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One Veterans Affairs Medical Center’s Experience with Colorectal Carcinoma
Gavrancic T, Liu Q, Jain V, Park Y-HA.

Purpose: This study was performed in order to evaluate if patients were offered or received appropriate workup and treatment according to colon cancer stage. Rectal cancer was diagnosed in 3 and colon cancer in 81 patients over 5 years.  Patients were diagnosed with stage I in 26 cases (30%), stage II in 21 cases (25%), stage III in 15 cases (17.9 %), stage IV in 21 cases (25%), and 1 patient TIS (0.1%).

Methods: The study was designed as a retrospective single institution (JJP VAMC ) chart review of all patients who were diagnosed with colorectal cancer from 1/1/2008-12/31/2012 which included a total of 86 patients. NCCN guidelines 2014 were used as reference for workup, treatment and surveillance according to TNM classification. Data elements included the following: pre-operative CEA/ CT chest, abdomen, pelvis, colonoscopy; surgical resection and chemotherapy; follow up CEA, CT, colonoscopy. Excluded patients included those who eloped or were permanently lost follow up.

Results: Complete workup was done in 64% cases, incomplete in 36% cases without significant difference from 2008-2012. Incomplete workup defined as: missing CT chest (in 100% of those cases CXR was done and without mass suggestive for metastasis) 11 cases, CEA 3 cases, CT abdomen, pelvis and chest in 1 case, and both CT and CEA in 7 cases.  Stage IV colorectal carcinoma patients were tested for KRAS/BRAF in 10 cases  (47.6%; 3 KRAS positive, 7 negative) and not tested in 11 cases (52.4%). However, there has been progressive improvement in following guidelines for testing of KRAS from 2008-2012 from 45% (2008), 50% (2009), 75% (2010), 75% (2011) to 100% in 2012. 

Treatment was found to have 100% compliance with NCCN guidelines according to TNM classification.  Surveillance according to NCCN guidelines was in full compliance in 59 cases (77.7%), incomplete follow up in 17 cases (22.3%) with missing CT chest or CEA, and from which only 1 patient was missing follow up colonoscopy (1.3%).

 Conclusions: Complete compliance with 100% appropriate therapy was offered to veterans at one VA according to NCCN guidelines from 2008-2012. Aside from omitting CT chest when replaced by normal CXR, workup was complete in 90% of cases. Improvement in testing for KRAS/BRAF in stage IV colorectal carcinoma was done over the years with achievement of 100% in 2012. Surveillance was satisfactory as incomplete follow up was found in only 20%.  Given the future emphasis on cancer survivorship, a focus on adherence to surveillance should be a strong part of the VA’s future goals.

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2014 AVAHO meeting, cancer, Abstract 58, colorectal carcinoma, testing for KRAS/BRAF in stage IV colorectal carcinoma, adherence to surveillance
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Gavrancic T, Liu Q, Jain V, Park Y-HA.
Gavrancic T, Liu Q, Jain V, Park Y-HA.

Purpose: This study was performed in order to evaluate if patients were offered or received appropriate workup and treatment according to colon cancer stage. Rectal cancer was diagnosed in 3 and colon cancer in 81 patients over 5 years.  Patients were diagnosed with stage I in 26 cases (30%), stage II in 21 cases (25%), stage III in 15 cases (17.9 %), stage IV in 21 cases (25%), and 1 patient TIS (0.1%).

Methods: The study was designed as a retrospective single institution (JJP VAMC ) chart review of all patients who were diagnosed with colorectal cancer from 1/1/2008-12/31/2012 which included a total of 86 patients. NCCN guidelines 2014 were used as reference for workup, treatment and surveillance according to TNM classification. Data elements included the following: pre-operative CEA/ CT chest, abdomen, pelvis, colonoscopy; surgical resection and chemotherapy; follow up CEA, CT, colonoscopy. Excluded patients included those who eloped or were permanently lost follow up.

Results: Complete workup was done in 64% cases, incomplete in 36% cases without significant difference from 2008-2012. Incomplete workup defined as: missing CT chest (in 100% of those cases CXR was done and without mass suggestive for metastasis) 11 cases, CEA 3 cases, CT abdomen, pelvis and chest in 1 case, and both CT and CEA in 7 cases.  Stage IV colorectal carcinoma patients were tested for KRAS/BRAF in 10 cases  (47.6%; 3 KRAS positive, 7 negative) and not tested in 11 cases (52.4%). However, there has been progressive improvement in following guidelines for testing of KRAS from 2008-2012 from 45% (2008), 50% (2009), 75% (2010), 75% (2011) to 100% in 2012. 

Treatment was found to have 100% compliance with NCCN guidelines according to TNM classification.  Surveillance according to NCCN guidelines was in full compliance in 59 cases (77.7%), incomplete follow up in 17 cases (22.3%) with missing CT chest or CEA, and from which only 1 patient was missing follow up colonoscopy (1.3%).

 Conclusions: Complete compliance with 100% appropriate therapy was offered to veterans at one VA according to NCCN guidelines from 2008-2012. Aside from omitting CT chest when replaced by normal CXR, workup was complete in 90% of cases. Improvement in testing for KRAS/BRAF in stage IV colorectal carcinoma was done over the years with achievement of 100% in 2012. Surveillance was satisfactory as incomplete follow up was found in only 20%.  Given the future emphasis on cancer survivorship, a focus on adherence to surveillance should be a strong part of the VA’s future goals.

Purpose: This study was performed in order to evaluate if patients were offered or received appropriate workup and treatment according to colon cancer stage. Rectal cancer was diagnosed in 3 and colon cancer in 81 patients over 5 years.  Patients were diagnosed with stage I in 26 cases (30%), stage II in 21 cases (25%), stage III in 15 cases (17.9 %), stage IV in 21 cases (25%), and 1 patient TIS (0.1%).

Methods: The study was designed as a retrospective single institution (JJP VAMC ) chart review of all patients who were diagnosed with colorectal cancer from 1/1/2008-12/31/2012 which included a total of 86 patients. NCCN guidelines 2014 were used as reference for workup, treatment and surveillance according to TNM classification. Data elements included the following: pre-operative CEA/ CT chest, abdomen, pelvis, colonoscopy; surgical resection and chemotherapy; follow up CEA, CT, colonoscopy. Excluded patients included those who eloped or were permanently lost follow up.

Results: Complete workup was done in 64% cases, incomplete in 36% cases without significant difference from 2008-2012. Incomplete workup defined as: missing CT chest (in 100% of those cases CXR was done and without mass suggestive for metastasis) 11 cases, CEA 3 cases, CT abdomen, pelvis and chest in 1 case, and both CT and CEA in 7 cases.  Stage IV colorectal carcinoma patients were tested for KRAS/BRAF in 10 cases  (47.6%; 3 KRAS positive, 7 negative) and not tested in 11 cases (52.4%). However, there has been progressive improvement in following guidelines for testing of KRAS from 2008-2012 from 45% (2008), 50% (2009), 75% (2010), 75% (2011) to 100% in 2012. 

Treatment was found to have 100% compliance with NCCN guidelines according to TNM classification.  Surveillance according to NCCN guidelines was in full compliance in 59 cases (77.7%), incomplete follow up in 17 cases (22.3%) with missing CT chest or CEA, and from which only 1 patient was missing follow up colonoscopy (1.3%).

 Conclusions: Complete compliance with 100% appropriate therapy was offered to veterans at one VA according to NCCN guidelines from 2008-2012. Aside from omitting CT chest when replaced by normal CXR, workup was complete in 90% of cases. Improvement in testing for KRAS/BRAF in stage IV colorectal carcinoma was done over the years with achievement of 100% in 2012. Surveillance was satisfactory as incomplete follow up was found in only 20%.  Given the future emphasis on cancer survivorship, a focus on adherence to surveillance should be a strong part of the VA’s future goals.

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One Veterans Affairs Medical Center’s Experience with Colorectal Carcinoma
Display Headline
One Veterans Affairs Medical Center’s Experience with Colorectal Carcinoma
Legacy Keywords
2014 AVAHO meeting, cancer, Abstract 58, colorectal carcinoma, testing for KRAS/BRAF in stage IV colorectal carcinoma, adherence to surveillance
Legacy Keywords
2014 AVAHO meeting, cancer, Abstract 58, colorectal carcinoma, testing for KRAS/BRAF in stage IV colorectal carcinoma, adherence to surveillance
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