Family history of prostate or breast cancer is linked with high-grade prostate cancer

Key clinical point: Men with a first- or second-degree family history of prostate cancer and a first-degree family history of breast cancer show increased risk for high-grade prostate cancer at biopsy.

Major finding: The risk for high-grade prostate cancer on biopsy increased in men with a first-degree family history (adjusted odds ratio [aOR], 1.77; P < .001) and a second-degree family history of the disease (aOR, 1.38; P = .011). A first-degree relative with breast cancer was associated with high-grade prostate cancer on biopsy (aOR, 1.30; P = .040).

Study details: A multicenter study of 15,799 men who underwent prostate biopsy between 2006 and 2019.

Disclosures: This work was supported by Research and Development Service, Urology Section, Surgery Department, and Department of Veterans Affairs, Caribbean Healthcare System San Juan, PR, USA. The authors disclosed being coinventor/employed, holding stocks, or received royalty.

Source: Clements MB et al. Eur Urol. 2021 Dec 31. doi: 10.1016/j.eururo.2021.12.011.

Key clinical point: Men with a first- or second-degree family history of prostate cancer and a first-degree family history of breast cancer show increased risk for high-grade prostate cancer at biopsy.

Major finding: The risk for high-grade prostate cancer on biopsy increased in men with a first-degree family history (adjusted odds ratio [aOR], 1.77; P < .001) and a second-degree family history of the disease (aOR, 1.38; P = .011). A first-degree relative with breast cancer was associated with high-grade prostate cancer on biopsy (aOR, 1.30; P = .040).

Study details: A multicenter study of 15,799 men who underwent prostate biopsy between 2006 and 2019.

Disclosures: This work was supported by Research and Development Service, Urology Section, Surgery Department, and Department of Veterans Affairs, Caribbean Healthcare System San Juan, PR, USA. The authors disclosed being coinventor/employed, holding stocks, or received royalty.

Source: Clements MB et al. Eur Urol. 2021 Dec 31. doi: 10.1016/j.eururo.2021.12.011.

Key clinical point: Men with a first- or second-degree family history of prostate cancer and a first-degree family history of breast cancer show increased risk for high-grade prostate cancer at biopsy.

Major finding: The risk for high-grade prostate cancer on biopsy increased in men with a first-degree family history (adjusted odds ratio [aOR], 1.77; P < .001) and a second-degree family history of the disease (aOR, 1.38; P = .011). A first-degree relative with breast cancer was associated with high-grade prostate cancer on biopsy (aOR, 1.30; P = .040).

Study details: A multicenter study of 15,799 men who underwent prostate biopsy between 2006 and 2019.

Disclosures: This work was supported by Research and Development Service, Urology Section, Surgery Department, and Department of Veterans Affairs, Caribbean Healthcare System San Juan, PR, USA. The authors disclosed being coinventor/employed, holding stocks, or received royalty.

Source: Clements MB et al. Eur Urol. 2021 Dec 31. doi: 10.1016/j.eururo.2021.12.011.