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Key clinical point: Compared with the general population, patients with multiple sclerosis (MS) may be at a slightly higher risk of developing myocardial infarction (MI) but not stroke.
Major finding: An increased risk for MI was found to be causally associated with MS (odds ratio [OR], 1.03; P = .0243). MS and stroke showed no significant causal association (OR, 1.01; P = .2974).
Study details: This was a 2-sample Mendelian randomization analysis of genetic summary data for MS (14,498 patients and 24,091 healthy controls), MI (43,676 patients and 128,199 healthy controls), and stroke (40,585 patients and 446,696 healthy controls) from large-scale genome-wide association studies.
Disclosures: The study was supported by Cultivation of Guangdong College Students' Scientific and Technological Innovation. The authors declared no conflict of interests.
Source: Peng H et al. Mult Scler Relat Disord. 2022 Jan 6. doi: 10.1016/j.msard.2022.103501.
Key clinical point: Compared with the general population, patients with multiple sclerosis (MS) may be at a slightly higher risk of developing myocardial infarction (MI) but not stroke.
Major finding: An increased risk for MI was found to be causally associated with MS (odds ratio [OR], 1.03; P = .0243). MS and stroke showed no significant causal association (OR, 1.01; P = .2974).
Study details: This was a 2-sample Mendelian randomization analysis of genetic summary data for MS (14,498 patients and 24,091 healthy controls), MI (43,676 patients and 128,199 healthy controls), and stroke (40,585 patients and 446,696 healthy controls) from large-scale genome-wide association studies.
Disclosures: The study was supported by Cultivation of Guangdong College Students' Scientific and Technological Innovation. The authors declared no conflict of interests.
Source: Peng H et al. Mult Scler Relat Disord. 2022 Jan 6. doi: 10.1016/j.msard.2022.103501.
Key clinical point: Compared with the general population, patients with multiple sclerosis (MS) may be at a slightly higher risk of developing myocardial infarction (MI) but not stroke.
Major finding: An increased risk for MI was found to be causally associated with MS (odds ratio [OR], 1.03; P = .0243). MS and stroke showed no significant causal association (OR, 1.01; P = .2974).
Study details: This was a 2-sample Mendelian randomization analysis of genetic summary data for MS (14,498 patients and 24,091 healthy controls), MI (43,676 patients and 128,199 healthy controls), and stroke (40,585 patients and 446,696 healthy controls) from large-scale genome-wide association studies.
Disclosures: The study was supported by Cultivation of Guangdong College Students' Scientific and Technological Innovation. The authors declared no conflict of interests.
Source: Peng H et al. Mult Scler Relat Disord. 2022 Jan 6. doi: 10.1016/j.msard.2022.103501.