Key clinical point: The risk for grade 3-4 (G3-4) neutropenia and febrile neutropenia (FN) is higher with FOLFOXIRI/bevacizumab vs doublets/bevacizumab as first-line treatment of metastatic colorectal cancer (mCRC), with the risk being higher in older females, who may benefit with prophylactic use of granulocyte colony-stimulating factor.

Major finding: The incidence of G3-4 neutropenia (51% vs 21%; P < .001), FN (8% vs 4%; P = .02), and high-risk FN (3% vs 1%; P = .015) was significantly higher with FOLFOXIRI/bevacizumab vs doublet/bevacizumab, mostly during the first cycles. The risk for G3-4 neutropenia was significantly higher among older patients (P = .01) and females (P < .001).

Study details: This pooled analysis included 1,155 patients with untreated mCRC from TRIBE1 and TRIBE 2 phase 3 trials, of which 568 patients received FOLFOXIRI/bevacizumab and 587 received doublet/bevacizumab (FOLFIRI/bevacizumab; n=254 or FOLFOX/bevacizumab; n=335).

Disclosures: This study was supported by GONO and ARCO Foundations. Some of the authors declared receiving honoraria, travel grant, research funding, speakers’ bureau, and/or consulting or advisory role for various sources.

Source: Rossini D et al. ESMO Open. 2021 Oct 21. doi: 10.1016/j.esmoop.2021.100293.

Key clinical point: The risk for grade 3-4 (G3-4) neutropenia and febrile neutropenia (FN) is higher with FOLFOXIRI/bevacizumab vs doublets/bevacizumab as first-line treatment of metastatic colorectal cancer (mCRC), with the risk being higher in older females, who may benefit with prophylactic use of granulocyte colony-stimulating factor.

Major finding: The incidence of G3-4 neutropenia (51% vs 21%; P < .001), FN (8% vs 4%; P = .02), and high-risk FN (3% vs 1%; P = .015) was significantly higher with FOLFOXIRI/bevacizumab vs doublet/bevacizumab, mostly during the first cycles. The risk for G3-4 neutropenia was significantly higher among older patients (P = .01) and females (P < .001).

Study details: This pooled analysis included 1,155 patients with untreated mCRC from TRIBE1 and TRIBE 2 phase 3 trials, of which 568 patients received FOLFOXIRI/bevacizumab and 587 received doublet/bevacizumab (FOLFIRI/bevacizumab; n=254 or FOLFOX/bevacizumab; n=335).

Disclosures: This study was supported by GONO and ARCO Foundations. Some of the authors declared receiving honoraria, travel grant, research funding, speakers’ bureau, and/or consulting or advisory role for various sources.

Source: Rossini D et al. ESMO Open. 2021 Oct 21. doi: 10.1016/j.esmoop.2021.100293.

Key clinical point: The risk for grade 3-4 (G3-4) neutropenia and febrile neutropenia (FN) is higher with FOLFOXIRI/bevacizumab vs doublets/bevacizumab as first-line treatment of metastatic colorectal cancer (mCRC), with the risk being higher in older females, who may benefit with prophylactic use of granulocyte colony-stimulating factor.

Major finding: The incidence of G3-4 neutropenia (51% vs 21%; P < .001), FN (8% vs 4%; P = .02), and high-risk FN (3% vs 1%; P = .015) was significantly higher with FOLFOXIRI/bevacizumab vs doublet/bevacizumab, mostly during the first cycles. The risk for G3-4 neutropenia was significantly higher among older patients (P = .01) and females (P < .001).

Study details: This pooled analysis included 1,155 patients with untreated mCRC from TRIBE1 and TRIBE 2 phase 3 trials, of which 568 patients received FOLFOXIRI/bevacizumab and 587 received doublet/bevacizumab (FOLFIRI/bevacizumab; n=254 or FOLFOX/bevacizumab; n=335).

Disclosures: This study was supported by GONO and ARCO Foundations. Some of the authors declared receiving honoraria, travel grant, research funding, speakers’ bureau, and/or consulting or advisory role for various sources.

Source: Rossini D et al. ESMO Open. 2021 Oct 21. doi: 10.1016/j.esmoop.2021.100293.

Key clinical point: Women who underwent adenoma removal appear to be at a higher risk for colorectal cancer (CRC) incidence and CRC-related deaths, highlighting the need for sex-specific surveillance after adenoma removal.

Major finding: Compared with general population, CRC incidence was higher in women (standardized incidence ratios [SIR], 1.64; 95% CI, 1.54-1.74) than in men (SIR, 1.12; 95% CI, 1.05-1.19) who had adenomas removed. CRC mortality increased in women (standardized incidence-based mortality ratios [SMR], 1.13; 95% CI, 1.02-1.26) and reduced in men (SMR, 0.79; 95% CI, 0.71-0.89) who underwent adenoma removal compared with general population.

Study details: Findings are from a cohort study of 40,293 individuals who had their adenomas removed.

Disclosures: This work was supported by grants from Norwegian Research Council and Norwegian Cancer Society. The authors declared no conflict of interests.

Source: Jodal HC et al. Aliment Pharmacol Ther. 2021 Oct 30. doi: 10.1111/apt.16686.

Key clinical point: Women who underwent adenoma removal appear to be at a higher risk for colorectal cancer (CRC) incidence and CRC-related deaths, highlighting the need for sex-specific surveillance after adenoma removal.

Major finding: Compared with general population, CRC incidence was higher in women (standardized incidence ratios [SIR], 1.64; 95% CI, 1.54-1.74) than in men (SIR, 1.12; 95% CI, 1.05-1.19) who had adenomas removed. CRC mortality increased in women (standardized incidence-based mortality ratios [SMR], 1.13; 95% CI, 1.02-1.26) and reduced in men (SMR, 0.79; 95% CI, 0.71-0.89) who underwent adenoma removal compared with general population.

Study details: Findings are from a cohort study of 40,293 individuals who had their adenomas removed.

Disclosures: This work was supported by grants from Norwegian Research Council and Norwegian Cancer Society. The authors declared no conflict of interests.

Source: Jodal HC et al. Aliment Pharmacol Ther. 2021 Oct 30. doi: 10.1111/apt.16686.

Key clinical point: Women who underwent adenoma removal appear to be at a higher risk for colorectal cancer (CRC) incidence and CRC-related deaths, highlighting the need for sex-specific surveillance after adenoma removal.

Major finding: Compared with general population, CRC incidence was higher in women (standardized incidence ratios [SIR], 1.64; 95% CI, 1.54-1.74) than in men (SIR, 1.12; 95% CI, 1.05-1.19) who had adenomas removed. CRC mortality increased in women (standardized incidence-based mortality ratios [SMR], 1.13; 95% CI, 1.02-1.26) and reduced in men (SMR, 0.79; 95% CI, 0.71-0.89) who underwent adenoma removal compared with general population.

Study details: Findings are from a cohort study of 40,293 individuals who had their adenomas removed.

Disclosures: This work was supported by grants from Norwegian Research Council and Norwegian Cancer Society. The authors declared no conflict of interests.

Source: Jodal HC et al. Aliment Pharmacol Ther. 2021 Oct 30. doi: 10.1111/apt.16686.

Key clinical point: Pre-operative sarcopenia predicted shorter disease-free survival (DFS), overall survival (OS), and recurrence of the liver in patients with lower advanced rectal cancer receiving preoperative adjuvant chemoradiotherapy (CRT).

Major finding: Post-CRT sarcopenia was an independent prognostic factor for shorter DFS (hazard ratio [HR], 2.01; P = .049), OS (HR, 1.76; P = .036), and recurrence in the liver (HR, 3.01; P = .025).

Study details: Findings are from a retrospective analysis of 234 patients with cT3-T4 anyN M0 lower rectal cancer who underwent CRT (5-fluorouracil-based oral chemotherapy and long course radiation) followed by radical surgery.

Disclosures: This study was supported by Japan Society for the Promotion of Science and Japan Agency for Medical Research and Development. The authors declared no conflict of interests.

Source: Abe S et al. Int J Clin Oncol. 2021 Nov 6. doi: 10.1007/s10147-021-02062-z.

Key clinical point: Pre-operative sarcopenia predicted shorter disease-free survival (DFS), overall survival (OS), and recurrence of the liver in patients with lower advanced rectal cancer receiving preoperative adjuvant chemoradiotherapy (CRT).

Major finding: Post-CRT sarcopenia was an independent prognostic factor for shorter DFS (hazard ratio [HR], 2.01; P = .049), OS (HR, 1.76; P = .036), and recurrence in the liver (HR, 3.01; P = .025).

Study details: Findings are from a retrospective analysis of 234 patients with cT3-T4 anyN M0 lower rectal cancer who underwent CRT (5-fluorouracil-based oral chemotherapy and long course radiation) followed by radical surgery.

Disclosures: This study was supported by Japan Society for the Promotion of Science and Japan Agency for Medical Research and Development. The authors declared no conflict of interests.

Source: Abe S et al. Int J Clin Oncol. 2021 Nov 6. doi: 10.1007/s10147-021-02062-z.

Key clinical point: Pre-operative sarcopenia predicted shorter disease-free survival (DFS), overall survival (OS), and recurrence of the liver in patients with lower advanced rectal cancer receiving preoperative adjuvant chemoradiotherapy (CRT).

Major finding: Post-CRT sarcopenia was an independent prognostic factor for shorter DFS (hazard ratio [HR], 2.01; P = .049), OS (HR, 1.76; P = .036), and recurrence in the liver (HR, 3.01; P = .025).

Study details: Findings are from a retrospective analysis of 234 patients with cT3-T4 anyN M0 lower rectal cancer who underwent CRT (5-fluorouracil-based oral chemotherapy and long course radiation) followed by radical surgery.

Disclosures: This study was supported by Japan Society for the Promotion of Science and Japan Agency for Medical Research and Development. The authors declared no conflict of interests.

Source: Abe S et al. Int J Clin Oncol. 2021 Nov 6. doi: 10.1007/s10147-021-02062-z.

Key clinical point: The combination of immune checkpoint inhibitors (ICIs) with regorafenib showed promising efficacy in chemotherapy-refractory microsatellite stable (MSS) colorectal cancer (CRC).

Major finding: Overall, 5% and 45% of patients achieved partial response and stable disease as the best response, respectively. The median overall survival and progression-free survival (PFS) were 17.3 months (95% CI, 11.3-not reached) and 3.1 months (95% CI, 2.3-4.2), respectively, with 13% of patients achieving PFS of ≥6 months. Grade 3 or higher treatment-related adverse events were reported by 19% of patients.

Study details: Findings are from a retrospective analysis of 84 patients with chemotherapy-refractory advanced or metastatic MSS CRC who received at least 1 dose of ICIs combined with regorafenib.

Disclosures: This work was supported by grants from the National Natural Science Foundation of China and CAMS Innovation Fund for Medical Sciences. The authors declare no conflict of interests.

Source: Yang K et al. Cancer Immunol Immunother. 2021 Oct 24. doi: 10.1007/s00262-021-03083-3.

Key clinical point: The combination of immune checkpoint inhibitors (ICIs) with regorafenib showed promising efficacy in chemotherapy-refractory microsatellite stable (MSS) colorectal cancer (CRC).

Major finding: Overall, 5% and 45% of patients achieved partial response and stable disease as the best response, respectively. The median overall survival and progression-free survival (PFS) were 17.3 months (95% CI, 11.3-not reached) and 3.1 months (95% CI, 2.3-4.2), respectively, with 13% of patients achieving PFS of ≥6 months. Grade 3 or higher treatment-related adverse events were reported by 19% of patients.

Study details: Findings are from a retrospective analysis of 84 patients with chemotherapy-refractory advanced or metastatic MSS CRC who received at least 1 dose of ICIs combined with regorafenib.

Disclosures: This work was supported by grants from the National Natural Science Foundation of China and CAMS Innovation Fund for Medical Sciences. The authors declare no conflict of interests.

Source: Yang K et al. Cancer Immunol Immunother. 2021 Oct 24. doi: 10.1007/s00262-021-03083-3.

Key clinical point: The combination of immune checkpoint inhibitors (ICIs) with regorafenib showed promising efficacy in chemotherapy-refractory microsatellite stable (MSS) colorectal cancer (CRC).

Major finding: Overall, 5% and 45% of patients achieved partial response and stable disease as the best response, respectively. The median overall survival and progression-free survival (PFS) were 17.3 months (95% CI, 11.3-not reached) and 3.1 months (95% CI, 2.3-4.2), respectively, with 13% of patients achieving PFS of ≥6 months. Grade 3 or higher treatment-related adverse events were reported by 19% of patients.

Study details: Findings are from a retrospective analysis of 84 patients with chemotherapy-refractory advanced or metastatic MSS CRC who received at least 1 dose of ICIs combined with regorafenib.

Disclosures: This work was supported by grants from the National Natural Science Foundation of China and CAMS Innovation Fund for Medical Sciences. The authors declare no conflict of interests.

Source: Yang K et al. Cancer Immunol Immunother. 2021 Oct 24. doi: 10.1007/s00262-021-03083-3.

Key clinical point: Management of colorectal cancer (CRC) and synchronous liver metastases with staged liver-first or bowel-first routes or synchronous combined liver and bowel surgery, all with contemporary systemic chemotherapy, led to similar perioperative complications and oncological outcomes.

Major finding: Postoperative complications (P = .66), total critical care occupancy (P = .92) and mean total inpatient stay (P = .91) were similar between synchronous and staged management pathways. Overall, 35% of patients were disease-free at 12 months, with no difference between groups (P = .448).

Study details: Findings are from CoSMIC, a prospective inception cohort study including 125 patients with CRC and synchronous liver metastases.

Disclosures: AKC Chan was supported by a grant from the Dickinson Trust.

Source: Chan AKC et al. Ann Surg Oncol. 2021 Oct 30. doi: 10.1245/s10434-021-11017-7.

Key clinical point: Management of colorectal cancer (CRC) and synchronous liver metastases with staged liver-first or bowel-first routes or synchronous combined liver and bowel surgery, all with contemporary systemic chemotherapy, led to similar perioperative complications and oncological outcomes.

Major finding: Postoperative complications (P = .66), total critical care occupancy (P = .92) and mean total inpatient stay (P = .91) were similar between synchronous and staged management pathways. Overall, 35% of patients were disease-free at 12 months, with no difference between groups (P = .448).

Study details: Findings are from CoSMIC, a prospective inception cohort study including 125 patients with CRC and synchronous liver metastases.

Disclosures: AKC Chan was supported by a grant from the Dickinson Trust.

Source: Chan AKC et al. Ann Surg Oncol. 2021 Oct 30. doi: 10.1245/s10434-021-11017-7.

Key clinical point: Management of colorectal cancer (CRC) and synchronous liver metastases with staged liver-first or bowel-first routes or synchronous combined liver and bowel surgery, all with contemporary systemic chemotherapy, led to similar perioperative complications and oncological outcomes.

Major finding: Postoperative complications (P = .66), total critical care occupancy (P = .92) and mean total inpatient stay (P = .91) were similar between synchronous and staged management pathways. Overall, 35% of patients were disease-free at 12 months, with no difference between groups (P = .448).

Study details: Findings are from CoSMIC, a prospective inception cohort study including 125 patients with CRC and synchronous liver metastases.

Disclosures: AKC Chan was supported by a grant from the Dickinson Trust.

Source: Chan AKC et al. Ann Surg Oncol. 2021 Oct 30. doi: 10.1245/s10434-021-11017-7.

Key clinical point: Short-course radiotherapy (SCRT) combined with subsequent capecitabine plus oxaliplatin (CAPOX) and camrelizumab followed by delayed surgery showed remarkable pathological complete response (pCR) with manageable toxicity in patients with locally advanced rectal cancer (LARC).

Major finding: Overall, 48.1% of patients, including 46.2% patients with proficient mismatch repair tumors and 100% of patients with deficient mismatch repair tumors, achieved pCR. All immune-related adverse events were of grade 1-2, with the most common being reactive cutaneous capillary endothelial proliferation (81.5%).

Study details: Findings are from a single-arm, phase 2 trial including 30 patients with LARC, of which 27 received preoperative SCRT combined with subsequent CAPOX and camrelizumab followed by radical surgery after 1 week.

Disclosures: This work was supported by the Ministry of Science and Technology of China, 2018 National Natural Science Foundation of China, and Jiangsu Hengrui Pharmaceuticals Co., Ltd. T Zhang declared receiving research funding from and Z Hou and C Ma declared being employees of Jiangsu Hengrui Pharmaceuticals Co., Ltd.

Source: Lin Z et al. J Immunother Cancer. 2021 Nov 1. doi: 10.1136/jitc-2021-003554.

Key clinical point: Short-course radiotherapy (SCRT) combined with subsequent capecitabine plus oxaliplatin (CAPOX) and camrelizumab followed by delayed surgery showed remarkable pathological complete response (pCR) with manageable toxicity in patients with locally advanced rectal cancer (LARC).

Major finding: Overall, 48.1% of patients, including 46.2% patients with proficient mismatch repair tumors and 100% of patients with deficient mismatch repair tumors, achieved pCR. All immune-related adverse events were of grade 1-2, with the most common being reactive cutaneous capillary endothelial proliferation (81.5%).

Study details: Findings are from a single-arm, phase 2 trial including 30 patients with LARC, of which 27 received preoperative SCRT combined with subsequent CAPOX and camrelizumab followed by radical surgery after 1 week.

Disclosures: This work was supported by the Ministry of Science and Technology of China, 2018 National Natural Science Foundation of China, and Jiangsu Hengrui Pharmaceuticals Co., Ltd. T Zhang declared receiving research funding from and Z Hou and C Ma declared being employees of Jiangsu Hengrui Pharmaceuticals Co., Ltd.

Source: Lin Z et al. J Immunother Cancer. 2021 Nov 1. doi: 10.1136/jitc-2021-003554.

Key clinical point: Short-course radiotherapy (SCRT) combined with subsequent capecitabine plus oxaliplatin (CAPOX) and camrelizumab followed by delayed surgery showed remarkable pathological complete response (pCR) with manageable toxicity in patients with locally advanced rectal cancer (LARC).

Major finding: Overall, 48.1% of patients, including 46.2% patients with proficient mismatch repair tumors and 100% of patients with deficient mismatch repair tumors, achieved pCR. All immune-related adverse events were of grade 1-2, with the most common being reactive cutaneous capillary endothelial proliferation (81.5%).

Study details: Findings are from a single-arm, phase 2 trial including 30 patients with LARC, of which 27 received preoperative SCRT combined with subsequent CAPOX and camrelizumab followed by radical surgery after 1 week.

Disclosures: This work was supported by the Ministry of Science and Technology of China, 2018 National Natural Science Foundation of China, and Jiangsu Hengrui Pharmaceuticals Co., Ltd. T Zhang declared receiving research funding from and Z Hou and C Ma declared being employees of Jiangsu Hengrui Pharmaceuticals Co., Ltd.

Source: Lin Z et al. J Immunother Cancer. 2021 Nov 1. doi: 10.1136/jitc-2021-003554.

Key clinical point: Higher consumption of preserved vegetables was associated with an increased prevalence of colorectal polyps as a precursor lesion of colorectal cancer (CRC), particularly small polyps in a population at high risk for CRC.

Major finding: Consumption of preserved vegetables was associated with an 18% higher prevalence of colorectal polyps (adjusted odds ratio highest vs lowest quartile [aOR_{Q4 vs Q1}], 1.18; P trend = .02) and 17% higher prevalence of small polyps (aOR_{Q4 vs Q1}, 1.17; P trend = .03).

Study details: Findings are from a survey analysis of 6,783 respondents from Lanxi Pre-colorectal Cancer Cohort who were at high risk for CRC.

Disclosures: This study was supported by Lanxi Municipal Government funds. The authors declared no conflict of interests.

Source: Wu F et al. Eur J Nutr. 2021 Nov 8. doi: 10.1007/s00394-021-02719-5.

Key clinical point: Higher consumption of preserved vegetables was associated with an increased prevalence of colorectal polyps as a precursor lesion of colorectal cancer (CRC), particularly small polyps in a population at high risk for CRC.

Major finding: Consumption of preserved vegetables was associated with an 18% higher prevalence of colorectal polyps (adjusted odds ratio highest vs lowest quartile [aOR_{Q4 vs Q1}], 1.18; P trend = .02) and 17% higher prevalence of small polyps (aOR_{Q4 vs Q1}, 1.17; P trend = .03).

Study details: Findings are from a survey analysis of 6,783 respondents from Lanxi Pre-colorectal Cancer Cohort who were at high risk for CRC.

Disclosures: This study was supported by Lanxi Municipal Government funds. The authors declared no conflict of interests.

Source: Wu F et al. Eur J Nutr. 2021 Nov 8. doi: 10.1007/s00394-021-02719-5.

Key clinical point: Higher consumption of preserved vegetables was associated with an increased prevalence of colorectal polyps as a precursor lesion of colorectal cancer (CRC), particularly small polyps in a population at high risk for CRC.

Major finding: Consumption of preserved vegetables was associated with an 18% higher prevalence of colorectal polyps (adjusted odds ratio highest vs lowest quartile [aOR_{Q4 vs Q1}], 1.18; P trend = .02) and 17% higher prevalence of small polyps (aOR_{Q4 vs Q1}, 1.17; P trend = .03).

Study details: Findings are from a survey analysis of 6,783 respondents from Lanxi Pre-colorectal Cancer Cohort who were at high risk for CRC.

Disclosures: This study was supported by Lanxi Municipal Government funds. The authors declared no conflict of interests.

Source: Wu F et al. Eur J Nutr. 2021 Nov 8. doi: 10.1007/s00394-021-02719-5.

Key clinical point: Patients with stage III early-onset colorectal cancer (EO-CRC) experienced more frequent disease recurrence and cancer-specific mortality than patients with late-onset CRC (LO-CRC), suggesting more aggressive disease biology.

Major finding: Despite a higher likelihood of receiving more aggressive treatment and completing planned 6-month therapy duration (P < .001), patients with stage III EO-CRC vs LO-CRC had a significantly lower 3-year relapse-free rate (hazard ratio [HR], 1.21; P = .003) and higher 5-year cancer-specific mortality rate (HR, 1.20; P = .03).

Study details: This was a pooled analysis of 16,349 patients with CRC from 6 clinical trials of adjuvant chemotherapy including 1,564 patients with EO-CRC and 14,785 with LO-CRC.

Disclosures: This study was supported by European Organisation for Research and Treatment of Cancer, Japanese Foundation for Multidisciplinary Treatment of Cancer, and others. The authors declared receiving honoraria, research funding, consulting or advisory role, travel, accommodation expenses, stock, and other ownership interests from various sources.

Source: Fontana E et al. J Clin Oncol. 2021 Nov 9. doi: 10.1200/JCO.21.02008.

Key clinical point: Patients with stage III early-onset colorectal cancer (EO-CRC) experienced more frequent disease recurrence and cancer-specific mortality than patients with late-onset CRC (LO-CRC), suggesting more aggressive disease biology.

Major finding: Despite a higher likelihood of receiving more aggressive treatment and completing planned 6-month therapy duration (P < .001), patients with stage III EO-CRC vs LO-CRC had a significantly lower 3-year relapse-free rate (hazard ratio [HR], 1.21; P = .003) and higher 5-year cancer-specific mortality rate (HR, 1.20; P = .03).

Study details: This was a pooled analysis of 16,349 patients with CRC from 6 clinical trials of adjuvant chemotherapy including 1,564 patients with EO-CRC and 14,785 with LO-CRC.

Disclosures: This study was supported by European Organisation for Research and Treatment of Cancer, Japanese Foundation for Multidisciplinary Treatment of Cancer, and others. The authors declared receiving honoraria, research funding, consulting or advisory role, travel, accommodation expenses, stock, and other ownership interests from various sources.

Source: Fontana E et al. J Clin Oncol. 2021 Nov 9. doi: 10.1200/JCO.21.02008.

Key clinical point: Patients with stage III early-onset colorectal cancer (EO-CRC) experienced more frequent disease recurrence and cancer-specific mortality than patients with late-onset CRC (LO-CRC), suggesting more aggressive disease biology.

Major finding: Despite a higher likelihood of receiving more aggressive treatment and completing planned 6-month therapy duration (P < .001), patients with stage III EO-CRC vs LO-CRC had a significantly lower 3-year relapse-free rate (hazard ratio [HR], 1.21; P = .003) and higher 5-year cancer-specific mortality rate (HR, 1.20; P = .03).

Study details: This was a pooled analysis of 16,349 patients with CRC from 6 clinical trials of adjuvant chemotherapy including 1,564 patients with EO-CRC and 14,785 with LO-CRC.

Disclosures: This study was supported by European Organisation for Research and Treatment of Cancer, Japanese Foundation for Multidisciplinary Treatment of Cancer, and others. The authors declared receiving honoraria, research funding, consulting or advisory role, travel, accommodation expenses, stock, and other ownership interests from various sources.

Source: Fontana E et al. J Clin Oncol. 2021 Nov 9. doi: 10.1200/JCO.21.02008.

Key clinical point: Simultaneous resection of primary colonic tumor and hepatic arterial infusion pump (HAIP) implantation are safe in patients with colon cancer and synchronous liver metastases.

Major finding: Grade 3-4 complications were similar between patients who underwent simultaneous colectomy and HAIP placement vs prior colectomy (P = .872), whereas grade 1-2 complications (36.8% vs 19.0%; P < .001) and the rate for surgical site infection (25.6% vs14.7%; P = .022) were significantly higher with simultaneous colectomy and HAIP placement. The median time from pump placement to the start of HAIP chemotherapy was not different between the groups (P = .924).

Study details: Findings are from a retrospective analysis of 398 patients with colon cancer and synchronous liver metastases who underwent resection of the primary colon tumor either simultaneous with HAIP placement (n=258) or prior to HAIP placement (n=116).

Disclosures: This study was partly supported by National Cancer Institute. J Garcia-Aguilar declared receiving honoraria from Johnson & Johnson, Medtronic, and Intuitive Inc.

Source: Verheij FS et al. Ann Surg Oncol. 2021 Nov 9. doi: 10.1245/s10434-021-11029-3.

Key clinical point: Simultaneous resection of primary colonic tumor and hepatic arterial infusion pump (HAIP) implantation are safe in patients with colon cancer and synchronous liver metastases.

Major finding: Grade 3-4 complications were similar between patients who underwent simultaneous colectomy and HAIP placement vs prior colectomy (P = .872), whereas grade 1-2 complications (36.8% vs 19.0%; P < .001) and the rate for surgical site infection (25.6% vs14.7%; P = .022) were significantly higher with simultaneous colectomy and HAIP placement. The median time from pump placement to the start of HAIP chemotherapy was not different between the groups (P = .924).

Study details: Findings are from a retrospective analysis of 398 patients with colon cancer and synchronous liver metastases who underwent resection of the primary colon tumor either simultaneous with HAIP placement (n=258) or prior to HAIP placement (n=116).

Disclosures: This study was partly supported by National Cancer Institute. J Garcia-Aguilar declared receiving honoraria from Johnson & Johnson, Medtronic, and Intuitive Inc.

Source: Verheij FS et al. Ann Surg Oncol. 2021 Nov 9. doi: 10.1245/s10434-021-11029-3.

Key clinical point: Simultaneous resection of primary colonic tumor and hepatic arterial infusion pump (HAIP) implantation are safe in patients with colon cancer and synchronous liver metastases.

Major finding: Grade 3-4 complications were similar between patients who underwent simultaneous colectomy and HAIP placement vs prior colectomy (P = .872), whereas grade 1-2 complications (36.8% vs 19.0%; P < .001) and the rate for surgical site infection (25.6% vs14.7%; P = .022) were significantly higher with simultaneous colectomy and HAIP placement. The median time from pump placement to the start of HAIP chemotherapy was not different between the groups (P = .924).

Study details: Findings are from a retrospective analysis of 398 patients with colon cancer and synchronous liver metastases who underwent resection of the primary colon tumor either simultaneous with HAIP placement (n=258) or prior to HAIP placement (n=116).

Disclosures: This study was partly supported by National Cancer Institute. J Garcia-Aguilar declared receiving honoraria from Johnson & Johnson, Medtronic, and Intuitive Inc.

Source: Verheij FS et al. Ann Surg Oncol. 2021 Nov 9. doi: 10.1245/s10434-021-11029-3.

Key clinical point: A single flexible sigmoidoscopy (FS) at the age of 55-64 years substantially reduced the risk for colorectal cancer (CRC) incidence and CRC-related mortality, which was maintained up to 15 and 19 years, respectively.

Major finding: CRC incidence and CRC mortality reduced by 19% (rate ratio [RR], 0.81; 95% CI, 0.71-0.93) and 22% (RR, 0.78; 95% CI, 0.61-0.98), respectively, in the group that underwent FS vs usual care, with the reduction mainly driven by a reduced incidence of distal CRC (RR, 0.70; 95% CI, 0.59-0.84) and distal CRC mortality (RR, 0.69; 95% CI, 0.50-0.95).

Study details: Findings are from SCORE randomized control trial including 34,272 participants who expressed interest in having FS and were randomly assigned to FS (n=17,136) or usual care (n=17,136) groups.

Disclosures: The trial was supported by Italian Association for Cancer Research, Italian National Research Council, and others. C Semore declared receiving research funding, travel support, and paid/unpaid leadership or fiduciary role for various sources.

Source: Senore C et al. Ann Intern Med. 2021 Nov 9. doi: 10.7326/M21-0977. 

Key clinical point: A single flexible sigmoidoscopy (FS) at the age of 55-64 years substantially reduced the risk for colorectal cancer (CRC) incidence and CRC-related mortality, which was maintained up to 15 and 19 years, respectively.

Major finding: CRC incidence and CRC mortality reduced by 19% (rate ratio [RR], 0.81; 95% CI, 0.71-0.93) and 22% (RR, 0.78; 95% CI, 0.61-0.98), respectively, in the group that underwent FS vs usual care, with the reduction mainly driven by a reduced incidence of distal CRC (RR, 0.70; 95% CI, 0.59-0.84) and distal CRC mortality (RR, 0.69; 95% CI, 0.50-0.95).

Study details: Findings are from SCORE randomized control trial including 34,272 participants who expressed interest in having FS and were randomly assigned to FS (n=17,136) or usual care (n=17,136) groups.

Disclosures: The trial was supported by Italian Association for Cancer Research, Italian National Research Council, and others. C Semore declared receiving research funding, travel support, and paid/unpaid leadership or fiduciary role for various sources.

Source: Senore C et al. Ann Intern Med. 2021 Nov 9. doi: 10.7326/M21-0977. 

Key clinical point: A single flexible sigmoidoscopy (FS) at the age of 55-64 years substantially reduced the risk for colorectal cancer (CRC) incidence and CRC-related mortality, which was maintained up to 15 and 19 years, respectively.

Major finding: CRC incidence and CRC mortality reduced by 19% (rate ratio [RR], 0.81; 95% CI, 0.71-0.93) and 22% (RR, 0.78; 95% CI, 0.61-0.98), respectively, in the group that underwent FS vs usual care, with the reduction mainly driven by a reduced incidence of distal CRC (RR, 0.70; 95% CI, 0.59-0.84) and distal CRC mortality (RR, 0.69; 95% CI, 0.50-0.95).

Study details: Findings are from SCORE randomized control trial including 34,272 participants who expressed interest in having FS and were randomly assigned to FS (n=17,136) or usual care (n=17,136) groups.

Disclosures: The trial was supported by Italian Association for Cancer Research, Italian National Research Council, and others. C Semore declared receiving research funding, travel support, and paid/unpaid leadership or fiduciary role for various sources.

Source: Senore C et al. Ann Intern Med. 2021 Nov 9. doi: 10.7326/M21-0977.