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Inexplicably drunk: A case of an underdiagnosed condition?
A 46-year-old North Carolina man, who was pulled over on suspicion of drunk driving, vehemently denied consuming alcohol. When he refused to take a breathalyzer test, he was hospitalized and doctors confirmed what police suspected – his blood alcohol level was 0.20, two-and-a-half times the state’s legal limit – and he was charged with driving while intoxicated (DWI).
For an entire year after his arrest, the cause of his “intoxication” remained a mystery. It wasn’t until his aunt learned about a similar case that had been successfully treated at an Ohio clinic that he understood what was happening to him – he had auto brewery syndrome (ABS).
and suffer all the medical and social implications of alcoholism.
“ABS occurs when ingested carbohydrates are converted to alcohol by fungi in the gastrointestinal tract,” Fahad Malik, MD, who reported the case in BMJ Open Gastroenterology while a resident at Richmond University Medical Center in New York, told this news organization.
At the urging of his aunt, the patient attended the Ohio clinic where he underwent a complete blood count, comprehensive metabolic panel, immunology panel and urinalysis, all of which were normal.
However, stool testing revealed the presence of two strains of yeast – Saccharomyces cerevisiae, commonly used in winemaking, baking, and beer brewing, and Saccharomyces boulardii.
To confirm the ABS diagnosis, the patient received a carbohydrate meal and clinicians monitored his blood alcohol level, which, after 8 hours, reached 57 mg/dL. He was treated with antifungals for the Saccharomyces fungi in his stool and discharged on a strict carbohydrate-free diet along with special supplements, including multivitamins and probiotics, but no further antifungal therapy.
Probiotics, said Dr. Malik, competitively inhibit bad bacteria and fungi, but currently there is evidence to show they are useful for ABS.
Although the patient adhered to his prescribed treatment regimen, after a few weeks of no symptoms, intermittent “flares” returned. In one instance of inebriation, he fell and hit his head, resulting in intracranial bleeding that resulted in a transfer to a neurosurgical center. During his hospital stay, his blood alcohol levels ranged from 50 to 400 mg/dL.
Antibiotics the culprit?
Disheartened by the continuation of his symptoms, the patient sought support from an online forum. It was there he read about Dr. Malik and gastroenterologist Prasanna Wickremesinghe, MD (a colleague of Dr. Malik’s at Richmond MC), who had treated a complicated, very similar case of ABS. The patient made contact with the two physicians and they assessed him.
“We went from A to Z with the patient, because we were trying to look for similar things in the history – we wanted to know the exact point at which it started and understand when he started experiencing mental fog,” said Dr. Malik.
After speaking to the patient, Dr. Malik and Dr. Wickremesinghe traced his initial symptoms to a 2011 course of antibiotics (cephalexin 250 mg oral three times a day for 3 weeks) prescribed for a complicated traumatic thumb injury.
About a week after he finished the antibiotics, he experienced noticeable behavioral changes, including depression, brain fog, and aggressive outbursts, all of which were very uncharacteristic.
He visited his primary care physician in 2014 for treatment, which resulted in a referral to a psychiatrist, who treated him with lorazepam and fluoxetine. The patient noted that he was previously healthy, with no significant medical or psychiatric history.
Dr. Malik believes the antibiotics prescribed all those years ago is the culprit. “We were postulating that the antibiotics had changed the microbiome of his gut and allowed the fungi to develop,” he said.
Since there are no established diagnostic criteria or treatment regimen for ABS, Dr. Malik and Dr. Wickremesinghe developed their own.
Diagnosis consisted of a standardized carbohydrate challenge test vs. a carbohydrate meal, where they gave the patient 200 g of glucose by mouth after an overnight fast and drew blood at timed intervals of 0, 0.5, 1, 2, 4, 8, 16, and 24 hours to test for glucose and blood alcohol levels.
“After that we needed to isolate the fungi by examining the gut secretions through an upper and lower endoscopy,” said Dr. Wickremesinghe. Fungal cultures from the upper small gut and cecal secretions grew Candida albicans and C. parapsilosis.
Both fungi were sensitive to azoles and the physicians prescribed oral itraconazole 150 mg per day as an initial therapy. After 10 days, his symptoms did not improve so the dose was increased to 200 mg/day and the patient became “completely asymptomatic.”
“We had nothing to follow. We didn’t know how long to treat the patient, it was really just a process of trial and error,” said Dr. Malik. The physicians asked the patient to monitor his breath alcohol levels twice a day during treatment and immediately report any increases. Over time, he also received treatment with various probiotics to help normalize his gut flora.
Underdiagnosed condition?
At the time of the case study’s publication in the summer of 2019, the patient had been asymptomatic for 18 months and had been able to resume a normal diet, but still checks his breath alcohol levels from time to time.
“Before this patient’s case, I went all through the literature and found only a few cases of ABS,” said Dr. Malik.
However, he added, after this case study was published 10 other patients contacted him with a similar history of antibiotic use and the same symptoms. This, said Dr. Malik, is “significant” and suggests ABS is much more common than previously thought.
The clinicians also note that to the best of their knowledge this is the first report of antibiotic exposure initiating ABS.
“What we tried to do was set up a protocol by which to identify these patients, confirm a diagnosis, and treat them for a sufficient amount of time,” said Dr. Wickremesinghe. “We also wanted to inform other physicians that this may function as a standardized way of treating these patients, and may promote further study,” added Dr. Malik, who emphasized that the role of probiotics in ABS still needs to be studied.
Dr. Malik and Dr. Wickremesinghe note that physicians should be aware that mood changes, brain fog, and delirium in patients who deny alcohol ingestion may be the first symptoms of ABS.
Dr. Wickremesinghe said since the case study was published he and Dr. Malik have received queries from all over the world. “It’s unbelievable the amount of interest we have had in the paper, so if we have made the medical community and the general population aware of this condition and how to treat it, we have done a major thing for medicine,” he said.
A version of this article first appeared on Medscape.com.
A 46-year-old North Carolina man, who was pulled over on suspicion of drunk driving, vehemently denied consuming alcohol. When he refused to take a breathalyzer test, he was hospitalized and doctors confirmed what police suspected – his blood alcohol level was 0.20, two-and-a-half times the state’s legal limit – and he was charged with driving while intoxicated (DWI).
For an entire year after his arrest, the cause of his “intoxication” remained a mystery. It wasn’t until his aunt learned about a similar case that had been successfully treated at an Ohio clinic that he understood what was happening to him – he had auto brewery syndrome (ABS).
and suffer all the medical and social implications of alcoholism.
“ABS occurs when ingested carbohydrates are converted to alcohol by fungi in the gastrointestinal tract,” Fahad Malik, MD, who reported the case in BMJ Open Gastroenterology while a resident at Richmond University Medical Center in New York, told this news organization.
At the urging of his aunt, the patient attended the Ohio clinic where he underwent a complete blood count, comprehensive metabolic panel, immunology panel and urinalysis, all of which were normal.
However, stool testing revealed the presence of two strains of yeast – Saccharomyces cerevisiae, commonly used in winemaking, baking, and beer brewing, and Saccharomyces boulardii.
To confirm the ABS diagnosis, the patient received a carbohydrate meal and clinicians monitored his blood alcohol level, which, after 8 hours, reached 57 mg/dL. He was treated with antifungals for the Saccharomyces fungi in his stool and discharged on a strict carbohydrate-free diet along with special supplements, including multivitamins and probiotics, but no further antifungal therapy.
Probiotics, said Dr. Malik, competitively inhibit bad bacteria and fungi, but currently there is evidence to show they are useful for ABS.
Although the patient adhered to his prescribed treatment regimen, after a few weeks of no symptoms, intermittent “flares” returned. In one instance of inebriation, he fell and hit his head, resulting in intracranial bleeding that resulted in a transfer to a neurosurgical center. During his hospital stay, his blood alcohol levels ranged from 50 to 400 mg/dL.
Antibiotics the culprit?
Disheartened by the continuation of his symptoms, the patient sought support from an online forum. It was there he read about Dr. Malik and gastroenterologist Prasanna Wickremesinghe, MD (a colleague of Dr. Malik’s at Richmond MC), who had treated a complicated, very similar case of ABS. The patient made contact with the two physicians and they assessed him.
“We went from A to Z with the patient, because we were trying to look for similar things in the history – we wanted to know the exact point at which it started and understand when he started experiencing mental fog,” said Dr. Malik.
After speaking to the patient, Dr. Malik and Dr. Wickremesinghe traced his initial symptoms to a 2011 course of antibiotics (cephalexin 250 mg oral three times a day for 3 weeks) prescribed for a complicated traumatic thumb injury.
About a week after he finished the antibiotics, he experienced noticeable behavioral changes, including depression, brain fog, and aggressive outbursts, all of which were very uncharacteristic.
He visited his primary care physician in 2014 for treatment, which resulted in a referral to a psychiatrist, who treated him with lorazepam and fluoxetine. The patient noted that he was previously healthy, with no significant medical or psychiatric history.
Dr. Malik believes the antibiotics prescribed all those years ago is the culprit. “We were postulating that the antibiotics had changed the microbiome of his gut and allowed the fungi to develop,” he said.
Since there are no established diagnostic criteria or treatment regimen for ABS, Dr. Malik and Dr. Wickremesinghe developed their own.
Diagnosis consisted of a standardized carbohydrate challenge test vs. a carbohydrate meal, where they gave the patient 200 g of glucose by mouth after an overnight fast and drew blood at timed intervals of 0, 0.5, 1, 2, 4, 8, 16, and 24 hours to test for glucose and blood alcohol levels.
“After that we needed to isolate the fungi by examining the gut secretions through an upper and lower endoscopy,” said Dr. Wickremesinghe. Fungal cultures from the upper small gut and cecal secretions grew Candida albicans and C. parapsilosis.
Both fungi were sensitive to azoles and the physicians prescribed oral itraconazole 150 mg per day as an initial therapy. After 10 days, his symptoms did not improve so the dose was increased to 200 mg/day and the patient became “completely asymptomatic.”
“We had nothing to follow. We didn’t know how long to treat the patient, it was really just a process of trial and error,” said Dr. Malik. The physicians asked the patient to monitor his breath alcohol levels twice a day during treatment and immediately report any increases. Over time, he also received treatment with various probiotics to help normalize his gut flora.
Underdiagnosed condition?
At the time of the case study’s publication in the summer of 2019, the patient had been asymptomatic for 18 months and had been able to resume a normal diet, but still checks his breath alcohol levels from time to time.
“Before this patient’s case, I went all through the literature and found only a few cases of ABS,” said Dr. Malik.
However, he added, after this case study was published 10 other patients contacted him with a similar history of antibiotic use and the same symptoms. This, said Dr. Malik, is “significant” and suggests ABS is much more common than previously thought.
The clinicians also note that to the best of their knowledge this is the first report of antibiotic exposure initiating ABS.
“What we tried to do was set up a protocol by which to identify these patients, confirm a diagnosis, and treat them for a sufficient amount of time,” said Dr. Wickremesinghe. “We also wanted to inform other physicians that this may function as a standardized way of treating these patients, and may promote further study,” added Dr. Malik, who emphasized that the role of probiotics in ABS still needs to be studied.
Dr. Malik and Dr. Wickremesinghe note that physicians should be aware that mood changes, brain fog, and delirium in patients who deny alcohol ingestion may be the first symptoms of ABS.
Dr. Wickremesinghe said since the case study was published he and Dr. Malik have received queries from all over the world. “It’s unbelievable the amount of interest we have had in the paper, so if we have made the medical community and the general population aware of this condition and how to treat it, we have done a major thing for medicine,” he said.
A version of this article first appeared on Medscape.com.
A 46-year-old North Carolina man, who was pulled over on suspicion of drunk driving, vehemently denied consuming alcohol. When he refused to take a breathalyzer test, he was hospitalized and doctors confirmed what police suspected – his blood alcohol level was 0.20, two-and-a-half times the state’s legal limit – and he was charged with driving while intoxicated (DWI).
For an entire year after his arrest, the cause of his “intoxication” remained a mystery. It wasn’t until his aunt learned about a similar case that had been successfully treated at an Ohio clinic that he understood what was happening to him – he had auto brewery syndrome (ABS).
and suffer all the medical and social implications of alcoholism.
“ABS occurs when ingested carbohydrates are converted to alcohol by fungi in the gastrointestinal tract,” Fahad Malik, MD, who reported the case in BMJ Open Gastroenterology while a resident at Richmond University Medical Center in New York, told this news organization.
At the urging of his aunt, the patient attended the Ohio clinic where he underwent a complete blood count, comprehensive metabolic panel, immunology panel and urinalysis, all of which were normal.
However, stool testing revealed the presence of two strains of yeast – Saccharomyces cerevisiae, commonly used in winemaking, baking, and beer brewing, and Saccharomyces boulardii.
To confirm the ABS diagnosis, the patient received a carbohydrate meal and clinicians monitored his blood alcohol level, which, after 8 hours, reached 57 mg/dL. He was treated with antifungals for the Saccharomyces fungi in his stool and discharged on a strict carbohydrate-free diet along with special supplements, including multivitamins and probiotics, but no further antifungal therapy.
Probiotics, said Dr. Malik, competitively inhibit bad bacteria and fungi, but currently there is evidence to show they are useful for ABS.
Although the patient adhered to his prescribed treatment regimen, after a few weeks of no symptoms, intermittent “flares” returned. In one instance of inebriation, he fell and hit his head, resulting in intracranial bleeding that resulted in a transfer to a neurosurgical center. During his hospital stay, his blood alcohol levels ranged from 50 to 400 mg/dL.
Antibiotics the culprit?
Disheartened by the continuation of his symptoms, the patient sought support from an online forum. It was there he read about Dr. Malik and gastroenterologist Prasanna Wickremesinghe, MD (a colleague of Dr. Malik’s at Richmond MC), who had treated a complicated, very similar case of ABS. The patient made contact with the two physicians and they assessed him.
“We went from A to Z with the patient, because we were trying to look for similar things in the history – we wanted to know the exact point at which it started and understand when he started experiencing mental fog,” said Dr. Malik.
After speaking to the patient, Dr. Malik and Dr. Wickremesinghe traced his initial symptoms to a 2011 course of antibiotics (cephalexin 250 mg oral three times a day for 3 weeks) prescribed for a complicated traumatic thumb injury.
About a week after he finished the antibiotics, he experienced noticeable behavioral changes, including depression, brain fog, and aggressive outbursts, all of which were very uncharacteristic.
He visited his primary care physician in 2014 for treatment, which resulted in a referral to a psychiatrist, who treated him with lorazepam and fluoxetine. The patient noted that he was previously healthy, with no significant medical or psychiatric history.
Dr. Malik believes the antibiotics prescribed all those years ago is the culprit. “We were postulating that the antibiotics had changed the microbiome of his gut and allowed the fungi to develop,” he said.
Since there are no established diagnostic criteria or treatment regimen for ABS, Dr. Malik and Dr. Wickremesinghe developed their own.
Diagnosis consisted of a standardized carbohydrate challenge test vs. a carbohydrate meal, where they gave the patient 200 g of glucose by mouth after an overnight fast and drew blood at timed intervals of 0, 0.5, 1, 2, 4, 8, 16, and 24 hours to test for glucose and blood alcohol levels.
“After that we needed to isolate the fungi by examining the gut secretions through an upper and lower endoscopy,” said Dr. Wickremesinghe. Fungal cultures from the upper small gut and cecal secretions grew Candida albicans and C. parapsilosis.
Both fungi were sensitive to azoles and the physicians prescribed oral itraconazole 150 mg per day as an initial therapy. After 10 days, his symptoms did not improve so the dose was increased to 200 mg/day and the patient became “completely asymptomatic.”
“We had nothing to follow. We didn’t know how long to treat the patient, it was really just a process of trial and error,” said Dr. Malik. The physicians asked the patient to monitor his breath alcohol levels twice a day during treatment and immediately report any increases. Over time, he also received treatment with various probiotics to help normalize his gut flora.
Underdiagnosed condition?
At the time of the case study’s publication in the summer of 2019, the patient had been asymptomatic for 18 months and had been able to resume a normal diet, but still checks his breath alcohol levels from time to time.
“Before this patient’s case, I went all through the literature and found only a few cases of ABS,” said Dr. Malik.
However, he added, after this case study was published 10 other patients contacted him with a similar history of antibiotic use and the same symptoms. This, said Dr. Malik, is “significant” and suggests ABS is much more common than previously thought.
The clinicians also note that to the best of their knowledge this is the first report of antibiotic exposure initiating ABS.
“What we tried to do was set up a protocol by which to identify these patients, confirm a diagnosis, and treat them for a sufficient amount of time,” said Dr. Wickremesinghe. “We also wanted to inform other physicians that this may function as a standardized way of treating these patients, and may promote further study,” added Dr. Malik, who emphasized that the role of probiotics in ABS still needs to be studied.
Dr. Malik and Dr. Wickremesinghe note that physicians should be aware that mood changes, brain fog, and delirium in patients who deny alcohol ingestion may be the first symptoms of ABS.
Dr. Wickremesinghe said since the case study was published he and Dr. Malik have received queries from all over the world. “It’s unbelievable the amount of interest we have had in the paper, so if we have made the medical community and the general population aware of this condition and how to treat it, we have done a major thing for medicine,” he said.
A version of this article first appeared on Medscape.com.
New data may help intercept head injuries in college football
Novel research from the Concussion Assessment, Research and Education (CARE) Consortium sheds new light on how to effectively reduce the incidence of concussion and head injury exposure in college football.
The study, led by neurotrauma experts Michael McCrea, PhD, and Brian Stemper, PhD, professors of neurosurgery at the Medical College of Wisconsin in Milwaukee, reports data from hundreds of college football players across five seasons and shows 
The research also reveals that such injuries occur more often during practices than games.
“We think that with the findings from this paper, there’s a role for everybody to play in reducing injury,” Dr. McCrea said. “We hope these data help inform broad-based policy about practice and preseason training policies in collegiate football. We also think there’s a role for athletic administrators, coaches, and even athletes themselves.”
The study was published online Feb. 1 in JAMA Neurology.
More injuries in preseason
Concussion is one of the most common injuries in football. Beyond these harms are growing concerns that repetitive HIE may increase the risk of long-term neurologic health problems including chronic traumatic encephalopathy (CTE).
The CARE Consortium, which has been conducting research with college athletes across 26 sports and military cadets since 2014, has been interested in multiple facets of concussion and brain trauma.
“We’ve enrolled more than 50,000 athletes and service academy cadets into the consortium over the last 6 years to research all involved aspects including the clinical core, the imaging core, the blood biomarker core, and the genetic core, and we have a head impact measurement core.”
To investigate the pattern of concussion incidence across the football season in college players, the investigators used impact measurement technology across six Division I NCAA football programs participating in the CARE Consortium from 2015 to 2019.
A total of 658 players – all male, mean age 19 years – were fitted with the Head Impact Telemetry System (HITS) sensor arrays in their helmets to measure head impact frequency, location, and magnitude during play.
“This particular study had built-in algorithms that weeded out impacts that were below 10G of linear magnitude, because those have been determined not likely to be real impacts,” Dr. McCrea said.
Across the five seasons studied, 528,684 head impacts recorded met the quality standards for analysis. Players sustained a median of 415 (interquartile range [IQR], 190-727) impacts per season.
Of those, 68 players sustained a diagnosed concussion. In total, 48.5% of concussions occurred during preseason training, despite preseason representing only 20.8% of the football season. Total head injury exposure in the preseason occurred at twice the proportion of the regular season (324.9 vs. 162.4 impacts per team per day; mean difference, 162.6 impacts; 95% confidence interval, 110.9-214.3; P < .001).
“Preseason training often has a much higher intensity to it, in terms of the total hours, the actual training, and the heavy emphasis on full-contact drills like tackling and blocking,” said Dr. McCrea. “Even the volume of players that are participating is greater.”
Results also showed that in each of the five seasons, head injury exposure per athlete was highest in August (preseason) (median, 146.0 impacts; IQR, 63.0-247.8) and lowest in November (median, 80.0 impacts; IQR, 35.0-148.0). In the studied period, 72% of concussions and 66.9% of head injury exposure occurred in practice. Even within the regular season, total head injury exposure in practices was 84.2% higher than in games.
“This incredible dataset we have on head impact measurement also gives us the opportunity to compare it with our other research looking at the correlation between a single head impact and changes in brain structure and function on MRI, on blood biomarkers, giving us the ability to look at the connection between mechanism of effect of injury and recovery from injury,” said Dr. McCrea.
These findings also provide an opportunity to modify approaches to preseason training and football practices to keep players safer, said Dr. McCrea, noting that about half of the variance in head injury exposure is at the level of the individual athlete.
“With this large body of athletes we’ve instrumented, we can look at, for instance, all of the running backs and understand the athlete and what his head injury exposure looks like compared to all other running backs. If we find out that an athlete has a rate of head injury exposure that’s 300% higher than most other players that play the same position, we can take that data directly to the athlete to work on their technique and approach to the game.
“Every researcher wishes that their basic science or their clinical research findings will have some impact on the health and well-being of the population they’re studying. By modifying practices and preseason training, football teams could greatly reduce the risk of injury and exposure for their players, while still maintaining the competitive nature of game play,” he added.
Through a combination of policy and education, similar strategies could be implemented to help prevent concussion and HIE in high school and youth football too, said Dr. McCrea.
‘Shocking’ findings
In an accompanying editorial, Christopher J. Nowinski, PhD, of the Concussion Legacy Foundation, Boston, and Robert C. Cantu, MD, department of neurosurgery, Emerson Hospital, Concord, Massachusetts, said the findings could have significant policy implications and offer a valuable expansion of prior research.
“From 2005 to 2010, studies on college football revealed that about two-thirds of head impacts occurred in practice,” they noted. “We cited this data in 2010 when we proposed to the NFL Players Association that the most effective way to reduce the risks of negative neurological outcomes was to reduce hitting in practice. They agreed, and in 2011 collectively bargained for severe contact limits in practice, with 14 full-contact practices allowed during the 17-week season. Since that rule was implemented, only 18% of NFL concussions have occurred in practice.”
“Against this backdrop, the results of the study by McCrea et al. are shocking,” they added. “It reveals that college football players still experience 72% of their concussions and 67% of their total head injury exposure in practice.”
Even more shocking, noted Dr. Nowinski and Dr. Cantu, is that these numbers are almost certainly an underestimate of the dangers of practice.
“As a former college football player and a former team physician, respectively, we find this situation inexcusable. Concussions in games are inevitable, but concussions in practice are preventable,” they wrote.
“Laudably,” they added “the investigators call on the NCAA and football conferences to explore policy and rule changes to reduce concussion incidence and HIE and to create robust educational offerings to encourage change from coaches and college administrators.”
A version of this article first appeared on Medscape.com.
Novel research from the Concussion Assessment, Research and Education (CARE) Consortium sheds new light on how to effectively reduce the incidence of concussion and head injury exposure in college football.
The study, led by neurotrauma experts Michael McCrea, PhD, and Brian Stemper, PhD, professors of neurosurgery at the Medical College of Wisconsin in Milwaukee, reports data from hundreds of college football players across five seasons and shows
The research also reveals that such injuries occur more often during practices than games.
“We think that with the findings from this paper, there’s a role for everybody to play in reducing injury,” Dr. McCrea said. “We hope these data help inform broad-based policy about practice and preseason training policies in collegiate football. We also think there’s a role for athletic administrators, coaches, and even athletes themselves.”
The study was published online Feb. 1 in JAMA Neurology.
More injuries in preseason
Concussion is one of the most common injuries in football. Beyond these harms are growing concerns that repetitive HIE may increase the risk of long-term neurologic health problems including chronic traumatic encephalopathy (CTE).
The CARE Consortium, which has been conducting research with college athletes across 26 sports and military cadets since 2014, has been interested in multiple facets of concussion and brain trauma.
“We’ve enrolled more than 50,000 athletes and service academy cadets into the consortium over the last 6 years to research all involved aspects including the clinical core, the imaging core, the blood biomarker core, and the genetic core, and we have a head impact measurement core.”
To investigate the pattern of concussion incidence across the football season in college players, the investigators used impact measurement technology across six Division I NCAA football programs participating in the CARE Consortium from 2015 to 2019.
A total of 658 players – all male, mean age 19 years – were fitted with the Head Impact Telemetry System (HITS) sensor arrays in their helmets to measure head impact frequency, location, and magnitude during play.
“This particular study had built-in algorithms that weeded out impacts that were below 10G of linear magnitude, because those have been determined not likely to be real impacts,” Dr. McCrea said.
Across the five seasons studied, 528,684 head impacts recorded met the quality standards for analysis. Players sustained a median of 415 (interquartile range [IQR], 190-727) impacts per season.
Of those, 68 players sustained a diagnosed concussion. In total, 48.5% of concussions occurred during preseason training, despite preseason representing only 20.8% of the football season. Total head injury exposure in the preseason occurred at twice the proportion of the regular season (324.9 vs. 162.4 impacts per team per day; mean difference, 162.6 impacts; 95% confidence interval, 110.9-214.3; P < .001).
“Preseason training often has a much higher intensity to it, in terms of the total hours, the actual training, and the heavy emphasis on full-contact drills like tackling and blocking,” said Dr. McCrea. “Even the volume of players that are participating is greater.”
Results also showed that in each of the five seasons, head injury exposure per athlete was highest in August (preseason) (median, 146.0 impacts; IQR, 63.0-247.8) and lowest in November (median, 80.0 impacts; IQR, 35.0-148.0). In the studied period, 72% of concussions and 66.9% of head injury exposure occurred in practice. Even within the regular season, total head injury exposure in practices was 84.2% higher than in games.
“This incredible dataset we have on head impact measurement also gives us the opportunity to compare it with our other research looking at the correlation between a single head impact and changes in brain structure and function on MRI, on blood biomarkers, giving us the ability to look at the connection between mechanism of effect of injury and recovery from injury,” said Dr. McCrea.
These findings also provide an opportunity to modify approaches to preseason training and football practices to keep players safer, said Dr. McCrea, noting that about half of the variance in head injury exposure is at the level of the individual athlete.
“With this large body of athletes we’ve instrumented, we can look at, for instance, all of the running backs and understand the athlete and what his head injury exposure looks like compared to all other running backs. If we find out that an athlete has a rate of head injury exposure that’s 300% higher than most other players that play the same position, we can take that data directly to the athlete to work on their technique and approach to the game.
“Every researcher wishes that their basic science or their clinical research findings will have some impact on the health and well-being of the population they’re studying. By modifying practices and preseason training, football teams could greatly reduce the risk of injury and exposure for their players, while still maintaining the competitive nature of game play,” he added.
Through a combination of policy and education, similar strategies could be implemented to help prevent concussion and HIE in high school and youth football too, said Dr. McCrea.
‘Shocking’ findings
In an accompanying editorial, Christopher J. Nowinski, PhD, of the Concussion Legacy Foundation, Boston, and Robert C. Cantu, MD, department of neurosurgery, Emerson Hospital, Concord, Massachusetts, said the findings could have significant policy implications and offer a valuable expansion of prior research.
“From 2005 to 2010, studies on college football revealed that about two-thirds of head impacts occurred in practice,” they noted. “We cited this data in 2010 when we proposed to the NFL Players Association that the most effective way to reduce the risks of negative neurological outcomes was to reduce hitting in practice. They agreed, and in 2011 collectively bargained for severe contact limits in practice, with 14 full-contact practices allowed during the 17-week season. Since that rule was implemented, only 18% of NFL concussions have occurred in practice.”
“Against this backdrop, the results of the study by McCrea et al. are shocking,” they added. “It reveals that college football players still experience 72% of their concussions and 67% of their total head injury exposure in practice.”
Even more shocking, noted Dr. Nowinski and Dr. Cantu, is that these numbers are almost certainly an underestimate of the dangers of practice.
“As a former college football player and a former team physician, respectively, we find this situation inexcusable. Concussions in games are inevitable, but concussions in practice are preventable,” they wrote.
“Laudably,” they added “the investigators call on the NCAA and football conferences to explore policy and rule changes to reduce concussion incidence and HIE and to create robust educational offerings to encourage change from coaches and college administrators.”
A version of this article first appeared on Medscape.com.
Novel research from the Concussion Assessment, Research and Education (CARE) Consortium sheds new light on how to effectively reduce the incidence of concussion and head injury exposure in college football.
The study, led by neurotrauma experts Michael McCrea, PhD, and Brian Stemper, PhD, professors of neurosurgery at the Medical College of Wisconsin in Milwaukee, reports data from hundreds of college football players across five seasons and shows
The research also reveals that such injuries occur more often during practices than games.
“We think that with the findings from this paper, there’s a role for everybody to play in reducing injury,” Dr. McCrea said. “We hope these data help inform broad-based policy about practice and preseason training policies in collegiate football. We also think there’s a role for athletic administrators, coaches, and even athletes themselves.”
The study was published online Feb. 1 in JAMA Neurology.
More injuries in preseason
Concussion is one of the most common injuries in football. Beyond these harms are growing concerns that repetitive HIE may increase the risk of long-term neurologic health problems including chronic traumatic encephalopathy (CTE).
The CARE Consortium, which has been conducting research with college athletes across 26 sports and military cadets since 2014, has been interested in multiple facets of concussion and brain trauma.
“We’ve enrolled more than 50,000 athletes and service academy cadets into the consortium over the last 6 years to research all involved aspects including the clinical core, the imaging core, the blood biomarker core, and the genetic core, and we have a head impact measurement core.”
To investigate the pattern of concussion incidence across the football season in college players, the investigators used impact measurement technology across six Division I NCAA football programs participating in the CARE Consortium from 2015 to 2019.
A total of 658 players – all male, mean age 19 years – were fitted with the Head Impact Telemetry System (HITS) sensor arrays in their helmets to measure head impact frequency, location, and magnitude during play.
“This particular study had built-in algorithms that weeded out impacts that were below 10G of linear magnitude, because those have been determined not likely to be real impacts,” Dr. McCrea said.
Across the five seasons studied, 528,684 head impacts recorded met the quality standards for analysis. Players sustained a median of 415 (interquartile range [IQR], 190-727) impacts per season.
Of those, 68 players sustained a diagnosed concussion. In total, 48.5% of concussions occurred during preseason training, despite preseason representing only 20.8% of the football season. Total head injury exposure in the preseason occurred at twice the proportion of the regular season (324.9 vs. 162.4 impacts per team per day; mean difference, 162.6 impacts; 95% confidence interval, 110.9-214.3; P < .001).
“Preseason training often has a much higher intensity to it, in terms of the total hours, the actual training, and the heavy emphasis on full-contact drills like tackling and blocking,” said Dr. McCrea. “Even the volume of players that are participating is greater.”
Results also showed that in each of the five seasons, head injury exposure per athlete was highest in August (preseason) (median, 146.0 impacts; IQR, 63.0-247.8) and lowest in November (median, 80.0 impacts; IQR, 35.0-148.0). In the studied period, 72% of concussions and 66.9% of head injury exposure occurred in practice. Even within the regular season, total head injury exposure in practices was 84.2% higher than in games.
“This incredible dataset we have on head impact measurement also gives us the opportunity to compare it with our other research looking at the correlation between a single head impact and changes in brain structure and function on MRI, on blood biomarkers, giving us the ability to look at the connection between mechanism of effect of injury and recovery from injury,” said Dr. McCrea.
These findings also provide an opportunity to modify approaches to preseason training and football practices to keep players safer, said Dr. McCrea, noting that about half of the variance in head injury exposure is at the level of the individual athlete.
“With this large body of athletes we’ve instrumented, we can look at, for instance, all of the running backs and understand the athlete and what his head injury exposure looks like compared to all other running backs. If we find out that an athlete has a rate of head injury exposure that’s 300% higher than most other players that play the same position, we can take that data directly to the athlete to work on their technique and approach to the game.
“Every researcher wishes that their basic science or their clinical research findings will have some impact on the health and well-being of the population they’re studying. By modifying practices and preseason training, football teams could greatly reduce the risk of injury and exposure for their players, while still maintaining the competitive nature of game play,” he added.
Through a combination of policy and education, similar strategies could be implemented to help prevent concussion and HIE in high school and youth football too, said Dr. McCrea.
‘Shocking’ findings
In an accompanying editorial, Christopher J. Nowinski, PhD, of the Concussion Legacy Foundation, Boston, and Robert C. Cantu, MD, department of neurosurgery, Emerson Hospital, Concord, Massachusetts, said the findings could have significant policy implications and offer a valuable expansion of prior research.
“From 2005 to 2010, studies on college football revealed that about two-thirds of head impacts occurred in practice,” they noted. “We cited this data in 2010 when we proposed to the NFL Players Association that the most effective way to reduce the risks of negative neurological outcomes was to reduce hitting in practice. They agreed, and in 2011 collectively bargained for severe contact limits in practice, with 14 full-contact practices allowed during the 17-week season. Since that rule was implemented, only 18% of NFL concussions have occurred in practice.”
“Against this backdrop, the results of the study by McCrea et al. are shocking,” they added. “It reveals that college football players still experience 72% of their concussions and 67% of their total head injury exposure in practice.”
Even more shocking, noted Dr. Nowinski and Dr. Cantu, is that these numbers are almost certainly an underestimate of the dangers of practice.
“As a former college football player and a former team physician, respectively, we find this situation inexcusable. Concussions in games are inevitable, but concussions in practice are preventable,” they wrote.
“Laudably,” they added “the investigators call on the NCAA and football conferences to explore policy and rule changes to reduce concussion incidence and HIE and to create robust educational offerings to encourage change from coaches and college administrators.”
A version of this article first appeared on Medscape.com.
FROM JAMA NEUROLOGY