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who have end-stage renal disease, according to a study published in Kidney International.
Nonwhites fared significantly worse in survival than did the white cohort when both groups were infected with HIV alone, but the two groups fared similarly badly when coinfected with HIV and HCV, according to Deirdre L. Sawinski, MD, assistant professor at the University of Pennsylvania, Philadelphia, and assistant medical director, Penn Kidney Pancreas Transplant Program, and her colleagues.
They found that HIV infection was not associated with a higher risk of death in white patients (hazard ratio, 1.03), in contrast to HIV/HCV coinfection, which was significantly associated with a higher mortality (HR, 1.48). However, in the nonwhite patients, HIV infection (HR, 1.44) and HIV/HCV coinfection (HR, 1.71) were both significantly associated with increased mortality.
“HIV infection remains associated with inferior dialysis survival for [nonwhites], even in the contemporary era and with widespread ART use,” Dr. Sawinski and her colleagues summarized. “Although the underlying mechanisms of these racial disparities require further elucidation, bias within the health care system could contribute to worse outcomes for [nonwhite] individuals who have HIV, and dialysis providers should work to eliminate disparities in care wherever they are identified.”
They recommended early nephrology referral for transition to renal replacement therapy and care coordination with infectious disease and hepatology specialists, including evaluation for home dialysis, to improve the chances of survival in these patients. Given the added risk of death in coinfected individuals, they also suggested that therapy for HCV may be beneficial.
One author consulted on a project related to hyperkalemia and hyperphosphatemia in dialysis patients and has grant funding from Merck on treating hepatitis C infection after kidney transplantation. The other authors had no disclosures.
who have end-stage renal disease, according to a study published in Kidney International.
Nonwhites fared significantly worse in survival than did the white cohort when both groups were infected with HIV alone, but the two groups fared similarly badly when coinfected with HIV and HCV, according to Deirdre L. Sawinski, MD, assistant professor at the University of Pennsylvania, Philadelphia, and assistant medical director, Penn Kidney Pancreas Transplant Program, and her colleagues.
They found that HIV infection was not associated with a higher risk of death in white patients (hazard ratio, 1.03), in contrast to HIV/HCV coinfection, which was significantly associated with a higher mortality (HR, 1.48). However, in the nonwhite patients, HIV infection (HR, 1.44) and HIV/HCV coinfection (HR, 1.71) were both significantly associated with increased mortality.
“HIV infection remains associated with inferior dialysis survival for [nonwhites], even in the contemporary era and with widespread ART use,” Dr. Sawinski and her colleagues summarized. “Although the underlying mechanisms of these racial disparities require further elucidation, bias within the health care system could contribute to worse outcomes for [nonwhite] individuals who have HIV, and dialysis providers should work to eliminate disparities in care wherever they are identified.”
They recommended early nephrology referral for transition to renal replacement therapy and care coordination with infectious disease and hepatology specialists, including evaluation for home dialysis, to improve the chances of survival in these patients. Given the added risk of death in coinfected individuals, they also suggested that therapy for HCV may be beneficial.
One author consulted on a project related to hyperkalemia and hyperphosphatemia in dialysis patients and has grant funding from Merck on treating hepatitis C infection after kidney transplantation. The other authors had no disclosures.
who have end-stage renal disease, according to a study published in Kidney International.
Nonwhites fared significantly worse in survival than did the white cohort when both groups were infected with HIV alone, but the two groups fared similarly badly when coinfected with HIV and HCV, according to Deirdre L. Sawinski, MD, assistant professor at the University of Pennsylvania, Philadelphia, and assistant medical director, Penn Kidney Pancreas Transplant Program, and her colleagues.
They found that HIV infection was not associated with a higher risk of death in white patients (hazard ratio, 1.03), in contrast to HIV/HCV coinfection, which was significantly associated with a higher mortality (HR, 1.48). However, in the nonwhite patients, HIV infection (HR, 1.44) and HIV/HCV coinfection (HR, 1.71) were both significantly associated with increased mortality.
“HIV infection remains associated with inferior dialysis survival for [nonwhites], even in the contemporary era and with widespread ART use,” Dr. Sawinski and her colleagues summarized. “Although the underlying mechanisms of these racial disparities require further elucidation, bias within the health care system could contribute to worse outcomes for [nonwhite] individuals who have HIV, and dialysis providers should work to eliminate disparities in care wherever they are identified.”
They recommended early nephrology referral for transition to renal replacement therapy and care coordination with infectious disease and hepatology specialists, including evaluation for home dialysis, to improve the chances of survival in these patients. Given the added risk of death in coinfected individuals, they also suggested that therapy for HCV may be beneficial.
One author consulted on a project related to hyperkalemia and hyperphosphatemia in dialysis patients and has grant funding from Merck on treating hepatitis C infection after kidney transplantation. The other authors had no disclosures.
FROM KIDNEY INTERNATIONAL
Key clinical point: Race is significantly associated with mortality in HIV-infected dialysis patients.
Major finding: HIV infection is associated with a significant reduction in dialysis survival for nonwhites; HIV/HCV coinfection is associated with impaired survival regardless of race/ethnicity.
Study details: Survival on dialysis of 5,348 HIV-infected individuals and 1,863 HIV/HCV coinfected individuals was retrospectively compared with an HIV/HCV reference cohort.
Disclosures: One author consulted on a project related to hyperkalemia and hyperphosphatemia in dialysis patients, and has grant funding from Merck in support of treating hepatitis C after kidney transplantation. The other authors had no disclosures.
Source: Sawinski et al. Kidney Int. 2018;93(3):706-15.