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Breast and Uterine Cancer: Screening Guidelines, Genetic Testing, and Mortality Trends

Author(s)
Haley A. Moss, MD, MBA

Click to view more from Cancer Data Trends 2025. 

References
  1. Shepherd-Banigan M, Zullig LL, Berkowitz TSZ, et al. Improving Cancer Care
    for Women Seeking Services in the Veterans Health Administration Through the
    Breast and Gynecological Oncology System of Excellence. Mil Med. 2024:usae447.
    doi:10.1093/milmed/usae447
  2. US Preventive Services Task Force, Nicholson WK, Silverstein M, et al. Screening
    for Breast Cancer: US Preventive Services Task Force Recommendation Statement.
    JAMA. 2024;331(22):1918-1930. doi:10.1001/jama.2024.5534
  3. VA announces steps to increase life-saving screening, access to benefits for
    Veterans with cancer. VA News. March 8, 2024. Accessed January 14, 2025. https://
    news.va.gov/press-room/va-expands-health-care-benefits-veterans-cancer/
  4. Rezoug Z, Totten SP, Szlachtycz D, et al. Universal Genetic Testing for Newly
    Diagnosed Invasive Breast Cancer. JAMA Netw Open. 2024;7(9):e2431427.
    doi:10.1001/jamanetworkopen.2024.31427
  5. National Institutes of Health. National Cancer Institute. Surveillance, Epidemiology,
    and End Results Program. Cancer Stat Facts: Uterine Cancer. Accessed January 14,
    2025. https://seer.cancer.gov/statfacts/html/corp.html
  6. Clarke MA, Devesa SS, Hammer A, Wentzensen N. Racial and Ethnic Differences in
    Hysterectomy-Corrected Uterine Corpus Cancer Mortality by Stage and Histologic
    Subtype. JAMA Oncol. 2022;8(6):895-903. doi:10.1001/jamaoncol.2022.0009
  7. Moss HA, Rasmussen, KM, Patil, V, et al. Demographic Characteristics of Veterans
    Diagnosed With Breast and Gynecologic Cancers: A Comparative Analysis With the
    General Population. Abstract presented at: Annual Meeting of the Association of
    VA Hematology/Oncology (AVAHO); September 29–October 1, 2023; Chicago, IL.
    Abstract 47.
  8. Breland JY, Frayne SM, Saechao F, Gujral K, Vashi AA, Shaw JG, Gray KM, Illarmo SS,
    Urech T, Grant N, Berg E, Offer C, Veldanda S, Schoemaker L, Dalton AL, Esmaeili
    A, Phibbs CS, Hayes PM, Haskell S. Sourcebook: Women Veterans in the Veterans
    Health Administration. Volume 5: Longitudinal Trends in Sociodemographics and
    Utilization, Including Type, Modality, and Source of Care. Women’s Health Evaluation
    Initiative, Office of Women’s Health, Veterans Health Administration, Department of
    Veterans Affairs, Washington DC. June 2024.
  9. NCCN: National Comprehensive Cancer Network. Breast Cancer Screening and
    Diagnosis. V2.2024 April 9, 2024. Accessed January 14, 2025. https://www.nccn.
    org/professionals/physician_gls/pdf/breast-screening.pdf
  10. ACS: American Cancer Society. Breast Cancer Early Detection and Diagnosis.
    Revised December 19, 2023. Accessed January 14, 2025. https://www.cancer.org/
    cancer/types/breast-cancer/screening-tests-and-early-detection/american-cancersociety-
    recommendations-for-the-early-detection-of-breast-cancer.html
  11. Somasegar S, Bashi A, Lang SM, et al. Trends in Uterine Cancer Mortality
    in the United States: A 50-Year Population-Based Analysis. Obstet Gynecol.
    2023;142(4):978-986. doi:10.1097/AOG.0000000000005321
Author and Disclosure Information

Haley A. Moss, MD, MBA
Assistant Professor, Department of
Obstetrics and Gynecology
Duke University;
Director, Department of Veterans Affairs
Breast and Gynecologic Oncology System
of Excellence
Durham, North Carolina


Dr. Moss has no relevant financial relationships to disclose.

Publications
Federal Practitioner
Topics
Oncology
Breast Cancer
Gynecologic Cancer
Author(s)
Haley A. Moss, MD, MBA
Author(s)
Haley A. Moss, MD, MBA
Author and Disclosure Information

Haley A. Moss, MD, MBA
Assistant Professor, Department of
Obstetrics and Gynecology
Duke University;
Director, Department of Veterans Affairs
Breast and Gynecologic Oncology System
of Excellence
Durham, North Carolina


Dr. Moss has no relevant financial relationships to disclose.

Author and Disclosure Information

Haley A. Moss, MD, MBA
Assistant Professor, Department of
Obstetrics and Gynecology
Duke University;
Director, Department of Veterans Affairs
Breast and Gynecologic Oncology System
of Excellence
Durham, North Carolina


Dr. Moss has no relevant financial relationships to disclose.

Click to view more from Cancer Data Trends 2025. 

Click to view more from Cancer Data Trends 2025. 

References
  1. Shepherd-Banigan M, Zullig LL, Berkowitz TSZ, et al. Improving Cancer Care
    for Women Seeking Services in the Veterans Health Administration Through the
    Breast and Gynecological Oncology System of Excellence. Mil Med. 2024:usae447.
    doi:10.1093/milmed/usae447
  2. US Preventive Services Task Force, Nicholson WK, Silverstein M, et al. Screening
    for Breast Cancer: US Preventive Services Task Force Recommendation Statement.
    JAMA. 2024;331(22):1918-1930. doi:10.1001/jama.2024.5534
  3. VA announces steps to increase life-saving screening, access to benefits for
    Veterans with cancer. VA News. March 8, 2024. Accessed January 14, 2025. https://
    news.va.gov/press-room/va-expands-health-care-benefits-veterans-cancer/
  4. Rezoug Z, Totten SP, Szlachtycz D, et al. Universal Genetic Testing for Newly
    Diagnosed Invasive Breast Cancer. JAMA Netw Open. 2024;7(9):e2431427.
    doi:10.1001/jamanetworkopen.2024.31427
  5. National Institutes of Health. National Cancer Institute. Surveillance, Epidemiology,
    and End Results Program. Cancer Stat Facts: Uterine Cancer. Accessed January 14,
    2025. https://seer.cancer.gov/statfacts/html/corp.html
  6. Clarke MA, Devesa SS, Hammer A, Wentzensen N. Racial and Ethnic Differences in
    Hysterectomy-Corrected Uterine Corpus Cancer Mortality by Stage and Histologic
    Subtype. JAMA Oncol. 2022;8(6):895-903. doi:10.1001/jamaoncol.2022.0009
  7. Moss HA, Rasmussen, KM, Patil, V, et al. Demographic Characteristics of Veterans
    Diagnosed With Breast and Gynecologic Cancers: A Comparative Analysis With the
    General Population. Abstract presented at: Annual Meeting of the Association of
    VA Hematology/Oncology (AVAHO); September 29–October 1, 2023; Chicago, IL.
    Abstract 47.
  8. Breland JY, Frayne SM, Saechao F, Gujral K, Vashi AA, Shaw JG, Gray KM, Illarmo SS,
    Urech T, Grant N, Berg E, Offer C, Veldanda S, Schoemaker L, Dalton AL, Esmaeili
    A, Phibbs CS, Hayes PM, Haskell S. Sourcebook: Women Veterans in the Veterans
    Health Administration. Volume 5: Longitudinal Trends in Sociodemographics and
    Utilization, Including Type, Modality, and Source of Care. Women’s Health Evaluation
    Initiative, Office of Women’s Health, Veterans Health Administration, Department of
    Veterans Affairs, Washington DC. June 2024.
  9. NCCN: National Comprehensive Cancer Network. Breast Cancer Screening and
    Diagnosis. V2.2024 April 9, 2024. Accessed January 14, 2025. https://www.nccn.
    org/professionals/physician_gls/pdf/breast-screening.pdf
  10. ACS: American Cancer Society. Breast Cancer Early Detection and Diagnosis.
    Revised December 19, 2023. Accessed January 14, 2025. https://www.cancer.org/
    cancer/types/breast-cancer/screening-tests-and-early-detection/american-cancersociety-
    recommendations-for-the-early-detection-of-breast-cancer.html
  11. Somasegar S, Bashi A, Lang SM, et al. Trends in Uterine Cancer Mortality
    in the United States: A 50-Year Population-Based Analysis. Obstet Gynecol.
    2023;142(4):978-986. doi:10.1097/AOG.0000000000005321
References
  1. Shepherd-Banigan M, Zullig LL, Berkowitz TSZ, et al. Improving Cancer Care
    for Women Seeking Services in the Veterans Health Administration Through the
    Breast and Gynecological Oncology System of Excellence. Mil Med. 2024:usae447.
    doi:10.1093/milmed/usae447
  2. US Preventive Services Task Force, Nicholson WK, Silverstein M, et al. Screening
    for Breast Cancer: US Preventive Services Task Force Recommendation Statement.
    JAMA. 2024;331(22):1918-1930. doi:10.1001/jama.2024.5534
  3. VA announces steps to increase life-saving screening, access to benefits for
    Veterans with cancer. VA News. March 8, 2024. Accessed January 14, 2025. https://
    news.va.gov/press-room/va-expands-health-care-benefits-veterans-cancer/
  4. Rezoug Z, Totten SP, Szlachtycz D, et al. Universal Genetic Testing for Newly
    Diagnosed Invasive Breast Cancer. JAMA Netw Open. 2024;7(9):e2431427.
    doi:10.1001/jamanetworkopen.2024.31427
  5. National Institutes of Health. National Cancer Institute. Surveillance, Epidemiology,
    and End Results Program. Cancer Stat Facts: Uterine Cancer. Accessed January 14,
    2025. https://seer.cancer.gov/statfacts/html/corp.html
  6. Clarke MA, Devesa SS, Hammer A, Wentzensen N. Racial and Ethnic Differences in
    Hysterectomy-Corrected Uterine Corpus Cancer Mortality by Stage and Histologic
    Subtype. JAMA Oncol. 2022;8(6):895-903. doi:10.1001/jamaoncol.2022.0009
  7. Moss HA, Rasmussen, KM, Patil, V, et al. Demographic Characteristics of Veterans
    Diagnosed With Breast and Gynecologic Cancers: A Comparative Analysis With the
    General Population. Abstract presented at: Annual Meeting of the Association of
    VA Hematology/Oncology (AVAHO); September 29–October 1, 2023; Chicago, IL.
    Abstract 47.
  8. Breland JY, Frayne SM, Saechao F, Gujral K, Vashi AA, Shaw JG, Gray KM, Illarmo SS,
    Urech T, Grant N, Berg E, Offer C, Veldanda S, Schoemaker L, Dalton AL, Esmaeili
    A, Phibbs CS, Hayes PM, Haskell S. Sourcebook: Women Veterans in the Veterans
    Health Administration. Volume 5: Longitudinal Trends in Sociodemographics and
    Utilization, Including Type, Modality, and Source of Care. Women’s Health Evaluation
    Initiative, Office of Women’s Health, Veterans Health Administration, Department of
    Veterans Affairs, Washington DC. June 2024.
  9. NCCN: National Comprehensive Cancer Network. Breast Cancer Screening and
    Diagnosis. V2.2024 April 9, 2024. Accessed January 14, 2025. https://www.nccn.
    org/professionals/physician_gls/pdf/breast-screening.pdf
  10. ACS: American Cancer Society. Breast Cancer Early Detection and Diagnosis.
    Revised December 19, 2023. Accessed January 14, 2025. https://www.cancer.org/
    cancer/types/breast-cancer/screening-tests-and-early-detection/american-cancersociety-
    recommendations-for-the-early-detection-of-breast-cancer.html
  11. Somasegar S, Bashi A, Lang SM, et al. Trends in Uterine Cancer Mortality
    in the United States: A 50-Year Population-Based Analysis. Obstet Gynecol.
    2023;142(4):978-986. doi:10.1097/AOG.0000000000005321
Publications
Federal Practitioner
Publications
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Topics
Oncology
Breast Cancer
Gynecologic Cancer
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Breast and Uterine Cancer: Screening Guidelines, Genetic Testing, and Mortality Trends

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Breast and Uterine Cancer: Screening Guidelines, Genetic Testing, and Mortality Trends

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The VHA Breast and Gynecologic Oncology System of Excellence (BGSoE), established in 2021, provides comprehensive, high-quality cancer care tailored to veterans diagnosed with breast and gynecologic cancers and those considered high-risk based on genetic testing or family history.1 Since its inception, the BGSoE has supported more than 7000 patients.1 For breast cancer, new USPSTF guidelines now recommend initiating biennial mammography at age 40, reflecting efforts to address rising incidence in younger populations.2 The VHA recommends genetic testing for all veterans diagnosed with invasive breast cancer in order to expand access to targeted therapies, facilitate risk reduction for secondary cancers, and enable cascade testing for at-risk family members.3,4

Uterine cancer is a growing concern for veterans, with rising incidence and mortality, particularly in aggressive nonendometrioid subtypes.5,6 Black women in particular have higher uterine cancer mortality rates. This is of particular relevance within the VA, as Black women are overrepresented compared to the general population.6,7 This disparity underscores the need to improve outcomes for all patients while prioritizing targeted interventions for Black women.

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