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Key clinical point: Patients with an acute flare of inflammatory bowel disease (IBD) treated with intravenous methylprednisolone (IVMP) required significantly more rescue biologics or cyclosporine. Additionally, IVMP significantly reduced rates of hypokalemia compared with intravenous hydrocortisone (IVHC).
Major finding: IVMP was associated with a greater requirement for rescue biologics or cyclosporine (odds ratio [OR], 2.79; P less than .001) and lower rates of hypokalemia (OR, 0.49; P = .005) than IVHC.
Study details: This was a multicenter cohort study of 359 patients hospitalized with an acute flare of IBD and treated with either IVMP 60 mg daily (n=129) or IVHC 100 mg 4 times daily (n=230).
Disclosures: The study did not receive any funding. All the authors declared no conflicts of interest.
Source: Schauer C et al. J Gastroenterol Hepatol. 2021 May 3. doi: 10.1111/jgh.15535.
Key clinical point: Patients with an acute flare of inflammatory bowel disease (IBD) treated with intravenous methylprednisolone (IVMP) required significantly more rescue biologics or cyclosporine. Additionally, IVMP significantly reduced rates of hypokalemia compared with intravenous hydrocortisone (IVHC).
Major finding: IVMP was associated with a greater requirement for rescue biologics or cyclosporine (odds ratio [OR], 2.79; P less than .001) and lower rates of hypokalemia (OR, 0.49; P = .005) than IVHC.
Study details: This was a multicenter cohort study of 359 patients hospitalized with an acute flare of IBD and treated with either IVMP 60 mg daily (n=129) or IVHC 100 mg 4 times daily (n=230).
Disclosures: The study did not receive any funding. All the authors declared no conflicts of interest.
Source: Schauer C et al. J Gastroenterol Hepatol. 2021 May 3. doi: 10.1111/jgh.15535.
Key clinical point: Patients with an acute flare of inflammatory bowel disease (IBD) treated with intravenous methylprednisolone (IVMP) required significantly more rescue biologics or cyclosporine. Additionally, IVMP significantly reduced rates of hypokalemia compared with intravenous hydrocortisone (IVHC).
Major finding: IVMP was associated with a greater requirement for rescue biologics or cyclosporine (odds ratio [OR], 2.79; P less than .001) and lower rates of hypokalemia (OR, 0.49; P = .005) than IVHC.
Study details: This was a multicenter cohort study of 359 patients hospitalized with an acute flare of IBD and treated with either IVMP 60 mg daily (n=129) or IVHC 100 mg 4 times daily (n=230).
Disclosures: The study did not receive any funding. All the authors declared no conflicts of interest.
Source: Schauer C et al. J Gastroenterol Hepatol. 2021 May 3. doi: 10.1111/jgh.15535.