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Key clinical point: A prognostic model based on immune-related genes showed promise as a predictor of overall survival in hepatocellular carcinoma patients; 7 genes were better prognosticators than the tumor/node/metastasis (TNM) staging system.
Major finding: Clinical outcomes in HCC patients were associated with 100 immune-related differentially-expressed genes (DEGs). The researchers identified 7 prognostic immune-related genes (IRGs) after combining data types from multiple databases: Fatty Acid Binding Protein 6 (FABP6), Microtubule-Associated Protein Tau (MAPT), Baculoviral IAP Repeat Containing 5 (BIRC5), Plexin-A1 (PLXNA1), Secreted Phosphoprotein 1 (SPP1), Stanniocalcin 2 (STC2) and Chondroitin Sulfate Proteoglycan 5 (CSPG5).
Study details: The data come from 424 adults with hepatocellular carcinoma; the researchers integrated RNA sequencing profiles from the patients with immune-related genes to calculate immune-related differentially-expressed genes.
Disclosures: The study was supported in part by Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine National University Student Innovation and Entrepreneurship Training Project, and the First Affiliated Hospital of Guangzhou University of Chinese Medicine Innovation and Student Training Team Incubation Project. The researchers had no financial conflicts to disclose.
Source: Yan Q et al. BioData Min. 2021 May 7. doi: 0.1186/s13040-021-00261-y.
Key clinical point: A prognostic model based on immune-related genes showed promise as a predictor of overall survival in hepatocellular carcinoma patients; 7 genes were better prognosticators than the tumor/node/metastasis (TNM) staging system.
Major finding: Clinical outcomes in HCC patients were associated with 100 immune-related differentially-expressed genes (DEGs). The researchers identified 7 prognostic immune-related genes (IRGs) after combining data types from multiple databases: Fatty Acid Binding Protein 6 (FABP6), Microtubule-Associated Protein Tau (MAPT), Baculoviral IAP Repeat Containing 5 (BIRC5), Plexin-A1 (PLXNA1), Secreted Phosphoprotein 1 (SPP1), Stanniocalcin 2 (STC2) and Chondroitin Sulfate Proteoglycan 5 (CSPG5).
Study details: The data come from 424 adults with hepatocellular carcinoma; the researchers integrated RNA sequencing profiles from the patients with immune-related genes to calculate immune-related differentially-expressed genes.
Disclosures: The study was supported in part by Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine National University Student Innovation and Entrepreneurship Training Project, and the First Affiliated Hospital of Guangzhou University of Chinese Medicine Innovation and Student Training Team Incubation Project. The researchers had no financial conflicts to disclose.
Source: Yan Q et al. BioData Min. 2021 May 7. doi: 0.1186/s13040-021-00261-y.
Key clinical point: A prognostic model based on immune-related genes showed promise as a predictor of overall survival in hepatocellular carcinoma patients; 7 genes were better prognosticators than the tumor/node/metastasis (TNM) staging system.
Major finding: Clinical outcomes in HCC patients were associated with 100 immune-related differentially-expressed genes (DEGs). The researchers identified 7 prognostic immune-related genes (IRGs) after combining data types from multiple databases: Fatty Acid Binding Protein 6 (FABP6), Microtubule-Associated Protein Tau (MAPT), Baculoviral IAP Repeat Containing 5 (BIRC5), Plexin-A1 (PLXNA1), Secreted Phosphoprotein 1 (SPP1), Stanniocalcin 2 (STC2) and Chondroitin Sulfate Proteoglycan 5 (CSPG5).
Study details: The data come from 424 adults with hepatocellular carcinoma; the researchers integrated RNA sequencing profiles from the patients with immune-related genes to calculate immune-related differentially-expressed genes.
Disclosures: The study was supported in part by Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine National University Student Innovation and Entrepreneurship Training Project, and the First Affiliated Hospital of Guangzhou University of Chinese Medicine Innovation and Student Training Team Incubation Project. The researchers had no financial conflicts to disclose.
Source: Yan Q et al. BioData Min. 2021 May 7. doi: 0.1186/s13040-021-00261-y.