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The female-to-male predominance of primary biliary cholangitis (PBC), formerly cirrhosis, is much lower than previously believed, according to data from Swedish national registers.
Looking at a number of diseases thought to have at least some basis in autoimmunity, researchers found that the relative risk of PBC for women, compared with men, was 4.1, suggesting that, although it remains a disease predominantly affecting women, its prevalence in men might actually be higher than previously thought.
Of the three other gastrointestinal conditions among the 32 autoimmune diseases examined, one showed a female predominance, one showed no difference, and one had a male predominance, reported Dr. Jianguang Ji and his associates at Lund (Sweden) University (J Autoimmune. 2016;69:102-6).
Celiac disease had a slight female predominance, with a relative risk for women of 1.8, compared with men. There was no difference for Crohn’s disease (RR, 1.1), and ulcerative colitis had a slight male predominance (RR, 0.9), the investigators reported.
The situation was similar for the larger group of conditions: Eighteen showed a female predominance, 7 had no difference, and 7 showed a male predominance, they noted.
“Most review papers claim that the vast majority of autoimmune diseases have a striking female predominance, and most of them cited that more than 80% of cases affected are women. In this population-based study of 32 specific autoimmune diseases with more than 20 years of follow-up, we found that the incidence in women was only 60% higher as compared to that in men,” Dr. Ji and his associates wrote.
The investigators searched the Swedish Hospital Discharge Register and the Swedish Outpatient Register and found data on 403,757 individuals who had been diagnosed with one or more of the 32 autoimmune diseases between 1987 and 2010. About 62% of the subjects were female.
Dr. Ji and his associates had no conflicts of interest to report. The study was supported by the Swedish Research Council and Region Skåne.
The female-to-male predominance of primary biliary cholangitis (PBC), formerly cirrhosis, is much lower than previously believed, according to data from Swedish national registers.
Looking at a number of diseases thought to have at least some basis in autoimmunity, researchers found that the relative risk of PBC for women, compared with men, was 4.1, suggesting that, although it remains a disease predominantly affecting women, its prevalence in men might actually be higher than previously thought.
Of the three other gastrointestinal conditions among the 32 autoimmune diseases examined, one showed a female predominance, one showed no difference, and one had a male predominance, reported Dr. Jianguang Ji and his associates at Lund (Sweden) University (J Autoimmune. 2016;69:102-6).
Celiac disease had a slight female predominance, with a relative risk for women of 1.8, compared with men. There was no difference for Crohn’s disease (RR, 1.1), and ulcerative colitis had a slight male predominance (RR, 0.9), the investigators reported.
The situation was similar for the larger group of conditions: Eighteen showed a female predominance, 7 had no difference, and 7 showed a male predominance, they noted.
“Most review papers claim that the vast majority of autoimmune diseases have a striking female predominance, and most of them cited that more than 80% of cases affected are women. In this population-based study of 32 specific autoimmune diseases with more than 20 years of follow-up, we found that the incidence in women was only 60% higher as compared to that in men,” Dr. Ji and his associates wrote.
The investigators searched the Swedish Hospital Discharge Register and the Swedish Outpatient Register and found data on 403,757 individuals who had been diagnosed with one or more of the 32 autoimmune diseases between 1987 and 2010. About 62% of the subjects were female.
Dr. Ji and his associates had no conflicts of interest to report. The study was supported by the Swedish Research Council and Region Skåne.
The female-to-male predominance of primary biliary cholangitis (PBC), formerly cirrhosis, is much lower than previously believed, according to data from Swedish national registers.
Looking at a number of diseases thought to have at least some basis in autoimmunity, researchers found that the relative risk of PBC for women, compared with men, was 4.1, suggesting that, although it remains a disease predominantly affecting women, its prevalence in men might actually be higher than previously thought.
Of the three other gastrointestinal conditions among the 32 autoimmune diseases examined, one showed a female predominance, one showed no difference, and one had a male predominance, reported Dr. Jianguang Ji and his associates at Lund (Sweden) University (J Autoimmune. 2016;69:102-6).
Celiac disease had a slight female predominance, with a relative risk for women of 1.8, compared with men. There was no difference for Crohn’s disease (RR, 1.1), and ulcerative colitis had a slight male predominance (RR, 0.9), the investigators reported.
The situation was similar for the larger group of conditions: Eighteen showed a female predominance, 7 had no difference, and 7 showed a male predominance, they noted.
“Most review papers claim that the vast majority of autoimmune diseases have a striking female predominance, and most of them cited that more than 80% of cases affected are women. In this population-based study of 32 specific autoimmune diseases with more than 20 years of follow-up, we found that the incidence in women was only 60% higher as compared to that in men,” Dr. Ji and his associates wrote.
The investigators searched the Swedish Hospital Discharge Register and the Swedish Outpatient Register and found data on 403,757 individuals who had been diagnosed with one or more of the 32 autoimmune diseases between 1987 and 2010. About 62% of the subjects were female.
Dr. Ji and his associates had no conflicts of interest to report. The study was supported by the Swedish Research Council and Region Skåne.
FROM THE JOURNAL OF AUTOIMMUNITY
