Drug Therapy

L. Bernardo Menajovsky, MD, MS
Jefferson Antithrombotic Therapy Service, Department of Internal Medicine, Thomas Jefferson University, Philadelphia, PA

John Spandorfer, MD
Jefferson Antithrombotic Therapy Service, Department of Internal Medicine, Thomas Jefferson University, Philadelphia, PA

Address: L. Bernardo Menajovsky, MD, MS, Thomas Jefferson Thomas Jefferson University Hospital, 833 Chestnut Street East, Suite 701, Philadelphia, PA 19107; e-mail [email protected]

Dr. Menajovsky has indicated that he is on the speakers’ bureau of the Aventis corporation.

Dr. Spandorfer has indicated that he has received grant or research support from the Aventis and Astra Zeneca corporations and is on the speakers’ bureaus of the Aventis and Astra Zeneca corporations.

This paper discusses therapies that are experimental or that are not approved by the US Food and Drug Administration for the use under discussion.

L. Bernardo Menajovsky, MD, MS
Jefferson Antithrombotic Therapy Service, Department of Internal Medicine, Thomas Jefferson University, Philadelphia, PA

John Spandorfer, MD
Jefferson Antithrombotic Therapy Service, Department of Internal Medicine, Thomas Jefferson University, Philadelphia, PA

Address: L. Bernardo Menajovsky, MD, MS, Thomas Jefferson Thomas Jefferson University Hospital, 833 Chestnut Street East, Suite 701, Philadelphia, PA 19107; e-mail [email protected]

Dr. Menajovsky has indicated that he is on the speakers’ bureau of the Aventis corporation.

Dr. Spandorfer has indicated that he has received grant or research support from the Aventis and Astra Zeneca corporations and is on the speakers’ bureaus of the Aventis and Astra Zeneca corporations.

This paper discusses therapies that are experimental or that are not approved by the US Food and Drug Administration for the use under discussion.

L. Bernardo Menajovsky, MD, MS
Jefferson Antithrombotic Therapy Service, Department of Internal Medicine, Thomas Jefferson University, Philadelphia, PA

John Spandorfer, MD
Jefferson Antithrombotic Therapy Service, Department of Internal Medicine, Thomas Jefferson University, Philadelphia, PA

Address: L. Bernardo Menajovsky, MD, MS, Thomas Jefferson Thomas Jefferson University Hospital, 833 Chestnut Street East, Suite 701, Philadelphia, PA 19107; e-mail [email protected]

Dr. Menajovsky has indicated that he is on the speakers’ bureau of the Aventis corporation.

Dr. Spandorfer has indicated that he has received grant or research support from the Aventis and Astra Zeneca corporations and is on the speakers’ bureaus of the Aventis and Astra Zeneca corporations.

This paper discusses therapies that are experimental or that are not approved by the US Food and Drug Administration for the use under discussion.

Juhana Karha, MD
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation

Eric J. Topol, MD
Chairman, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation

Address: Eric J. Topol, MD, Chairman, Department of Cardiovascular Medicine, F25, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected]

Juhana Karha, MD
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation

Eric J. Topol, MD
Chairman, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation

Address: Eric J. Topol, MD, Chairman, Department of Cardiovascular Medicine, F25, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected]

Juhana Karha, MD
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation

Eric J. Topol, MD
Chairman, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation

Address: Eric J. Topol, MD, Chairman, Department of Cardiovascular Medicine, F25, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected]

Sharon K. Inouye, MD, MPH
Department of Internal Medicine, Yale University School of Medicine

Address: Sharon K Inouye, MD, MPH, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street (DC013K), PO Box 208025, New Haven, CT 06520

This paper was adapted from a presentation given by Dr. Inouye as Visiting Professor Pro Tempore, Department of Medicine, Case Western Reserve University and The Cleveland Clinic Educational Foundation.

Medical Grand Rounds articles are approved by the author but are not peer-reviewed.

Sharon K. Inouye, MD, MPH
Department of Internal Medicine, Yale University School of Medicine

Address: Sharon K Inouye, MD, MPH, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street (DC013K), PO Box 208025, New Haven, CT 06520

This paper was adapted from a presentation given by Dr. Inouye as Visiting Professor Pro Tempore, Department of Medicine, Case Western Reserve University and The Cleveland Clinic Educational Foundation.

Medical Grand Rounds articles are approved by the author but are not peer-reviewed.

Sharon K. Inouye, MD, MPH
Department of Internal Medicine, Yale University School of Medicine

Address: Sharon K Inouye, MD, MPH, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street (DC013K), PO Box 208025, New Haven, CT 06520

This paper was adapted from a presentation given by Dr. Inouye as Visiting Professor Pro Tempore, Department of Medicine, Case Western Reserve University and The Cleveland Clinic Educational Foundation.

Medical Grand Rounds articles are approved by the author but are not peer-reviewed.

Carl K. Gjertson, MD
Department of Urology, College of Physicians and Surgeons, Columbia University, New York

Konstantin Walmsley, MD
Department of Urology, College of Physicians and Surgeons, Columbia University, New York

Steven A. Kaplan, MD
Department of Urology, College of Physicians and Surgeons, Columbia University, New York

Address: Steven A. Kaplan, MD, Department of Urology, College of Physicians and Surgeons, Columbia University, Irving Pavilion, 11th floor, 161 Fort Washington Avenue, New York, NY 10032; e-mail [email protected]

Dr. Kaplan has indicated that he has received grant or research support from the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health, and that he is on the speakers’ bureaus of the Merck, Glaxo, Boehringer Ingelheim, and Sanofi corporations.

Carl K. Gjertson, MD
Department of Urology, College of Physicians and Surgeons, Columbia University, New York

Konstantin Walmsley, MD
Department of Urology, College of Physicians and Surgeons, Columbia University, New York

Steven A. Kaplan, MD
Department of Urology, College of Physicians and Surgeons, Columbia University, New York

Address: Steven A. Kaplan, MD, Department of Urology, College of Physicians and Surgeons, Columbia University, Irving Pavilion, 11th floor, 161 Fort Washington Avenue, New York, NY 10032; e-mail [email protected]

Dr. Kaplan has indicated that he has received grant or research support from the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health, and that he is on the speakers’ bureaus of the Merck, Glaxo, Boehringer Ingelheim, and Sanofi corporations.

Carl K. Gjertson, MD
Department of Urology, College of Physicians and Surgeons, Columbia University, New York

Konstantin Walmsley, MD
Department of Urology, College of Physicians and Surgeons, Columbia University, New York

Steven A. Kaplan, MD
Department of Urology, College of Physicians and Surgeons, Columbia University, New York

Address: Steven A. Kaplan, MD, Department of Urology, College of Physicians and Surgeons, Columbia University, Irving Pavilion, 11th floor, 161 Fort Washington Avenue, New York, NY 10032; e-mail [email protected]

Dr. Kaplan has indicated that he has received grant or research support from the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health, and that he is on the speakers’ bureaus of the Merck, Glaxo, Boehringer Ingelheim, and Sanofi corporations.

Brian F. Mandell, MD, PhD
Deputy Editor

Brian F. Mandell, MD, PhD
Deputy Editor

Brian F. Mandell, MD, PhD
Deputy Editor

Lee S. Simon, MD
Associate Clinical Professor of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA

Vibeke Strand, MD
Adjunct Clinical Professor of Medicine, Stanford University School of Medicine, Stanford, CA

Address: Lee S. Simon, MD, Associate Clinical Professor of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, 110 Francis St, Suite 4B, Boston, MA; e-mail [email protected]

Dr. Simon has indicated that he has been an investigator and consultant for and has received honoraria from GD Searle, Pharmacia, and Pfizer. He serves as a consultant in drug development for TAP Pharmaceuticals, Sanofi Aventis, AlphaRx, Synta Pharmaceuticals, Roche, Millenium, Cypress, Forrest, Pierre Fabre, Omeros, and Pfizer.

Dr. Strand has indicated that she has worked as an independent consultant for Abbott Immunology, Abgenix, Amgen, Biogen Idec, Celltech, Centocor, Enzon, Genelabs, Genentech, Hoffman, Incyte, La Jolla Pharmaceuticals, Millenium, Novartis, Omeros, Organon, Pfizer Research, Sanofi Aventis, Scios, Serono, SKK, and Sumitomo corporations. She has served on advisory boards for Abbott, Abgenix, Amgen, Aventis, Centocor, Lilly, RWJ Pharmaceutical Research Institute, Roche, Novartis, and Pfizer. She serves on the speakers’ bureaus for Abbott, Amgen, Sanofi Aventis, and Pfizer.

Lee S. Simon, MD
Associate Clinical Professor of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA

Vibeke Strand, MD
Adjunct Clinical Professor of Medicine, Stanford University School of Medicine, Stanford, CA

Address: Lee S. Simon, MD, Associate Clinical Professor of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, 110 Francis St, Suite 4B, Boston, MA; e-mail [email protected]

Dr. Simon has indicated that he has been an investigator and consultant for and has received honoraria from GD Searle, Pharmacia, and Pfizer. He serves as a consultant in drug development for TAP Pharmaceuticals, Sanofi Aventis, AlphaRx, Synta Pharmaceuticals, Roche, Millenium, Cypress, Forrest, Pierre Fabre, Omeros, and Pfizer.

Dr. Strand has indicated that she has worked as an independent consultant for Abbott Immunology, Abgenix, Amgen, Biogen Idec, Celltech, Centocor, Enzon, Genelabs, Genentech, Hoffman, Incyte, La Jolla Pharmaceuticals, Millenium, Novartis, Omeros, Organon, Pfizer Research, Sanofi Aventis, Scios, Serono, SKK, and Sumitomo corporations. She has served on advisory boards for Abbott, Abgenix, Amgen, Aventis, Centocor, Lilly, RWJ Pharmaceutical Research Institute, Roche, Novartis, and Pfizer. She serves on the speakers’ bureaus for Abbott, Amgen, Sanofi Aventis, and Pfizer.

Lee S. Simon, MD
Associate Clinical Professor of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA

Vibeke Strand, MD
Adjunct Clinical Professor of Medicine, Stanford University School of Medicine, Stanford, CA

Address: Lee S. Simon, MD, Associate Clinical Professor of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, 110 Francis St, Suite 4B, Boston, MA; e-mail [email protected]

Dr. Simon has indicated that he has been an investigator and consultant for and has received honoraria from GD Searle, Pharmacia, and Pfizer. He serves as a consultant in drug development for TAP Pharmaceuticals, Sanofi Aventis, AlphaRx, Synta Pharmaceuticals, Roche, Millenium, Cypress, Forrest, Pierre Fabre, Omeros, and Pfizer.

Dr. Strand has indicated that she has worked as an independent consultant for Abbott Immunology, Abgenix, Amgen, Biogen Idec, Celltech, Centocor, Enzon, Genelabs, Genentech, Hoffman, Incyte, La Jolla Pharmaceuticals, Millenium, Novartis, Omeros, Organon, Pfizer Research, Sanofi Aventis, Scios, Serono, SKK, and Sumitomo corporations. She has served on advisory boards for Abbott, Abgenix, Amgen, Aventis, Centocor, Lilly, RWJ Pharmaceutical Research Institute, Roche, Novartis, and Pfizer. She serves on the speakers’ bureaus for Abbott, Amgen, Sanofi Aventis, and Pfizer.

John D. Clough, MD
Editor in Chief

John D. Clough, MD
Editor in Chief

John D. Clough, MD
Editor in Chief

Cameron Haery, MD
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation

Ravish Sachar, MD
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation

Stephen G. Ellis, MD
Director, Sones Catheterization Laboratories, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation

Address: Stephen G. Ellis, MD, Director, Sones Catheterization Laboratories, F25, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected]

Dr. Ellis has indicated that he has received grant or research support from the Cordis and Medtronic corporations and serves as a consultant for the Cordis, Boston Scientific, and Guidant corporations.

This paper discusses therapies that are experimental or that are not approved by the US Food and Drug Administration for the use under discussion.

Cameron Haery, MD
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation

Ravish Sachar, MD
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation

Stephen G. Ellis, MD
Director, Sones Catheterization Laboratories, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation

Address: Stephen G. Ellis, MD, Director, Sones Catheterization Laboratories, F25, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected]

Dr. Ellis has indicated that he has received grant or research support from the Cordis and Medtronic corporations and serves as a consultant for the Cordis, Boston Scientific, and Guidant corporations.

This paper discusses therapies that are experimental or that are not approved by the US Food and Drug Administration for the use under discussion.

Cameron Haery, MD
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation

Ravish Sachar, MD
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation

Stephen G. Ellis, MD
Director, Sones Catheterization Laboratories, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation

Address: Stephen G. Ellis, MD, Director, Sones Catheterization Laboratories, F25, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail [email protected]

Dr. Ellis has indicated that he has received grant or research support from the Cordis and Medtronic corporations and serves as a consultant for the Cordis, Boston Scientific, and Guidant corporations.

This paper discusses therapies that are experimental or that are not approved by the US Food and Drug Administration for the use under discussion.

John W. Hirshfeld, Jr., MD
The Cardiac Catheterization Laboratory, University of Pennsylvania Medical Center, Philadelphia

Robert L. Wilensky, MD
The Cardiac Catheterization Laboratory, University of Pennsylvania Medical Center, Philadelphia

Address: John W. Hirshfeld, Jr., MD, Cardiac Catheterization Laboratory, 9.119 Founders Pavilion, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104; e-mail [email protected]

John W. Hirshfeld, Jr., MD
The Cardiac Catheterization Laboratory, University of Pennsylvania Medical Center, Philadelphia

Robert L. Wilensky, MD
The Cardiac Catheterization Laboratory, University of Pennsylvania Medical Center, Philadelphia

Address: John W. Hirshfeld, Jr., MD, Cardiac Catheterization Laboratory, 9.119 Founders Pavilion, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104; e-mail [email protected]

John W. Hirshfeld, Jr., MD
The Cardiac Catheterization Laboratory, University of Pennsylvania Medical Center, Philadelphia

Robert L. Wilensky, MD
The Cardiac Catheterization Laboratory, University of Pennsylvania Medical Center, Philadelphia

Address: John W. Hirshfeld, Jr., MD, Cardiac Catheterization Laboratory, 9.119 Founders Pavilion, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104; e-mail [email protected]