Survival correlates with response to preoperative chemotherapy in CRPM patients undergoing CRS/HIPEC

Key clinical point: In patients with colorectal peritoneal metastasis (CRPM), survival is closely related to pathological response (PR) ratio to preoperative chemotherapy in patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), with best outcomes observed in patients with complete PR (CPR).

Major finding: The rate of complications was significantly higher in the low PR (LPR; 65.2%) vsvs CPR (55%) and high PR (HPR; 42.8%; P = .03) groups. Disease-free survival was significantly higher in CPR and HPR vsvs LPR groups (P less than .001). Overall survival was significantly higher in CPR vsvs HPR and LPR groups (P = .004).

Study details: Findings are from a retrospective analysis of 178 patients with CRPM who underwent a CRS/HIPEC procedure and had a final completeness of cytoreduction score of 0. Based on the ratio of tumor-positive specimens to the total number of specimens resected, patients were categorized into CPR, HPR, and LPR groups.

Disclosures: The authors did not declare any source of funding. All the authors declared no conflicts of interest.

Source: Mor E et al. Ann Surg Oncol. 2021 Jul 7. doi: 10.1245/s10434-021-10367-6.

Key clinical point: In patients with colorectal peritoneal metastasis (CRPM), survival is closely related to pathological response (PR) ratio to preoperative chemotherapy in patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), with best outcomes observed in patients with complete PR (CPR).

Major finding: The rate of complications was significantly higher in the low PR (LPR; 65.2%) vsvs CPR (55%) and high PR (HPR; 42.8%; P = .03) groups. Disease-free survival was significantly higher in CPR and HPR vsvs LPR groups (P less than .001). Overall survival was significantly higher in CPR vsvs HPR and LPR groups (P = .004).

Study details: Findings are from a retrospective analysis of 178 patients with CRPM who underwent a CRS/HIPEC procedure and had a final completeness of cytoreduction score of 0. Based on the ratio of tumor-positive specimens to the total number of specimens resected, patients were categorized into CPR, HPR, and LPR groups.

Disclosures: The authors did not declare any source of funding. All the authors declared no conflicts of interest.

Source: Mor E et al. Ann Surg Oncol. 2021 Jul 7. doi: 10.1245/s10434-021-10367-6.

Key clinical point: In patients with colorectal peritoneal metastasis (CRPM), survival is closely related to pathological response (PR) ratio to preoperative chemotherapy in patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), with best outcomes observed in patients with complete PR (CPR).

Major finding: The rate of complications was significantly higher in the low PR (LPR; 65.2%) vsvs CPR (55%) and high PR (HPR; 42.8%; P = .03) groups. Disease-free survival was significantly higher in CPR and HPR vsvs LPR groups (P less than .001). Overall survival was significantly higher in CPR vsvs HPR and LPR groups (P = .004).

Study details: Findings are from a retrospective analysis of 178 patients with CRPM who underwent a CRS/HIPEC procedure and had a final completeness of cytoreduction score of 0. Based on the ratio of tumor-positive specimens to the total number of specimens resected, patients were categorized into CPR, HPR, and LPR groups.

Disclosures: The authors did not declare any source of funding. All the authors declared no conflicts of interest.

Source: Mor E et al. Ann Surg Oncol. 2021 Jul 7. doi: 10.1245/s10434-021-10367-6.