Finnian Mc Causland, MD

We thank Drs. Liu and Zhang for their letter and comments. Each diagnostic code in our dataset was individually reviewed by a board‐certified senior orthopedic surgeon (Dr. Wright). We considered procedures as major if they were of long duration, had the potential for significant blood loss, or represented major physiologic stress, including significant fluid balance requirements, in the opinion of our orthopedist coauthor. This set of diagnoses did include femoral neck fractures.

In our original analyses, we included fracture as a covariate in all statistical models and subsequently performed subgroup analyses according to the presence or absence of a diagnosis of fracture. As reported in our article,[1] J‐shaped associations of dysnatremia with greater length of stay were evident in those with and without fractures. In the 30‐day mortality analyses, only mild hyponatremia and hypernatremia remained associated with greater mortality in those with fracture. In those without a diagnosis of fracture, only moderate/severe hyponatremia remained associated with greater 30‐day mortality.

To assess for differences in associations of hyponatremia with outcomes according to age, we dichotomized this variable into those <65 years old versus 65 years old. We then fit model 3 from our original article to determine the adjusted effect estimates for length of stay and 30‐day mortality (Tables 1 and 2, respectively).

While the associations of dysnatremia with 30‐day mortality did not reach statistical significance in the <65 years age group, these results must be interpreted with caution due to the low number of events (35 deaths). We did not perform smaller subgroups analyses according to fracture type due to concerns of multiple comparisons testing, loss of statistical power, and inaccurate interpretation of effect estimates.

We thank Drs. Liu and Zhang for their letter and comments. Each diagnostic code in our dataset was individually reviewed by a board‐certified senior orthopedic surgeon (Dr. Wright). We considered procedures as major if they were of long duration, had the potential for significant blood loss, or represented major physiologic stress, including significant fluid balance requirements, in the opinion of our orthopedist coauthor. This set of diagnoses did include femoral neck fractures.

In our original analyses, we included fracture as a covariate in all statistical models and subsequently performed subgroup analyses according to the presence or absence of a diagnosis of fracture. As reported in our article,[1] J‐shaped associations of dysnatremia with greater length of stay were evident in those with and without fractures. In the 30‐day mortality analyses, only mild hyponatremia and hypernatremia remained associated with greater mortality in those with fracture. In those without a diagnosis of fracture, only moderate/severe hyponatremia remained associated with greater 30‐day mortality.

To assess for differences in associations of hyponatremia with outcomes according to age, we dichotomized this variable into those <65 years old versus 65 years old. We then fit model 3 from our original article to determine the adjusted effect estimates for length of stay and 30‐day mortality (Tables 1 and 2, respectively).

While the associations of dysnatremia with 30‐day mortality did not reach statistical significance in the <65 years age group, these results must be interpreted with caution due to the low number of events (35 deaths). We did not perform smaller subgroups analyses according to fracture type due to concerns of multiple comparisons testing, loss of statistical power, and inaccurate interpretation of effect estimates.

We thank Drs. Liu and Zhang for their letter and comments. Each diagnostic code in our dataset was individually reviewed by a board‐certified senior orthopedic surgeon (Dr. Wright). We considered procedures as major if they were of long duration, had the potential for significant blood loss, or represented major physiologic stress, including significant fluid balance requirements, in the opinion of our orthopedist coauthor. This set of diagnoses did include femoral neck fractures.

In our original analyses, we included fracture as a covariate in all statistical models and subsequently performed subgroup analyses according to the presence or absence of a diagnosis of fracture. As reported in our article,[1] J‐shaped associations of dysnatremia with greater length of stay were evident in those with and without fractures. In the 30‐day mortality analyses, only mild hyponatremia and hypernatremia remained associated with greater mortality in those with fracture. In those without a diagnosis of fracture, only moderate/severe hyponatremia remained associated with greater 30‐day mortality.

To assess for differences in associations of hyponatremia with outcomes according to age, we dichotomized this variable into those <65 years old versus 65 years old. We then fit model 3 from our original article to determine the adjusted effect estimates for length of stay and 30‐day mortality (Tables 1 and 2, respectively).

While the associations of dysnatremia with 30‐day mortality did not reach statistical significance in the <65 years age group, these results must be interpreted with caution due to the low number of events (35 deaths). We did not perform smaller subgroups analyses according to fracture type due to concerns of multiple comparisons testing, loss of statistical power, and inaccurate interpretation of effect estimates.