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Update on therapies for lymphoproliferative disorders
Diabetes mellitus as a late effect of the treatment of Hodgkin lymphoma.1
Two recent follow-up studies of childhood cancer patients who had been treated with abdominal radiation revealed an increased risk of diabetes mellitus (DM) in the survivors. In the past, many patients with a diagnosis of Hodgkin lymphoma (HL) were also treated with infradiaphragmatic radiation. The para-aortic and splenic fields used for this treatment encompasses most of the pancreas, including the tail. Since diabetes is a risk factor for cardiovascular disease, it is conceivable that an increase in diabetes in survivors of HL might contribute to their increased risk of cardiovascular disease. In this recent study of adults, the results of the treatment of 2,352 Dutch 5-year survivors of HL treatment who were younger than 51 years at the time of diagnosis were analyzed. Detailed records of their treatment and late effects of treatment were obtained, including information about DM, hypertension, hypercholesterolemia, smoking, and obesity. Radiation dose to the pancreas was estimated.
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Issue
The Journal of Community and Supportive Oncology - 13(1)
Page Number
34-36
Legacy Keywords
Hodgkin lymphoma, RESORT trial, lymphoma, lymphocytic leukemia
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Article PDF
Diabetes mellitus as a late effect of the treatment of Hodgkin lymphoma.1
Two recent follow-up studies of childhood cancer patients who had been treated with abdominal radiation revealed an increased risk of diabetes mellitus (DM) in the survivors. In the past, many patients with a diagnosis of Hodgkin lymphoma (HL) were also treated with infradiaphragmatic radiation. The para-aortic and splenic fields used for this treatment encompasses most of the pancreas, including the tail. Since diabetes is a risk factor for cardiovascular disease, it is conceivable that an increase in diabetes in survivors of HL might contribute to their increased risk of cardiovascular disease. In this recent study of adults, the results of the treatment of 2,352 Dutch 5-year survivors of HL treatment who were younger than 51 years at the time of diagnosis were analyzed. Detailed records of their treatment and late effects of treatment were obtained, including information about DM, hypertension, hypercholesterolemia, smoking, and obesity. Radiation dose to the pancreas was estimated.
Click on the PDF icon at the top of this introduction to read the full article.
Diabetes mellitus as a late effect of the treatment of Hodgkin lymphoma.1
Two recent follow-up studies of childhood cancer patients who had been treated with abdominal radiation revealed an increased risk of diabetes mellitus (DM) in the survivors. In the past, many patients with a diagnosis of Hodgkin lymphoma (HL) were also treated with infradiaphragmatic radiation. The para-aortic and splenic fields used for this treatment encompasses most of the pancreas, including the tail. Since diabetes is a risk factor for cardiovascular disease, it is conceivable that an increase in diabetes in survivors of HL might contribute to their increased risk of cardiovascular disease. In this recent study of adults, the results of the treatment of 2,352 Dutch 5-year survivors of HL treatment who were younger than 51 years at the time of diagnosis were analyzed. Detailed records of their treatment and late effects of treatment were obtained, including information about DM, hypertension, hypercholesterolemia, smoking, and obesity. Radiation dose to the pancreas was estimated.
Click on the PDF icon at the top of this introduction to read the full article.
Issue
The Journal of Community and Supportive Oncology - 13(1)
Issue
The Journal of Community and Supportive Oncology - 13(1)
Page Number
34-36
Page Number
34-36
Article Type
Display Headline
Update on therapies for lymphoproliferative disorders
Display Headline
Update on therapies for lymphoproliferative disorders
Legacy Keywords
Hodgkin lymphoma, RESORT trial, lymphoma, lymphocytic leukemia
Legacy Keywords
Hodgkin lymphoma, RESORT trial, lymphoma, lymphocytic leukemia
Sections
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JCSO 2015;13:34-36
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