patient’s case.

A much rarer complication of repair is rerupture, which can be asymptomatic or symptomatic.⁵ The most common failure site, discovered during surgery, is the fixation site.^2,13 The true incidence of rerupture is unknown, as MRI typically is not obtained for asymptomatic patients. However, Marnitz and colleagues⁵ recently found increased intratendinous signal and thickness of repaired tendons in the majority of intact postoperative cases and no significant correlation between any MRI features, including tendon rerupture, and clinical measures. This was confirmed in our patient’s case, in which the MRI-based diagnosis of partial retear was not correlated with adverse clinical outcome at 1-year follow-up. Marnitz and colleagues⁵ hypothesized that the increased thickness of the repaired tendon would predispose the patient to impingement.

Our patient had no demonstrable loss of motion during surgery. However, postoperative dynamic MRI clearly showed insufficient room in the pronated radioulnar space for both heterotopic bone and repaired biceps tendon. It is possible that a space-occupying peritendinous hematoma or HO soon after surgery caused early loss of pronation. In a study of 10 volunteers, mean radioulnar distance was 4.0 mm (range, 2.1-6.0 mm) at its minimum in pronation.¹⁴ We used the same technique to measure our patient’s radioulnar space in active semipronation: 7 mm. This diameter was the same as that of the distal biceps tendon during surgery (Figure 3D). Had our patient been in maximum pronation during imaging, we would have expected a further decrease in radioulnar distance. Given the insufficient room in this case, it is possible that, during the attempt to regain full pronation, attritional wear of the repaired biceps tendon occurred with a corresponding maturation of the focus of heterotopic bone. Supporting this theory is the patient’s lack of history of traumatic loading, which would have suggested tensile failure of the repair. By 1-year follow-up, scar-tissue maturation and remodeling had occurred, and there was sufficient overall biomechanical strength to withstand return to normal activity.

The literature includes multiple reports of in vitro biomechanical studies of various types of distal biceps tendon fixation,^15-17 and multiple authors have demonstrated the superior pullout strength of cortical fixation buttons,^18,19 such as the Endobutton. It is important to note that all biomechanical tests are performed in cadaveric specimens and are therefore likely applicable only at time zero, after in vivo repair. In part stemming from the results of these cadaveric biomechanical tests, earlier and more aggressive rehabilitation protocols have been developed with the assumption that time zero is the weakest point.²⁰ If in fact the native repaired biceps tendon is retorn and remodeled, there will exist a nadir in strength because of the high concentration of biomechanically inferior type III collagen in scar tissue (as opposed to the very strong type I collagen in native tendons).²¹ In the absence of complete rerupture, biomechanical strength would continue to improve during scar maturation and continued healing, leading to the typical excellent clinical result, as seen in our case.

This case report illustrates the dynamic MRI appearance of a small focus of HO after distal biceps tendon repair and adds to the time-zero cadaveric data of distal biceps tendon repair. The small focus of HO near the repaired distal tendon may have caused tendon impingement in pronation because of its space-occupying nature and possible attritional tendon wear. A gentler rehabilitation protocol for this pattern of HO, during a period in which biomechanically inferior scar tissue is maturing, may be warranted. Despite the high rates of clinical success with distal biceps tendon repair, there is lack of agreement between ex vivo cadaveric studies and the in vivo scenario. A prospective study involving a larger series of patients with postoperative dynamic MRI examinations would be useful to better understand the true in vivo course of distal biceps tendon repair.

Retearing after repair of the distal biceps tendon is rare.¹ Heterotopic ossification (HO) is also considered uncommon, though reported rates in the literature vary widely, depending on repair and follow-up methods.^1-3

In this article, we report a case of ruptured distal biceps tendon repaired with a 1-incision Endobutton technique with longitudinal clinical and imaging follow-up, and we discuss the potential biomechanical and rehabilitative implications of clinically occult retearing after repair.

This case is unique in that the patient was a physician who procured multiple magnetic resonance imaging (MRI) examinations during the postoperative period and again at 1-year follow-up. We witnessed formation of a small focus of HO, which entered and significantly narrowed the radioulnar space on forearm pronation on dynamic MRI. There was no obvious clinical evidence for retearing; high-grade partial-thickness tendon retearing was diagnosed on MRI. This prompted a gentler rehabilitation protocol. Subsequent scar formation and tendon remodeling allowed the patient to return to full activity by 1-year follow-up, confirming recent reports that intrasubstance signal abnormalities⁴ and even rerupture on MRI are not correlated with symptoms.⁵ The patient provided written informed consent for print and electronic publication of this case report.

Case Report

A healthy right-hand–dominant 32-year-old man was rock climbing when he heard a pop and felt sudden weakness in his right elbow. The injury occurred during eccentric contraction, while he was climbing a 45° overhanging wall with his right elbow fully extended and forearm maximally pronated. Immediately after injury, he noticed obvious deformity in the right arm. Before this incident, there was no history of elbow symptoms or any medication use.

Physical examination revealed distortion of the biceps with a palpable defect in the right elbow consistent with a complete biceps tendon rupture. This was confirmed on MRI, which showed avulsion of the distal biceps tendon from its insertion on the radius. There was 4 cm of proximal retraction of the tendon, which was kept at the level of the joint line by a partially intact lacertus fibrosis (Figure 1).

As the patient was physically active, operative treatment was chosen with the expectation of restoration to full function and strength. Six days after injury, surgery was performed using a 1-incision anterior approach with an Endobutton technique, as first described by Bain and colleagues⁶ and subsequently detailed by other authors.⁷ The diameter of the distal biceps tendon after attachment to the Endobutton (Arthrex, Naples, Florida) was measured, and a corresponding 7-mm unicortical tunnel was drilled into the radial tuberosity. During surgery, there was full range of motion (ROM) at the elbow and forearm. Before closure, the wound was copiously irrigated to minimize the potential of HO. In our practice, we do not routinely administer prophylactic anti-inflammatory drugs to low-risk patients because of the theoretical risks for delayed tendon–bone healing⁸ and inferior healing strength.⁹ The theoretical, expected postoperative appearance is illustrated in Figure 2.

For 7 days after surgery, the patient wore a posterior elbow splint in a flexed, supinated position. Afterward, rehabilitation initially consisted of passive ROM progressing to active ROM at postoperative week 4. Pronation was slow to return, but essentially full ROM was regained by 7 weeks after surgery. Seven weeks after surgery, a radiograph showed a small amount of HO near the radial tuberosity (Figure 3A). However, the patient was clinically progressing well, and by 9 weeks was comfortably performing slow, controlled arm curls with a 10-lb weight. Despite the clinical improvements, MRI 9 weeks after surgery showed high-grade partial-thickness retearing of the distal biceps tendon without significant retraction. With dynamic MRI, it was evident that the focus of HO near but external to the distal tendon entered the radioulnar space on pronation (Figures 3B–3D). On axial images of the center of the cortical tunnel, the short-axis diameter of the heterotopic bone measured 2.5 mm, and the bone clearly was occupying part of the radioulnar space during pronation. As the patient was not having pain and was increasing in strength, the clinical team resumed rehabilitation, albeit at a gentler pace.

By 1-year follow-up, the patient had returned to preinjury activity levels, which included rock climbing and weightlifting without pain or loss of strength. One year after surgery, radiographs and MRI showed maturation of heterotopic bone, which was incorporated with scar tissue along the remodeled distal biceps tendon remnant (Figures 4A-4C).

Discussion

Distal biceps tendon ruptures historically have been considered relatively rare injuries. Postrepair complications are uncommon but well known. HO has been described with all distal biceps tendon repair techniques, but rates vary depending on follow-up method. Given the data reported, HO is thought to have a higher incidence with the 2-incision technique than with the 1-incision technique.¹⁰ The literature includes fewer reports of HO with the Endobutton technique^11,12 than with the suture anchor technique.³ Incidence of HO after distal biceps tendon repair has been reported to be as high as 50%, with Marnitz and colleagues⁵ suggesting that its presence does not necessarily affect clinical outcome. This was confirmed in our patient’s case.

A much rarer complication of repair is rerupture, which can be asymptomatic or symptomatic.⁵ The most common failure site, discovered during surgery, is the fixation site.^2,13 The true incidence of rerupture is unknown, as MRI typically is not obtained for asymptomatic patients. However, Marnitz and colleagues⁵ recently found increased intratendinous signal and thickness of repaired tendons in the majority of intact postoperative cases and no significant correlation between any MRI features, including tendon rerupture, and clinical measures. This was confirmed in our patient’s case, in which the MRI-based diagnosis of partial retear was not correlated with adverse clinical outcome at 1-year follow-up. Marnitz and colleagues⁵ hypothesized that the increased thickness of the repaired tendon would predispose the patient to impingement.

Our patient had no demonstrable loss of motion during surgery. However, postoperative dynamic MRI clearly showed insufficient room in the pronated radioulnar space for both heterotopic bone and repaired biceps tendon. It is possible that a space-occupying peritendinous hematoma or HO soon after surgery caused early loss of pronation. In a study of 10 volunteers, mean radioulnar distance was 4.0 mm (range, 2.1-6.0 mm) at its minimum in pronation.¹⁴ We used the same technique to measure our patient’s radioulnar space in active semipronation: 7 mm. This diameter was the same as that of the distal biceps tendon during surgery (Figure 3D). Had our patient been in maximum pronation during imaging, we would have expected a further decrease in radioulnar distance. Given the insufficient room in this case, it is possible that, during the attempt to regain full pronation, attritional wear of the repaired biceps tendon occurred with a corresponding maturation of the focus of heterotopic bone. Supporting this theory is the patient’s lack of history of traumatic loading, which would have suggested tensile failure of the repair. By 1-year follow-up, scar-tissue maturation and remodeling had occurred, and there was sufficient overall biomechanical strength to withstand return to normal activity.

The literature includes multiple reports of in vitro biomechanical studies of various types of distal biceps tendon fixation,^15-17 and multiple authors have demonstrated the superior pullout strength of cortical fixation buttons,^18,19 such as the Endobutton. It is important to note that all biomechanical tests are performed in cadaveric specimens and are therefore likely applicable only at time zero, after in vivo repair. In part stemming from the results of these cadaveric biomechanical tests, earlier and more aggressive rehabilitation protocols have been developed with the assumption that time zero is the weakest point.²⁰ If in fact the native repaired biceps tendon is retorn and remodeled, there will exist a nadir in strength because of the high concentration of biomechanically inferior type III collagen in scar tissue (as opposed to the very strong type I collagen in native tendons).²¹ In the absence of complete rerupture, biomechanical strength would continue to improve during scar maturation and continued healing, leading to the typical excellent clinical result, as seen in our case.

This case report illustrates the dynamic MRI appearance of a small focus of HO after distal biceps tendon repair and adds to the time-zero cadaveric data of distal biceps tendon repair. The small focus of HO near the repaired distal tendon may have caused tendon impingement in pronation because of its space-occupying nature and possible attritional tendon wear. A gentler rehabilitation protocol for this pattern of HO, during a period in which biomechanically inferior scar tissue is maturing, may be warranted. Despite the high rates of clinical success with distal biceps tendon repair, there is lack of agreement between ex vivo cadaveric studies and the in vivo scenario. A prospective study involving a larger series of patients with postoperative dynamic MRI examinations would be useful to better understand the true in vivo course of distal biceps tendon repair.

Retearing after repair of the distal biceps tendon is rare.¹ Heterotopic ossification (HO) is also considered uncommon, though reported rates in the literature vary widely, depending on repair and follow-up methods.^1-3

In this article, we report a case of ruptured distal biceps tendon repaired with a 1-incision Endobutton technique with longitudinal clinical and imaging follow-up, and we discuss the potential biomechanical and rehabilitative implications of clinically occult retearing after repair.

This case is unique in that the patient was a physician who procured multiple magnetic resonance imaging (MRI) examinations during the postoperative period and again at 1-year follow-up. We witnessed formation of a small focus of HO, which entered and significantly narrowed the radioulnar space on forearm pronation on dynamic MRI. There was no obvious clinical evidence for retearing; high-grade partial-thickness tendon retearing was diagnosed on MRI. This prompted a gentler rehabilitation protocol. Subsequent scar formation and tendon remodeling allowed the patient to return to full activity by 1-year follow-up, confirming recent reports that intrasubstance signal abnormalities⁴ and even rerupture on MRI are not correlated with symptoms.⁵ The patient provided written informed consent for print and electronic publication of this case report.

Case Report

A healthy right-hand–dominant 32-year-old man was rock climbing when he heard a pop and felt sudden weakness in his right elbow. The injury occurred during eccentric contraction, while he was climbing a 45° overhanging wall with his right elbow fully extended and forearm maximally pronated. Immediately after injury, he noticed obvious deformity in the right arm. Before this incident, there was no history of elbow symptoms or any medication use.

Physical examination revealed distortion of the biceps with a palpable defect in the right elbow consistent with a complete biceps tendon rupture. This was confirmed on MRI, which showed avulsion of the distal biceps tendon from its insertion on the radius. There was 4 cm of proximal retraction of the tendon, which was kept at the level of the joint line by a partially intact lacertus fibrosis (Figure 1).

As the patient was physically active, operative treatment was chosen with the expectation of restoration to full function and strength. Six days after injury, surgery was performed using a 1-incision anterior approach with an Endobutton technique, as first described by Bain and colleagues⁶ and subsequently detailed by other authors.⁷ The diameter of the distal biceps tendon after attachment to the Endobutton (Arthrex, Naples, Florida) was measured, and a corresponding 7-mm unicortical tunnel was drilled into the radial tuberosity. During surgery, there was full range of motion (ROM) at the elbow and forearm. Before closure, the wound was copiously irrigated to minimize the potential of HO. In our practice, we do not routinely administer prophylactic anti-inflammatory drugs to low-risk patients because of the theoretical risks for delayed tendon–bone healing⁸ and inferior healing strength.⁹ The theoretical, expected postoperative appearance is illustrated in Figure 2.

For 7 days after surgery, the patient wore a posterior elbow splint in a flexed, supinated position. Afterward, rehabilitation initially consisted of passive ROM progressing to active ROM at postoperative week 4. Pronation was slow to return, but essentially full ROM was regained by 7 weeks after surgery. Seven weeks after surgery, a radiograph showed a small amount of HO near the radial tuberosity (Figure 3A). However, the patient was clinically progressing well, and by 9 weeks was comfortably performing slow, controlled arm curls with a 10-lb weight. Despite the clinical improvements, MRI 9 weeks after surgery showed high-grade partial-thickness retearing of the distal biceps tendon without significant retraction. With dynamic MRI, it was evident that the focus of HO near but external to the distal tendon entered the radioulnar space on pronation (Figures 3B–3D). On axial images of the center of the cortical tunnel, the short-axis diameter of the heterotopic bone measured 2.5 mm, and the bone clearly was occupying part of the radioulnar space during pronation. As the patient was not having pain and was increasing in strength, the clinical team resumed rehabilitation, albeit at a gentler pace.

By 1-year follow-up, the patient had returned to preinjury activity levels, which included rock climbing and weightlifting without pain or loss of strength. One year after surgery, radiographs and MRI showed maturation of heterotopic bone, which was incorporated with scar tissue along the remodeled distal biceps tendon remnant (Figures 4A-4C).

Discussion

Distal biceps tendon ruptures historically have been considered relatively rare injuries. Postrepair complications are uncommon but well known. HO has been described with all distal biceps tendon repair techniques, but rates vary depending on follow-up method. Given the data reported, HO is thought to have a higher incidence with the 2-incision technique than with the 1-incision technique.¹⁰ The literature includes fewer reports of HO with the Endobutton technique^11,12 than with the suture anchor technique.³ Incidence of HO after distal biceps tendon repair has been reported to be as high as 50%, with Marnitz and colleagues⁵ suggesting that its presence does not necessarily affect clinical outcome. This was confirmed in our patient’s case.

A much rarer complication of repair is rerupture, which can be asymptomatic or symptomatic.⁵ The most common failure site, discovered during surgery, is the fixation site.^2,13 The true incidence of rerupture is unknown, as MRI typically is not obtained for asymptomatic patients. However, Marnitz and colleagues⁵ recently found increased intratendinous signal and thickness of repaired tendons in the majority of intact postoperative cases and no significant correlation between any MRI features, including tendon rerupture, and clinical measures. This was confirmed in our patient’s case, in which the MRI-based diagnosis of partial retear was not correlated with adverse clinical outcome at 1-year follow-up. Marnitz and colleagues⁵ hypothesized that the increased thickness of the repaired tendon would predispose the patient to impingement.

Our patient had no demonstrable loss of motion during surgery. However, postoperative dynamic MRI clearly showed insufficient room in the pronated radioulnar space for both heterotopic bone and repaired biceps tendon. It is possible that a space-occupying peritendinous hematoma or HO soon after surgery caused early loss of pronation. In a study of 10 volunteers, mean radioulnar distance was 4.0 mm (range, 2.1-6.0 mm) at its minimum in pronation.¹⁴ We used the same technique to measure our patient’s radioulnar space in active semipronation: 7 mm. This diameter was the same as that of the distal biceps tendon during surgery (Figure 3D). Had our patient been in maximum pronation during imaging, we would have expected a further decrease in radioulnar distance. Given the insufficient room in this case, it is possible that, during the attempt to regain full pronation, attritional wear of the repaired biceps tendon occurred with a corresponding maturation of the focus of heterotopic bone. Supporting this theory is the patient’s lack of history of traumatic loading, which would have suggested tensile failure of the repair. By 1-year follow-up, scar-tissue maturation and remodeling had occurred, and there was sufficient overall biomechanical strength to withstand return to normal activity.

The literature includes multiple reports of in vitro biomechanical studies of various types of distal biceps tendon fixation,^15-17 and multiple authors have demonstrated the superior pullout strength of cortical fixation buttons,^18,19 such as the Endobutton. It is important to note that all biomechanical tests are performed in cadaveric specimens and are therefore likely applicable only at time zero, after in vivo repair. In part stemming from the results of these cadaveric biomechanical tests, earlier and more aggressive rehabilitation protocols have been developed with the assumption that time zero is the weakest point.²⁰ If in fact the native repaired biceps tendon is retorn and remodeled, there will exist a nadir in strength because of the high concentration of biomechanically inferior type III collagen in scar tissue (as opposed to the very strong type I collagen in native tendons).²¹ In the absence of complete rerupture, biomechanical strength would continue to improve during scar maturation and continued healing, leading to the typical excellent clinical result, as seen in our case.

This case report illustrates the dynamic MRI appearance of a small focus of HO after distal biceps tendon repair and adds to the time-zero cadaveric data of distal biceps tendon repair. The small focus of HO near the repaired distal tendon may have caused tendon impingement in pronation because of its space-occupying nature and possible attritional tendon wear. A gentler rehabilitation protocol for this pattern of HO, during a period in which biomechanically inferior scar tissue is maturing, may be warranted. Despite the high rates of clinical success with distal biceps tendon repair, there is lack of agreement between ex vivo cadaveric studies and the in vivo scenario. A prospective study involving a larger series of patients with postoperative dynamic MRI examinations would be useful to better understand the true in vivo course of distal biceps tendon repair.

New research confirms that sleep disturbances are linked to pain and depression, but not disability, among patients with osteoarthritis (OA). Study results published online ahead of print October 6 in Arthritis Care & Research found that poor sleep increases depression and disability, but does not worsen pain over time.

“Sleep disturbance is a common complaint among those with pain, particularly among those with OA,” said Patricia A. Parmelee, PhD, Director, Center for Mental Health & Aging, Professor, Department of Psychology at The University of Alabama in Tuscaloosa. “Our research is unique as we investigate the complex relationships among sleep, OA-related pain, disability and depressed mood simultaneously in a single study.”

For the study, 288 patients with knee OA provided information on pain, sleep disturbances, functional limitations, and depressive symptoms. Researchers recruited participants from diverse settings to gather a broad representation of OA subjects. Sleep disturbances at the start of the study were used to predict changes in pain, disability, and depression after a one-year period.

Findings indicated that sleep was independently associated with pain and depression at baseline. Disability was not linked to baseline sleep disturbances. In individuals with high pain levels, the combination of poor sleep and pain exacerbated depression. Sleep disturbance at baseline predicted increased depression and disability, but not pain at one-year follow-up.

“This study shows that depression plays a strong role in the sleep-pain connection, particularly with severe pain,” Dr. Parmelee and colleagues said. Further investigation of sleep in disability progression may lead to new interventions that disrupt the cycle of OA distress.”

New research confirms that sleep disturbances are linked to pain and depression, but not disability, among patients with osteoarthritis (OA). Study results published online ahead of print October 6 in Arthritis Care & Research found that poor sleep increases depression and disability, but does not worsen pain over time.

“Sleep disturbance is a common complaint among those with pain, particularly among those with OA,” said Patricia A. Parmelee, PhD, Director, Center for Mental Health & Aging, Professor, Department of Psychology at The University of Alabama in Tuscaloosa. “Our research is unique as we investigate the complex relationships among sleep, OA-related pain, disability and depressed mood simultaneously in a single study.”

For the study, 288 patients with knee OA provided information on pain, sleep disturbances, functional limitations, and depressive symptoms. Researchers recruited participants from diverse settings to gather a broad representation of OA subjects. Sleep disturbances at the start of the study were used to predict changes in pain, disability, and depression after a one-year period.

Findings indicated that sleep was independently associated with pain and depression at baseline. Disability was not linked to baseline sleep disturbances. In individuals with high pain levels, the combination of poor sleep and pain exacerbated depression. Sleep disturbance at baseline predicted increased depression and disability, but not pain at one-year follow-up.

“This study shows that depression plays a strong role in the sleep-pain connection, particularly with severe pain,” Dr. Parmelee and colleagues said. Further investigation of sleep in disability progression may lead to new interventions that disrupt the cycle of OA distress.”

New research confirms that sleep disturbances are linked to pain and depression, but not disability, among patients with osteoarthritis (OA). Study results published online ahead of print October 6 in Arthritis Care & Research found that poor sleep increases depression and disability, but does not worsen pain over time.

“Sleep disturbance is a common complaint among those with pain, particularly among those with OA,” said Patricia A. Parmelee, PhD, Director, Center for Mental Health & Aging, Professor, Department of Psychology at The University of Alabama in Tuscaloosa. “Our research is unique as we investigate the complex relationships among sleep, OA-related pain, disability and depressed mood simultaneously in a single study.”

For the study, 288 patients with knee OA provided information on pain, sleep disturbances, functional limitations, and depressive symptoms. Researchers recruited participants from diverse settings to gather a broad representation of OA subjects. Sleep disturbances at the start of the study were used to predict changes in pain, disability, and depression after a one-year period.

Findings indicated that sleep was independently associated with pain and depression at baseline. Disability was not linked to baseline sleep disturbances. In individuals with high pain levels, the combination of poor sleep and pain exacerbated depression. Sleep disturbance at baseline predicted increased depression and disability, but not pain at one-year follow-up.

“This study shows that depression plays a strong role in the sleep-pain connection, particularly with severe pain,” Dr. Parmelee and colleagues said. Further investigation of sleep in disability progression may lead to new interventions that disrupt the cycle of OA distress.”

Several recent studies, which include a controlled study of first-time anterior cruciate ligament (ACL) injuries in Vermont high school and college athletic team members—conducted by Bruce Beynnon, PhD, University of Vermont McClure Professor of Musculoskeletal Research, Director of Research, Department of Orthopaedics and Rehabilitation and research colleagues—have examined multiple factors such as the size of the femoral notch to explain why some people are at greater risk for injury than others.

In a study published in the August issue of American Journal of Sports Medicine, Dr. Beynnon and colleagues have “very accurately characterized the incidence rate and magnitude of this problem in Vermont.”

The investigators examined 88 student athletes (27 male and 61 female) who suffered first-time, noncontact ACL injuries during the study and compared their measurements, which were taken using MRI, to a non-injured control group of 88 athletes (same male-female breakdown) from the same teams, with the same extrinsic factors (eg, environment, playing surface, training, footwear, level of competition, and coaching). One of the findings that study authors discovered is that the risk of injury increased as the size of the femoral notch and ACL decreases.

In a parallel five-year epidemiological study, also published in same issue, researchers reported on the effects of level of competition, sport, and sex on the incidence of first-time noncontact ACL injuries.

For this study, Dr. Beynnon and colleagues collected data from 38 institutions located throughout Vermont. Colleges reported 48 ACL injuries during the sport seasons studied, while high schools reported 53 injuries. The research team learned that college athletes had a significantly higher ACL injury risk than high school athletes and that female athletes were two times more at risk for ACL injuries than males. In comparison to athletes taking part in Lacrosse, risk of ACL injury was significantly greater among those participating in soccer and rugby.

“An athlete’s risk of having a first-time noncontact ACL injury is independently influenced by level of competition, the participant’s sex, and type of sport they participate in, and there are no interactions between their effects. Female college athletes have the highest risk of having a first-time noncontact ACL injury among the groups studied,” Dr. Beynnon and colleagues stated.

Several recent studies, which include a controlled study of first-time anterior cruciate ligament (ACL) injuries in Vermont high school and college athletic team members—conducted by Bruce Beynnon, PhD, University of Vermont McClure Professor of Musculoskeletal Research, Director of Research, Department of Orthopaedics and Rehabilitation and research colleagues—have examined multiple factors such as the size of the femoral notch to explain why some people are at greater risk for injury than others.

In a study published in the August issue of American Journal of Sports Medicine, Dr. Beynnon and colleagues have “very accurately characterized the incidence rate and magnitude of this problem in Vermont.”

The investigators examined 88 student athletes (27 male and 61 female) who suffered first-time, noncontact ACL injuries during the study and compared their measurements, which were taken using MRI, to a non-injured control group of 88 athletes (same male-female breakdown) from the same teams, with the same extrinsic factors (eg, environment, playing surface, training, footwear, level of competition, and coaching). One of the findings that study authors discovered is that the risk of injury increased as the size of the femoral notch and ACL decreases.

In a parallel five-year epidemiological study, also published in same issue, researchers reported on the effects of level of competition, sport, and sex on the incidence of first-time noncontact ACL injuries.

For this study, Dr. Beynnon and colleagues collected data from 38 institutions located throughout Vermont. Colleges reported 48 ACL injuries during the sport seasons studied, while high schools reported 53 injuries. The research team learned that college athletes had a significantly higher ACL injury risk than high school athletes and that female athletes were two times more at risk for ACL injuries than males. In comparison to athletes taking part in Lacrosse, risk of ACL injury was significantly greater among those participating in soccer and rugby.

“An athlete’s risk of having a first-time noncontact ACL injury is independently influenced by level of competition, the participant’s sex, and type of sport they participate in, and there are no interactions between their effects. Female college athletes have the highest risk of having a first-time noncontact ACL injury among the groups studied,” Dr. Beynnon and colleagues stated.

Several recent studies, which include a controlled study of first-time anterior cruciate ligament (ACL) injuries in Vermont high school and college athletic team members—conducted by Bruce Beynnon, PhD, University of Vermont McClure Professor of Musculoskeletal Research, Director of Research, Department of Orthopaedics and Rehabilitation and research colleagues—have examined multiple factors such as the size of the femoral notch to explain why some people are at greater risk for injury than others.

In a study published in the August issue of American Journal of Sports Medicine, Dr. Beynnon and colleagues have “very accurately characterized the incidence rate and magnitude of this problem in Vermont.”

The investigators examined 88 student athletes (27 male and 61 female) who suffered first-time, noncontact ACL injuries during the study and compared their measurements, which were taken using MRI, to a non-injured control group of 88 athletes (same male-female breakdown) from the same teams, with the same extrinsic factors (eg, environment, playing surface, training, footwear, level of competition, and coaching). One of the findings that study authors discovered is that the risk of injury increased as the size of the femoral notch and ACL decreases.

In a parallel five-year epidemiological study, also published in same issue, researchers reported on the effects of level of competition, sport, and sex on the incidence of first-time noncontact ACL injuries.

For this study, Dr. Beynnon and colleagues collected data from 38 institutions located throughout Vermont. Colleges reported 48 ACL injuries during the sport seasons studied, while high schools reported 53 injuries. The research team learned that college athletes had a significantly higher ACL injury risk than high school athletes and that female athletes were two times more at risk for ACL injuries than males. In comparison to athletes taking part in Lacrosse, risk of ACL injury was significantly greater among those participating in soccer and rugby.

“An athlete’s risk of having a first-time noncontact ACL injury is independently influenced by level of competition, the participant’s sex, and type of sport they participate in, and there are no interactions between their effects. Female college athletes have the highest risk of having a first-time noncontact ACL injury among the groups studied,” Dr. Beynnon and colleagues stated.

Joost van Oss, an artist, was chopping wood years ago when he injured the middle knuckle on his right hand. The intense pain and swelling that followed the accident forced him to give up activities he enjoyed, such as sailing and cooking. This mishap also nearly ended his career as a sculptor and painter. He turned to David A. Kulber, MD, FACS, Clinical Chief and Director of the Cedars-Sinai Center for Plastic and Reconstructive Surgery in Los Angeles, California.

Dr. Kulber performed surgery on van Oss by using knee meniscus from a cadaver to reconstruct van Oss’ finger joint, which is a departure from the conventional technique of inserting a silicone implant into a joint.

According to Dr. Kulber, silicone implants are imperfect because they can become infected or break over time, leaving patients with lasting pain or in need of follow-up surgeries. Because the meniscus is malleable, it fits neatly into the joint, merging into the finger as new blood flows through it, Dr. Kulber said.

The patient regained mobility in his finger and just nine months after surgery he can now carry-on with the activities that he once did, all without pain. “You don’t realize what you’re missing when you have pain,” van Oss said. “Once it’s gone, all of the possibilities that were once there show up again.”

Dr. Kulber pioneered joint reconstruction with cadaver meniscus in the hope of achieving better outcomes for patients like van Oss who suffer from damaged finger joints or arthritis. “This is a very exciting approach to a problem that has defied reliable solutions,” said Dr. Kulber. “It’s a promising option because the meniscus becomes part of the finger.”

Joost van Oss, an artist, was chopping wood years ago when he injured the middle knuckle on his right hand. The intense pain and swelling that followed the accident forced him to give up activities he enjoyed, such as sailing and cooking. This mishap also nearly ended his career as a sculptor and painter. He turned to David A. Kulber, MD, FACS, Clinical Chief and Director of the Cedars-Sinai Center for Plastic and Reconstructive Surgery in Los Angeles, California.

Dr. Kulber performed surgery on van Oss by using knee meniscus from a cadaver to reconstruct van Oss’ finger joint, which is a departure from the conventional technique of inserting a silicone implant into a joint.

According to Dr. Kulber, silicone implants are imperfect because they can become infected or break over time, leaving patients with lasting pain or in need of follow-up surgeries. Because the meniscus is malleable, it fits neatly into the joint, merging into the finger as new blood flows through it, Dr. Kulber said.

The patient regained mobility in his finger and just nine months after surgery he can now carry-on with the activities that he once did, all without pain. “You don’t realize what you’re missing when you have pain,” van Oss said. “Once it’s gone, all of the possibilities that were once there show up again.”

Dr. Kulber pioneered joint reconstruction with cadaver meniscus in the hope of achieving better outcomes for patients like van Oss who suffer from damaged finger joints or arthritis. “This is a very exciting approach to a problem that has defied reliable solutions,” said Dr. Kulber. “It’s a promising option because the meniscus becomes part of the finger.”

Joost van Oss, an artist, was chopping wood years ago when he injured the middle knuckle on his right hand. The intense pain and swelling that followed the accident forced him to give up activities he enjoyed, such as sailing and cooking. This mishap also nearly ended his career as a sculptor and painter. He turned to David A. Kulber, MD, FACS, Clinical Chief and Director of the Cedars-Sinai Center for Plastic and Reconstructive Surgery in Los Angeles, California.

Dr. Kulber performed surgery on van Oss by using knee meniscus from a cadaver to reconstruct van Oss’ finger joint, which is a departure from the conventional technique of inserting a silicone implant into a joint.

According to Dr. Kulber, silicone implants are imperfect because they can become infected or break over time, leaving patients with lasting pain or in need of follow-up surgeries. Because the meniscus is malleable, it fits neatly into the joint, merging into the finger as new blood flows through it, Dr. Kulber said.

The patient regained mobility in his finger and just nine months after surgery he can now carry-on with the activities that he once did, all without pain. “You don’t realize what you’re missing when you have pain,” van Oss said. “Once it’s gone, all of the possibilities that were once there show up again.”

Dr. Kulber pioneered joint reconstruction with cadaver meniscus in the hope of achieving better outcomes for patients like van Oss who suffer from damaged finger joints or arthritis. “This is a very exciting approach to a problem that has defied reliable solutions,” said Dr. Kulber. “It’s a promising option because the meniscus becomes part of the finger.”

In patients older than 50 with moderate or severe chronic knee pain, neither laser nor needle acupuncture conferred benefit over sham for pain or function, according to a study published in the October 1 issue of JAMA.

Rana S. Hinman, PhD, from the University of Melbourne in Australia, and colleagues randomly assigned 282 patients (50 or older) with chronic knee pain to no acupuncture (control group, n = 71) or needle (n = 70), laser (n = 71), or sham laser (n = 70) acupuncture. Treatments were delivered for 12 weeks. Participants and acupuncturists were blinded to laser and sham laser acupuncture. Control participants were unaware of the trial.

Primary outcomes were average knee pain (numeric rating scale, 0 [no pain] to 10 [worst pain possible]; minimal clinically important difference [MCID], 1.8 units) and physical function (Western Ontario and McMaster Universities Osteoarthritis Index, 0 [no difficulty] to 68 [extreme difficulty]; MCID, 6 units) at 12 weeks.

Secondary outcomes included other pain and function measures, quality of life, global change, and one-year follow-up. Analyses were by intention-to-treat using multiple imputations for missing outcome data.

There were no significant differences in primary outcomes between active and sham acupuncture at 12 weeks or one year. Both needle and laser acupuncture resulted in modest improvements in pain compared with control at 12 weeks that were not maintained at one year. Needle acupuncture improved physical function at 12 weeks compared with control but was not different from sham acupuncture and was not maintained at one year. There were no differences for most secondary outcomes and no serious adverse events.

The authors noted that incidental factors such as treatment setting, patient expectations and attitudes (such as optimism), acupuncturist's confidence in treatment, and patient and acupuncturist interaction may influence outcomes.

"In our study, benefits of acupuncture were exclusively attributed to incidental effects, given the lack of significant differences between active acupuncture and sham treatment. Continuous subjective measures, such as pain and self-reported physical function, as used in our study, are particularly subject to placebo responses,” stated investigators. "In patients older than 50 years with moderate or severe chronic knee pain, neither laser nor needle acupuncture conferred benefit over sham for pain or function. Our findings do not support acupuncture for these patients."

In patients older than 50 with moderate or severe chronic knee pain, neither laser nor needle acupuncture conferred benefit over sham for pain or function, according to a study published in the October 1 issue of JAMA.

Rana S. Hinman, PhD, from the University of Melbourne in Australia, and colleagues randomly assigned 282 patients (50 or older) with chronic knee pain to no acupuncture (control group, n = 71) or needle (n = 70), laser (n = 71), or sham laser (n = 70) acupuncture. Treatments were delivered for 12 weeks. Participants and acupuncturists were blinded to laser and sham laser acupuncture. Control participants were unaware of the trial.

Primary outcomes were average knee pain (numeric rating scale, 0 [no pain] to 10 [worst pain possible]; minimal clinically important difference [MCID], 1.8 units) and physical function (Western Ontario and McMaster Universities Osteoarthritis Index, 0 [no difficulty] to 68 [extreme difficulty]; MCID, 6 units) at 12 weeks.

Secondary outcomes included other pain and function measures, quality of life, global change, and one-year follow-up. Analyses were by intention-to-treat using multiple imputations for missing outcome data.

There were no significant differences in primary outcomes between active and sham acupuncture at 12 weeks or one year. Both needle and laser acupuncture resulted in modest improvements in pain compared with control at 12 weeks that were not maintained at one year. Needle acupuncture improved physical function at 12 weeks compared with control but was not different from sham acupuncture and was not maintained at one year. There were no differences for most secondary outcomes and no serious adverse events.

The authors noted that incidental factors such as treatment setting, patient expectations and attitudes (such as optimism), acupuncturist's confidence in treatment, and patient and acupuncturist interaction may influence outcomes.

"In our study, benefits of acupuncture were exclusively attributed to incidental effects, given the lack of significant differences between active acupuncture and sham treatment. Continuous subjective measures, such as pain and self-reported physical function, as used in our study, are particularly subject to placebo responses,” stated investigators. "In patients older than 50 years with moderate or severe chronic knee pain, neither laser nor needle acupuncture conferred benefit over sham for pain or function. Our findings do not support acupuncture for these patients."

In patients older than 50 with moderate or severe chronic knee pain, neither laser nor needle acupuncture conferred benefit over sham for pain or function, according to a study published in the October 1 issue of JAMA.

Rana S. Hinman, PhD, from the University of Melbourne in Australia, and colleagues randomly assigned 282 patients (50 or older) with chronic knee pain to no acupuncture (control group, n = 71) or needle (n = 70), laser (n = 71), or sham laser (n = 70) acupuncture. Treatments were delivered for 12 weeks. Participants and acupuncturists were blinded to laser and sham laser acupuncture. Control participants were unaware of the trial.

Primary outcomes were average knee pain (numeric rating scale, 0 [no pain] to 10 [worst pain possible]; minimal clinically important difference [MCID], 1.8 units) and physical function (Western Ontario and McMaster Universities Osteoarthritis Index, 0 [no difficulty] to 68 [extreme difficulty]; MCID, 6 units) at 12 weeks.

Secondary outcomes included other pain and function measures, quality of life, global change, and one-year follow-up. Analyses were by intention-to-treat using multiple imputations for missing outcome data.

There were no significant differences in primary outcomes between active and sham acupuncture at 12 weeks or one year. Both needle and laser acupuncture resulted in modest improvements in pain compared with control at 12 weeks that were not maintained at one year. Needle acupuncture improved physical function at 12 weeks compared with control but was not different from sham acupuncture and was not maintained at one year. There were no differences for most secondary outcomes and no serious adverse events.

The authors noted that incidental factors such as treatment setting, patient expectations and attitudes (such as optimism), acupuncturist's confidence in treatment, and patient and acupuncturist interaction may influence outcomes.

"In our study, benefits of acupuncture were exclusively attributed to incidental effects, given the lack of significant differences between active acupuncture and sham treatment. Continuous subjective measures, such as pain and self-reported physical function, as used in our study, are particularly subject to placebo responses,” stated investigators. "In patients older than 50 years with moderate or severe chronic knee pain, neither laser nor needle acupuncture conferred benefit over sham for pain or function. Our findings do not support acupuncture for these patients."