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Key clinical point: Higher vitamin D intake was associated with a lower risk for early-onset colorectal cancer (CRC) in younger women. The risk reduction was mainly driven by dietary vitamin D.
Major finding: The risk for CRC was significantly lower in women younger than 50 years of age with 450 or higher IU/day (hazard ratio [HR], 0.49) or 300 to less than 450 IU/day (HR, 0.51) vsvs less than 300 IU/day (P for trend = .01) of total vitamin D intake. The risk reduction was significant and stronger for dietary vsvs supplemental vitamin D (HR per 400 IU/day increase, 0.34; 95% confidence interval, 0.15-0.79).
Study details: Findings are from a prospective cohort study of 94,205 female nurses aged 25-42 years from the Nurses’ Health Study II.
Disclosures: The study was supported by grants from the National Institutes of Health, Department of Defense, American Cancer Society Mentored Research Scholar, and Project P Fund. AT Chan, C Fuchs, and K Ng reported receiving consulting fees, research funding, and/or serving as a consultant and/or a scientific advisor for various sources.
Source: Kim H et al. Gastroenterology. 2021 Jul 6. doi: 10.1053/j.gastro.2021.07.002.
Key clinical point: Higher vitamin D intake was associated with a lower risk for early-onset colorectal cancer (CRC) in younger women. The risk reduction was mainly driven by dietary vitamin D.
Major finding: The risk for CRC was significantly lower in women younger than 50 years of age with 450 or higher IU/day (hazard ratio [HR], 0.49) or 300 to less than 450 IU/day (HR, 0.51) vsvs less than 300 IU/day (P for trend = .01) of total vitamin D intake. The risk reduction was significant and stronger for dietary vsvs supplemental vitamin D (HR per 400 IU/day increase, 0.34; 95% confidence interval, 0.15-0.79).
Study details: Findings are from a prospective cohort study of 94,205 female nurses aged 25-42 years from the Nurses’ Health Study II.
Disclosures: The study was supported by grants from the National Institutes of Health, Department of Defense, American Cancer Society Mentored Research Scholar, and Project P Fund. AT Chan, C Fuchs, and K Ng reported receiving consulting fees, research funding, and/or serving as a consultant and/or a scientific advisor for various sources.
Source: Kim H et al. Gastroenterology. 2021 Jul 6. doi: 10.1053/j.gastro.2021.07.002.
Key clinical point: Higher vitamin D intake was associated with a lower risk for early-onset colorectal cancer (CRC) in younger women. The risk reduction was mainly driven by dietary vitamin D.
Major finding: The risk for CRC was significantly lower in women younger than 50 years of age with 450 or higher IU/day (hazard ratio [HR], 0.49) or 300 to less than 450 IU/day (HR, 0.51) vsvs less than 300 IU/day (P for trend = .01) of total vitamin D intake. The risk reduction was significant and stronger for dietary vsvs supplemental vitamin D (HR per 400 IU/day increase, 0.34; 95% confidence interval, 0.15-0.79).
Study details: Findings are from a prospective cohort study of 94,205 female nurses aged 25-42 years from the Nurses’ Health Study II.
Disclosures: The study was supported by grants from the National Institutes of Health, Department of Defense, American Cancer Society Mentored Research Scholar, and Project P Fund. AT Chan, C Fuchs, and K Ng reported receiving consulting fees, research funding, and/or serving as a consultant and/or a scientific advisor for various sources.
Source: Kim H et al. Gastroenterology. 2021 Jul 6. doi: 10.1053/j.gastro.2021.07.002.