Article

Key clinical point: Pain alleviation by tofacitinib in patients with psoriatic arthritis (PsA) was mostly due to improvement in itch, enthesitis, and C-reactive protein (CRP) levels.

Major finding: Tofacitinib predominantly reduced pain indirectly (70.5%; P < .0001), as indicated by improvements in the Itch Severity Item score (37.4%; P = .0002), Leeds Enthesitis Index score (17.8%; P = .0157), and CRP levels (15.3%; P = .0107).

Study details: Findings are from a mediation analysis of pooled data from 2 phase 3 studies (OPAL Broaden and OPAL Beyond) including 474 patients with active PsA who received tofacitinib 5 mg twice daily or placebo.

Disclosures: This study was funded by Pfizer Inc. Four authors declared being employees and shareholders of Pfizer, and the other authors reported ties with several sources.

Source: de Vlam K et al. Identifying and quantifying the role of inflammation in pain reduction for patients with psoriatic arthritis treated with tofacitinib: A mediation analysis. Rheumatol Ther. 2022;9(5):1451-1464 (Sep 8). Doi: 10.1007/s40744-022-00482-5.

Key clinical point: Pain alleviation by tofacitinib in patients with psoriatic arthritis (PsA) was mostly due to improvement in itch, enthesitis, and C-reactive protein (CRP) levels.

Major finding: Tofacitinib predominantly reduced pain indirectly (70.5%; P < .0001), as indicated by improvements in the Itch Severity Item score (37.4%; P = .0002), Leeds Enthesitis Index score (17.8%; P = .0157), and CRP levels (15.3%; P = .0107).

Study details: Findings are from a mediation analysis of pooled data from 2 phase 3 studies (OPAL Broaden and OPAL Beyond) including 474 patients with active PsA who received tofacitinib 5 mg twice daily or placebo.

Disclosures: This study was funded by Pfizer Inc. Four authors declared being employees and shareholders of Pfizer, and the other authors reported ties with several sources.

Source: de Vlam K et al. Identifying and quantifying the role of inflammation in pain reduction for patients with psoriatic arthritis treated with tofacitinib: A mediation analysis. Rheumatol Ther. 2022;9(5):1451-1464 (Sep 8). Doi: 10.1007/s40744-022-00482-5.

Key clinical point: Pain alleviation by tofacitinib in patients with psoriatic arthritis (PsA) was mostly due to improvement in itch, enthesitis, and C-reactive protein (CRP) levels.

Major finding: Tofacitinib predominantly reduced pain indirectly (70.5%; P < .0001), as indicated by improvements in the Itch Severity Item score (37.4%; P = .0002), Leeds Enthesitis Index score (17.8%; P = .0157), and CRP levels (15.3%; P = .0107).

Study details: Findings are from a mediation analysis of pooled data from 2 phase 3 studies (OPAL Broaden and OPAL Beyond) including 474 patients with active PsA who received tofacitinib 5 mg twice daily or placebo.

Disclosures: This study was funded by Pfizer Inc. Four authors declared being employees and shareholders of Pfizer, and the other authors reported ties with several sources.

Source: de Vlam K et al. Identifying and quantifying the role of inflammation in pain reduction for patients with psoriatic arthritis treated with tofacitinib: A mediation analysis. Rheumatol Ther. 2022;9(5):1451-1464 (Sep 8). Doi: 10.1007/s40744-022-00482-5.

Key clinical point: Biologics improved disease activity (DA) in a real-world population of patients with psoriatic arthritis (PsA) in Italy.

Major finding: At 6 months, a substantially high proportion of patients receiving biologics achieved the European league against rheumatism (EULAR) DA Score 28 (71.8%; 95% CI, 66.7%-76.8%), with outcomes being similar with secukinumab (73.4%; 95% CI, 65.8%-81.1%) and tumor necrosis factor-inhibitors (71.9%; 95% CI, 64.9%-78.8%). The responder rate was 68.0% at year 1.

Study details: Findings are from a multicenter, noninterventional, cohort study including 399 patients with PsA, of which 308 were evaluable at 6 months and 297 patients were evaluable at 1 year. Most patients received biologics for ≥6 months.

Disclosures: This study was supported by a grant from Novartis Farma S.p.A. Origgio. Three authors declared being part-time/regular employees of Novartis Farma or MediNeos Observational Research, hired by Novartis Farma. The authors declared receiving honoraria, speaker fees, and/or scientific support from other sources.

Source: Colombo D et al. Real-world evidence of biologic treatments in psoriatic arthritis in Italy: Results of the CHRONOS (EffeCtiveness of biologic treatments for psoriatic artHRitis in Italy: An ObservatioNal lOngitudinal Study of real-life clinical practice) observational longitudinal study. BMC Rheumatol. 2022;6(1):57 (Sep 12). Doi: 10.1186/s41927-022-00284-w.

Key clinical point: Biologics improved disease activity (DA) in a real-world population of patients with psoriatic arthritis (PsA) in Italy.

Major finding: At 6 months, a substantially high proportion of patients receiving biologics achieved the European league against rheumatism (EULAR) DA Score 28 (71.8%; 95% CI, 66.7%-76.8%), with outcomes being similar with secukinumab (73.4%; 95% CI, 65.8%-81.1%) and tumor necrosis factor-inhibitors (71.9%; 95% CI, 64.9%-78.8%). The responder rate was 68.0% at year 1.

Study details: Findings are from a multicenter, noninterventional, cohort study including 399 patients with PsA, of which 308 were evaluable at 6 months and 297 patients were evaluable at 1 year. Most patients received biologics for ≥6 months.

Disclosures: This study was supported by a grant from Novartis Farma S.p.A. Origgio. Three authors declared being part-time/regular employees of Novartis Farma or MediNeos Observational Research, hired by Novartis Farma. The authors declared receiving honoraria, speaker fees, and/or scientific support from other sources.

Source: Colombo D et al. Real-world evidence of biologic treatments in psoriatic arthritis in Italy: Results of the CHRONOS (EffeCtiveness of biologic treatments for psoriatic artHRitis in Italy: An ObservatioNal lOngitudinal Study of real-life clinical practice) observational longitudinal study. BMC Rheumatol. 2022;6(1):57 (Sep 12). Doi: 10.1186/s41927-022-00284-w.

Key clinical point: Biologics improved disease activity (DA) in a real-world population of patients with psoriatic arthritis (PsA) in Italy.

Major finding: At 6 months, a substantially high proportion of patients receiving biologics achieved the European league against rheumatism (EULAR) DA Score 28 (71.8%; 95% CI, 66.7%-76.8%), with outcomes being similar with secukinumab (73.4%; 95% CI, 65.8%-81.1%) and tumor necrosis factor-inhibitors (71.9%; 95% CI, 64.9%-78.8%). The responder rate was 68.0% at year 1.

Study details: Findings are from a multicenter, noninterventional, cohort study including 399 patients with PsA, of which 308 were evaluable at 6 months and 297 patients were evaluable at 1 year. Most patients received biologics for ≥6 months.

Disclosures: This study was supported by a grant from Novartis Farma S.p.A. Origgio. Three authors declared being part-time/regular employees of Novartis Farma or MediNeos Observational Research, hired by Novartis Farma. The authors declared receiving honoraria, speaker fees, and/or scientific support from other sources.

Source: Colombo D et al. Real-world evidence of biologic treatments in psoriatic arthritis in Italy: Results of the CHRONOS (EffeCtiveness of biologic treatments for psoriatic artHRitis in Italy: An ObservatioNal lOngitudinal Study of real-life clinical practice) observational longitudinal study. BMC Rheumatol. 2022;6(1):57 (Sep 12). Doi: 10.1186/s41927-022-00284-w.

Key clinical point: Patients with psoriatic arthritis (PsA) who had nail psoriasis were older and had higher disease burden and lower quality of life (QoL) than those without nail psoriasis.

Major finding: Patients with vs. without nail psoriasis had a higher median age (48 vs. 46 years; P = .001), body mass index (29 vs. 28 kg/m²; P = .02), tender (P < .001) and swollen (P = .011) joint counts, and PsAQoL score (6 vs. 4; P = .001).

Study details: Findings are from a cross-sectional, multicenter study including 1,22 patients with PsA, of which 57.5% had nail psoriasis.

Disclosures: This study did not receive any funding. The authors declared no conflicts of interest.

Source: Cengiz G et al. The impact of nail psoriasis on disease activity, quality of life, and clinical variables in patients with psoriatic arthritis: A cross-sectional multicenter study. Int J Rheum Dis. 2022 (Sep 27). Doi:10.1111/1756-185X.14442

Key clinical point: Patients with psoriatic arthritis (PsA) who had nail psoriasis were older and had higher disease burden and lower quality of life (QoL) than those without nail psoriasis.

Major finding: Patients with vs. without nail psoriasis had a higher median age (48 vs. 46 years; P = .001), body mass index (29 vs. 28 kg/m²; P = .02), tender (P < .001) and swollen (P = .011) joint counts, and PsAQoL score (6 vs. 4; P = .001).

Study details: Findings are from a cross-sectional, multicenter study including 1,22 patients with PsA, of which 57.5% had nail psoriasis.

Disclosures: This study did not receive any funding. The authors declared no conflicts of interest.

Source: Cengiz G et al. The impact of nail psoriasis on disease activity, quality of life, and clinical variables in patients with psoriatic arthritis: A cross-sectional multicenter study. Int J Rheum Dis. 2022 (Sep 27). Doi:10.1111/1756-185X.14442

Key clinical point: Patients with psoriatic arthritis (PsA) who had nail psoriasis were older and had higher disease burden and lower quality of life (QoL) than those without nail psoriasis.

Major finding: Patients with vs. without nail psoriasis had a higher median age (48 vs. 46 years; P = .001), body mass index (29 vs. 28 kg/m²; P = .02), tender (P < .001) and swollen (P = .011) joint counts, and PsAQoL score (6 vs. 4; P = .001).

Study details: Findings are from a cross-sectional, multicenter study including 1,22 patients with PsA, of which 57.5% had nail psoriasis.

Disclosures: This study did not receive any funding. The authors declared no conflicts of interest.

Source: Cengiz G et al. The impact of nail psoriasis on disease activity, quality of life, and clinical variables in patients with psoriatic arthritis: A cross-sectional multicenter study. Int J Rheum Dis. 2022 (Sep 27). Doi:10.1111/1756-185X.14442

Key clinical point: Patients with psoriatic arthritis (PsA) and obesity had ~50% lower likelihood of achieving minimal disease activity (MDA) or remission within a year of initiating treatment with biologic or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARD).

Major finding: Odds of achieving MDA (adjusted odds ratio [aOR] 0.45; 95% CI 0.24-0.82) and DAPSA-remission (aOR 0.42; 95% CI 0.21-0.85) were lower in the obese vs normal weight group within the first year; similarly, the overweight group had reduced odds of achieving DAPSA-remission (aOR 0.44; 95% CI 0.24-0.79).

Study details: Findings are from an observational cohort study including 774 adult patients with PsA who started their first b/tsDMARD.

Disclosures: This study did not report any source of funding. The authors declared no conflicts of interest.

Source: Vallejo-Yague E et al. Minimal disease activity and remission in patients with psoriatic arthritis with elevated body mass index: An observational cohort study in the Swiss Clinical Quality Management cohort. BMJ Open. 2022;12(9):e061474 (Sep 17). Doi: 10.1136/bmjopen-2022-061474

Key clinical point: Patients with psoriatic arthritis (PsA) and obesity had ~50% lower likelihood of achieving minimal disease activity (MDA) or remission within a year of initiating treatment with biologic or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARD).

Major finding: Odds of achieving MDA (adjusted odds ratio [aOR] 0.45; 95% CI 0.24-0.82) and DAPSA-remission (aOR 0.42; 95% CI 0.21-0.85) were lower in the obese vs normal weight group within the first year; similarly, the overweight group had reduced odds of achieving DAPSA-remission (aOR 0.44; 95% CI 0.24-0.79).

Study details: Findings are from an observational cohort study including 774 adult patients with PsA who started their first b/tsDMARD.

Disclosures: This study did not report any source of funding. The authors declared no conflicts of interest.

Source: Vallejo-Yague E et al. Minimal disease activity and remission in patients with psoriatic arthritis with elevated body mass index: An observational cohort study in the Swiss Clinical Quality Management cohort. BMJ Open. 2022;12(9):e061474 (Sep 17). Doi: 10.1136/bmjopen-2022-061474

Key clinical point: Patients with psoriatic arthritis (PsA) and obesity had ~50% lower likelihood of achieving minimal disease activity (MDA) or remission within a year of initiating treatment with biologic or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARD).

Major finding: Odds of achieving MDA (adjusted odds ratio [aOR] 0.45; 95% CI 0.24-0.82) and DAPSA-remission (aOR 0.42; 95% CI 0.21-0.85) were lower in the obese vs normal weight group within the first year; similarly, the overweight group had reduced odds of achieving DAPSA-remission (aOR 0.44; 95% CI 0.24-0.79).

Study details: Findings are from an observational cohort study including 774 adult patients with PsA who started their first b/tsDMARD.

Disclosures: This study did not report any source of funding. The authors declared no conflicts of interest.

Source: Vallejo-Yague E et al. Minimal disease activity and remission in patients with psoriatic arthritis with elevated body mass index: An observational cohort study in the Swiss Clinical Quality Management cohort. BMJ Open. 2022;12(9):e061474 (Sep 17). Doi: 10.1136/bmjopen-2022-061474

Key clinical point: Preliminary results from this real-world study demonstrated efficacy of interleukin (IL)-23 inhibitors in patients with psoriatic arthritis (PsA).

Major finding: A substantial proportion of patients with PsA receiving either of the IL-23 inhibitors achieved complete (40.9%) or partial (36.4%) remission compared with only 18.2% of patients who demonstrated no improvement. A higher proportion of patients receiving guselkumab achieved remission or partial remission (38.5% and 46.1%, respectively) than treatment failure (15.4%), with similar outcomes being observed with risankizumab.

Study details: Findings are from a retrospective, observational study including 80 patients with psoriasis who received guselkumab, tildrakizumab, or risankizumab, of which 27.5% of patients had PsA.

Disclosures: This study did not receive any funding. The authors declared serving as consultants, paid speakers, and/or advisors and/or receiving speaking fees or grants from several sources.

Source: Elgaard CDB et al. Guselkumab, tildrakizumab and risankizumab in real-world setting: Drug survival and effectiveness in the treatment of psoriasis and psoriatic arthritis. J Dermatolog Treat. 2022;1-24 (Oct 6). Doi: 10.1080/09546634.2022.2133531.

Key clinical point: Preliminary results from this real-world study demonstrated efficacy of interleukin (IL)-23 inhibitors in patients with psoriatic arthritis (PsA).

Major finding: A substantial proportion of patients with PsA receiving either of the IL-23 inhibitors achieved complete (40.9%) or partial (36.4%) remission compared with only 18.2% of patients who demonstrated no improvement. A higher proportion of patients receiving guselkumab achieved remission or partial remission (38.5% and 46.1%, respectively) than treatment failure (15.4%), with similar outcomes being observed with risankizumab.

Study details: Findings are from a retrospective, observational study including 80 patients with psoriasis who received guselkumab, tildrakizumab, or risankizumab, of which 27.5% of patients had PsA.

Disclosures: This study did not receive any funding. The authors declared serving as consultants, paid speakers, and/or advisors and/or receiving speaking fees or grants from several sources.

Source: Elgaard CDB et al. Guselkumab, tildrakizumab and risankizumab in real-world setting: Drug survival and effectiveness in the treatment of psoriasis and psoriatic arthritis. J Dermatolog Treat. 2022;1-24 (Oct 6). Doi: 10.1080/09546634.2022.2133531.

Key clinical point: Preliminary results from this real-world study demonstrated efficacy of interleukin (IL)-23 inhibitors in patients with psoriatic arthritis (PsA).

Major finding: A substantial proportion of patients with PsA receiving either of the IL-23 inhibitors achieved complete (40.9%) or partial (36.4%) remission compared with only 18.2% of patients who demonstrated no improvement. A higher proportion of patients receiving guselkumab achieved remission or partial remission (38.5% and 46.1%, respectively) than treatment failure (15.4%), with similar outcomes being observed with risankizumab.

Study details: Findings are from a retrospective, observational study including 80 patients with psoriasis who received guselkumab, tildrakizumab, or risankizumab, of which 27.5% of patients had PsA.

Disclosures: This study did not receive any funding. The authors declared serving as consultants, paid speakers, and/or advisors and/or receiving speaking fees or grants from several sources.

Source: Elgaard CDB et al. Guselkumab, tildrakizumab and risankizumab in real-world setting: Drug survival and effectiveness in the treatment of psoriasis and psoriatic arthritis. J Dermatolog Treat. 2022;1-24 (Oct 6). Doi: 10.1080/09546634.2022.2133531.

Key clinical point: Guselkumab demonstrated promising efficacy and was well tolerated in a real-world population of patients with psoriatic arthritis (PsA) and psoriasis.

Major finding: Before starting guselkumab, 48% of patients had moderate/high disease activity in PsA (DAPSA). In this subgroup, the mean DAPSA score reduced from 29 to 20, 16, and 14 at weeks 12, 24, and 52, respectively (P < .0001). Only 2.2% of patients reported mild adverse events.

Study details: Findings are from a multicenter, retrospective, observational study including 90 patients with PsA and concomitant psoriasis who started treatment with guselkumab.

Disclosures: This study did not receive any funding. The authors declared no conflicts of interest.

Source: Rocamora V et al. Guselkumab effectiveness and survival in patients with psoriasis and psoriatic arthritis: Multicenter analysis in daily clinical practice by the Spanish Psoriasis Group. Dermatol Ther. 2022 (Sep 29). Doi: 10.1111/dth.15865

Key clinical point: Guselkumab demonstrated promising efficacy and was well tolerated in a real-world population of patients with psoriatic arthritis (PsA) and psoriasis.

Major finding: Before starting guselkumab, 48% of patients had moderate/high disease activity in PsA (DAPSA). In this subgroup, the mean DAPSA score reduced from 29 to 20, 16, and 14 at weeks 12, 24, and 52, respectively (P < .0001). Only 2.2% of patients reported mild adverse events.

Study details: Findings are from a multicenter, retrospective, observational study including 90 patients with PsA and concomitant psoriasis who started treatment with guselkumab.

Disclosures: This study did not receive any funding. The authors declared no conflicts of interest.

Source: Rocamora V et al. Guselkumab effectiveness and survival in patients with psoriasis and psoriatic arthritis: Multicenter analysis in daily clinical practice by the Spanish Psoriasis Group. Dermatol Ther. 2022 (Sep 29). Doi: 10.1111/dth.15865

Key clinical point: Guselkumab demonstrated promising efficacy and was well tolerated in a real-world population of patients with psoriatic arthritis (PsA) and psoriasis.

Major finding: Before starting guselkumab, 48% of patients had moderate/high disease activity in PsA (DAPSA). In this subgroup, the mean DAPSA score reduced from 29 to 20, 16, and 14 at weeks 12, 24, and 52, respectively (P < .0001). Only 2.2% of patients reported mild adverse events.

Study details: Findings are from a multicenter, retrospective, observational study including 90 patients with PsA and concomitant psoriasis who started treatment with guselkumab.

Disclosures: This study did not receive any funding. The authors declared no conflicts of interest.

Source: Rocamora V et al. Guselkumab effectiveness and survival in patients with psoriasis and psoriatic arthritis: Multicenter analysis in daily clinical practice by the Spanish Psoriasis Group. Dermatol Ther. 2022 (Sep 29). Doi: 10.1111/dth.15865

Key clinical point: Inflammatory bowel disease (IBD), particularly Crohn's disease, is a causal risk factor for psoriatic arthritis (PsA).

Major finding: Genetically predicted IBD was associated with a higher risk for PsA (pooled odds ratio [OR] 1.11; P = .003) with the risk being majorly mediated by Crohn’s disease (OR 1.12; P = .002) and not ulcerative colitis (P = .70).

Study details: Findings are from a bidirectional 2-sample mendelian randomization study including 12,882 patients with IBD and 21,770 matched-controls and 5621 patients with psoriasis and 2063 patients with PsA who were compared with 252,323 controls.

Disclosures: This study did not report any source of funding. The authors declared no conflicts of interest.

Source: Freuer D et al. Association between inflammatory bowel disease and both psoriasis and psoriatic arthritis: A bidirectional 2-sample mendelian randomization study. JAMA Dermatol. 2022 (Sep 14). Doi: 10.1001/jamadermatol.2022.3682

Key clinical point: Inflammatory bowel disease (IBD), particularly Crohn's disease, is a causal risk factor for psoriatic arthritis (PsA).

Major finding: Genetically predicted IBD was associated with a higher risk for PsA (pooled odds ratio [OR] 1.11; P = .003) with the risk being majorly mediated by Crohn’s disease (OR 1.12; P = .002) and not ulcerative colitis (P = .70).

Study details: Findings are from a bidirectional 2-sample mendelian randomization study including 12,882 patients with IBD and 21,770 matched-controls and 5621 patients with psoriasis and 2063 patients with PsA who were compared with 252,323 controls.

Disclosures: This study did not report any source of funding. The authors declared no conflicts of interest.

Source: Freuer D et al. Association between inflammatory bowel disease and both psoriasis and psoriatic arthritis: A bidirectional 2-sample mendelian randomization study. JAMA Dermatol. 2022 (Sep 14). Doi: 10.1001/jamadermatol.2022.3682

Key clinical point: Inflammatory bowel disease (IBD), particularly Crohn's disease, is a causal risk factor for psoriatic arthritis (PsA).

Major finding: Genetically predicted IBD was associated with a higher risk for PsA (pooled odds ratio [OR] 1.11; P = .003) with the risk being majorly mediated by Crohn’s disease (OR 1.12; P = .002) and not ulcerative colitis (P = .70).

Study details: Findings are from a bidirectional 2-sample mendelian randomization study including 12,882 patients with IBD and 21,770 matched-controls and 5621 patients with psoriasis and 2063 patients with PsA who were compared with 252,323 controls.

Disclosures: This study did not report any source of funding. The authors declared no conflicts of interest.

Source: Freuer D et al. Association between inflammatory bowel disease and both psoriasis and psoriatic arthritis: A bidirectional 2-sample mendelian randomization study. JAMA Dermatol. 2022 (Sep 14). Doi: 10.1001/jamadermatol.2022.3682

Key clinical point: Higher rehabilitation dose (>8 physical/occupational therapy visits) improved physical function in adults with rheumatoid arthritis (RA) who reported new rehabilitation visits after at least 1 year without rehabilitation visits.

Major finding: Worse physical function at baseline was associated with a higher rehabilitation dose (adjusted odds ratio [aOR] 1.29; 95% CI 1.04-1.60). Higher vs. lower rehabilitation dose was also associated with clinically favorable changes in physical function (aOR 1.41; 95% CI 1.03-1.92).

Study details: This prospective cohort analysis evaluated the data of 1,381 adults with RA from the FORWARD registry who reported new rehabilitation visits of low/medium/high dose over 6 months after no rehabilitation visits for past ≥1 year.

Disclosures: This study did not receive any specific funding. LM Thoma and E Wellsandt reported receiving support from the Rheumatology Research Foundation and/or National Institutes of Health.

Source: Thoma LM et al. Examining rehabilitation dose in adults with rheumatoid arthritis: Association with baseline factors and change in clinical outcomes. Arthritis Care Res (Hoboken). 2022 (Sep 12). Doi: 10.1002/acr.25019

Key clinical point: Higher rehabilitation dose (>8 physical/occupational therapy visits) improved physical function in adults with rheumatoid arthritis (RA) who reported new rehabilitation visits after at least 1 year without rehabilitation visits.

Major finding: Worse physical function at baseline was associated with a higher rehabilitation dose (adjusted odds ratio [aOR] 1.29; 95% CI 1.04-1.60). Higher vs. lower rehabilitation dose was also associated with clinically favorable changes in physical function (aOR 1.41; 95% CI 1.03-1.92).

Study details: This prospective cohort analysis evaluated the data of 1,381 adults with RA from the FORWARD registry who reported new rehabilitation visits of low/medium/high dose over 6 months after no rehabilitation visits for past ≥1 year.

Disclosures: This study did not receive any specific funding. LM Thoma and E Wellsandt reported receiving support from the Rheumatology Research Foundation and/or National Institutes of Health.

Source: Thoma LM et al. Examining rehabilitation dose in adults with rheumatoid arthritis: Association with baseline factors and change in clinical outcomes. Arthritis Care Res (Hoboken). 2022 (Sep 12). Doi: 10.1002/acr.25019

Key clinical point: Higher rehabilitation dose (>8 physical/occupational therapy visits) improved physical function in adults with rheumatoid arthritis (RA) who reported new rehabilitation visits after at least 1 year without rehabilitation visits.

Major finding: Worse physical function at baseline was associated with a higher rehabilitation dose (adjusted odds ratio [aOR] 1.29; 95% CI 1.04-1.60). Higher vs. lower rehabilitation dose was also associated with clinically favorable changes in physical function (aOR 1.41; 95% CI 1.03-1.92).

Study details: This prospective cohort analysis evaluated the data of 1,381 adults with RA from the FORWARD registry who reported new rehabilitation visits of low/medium/high dose over 6 months after no rehabilitation visits for past ≥1 year.

Disclosures: This study did not receive any specific funding. LM Thoma and E Wellsandt reported receiving support from the Rheumatology Research Foundation and/or National Institutes of Health.

Source: Thoma LM et al. Examining rehabilitation dose in adults with rheumatoid arthritis: Association with baseline factors and change in clinical outcomes. Arthritis Care Res (Hoboken). 2022 (Sep 12). Doi: 10.1002/acr.25019

Key clinical point: The prevalence for osteoporosis continues to remain high in patients with rheumatoid arthritis (RA) despite significant advances in diagnostic methods, prevention, and treatment.

Major finding: Overall, osteoporosis was highly prevalent in patients with RA (prevalence, 27.6%; 95% CI, 23.9%-31.3%), with the prevalence being the highest in studies during 2011-2015 (36.2%; 95% CI, 24.5%-47.8%), followed by 2016-2021 (27.1%; 95% CI, 20.7%-33.4%), and before 2010 (21.6%; 95% CI, 15.8%-27.4%).

Study details: Findings are from a systematic review and meta-analysis of 57 studies including 227,812 patients with RA, of which 64,290 reported osteoporosis.

Disclosures: This study was funded by Arak University of Medical Sciences. The authors declared no conflicts of interest.

Source: Moshayedi S et al. The prevalence of osteoporosis in rheumatoid arthritis patient: A systematic review and meta-analysis. Sci Rep. 2022;12(1):15844 (Sep 23). Doi: 10.1038/s41598-022-20016-x.

Key clinical point: The prevalence for osteoporosis continues to remain high in patients with rheumatoid arthritis (RA) despite significant advances in diagnostic methods, prevention, and treatment.

Major finding: Overall, osteoporosis was highly prevalent in patients with RA (prevalence, 27.6%; 95% CI, 23.9%-31.3%), with the prevalence being the highest in studies during 2011-2015 (36.2%; 95% CI, 24.5%-47.8%), followed by 2016-2021 (27.1%; 95% CI, 20.7%-33.4%), and before 2010 (21.6%; 95% CI, 15.8%-27.4%).

Study details: Findings are from a systematic review and meta-analysis of 57 studies including 227,812 patients with RA, of which 64,290 reported osteoporosis.

Disclosures: This study was funded by Arak University of Medical Sciences. The authors declared no conflicts of interest.

Source: Moshayedi S et al. The prevalence of osteoporosis in rheumatoid arthritis patient: A systematic review and meta-analysis. Sci Rep. 2022;12(1):15844 (Sep 23). Doi: 10.1038/s41598-022-20016-x.

Key clinical point: The prevalence for osteoporosis continues to remain high in patients with rheumatoid arthritis (RA) despite significant advances in diagnostic methods, prevention, and treatment.

Major finding: Overall, osteoporosis was highly prevalent in patients with RA (prevalence, 27.6%; 95% CI, 23.9%-31.3%), with the prevalence being the highest in studies during 2011-2015 (36.2%; 95% CI, 24.5%-47.8%), followed by 2016-2021 (27.1%; 95% CI, 20.7%-33.4%), and before 2010 (21.6%; 95% CI, 15.8%-27.4%).

Study details: Findings are from a systematic review and meta-analysis of 57 studies including 227,812 patients with RA, of which 64,290 reported osteoporosis.

Disclosures: This study was funded by Arak University of Medical Sciences. The authors declared no conflicts of interest.

Source: Moshayedi S et al. The prevalence of osteoporosis in rheumatoid arthritis patient: A systematic review and meta-analysis. Sci Rep. 2022;12(1):15844 (Sep 23). Doi: 10.1038/s41598-022-20016-x.

Key clinical point: Serum levels of interferon beta (IFNβ) may distinguish early from late relapse after biologic disease-modifying antirheumatic drug (bDMARD) withdrawal in patients with rheumatoid arthritis (RA).

Major finding: Patients with serum IFNβ levels of 3.38 vs. <3.38 in log₂ had a significantly lower probability of sustained remission during the first 6 months of bDMARD withdrawal (log-rank test, P = .0177). Serum IFNβ levels of 3.38 in log₂ at the time of bDMARD withdrawal predicted early vs. late relapse in patients with highly probable relapses (area under the curve, 0.833) and patients with lower IFNβ levels (<3.38 in log₂) were able to safely discontinue bDMARD.

Study details: This prospective study included 40 patients with RA who maintained clinical remission with bDMARDs for >12 months, of which 26 relapsed at some point after bDMARD withdrawal.

Disclosures: This study was partially supported by unlimited research fund from Chugai Pharm, Eisai, and Mitsubishi-Tanabe provided to S Minota. The authors declared no conflicts of interest.

Source: Sakashita E et al. Serum level of IFNβ distinguishes early from late relapses after biologics withdrawal in rheumatoid arthritis. Sci Rep. 2022;12(1):16547 (Oct 3). Doi: 10.1038/s41598-022-21160-0.

Key clinical point: Serum levels of interferon beta (IFNβ) may distinguish early from late relapse after biologic disease-modifying antirheumatic drug (bDMARD) withdrawal in patients with rheumatoid arthritis (RA).

Major finding: Patients with serum IFNβ levels of 3.38 vs. <3.38 in log₂ had a significantly lower probability of sustained remission during the first 6 months of bDMARD withdrawal (log-rank test, P = .0177). Serum IFNβ levels of 3.38 in log₂ at the time of bDMARD withdrawal predicted early vs. late relapse in patients with highly probable relapses (area under the curve, 0.833) and patients with lower IFNβ levels (<3.38 in log₂) were able to safely discontinue bDMARD.

Study details: This prospective study included 40 patients with RA who maintained clinical remission with bDMARDs for >12 months, of which 26 relapsed at some point after bDMARD withdrawal.

Disclosures: This study was partially supported by unlimited research fund from Chugai Pharm, Eisai, and Mitsubishi-Tanabe provided to S Minota. The authors declared no conflicts of interest.

Source: Sakashita E et al. Serum level of IFNβ distinguishes early from late relapses after biologics withdrawal in rheumatoid arthritis. Sci Rep. 2022;12(1):16547 (Oct 3). Doi: 10.1038/s41598-022-21160-0.

Key clinical point: Serum levels of interferon beta (IFNβ) may distinguish early from late relapse after biologic disease-modifying antirheumatic drug (bDMARD) withdrawal in patients with rheumatoid arthritis (RA).

Major finding: Patients with serum IFNβ levels of 3.38 vs. <3.38 in log₂ had a significantly lower probability of sustained remission during the first 6 months of bDMARD withdrawal (log-rank test, P = .0177). Serum IFNβ levels of 3.38 in log₂ at the time of bDMARD withdrawal predicted early vs. late relapse in patients with highly probable relapses (area under the curve, 0.833) and patients with lower IFNβ levels (<3.38 in log₂) were able to safely discontinue bDMARD.

Study details: This prospective study included 40 patients with RA who maintained clinical remission with bDMARDs for >12 months, of which 26 relapsed at some point after bDMARD withdrawal.

Disclosures: This study was partially supported by unlimited research fund from Chugai Pharm, Eisai, and Mitsubishi-Tanabe provided to S Minota. The authors declared no conflicts of interest.

Source: Sakashita E et al. Serum level of IFNβ distinguishes early from late relapses after biologics withdrawal in rheumatoid arthritis. Sci Rep. 2022;12(1):16547 (Oct 3). Doi: 10.1038/s41598-022-21160-0.