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Patients with septic shock had similar outcomes when transfused at hemoglobin thresholds of 7 g/dL as compared with 9 g/dL, investigators reported online Oct. 1 in the New England Journal of Medicine.
Mortality at 90 days, use of life support, number of days alive and out of the hospital, number of ischemic events, and severe adverse reactions to blood in the intensive care unit (ICU) all were similar between the two groups, said Dr. Lars B. Holst at Rigshospitalet and the University of Copenhagen and his associates. At the same time, patients treated at the lower threshold received three times as many units of blood as did those treated at the higher threshold (median of 4 units and 1 unit, respectively), the researchers reported.
For the multicenter Transfusion Requirements in Septic Shock (TRISS) trial, the investigators randomized 998 ICU patients with septic shock to receive 1 unit of leukoreduced red cells when their hemoglobin level was either 9 g/dL or less (higher threshold) or 7 g/dL or less (lower threshold). Ninety days later, 43% of patients in the 7-g/dL threshold group had died, compared with 45% of the higher-threshold group, a nonsignificant difference, the investigators said. Controlling for baseline risk factors did not affect the finding, they reported (N. Engl. J. Med. 2014 Oct. 1 [doi: 10.1056/NEJMoa1406617]).
Rates of ischemic events and the need for life support also did not differ significantly between the two groups, Dr. Holst and his associates reported.
The study was funded by the Copenhagen University Hospital, Rigshospitalet, and several Scandinavian research foundations. Two coauthors reported financial relationships with Pharmacosmos, CSL Behring, and other companies. The other authors reported no conflicts of interest.
Holst and colleagues provide definitive evidence that a restrictive approach to blood transfusion not only reduced blood use by half but also did not cause harm to critically ill patients with septic shock.
We believe it has become abundantly clear that a transfusion threshold of 7 g/dL should become the new normal, recommended in all critically ill patients, including those with severe sepsis and septic shock. To speed up adoption, we should ensure that clinical practice guidelines are rapidly updated with new information. Indeed, most transfusion guidelines have already been updated, but this is not so for sepsis guidelines.
Evidence stills remains weak in patients with an acute coronary syndrome. It may yet be proved that this distinct group of patients benefits from higher hemoglobin concentrations of 9 or 10 g/dL. Oxygen delivery to the myocardium is flow dependent since the heart extracts a high percentage of oxygen, and myocardial ischemia may be precipitated by low hemoglobin concentrations.
Paul C. Hébert, M.D., is at the Montreal University Health Center. Jeffrey L. Carson, M.D., is at the Robert Wood Johnson Medical School in New Brunswick, New Jersey. These remarks were taken from their editorial accompanying Dr. Holst’s report (N. Engl. J. Med. 2014 Oct. 1 [doi: 10.1056/NEJMe1408976]).
Holst and colleagues provide definitive evidence that a restrictive approach to blood transfusion not only reduced blood use by half but also did not cause harm to critically ill patients with septic shock.
We believe it has become abundantly clear that a transfusion threshold of 7 g/dL should become the new normal, recommended in all critically ill patients, including those with severe sepsis and septic shock. To speed up adoption, we should ensure that clinical practice guidelines are rapidly updated with new information. Indeed, most transfusion guidelines have already been updated, but this is not so for sepsis guidelines.
Evidence stills remains weak in patients with an acute coronary syndrome. It may yet be proved that this distinct group of patients benefits from higher hemoglobin concentrations of 9 or 10 g/dL. Oxygen delivery to the myocardium is flow dependent since the heart extracts a high percentage of oxygen, and myocardial ischemia may be precipitated by low hemoglobin concentrations.
Paul C. Hébert, M.D., is at the Montreal University Health Center. Jeffrey L. Carson, M.D., is at the Robert Wood Johnson Medical School in New Brunswick, New Jersey. These remarks were taken from their editorial accompanying Dr. Holst’s report (N. Engl. J. Med. 2014 Oct. 1 [doi: 10.1056/NEJMe1408976]).
Holst and colleagues provide definitive evidence that a restrictive approach to blood transfusion not only reduced blood use by half but also did not cause harm to critically ill patients with septic shock.
We believe it has become abundantly clear that a transfusion threshold of 7 g/dL should become the new normal, recommended in all critically ill patients, including those with severe sepsis and septic shock. To speed up adoption, we should ensure that clinical practice guidelines are rapidly updated with new information. Indeed, most transfusion guidelines have already been updated, but this is not so for sepsis guidelines.
Evidence stills remains weak in patients with an acute coronary syndrome. It may yet be proved that this distinct group of patients benefits from higher hemoglobin concentrations of 9 or 10 g/dL. Oxygen delivery to the myocardium is flow dependent since the heart extracts a high percentage of oxygen, and myocardial ischemia may be precipitated by low hemoglobin concentrations.
Paul C. Hébert, M.D., is at the Montreal University Health Center. Jeffrey L. Carson, M.D., is at the Robert Wood Johnson Medical School in New Brunswick, New Jersey. These remarks were taken from their editorial accompanying Dr. Holst’s report (N. Engl. J. Med. 2014 Oct. 1 [doi: 10.1056/NEJMe1408976]).
Patients with septic shock had similar outcomes when transfused at hemoglobin thresholds of 7 g/dL as compared with 9 g/dL, investigators reported online Oct. 1 in the New England Journal of Medicine.
Mortality at 90 days, use of life support, number of days alive and out of the hospital, number of ischemic events, and severe adverse reactions to blood in the intensive care unit (ICU) all were similar between the two groups, said Dr. Lars B. Holst at Rigshospitalet and the University of Copenhagen and his associates. At the same time, patients treated at the lower threshold received three times as many units of blood as did those treated at the higher threshold (median of 4 units and 1 unit, respectively), the researchers reported.
For the multicenter Transfusion Requirements in Septic Shock (TRISS) trial, the investigators randomized 998 ICU patients with septic shock to receive 1 unit of leukoreduced red cells when their hemoglobin level was either 9 g/dL or less (higher threshold) or 7 g/dL or less (lower threshold). Ninety days later, 43% of patients in the 7-g/dL threshold group had died, compared with 45% of the higher-threshold group, a nonsignificant difference, the investigators said. Controlling for baseline risk factors did not affect the finding, they reported (N. Engl. J. Med. 2014 Oct. 1 [doi: 10.1056/NEJMoa1406617]).
Rates of ischemic events and the need for life support also did not differ significantly between the two groups, Dr. Holst and his associates reported.
The study was funded by the Copenhagen University Hospital, Rigshospitalet, and several Scandinavian research foundations. Two coauthors reported financial relationships with Pharmacosmos, CSL Behring, and other companies. The other authors reported no conflicts of interest.
Patients with septic shock had similar outcomes when transfused at hemoglobin thresholds of 7 g/dL as compared with 9 g/dL, investigators reported online Oct. 1 in the New England Journal of Medicine.
Mortality at 90 days, use of life support, number of days alive and out of the hospital, number of ischemic events, and severe adverse reactions to blood in the intensive care unit (ICU) all were similar between the two groups, said Dr. Lars B. Holst at Rigshospitalet and the University of Copenhagen and his associates. At the same time, patients treated at the lower threshold received three times as many units of blood as did those treated at the higher threshold (median of 4 units and 1 unit, respectively), the researchers reported.
For the multicenter Transfusion Requirements in Septic Shock (TRISS) trial, the investigators randomized 998 ICU patients with septic shock to receive 1 unit of leukoreduced red cells when their hemoglobin level was either 9 g/dL or less (higher threshold) or 7 g/dL or less (lower threshold). Ninety days later, 43% of patients in the 7-g/dL threshold group had died, compared with 45% of the higher-threshold group, a nonsignificant difference, the investigators said. Controlling for baseline risk factors did not affect the finding, they reported (N. Engl. J. Med. 2014 Oct. 1 [doi: 10.1056/NEJMoa1406617]).
Rates of ischemic events and the need for life support also did not differ significantly between the two groups, Dr. Holst and his associates reported.
The study was funded by the Copenhagen University Hospital, Rigshospitalet, and several Scandinavian research foundations. Two coauthors reported financial relationships with Pharmacosmos, CSL Behring, and other companies. The other authors reported no conflicts of interest.