How is migraine associated with cardiovascular and cerebrovascular events?

Key clinical point: Patients with migraine are at an increased risk of myocardial infarction (MI) and stroke, and those with migraine with aura are also at an increased risk of overall cardiovascular mortality.

Main finding: Migraine showed a positive association with MI (hazard ratio [HR] 1.36; P < .001), unspecified stroke (HR 1.30; P = .01), ischemic stroke (HR 1.35; P = .03), and hemorrhagic stroke (HR 1.43; P = .02). Migraine with aura was positively associated with cardiovascular mortality (HR 1.27; P < .001).

Study details: Findings are from a meta-analysis of 18 prospective cohort studies including 362,434 patients with migraine and 1,323,714 control participants.

Disclosures: BYQ Tan declared receiving the Ministry of Health Healthcare Research Scholarship, Singapore, and the Chan Heng Leong Research Award. CH Sia received financial support from the National University of Singapore Yong Loo Lin School of Medicine’s Junior Academic Faculty Scheme. The authors declared no competing interests.

Source: Ng CYH et al. J Neurol. 2022 (Jan 8). Doi: 10.1007/s00415-021-10930-x.

Key clinical point: Patients with migraine are at an increased risk of myocardial infarction (MI) and stroke, and those with migraine with aura are also at an increased risk of overall cardiovascular mortality.

Main finding: Migraine showed a positive association with MI (hazard ratio [HR] 1.36; P < .001), unspecified stroke (HR 1.30; P = .01), ischemic stroke (HR 1.35; P = .03), and hemorrhagic stroke (HR 1.43; P = .02). Migraine with aura was positively associated with cardiovascular mortality (HR 1.27; P < .001).

Study details: Findings are from a meta-analysis of 18 prospective cohort studies including 362,434 patients with migraine and 1,323,714 control participants.

Disclosures: BYQ Tan declared receiving the Ministry of Health Healthcare Research Scholarship, Singapore, and the Chan Heng Leong Research Award. CH Sia received financial support from the National University of Singapore Yong Loo Lin School of Medicine’s Junior Academic Faculty Scheme. The authors declared no competing interests.

Source: Ng CYH et al. J Neurol. 2022 (Jan 8). Doi: 10.1007/s00415-021-10930-x.

Key clinical point: Patients with migraine are at an increased risk of myocardial infarction (MI) and stroke, and those with migraine with aura are also at an increased risk of overall cardiovascular mortality.

Main finding: Migraine showed a positive association with MI (hazard ratio [HR] 1.36; P < .001), unspecified stroke (HR 1.30; P = .01), ischemic stroke (HR 1.35; P = .03), and hemorrhagic stroke (HR 1.43; P = .02). Migraine with aura was positively associated with cardiovascular mortality (HR 1.27; P < .001).

Study details: Findings are from a meta-analysis of 18 prospective cohort studies including 362,434 patients with migraine and 1,323,714 control participants.

Disclosures: BYQ Tan declared receiving the Ministry of Health Healthcare Research Scholarship, Singapore, and the Chan Heng Leong Research Award. CH Sia received financial support from the National University of Singapore Yong Loo Lin School of Medicine’s Junior Academic Faculty Scheme. The authors declared no competing interests.

Source: Ng CYH et al. J Neurol. 2022 (Jan 8). Doi: 10.1007/s00415-021-10930-x.