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Mechanical Ventilation and Airways Section

Noninvasive ventilation

Noninvasive ventilation (NIV) is a ventilation modality that supports breathing by using mechanically assisted breaths without the need for intubation or a surgical airway. NIV is divided into two main types, negative-pressure ventilation (NPV) and noninvasive positive-pressure ventilation (NIPPV).

NPV

NPV periodically generates a negative (subatmospheric) pressure on the thorax wall, reflecting the natural breathing mechanism. As this negative pressure is transmitted into the thorax, normal atmospheric pressure air outside the thorax is pulled in for inhalation. Initiated by the negative pressure generator switching off, exhalation is passive due to elastic recoil of the lung and chest wall. The iron lung was a neck-to-toe horizontal cylinder used for NPV during the polio epidemic. New NPV devices are designed to fit the thorax only, using a cuirass (a torso-covering body armor molded shell).

For years, NPV use declined as NIPPV use increased. However, during the shortage of NIPPV devices during COVID and a recent recall of certain CPAP devices, NPV use has increased. NPV is an excellent alternative for those who cannot tolerate a facial mask due to facial deformity, claustrophobia, or excessive airway secretion (Corrado A et al. European Resp J. 2002;20[1]:187).
 

NIPPV

NIPPV is divided into several subtypes, including continuous positive airway pressure (CPAP), bilevel positive airway pressure (BPAP or BiPAP), and average volume-assured pressure support (AVAPS or VAPS). CPAP is defined as a single pressure delivered in inhalation (Pi) and exhalation (Pe). The increased mean airway pressure provides improved oxygenation (O₂) but not ventilation (CO₂). BPAP uses dual pressures with Pi higher than Pe. The increased mean airway pressure provides improved O₂ while the difference between Pi minus Pe increases ventilation and decreases CO₂.

AVAPS is a form of BPAP where Pi varies in an automated range to achieve the ordered tidal volume. In AVAPS, the generator adjusts Pi based on the average delivered tidal volume. If the average delivered tidal volume is less than the set tidal volume, Pi gradually increases while not exceeding Pi Max. Patients notice improved comfort of AVAPS with a variable Pi vs. BPAP with a fixed Pi (Frank A et al. Chest. 2018;154[4]:1060A).

Samantha Tauscher, DO, Resident-in-Training

Herbert Patrick, MD, MSEE, FCCP , Member-at-Large

Mechanical Ventilation and Airways Section

Noninvasive ventilation

Noninvasive ventilation (NIV) is a ventilation modality that supports breathing by using mechanically assisted breaths without the need for intubation or a surgical airway. NIV is divided into two main types, negative-pressure ventilation (NPV) and noninvasive positive-pressure ventilation (NIPPV).

NPV

NPV periodically generates a negative (subatmospheric) pressure on the thorax wall, reflecting the natural breathing mechanism. As this negative pressure is transmitted into the thorax, normal atmospheric pressure air outside the thorax is pulled in for inhalation. Initiated by the negative pressure generator switching off, exhalation is passive due to elastic recoil of the lung and chest wall. The iron lung was a neck-to-toe horizontal cylinder used for NPV during the polio epidemic. New NPV devices are designed to fit the thorax only, using a cuirass (a torso-covering body armor molded shell).

For years, NPV use declined as NIPPV use increased. However, during the shortage of NIPPV devices during COVID and a recent recall of certain CPAP devices, NPV use has increased. NPV is an excellent alternative for those who cannot tolerate a facial mask due to facial deformity, claustrophobia, or excessive airway secretion (Corrado A et al. European Resp J. 2002;20[1]:187).
 

NIPPV

NIPPV is divided into several subtypes, including continuous positive airway pressure (CPAP), bilevel positive airway pressure (BPAP or BiPAP), and average volume-assured pressure support (AVAPS or VAPS). CPAP is defined as a single pressure delivered in inhalation (Pi) and exhalation (Pe). The increased mean airway pressure provides improved oxygenation (O₂) but not ventilation (CO₂). BPAP uses dual pressures with Pi higher than Pe. The increased mean airway pressure provides improved O₂ while the difference between Pi minus Pe increases ventilation and decreases CO₂.

AVAPS is a form of BPAP where Pi varies in an automated range to achieve the ordered tidal volume. In AVAPS, the generator adjusts Pi based on the average delivered tidal volume. If the average delivered tidal volume is less than the set tidal volume, Pi gradually increases while not exceeding Pi Max. Patients notice improved comfort of AVAPS with a variable Pi vs. BPAP with a fixed Pi (Frank A et al. Chest. 2018;154[4]:1060A).

Samantha Tauscher, DO, Resident-in-Training

Herbert Patrick, MD, MSEE, FCCP , Member-at-Large

Mechanical Ventilation and Airways Section

Noninvasive ventilation

Noninvasive ventilation (NIV) is a ventilation modality that supports breathing by using mechanically assisted breaths without the need for intubation or a surgical airway. NIV is divided into two main types, negative-pressure ventilation (NPV) and noninvasive positive-pressure ventilation (NIPPV).

NPV

NPV periodically generates a negative (subatmospheric) pressure on the thorax wall, reflecting the natural breathing mechanism. As this negative pressure is transmitted into the thorax, normal atmospheric pressure air outside the thorax is pulled in for inhalation. Initiated by the negative pressure generator switching off, exhalation is passive due to elastic recoil of the lung and chest wall. The iron lung was a neck-to-toe horizontal cylinder used for NPV during the polio epidemic. New NPV devices are designed to fit the thorax only, using a cuirass (a torso-covering body armor molded shell).

For years, NPV use declined as NIPPV use increased. However, during the shortage of NIPPV devices during COVID and a recent recall of certain CPAP devices, NPV use has increased. NPV is an excellent alternative for those who cannot tolerate a facial mask due to facial deformity, claustrophobia, or excessive airway secretion (Corrado A et al. European Resp J. 2002;20[1]:187).
 

NIPPV

NIPPV is divided into several subtypes, including continuous positive airway pressure (CPAP), bilevel positive airway pressure (BPAP or BiPAP), and average volume-assured pressure support (AVAPS or VAPS). CPAP is defined as a single pressure delivered in inhalation (Pi) and exhalation (Pe). The increased mean airway pressure provides improved oxygenation (O₂) but not ventilation (CO₂). BPAP uses dual pressures with Pi higher than Pe. The increased mean airway pressure provides improved O₂ while the difference between Pi minus Pe increases ventilation and decreases CO₂.

AVAPS is a form of BPAP where Pi varies in an automated range to achieve the ordered tidal volume. In AVAPS, the generator adjusts Pi based on the average delivered tidal volume. If the average delivered tidal volume is less than the set tidal volume, Pi gradually increases while not exceeding Pi Max. Patients notice improved comfort of AVAPS with a variable Pi vs. BPAP with a fixed Pi (Frank A et al. Chest. 2018;154[4]:1060A).

Samantha Tauscher, DO, Resident-in-Training

Herbert Patrick, MD, MSEE, FCCP , Member-at-Large

The SARS-CoV-2 pandemic changed the way intensivists approach extracorporeal membrane oxygenation (ECMO). Patients with COVID-19 acute respiratory distress syndrome (ARDS) placed on ECMO have a high prevalence of right ventricular (RV) failure, which is associated with reduced survival (Maharaj V et al. ASAIO Journal. 2022;68[6]:772). In 2021, our institution supported 51 patients with COVID-19 ARDS with ECMO: 51% developed RV failure, defined as a clinical syndrome (reduced cardiac output) in the presence of RV dysfunction on transthoracic echocardiogram (TTE) (Marra A et al. Chest. 2022;161[2]:535). Total numbers for RV dysfunction and RV dilation on TTE were 78% and 91% respectively, so many of those with RV changes on TTE did not progress to clinical failure. In essence then, TTE signs of RV dysfunction are sensitive but not specific for clinical RV failure.

Rates for survival to decannulation were far lower when RV failure was present (27%) vs. absent (84%). Given these numbers, we felt a reduction in RV failure would be an important target for improving outcomes for patients with COVID-19 ARDS receiving ECMO. Existing studies on RV failure in patients with ARDS receiving ECMO are plagued by scant data, small sample sizes, differences in diagnostic criteria, and heterogenous treatment approaches. Despite these limitations, we felt the need to make changes in our approach to RV management.

Because outcomes once clinical RV-failure occurs are so poor, we focused on prevention. While we’re short on data and evidence-based medicine (EBM) here, we know a lot about the physiology of COVID19, the pulmonary vasculature, and the right side of the heart. There are multiple physiologic and disease-related pathways that converge to produce RV-failure in patients with COVID-19 ARDS on ECMO (Sato R et al. Crit Care. 2021;25:172). Ongoing relative hypoxemia, hypercapnia, acidemia, and microvascular thromboses/immunothromboses can all lead to increased pulmonary vascular resistance (PVR) and an increased workload for the RV (Zochios V et al. ASAIO Journal. 2022; 68[4]:456). ARDS management typically involves high positive end-expiratory pressure (PEEP), which can produce RV-PA uncoupling (Wanner P et al. J Clin Med. 2020;9:432).

We do know that ECMO relieves the stress on the right side of the heart by improving hypoxemia, hypercapnia, and acidemia while allowing for reduction in PEEP (Zochios V et al. ASAIO Journal. 2022; 68[4]:456). In addition to ECMO, proning and pulmonary vasodilators offload RV by further reducing pulmonary pressures (Sato R et al. Crit Care. 2021;25:172). Lastly, a right ventricular assist device (RVAD) can dissipate the work required by the RV and prevent decompensation. Collectively, these therapies can be considered preventive.

Knowing the RV parameters on RV are sensitive but not specific for outcomes though, when should some of these treatments be instituted? It’s clear that once RV failure has developed it’s probably too late, but it’s hard to find data to guide us on when to act. One institution used right ventricular assist devices (RVADs) at the time of ECMO initiation with protocolized care and achieved a survival to discharge rate of 73% (Mustafa AK et al. JAMA Surgery. 2020;155[10]:990). The publication generated enthusiasm for RVAD support with ECMO, but it’s possible the protocolized care drove the high survival rate, at least in part.

At our institution, we developed our own protocol for evaluation of the RV with proactive treatment based on specific targets. We performed daily, bedside TTE and assessed the RV fractional area of change (FAC) and outflow tract velocity time integral (VTI). These parameters provide a quantitative assessment of global RV function, and FAC is directly related to ability to wean from ECMO support (Maharaj V et al. ASAIO Journal. 2022;68[6]:772). We avoided using the tricuspid annular plain systolic excursion (TAPSE) due to its poor sensitivity (Marra AM et al. Chest. 2022;161[2]:535). Patients receiving ECMO with subjective, global mild to moderate RV dysfunction on TTE with worsening clinical data, an FAC of 20%-35%, and a VTI of 10-14 cm were treated with aggressive diuresis, pulmonary vasodilators, and inotropy for 48 hours. If there was no improvement or deterioration, an RVAD was placed. For patients with signs of severe RV dysfunction (FAC < 20% or VTI < 10 cm), we proceeded directly to RVAD. We’re currently collecting data and tracking outcomes.

While data exist on various interventions in RV failure due to COVID-19 ARDS with ECMO, our understanding of this disease is still in its infancy. The optimal timing of interventions to manage and prevent RV failure is not known. We would argue that those who wait for RV failure to occur before instituting protective or supportive therapies are missing the opportunity to impact outcomes. We currently do not have the evidence to support the specific protocol we’ve outlined here and instituted at our hospital. However, we do believe there’s enough literature and experience to support the concept that close monitoring of RV function is critical for patients with COVID19 ARDS receiving ECMO. Failure to anticipate worsening function on the way to failure means reacting to it rather than staving it off. By then, it’s too late.
 

Dr. Thomas is Maj, USAF, assistant professor, pulmonary/critical care; Dr. O’Neil is Maj, USAF, pediatric and ECMO intensivist, PICU medical director; and Dr. Villalobos is Capt, USAF, assistant professor, pulmonary/critical care, medical ICU director, Brooke Army Medical Center, San Antonio, Tex. The view(s) expressed herein are those of the author(s) and do not reflect the official policy or position of Brooke Army Medical Center, the U.S. Army Medical Department, the U.S. Army Office of the Surgeon General, the Department of the Army, the Department of the Air Force, or the Department of Defense or the U.S. government.

The SARS-CoV-2 pandemic changed the way intensivists approach extracorporeal membrane oxygenation (ECMO). Patients with COVID-19 acute respiratory distress syndrome (ARDS) placed on ECMO have a high prevalence of right ventricular (RV) failure, which is associated with reduced survival (Maharaj V et al. ASAIO Journal. 2022;68[6]:772). In 2021, our institution supported 51 patients with COVID-19 ARDS with ECMO: 51% developed RV failure, defined as a clinical syndrome (reduced cardiac output) in the presence of RV dysfunction on transthoracic echocardiogram (TTE) (Marra A et al. Chest. 2022;161[2]:535). Total numbers for RV dysfunction and RV dilation on TTE were 78% and 91% respectively, so many of those with RV changes on TTE did not progress to clinical failure. In essence then, TTE signs of RV dysfunction are sensitive but not specific for clinical RV failure.

Rates for survival to decannulation were far lower when RV failure was present (27%) vs. absent (84%). Given these numbers, we felt a reduction in RV failure would be an important target for improving outcomes for patients with COVID-19 ARDS receiving ECMO. Existing studies on RV failure in patients with ARDS receiving ECMO are plagued by scant data, small sample sizes, differences in diagnostic criteria, and heterogenous treatment approaches. Despite these limitations, we felt the need to make changes in our approach to RV management.

Because outcomes once clinical RV-failure occurs are so poor, we focused on prevention. While we’re short on data and evidence-based medicine (EBM) here, we know a lot about the physiology of COVID19, the pulmonary vasculature, and the right side of the heart. There are multiple physiologic and disease-related pathways that converge to produce RV-failure in patients with COVID-19 ARDS on ECMO (Sato R et al. Crit Care. 2021;25:172). Ongoing relative hypoxemia, hypercapnia, acidemia, and microvascular thromboses/immunothromboses can all lead to increased pulmonary vascular resistance (PVR) and an increased workload for the RV (Zochios V et al. ASAIO Journal. 2022; 68[4]:456). ARDS management typically involves high positive end-expiratory pressure (PEEP), which can produce RV-PA uncoupling (Wanner P et al. J Clin Med. 2020;9:432).

We do know that ECMO relieves the stress on the right side of the heart by improving hypoxemia, hypercapnia, and acidemia while allowing for reduction in PEEP (Zochios V et al. ASAIO Journal. 2022; 68[4]:456). In addition to ECMO, proning and pulmonary vasodilators offload RV by further reducing pulmonary pressures (Sato R et al. Crit Care. 2021;25:172). Lastly, a right ventricular assist device (RVAD) can dissipate the work required by the RV and prevent decompensation. Collectively, these therapies can be considered preventive.

Knowing the RV parameters on RV are sensitive but not specific for outcomes though, when should some of these treatments be instituted? It’s clear that once RV failure has developed it’s probably too late, but it’s hard to find data to guide us on when to act. One institution used right ventricular assist devices (RVADs) at the time of ECMO initiation with protocolized care and achieved a survival to discharge rate of 73% (Mustafa AK et al. JAMA Surgery. 2020;155[10]:990). The publication generated enthusiasm for RVAD support with ECMO, but it’s possible the protocolized care drove the high survival rate, at least in part.

At our institution, we developed our own protocol for evaluation of the RV with proactive treatment based on specific targets. We performed daily, bedside TTE and assessed the RV fractional area of change (FAC) and outflow tract velocity time integral (VTI). These parameters provide a quantitative assessment of global RV function, and FAC is directly related to ability to wean from ECMO support (Maharaj V et al. ASAIO Journal. 2022;68[6]:772). We avoided using the tricuspid annular plain systolic excursion (TAPSE) due to its poor sensitivity (Marra AM et al. Chest. 2022;161[2]:535). Patients receiving ECMO with subjective, global mild to moderate RV dysfunction on TTE with worsening clinical data, an FAC of 20%-35%, and a VTI of 10-14 cm were treated with aggressive diuresis, pulmonary vasodilators, and inotropy for 48 hours. If there was no improvement or deterioration, an RVAD was placed. For patients with signs of severe RV dysfunction (FAC < 20% or VTI < 10 cm), we proceeded directly to RVAD. We’re currently collecting data and tracking outcomes.

While data exist on various interventions in RV failure due to COVID-19 ARDS with ECMO, our understanding of this disease is still in its infancy. The optimal timing of interventions to manage and prevent RV failure is not known. We would argue that those who wait for RV failure to occur before instituting protective or supportive therapies are missing the opportunity to impact outcomes. We currently do not have the evidence to support the specific protocol we’ve outlined here and instituted at our hospital. However, we do believe there’s enough literature and experience to support the concept that close monitoring of RV function is critical for patients with COVID19 ARDS receiving ECMO. Failure to anticipate worsening function on the way to failure means reacting to it rather than staving it off. By then, it’s too late.
 

Dr. Thomas is Maj, USAF, assistant professor, pulmonary/critical care; Dr. O’Neil is Maj, USAF, pediatric and ECMO intensivist, PICU medical director; and Dr. Villalobos is Capt, USAF, assistant professor, pulmonary/critical care, medical ICU director, Brooke Army Medical Center, San Antonio, Tex. The view(s) expressed herein are those of the author(s) and do not reflect the official policy or position of Brooke Army Medical Center, the U.S. Army Medical Department, the U.S. Army Office of the Surgeon General, the Department of the Army, the Department of the Air Force, or the Department of Defense or the U.S. government.

The SARS-CoV-2 pandemic changed the way intensivists approach extracorporeal membrane oxygenation (ECMO). Patients with COVID-19 acute respiratory distress syndrome (ARDS) placed on ECMO have a high prevalence of right ventricular (RV) failure, which is associated with reduced survival (Maharaj V et al. ASAIO Journal. 2022;68[6]:772). In 2021, our institution supported 51 patients with COVID-19 ARDS with ECMO: 51% developed RV failure, defined as a clinical syndrome (reduced cardiac output) in the presence of RV dysfunction on transthoracic echocardiogram (TTE) (Marra A et al. Chest. 2022;161[2]:535). Total numbers for RV dysfunction and RV dilation on TTE were 78% and 91% respectively, so many of those with RV changes on TTE did not progress to clinical failure. In essence then, TTE signs of RV dysfunction are sensitive but not specific for clinical RV failure.

Rates for survival to decannulation were far lower when RV failure was present (27%) vs. absent (84%). Given these numbers, we felt a reduction in RV failure would be an important target for improving outcomes for patients with COVID-19 ARDS receiving ECMO. Existing studies on RV failure in patients with ARDS receiving ECMO are plagued by scant data, small sample sizes, differences in diagnostic criteria, and heterogenous treatment approaches. Despite these limitations, we felt the need to make changes in our approach to RV management.

Because outcomes once clinical RV-failure occurs are so poor, we focused on prevention. While we’re short on data and evidence-based medicine (EBM) here, we know a lot about the physiology of COVID19, the pulmonary vasculature, and the right side of the heart. There are multiple physiologic and disease-related pathways that converge to produce RV-failure in patients with COVID-19 ARDS on ECMO (Sato R et al. Crit Care. 2021;25:172). Ongoing relative hypoxemia, hypercapnia, acidemia, and microvascular thromboses/immunothromboses can all lead to increased pulmonary vascular resistance (PVR) and an increased workload for the RV (Zochios V et al. ASAIO Journal. 2022; 68[4]:456). ARDS management typically involves high positive end-expiratory pressure (PEEP), which can produce RV-PA uncoupling (Wanner P et al. J Clin Med. 2020;9:432).

We do know that ECMO relieves the stress on the right side of the heart by improving hypoxemia, hypercapnia, and acidemia while allowing for reduction in PEEP (Zochios V et al. ASAIO Journal. 2022; 68[4]:456). In addition to ECMO, proning and pulmonary vasodilators offload RV by further reducing pulmonary pressures (Sato R et al. Crit Care. 2021;25:172). Lastly, a right ventricular assist device (RVAD) can dissipate the work required by the RV and prevent decompensation. Collectively, these therapies can be considered preventive.

Knowing the RV parameters on RV are sensitive but not specific for outcomes though, when should some of these treatments be instituted? It’s clear that once RV failure has developed it’s probably too late, but it’s hard to find data to guide us on when to act. One institution used right ventricular assist devices (RVADs) at the time of ECMO initiation with protocolized care and achieved a survival to discharge rate of 73% (Mustafa AK et al. JAMA Surgery. 2020;155[10]:990). The publication generated enthusiasm for RVAD support with ECMO, but it’s possible the protocolized care drove the high survival rate, at least in part.

At our institution, we developed our own protocol for evaluation of the RV with proactive treatment based on specific targets. We performed daily, bedside TTE and assessed the RV fractional area of change (FAC) and outflow tract velocity time integral (VTI). These parameters provide a quantitative assessment of global RV function, and FAC is directly related to ability to wean from ECMO support (Maharaj V et al. ASAIO Journal. 2022;68[6]:772). We avoided using the tricuspid annular plain systolic excursion (TAPSE) due to its poor sensitivity (Marra AM et al. Chest. 2022;161[2]:535). Patients receiving ECMO with subjective, global mild to moderate RV dysfunction on TTE with worsening clinical data, an FAC of 20%-35%, and a VTI of 10-14 cm were treated with aggressive diuresis, pulmonary vasodilators, and inotropy for 48 hours. If there was no improvement or deterioration, an RVAD was placed. For patients with signs of severe RV dysfunction (FAC < 20% or VTI < 10 cm), we proceeded directly to RVAD. We’re currently collecting data and tracking outcomes.

While data exist on various interventions in RV failure due to COVID-19 ARDS with ECMO, our understanding of this disease is still in its infancy. The optimal timing of interventions to manage and prevent RV failure is not known. We would argue that those who wait for RV failure to occur before instituting protective or supportive therapies are missing the opportunity to impact outcomes. We currently do not have the evidence to support the specific protocol we’ve outlined here and instituted at our hospital. However, we do believe there’s enough literature and experience to support the concept that close monitoring of RV function is critical for patients with COVID19 ARDS receiving ECMO. Failure to anticipate worsening function on the way to failure means reacting to it rather than staving it off. By then, it’s too late.
 

Dr. Thomas is Maj, USAF, assistant professor, pulmonary/critical care; Dr. O’Neil is Maj, USAF, pediatric and ECMO intensivist, PICU medical director; and Dr. Villalobos is Capt, USAF, assistant professor, pulmonary/critical care, medical ICU director, Brooke Army Medical Center, San Antonio, Tex. The view(s) expressed herein are those of the author(s) and do not reflect the official policy or position of Brooke Army Medical Center, the U.S. Army Medical Department, the U.S. Army Office of the Surgeon General, the Department of the Army, the Department of the Air Force, or the Department of Defense or the U.S. government.

Since the first SARS-CoV-2 (COVID-19) outbreak in Wuhan, China, in December 2019, more than 6.6 million deaths have occurred. Management strategies for patients with COVID-19 pneumonia/ARDS have continued to evolve during the pandemic. One of the strategies for those cases refractory to traditional ARDS treatments has been the use of extracorporeal membrane oxygenation (ECMO).

Before the COVID-19 pandemic, a substantial amount of data regarding the use of ECMO in ARDS was gathered during the H1N1 influenza outbreak in 2009. Mortality ranged from 8% to 65% (Zangrillo, et al. Crit Care. 2013;17[1]:R30). From these data, we learned the importance of patient selection. Young patients with few co-morbidities and less than 7 days supported by mechanical ventilation did remarkably better than elderly patients or those who had prolonged positive-pressure ventilation prior to ECMO.  

To date, the mortality rate for COVID-19 patients with ARDS requiring ECMO is 48% based on data from ELSO. Interestingly though, using May 1, 2020, as a cutoff date, mortality rates for patients with COVID-19 receiving ECMO significantly increased from 37% to 52% (Barbaro, et al. Lancet. 2021;398[10307]:1230). This escalation in mortality engendered concern that ECMO may not be useful in treating patients with COVID-19 and ARDS.

Several factors can be cited for this increase in mortality. First, many new ECMO programs launched after May 1. These new programs had a higher mortality rate (59%) compared with established programs, suggesting that program and provider experience play a significant role in patient outcomes (Barbaro, et al. Lancet. 2021;398[10307]:1230). Second, patients in the latter part of 2020 experienced much longer intervals between the onset of symptoms and time of intubation. Clinicians had a tendency to delay intubation as long as possible. Subsequently, the number of days receiving high flow nasal oxygen or noninvasive ventilation (NIV) was significantly longer (Schmidt, et al. Crit Care. 2021;25[1]:355). These data suggest that prolonged NIV on high Fio2 may be a negative prognostic indicator and should be considered when assessing a patient’s candidacy for ECMO.

Early in the pandemic, clinicians realized that average ECMO run times for patients with COVID-19 and ARDS were significantly longer, 15 vs 9 days, respectively (Jacobs, et al. Ann Thorac Surg. 2022;113[5]:1452). With such long run times, beds were slow to turn over, and a shortage of ECMO beds resulted during the height of the pandemic. In a retrospective study, Gannon looked at 90 patients, all of whom were deemed medically appropriate for ECMO. Two groups were created: (1) no capacity for ECMO vs (2) ECMO provided. Mortality rates were staggering at 89% and 43%, respectively (P =.001) (Gannon, et al. Am J Respir Crit Care Med. 2022;205[11]:1354). This study demonstrated a profound point: during a pandemic, when demand overcomes supply, there is a unique opportunity to see the effect of lifesaving therapies, such as ECMO, on outcomes. This study was particularly poignant, as the average age of the patients was 40 years old.  

It is now widely accepted that prone positioning has survival benefit in ARDS. Prone positioning while receiving ECMO has generally been avoided due to concern for potential complications associated with the cannula(s). However, it has been shown that prone positioning while receiving veno-venous (VV) -ECMO reduces mortality rates, 37% proned vs 50% supine positioning (P =.02) (Giani, et al. Ann Am Thorac Soc. 2021;18[3]:495). In this study, no major complications occurred, and minor complications occurred in 6% of the proning events. Prone positioning improves ventilation-perfusion mismatch and reduces hypoxic vasoconstriction, which is thought to be right-sided heart-protective.  

Right-sided heart dysfunction (RHD) is common in ARDS, whether COVID-19-related or not. The pathogenesis includes hypoxic vasoconstriction, pulmonary fibrosis, and ventilator-induced lung injury. Pulmonary microthrombi and patient-specific characteristics, such as obesity, are additional factors leading to RHD in patients with COVID-19. During the pandemic, several articles described using right-sided heart protective cannulation strategies for patients with COVID-19 requiring ECMO with favorable results (Mustafa, et al. JAMA Surg. 2020;155[10]:990; Cain, et al. J Surg Res. 2021;264:81-89). This right-sided heart protective strategy involves inserting a single access dual lumen cannula into the right internal jugular vein, which is advanced into the pulmonary artery, effectively bypassing the right ventricle. This setup is more typical of right ventricle assist device (RVAD), rather than typical VV-ECMO, which returns blood to the right atrium. Unfortunately, these studies did not include echocardiographic information to evaluate the effects of this intervention on RVD, and this is an area for future research. However, this vein to pulmonary artery strategy was found to facilitate decreased sedation, earlier liberation from mechanical ventilation, reduced need for tracheostomy, improved mobilization out of bed, and ease in prone positioning (Mustafa, et al. JAMA Surg. 2020;155[10]:990).

In conclusion, there is evidence to support the use of ECMO in patients with COVID-19 patients and ARDS failing conventional mechanical ventilation. The success of ECMO therapy is highly dependent on patient selection. Prolonged use of NIV on high Fio2 may be a negative predictor of ECMO survival and should be considered when assessing a patient for ECMO candidacy. Prone positioning with ECMO has been shown to have survival benefit and should be considered in all patients receiving ECMO.
 

Dr. Gaillard, Dr. Staples, and Dr. Kapoor are with the Department of Anesthesiology, Section on Critical Care, at Wake Forest School of Medicine in Winston-Salem, N.C. Dr. Gaillard is also with the Department of Emergency Medicine and Department of Internal Medicine, Section on Pulmonary, Critical Care, Allergy, and Immunology at Wake Forest School of Medicine.

Since the first SARS-CoV-2 (COVID-19) outbreak in Wuhan, China, in December 2019, more than 6.6 million deaths have occurred. Management strategies for patients with COVID-19 pneumonia/ARDS have continued to evolve during the pandemic. One of the strategies for those cases refractory to traditional ARDS treatments has been the use of extracorporeal membrane oxygenation (ECMO).

Before the COVID-19 pandemic, a substantial amount of data regarding the use of ECMO in ARDS was gathered during the H1N1 influenza outbreak in 2009. Mortality ranged from 8% to 65% (Zangrillo, et al. Crit Care. 2013;17[1]:R30). From these data, we learned the importance of patient selection. Young patients with few co-morbidities and less than 7 days supported by mechanical ventilation did remarkably better than elderly patients or those who had prolonged positive-pressure ventilation prior to ECMO.  

To date, the mortality rate for COVID-19 patients with ARDS requiring ECMO is 48% based on data from ELSO. Interestingly though, using May 1, 2020, as a cutoff date, mortality rates for patients with COVID-19 receiving ECMO significantly increased from 37% to 52% (Barbaro, et al. Lancet. 2021;398[10307]:1230). This escalation in mortality engendered concern that ECMO may not be useful in treating patients with COVID-19 and ARDS.

Several factors can be cited for this increase in mortality. First, many new ECMO programs launched after May 1. These new programs had a higher mortality rate (59%) compared with established programs, suggesting that program and provider experience play a significant role in patient outcomes (Barbaro, et al. Lancet. 2021;398[10307]:1230). Second, patients in the latter part of 2020 experienced much longer intervals between the onset of symptoms and time of intubation. Clinicians had a tendency to delay intubation as long as possible. Subsequently, the number of days receiving high flow nasal oxygen or noninvasive ventilation (NIV) was significantly longer (Schmidt, et al. Crit Care. 2021;25[1]:355). These data suggest that prolonged NIV on high Fio2 may be a negative prognostic indicator and should be considered when assessing a patient’s candidacy for ECMO.

Early in the pandemic, clinicians realized that average ECMO run times for patients with COVID-19 and ARDS were significantly longer, 15 vs 9 days, respectively (Jacobs, et al. Ann Thorac Surg. 2022;113[5]:1452). With such long run times, beds were slow to turn over, and a shortage of ECMO beds resulted during the height of the pandemic. In a retrospective study, Gannon looked at 90 patients, all of whom were deemed medically appropriate for ECMO. Two groups were created: (1) no capacity for ECMO vs (2) ECMO provided. Mortality rates were staggering at 89% and 43%, respectively (P =.001) (Gannon, et al. Am J Respir Crit Care Med. 2022;205[11]:1354). This study demonstrated a profound point: during a pandemic, when demand overcomes supply, there is a unique opportunity to see the effect of lifesaving therapies, such as ECMO, on outcomes. This study was particularly poignant, as the average age of the patients was 40 years old.  

It is now widely accepted that prone positioning has survival benefit in ARDS. Prone positioning while receiving ECMO has generally been avoided due to concern for potential complications associated with the cannula(s). However, it has been shown that prone positioning while receiving veno-venous (VV) -ECMO reduces mortality rates, 37% proned vs 50% supine positioning (P =.02) (Giani, et al. Ann Am Thorac Soc. 2021;18[3]:495). In this study, no major complications occurred, and minor complications occurred in 6% of the proning events. Prone positioning improves ventilation-perfusion mismatch and reduces hypoxic vasoconstriction, which is thought to be right-sided heart-protective.  

Right-sided heart dysfunction (RHD) is common in ARDS, whether COVID-19-related or not. The pathogenesis includes hypoxic vasoconstriction, pulmonary fibrosis, and ventilator-induced lung injury. Pulmonary microthrombi and patient-specific characteristics, such as obesity, are additional factors leading to RHD in patients with COVID-19. During the pandemic, several articles described using right-sided heart protective cannulation strategies for patients with COVID-19 requiring ECMO with favorable results (Mustafa, et al. JAMA Surg. 2020;155[10]:990; Cain, et al. J Surg Res. 2021;264:81-89). This right-sided heart protective strategy involves inserting a single access dual lumen cannula into the right internal jugular vein, which is advanced into the pulmonary artery, effectively bypassing the right ventricle. This setup is more typical of right ventricle assist device (RVAD), rather than typical VV-ECMO, which returns blood to the right atrium. Unfortunately, these studies did not include echocardiographic information to evaluate the effects of this intervention on RVD, and this is an area for future research. However, this vein to pulmonary artery strategy was found to facilitate decreased sedation, earlier liberation from mechanical ventilation, reduced need for tracheostomy, improved mobilization out of bed, and ease in prone positioning (Mustafa, et al. JAMA Surg. 2020;155[10]:990).

In conclusion, there is evidence to support the use of ECMO in patients with COVID-19 patients and ARDS failing conventional mechanical ventilation. The success of ECMO therapy is highly dependent on patient selection. Prolonged use of NIV on high Fio2 may be a negative predictor of ECMO survival and should be considered when assessing a patient for ECMO candidacy. Prone positioning with ECMO has been shown to have survival benefit and should be considered in all patients receiving ECMO.
 

Dr. Gaillard, Dr. Staples, and Dr. Kapoor are with the Department of Anesthesiology, Section on Critical Care, at Wake Forest School of Medicine in Winston-Salem, N.C. Dr. Gaillard is also with the Department of Emergency Medicine and Department of Internal Medicine, Section on Pulmonary, Critical Care, Allergy, and Immunology at Wake Forest School of Medicine.

Since the first SARS-CoV-2 (COVID-19) outbreak in Wuhan, China, in December 2019, more than 6.6 million deaths have occurred. Management strategies for patients with COVID-19 pneumonia/ARDS have continued to evolve during the pandemic. One of the strategies for those cases refractory to traditional ARDS treatments has been the use of extracorporeal membrane oxygenation (ECMO).

Before the COVID-19 pandemic, a substantial amount of data regarding the use of ECMO in ARDS was gathered during the H1N1 influenza outbreak in 2009. Mortality ranged from 8% to 65% (Zangrillo, et al. Crit Care. 2013;17[1]:R30). From these data, we learned the importance of patient selection. Young patients with few co-morbidities and less than 7 days supported by mechanical ventilation did remarkably better than elderly patients or those who had prolonged positive-pressure ventilation prior to ECMO.  

To date, the mortality rate for COVID-19 patients with ARDS requiring ECMO is 48% based on data from ELSO. Interestingly though, using May 1, 2020, as a cutoff date, mortality rates for patients with COVID-19 receiving ECMO significantly increased from 37% to 52% (Barbaro, et al. Lancet. 2021;398[10307]:1230). This escalation in mortality engendered concern that ECMO may not be useful in treating patients with COVID-19 and ARDS.

Several factors can be cited for this increase in mortality. First, many new ECMO programs launched after May 1. These new programs had a higher mortality rate (59%) compared with established programs, suggesting that program and provider experience play a significant role in patient outcomes (Barbaro, et al. Lancet. 2021;398[10307]:1230). Second, patients in the latter part of 2020 experienced much longer intervals between the onset of symptoms and time of intubation. Clinicians had a tendency to delay intubation as long as possible. Subsequently, the number of days receiving high flow nasal oxygen or noninvasive ventilation (NIV) was significantly longer (Schmidt, et al. Crit Care. 2021;25[1]:355). These data suggest that prolonged NIV on high Fio2 may be a negative prognostic indicator and should be considered when assessing a patient’s candidacy for ECMO.

Early in the pandemic, clinicians realized that average ECMO run times for patients with COVID-19 and ARDS were significantly longer, 15 vs 9 days, respectively (Jacobs, et al. Ann Thorac Surg. 2022;113[5]:1452). With such long run times, beds were slow to turn over, and a shortage of ECMO beds resulted during the height of the pandemic. In a retrospective study, Gannon looked at 90 patients, all of whom were deemed medically appropriate for ECMO. Two groups were created: (1) no capacity for ECMO vs (2) ECMO provided. Mortality rates were staggering at 89% and 43%, respectively (P =.001) (Gannon, et al. Am J Respir Crit Care Med. 2022;205[11]:1354). This study demonstrated a profound point: during a pandemic, when demand overcomes supply, there is a unique opportunity to see the effect of lifesaving therapies, such as ECMO, on outcomes. This study was particularly poignant, as the average age of the patients was 40 years old.  

It is now widely accepted that prone positioning has survival benefit in ARDS. Prone positioning while receiving ECMO has generally been avoided due to concern for potential complications associated with the cannula(s). However, it has been shown that prone positioning while receiving veno-venous (VV) -ECMO reduces mortality rates, 37% proned vs 50% supine positioning (P =.02) (Giani, et al. Ann Am Thorac Soc. 2021;18[3]:495). In this study, no major complications occurred, and minor complications occurred in 6% of the proning events. Prone positioning improves ventilation-perfusion mismatch and reduces hypoxic vasoconstriction, which is thought to be right-sided heart-protective.  

Right-sided heart dysfunction (RHD) is common in ARDS, whether COVID-19-related or not. The pathogenesis includes hypoxic vasoconstriction, pulmonary fibrosis, and ventilator-induced lung injury. Pulmonary microthrombi and patient-specific characteristics, such as obesity, are additional factors leading to RHD in patients with COVID-19. During the pandemic, several articles described using right-sided heart protective cannulation strategies for patients with COVID-19 requiring ECMO with favorable results (Mustafa, et al. JAMA Surg. 2020;155[10]:990; Cain, et al. J Surg Res. 2021;264:81-89). This right-sided heart protective strategy involves inserting a single access dual lumen cannula into the right internal jugular vein, which is advanced into the pulmonary artery, effectively bypassing the right ventricle. This setup is more typical of right ventricle assist device (RVAD), rather than typical VV-ECMO, which returns blood to the right atrium. Unfortunately, these studies did not include echocardiographic information to evaluate the effects of this intervention on RVD, and this is an area for future research. However, this vein to pulmonary artery strategy was found to facilitate decreased sedation, earlier liberation from mechanical ventilation, reduced need for tracheostomy, improved mobilization out of bed, and ease in prone positioning (Mustafa, et al. JAMA Surg. 2020;155[10]:990).

In conclusion, there is evidence to support the use of ECMO in patients with COVID-19 patients and ARDS failing conventional mechanical ventilation. The success of ECMO therapy is highly dependent on patient selection. Prolonged use of NIV on high Fio2 may be a negative predictor of ECMO survival and should be considered when assessing a patient for ECMO candidacy. Prone positioning with ECMO has been shown to have survival benefit and should be considered in all patients receiving ECMO.
 

Dr. Gaillard, Dr. Staples, and Dr. Kapoor are with the Department of Anesthesiology, Section on Critical Care, at Wake Forest School of Medicine in Winston-Salem, N.C. Dr. Gaillard is also with the Department of Emergency Medicine and Department of Internal Medicine, Section on Pulmonary, Critical Care, Allergy, and Immunology at Wake Forest School of Medicine.

Diffuse Lung Disease & Transplant Network

Interstitial Lung Disease Section

Delay in diagnosis of IPF: How bad is the problem?

Idiopathic pulmonary fibrosis (IPF) is a devastating disease with a poor prognosis. Antifibrotic therapies for IPF are only capable of slowing disease progression without reversing established fibrosis. As such, the therapeutic efficacy of antifibrotic therapy may be reduced in patients whose diagnosis is delayed.

Unfortunately, diagnostic delay is common in IPF. Studies demonstrate that IPF diagnosis is delayed by more than a year after symptom onset in 43% of subjects, and more than 3 years in 19% of subjects (Cosgrove GP et al. BMC Pulm Med. 2018;18[9]). Approximately one-third of patients with IPF have undergone chest CT imaging more than 3 years prior to diagnosis, and around the same proportion has seen a pulmonologist within the same time span (Mooney J, et al. Ann Am Thorac Soc. 2019;16[3]:393). A median delay to IPF diagnosis of 2.2 years was noted in patients presenting to a tertiary academic medical center and was associated with an increased risk of death independent of age, sex, and forced vital capacity (adjusted hazard ratio per doubling of delay was 1.3) (Lamas DJ et al. Am J Respir Crit Care Med. 2011;184:842).

Robust improvements are clearly required for identifying patients with IPF earlier in their disease course. The Bridging Specialties Initiative from CHEST and the Three Lakes Foundation is one resource designed to improve the timely diagnosis of ILD (ILD Clinician Toolkit available at https://www.chestnet.org/Guidelines-and-Topic-Collections/Bridging-Specialties/Timely-Diagnosis-for-ILD-Patients/Clinician-Toolkit). This, and other initiatives will hopefully reduce delays in diagnosing IPF, allowing for optimal patient care.

Adrian Shifren, MBBCh, FCCP, Member-at-Large

Saniya Khan, MD, MBBS, Member-at-Large

Robert Case Jr., MD, Pulmonary & Critical Care Fellow
 

Critical Care Network

Mechanical Ventilation and Airways Section

Noninvasive ventilation

Noninvasive ventilation (NIV) is a ventilation modality that supports breathing by using mechanically assisted breaths without the need for intubation or a surgical airway. NIV is divided into two main types, negative-pressure ventilation (NPV) and noninvasive positive-pressure ventilation (NIPPV).

NPV

NPV periodically generates a negative (subatmospheric) pressure on the thorax wall, reflecting the natural breathing mechanism. As this negative pressure is transmitted into the thorax, normal atmospheric pressure air outside the thorax is pulled in for inhalation. Initiated by the negative pressure generator switching off, exhalation is passive due to elastic recoil of the lung and chest wall. The iron lung was a neck-to-toe horizontal cylinder used for NPV during the polio epidemic. New NPV devices are designed to fit the thorax only, using a cuirass (a torso-covering body armor molded shell).

For years, NPV use declined as NIPPV use increased. However, during the shortage of NIPPV devices during COVID and a recent recall of certain CPAP devices, NPV use has increased. NPV is an excellent alternative for those who cannot tolerate a facial mask due to facial deformity, claustrophobia, or excessive airway secretion (Corrado A et al. European Resp J. 2002;20[1]:187).
 

NIPPV

NIPPV is divided into several subtypes, including continuous positive airway pressure (CPAP), bilevel positive airway pressure (BPAP or BiPAP), and average volume-assured pressure support (AVAPS or VAPS). CPAP is defined as a single pressure delivered in inhalation (Pi) and exhalation (Pe). The increased mean airway pressure provides improved oxygenation (O₂) but not ventilation (CO₂). BPAP uses dual pressures with Pi higher than Pe. The increased mean airway pressure provides improved O₂ while the difference between Pi minus Pe increases ventilation and decreases CO₂.

AVAPS is a form of BPAP where Pi varies in an automated range to achieve the ordered tidal volume. In AVAPS, the generator adjusts Pi based on the average delivered tidal volume. If the average delivered tidal volume is less than the set tidal volume, Pi gradually increases while not exceeding Pi Max. Patients notice improved comfort of AVAPS with a variable Pi vs. BPAP with a fixed Pi (Frank A et al. Chest. 2018;154[4]:1060A).

Samantha Tauscher, DO, Resident-in-Training

Herbert Patrick, MD, MSEE, FCCP , Member-at-Large
 

Pulmonary Vascular & Cardiovascular Disease Network

Pulmonary Vascular Disease Section

A RACE to the finish: Revisiting the role of BPA in the management of CTEPH

Pulmonary thromboendarterectomy (PTE) is the treatment of choice for patients with CTEPH (Kim NH et al. Eur Respir J. 2019;53:1801915). However, this leaves about 40% of CTEPH patients who are not operative candidates due to inaccessible distal clot burden or significant comorbidities (Pepke-Zaba J et al. Circulation 2011;124:1973). For these inoperable situations, riociguat is the only FDA-approved medical therapy (Delcroix M et al. Eur Respir J. 2021;57:2002828). Balloon pulmonary angioplasty (BPA) became a treatment option for these patients in the last 2 decades. As technique refined, BPA demonstrated improved safety data along with improved hemodynamics and increased exercise capacity (Kataoka M et al. Circ Cardiovasc Interv. 2012;5:756).

A recently published crossover study, the RACE trial, compared riociguat with BPA in treating inoperable CTEPH (Jaïs X et al. Lancet Respir Med. 2022;10[10]:961). Patients were randomly assigned to either riociguat or BPA for 26 weeks. At 26 weeks, patients with pulmonary vascular resistance (PVR) more than 4 Woods Units (WU) were crossed over to receive either BPA or riociguat therapy. At 26 weeks, the BPA arm showed a greater reduction in PVR but more complications, including lung injury and hemoptysis. After a 26-week crossover period, the reduction in PVR was similar in both arms. The complication rate in the BPA arm was lower when preceded by riociguat.

In patients with inoperable CTEPH, BPA has emerged as an attractive management option in addition to the medical therapy with riociguat. However, BPA should be performed at expert centers with experience. Further studies are needed to strengthen the role and optimal timing of BPA in management of post PTE patients with residual PH.

Samantha Pettigrew, MD, Fellow-in-Training

Janine Vintich, MD, FCCP, Member-at-Large

Diffuse Lung Disease & Transplant Network

Interstitial Lung Disease Section

Delay in diagnosis of IPF: How bad is the problem?

Idiopathic pulmonary fibrosis (IPF) is a devastating disease with a poor prognosis. Antifibrotic therapies for IPF are only capable of slowing disease progression without reversing established fibrosis. As such, the therapeutic efficacy of antifibrotic therapy may be reduced in patients whose diagnosis is delayed.

Unfortunately, diagnostic delay is common in IPF. Studies demonstrate that IPF diagnosis is delayed by more than a year after symptom onset in 43% of subjects, and more than 3 years in 19% of subjects (Cosgrove GP et al. BMC Pulm Med. 2018;18[9]). Approximately one-third of patients with IPF have undergone chest CT imaging more than 3 years prior to diagnosis, and around the same proportion has seen a pulmonologist within the same time span (Mooney J, et al. Ann Am Thorac Soc. 2019;16[3]:393). A median delay to IPF diagnosis of 2.2 years was noted in patients presenting to a tertiary academic medical center and was associated with an increased risk of death independent of age, sex, and forced vital capacity (adjusted hazard ratio per doubling of delay was 1.3) (Lamas DJ et al. Am J Respir Crit Care Med. 2011;184:842).

Robust improvements are clearly required for identifying patients with IPF earlier in their disease course. The Bridging Specialties Initiative from CHEST and the Three Lakes Foundation is one resource designed to improve the timely diagnosis of ILD (ILD Clinician Toolkit available at https://www.chestnet.org/Guidelines-and-Topic-Collections/Bridging-Specialties/Timely-Diagnosis-for-ILD-Patients/Clinician-Toolkit). This, and other initiatives will hopefully reduce delays in diagnosing IPF, allowing for optimal patient care.

Adrian Shifren, MBBCh, FCCP, Member-at-Large

Saniya Khan, MD, MBBS, Member-at-Large

Robert Case Jr., MD, Pulmonary & Critical Care Fellow
 

Critical Care Network

Mechanical Ventilation and Airways Section

Noninvasive ventilation

Noninvasive ventilation (NIV) is a ventilation modality that supports breathing by using mechanically assisted breaths without the need for intubation or a surgical airway. NIV is divided into two main types, negative-pressure ventilation (NPV) and noninvasive positive-pressure ventilation (NIPPV).

NPV

NPV periodically generates a negative (subatmospheric) pressure on the thorax wall, reflecting the natural breathing mechanism. As this negative pressure is transmitted into the thorax, normal atmospheric pressure air outside the thorax is pulled in for inhalation. Initiated by the negative pressure generator switching off, exhalation is passive due to elastic recoil of the lung and chest wall. The iron lung was a neck-to-toe horizontal cylinder used for NPV during the polio epidemic. New NPV devices are designed to fit the thorax only, using a cuirass (a torso-covering body armor molded shell).

For years, NPV use declined as NIPPV use increased. However, during the shortage of NIPPV devices during COVID and a recent recall of certain CPAP devices, NPV use has increased. NPV is an excellent alternative for those who cannot tolerate a facial mask due to facial deformity, claustrophobia, or excessive airway secretion (Corrado A et al. European Resp J. 2002;20[1]:187).
 

NIPPV

NIPPV is divided into several subtypes, including continuous positive airway pressure (CPAP), bilevel positive airway pressure (BPAP or BiPAP), and average volume-assured pressure support (AVAPS or VAPS). CPAP is defined as a single pressure delivered in inhalation (Pi) and exhalation (Pe). The increased mean airway pressure provides improved oxygenation (O₂) but not ventilation (CO₂). BPAP uses dual pressures with Pi higher than Pe. The increased mean airway pressure provides improved O₂ while the difference between Pi minus Pe increases ventilation and decreases CO₂.

AVAPS is a form of BPAP where Pi varies in an automated range to achieve the ordered tidal volume. In AVAPS, the generator adjusts Pi based on the average delivered tidal volume. If the average delivered tidal volume is less than the set tidal volume, Pi gradually increases while not exceeding Pi Max. Patients notice improved comfort of AVAPS with a variable Pi vs. BPAP with a fixed Pi (Frank A et al. Chest. 2018;154[4]:1060A).

Samantha Tauscher, DO, Resident-in-Training

Herbert Patrick, MD, MSEE, FCCP , Member-at-Large
 

Pulmonary Vascular & Cardiovascular Disease Network

Pulmonary Vascular Disease Section

A RACE to the finish: Revisiting the role of BPA in the management of CTEPH

Pulmonary thromboendarterectomy (PTE) is the treatment of choice for patients with CTEPH (Kim NH et al. Eur Respir J. 2019;53:1801915). However, this leaves about 40% of CTEPH patients who are not operative candidates due to inaccessible distal clot burden or significant comorbidities (Pepke-Zaba J et al. Circulation 2011;124:1973). For these inoperable situations, riociguat is the only FDA-approved medical therapy (Delcroix M et al. Eur Respir J. 2021;57:2002828). Balloon pulmonary angioplasty (BPA) became a treatment option for these patients in the last 2 decades. As technique refined, BPA demonstrated improved safety data along with improved hemodynamics and increased exercise capacity (Kataoka M et al. Circ Cardiovasc Interv. 2012;5:756).

A recently published crossover study, the RACE trial, compared riociguat with BPA in treating inoperable CTEPH (Jaïs X et al. Lancet Respir Med. 2022;10[10]:961). Patients were randomly assigned to either riociguat or BPA for 26 weeks. At 26 weeks, patients with pulmonary vascular resistance (PVR) more than 4 Woods Units (WU) were crossed over to receive either BPA or riociguat therapy. At 26 weeks, the BPA arm showed a greater reduction in PVR but more complications, including lung injury and hemoptysis. After a 26-week crossover period, the reduction in PVR was similar in both arms. The complication rate in the BPA arm was lower when preceded by riociguat.

In patients with inoperable CTEPH, BPA has emerged as an attractive management option in addition to the medical therapy with riociguat. However, BPA should be performed at expert centers with experience. Further studies are needed to strengthen the role and optimal timing of BPA in management of post PTE patients with residual PH.

Samantha Pettigrew, MD, Fellow-in-Training

Janine Vintich, MD, FCCP, Member-at-Large

Diffuse Lung Disease & Transplant Network

Interstitial Lung Disease Section

Delay in diagnosis of IPF: How bad is the problem?

Idiopathic pulmonary fibrosis (IPF) is a devastating disease with a poor prognosis. Antifibrotic therapies for IPF are only capable of slowing disease progression without reversing established fibrosis. As such, the therapeutic efficacy of antifibrotic therapy may be reduced in patients whose diagnosis is delayed.

Unfortunately, diagnostic delay is common in IPF. Studies demonstrate that IPF diagnosis is delayed by more than a year after symptom onset in 43% of subjects, and more than 3 years in 19% of subjects (Cosgrove GP et al. BMC Pulm Med. 2018;18[9]). Approximately one-third of patients with IPF have undergone chest CT imaging more than 3 years prior to diagnosis, and around the same proportion has seen a pulmonologist within the same time span (Mooney J, et al. Ann Am Thorac Soc. 2019;16[3]:393). A median delay to IPF diagnosis of 2.2 years was noted in patients presenting to a tertiary academic medical center and was associated with an increased risk of death independent of age, sex, and forced vital capacity (adjusted hazard ratio per doubling of delay was 1.3) (Lamas DJ et al. Am J Respir Crit Care Med. 2011;184:842).

Robust improvements are clearly required for identifying patients with IPF earlier in their disease course. The Bridging Specialties Initiative from CHEST and the Three Lakes Foundation is one resource designed to improve the timely diagnosis of ILD (ILD Clinician Toolkit available at https://www.chestnet.org/Guidelines-and-Topic-Collections/Bridging-Specialties/Timely-Diagnosis-for-ILD-Patients/Clinician-Toolkit). This, and other initiatives will hopefully reduce delays in diagnosing IPF, allowing for optimal patient care.

Adrian Shifren, MBBCh, FCCP, Member-at-Large

Saniya Khan, MD, MBBS, Member-at-Large

Robert Case Jr., MD, Pulmonary & Critical Care Fellow
 

Critical Care Network

Mechanical Ventilation and Airways Section

Noninvasive ventilation

Noninvasive ventilation (NIV) is a ventilation modality that supports breathing by using mechanically assisted breaths without the need for intubation or a surgical airway. NIV is divided into two main types, negative-pressure ventilation (NPV) and noninvasive positive-pressure ventilation (NIPPV).

NPV

NPV periodically generates a negative (subatmospheric) pressure on the thorax wall, reflecting the natural breathing mechanism. As this negative pressure is transmitted into the thorax, normal atmospheric pressure air outside the thorax is pulled in for inhalation. Initiated by the negative pressure generator switching off, exhalation is passive due to elastic recoil of the lung and chest wall. The iron lung was a neck-to-toe horizontal cylinder used for NPV during the polio epidemic. New NPV devices are designed to fit the thorax only, using a cuirass (a torso-covering body armor molded shell).

For years, NPV use declined as NIPPV use increased. However, during the shortage of NIPPV devices during COVID and a recent recall of certain CPAP devices, NPV use has increased. NPV is an excellent alternative for those who cannot tolerate a facial mask due to facial deformity, claustrophobia, or excessive airway secretion (Corrado A et al. European Resp J. 2002;20[1]:187).
 

NIPPV

NIPPV is divided into several subtypes, including continuous positive airway pressure (CPAP), bilevel positive airway pressure (BPAP or BiPAP), and average volume-assured pressure support (AVAPS or VAPS). CPAP is defined as a single pressure delivered in inhalation (Pi) and exhalation (Pe). The increased mean airway pressure provides improved oxygenation (O₂) but not ventilation (CO₂). BPAP uses dual pressures with Pi higher than Pe. The increased mean airway pressure provides improved O₂ while the difference between Pi minus Pe increases ventilation and decreases CO₂.

AVAPS is a form of BPAP where Pi varies in an automated range to achieve the ordered tidal volume. In AVAPS, the generator adjusts Pi based on the average delivered tidal volume. If the average delivered tidal volume is less than the set tidal volume, Pi gradually increases while not exceeding Pi Max. Patients notice improved comfort of AVAPS with a variable Pi vs. BPAP with a fixed Pi (Frank A et al. Chest. 2018;154[4]:1060A).

Samantha Tauscher, DO, Resident-in-Training

Herbert Patrick, MD, MSEE, FCCP , Member-at-Large
 

Pulmonary Vascular & Cardiovascular Disease Network

Pulmonary Vascular Disease Section

A RACE to the finish: Revisiting the role of BPA in the management of CTEPH

Pulmonary thromboendarterectomy (PTE) is the treatment of choice for patients with CTEPH (Kim NH et al. Eur Respir J. 2019;53:1801915). However, this leaves about 40% of CTEPH patients who are not operative candidates due to inaccessible distal clot burden or significant comorbidities (Pepke-Zaba J et al. Circulation 2011;124:1973). For these inoperable situations, riociguat is the only FDA-approved medical therapy (Delcroix M et al. Eur Respir J. 2021;57:2002828). Balloon pulmonary angioplasty (BPA) became a treatment option for these patients in the last 2 decades. As technique refined, BPA demonstrated improved safety data along with improved hemodynamics and increased exercise capacity (Kataoka M et al. Circ Cardiovasc Interv. 2012;5:756).

A recently published crossover study, the RACE trial, compared riociguat with BPA in treating inoperable CTEPH (Jaïs X et al. Lancet Respir Med. 2022;10[10]:961). Patients were randomly assigned to either riociguat or BPA for 26 weeks. At 26 weeks, patients with pulmonary vascular resistance (PVR) more than 4 Woods Units (WU) were crossed over to receive either BPA or riociguat therapy. At 26 weeks, the BPA arm showed a greater reduction in PVR but more complications, including lung injury and hemoptysis. After a 26-week crossover period, the reduction in PVR was similar in both arms. The complication rate in the BPA arm was lower when preceded by riociguat.

In patients with inoperable CTEPH, BPA has emerged as an attractive management option in addition to the medical therapy with riociguat. However, BPA should be performed at expert centers with experience. Further studies are needed to strengthen the role and optimal timing of BPA in management of post PTE patients with residual PH.

Samantha Pettigrew, MD, Fellow-in-Training

Janine Vintich, MD, FCCP, Member-at-Large

CHEST FOUNDATION GRANT AWARDS

CHEST Foundation Research Grant in Women’s Lung Health Disparities

Laura Sanapo, MD, The Miriam Hospital, Providence, R.I.

This grant is jointly supported by the CHEST Foundation and the Respiratory Health Association.



CHEST Foundation Research Grant in Chronic Obstructive Pulmonary Disease

Benjamin Wu, MD, New York University

This grant is supported by AstraZeneca.



CHEST Foundation Research Grant in Chronic Obstructive Pulmonary Disease

Richard Zou, MD, University of Pittsburgh Medical Center

This grant is supported by the CHEST Foundation.



CHEST Foundation and AASM Foundation Research Grant in Sleep Medicine

Gonzalo Labarca, MD, Universidad San Sebastian, Concepción, Chile

This grant is jointly supported by the CHEST Foundation and AASM Foundation.



CHEST Foundation and American Academy of Dental Sleep Medicine Research Grant in Sleep Apnea

Sherri Katz, MD, FCCP, Children’s Hospital of Eastern Ontario, Ottawa

This grant is supported by the CHEST Foundation and American Academy of Dental Sleep Medicine.



CHEST Foundation Research Grant in Sleep Medicine

Nancy Stewart, DO, University of Kansas Medical Center, Kansas City

This grant is supported by Jazz Pharmaceuticals.



CHEST Foundation Research Grant in Severe Asthma

Gareth Walters, MD, University Hospitals Birmingham (England)

This grant is supported by AstraZeneca.

CHEST Foundation Research Grant in Severe Asthma

Andréanne Côté, MD, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec

This grant is supported by AstraZeneca.



CHEST Foundation and APCCMPD Research Grant in Medical Education

Christopher Leba, MD, MPH, University of California, San Francisco

This grant is jointly supported by the CHEST Foundation and APCCMPD.



CHEST Foundation Research Grant in COVID-19

Clea Barnett, MD, New York University

This grant is supported by the CHEST Foundation.



CHEST Foundation Research Grant in Critical Care

Katherine Walker, MD, Brigham and Women’s Hospital, Harvard Medical School, Boston

This grant is supported by the CHEST Foundation.

CHEST Foundation Research Grant in Venous Thromboembolism

Daniel Lachant, DO, University of Rochester (N.Y.) Medical Center/Strong Memorial Hospital

This grant is supported by the CHEST Foundation.



CHEST Foundation Research Grant in Pulmonary Hypertension

Christina Thornton, MD, PhD, University of Calgary (Alta.)

This grant is supported by the CHEST Foundation.



CHEST Foundation Research Grant in Pulmonary Fibrosis

Christina Eckhardt, MD, Columbia University, New York

This grant is supported by an independent grant from Boehringer Ingelheim Pharmaceuticals and Genentech.



CHEST Foundation Research Grant in Pulmonary Fibrosis

John Kim, MD, University of Virginia, Charlottesville

This grant is supported by an independent grant from Boehringer Ingelheim Pharmaceuticals and Genentech.



John R. Addrizzo, MD, FCCP Research Grant in Sarcoidosis

Kerry Hena, MD, New York University

This grant is in honor of John R. Addrizzo, MD, FCCP and is jointly supported by the Addrizzo family and the CHEST Foundation.



CHEST Foundation Research Grant in Pediatric Lung Health

Adam Shapiro, MD, McGill University Health Centre, Montreal

This grant is supported by the CHEST Foundation.



CHEST Foundation Young Investigator Grant

Sameer Avasarala, MD, Case Western Reserve University, Cleveland

This grant is supported by the CHEST Foundation.



CHEST/ALA/ATS Respiratory Health Equity Research Award

Matthew Triplette, MD, Fred Hutchinson Cancer Research Center, Seattle

The Respiratory Health Equity Research Award is jointly supported by the American Lung Association, the American Thoracic Society, and the CHEST Foundation.



CHEST/ALA/ATS Respiratory Health Equity Research Award

Ayobami Akenroye, MD, MPH, Brigham and Women’s Hospital, Boston

The Respiratory Health Equity Research Award is jointly supported by the American Lung Association, the American Thoracic Society, and the CHEST Foundation.



CHEST Foundation Community Service Grant Honoring D. Robert McCaffree, MD, Master FCCP

Lorriane Odhiambo, PhD, Augusta (Ga.) University

This grant is supported by the CHEST Foundation.



CHEST Foundation Community Service Grant Honoring D. Robert McCaffree, MD, Master FCCP

Katie Stevens, Team Telomere, New York

This grant is supported by the CHEST Foundation.



CHEST Foundation Community Service Grant Honoring D. Robert McCaffree, MD, Master FCCP

Matthew Sharpe, MD, The University of Kansas Medical Center, Kansas City

This grant is supported by the CHEST Foundation.
 

SCIENTIFIC ABSTRACT AWARDS

Alfred Soffer Research Awards

Presented abstracts will be judged by session moderators, and award recipients will be selected for their outstanding original scientific research. Finalists will be evaluated on the basis of their written abstract and the quality of their oral presentation. This award is named in honor of Alfred Soffer, MD, Master FCCP, who was Editor in Chief of the journal CHEST® from 1968 to 1993, and Executive Director of CHEST from 1969 to 1992.



Young Investigator Awards

Investigators who are enrolled in a training or fellowship program or who have completed a fellowship program within 5 years prior to CHEST 2022 are eligible for Young Investigator Awards.

Presenters will be evaluated on the basis of their written abstract and presentation. Recipients will be selected by judges from the Scientific Presentations and Awards Committee for their outstanding original scientific research.

Top Rapid Fire Abstract Award

Awards are granted to two presenters from all the rapid fire sessions at the CHEST Annual Meeting for outstanding original scientific research and presentation



Top Case Report Award

Awards are granted to one presenter in each oral case report session at the CHEST Annual Meeting for outstanding original scientific research and presentation



Top Rapid Fire Case Report Award

Awards are granted to one presenter in each rapid fire oral case report session at the CHEST Annual Meeting for outstanding original scientific research and presentation

 

ALFRED SOFFER RESEARCH AWARD WINNERS

Palak Rath, MD

A Sense Of Urgency: Boarding Of Critical Care Medicine Patients In The ED

Syed Nazeer Mahmood, MD

Quantifying The Risk For Overtreatment And Undertreatment Of Severe Community Onset Pneumonia
 

YOUNG INVESTIGATOR AWARD WINNERS

Anusha Devarajan, MD, MBBS

Pneumomediastinum And Pneumothorax In COVID-19 Pneumonia: A Matched Case-Control Study

Marjan Islam, MD

Thoracic Ultrasound In COVID-19: Use Of Lung And Diaphragm Ultrasound In Evaluating Dyspnea In Survivors Of Critical Illness From COVID-19 Pneumonia In A Post-ICU Clinic

Aaron St Laurent, MD

Duchenne Muscular Dystrophy Respiratory Profiles From Real-World Registry Data: A Retrospective Longitudinal Study
 

ABSTRACT RAPID FIRE WINNERS

Andrew J.O. Davis, MD

Early Gas Exchange Parameters Not Associated With Survival In COVID-19-Associated ARDS Patients Requiring Prolonged Venovenous Extracorporeal Membrane Oxygenation

Benjamin Emmanuel

Clinical Outcomes In Patients With Severe Asthma Who Had Or Had Not Initiated Biologic Therapy: Results From The CLEAR Study
 

CASE REPORT SESSION WINNERS

Sathya Alekhya Bukkuri

Smarca4-Deficient Undifferentiated Tumor: A Rare Thoracic Malignancy

Zachary A. Banbury, MD

Fungal Aortitis In A Patient For Whom Blood Transfusion Is Not An Option: A Rare But Potentially Fatal Complication Of Aortic Valve Replacement

Harinivaas Shanmugavel Geetha, MD

Respiratory Distress After Potentially Fatal Aspirin Overdose: When To Intubate?

Lisa Hayes

Systemic Epstein-Barr Virus-Related T-Cell Lymphoproliferative Disorder: A Rare Cause Of Dyspnea And Pulmonary Infiltrates In An Immunocompetent Adult

Mohammed Alsaggaf, MBBS

Calcium Oxalate Deposition In Pulmonary Aspergillosis

Cheyenne Snavely

Traffic Jam In The Vasculature: A Case Of Pulmonary Leukostasis

Clarissa Smith, MD

Talcoma In Lung Cancer Screening: A Rare Benign Cause Of PET Scan Avidity

Nitin Gupta, MD

The Clue Is In The Blood Gas: A Rare Manifestation Of Lactic Acidosis

Moses Hayrabedian, MD

A Century-Old Infection Mimicking Malignancy: A Case Of Diffuse Histoplasmosis

Gabriel R. Schroeder, MD

A Case Of Wind-Instrument Associated Hypersensitivity Pneumonitis

Fizza Sajid, DO

Leaping From Lush Tropical Environments To The L-Train: A Case Of Severe Leptospirosis In New York City

Krista R. Dollar, MD

Looking Past The Ground Glass: It Was Only Skin Deep

Konstantin Golubykh, MD

Point-Of-Care Ultrasound In The Timely Diagnosis Of Colonic Necrosis

Arsal Tharwani

Abdominal Compression In End-Stage Fibrotic Interstitial Lung Disease (ILD) Improves Respiratory Compliance

Ryan Kozloski

When Asthma Isn’t: Multispecialty Approach To Fibrosing Mediastinitis

Zach S. Jarrett, DO

Vanishing Cancer: A Case Of Smoking-Related Organizing Pneumonia

Stephen Simeone

Intravascular Papillary Endothelial Hyperplasia Presenting As Thrombus In Transit With Acute Pulmonary Embolism

David Gruen, MD

Tackling Posterior Reversible Encephalopathy Syndrome (PRES): A Rare Case Of Subtherapeutic Tacrolimus Causing PRES In Steroid-Resistant Nephropathy

Nicholas Kunce, MD

An Unusual Case Of Subacute Bacterial Endocarditis Presenting With Catastrophic Subarachnoid Hemorrhage

Phillip J. Gary, MD

Sarcoid-Like Reaction After Treatment With Pembrolizumab

Shreya Podder, MD

Endobronchial Valves For Treatment Of Persistent Air Leak After Secondary Spontaneous Pneumothorax In Patients With Cystic Fibrosis

Alina Aw Wasim, MD, MBBS

Chest-Wall Castleman Disease Mimicking Thymoma Drop Metastasis

Ndausung Udongwo

The ‘Rat Bite Sign” On Cardiac MRI: Left Dominant Arrhythmogenic Cardiomyopathy As An Atypical Etiology Of Sudden Cardiac Arrest

Grant Senyei, MD

Management Of Ventriculopleural Shunt-Associated Pleural Effusion

Garima Singh, MD

COVID-19-Associated Thrombotic Thrombocytopenia Purpura (TTP)
 

CASE REPORT RAPID FIRE WINNERS

Sandeep Patri

Hyperammonemia Postlung Transplantation: An Uncommon But Life-Threatening Complication

Trung Nguyen

Dyspnea During Pregnancy Revealing Multiple Pulmonary Arteriovenous Malformations And A New Diagnosis Of Hereditary Hemorrhagic Telangiectasia

Pedro J. Baez, MD

Adenoid Cystic Adenocarcinoma: A Rare Esophageal Malignancy Misdiagnosed As COPD

Brette Guckian, DO

Management Of Pulmonary Cement Emboli After Kyphoplasty

Brinn Demars, DO

Tumor Emboli In The Pulmonary Artery Secondary To Chondrosarcoma: A Rare Presentation Mimicking Pulmonary Thromboembolism

Aakriti Arora

A Case Of Pulmonary Hypertension As A Possible Extracranial Manifestation Of Moyamoya Disease

Racine Elaine Reinoso

Clot In Transit: The Role Of Point-Of-Care Ultrasound In Early Diagnosis And Improved Outcomes

Qiraat Azeem, MD

A Case Of Autosomal-Dominant Hyper-IgE Syndrome Masquerading As Cystic Fibrosis

Jason R. Ballengee, DO

Third-Trimester Pregnancy Complicated By Non-Small Cell Lung Cancer Initially Presenting With Central Airway Obstruction And Stenosis

Sam Shafer

Caught In The Fray: Neurosarcoidosis Presenting As Chronic Respiratory Failure

Takkin Lo, MD, MPH

China White In Asthmatic Recreational Drug Users: Does It Contribute To Pneumatocele Development?

Sanjeev Shrestha, MD

Successful Treatment Of Microscopic Polyangiitis Using Novel Steroid-Sparing Agent Avacopan

Kristina Menchaca, MD

Cardiac Tamponade Without The Beck Triad: A Complication Of Severe Hypothyroidism

Olivia Millay, BS

Spontaneous Coronary Artery Dissection Of Left Anterior Descending Artery Complicated By Ventricular Septal Rupture

Akruti P. Prabhakar, DO

Delayed Lead Perforation Of The Right Atrium In The Presence Of Persistent Left Superior Vena Cava: A Rare Coincidence

Kevin Hsu, MD

A Modified Valsalva Maneuver For Ventilated And Sedated Patients With Unstable Supraventricular Tachycardia

Nang San Hti Lar Seng

Cardiovascular Manifestations Of Paraaortic Paragangliomas

Rocio Castillo-Larios

Membranous Dehiscence After Tracheal Resection And Reconstruction Healed Spontaneously With Conservative Treatment

Fizza Sajid, DO

A Young Broken Heart, Reversed

Janeen Grant-Sittol, MD

Inhaled Tranexamic Acid Use For Massive Hemoptysis In Vasculitis-Induced Bronchoalveolar Hemorrhage

Raman G. Kutty, Md, PhD

Progressive Lung Infiltrates In Patient With Acquired Immunodeficiency: A Rare Case Of GLILD

Tanwe Shende

Mycobacterium Shimoidei: A Rare Nontuberculous Infection In A U.S. Patient

Sarah M. Upson, MD

Not Your Typical Lactic Acidosis

Prachi Saluja, MD

Late-Onset Immune Thrombotic Thrombocytopenic Purpura (TTP) After Asymptomatic COVID-19 Infection

Steven S. Wu, MD

Type 1 Multiple Endocrine Neoplasia-Associated Tracheobronchial Tumors Managed By Rigid Bronchoscopy-Directed Multimodal Tumor Destruction

Konstantin Golubykh, MD

The Reversal That Helped: Role Of Bedside Echocardiography In Takotsubo Cardiomyopathy

Eric Salomon, MD

Obstructive Tracheobronchial Pulmonary Aspergillosis Managed With Local Bronchoscopic Intervention Alone

Daniel Hoesterey, MD

A Rare Case Of Critical Illness Due To Eczema Herpeticum With Disseminated Herpes Simplex Virus Infection

Awab U. Khan, DO

Severe Colchicine Toxicity In A Suicide Attempt Causing Multiorgan Failure: A Survival Story

Jacob Cebulko

Disseminated Strongyloidiasis In A Patient With Acute Lymphocytic Leukemia

Hasan Baher, MD

Hiding In Plain Sight: Disseminated Pulmonary TB

Navneet Ramesh

Multimodal Management Of Gastric Variceal Bleeding In Hemorrhagic Shock

Jason L. Peng, MD

Improving Compliance With Continuous Anterior Chest Compression In ARDS Caused By COVID-19: A Case Series

Sushan Gupta, MD

Complete Resolution Of Vasoreactive Pulmonary Artery Hypertension In Chronic Hypersensitive Pneumonitis

Mamta S. Chhabria, MD

A Fistulous Issue: Gastropleural Fistula As A Complication Of Gastrectomy

Anita Singh, DO, MBA

Identifying A Novel Surfactant Protein Mutation In A Family With Pulmonary Fibrosis

Rana Prathap Padappayil, MBBS

Delayed Cerebral Venous Sinus Thrombosis (CSVT) After An Invasive Meningioma Resection: An Uncommon Presentation Of A Common Complication

Rubabin Tooba, MD

The Morphing Cavity: An Image Series Of A Patient’s Pulmonary Infarction Over Time

Sally Ziatabar, DO

A Rare Case Of Disseminated Blastomycosis

Sumukh Arun Kumar

Incidental Pulmonary Cavitary Lesions As An Uncommon Presentation Of Lemierre Syndrome

Sophia Emetu

Pet Peeve: Dyspnea From Undiagnosed Pasteurella Multocida Empyema

Chidambaram Ramasamy, MD

A Case Of Diffuse Alveolar-Septal Pulmonary Amyloidosis And Cardiomyopathy

Rachel Swier

Acid-Fast Bacteria In Bronchiectasis: If The Glass Slipper Does Not Fit, Non-TB Mycobacteria, Consider Tsukamurella

Catherine Durant, MD

Idiopathic Multicentric Castleman Disease With Tafro Syndrome And Sjögren Syndrome

Ali Al-Hilli, MD, MSc

Sarcoidosis-Like Reaction During Treatment For Metastatic Breast Cancer With CDK 4/6 Inhibitors: Just An Epiphenomenon Or A Causal Relationship?

Scott Slusarenko, DO

Rapidly Progressive Perimyocarditis In SARS-CoV-2 Infection

Agatha M. Formoso, MD

Two Infants Presenting With Polymicrobial Pneumonia And Hypoxemic Respiratory Failure Associated With Heterozygous Variants In Carmil2 And Itk

Juan Adams-Chahin

The Silence Of “Lam”: A Case Of Tuberous Sclerosis Complex Associated With Lymphangioleiomyomatosis (Lam)

Kathleen Capaccione, MD

Lung Cancer Is Not Always The Answer: Exploring The Differential Diagnosis Of Thoracic Masses

Joann Wongvravit, DO

West Nile-Induced Myasthenia Gravis Crisis: An Unexpected Case Of Respiratory Failure

Ethan Karle, Do

A Rare Cause Of Community-Acquired Bacterial Pneumonia In A Patient With Poorly Controlled Diabetes

Taylor C. Becker, MD

Calcified Cavitary Conundrum: Delayed Diagnosis Of Histoplasmosis

Anneka Hutton, MD

Disseminated Listeriosis: A Deadly Triplicate

Omar Kandah, DO

COVID-19 Cardiac Tamponade With Cardiogenic Shock In A Previously Vaccinated Young Adult: A Case Report

Cihan Caglayan, MD

Partial Anomalous Pulmonary Venous Connection Diagnosed After Central Venous Catheter Placement

Michelle Jones, DO

Delayed Hemophagocytic Lymphohistiocytosis (HLH) Diagnosis In A Patient With Pulmonary Sarcoidosis And Newly Diagnosed T-Cell Lymphoma: A Case Report

Mariah Evarts, MD

A Normotensive Woman With Profound Lactic Acidosis And Stress-Induced Cardiomyopathy

Rachel V. Tan, MD

A Four-Boding Future: Polyviral Infection With SARS-CoV-2, Parainfluenza Virus Type 3, Influenza A, And Adenovirus

Thanh Hoang

Recurrent Syncope From Intermittent Torsades In Loperamide Abuse

Alissa Ali, MD

Ground Glass Opacities In A Patient Receiving Treatment With All-Trans Retinoic Acid And Arsenic Trioxide

Sean M. Masi, DO, MBA

Ferritin-Guided Therapeutic Plasma Exchange (TPE) Administration In COVID-19-Induced Cytokine Storm Syndrome: A Case Series

Anjali Sachdeva

Successful Biopsy Of Aortopulmonary Window Lymph Node With Robotic-Assisted Bronchoscopy

Rehan Saeed, MD

Multiple Sclerosis After COVID-19: A Sign Of Things To Come?

Harshitha Mergey Devender

Invasive Pulmonary Aspergillosis Associated With Nonspecific Interstitial Pneumonia Causing Recurrent Respiratory Failure



Be sure to check out the other award winners on page 20 in the January issue of CHEST Physician: https://tinyurl.com/2bcdcbj3 .

CHEST FOUNDATION GRANT AWARDS

CHEST Foundation Research Grant in Women’s Lung Health Disparities

Laura Sanapo, MD, The Miriam Hospital, Providence, R.I.

This grant is jointly supported by the CHEST Foundation and the Respiratory Health Association.



CHEST Foundation Research Grant in Chronic Obstructive Pulmonary Disease

Benjamin Wu, MD, New York University

This grant is supported by AstraZeneca.



CHEST Foundation Research Grant in Chronic Obstructive Pulmonary Disease

Richard Zou, MD, University of Pittsburgh Medical Center

This grant is supported by the CHEST Foundation.



CHEST Foundation and AASM Foundation Research Grant in Sleep Medicine

Gonzalo Labarca, MD, Universidad San Sebastian, Concepción, Chile

This grant is jointly supported by the CHEST Foundation and AASM Foundation.



CHEST Foundation and American Academy of Dental Sleep Medicine Research Grant in Sleep Apnea

Sherri Katz, MD, FCCP, Children’s Hospital of Eastern Ontario, Ottawa

This grant is supported by the CHEST Foundation and American Academy of Dental Sleep Medicine.



CHEST Foundation Research Grant in Sleep Medicine

Nancy Stewart, DO, University of Kansas Medical Center, Kansas City

This grant is supported by Jazz Pharmaceuticals.



CHEST Foundation Research Grant in Severe Asthma

Gareth Walters, MD, University Hospitals Birmingham (England)

This grant is supported by AstraZeneca.

CHEST Foundation Research Grant in Severe Asthma

Andréanne Côté, MD, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec

This grant is supported by AstraZeneca.



CHEST Foundation and APCCMPD Research Grant in Medical Education

Christopher Leba, MD, MPH, University of California, San Francisco

This grant is jointly supported by the CHEST Foundation and APCCMPD.



CHEST Foundation Research Grant in COVID-19

Clea Barnett, MD, New York University

This grant is supported by the CHEST Foundation.



CHEST Foundation Research Grant in Critical Care

Katherine Walker, MD, Brigham and Women’s Hospital, Harvard Medical School, Boston

This grant is supported by the CHEST Foundation.

CHEST Foundation Research Grant in Venous Thromboembolism

Daniel Lachant, DO, University of Rochester (N.Y.) Medical Center/Strong Memorial Hospital

This grant is supported by the CHEST Foundation.



CHEST Foundation Research Grant in Pulmonary Hypertension

Christina Thornton, MD, PhD, University of Calgary (Alta.)

This grant is supported by the CHEST Foundation.



CHEST Foundation Research Grant in Pulmonary Fibrosis

Christina Eckhardt, MD, Columbia University, New York

This grant is supported by an independent grant from Boehringer Ingelheim Pharmaceuticals and Genentech.



CHEST Foundation Research Grant in Pulmonary Fibrosis

John Kim, MD, University of Virginia, Charlottesville

This grant is supported by an independent grant from Boehringer Ingelheim Pharmaceuticals and Genentech.



John R. Addrizzo, MD, FCCP Research Grant in Sarcoidosis

Kerry Hena, MD, New York University

This grant is in honor of John R. Addrizzo, MD, FCCP and is jointly supported by the Addrizzo family and the CHEST Foundation.



CHEST Foundation Research Grant in Pediatric Lung Health

Adam Shapiro, MD, McGill University Health Centre, Montreal

This grant is supported by the CHEST Foundation.



CHEST Foundation Young Investigator Grant

Sameer Avasarala, MD, Case Western Reserve University, Cleveland

This grant is supported by the CHEST Foundation.



CHEST/ALA/ATS Respiratory Health Equity Research Award

Matthew Triplette, MD, Fred Hutchinson Cancer Research Center, Seattle

The Respiratory Health Equity Research Award is jointly supported by the American Lung Association, the American Thoracic Society, and the CHEST Foundation.



CHEST/ALA/ATS Respiratory Health Equity Research Award

Ayobami Akenroye, MD, MPH, Brigham and Women’s Hospital, Boston

The Respiratory Health Equity Research Award is jointly supported by the American Lung Association, the American Thoracic Society, and the CHEST Foundation.



CHEST Foundation Community Service Grant Honoring D. Robert McCaffree, MD, Master FCCP

Lorriane Odhiambo, PhD, Augusta (Ga.) University

This grant is supported by the CHEST Foundation.



CHEST Foundation Community Service Grant Honoring D. Robert McCaffree, MD, Master FCCP

Katie Stevens, Team Telomere, New York

This grant is supported by the CHEST Foundation.



CHEST Foundation Community Service Grant Honoring D. Robert McCaffree, MD, Master FCCP

Matthew Sharpe, MD, The University of Kansas Medical Center, Kansas City

This grant is supported by the CHEST Foundation.
 

SCIENTIFIC ABSTRACT AWARDS

Alfred Soffer Research Awards

Presented abstracts will be judged by session moderators, and award recipients will be selected for their outstanding original scientific research. Finalists will be evaluated on the basis of their written abstract and the quality of their oral presentation. This award is named in honor of Alfred Soffer, MD, Master FCCP, who was Editor in Chief of the journal CHEST® from 1968 to 1993, and Executive Director of CHEST from 1969 to 1992.



Young Investigator Awards

Investigators who are enrolled in a training or fellowship program or who have completed a fellowship program within 5 years prior to CHEST 2022 are eligible for Young Investigator Awards.

Presenters will be evaluated on the basis of their written abstract and presentation. Recipients will be selected by judges from the Scientific Presentations and Awards Committee for their outstanding original scientific research.

Top Rapid Fire Abstract Award

Awards are granted to two presenters from all the rapid fire sessions at the CHEST Annual Meeting for outstanding original scientific research and presentation



Top Case Report Award

Awards are granted to one presenter in each oral case report session at the CHEST Annual Meeting for outstanding original scientific research and presentation



Top Rapid Fire Case Report Award

Awards are granted to one presenter in each rapid fire oral case report session at the CHEST Annual Meeting for outstanding original scientific research and presentation

 

ALFRED SOFFER RESEARCH AWARD WINNERS

Palak Rath, MD

A Sense Of Urgency: Boarding Of Critical Care Medicine Patients In The ED

Syed Nazeer Mahmood, MD

Quantifying The Risk For Overtreatment And Undertreatment Of Severe Community Onset Pneumonia
 

YOUNG INVESTIGATOR AWARD WINNERS

Anusha Devarajan, MD, MBBS

Pneumomediastinum And Pneumothorax In COVID-19 Pneumonia: A Matched Case-Control Study

Marjan Islam, MD

Thoracic Ultrasound In COVID-19: Use Of Lung And Diaphragm Ultrasound In Evaluating Dyspnea In Survivors Of Critical Illness From COVID-19 Pneumonia In A Post-ICU Clinic

Aaron St Laurent, MD

Duchenne Muscular Dystrophy Respiratory Profiles From Real-World Registry Data: A Retrospective Longitudinal Study
 

ABSTRACT RAPID FIRE WINNERS

Andrew J.O. Davis, MD

Early Gas Exchange Parameters Not Associated With Survival In COVID-19-Associated ARDS Patients Requiring Prolonged Venovenous Extracorporeal Membrane Oxygenation

Benjamin Emmanuel

Clinical Outcomes In Patients With Severe Asthma Who Had Or Had Not Initiated Biologic Therapy: Results From The CLEAR Study
 

CASE REPORT SESSION WINNERS

Sathya Alekhya Bukkuri

Smarca4-Deficient Undifferentiated Tumor: A Rare Thoracic Malignancy

Zachary A. Banbury, MD

Fungal Aortitis In A Patient For Whom Blood Transfusion Is Not An Option: A Rare But Potentially Fatal Complication Of Aortic Valve Replacement

Harinivaas Shanmugavel Geetha, MD

Respiratory Distress After Potentially Fatal Aspirin Overdose: When To Intubate?

Lisa Hayes

Systemic Epstein-Barr Virus-Related T-Cell Lymphoproliferative Disorder: A Rare Cause Of Dyspnea And Pulmonary Infiltrates In An Immunocompetent Adult

Mohammed Alsaggaf, MBBS

Calcium Oxalate Deposition In Pulmonary Aspergillosis

Cheyenne Snavely

Traffic Jam In The Vasculature: A Case Of Pulmonary Leukostasis

Clarissa Smith, MD

Talcoma In Lung Cancer Screening: A Rare Benign Cause Of PET Scan Avidity

Nitin Gupta, MD

The Clue Is In The Blood Gas: A Rare Manifestation Of Lactic Acidosis

Moses Hayrabedian, MD

A Century-Old Infection Mimicking Malignancy: A Case Of Diffuse Histoplasmosis

Gabriel R. Schroeder, MD

A Case Of Wind-Instrument Associated Hypersensitivity Pneumonitis

Fizza Sajid, DO

Leaping From Lush Tropical Environments To The L-Train: A Case Of Severe Leptospirosis In New York City

Krista R. Dollar, MD

Looking Past The Ground Glass: It Was Only Skin Deep

Konstantin Golubykh, MD

Point-Of-Care Ultrasound In The Timely Diagnosis Of Colonic Necrosis

Arsal Tharwani

Abdominal Compression In End-Stage Fibrotic Interstitial Lung Disease (ILD) Improves Respiratory Compliance

Ryan Kozloski

When Asthma Isn’t: Multispecialty Approach To Fibrosing Mediastinitis

Zach S. Jarrett, DO

Vanishing Cancer: A Case Of Smoking-Related Organizing Pneumonia

Stephen Simeone

Intravascular Papillary Endothelial Hyperplasia Presenting As Thrombus In Transit With Acute Pulmonary Embolism

David Gruen, MD

Tackling Posterior Reversible Encephalopathy Syndrome (PRES): A Rare Case Of Subtherapeutic Tacrolimus Causing PRES In Steroid-Resistant Nephropathy

Nicholas Kunce, MD

An Unusual Case Of Subacute Bacterial Endocarditis Presenting With Catastrophic Subarachnoid Hemorrhage

Phillip J. Gary, MD

Sarcoid-Like Reaction After Treatment With Pembrolizumab

Shreya Podder, MD

Endobronchial Valves For Treatment Of Persistent Air Leak After Secondary Spontaneous Pneumothorax In Patients With Cystic Fibrosis

Alina Aw Wasim, MD, MBBS

Chest-Wall Castleman Disease Mimicking Thymoma Drop Metastasis

Ndausung Udongwo

The ‘Rat Bite Sign” On Cardiac MRI: Left Dominant Arrhythmogenic Cardiomyopathy As An Atypical Etiology Of Sudden Cardiac Arrest

Grant Senyei, MD

Management Of Ventriculopleural Shunt-Associated Pleural Effusion

Garima Singh, MD

COVID-19-Associated Thrombotic Thrombocytopenia Purpura (TTP)
 

CASE REPORT RAPID FIRE WINNERS

Sandeep Patri

Hyperammonemia Postlung Transplantation: An Uncommon But Life-Threatening Complication

Trung Nguyen

Dyspnea During Pregnancy Revealing Multiple Pulmonary Arteriovenous Malformations And A New Diagnosis Of Hereditary Hemorrhagic Telangiectasia

Pedro J. Baez, MD

Adenoid Cystic Adenocarcinoma: A Rare Esophageal Malignancy Misdiagnosed As COPD

Brette Guckian, DO

Management Of Pulmonary Cement Emboli After Kyphoplasty

Brinn Demars, DO

Tumor Emboli In The Pulmonary Artery Secondary To Chondrosarcoma: A Rare Presentation Mimicking Pulmonary Thromboembolism

Aakriti Arora

A Case Of Pulmonary Hypertension As A Possible Extracranial Manifestation Of Moyamoya Disease

Racine Elaine Reinoso

Clot In Transit: The Role Of Point-Of-Care Ultrasound In Early Diagnosis And Improved Outcomes

Qiraat Azeem, MD

A Case Of Autosomal-Dominant Hyper-IgE Syndrome Masquerading As Cystic Fibrosis

Jason R. Ballengee, DO

Third-Trimester Pregnancy Complicated By Non-Small Cell Lung Cancer Initially Presenting With Central Airway Obstruction And Stenosis

Sam Shafer

Caught In The Fray: Neurosarcoidosis Presenting As Chronic Respiratory Failure

Takkin Lo, MD, MPH

China White In Asthmatic Recreational Drug Users: Does It Contribute To Pneumatocele Development?

Sanjeev Shrestha, MD

Successful Treatment Of Microscopic Polyangiitis Using Novel Steroid-Sparing Agent Avacopan

Kristina Menchaca, MD

Cardiac Tamponade Without The Beck Triad: A Complication Of Severe Hypothyroidism

Olivia Millay, BS

Spontaneous Coronary Artery Dissection Of Left Anterior Descending Artery Complicated By Ventricular Septal Rupture

Akruti P. Prabhakar, DO

Delayed Lead Perforation Of The Right Atrium In The Presence Of Persistent Left Superior Vena Cava: A Rare Coincidence

Kevin Hsu, MD

A Modified Valsalva Maneuver For Ventilated And Sedated Patients With Unstable Supraventricular Tachycardia

Nang San Hti Lar Seng

Cardiovascular Manifestations Of Paraaortic Paragangliomas

Rocio Castillo-Larios

Membranous Dehiscence After Tracheal Resection And Reconstruction Healed Spontaneously With Conservative Treatment

Fizza Sajid, DO

A Young Broken Heart, Reversed

Janeen Grant-Sittol, MD

Inhaled Tranexamic Acid Use For Massive Hemoptysis In Vasculitis-Induced Bronchoalveolar Hemorrhage

Raman G. Kutty, Md, PhD

Progressive Lung Infiltrates In Patient With Acquired Immunodeficiency: A Rare Case Of GLILD

Tanwe Shende

Mycobacterium Shimoidei: A Rare Nontuberculous Infection In A U.S. Patient

Sarah M. Upson, MD

Not Your Typical Lactic Acidosis

Prachi Saluja, MD

Late-Onset Immune Thrombotic Thrombocytopenic Purpura (TTP) After Asymptomatic COVID-19 Infection

Steven S. Wu, MD

Type 1 Multiple Endocrine Neoplasia-Associated Tracheobronchial Tumors Managed By Rigid Bronchoscopy-Directed Multimodal Tumor Destruction

Konstantin Golubykh, MD

The Reversal That Helped: Role Of Bedside Echocardiography In Takotsubo Cardiomyopathy

Eric Salomon, MD

Obstructive Tracheobronchial Pulmonary Aspergillosis Managed With Local Bronchoscopic Intervention Alone

Daniel Hoesterey, MD

A Rare Case Of Critical Illness Due To Eczema Herpeticum With Disseminated Herpes Simplex Virus Infection

Awab U. Khan, DO

Severe Colchicine Toxicity In A Suicide Attempt Causing Multiorgan Failure: A Survival Story

Jacob Cebulko

Disseminated Strongyloidiasis In A Patient With Acute Lymphocytic Leukemia

Hasan Baher, MD

Hiding In Plain Sight: Disseminated Pulmonary TB

Navneet Ramesh

Multimodal Management Of Gastric Variceal Bleeding In Hemorrhagic Shock

Jason L. Peng, MD

Improving Compliance With Continuous Anterior Chest Compression In ARDS Caused By COVID-19: A Case Series

Sushan Gupta, MD

Complete Resolution Of Vasoreactive Pulmonary Artery Hypertension In Chronic Hypersensitive Pneumonitis

Mamta S. Chhabria, MD

A Fistulous Issue: Gastropleural Fistula As A Complication Of Gastrectomy

Anita Singh, DO, MBA

Identifying A Novel Surfactant Protein Mutation In A Family With Pulmonary Fibrosis

Rana Prathap Padappayil, MBBS

Delayed Cerebral Venous Sinus Thrombosis (CSVT) After An Invasive Meningioma Resection: An Uncommon Presentation Of A Common Complication

Rubabin Tooba, MD

The Morphing Cavity: An Image Series Of A Patient’s Pulmonary Infarction Over Time

Sally Ziatabar, DO

A Rare Case Of Disseminated Blastomycosis

Sumukh Arun Kumar

Incidental Pulmonary Cavitary Lesions As An Uncommon Presentation Of Lemierre Syndrome

Sophia Emetu

Pet Peeve: Dyspnea From Undiagnosed Pasteurella Multocida Empyema

Chidambaram Ramasamy, MD

A Case Of Diffuse Alveolar-Septal Pulmonary Amyloidosis And Cardiomyopathy

Rachel Swier

Acid-Fast Bacteria In Bronchiectasis: If The Glass Slipper Does Not Fit, Non-TB Mycobacteria, Consider Tsukamurella

Catherine Durant, MD

Idiopathic Multicentric Castleman Disease With Tafro Syndrome And Sjögren Syndrome

Ali Al-Hilli, MD, MSc

Sarcoidosis-Like Reaction During Treatment For Metastatic Breast Cancer With CDK 4/6 Inhibitors: Just An Epiphenomenon Or A Causal Relationship?

Scott Slusarenko, DO

Rapidly Progressive Perimyocarditis In SARS-CoV-2 Infection

Agatha M. Formoso, MD

Two Infants Presenting With Polymicrobial Pneumonia And Hypoxemic Respiratory Failure Associated With Heterozygous Variants In Carmil2 And Itk

Juan Adams-Chahin

The Silence Of “Lam”: A Case Of Tuberous Sclerosis Complex Associated With Lymphangioleiomyomatosis (Lam)

Kathleen Capaccione, MD

Lung Cancer Is Not Always The Answer: Exploring The Differential Diagnosis Of Thoracic Masses

Joann Wongvravit, DO

West Nile-Induced Myasthenia Gravis Crisis: An Unexpected Case Of Respiratory Failure

Ethan Karle, Do

A Rare Cause Of Community-Acquired Bacterial Pneumonia In A Patient With Poorly Controlled Diabetes

Taylor C. Becker, MD

Calcified Cavitary Conundrum: Delayed Diagnosis Of Histoplasmosis

Anneka Hutton, MD

Disseminated Listeriosis: A Deadly Triplicate

Omar Kandah, DO

COVID-19 Cardiac Tamponade With Cardiogenic Shock In A Previously Vaccinated Young Adult: A Case Report

Cihan Caglayan, MD

Partial Anomalous Pulmonary Venous Connection Diagnosed After Central Venous Catheter Placement

Michelle Jones, DO

Delayed Hemophagocytic Lymphohistiocytosis (HLH) Diagnosis In A Patient With Pulmonary Sarcoidosis And Newly Diagnosed T-Cell Lymphoma: A Case Report

Mariah Evarts, MD

A Normotensive Woman With Profound Lactic Acidosis And Stress-Induced Cardiomyopathy

Rachel V. Tan, MD

A Four-Boding Future: Polyviral Infection With SARS-CoV-2, Parainfluenza Virus Type 3, Influenza A, And Adenovirus

Thanh Hoang

Recurrent Syncope From Intermittent Torsades In Loperamide Abuse

Alissa Ali, MD

Ground Glass Opacities In A Patient Receiving Treatment With All-Trans Retinoic Acid And Arsenic Trioxide

Sean M. Masi, DO, MBA

Ferritin-Guided Therapeutic Plasma Exchange (TPE) Administration In COVID-19-Induced Cytokine Storm Syndrome: A Case Series

Anjali Sachdeva

Successful Biopsy Of Aortopulmonary Window Lymph Node With Robotic-Assisted Bronchoscopy

Rehan Saeed, MD

Multiple Sclerosis After COVID-19: A Sign Of Things To Come?

Harshitha Mergey Devender

Invasive Pulmonary Aspergillosis Associated With Nonspecific Interstitial Pneumonia Causing Recurrent Respiratory Failure



Be sure to check out the other award winners on page 20 in the January issue of CHEST Physician: https://tinyurl.com/2bcdcbj3 .

CHEST FOUNDATION GRANT AWARDS

CHEST Foundation Research Grant in Women’s Lung Health Disparities

Laura Sanapo, MD, The Miriam Hospital, Providence, R.I.

This grant is jointly supported by the CHEST Foundation and the Respiratory Health Association.



CHEST Foundation Research Grant in Chronic Obstructive Pulmonary Disease

Benjamin Wu, MD, New York University

This grant is supported by AstraZeneca.



CHEST Foundation Research Grant in Chronic Obstructive Pulmonary Disease

Richard Zou, MD, University of Pittsburgh Medical Center

This grant is supported by the CHEST Foundation.



CHEST Foundation and AASM Foundation Research Grant in Sleep Medicine

Gonzalo Labarca, MD, Universidad San Sebastian, Concepción, Chile

This grant is jointly supported by the CHEST Foundation and AASM Foundation.



CHEST Foundation and American Academy of Dental Sleep Medicine Research Grant in Sleep Apnea

Sherri Katz, MD, FCCP, Children’s Hospital of Eastern Ontario, Ottawa

This grant is supported by the CHEST Foundation and American Academy of Dental Sleep Medicine.



CHEST Foundation Research Grant in Sleep Medicine

Nancy Stewart, DO, University of Kansas Medical Center, Kansas City

This grant is supported by Jazz Pharmaceuticals.



CHEST Foundation Research Grant in Severe Asthma

Gareth Walters, MD, University Hospitals Birmingham (England)

This grant is supported by AstraZeneca.

CHEST Foundation Research Grant in Severe Asthma

Andréanne Côté, MD, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec

This grant is supported by AstraZeneca.



CHEST Foundation and APCCMPD Research Grant in Medical Education

Christopher Leba, MD, MPH, University of California, San Francisco

This grant is jointly supported by the CHEST Foundation and APCCMPD.



CHEST Foundation Research Grant in COVID-19

Clea Barnett, MD, New York University

This grant is supported by the CHEST Foundation.



CHEST Foundation Research Grant in Critical Care

Katherine Walker, MD, Brigham and Women’s Hospital, Harvard Medical School, Boston

This grant is supported by the CHEST Foundation.

CHEST Foundation Research Grant in Venous Thromboembolism

Daniel Lachant, DO, University of Rochester (N.Y.) Medical Center/Strong Memorial Hospital

This grant is supported by the CHEST Foundation.



CHEST Foundation Research Grant in Pulmonary Hypertension

Christina Thornton, MD, PhD, University of Calgary (Alta.)

This grant is supported by the CHEST Foundation.



CHEST Foundation Research Grant in Pulmonary Fibrosis

Christina Eckhardt, MD, Columbia University, New York

This grant is supported by an independent grant from Boehringer Ingelheim Pharmaceuticals and Genentech.



CHEST Foundation Research Grant in Pulmonary Fibrosis

John Kim, MD, University of Virginia, Charlottesville

This grant is supported by an independent grant from Boehringer Ingelheim Pharmaceuticals and Genentech.



John R. Addrizzo, MD, FCCP Research Grant in Sarcoidosis

Kerry Hena, MD, New York University

This grant is in honor of John R. Addrizzo, MD, FCCP and is jointly supported by the Addrizzo family and the CHEST Foundation.



CHEST Foundation Research Grant in Pediatric Lung Health

Adam Shapiro, MD, McGill University Health Centre, Montreal

This grant is supported by the CHEST Foundation.



CHEST Foundation Young Investigator Grant

Sameer Avasarala, MD, Case Western Reserve University, Cleveland

This grant is supported by the CHEST Foundation.



CHEST/ALA/ATS Respiratory Health Equity Research Award

Matthew Triplette, MD, Fred Hutchinson Cancer Research Center, Seattle

The Respiratory Health Equity Research Award is jointly supported by the American Lung Association, the American Thoracic Society, and the CHEST Foundation.



CHEST/ALA/ATS Respiratory Health Equity Research Award

Ayobami Akenroye, MD, MPH, Brigham and Women’s Hospital, Boston

The Respiratory Health Equity Research Award is jointly supported by the American Lung Association, the American Thoracic Society, and the CHEST Foundation.



CHEST Foundation Community Service Grant Honoring D. Robert McCaffree, MD, Master FCCP

Lorriane Odhiambo, PhD, Augusta (Ga.) University

This grant is supported by the CHEST Foundation.



CHEST Foundation Community Service Grant Honoring D. Robert McCaffree, MD, Master FCCP

Katie Stevens, Team Telomere, New York

This grant is supported by the CHEST Foundation.



CHEST Foundation Community Service Grant Honoring D. Robert McCaffree, MD, Master FCCP

Matthew Sharpe, MD, The University of Kansas Medical Center, Kansas City

This grant is supported by the CHEST Foundation.
 

SCIENTIFIC ABSTRACT AWARDS

Alfred Soffer Research Awards

Presented abstracts will be judged by session moderators, and award recipients will be selected for their outstanding original scientific research. Finalists will be evaluated on the basis of their written abstract and the quality of their oral presentation. This award is named in honor of Alfred Soffer, MD, Master FCCP, who was Editor in Chief of the journal CHEST® from 1968 to 1993, and Executive Director of CHEST from 1969 to 1992.



Young Investigator Awards

Investigators who are enrolled in a training or fellowship program or who have completed a fellowship program within 5 years prior to CHEST 2022 are eligible for Young Investigator Awards.

Presenters will be evaluated on the basis of their written abstract and presentation. Recipients will be selected by judges from the Scientific Presentations and Awards Committee for their outstanding original scientific research.

Top Rapid Fire Abstract Award

Awards are granted to two presenters from all the rapid fire sessions at the CHEST Annual Meeting for outstanding original scientific research and presentation



Top Case Report Award

Awards are granted to one presenter in each oral case report session at the CHEST Annual Meeting for outstanding original scientific research and presentation



Top Rapid Fire Case Report Award

Awards are granted to one presenter in each rapid fire oral case report session at the CHEST Annual Meeting for outstanding original scientific research and presentation

 

ALFRED SOFFER RESEARCH AWARD WINNERS

Palak Rath, MD

A Sense Of Urgency: Boarding Of Critical Care Medicine Patients In The ED

Syed Nazeer Mahmood, MD

Quantifying The Risk For Overtreatment And Undertreatment Of Severe Community Onset Pneumonia
 

YOUNG INVESTIGATOR AWARD WINNERS

Anusha Devarajan, MD, MBBS

Pneumomediastinum And Pneumothorax In COVID-19 Pneumonia: A Matched Case-Control Study

Marjan Islam, MD

Thoracic Ultrasound In COVID-19: Use Of Lung And Diaphragm Ultrasound In Evaluating Dyspnea In Survivors Of Critical Illness From COVID-19 Pneumonia In A Post-ICU Clinic

Aaron St Laurent, MD

Duchenne Muscular Dystrophy Respiratory Profiles From Real-World Registry Data: A Retrospective Longitudinal Study
 

ABSTRACT RAPID FIRE WINNERS

Andrew J.O. Davis, MD

Early Gas Exchange Parameters Not Associated With Survival In COVID-19-Associated ARDS Patients Requiring Prolonged Venovenous Extracorporeal Membrane Oxygenation

Benjamin Emmanuel

Clinical Outcomes In Patients With Severe Asthma Who Had Or Had Not Initiated Biologic Therapy: Results From The CLEAR Study
 

CASE REPORT SESSION WINNERS

Sathya Alekhya Bukkuri

Smarca4-Deficient Undifferentiated Tumor: A Rare Thoracic Malignancy

Zachary A. Banbury, MD

Fungal Aortitis In A Patient For Whom Blood Transfusion Is Not An Option: A Rare But Potentially Fatal Complication Of Aortic Valve Replacement

Harinivaas Shanmugavel Geetha, MD

Respiratory Distress After Potentially Fatal Aspirin Overdose: When To Intubate?

Lisa Hayes

Systemic Epstein-Barr Virus-Related T-Cell Lymphoproliferative Disorder: A Rare Cause Of Dyspnea And Pulmonary Infiltrates In An Immunocompetent Adult

Mohammed Alsaggaf, MBBS

Calcium Oxalate Deposition In Pulmonary Aspergillosis

Cheyenne Snavely

Traffic Jam In The Vasculature: A Case Of Pulmonary Leukostasis

Clarissa Smith, MD

Talcoma In Lung Cancer Screening: A Rare Benign Cause Of PET Scan Avidity

Nitin Gupta, MD

The Clue Is In The Blood Gas: A Rare Manifestation Of Lactic Acidosis

Moses Hayrabedian, MD

A Century-Old Infection Mimicking Malignancy: A Case Of Diffuse Histoplasmosis

Gabriel R. Schroeder, MD

A Case Of Wind-Instrument Associated Hypersensitivity Pneumonitis

Fizza Sajid, DO

Leaping From Lush Tropical Environments To The L-Train: A Case Of Severe Leptospirosis In New York City

Krista R. Dollar, MD

Looking Past The Ground Glass: It Was Only Skin Deep

Konstantin Golubykh, MD

Point-Of-Care Ultrasound In The Timely Diagnosis Of Colonic Necrosis

Arsal Tharwani

Abdominal Compression In End-Stage Fibrotic Interstitial Lung Disease (ILD) Improves Respiratory Compliance

Ryan Kozloski

When Asthma Isn’t: Multispecialty Approach To Fibrosing Mediastinitis

Zach S. Jarrett, DO

Vanishing Cancer: A Case Of Smoking-Related Organizing Pneumonia

Stephen Simeone

Intravascular Papillary Endothelial Hyperplasia Presenting As Thrombus In Transit With Acute Pulmonary Embolism

David Gruen, MD

Tackling Posterior Reversible Encephalopathy Syndrome (PRES): A Rare Case Of Subtherapeutic Tacrolimus Causing PRES In Steroid-Resistant Nephropathy

Nicholas Kunce, MD

An Unusual Case Of Subacute Bacterial Endocarditis Presenting With Catastrophic Subarachnoid Hemorrhage

Phillip J. Gary, MD

Sarcoid-Like Reaction After Treatment With Pembrolizumab

Shreya Podder, MD

Endobronchial Valves For Treatment Of Persistent Air Leak After Secondary Spontaneous Pneumothorax In Patients With Cystic Fibrosis

Alina Aw Wasim, MD, MBBS

Chest-Wall Castleman Disease Mimicking Thymoma Drop Metastasis

Ndausung Udongwo

The ‘Rat Bite Sign” On Cardiac MRI: Left Dominant Arrhythmogenic Cardiomyopathy As An Atypical Etiology Of Sudden Cardiac Arrest

Grant Senyei, MD

Management Of Ventriculopleural Shunt-Associated Pleural Effusion

Garima Singh, MD

COVID-19-Associated Thrombotic Thrombocytopenia Purpura (TTP)
 

CASE REPORT RAPID FIRE WINNERS

Sandeep Patri

Hyperammonemia Postlung Transplantation: An Uncommon But Life-Threatening Complication

Trung Nguyen

Dyspnea During Pregnancy Revealing Multiple Pulmonary Arteriovenous Malformations And A New Diagnosis Of Hereditary Hemorrhagic Telangiectasia

Pedro J. Baez, MD

Adenoid Cystic Adenocarcinoma: A Rare Esophageal Malignancy Misdiagnosed As COPD

Brette Guckian, DO

Management Of Pulmonary Cement Emboli After Kyphoplasty

Brinn Demars, DO

Tumor Emboli In The Pulmonary Artery Secondary To Chondrosarcoma: A Rare Presentation Mimicking Pulmonary Thromboembolism

Aakriti Arora

A Case Of Pulmonary Hypertension As A Possible Extracranial Manifestation Of Moyamoya Disease

Racine Elaine Reinoso

Clot In Transit: The Role Of Point-Of-Care Ultrasound In Early Diagnosis And Improved Outcomes

Qiraat Azeem, MD

A Case Of Autosomal-Dominant Hyper-IgE Syndrome Masquerading As Cystic Fibrosis

Jason R. Ballengee, DO

Third-Trimester Pregnancy Complicated By Non-Small Cell Lung Cancer Initially Presenting With Central Airway Obstruction And Stenosis

Sam Shafer

Caught In The Fray: Neurosarcoidosis Presenting As Chronic Respiratory Failure

Takkin Lo, MD, MPH

China White In Asthmatic Recreational Drug Users: Does It Contribute To Pneumatocele Development?

Sanjeev Shrestha, MD

Successful Treatment Of Microscopic Polyangiitis Using Novel Steroid-Sparing Agent Avacopan

Kristina Menchaca, MD

Cardiac Tamponade Without The Beck Triad: A Complication Of Severe Hypothyroidism

Olivia Millay, BS

Spontaneous Coronary Artery Dissection Of Left Anterior Descending Artery Complicated By Ventricular Septal Rupture

Akruti P. Prabhakar, DO

Delayed Lead Perforation Of The Right Atrium In The Presence Of Persistent Left Superior Vena Cava: A Rare Coincidence

Kevin Hsu, MD

A Modified Valsalva Maneuver For Ventilated And Sedated Patients With Unstable Supraventricular Tachycardia

Nang San Hti Lar Seng

Cardiovascular Manifestations Of Paraaortic Paragangliomas

Rocio Castillo-Larios

Membranous Dehiscence After Tracheal Resection And Reconstruction Healed Spontaneously With Conservative Treatment

Fizza Sajid, DO

A Young Broken Heart, Reversed

Janeen Grant-Sittol, MD

Inhaled Tranexamic Acid Use For Massive Hemoptysis In Vasculitis-Induced Bronchoalveolar Hemorrhage

Raman G. Kutty, Md, PhD

Progressive Lung Infiltrates In Patient With Acquired Immunodeficiency: A Rare Case Of GLILD

Tanwe Shende

Mycobacterium Shimoidei: A Rare Nontuberculous Infection In A U.S. Patient

Sarah M. Upson, MD

Not Your Typical Lactic Acidosis

Prachi Saluja, MD

Late-Onset Immune Thrombotic Thrombocytopenic Purpura (TTP) After Asymptomatic COVID-19 Infection

Steven S. Wu, MD

Type 1 Multiple Endocrine Neoplasia-Associated Tracheobronchial Tumors Managed By Rigid Bronchoscopy-Directed Multimodal Tumor Destruction

Konstantin Golubykh, MD

The Reversal That Helped: Role Of Bedside Echocardiography In Takotsubo Cardiomyopathy

Eric Salomon, MD

Obstructive Tracheobronchial Pulmonary Aspergillosis Managed With Local Bronchoscopic Intervention Alone

Daniel Hoesterey, MD

A Rare Case Of Critical Illness Due To Eczema Herpeticum With Disseminated Herpes Simplex Virus Infection

Awab U. Khan, DO

Severe Colchicine Toxicity In A Suicide Attempt Causing Multiorgan Failure: A Survival Story

Jacob Cebulko

Disseminated Strongyloidiasis In A Patient With Acute Lymphocytic Leukemia

Hasan Baher, MD

Hiding In Plain Sight: Disseminated Pulmonary TB

Navneet Ramesh

Multimodal Management Of Gastric Variceal Bleeding In Hemorrhagic Shock

Jason L. Peng, MD

Improving Compliance With Continuous Anterior Chest Compression In ARDS Caused By COVID-19: A Case Series

Sushan Gupta, MD

Complete Resolution Of Vasoreactive Pulmonary Artery Hypertension In Chronic Hypersensitive Pneumonitis

Mamta S. Chhabria, MD

A Fistulous Issue: Gastropleural Fistula As A Complication Of Gastrectomy

Anita Singh, DO, MBA

Identifying A Novel Surfactant Protein Mutation In A Family With Pulmonary Fibrosis

Rana Prathap Padappayil, MBBS

Delayed Cerebral Venous Sinus Thrombosis (CSVT) After An Invasive Meningioma Resection: An Uncommon Presentation Of A Common Complication

Rubabin Tooba, MD

The Morphing Cavity: An Image Series Of A Patient’s Pulmonary Infarction Over Time

Sally Ziatabar, DO

A Rare Case Of Disseminated Blastomycosis

Sumukh Arun Kumar

Incidental Pulmonary Cavitary Lesions As An Uncommon Presentation Of Lemierre Syndrome

Sophia Emetu

Pet Peeve: Dyspnea From Undiagnosed Pasteurella Multocida Empyema

Chidambaram Ramasamy, MD

A Case Of Diffuse Alveolar-Septal Pulmonary Amyloidosis And Cardiomyopathy

Rachel Swier

Acid-Fast Bacteria In Bronchiectasis: If The Glass Slipper Does Not Fit, Non-TB Mycobacteria, Consider Tsukamurella

Catherine Durant, MD

Idiopathic Multicentric Castleman Disease With Tafro Syndrome And Sjögren Syndrome

Ali Al-Hilli, MD, MSc

Sarcoidosis-Like Reaction During Treatment For Metastatic Breast Cancer With CDK 4/6 Inhibitors: Just An Epiphenomenon Or A Causal Relationship?

Scott Slusarenko, DO

Rapidly Progressive Perimyocarditis In SARS-CoV-2 Infection

Agatha M. Formoso, MD

Two Infants Presenting With Polymicrobial Pneumonia And Hypoxemic Respiratory Failure Associated With Heterozygous Variants In Carmil2 And Itk

Juan Adams-Chahin

The Silence Of “Lam”: A Case Of Tuberous Sclerosis Complex Associated With Lymphangioleiomyomatosis (Lam)

Kathleen Capaccione, MD

Lung Cancer Is Not Always The Answer: Exploring The Differential Diagnosis Of Thoracic Masses

Joann Wongvravit, DO

West Nile-Induced Myasthenia Gravis Crisis: An Unexpected Case Of Respiratory Failure

Ethan Karle, Do

A Rare Cause Of Community-Acquired Bacterial Pneumonia In A Patient With Poorly Controlled Diabetes

Taylor C. Becker, MD

Calcified Cavitary Conundrum: Delayed Diagnosis Of Histoplasmosis

Anneka Hutton, MD

Disseminated Listeriosis: A Deadly Triplicate

Omar Kandah, DO

COVID-19 Cardiac Tamponade With Cardiogenic Shock In A Previously Vaccinated Young Adult: A Case Report

Cihan Caglayan, MD

Partial Anomalous Pulmonary Venous Connection Diagnosed After Central Venous Catheter Placement

Michelle Jones, DO

Delayed Hemophagocytic Lymphohistiocytosis (HLH) Diagnosis In A Patient With Pulmonary Sarcoidosis And Newly Diagnosed T-Cell Lymphoma: A Case Report

Mariah Evarts, MD

A Normotensive Woman With Profound Lactic Acidosis And Stress-Induced Cardiomyopathy

Rachel V. Tan, MD

A Four-Boding Future: Polyviral Infection With SARS-CoV-2, Parainfluenza Virus Type 3, Influenza A, And Adenovirus

Thanh Hoang

Recurrent Syncope From Intermittent Torsades In Loperamide Abuse

Alissa Ali, MD

Ground Glass Opacities In A Patient Receiving Treatment With All-Trans Retinoic Acid And Arsenic Trioxide

Sean M. Masi, DO, MBA

Ferritin-Guided Therapeutic Plasma Exchange (TPE) Administration In COVID-19-Induced Cytokine Storm Syndrome: A Case Series

Anjali Sachdeva

Successful Biopsy Of Aortopulmonary Window Lymph Node With Robotic-Assisted Bronchoscopy

Rehan Saeed, MD

Multiple Sclerosis After COVID-19: A Sign Of Things To Come?

Harshitha Mergey Devender

Invasive Pulmonary Aspergillosis Associated With Nonspecific Interstitial Pneumonia Causing Recurrent Respiratory Failure



Be sure to check out the other award winners on page 20 in the January issue of CHEST Physician: https://tinyurl.com/2bcdcbj3 .

Here we are, 1 month into the new year, and it already feels like my time as President of the American College of Chest Physicians will pass too quickly. One of my goals is to share some thoughts on issues important to our profession by contributing quarterly to CHEST Physician. CHEST has always been like an extended family to me, and I look forward to having this regular touchpoint with all of you.

For my first written contribution, I want to focus on the future of medicine through medical education and involvement in professional associations because I am, at heart, a medical educator.

During my address at the CHEST Annual Meeting 2022, I spoke on how CHEST provided me with networking, mentoring, and volunteer opportunities that were critical in advancing my career. Those same opportunities should be extended to everyone in pulmonary, critical care, and sleep medicine – whether a current member or prospective member.
 

Lighting a fire

Attending my first CHEST Annual Meeting was possible due to my nomination for a leadership development course. The connections I made during the meeting really lit a fire within me. We need to engage with early career clinicians and provide them the same exposure and encouragement that I received.

To instill this fire in the next generation, I encourage each of our established members, years (or decades) into their careers, to pass along their expertise to someone who is just starting out, whether it be a trainee or a junior faculty member. If this applies to you: encourage a new attending who has never been to a CHEST event to attend with you; invite a fellow or resident to submit an abstract or case report to the journal CHEST® with your oversight; or simply volunteer to speak at your medical school or residency program about why you chose PCCM and the career it has given you.

Think back to when you were embarking on your journey toward where you are now – what would it have meant to be able to get career advice or even just a friendly conversation started with someone at your current level?
 

CHEST offerings and accreditations

Beyond bringing someone to a CHEST Annual Meeting – which you should definitely do – work with your learners at medical schools and residency programs to expose them to CHEST much earlier in their careers. The Trainings and Transitions Committee is an excellent resource to guide newer clinicians and can provide a vital source of encouragement and support. If your institution doesn’t have a simulation learning center or if it has limited offerings, the hands-on learning opportunities offered at CHEST headquarters may be a fit. Accredited by the Society for Simulation in Healthcare (SSH) and the Accreditation Council for Continuing Medical Education (ACCME), CHEST currently offers 24 courses with four new courses planned for 2023 in a wide variety of areas, including courses on ultrasound and bronchoscopy.

There are so many ways to introduce early career clinicians to CHEST, and it can begin with one personal outreach. If you are working on a project for CHEST right now, consider inviting an early career clinician to join you on it – this may be the opportunity that will change their career. It did for me.

As medical professionals, each of us plays an important role in the future of medicine, and the CHEST organization can bring us together to strengthen our impact.

If you are interested in brainstorming ideas for how to engage your medical students, residents, or fellows, please feel free to contact me or anyone at CHEST to help create a plan.

I look forward to the next time we connect.

Doreen J. Addrizzo-Harris, MD, FCCP

CHEST President

Here we are, 1 month into the new year, and it already feels like my time as President of the American College of Chest Physicians will pass too quickly. One of my goals is to share some thoughts on issues important to our profession by contributing quarterly to CHEST Physician. CHEST has always been like an extended family to me, and I look forward to having this regular touchpoint with all of you.

For my first written contribution, I want to focus on the future of medicine through medical education and involvement in professional associations because I am, at heart, a medical educator.

During my address at the CHEST Annual Meeting 2022, I spoke on how CHEST provided me with networking, mentoring, and volunteer opportunities that were critical in advancing my career. Those same opportunities should be extended to everyone in pulmonary, critical care, and sleep medicine – whether a current member or prospective member.
 

Lighting a fire

Attending my first CHEST Annual Meeting was possible due to my nomination for a leadership development course. The connections I made during the meeting really lit a fire within me. We need to engage with early career clinicians and provide them the same exposure and encouragement that I received.

To instill this fire in the next generation, I encourage each of our established members, years (or decades) into their careers, to pass along their expertise to someone who is just starting out, whether it be a trainee or a junior faculty member. If this applies to you: encourage a new attending who has never been to a CHEST event to attend with you; invite a fellow or resident to submit an abstract or case report to the journal CHEST® with your oversight; or simply volunteer to speak at your medical school or residency program about why you chose PCCM and the career it has given you.

Think back to when you were embarking on your journey toward where you are now – what would it have meant to be able to get career advice or even just a friendly conversation started with someone at your current level?
 

CHEST offerings and accreditations

Beyond bringing someone to a CHEST Annual Meeting – which you should definitely do – work with your learners at medical schools and residency programs to expose them to CHEST much earlier in their careers. The Trainings and Transitions Committee is an excellent resource to guide newer clinicians and can provide a vital source of encouragement and support. If your institution doesn’t have a simulation learning center or if it has limited offerings, the hands-on learning opportunities offered at CHEST headquarters may be a fit. Accredited by the Society for Simulation in Healthcare (SSH) and the Accreditation Council for Continuing Medical Education (ACCME), CHEST currently offers 24 courses with four new courses planned for 2023 in a wide variety of areas, including courses on ultrasound and bronchoscopy.

There are so many ways to introduce early career clinicians to CHEST, and it can begin with one personal outreach. If you are working on a project for CHEST right now, consider inviting an early career clinician to join you on it – this may be the opportunity that will change their career. It did for me.

As medical professionals, each of us plays an important role in the future of medicine, and the CHEST organization can bring us together to strengthen our impact.

If you are interested in brainstorming ideas for how to engage your medical students, residents, or fellows, please feel free to contact me or anyone at CHEST to help create a plan.

I look forward to the next time we connect.

Doreen J. Addrizzo-Harris, MD, FCCP

CHEST President

Here we are, 1 month into the new year, and it already feels like my time as President of the American College of Chest Physicians will pass too quickly. One of my goals is to share some thoughts on issues important to our profession by contributing quarterly to CHEST Physician. CHEST has always been like an extended family to me, and I look forward to having this regular touchpoint with all of you.

For my first written contribution, I want to focus on the future of medicine through medical education and involvement in professional associations because I am, at heart, a medical educator.

During my address at the CHEST Annual Meeting 2022, I spoke on how CHEST provided me with networking, mentoring, and volunteer opportunities that were critical in advancing my career. Those same opportunities should be extended to everyone in pulmonary, critical care, and sleep medicine – whether a current member or prospective member.
 

Lighting a fire

Attending my first CHEST Annual Meeting was possible due to my nomination for a leadership development course. The connections I made during the meeting really lit a fire within me. We need to engage with early career clinicians and provide them the same exposure and encouragement that I received.

To instill this fire in the next generation, I encourage each of our established members, years (or decades) into their careers, to pass along their expertise to someone who is just starting out, whether it be a trainee or a junior faculty member. If this applies to you: encourage a new attending who has never been to a CHEST event to attend with you; invite a fellow or resident to submit an abstract or case report to the journal CHEST® with your oversight; or simply volunteer to speak at your medical school or residency program about why you chose PCCM and the career it has given you.

Think back to when you were embarking on your journey toward where you are now – what would it have meant to be able to get career advice or even just a friendly conversation started with someone at your current level?
 

CHEST offerings and accreditations

Beyond bringing someone to a CHEST Annual Meeting – which you should definitely do – work with your learners at medical schools and residency programs to expose them to CHEST much earlier in their careers. The Trainings and Transitions Committee is an excellent resource to guide newer clinicians and can provide a vital source of encouragement and support. If your institution doesn’t have a simulation learning center or if it has limited offerings, the hands-on learning opportunities offered at CHEST headquarters may be a fit. Accredited by the Society for Simulation in Healthcare (SSH) and the Accreditation Council for Continuing Medical Education (ACCME), CHEST currently offers 24 courses with four new courses planned for 2023 in a wide variety of areas, including courses on ultrasound and bronchoscopy.

There are so many ways to introduce early career clinicians to CHEST, and it can begin with one personal outreach. If you are working on a project for CHEST right now, consider inviting an early career clinician to join you on it – this may be the opportunity that will change their career. It did for me.

As medical professionals, each of us plays an important role in the future of medicine, and the CHEST organization can bring us together to strengthen our impact.

If you are interested in brainstorming ideas for how to engage your medical students, residents, or fellows, please feel free to contact me or anyone at CHEST to help create a plan.

I look forward to the next time we connect.

Doreen J. Addrizzo-Harris, MD, FCCP

CHEST President

AGA’s venture capital fund, the GI Opportunity Fund 1, recently announced it will be investing in EndoSound^®, a company that made waves as the winner of the 2022 AGA Shark Tank competition.

EndoSound is an Oregon-based medical device innovator developing technology that enhances access, reduces costs, and increases the safety of endoscopic ultrasound (EUS) procedures.

The EndoSound Vision System^® (EVS^®) is a disruptive EUS platform. Its attachable transducer and supportive components transform a conventional upper endoscope into a fully functional endoscopic ultrasound device. The cost of existing EUS systems has limited the availability of this crucial modality in the United States and around the world.

By reducing this cost, the EVS will provide physicians with a technological option that can enable care for their patients in a greater number of locations and settings. This brings the potential for enormous benefits to patients, payers, and providers by reducing costs in the healthcare system.

AGA’s venture capital fund, the GI Opportunity Fund 1, recently announced it will be investing in EndoSound^®, a company that made waves as the winner of the 2022 AGA Shark Tank competition.

EndoSound is an Oregon-based medical device innovator developing technology that enhances access, reduces costs, and increases the safety of endoscopic ultrasound (EUS) procedures.

The EndoSound Vision System^® (EVS^®) is a disruptive EUS platform. Its attachable transducer and supportive components transform a conventional upper endoscope into a fully functional endoscopic ultrasound device. The cost of existing EUS systems has limited the availability of this crucial modality in the United States and around the world.

By reducing this cost, the EVS will provide physicians with a technological option that can enable care for their patients in a greater number of locations and settings. This brings the potential for enormous benefits to patients, payers, and providers by reducing costs in the healthcare system.

AGA’s venture capital fund, the GI Opportunity Fund 1, recently announced it will be investing in EndoSound^®, a company that made waves as the winner of the 2022 AGA Shark Tank competition.

EndoSound is an Oregon-based medical device innovator developing technology that enhances access, reduces costs, and increases the safety of endoscopic ultrasound (EUS) procedures.

The EndoSound Vision System^® (EVS^®) is a disruptive EUS platform. Its attachable transducer and supportive components transform a conventional upper endoscope into a fully functional endoscopic ultrasound device. The cost of existing EUS systems has limited the availability of this crucial modality in the United States and around the world.

By reducing this cost, the EVS will provide physicians with a technological option that can enable care for their patients in a greater number of locations and settings. This brings the potential for enormous benefits to patients, payers, and providers by reducing costs in the healthcare system.

Did you know you can honor a family member, friend, or colleague through a gift to the AGA Research Foundation? Your gift will honor a loved one and support the AGA Research Awards Program, while giving you a tax benefit.

• Giving now or later. Any charitable gift can be made in honor or memory of someone.
• A gift today. An outright gift will help fund the AGA Research Awards Program. Your gift will assist in furthering basic digestive disease research, which can ultimately advance research into all digestive diseases. The financial benefits include an income tax deduction and possible elimination of capital gains tax.
• A gift through your will or living trust. You can include a bequest in your will or living trust stating that a specific asset, certain dollar amount, or more commonly a percentage of your estate will pass to the AGA Research Foundation at your death in honor of your loved one.
• Named opportunities. Individuals interested in receiving name recognition for a listed AGA Institute program can do so by contributing a new, unrestricted gift to the AGA Research Foundation. The gift can be payable over five years. Endowed opportunities are also available.

Your next step

An honorary gift is a wonderful way to acknowledge someone’s vision for the future. To learn more about ways to recognize your honoree, visit our website.

Did you know you can honor a family member, friend, or colleague through a gift to the AGA Research Foundation? Your gift will honor a loved one and support the AGA Research Awards Program, while giving you a tax benefit.

• Giving now or later. Any charitable gift can be made in honor or memory of someone.
• A gift today. An outright gift will help fund the AGA Research Awards Program. Your gift will assist in furthering basic digestive disease research, which can ultimately advance research into all digestive diseases. The financial benefits include an income tax deduction and possible elimination of capital gains tax.
• A gift through your will or living trust. You can include a bequest in your will or living trust stating that a specific asset, certain dollar amount, or more commonly a percentage of your estate will pass to the AGA Research Foundation at your death in honor of your loved one.
• Named opportunities. Individuals interested in receiving name recognition for a listed AGA Institute program can do so by contributing a new, unrestricted gift to the AGA Research Foundation. The gift can be payable over five years. Endowed opportunities are also available.

Your next step

An honorary gift is a wonderful way to acknowledge someone’s vision for the future. To learn more about ways to recognize your honoree, visit our website.

Did you know you can honor a family member, friend, or colleague through a gift to the AGA Research Foundation? Your gift will honor a loved one and support the AGA Research Awards Program, while giving you a tax benefit.

• Giving now or later. Any charitable gift can be made in honor or memory of someone.
• A gift today. An outright gift will help fund the AGA Research Awards Program. Your gift will assist in furthering basic digestive disease research, which can ultimately advance research into all digestive diseases. The financial benefits include an income tax deduction and possible elimination of capital gains tax.
• A gift through your will or living trust. You can include a bequest in your will or living trust stating that a specific asset, certain dollar amount, or more commonly a percentage of your estate will pass to the AGA Research Foundation at your death in honor of your loved one.
• Named opportunities. Individuals interested in receiving name recognition for a listed AGA Institute program can do so by contributing a new, unrestricted gift to the AGA Research Foundation. The gift can be payable over five years. Endowed opportunities are also available.

Your next step

An honorary gift is a wonderful way to acknowledge someone’s vision for the future. To learn more about ways to recognize your honoree, visit our website.

Congress filed its $1.7 trillion omnibus appropriations bill. The bill included positive news for GI and showcased the power of your voice in advocating for patient issues.

Here’s what you need to know:

Medicare payment cuts

Unfortunately, physicians treating Medicare patients will face cuts in the new year.

It is disappointing that Congress failed to stop the full cuts. However, the Medicare payment cuts will be lower than the initially proposed 8.5% cut. Physicians will face a 2% cut because of the 4% in PAYGO relief for 2023 and 2024, plus an additional 2.5% in relief for the Centers for Medicare & Medicaid Services.

This is not an ideal outcome, but we are grateful to the more than 160 AGA members who raised their voices and sent over 600 messages to Congress. Your advocacy played a role in alleviating the final number of the cuts.

We will continue to urge Congress to stop the full cuts. Our top priority in 2023 remains addressing the Medicare reimbursement rates.
 

Two-year extension for telehealth

Good news! We have been ongoing supporters of telehealth expansion that resulted from the COVID-19 pandemic. The inclusion of this 2-year telehealth extension will allow doctors to continue to treat Medicare patients in a virtual setting. This is crucial since it allows patients to continue receiving treatment from their doctor in a virtual setting, and it provides patients and providers with certainty.

$2.5 billion increase for NIH

Good news! The omnibus allocates $47.5 billion for the National Institutes of Health’s budget, a $2.5 billion increase from 2023. The increased federal research funding is something we advocated for with congressional offices during Advocacy Day and will support GI researchers who are conducting innovative research and developing treatment for digestive diseases and GI cancers.
 

AGA-submitted report language on IBD included

Good news! Two language requests submitted by AGA on inflammatory bowel disease (IBD) were included in the omnibus: one in the 2023 Department of Labor, Health and Human Services, Education and Related Agencies funding bill and one in the 2023 Department of Agriculture, Rural Development, Food and Drug Administration and Related Agencies funding bill.

The first reaffirms the Appropriations Committee’s support for the NIH in funding basic, translational, and clinical studies on the diagnosis and treatment of IBD. The second encourages the FDA to improve diversity and patient-centricity in IBD clinical trials. The inclusion of these language requests in the omnibus highlights another successful advocacy effort by AGA.

Congress filed its $1.7 trillion omnibus appropriations bill. The bill included positive news for GI and showcased the power of your voice in advocating for patient issues.

Here’s what you need to know:

Medicare payment cuts

Unfortunately, physicians treating Medicare patients will face cuts in the new year.

It is disappointing that Congress failed to stop the full cuts. However, the Medicare payment cuts will be lower than the initially proposed 8.5% cut. Physicians will face a 2% cut because of the 4% in PAYGO relief for 2023 and 2024, plus an additional 2.5% in relief for the Centers for Medicare & Medicaid Services.

This is not an ideal outcome, but we are grateful to the more than 160 AGA members who raised their voices and sent over 600 messages to Congress. Your advocacy played a role in alleviating the final number of the cuts.

We will continue to urge Congress to stop the full cuts. Our top priority in 2023 remains addressing the Medicare reimbursement rates.
 

Two-year extension for telehealth

Good news! We have been ongoing supporters of telehealth expansion that resulted from the COVID-19 pandemic. The inclusion of this 2-year telehealth extension will allow doctors to continue to treat Medicare patients in a virtual setting. This is crucial since it allows patients to continue receiving treatment from their doctor in a virtual setting, and it provides patients and providers with certainty.

$2.5 billion increase for NIH

Good news! The omnibus allocates $47.5 billion for the National Institutes of Health’s budget, a $2.5 billion increase from 2023. The increased federal research funding is something we advocated for with congressional offices during Advocacy Day and will support GI researchers who are conducting innovative research and developing treatment for digestive diseases and GI cancers.
 

AGA-submitted report language on IBD included

Good news! Two language requests submitted by AGA on inflammatory bowel disease (IBD) were included in the omnibus: one in the 2023 Department of Labor, Health and Human Services, Education and Related Agencies funding bill and one in the 2023 Department of Agriculture, Rural Development, Food and Drug Administration and Related Agencies funding bill.

The first reaffirms the Appropriations Committee’s support for the NIH in funding basic, translational, and clinical studies on the diagnosis and treatment of IBD. The second encourages the FDA to improve diversity and patient-centricity in IBD clinical trials. The inclusion of these language requests in the omnibus highlights another successful advocacy effort by AGA.

Congress filed its $1.7 trillion omnibus appropriations bill. The bill included positive news for GI and showcased the power of your voice in advocating for patient issues.

Here’s what you need to know:

Medicare payment cuts

Unfortunately, physicians treating Medicare patients will face cuts in the new year.

It is disappointing that Congress failed to stop the full cuts. However, the Medicare payment cuts will be lower than the initially proposed 8.5% cut. Physicians will face a 2% cut because of the 4% in PAYGO relief for 2023 and 2024, plus an additional 2.5% in relief for the Centers for Medicare & Medicaid Services.

This is not an ideal outcome, but we are grateful to the more than 160 AGA members who raised their voices and sent over 600 messages to Congress. Your advocacy played a role in alleviating the final number of the cuts.

We will continue to urge Congress to stop the full cuts. Our top priority in 2023 remains addressing the Medicare reimbursement rates.
 

Two-year extension for telehealth

Good news! We have been ongoing supporters of telehealth expansion that resulted from the COVID-19 pandemic. The inclusion of this 2-year telehealth extension will allow doctors to continue to treat Medicare patients in a virtual setting. This is crucial since it allows patients to continue receiving treatment from their doctor in a virtual setting, and it provides patients and providers with certainty.

$2.5 billion increase for NIH

Good news! The omnibus allocates $47.5 billion for the National Institutes of Health’s budget, a $2.5 billion increase from 2023. The increased federal research funding is something we advocated for with congressional offices during Advocacy Day and will support GI researchers who are conducting innovative research and developing treatment for digestive diseases and GI cancers.
 

AGA-submitted report language on IBD included

Good news! Two language requests submitted by AGA on inflammatory bowel disease (IBD) were included in the omnibus: one in the 2023 Department of Labor, Health and Human Services, Education and Related Agencies funding bill and one in the 2023 Department of Agriculture, Rural Development, Food and Drug Administration and Related Agencies funding bill.

The first reaffirms the Appropriations Committee’s support for the NIH in funding basic, translational, and clinical studies on the diagnosis and treatment of IBD. The second encourages the FDA to improve diversity and patient-centricity in IBD clinical trials. The inclusion of these language requests in the omnibus highlights another successful advocacy effort by AGA.

One mark of an excellent clinician is their commitment to lifelong learning, and CHEST’s hands-on simulation courses offer the chance for practitioners of all experience levels to enhance their knowledge.

A variety of interactive courses are offered at CHEST’s state-of-the-art Innovation, Simulation, and Training Center in Glenview, Illinois, covering topics like ultrasonography, bronchoscopy, and mechanical ventilation. And this year, our simulation schedule will offer several new sessions on advances in invasive and noninvasive ventilation, critical care transesophageal echocardiography, master-level EBUS practice, and mechanical circulatory support.

Each course is led by expert instructors and includes attendees from a full range of career stages, from trainees and mid-career clinicians to long-time CHEST faculty members.

At a fall 2022 session of the Ultrasonography: Essentials in Critical Care course, Adil Ahmed, MD, an intern at the University of Texas Health Science Center at San Antonio, shared his perspective attending as a resident.

“CHEST has lots of specialized resources and renowned faculty members, and they’re doing an exceptional job,” he said. “A lot of the things I’ve learned in the first workshop alone are completely brand new to me. I think more programs should start sending residents to these courses.”

Trainees don’t just attend simulation courses – they teach them, too. Carmen Mei, MD, a pulmonary and critical care fellow at Rutgers University, was a faculty member at the recent ultrasound course. She taught attendees representing a wide array of ages.

“It’s a learning environment. Everybody’s very engaged, no matter where they are in their career,” she said.

As a mid-career clinician, Yonatan Y. Greenstein, MD, FCCP – who serves as a co-chair of the ultrasonography course – appreciates the diversity of experiences among attendees.

“Over the years, we’ve found that the wide breadth enhances the course because learners appreciate the questions that are brought up from different angles,” he said.

For experienced clinicians like CHEST Immediate Past President David Schulman, MD, MPH, FCCP, the interactive courses provide an opportunity to continue expanding his expertise. At the ultrasound course, Dr. Schulman said he enjoyed the chance to extend and refine his skillset alongside clinicians with a broad range of experience levels.

“Ultrasound is one of those skills that many clinicians, even in their forties and older, have never trained in. It’s great to see how the more junior learners approach this with a very excited mindset, and they’re learning right beside mid-career faculty who didn’t have the exposure to ultrasound when they were young,” he said.

To find the simulation course that’s the best fit for your practice, visit chestnet.org/simulation.

One mark of an excellent clinician is their commitment to lifelong learning, and CHEST’s hands-on simulation courses offer the chance for practitioners of all experience levels to enhance their knowledge.

A variety of interactive courses are offered at CHEST’s state-of-the-art Innovation, Simulation, and Training Center in Glenview, Illinois, covering topics like ultrasonography, bronchoscopy, and mechanical ventilation. And this year, our simulation schedule will offer several new sessions on advances in invasive and noninvasive ventilation, critical care transesophageal echocardiography, master-level EBUS practice, and mechanical circulatory support.

Each course is led by expert instructors and includes attendees from a full range of career stages, from trainees and mid-career clinicians to long-time CHEST faculty members.

At a fall 2022 session of the Ultrasonography: Essentials in Critical Care course, Adil Ahmed, MD, an intern at the University of Texas Health Science Center at San Antonio, shared his perspective attending as a resident.

“CHEST has lots of specialized resources and renowned faculty members, and they’re doing an exceptional job,” he said. “A lot of the things I’ve learned in the first workshop alone are completely brand new to me. I think more programs should start sending residents to these courses.”

Trainees don’t just attend simulation courses – they teach them, too. Carmen Mei, MD, a pulmonary and critical care fellow at Rutgers University, was a faculty member at the recent ultrasound course. She taught attendees representing a wide array of ages.

“It’s a learning environment. Everybody’s very engaged, no matter where they are in their career,” she said.

As a mid-career clinician, Yonatan Y. Greenstein, MD, FCCP – who serves as a co-chair of the ultrasonography course – appreciates the diversity of experiences among attendees.

“Over the years, we’ve found that the wide breadth enhances the course because learners appreciate the questions that are brought up from different angles,” he said.

For experienced clinicians like CHEST Immediate Past President David Schulman, MD, MPH, FCCP, the interactive courses provide an opportunity to continue expanding his expertise. At the ultrasound course, Dr. Schulman said he enjoyed the chance to extend and refine his skillset alongside clinicians with a broad range of experience levels.

“Ultrasound is one of those skills that many clinicians, even in their forties and older, have never trained in. It’s great to see how the more junior learners approach this with a very excited mindset, and they’re learning right beside mid-career faculty who didn’t have the exposure to ultrasound when they were young,” he said.

To find the simulation course that’s the best fit for your practice, visit chestnet.org/simulation.

One mark of an excellent clinician is their commitment to lifelong learning, and CHEST’s hands-on simulation courses offer the chance for practitioners of all experience levels to enhance their knowledge.

A variety of interactive courses are offered at CHEST’s state-of-the-art Innovation, Simulation, and Training Center in Glenview, Illinois, covering topics like ultrasonography, bronchoscopy, and mechanical ventilation. And this year, our simulation schedule will offer several new sessions on advances in invasive and noninvasive ventilation, critical care transesophageal echocardiography, master-level EBUS practice, and mechanical circulatory support.

Each course is led by expert instructors and includes attendees from a full range of career stages, from trainees and mid-career clinicians to long-time CHEST faculty members.

At a fall 2022 session of the Ultrasonography: Essentials in Critical Care course, Adil Ahmed, MD, an intern at the University of Texas Health Science Center at San Antonio, shared his perspective attending as a resident.

“CHEST has lots of specialized resources and renowned faculty members, and they’re doing an exceptional job,” he said. “A lot of the things I’ve learned in the first workshop alone are completely brand new to me. I think more programs should start sending residents to these courses.”

Trainees don’t just attend simulation courses – they teach them, too. Carmen Mei, MD, a pulmonary and critical care fellow at Rutgers University, was a faculty member at the recent ultrasound course. She taught attendees representing a wide array of ages.

“It’s a learning environment. Everybody’s very engaged, no matter where they are in their career,” she said.

As a mid-career clinician, Yonatan Y. Greenstein, MD, FCCP – who serves as a co-chair of the ultrasonography course – appreciates the diversity of experiences among attendees.

“Over the years, we’ve found that the wide breadth enhances the course because learners appreciate the questions that are brought up from different angles,” he said.

For experienced clinicians like CHEST Immediate Past President David Schulman, MD, MPH, FCCP, the interactive courses provide an opportunity to continue expanding his expertise. At the ultrasound course, Dr. Schulman said he enjoyed the chance to extend and refine his skillset alongside clinicians with a broad range of experience levels.

“Ultrasound is one of those skills that many clinicians, even in their forties and older, have never trained in. It’s great to see how the more junior learners approach this with a very excited mindset, and they’re learning right beside mid-career faculty who didn’t have the exposure to ultrasound when they were young,” he said.

To find the simulation course that’s the best fit for your practice, visit chestnet.org/simulation.