FPG measurements could help identify individuals at higher risk for future CRC

Key clinical point: The risk for incident colorectal cancer (CRC) events increases with the presence of normal-high fasting plasma glucose (FPG), impaired fasting glucose (IFG), and diabetes mellitus (DM).

Major finding: Compared with normal FPG, the presence of normal-high FPG (hazard ratio [HR], 1.10; 95% confidence interval [CI], 1.03-1.18), IFG (HR, 1.24; 95% CI, 1.13-1.37), and DM (HR, 1.36; 95% CI, 1.19-1.55) was associated with a higher incidence rate of CRC.

Study details: Findings are from a retrospective observational study of 1,441,311 individuals who underwent annual health checkups. Included patients did not have colorectal polyps, Crohn's disease, and/or ulcerative colitis and were not taking antidiabetic medications.

Disclosures: The study was supported by grants from the Ministry of Health, Labour, and Welfare and the Ministry of Education, Culture, Sports, Science, and Technology, Japan. H Kaneko and K Fujiu declared receiving research funding and scholarship funds from various sources.

Source: Itoh H et al. J Clin Endocrinol Metab. 2021 Jun 25. doi: 10.1210/clinem/dgab466.

Key clinical point: The risk for incident colorectal cancer (CRC) events increases with the presence of normal-high fasting plasma glucose (FPG), impaired fasting glucose (IFG), and diabetes mellitus (DM).

Major finding: Compared with normal FPG, the presence of normal-high FPG (hazard ratio [HR], 1.10; 95% confidence interval [CI], 1.03-1.18), IFG (HR, 1.24; 95% CI, 1.13-1.37), and DM (HR, 1.36; 95% CI, 1.19-1.55) was associated with a higher incidence rate of CRC.

Study details: Findings are from a retrospective observational study of 1,441,311 individuals who underwent annual health checkups. Included patients did not have colorectal polyps, Crohn's disease, and/or ulcerative colitis and were not taking antidiabetic medications.

Disclosures: The study was supported by grants from the Ministry of Health, Labour, and Welfare and the Ministry of Education, Culture, Sports, Science, and Technology, Japan. H Kaneko and K Fujiu declared receiving research funding and scholarship funds from various sources.

Source: Itoh H et al. J Clin Endocrinol Metab. 2021 Jun 25. doi: 10.1210/clinem/dgab466.

Key clinical point: The risk for incident colorectal cancer (CRC) events increases with the presence of normal-high fasting plasma glucose (FPG), impaired fasting glucose (IFG), and diabetes mellitus (DM).

Major finding: Compared with normal FPG, the presence of normal-high FPG (hazard ratio [HR], 1.10; 95% confidence interval [CI], 1.03-1.18), IFG (HR, 1.24; 95% CI, 1.13-1.37), and DM (HR, 1.36; 95% CI, 1.19-1.55) was associated with a higher incidence rate of CRC.

Study details: Findings are from a retrospective observational study of 1,441,311 individuals who underwent annual health checkups. Included patients did not have colorectal polyps, Crohn's disease, and/or ulcerative colitis and were not taking antidiabetic medications.

Disclosures: The study was supported by grants from the Ministry of Health, Labour, and Welfare and the Ministry of Education, Culture, Sports, Science, and Technology, Japan. H Kaneko and K Fujiu declared receiving research funding and scholarship funds from various sources.

Source: Itoh H et al. J Clin Endocrinol Metab. 2021 Jun 25. doi: 10.1210/clinem/dgab466.