Studies Compare Surgical Options for Trigeminal Neuralgia

WASHINGTON – New evidence on the effectiveness of surgical options for trigeminal neuralgia points to greater safety and longer pain-free intervals when glycerol rhizotomy is used instead of balloon microcompression in patients with multiple sclerosis, as well as when the rhizotomy procedure is repeated, according to two studies reported at the annual meeting of the Congress of Neurological Surgeons.

Outcomes with a third option for trigeminal neuralgia – microvascular decompression – suggest that elderly patients have greater complications and in-hospital mortality than do younger patients.

Rhizotomy vs. Microcompression in MS. Trigeminal neuralgia occurs in about 2%-4% of patients with MS, said Dr. Grant W. Mallory, a fellow in neurological surgery at the Mayo Clinic, Rochester, Minn. Pain in these patients is more often bilateral than unilateral, and presents at a younger age than in the general population. While the majority of patients respond well to medical therapy with carbamazepine, some do require a surgical approach, he said.

Dr. Mallory and his mentor, Dr. Bruce Pollock, reviewed surgical outcomes and follow-up in 69 MS patients who underwent balloon microcompression and 68 who underwent glycerol rhizotomy during 1997-2010. The patients’ mean age was 62 years. Their mean pain duration at baseline varied significantly, between 16 months in those undergoing microcompression and 55 months in those undergoing rhizotomy. Most patients had already undergone a prior procedure (87% of the microcompression patients and 48% of the rhizotomy patients).

The investigators defined an excellent outcome as being pain free and tapered off medications. A good outcome was freedom from pain with continued medication; a failed procedure was no pain relief, or pain recurrence within 1 month.

There was a nonsignificant trend for more patients to report excellent or good pain relief after rhizotomy than after microcompression (74% vs. 65%).

Overall, pain recurred in 86% of patients after a median time of 6 months; the overall median follow-up time was 13 months. Pain recurred significantly later after rhizotomy (mean of 7 months) than after balloon microcompression (5 months). This contributed to a significant difference in the percentage of patients who needed further surgical procedures: 36% with rhizotomy vs. 44% with microcompression. Patients undergoing their first procedure had a longer time to pain recurrence than did those who had a prior intervention (10 months vs. 4 months).

"Comparing our series [of MS patients] to historical controls in patients without MS, our cohort fared substantially worse with regard to initial response rate (69% vs. 90%)," Dr. Mallory said. Historical control patients also had a pain-free interval that was about twice that of patients with MS, he said.

Complications occurred significantly more often in patients treated with balloon microcompression than with rhizotomy (17% vs. 5%). In the microcompression group, there were two cases of corneal anesthesia, one anesthesia dolorosa, five jaw deviations, four diplopias, and one each of Horne’s syndrome, dyesthesia, and thalamic hemorrhage. In the rhizotomy group there were two cases of corneal anesthesia and one case of paresthesia.

Although the study was not a randomized trial, Dr. Mallory said his mentor prefers the glycerol rhizotomy as a first-line invasive intervention in MS patients because of its low complication rate. If the patient is unable to tolerate the procedure under a local anesthetic, the surgeon may convert to a balloon microcompression under general anesthesia, Dr. Mallory said.

Repeat Rhizotomy Better Than Expected. Glycerol rhizotomy conferred greater benefit when it was repeated in patients with trigeminal neuralgia than when it was performed for the first time, according to a review of 547 patients conducted by Matthew Bender and his colleagues at Johns Hopkins University Medical Center, Baltimore.

Mr. Bender, a fourth-year medical student, reported that during 1998-2010, patients at the center who had undergone a prior rhizotomy were 21% less likely to have a failed procedure than were those who underwent an initial rhizotomy. These patients underwent 647 glycerol rhizotomies, including 504 first-time procedures.

The patients’ mean age was 64 years, and their mean duration of trigeminal neuralgia was 7 years.

All of the repeat patients had undergone at least one other rhizotomy. Ten patients in the repeat group and 13 in the initial group had previously undergone radiofrequency thermocoagulation.

The patients also had undergone other prior procedures, including intracranial stereotactic radiosurgery (11 in the initial group and 1 in the repeat group), balloon microcompression (2 in the initial group), and microvascular decompression (19 in the initial group and 10 in the repeat group).

The investigators defined the best outcome as at least 90% pain relief with no medications. They described a good outcome as at least 50% pain relief with minimal medications. Fair was defined as up to 50% pain relief with no medication change. A poor outcome was no pain relief.

Rhizotomy resulted in the best possible outcome for a significantly greater percentage of patients who had the procedure for a second time, compared with those who had it for the first time (74% vs. 65%). Good outcomes occurred in 12% of each group. Fair outcomes occurred in 10% of the initial group and 3% of the repeat group, whereas poor outcomes occurred in 13% of the initial group and 10% of the repeat group.

The overall median time to treatment failure was similar between the first-time and repeat treatment groups (27 months vs. 19 months, respectively).

"These outcomes challenge the consensus that repeat glycerol rhizotomy has decreased pain relief and durability," Mr. Bender said. "Not only can this be used as our first-line percutaneous procedure, it can be repeated before resorting to salvage modalities."

Elderly Tolerate Decompression Less. In a third study, Dr. Anand Rughani and his colleagues at the University of Vermont, Burlington, found that elderly patients do not tolerate microvascular decompression nearly as well as younger patients, based on a higher rate of in-hospital complications and mortality in the Nationwide Inpatient Sample.

Over a 10-year period in the database, Dr. Rughani and his associates found 3,273 patients who had undergone the procedure; their median age was 57 years.

The investigators examined in-hospital outcomes in patients younger than age 65 years, those who were 65-74 years old, and those who were 75 years or older.

The risk of any in-hospital complication occurring in a patient over age 65 was 7%, compared with 10% in those over age 75, a significant difference. In-hospital mortality also significantly increased as patients aged: It was 0.13% in those younger than 65 years, 0.68% in those aged 65 years or older, and about 1.5% in those aged 85 years or older.

Other complications occurred with similar frequency in patients 65 years or older and those 75 years or older: Cardiac complications occurred at a rate of 2% in both age groups; pulmonary complications in 2% and 4%, respectively; thromboembolic complications in 1% and 2%; and stroke in 3% and 4%.

"The likelihood of discharge to a nursing home or rehabilitation facility was also robustly associated with age," Dr. Rughani said. "Unfortunately, this review only captures in-hospital complications, so delayed complications like wound infections and pulmonary embolisms might not show up. This analysis could be quite an under-representation of how older patients might respond to microvascular decompression."

None of the authors of the three studies had any financial declarations.

WASHINGTON – New evidence on the effectiveness of surgical options for trigeminal neuralgia points to greater safety and longer pain-free intervals when glycerol rhizotomy is used instead of balloon microcompression in patients with multiple sclerosis, as well as when the rhizotomy procedure is repeated, according to two studies reported at the annual meeting of the Congress of Neurological Surgeons.

Outcomes with a third option for trigeminal neuralgia – microvascular decompression – suggest that elderly patients have greater complications and in-hospital mortality than do younger patients.

Rhizotomy vs. Microcompression in MS. Trigeminal neuralgia occurs in about 2%-4% of patients with MS, said Dr. Grant W. Mallory, a fellow in neurological surgery at the Mayo Clinic, Rochester, Minn. Pain in these patients is more often bilateral than unilateral, and presents at a younger age than in the general population. While the majority of patients respond well to medical therapy with carbamazepine, some do require a surgical approach, he said.

Dr. Mallory and his mentor, Dr. Bruce Pollock, reviewed surgical outcomes and follow-up in 69 MS patients who underwent balloon microcompression and 68 who underwent glycerol rhizotomy during 1997-2010. The patients’ mean age was 62 years. Their mean pain duration at baseline varied significantly, between 16 months in those undergoing microcompression and 55 months in those undergoing rhizotomy. Most patients had already undergone a prior procedure (87% of the microcompression patients and 48% of the rhizotomy patients).

The investigators defined an excellent outcome as being pain free and tapered off medications. A good outcome was freedom from pain with continued medication; a failed procedure was no pain relief, or pain recurrence within 1 month.

There was a nonsignificant trend for more patients to report excellent or good pain relief after rhizotomy than after microcompression (74% vs. 65%).

Overall, pain recurred in 86% of patients after a median time of 6 months; the overall median follow-up time was 13 months. Pain recurred significantly later after rhizotomy (mean of 7 months) than after balloon microcompression (5 months). This contributed to a significant difference in the percentage of patients who needed further surgical procedures: 36% with rhizotomy vs. 44% with microcompression. Patients undergoing their first procedure had a longer time to pain recurrence than did those who had a prior intervention (10 months vs. 4 months).

"Comparing our series [of MS patients] to historical controls in patients without MS, our cohort fared substantially worse with regard to initial response rate (69% vs. 90%)," Dr. Mallory said. Historical control patients also had a pain-free interval that was about twice that of patients with MS, he said.

Complications occurred significantly more often in patients treated with balloon microcompression than with rhizotomy (17% vs. 5%). In the microcompression group, there were two cases of corneal anesthesia, one anesthesia dolorosa, five jaw deviations, four diplopias, and one each of Horne’s syndrome, dyesthesia, and thalamic hemorrhage. In the rhizotomy group there were two cases of corneal anesthesia and one case of paresthesia.

Although the study was not a randomized trial, Dr. Mallory said his mentor prefers the glycerol rhizotomy as a first-line invasive intervention in MS patients because of its low complication rate. If the patient is unable to tolerate the procedure under a local anesthetic, the surgeon may convert to a balloon microcompression under general anesthesia, Dr. Mallory said.

Repeat Rhizotomy Better Than Expected. Glycerol rhizotomy conferred greater benefit when it was repeated in patients with trigeminal neuralgia than when it was performed for the first time, according to a review of 547 patients conducted by Matthew Bender and his colleagues at Johns Hopkins University Medical Center, Baltimore.

Mr. Bender, a fourth-year medical student, reported that during 1998-2010, patients at the center who had undergone a prior rhizotomy were 21% less likely to have a failed procedure than were those who underwent an initial rhizotomy. These patients underwent 647 glycerol rhizotomies, including 504 first-time procedures.

The patients’ mean age was 64 years, and their mean duration of trigeminal neuralgia was 7 years.

All of the repeat patients had undergone at least one other rhizotomy. Ten patients in the repeat group and 13 in the initial group had previously undergone radiofrequency thermocoagulation.

The patients also had undergone other prior procedures, including intracranial stereotactic radiosurgery (11 in the initial group and 1 in the repeat group), balloon microcompression (2 in the initial group), and microvascular decompression (19 in the initial group and 10 in the repeat group).

The investigators defined the best outcome as at least 90% pain relief with no medications. They described a good outcome as at least 50% pain relief with minimal medications. Fair was defined as up to 50% pain relief with no medication change. A poor outcome was no pain relief.

Rhizotomy resulted in the best possible outcome for a significantly greater percentage of patients who had the procedure for a second time, compared with those who had it for the first time (74% vs. 65%). Good outcomes occurred in 12% of each group. Fair outcomes occurred in 10% of the initial group and 3% of the repeat group, whereas poor outcomes occurred in 13% of the initial group and 10% of the repeat group.

The overall median time to treatment failure was similar between the first-time and repeat treatment groups (27 months vs. 19 months, respectively).

"These outcomes challenge the consensus that repeat glycerol rhizotomy has decreased pain relief and durability," Mr. Bender said. "Not only can this be used as our first-line percutaneous procedure, it can be repeated before resorting to salvage modalities."

Elderly Tolerate Decompression Less. In a third study, Dr. Anand Rughani and his colleagues at the University of Vermont, Burlington, found that elderly patients do not tolerate microvascular decompression nearly as well as younger patients, based on a higher rate of in-hospital complications and mortality in the Nationwide Inpatient Sample.

Over a 10-year period in the database, Dr. Rughani and his associates found 3,273 patients who had undergone the procedure; their median age was 57 years.

The investigators examined in-hospital outcomes in patients younger than age 65 years, those who were 65-74 years old, and those who were 75 years or older.

The risk of any in-hospital complication occurring in a patient over age 65 was 7%, compared with 10% in those over age 75, a significant difference. In-hospital mortality also significantly increased as patients aged: It was 0.13% in those younger than 65 years, 0.68% in those aged 65 years or older, and about 1.5% in those aged 85 years or older.

Other complications occurred with similar frequency in patients 65 years or older and those 75 years or older: Cardiac complications occurred at a rate of 2% in both age groups; pulmonary complications in 2% and 4%, respectively; thromboembolic complications in 1% and 2%; and stroke in 3% and 4%.

"The likelihood of discharge to a nursing home or rehabilitation facility was also robustly associated with age," Dr. Rughani said. "Unfortunately, this review only captures in-hospital complications, so delayed complications like wound infections and pulmonary embolisms might not show up. This analysis could be quite an under-representation of how older patients might respond to microvascular decompression."

None of the authors of the three studies had any financial declarations.

WASHINGTON – New evidence on the effectiveness of surgical options for trigeminal neuralgia points to greater safety and longer pain-free intervals when glycerol rhizotomy is used instead of balloon microcompression in patients with multiple sclerosis, as well as when the rhizotomy procedure is repeated, according to two studies reported at the annual meeting of the Congress of Neurological Surgeons.

Outcomes with a third option for trigeminal neuralgia – microvascular decompression – suggest that elderly patients have greater complications and in-hospital mortality than do younger patients.

Rhizotomy vs. Microcompression in MS. Trigeminal neuralgia occurs in about 2%-4% of patients with MS, said Dr. Grant W. Mallory, a fellow in neurological surgery at the Mayo Clinic, Rochester, Minn. Pain in these patients is more often bilateral than unilateral, and presents at a younger age than in the general population. While the majority of patients respond well to medical therapy with carbamazepine, some do require a surgical approach, he said.

Dr. Mallory and his mentor, Dr. Bruce Pollock, reviewed surgical outcomes and follow-up in 69 MS patients who underwent balloon microcompression and 68 who underwent glycerol rhizotomy during 1997-2010. The patients’ mean age was 62 years. Their mean pain duration at baseline varied significantly, between 16 months in those undergoing microcompression and 55 months in those undergoing rhizotomy. Most patients had already undergone a prior procedure (87% of the microcompression patients and 48% of the rhizotomy patients).

The investigators defined an excellent outcome as being pain free and tapered off medications. A good outcome was freedom from pain with continued medication; a failed procedure was no pain relief, or pain recurrence within 1 month.

There was a nonsignificant trend for more patients to report excellent or good pain relief after rhizotomy than after microcompression (74% vs. 65%).

Overall, pain recurred in 86% of patients after a median time of 6 months; the overall median follow-up time was 13 months. Pain recurred significantly later after rhizotomy (mean of 7 months) than after balloon microcompression (5 months). This contributed to a significant difference in the percentage of patients who needed further surgical procedures: 36% with rhizotomy vs. 44% with microcompression. Patients undergoing their first procedure had a longer time to pain recurrence than did those who had a prior intervention (10 months vs. 4 months).

"Comparing our series [of MS patients] to historical controls in patients without MS, our cohort fared substantially worse with regard to initial response rate (69% vs. 90%)," Dr. Mallory said. Historical control patients also had a pain-free interval that was about twice that of patients with MS, he said.

Complications occurred significantly more often in patients treated with balloon microcompression than with rhizotomy (17% vs. 5%). In the microcompression group, there were two cases of corneal anesthesia, one anesthesia dolorosa, five jaw deviations, four diplopias, and one each of Horne’s syndrome, dyesthesia, and thalamic hemorrhage. In the rhizotomy group there were two cases of corneal anesthesia and one case of paresthesia.

Although the study was not a randomized trial, Dr. Mallory said his mentor prefers the glycerol rhizotomy as a first-line invasive intervention in MS patients because of its low complication rate. If the patient is unable to tolerate the procedure under a local anesthetic, the surgeon may convert to a balloon microcompression under general anesthesia, Dr. Mallory said.

Repeat Rhizotomy Better Than Expected. Glycerol rhizotomy conferred greater benefit when it was repeated in patients with trigeminal neuralgia than when it was performed for the first time, according to a review of 547 patients conducted by Matthew Bender and his colleagues at Johns Hopkins University Medical Center, Baltimore.

Mr. Bender, a fourth-year medical student, reported that during 1998-2010, patients at the center who had undergone a prior rhizotomy were 21% less likely to have a failed procedure than were those who underwent an initial rhizotomy. These patients underwent 647 glycerol rhizotomies, including 504 first-time procedures.

The patients’ mean age was 64 years, and their mean duration of trigeminal neuralgia was 7 years.

All of the repeat patients had undergone at least one other rhizotomy. Ten patients in the repeat group and 13 in the initial group had previously undergone radiofrequency thermocoagulation.

The patients also had undergone other prior procedures, including intracranial stereotactic radiosurgery (11 in the initial group and 1 in the repeat group), balloon microcompression (2 in the initial group), and microvascular decompression (19 in the initial group and 10 in the repeat group).

The investigators defined the best outcome as at least 90% pain relief with no medications. They described a good outcome as at least 50% pain relief with minimal medications. Fair was defined as up to 50% pain relief with no medication change. A poor outcome was no pain relief.

Rhizotomy resulted in the best possible outcome for a significantly greater percentage of patients who had the procedure for a second time, compared with those who had it for the first time (74% vs. 65%). Good outcomes occurred in 12% of each group. Fair outcomes occurred in 10% of the initial group and 3% of the repeat group, whereas poor outcomes occurred in 13% of the initial group and 10% of the repeat group.

The overall median time to treatment failure was similar between the first-time and repeat treatment groups (27 months vs. 19 months, respectively).

"These outcomes challenge the consensus that repeat glycerol rhizotomy has decreased pain relief and durability," Mr. Bender said. "Not only can this be used as our first-line percutaneous procedure, it can be repeated before resorting to salvage modalities."

Elderly Tolerate Decompression Less. In a third study, Dr. Anand Rughani and his colleagues at the University of Vermont, Burlington, found that elderly patients do not tolerate microvascular decompression nearly as well as younger patients, based on a higher rate of in-hospital complications and mortality in the Nationwide Inpatient Sample.

Over a 10-year period in the database, Dr. Rughani and his associates found 3,273 patients who had undergone the procedure; their median age was 57 years.

The investigators examined in-hospital outcomes in patients younger than age 65 years, those who were 65-74 years old, and those who were 75 years or older.

The risk of any in-hospital complication occurring in a patient over age 65 was 7%, compared with 10% in those over age 75, a significant difference. In-hospital mortality also significantly increased as patients aged: It was 0.13% in those younger than 65 years, 0.68% in those aged 65 years or older, and about 1.5% in those aged 85 years or older.

Other complications occurred with similar frequency in patients 65 years or older and those 75 years or older: Cardiac complications occurred at a rate of 2% in both age groups; pulmonary complications in 2% and 4%, respectively; thromboembolic complications in 1% and 2%; and stroke in 3% and 4%.

"The likelihood of discharge to a nursing home or rehabilitation facility was also robustly associated with age," Dr. Rughani said. "Unfortunately, this review only captures in-hospital complications, so delayed complications like wound infections and pulmonary embolisms might not show up. This analysis could be quite an under-representation of how older patients might respond to microvascular decompression."

None of the authors of the three studies had any financial declarations.