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Key clinical point: An early severe postoperative inflammatory response increased the risk for recurrence in patients with colorectal cancer (CRC) who underwent curative surgery, with the recurrence hazard being early and persistently higher in patients with high vs low C-reactive protein (CRP) levels.
Major finding: High vs low CRP levels was a significant predictor of worse 5-year RFS (adjusted hazard ratio 2.21; P < .001) with the hazard function peak being higher and earlier in the high (peak rate 0.0142; peak months 5.6) vs low (peak rate 0.0073; peak months 8.4) CRP group.
Study details: The data come from a retrospective study including 422 patients with stage I-IV CRC who underwent curative surgery and were followed for 5 years after surgery.
Disclosures: This study did not report the source of funding. No conflicts of interest were declared.
Source: Nakamura Y et al. Impact of severe postoperative inflammatory response on recurrence after curative resection of colorectal cancer. Int J Colorectal Dis. 2022;37(11):2375-2386 (Oct 24). Doi: 10.1007/s00384-022-04271-y
Key clinical point: An early severe postoperative inflammatory response increased the risk for recurrence in patients with colorectal cancer (CRC) who underwent curative surgery, with the recurrence hazard being early and persistently higher in patients with high vs low C-reactive protein (CRP) levels.
Major finding: High vs low CRP levels was a significant predictor of worse 5-year RFS (adjusted hazard ratio 2.21; P < .001) with the hazard function peak being higher and earlier in the high (peak rate 0.0142; peak months 5.6) vs low (peak rate 0.0073; peak months 8.4) CRP group.
Study details: The data come from a retrospective study including 422 patients with stage I-IV CRC who underwent curative surgery and were followed for 5 years after surgery.
Disclosures: This study did not report the source of funding. No conflicts of interest were declared.
Source: Nakamura Y et al. Impact of severe postoperative inflammatory response on recurrence after curative resection of colorectal cancer. Int J Colorectal Dis. 2022;37(11):2375-2386 (Oct 24). Doi: 10.1007/s00384-022-04271-y
Key clinical point: An early severe postoperative inflammatory response increased the risk for recurrence in patients with colorectal cancer (CRC) who underwent curative surgery, with the recurrence hazard being early and persistently higher in patients with high vs low C-reactive protein (CRP) levels.
Major finding: High vs low CRP levels was a significant predictor of worse 5-year RFS (adjusted hazard ratio 2.21; P < .001) with the hazard function peak being higher and earlier in the high (peak rate 0.0142; peak months 5.6) vs low (peak rate 0.0073; peak months 8.4) CRP group.
Study details: The data come from a retrospective study including 422 patients with stage I-IV CRC who underwent curative surgery and were followed for 5 years after surgery.
Disclosures: This study did not report the source of funding. No conflicts of interest were declared.
Source: Nakamura Y et al. Impact of severe postoperative inflammatory response on recurrence after curative resection of colorectal cancer. Int J Colorectal Dis. 2022;37(11):2375-2386 (Oct 24). Doi: 10.1007/s00384-022-04271-y