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Key clinical point: Simultaneous vs delayed resection of synchronous liver metastasis (SLM) was associated with longer survival rates in patients with colorectal cancer (CRC) with KRAS wild-type tumors but not in those with KRAS sequence variation.
Major finding: Perioperative complications within 60 days of surgery were not significantly different in the simultaneous vs delayed resection group (P = .89), but simultaneous vs delayed resection was associated with better 5-year overall survival (hazard ratio [HR] 1.61; P < .001) and cancer-specific survival (HR 1.62; P = .003) in patients with KRAS wild-type tumors, but not in those with overall KRAS sequence variation.
Study details: This retrospective study included 1569 patients with CRC with or without KRAS sequence variation who underwent simultaneous (n = 512) or delayed (n = 1057) resection of SLM.
Disclosures: This study was supported by a grant from Shanghai Shenkang Clinical Science and Technology Innovation Project, China. No conflicts of interest were reported.
Source: Wu Y et al. Association of simultaneous vs delayed resection of liver metastasis with complications and survival among adults with colorectal cancer. JAMA Netw Open. 2022;5(9):e2231956 (Sep 19). Doi: 10.1001/jamanetworkopen.2022.31956
Key clinical point: Simultaneous vs delayed resection of synchronous liver metastasis (SLM) was associated with longer survival rates in patients with colorectal cancer (CRC) with KRAS wild-type tumors but not in those with KRAS sequence variation.
Major finding: Perioperative complications within 60 days of surgery were not significantly different in the simultaneous vs delayed resection group (P = .89), but simultaneous vs delayed resection was associated with better 5-year overall survival (hazard ratio [HR] 1.61; P < .001) and cancer-specific survival (HR 1.62; P = .003) in patients with KRAS wild-type tumors, but not in those with overall KRAS sequence variation.
Study details: This retrospective study included 1569 patients with CRC with or without KRAS sequence variation who underwent simultaneous (n = 512) or delayed (n = 1057) resection of SLM.
Disclosures: This study was supported by a grant from Shanghai Shenkang Clinical Science and Technology Innovation Project, China. No conflicts of interest were reported.
Source: Wu Y et al. Association of simultaneous vs delayed resection of liver metastasis with complications and survival among adults with colorectal cancer. JAMA Netw Open. 2022;5(9):e2231956 (Sep 19). Doi: 10.1001/jamanetworkopen.2022.31956
Key clinical point: Simultaneous vs delayed resection of synchronous liver metastasis (SLM) was associated with longer survival rates in patients with colorectal cancer (CRC) with KRAS wild-type tumors but not in those with KRAS sequence variation.
Major finding: Perioperative complications within 60 days of surgery were not significantly different in the simultaneous vs delayed resection group (P = .89), but simultaneous vs delayed resection was associated with better 5-year overall survival (hazard ratio [HR] 1.61; P < .001) and cancer-specific survival (HR 1.62; P = .003) in patients with KRAS wild-type tumors, but not in those with overall KRAS sequence variation.
Study details: This retrospective study included 1569 patients with CRC with or without KRAS sequence variation who underwent simultaneous (n = 512) or delayed (n = 1057) resection of SLM.
Disclosures: This study was supported by a grant from Shanghai Shenkang Clinical Science and Technology Innovation Project, China. No conflicts of interest were reported.
Source: Wu Y et al. Association of simultaneous vs delayed resection of liver metastasis with complications and survival among adults with colorectal cancer. JAMA Netw Open. 2022;5(9):e2231956 (Sep 19). Doi: 10.1001/jamanetworkopen.2022.31956