Prostate cancer: Surgery lowers mortality risk in high-risk group

Key clinical point: Radical prostatectomy vs external beam radiotherapy (EBRT) is associated with significant improvement in cancer-specific mortality in patients with National Comprehensive Cancer Network (NCCN) high-risk and Johns Hopkins University (JH) very high-risk prostate cancer.

Major finding: Cancer-specific mortality (CSM) was significantly lower with radical prostatectomy vs EBRT in NCCN high-risk combined group (2.3% vs 4.1%; hazard ratio [HR], 0.68; P < .001) and JH very high-risk subgroup (3.5% vs 6.0%; HR, 0.58; P < .001). There was no significant difference in CSM between 2 treatments in JH high-risk patient subgroup (P = .2).

Study details: Study of 24,407 NCCN high-risk patients with prostate cancer identified from the Surveillance, Epidemiology, and End Results database between 2010 and 2016. Patients were subcategorized into JH high-risk and very high-risk groups.

Disclosures: No funding source was identified for this work. The authors declared no conflict of interests.

Source: Cheirigo F et al. J Urol. 2021 Sep 24. doi: 10.1097/JU.0000000000002250.

Key clinical point: Radical prostatectomy vs external beam radiotherapy (EBRT) is associated with significant improvement in cancer-specific mortality in patients with National Comprehensive Cancer Network (NCCN) high-risk and Johns Hopkins University (JH) very high-risk prostate cancer.

Major finding: Cancer-specific mortality (CSM) was significantly lower with radical prostatectomy vs EBRT in NCCN high-risk combined group (2.3% vs 4.1%; hazard ratio [HR], 0.68; P < .001) and JH very high-risk subgroup (3.5% vs 6.0%; HR, 0.58; P < .001). There was no significant difference in CSM between 2 treatments in JH high-risk patient subgroup (P = .2).

Study details: Study of 24,407 NCCN high-risk patients with prostate cancer identified from the Surveillance, Epidemiology, and End Results database between 2010 and 2016. Patients were subcategorized into JH high-risk and very high-risk groups.

Disclosures: No funding source was identified for this work. The authors declared no conflict of interests.

Source: Cheirigo F et al. J Urol. 2021 Sep 24. doi: 10.1097/JU.0000000000002250.

Key clinical point: Radical prostatectomy vs external beam radiotherapy (EBRT) is associated with significant improvement in cancer-specific mortality in patients with National Comprehensive Cancer Network (NCCN) high-risk and Johns Hopkins University (JH) very high-risk prostate cancer.

Major finding: Cancer-specific mortality (CSM) was significantly lower with radical prostatectomy vs EBRT in NCCN high-risk combined group (2.3% vs 4.1%; hazard ratio [HR], 0.68; P < .001) and JH very high-risk subgroup (3.5% vs 6.0%; HR, 0.58; P < .001). There was no significant difference in CSM between 2 treatments in JH high-risk patient subgroup (P = .2).

Study details: Study of 24,407 NCCN high-risk patients with prostate cancer identified from the Surveillance, Epidemiology, and End Results database between 2010 and 2016. Patients were subcategorized into JH high-risk and very high-risk groups.

Disclosures: No funding source was identified for this work. The authors declared no conflict of interests.

Source: Cheirigo F et al. J Urol. 2021 Sep 24. doi: 10.1097/JU.0000000000002250.