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Key clinical point: This meta-analysis demonstrated that the elevated pretreatment neutrophil-to-lymphocyte ratio (NLR) was correlated with poor long-term survival in patients with colorectal cancer (CRC) liver metastasis, including those who underwent surgery.
Major finding: Higher NLR was associated with poor overall survival (OS; hazard ratio [HR] 1.95; P < .01) and disease-free survival (DFS; HR 1.80; P < .01), and normal vs elevated NLR was associated with a better OS among patients who underwent surgery (HR 1.95; P < .01). The 5-year OS and DFS rates were higher in patients with normal vs high NLR (both P < .01).
Study details: The data come from a meta-analysis of 14 retrospective studies including 2974 participants.
Disclosures: This study was supported by the Startup Fund for Scientific Research, Fujian Medical University, China. No conflicts of interest were declared.
Source: Lin N et al. Prognostic value of neutrophil-to-lymphocyte ratio in colorectal cancer liver metastasis: A meta-analysis of results from multivariate analysis. Int J Surg. 2022;107:106959 (Oct 17). Doi: 10.1016/j.ijsu.2022.106959
Key clinical point: This meta-analysis demonstrated that the elevated pretreatment neutrophil-to-lymphocyte ratio (NLR) was correlated with poor long-term survival in patients with colorectal cancer (CRC) liver metastasis, including those who underwent surgery.
Major finding: Higher NLR was associated with poor overall survival (OS; hazard ratio [HR] 1.95; P < .01) and disease-free survival (DFS; HR 1.80; P < .01), and normal vs elevated NLR was associated with a better OS among patients who underwent surgery (HR 1.95; P < .01). The 5-year OS and DFS rates were higher in patients with normal vs high NLR (both P < .01).
Study details: The data come from a meta-analysis of 14 retrospective studies including 2974 participants.
Disclosures: This study was supported by the Startup Fund for Scientific Research, Fujian Medical University, China. No conflicts of interest were declared.
Source: Lin N et al. Prognostic value of neutrophil-to-lymphocyte ratio in colorectal cancer liver metastasis: A meta-analysis of results from multivariate analysis. Int J Surg. 2022;107:106959 (Oct 17). Doi: 10.1016/j.ijsu.2022.106959
Key clinical point: This meta-analysis demonstrated that the elevated pretreatment neutrophil-to-lymphocyte ratio (NLR) was correlated with poor long-term survival in patients with colorectal cancer (CRC) liver metastasis, including those who underwent surgery.
Major finding: Higher NLR was associated with poor overall survival (OS; hazard ratio [HR] 1.95; P < .01) and disease-free survival (DFS; HR 1.80; P < .01), and normal vs elevated NLR was associated with a better OS among patients who underwent surgery (HR 1.95; P < .01). The 5-year OS and DFS rates were higher in patients with normal vs high NLR (both P < .01).
Study details: The data come from a meta-analysis of 14 retrospective studies including 2974 participants.
Disclosures: This study was supported by the Startup Fund for Scientific Research, Fujian Medical University, China. No conflicts of interest were declared.
Source: Lin N et al. Prognostic value of neutrophil-to-lymphocyte ratio in colorectal cancer liver metastasis: A meta-analysis of results from multivariate analysis. Int J Surg. 2022;107:106959 (Oct 17). Doi: 10.1016/j.ijsu.2022.106959