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Key clinical point: Nomograms for both recurrence-free survival and overall survival based on tumor clinical features, operative factors, liver function, and systemic inflammatory or immune status were effective predictors for stratifying SLH-HCC patients in low-, medium-, and high-risk groups.
Major finding: Nomograms for post-surgical recurrence-free survival and overall survival in patients with SLH-HCC achieved C-indexes of 0.85 and 0.86, respectively. The nomograms were based on diameter, differentiation, microvascular invasion, α-fetoprotein, preoperative transcatheter arterial chemoembolisation therapy, scope of liver resection and intraoperative blood transfusion, albumin-bilirubin grade, and neutrophil-to-lymphocyte ratio.
Study details: The data come from a retrospective study of 2,469 adult patients with single large and huge hepatocellular carcinoma (SLH-HCC) defined as greater than 5.0 cm in diameter who underwent curative resection between January 2005 and December 2015.
Disclosures: The study was supported by the National Science and Technology Major Project of China, the National Natural Science Foundation of China, and the Sun-Yat Sen University Clinical Research 5010 Program. The researchers had no financial conflicts to disclose.
Source: Wang J-C et al. Eur J Cancer. 2021 Aug 6. doi: 10.1016/j.ejca.2021.07.009.
Key clinical point: Nomograms for both recurrence-free survival and overall survival based on tumor clinical features, operative factors, liver function, and systemic inflammatory or immune status were effective predictors for stratifying SLH-HCC patients in low-, medium-, and high-risk groups.
Major finding: Nomograms for post-surgical recurrence-free survival and overall survival in patients with SLH-HCC achieved C-indexes of 0.85 and 0.86, respectively. The nomograms were based on diameter, differentiation, microvascular invasion, α-fetoprotein, preoperative transcatheter arterial chemoembolisation therapy, scope of liver resection and intraoperative blood transfusion, albumin-bilirubin grade, and neutrophil-to-lymphocyte ratio.
Study details: The data come from a retrospective study of 2,469 adult patients with single large and huge hepatocellular carcinoma (SLH-HCC) defined as greater than 5.0 cm in diameter who underwent curative resection between January 2005 and December 2015.
Disclosures: The study was supported by the National Science and Technology Major Project of China, the National Natural Science Foundation of China, and the Sun-Yat Sen University Clinical Research 5010 Program. The researchers had no financial conflicts to disclose.
Source: Wang J-C et al. Eur J Cancer. 2021 Aug 6. doi: 10.1016/j.ejca.2021.07.009.
Key clinical point: Nomograms for both recurrence-free survival and overall survival based on tumor clinical features, operative factors, liver function, and systemic inflammatory or immune status were effective predictors for stratifying SLH-HCC patients in low-, medium-, and high-risk groups.
Major finding: Nomograms for post-surgical recurrence-free survival and overall survival in patients with SLH-HCC achieved C-indexes of 0.85 and 0.86, respectively. The nomograms were based on diameter, differentiation, microvascular invasion, α-fetoprotein, preoperative transcatheter arterial chemoembolisation therapy, scope of liver resection and intraoperative blood transfusion, albumin-bilirubin grade, and neutrophil-to-lymphocyte ratio.
Study details: The data come from a retrospective study of 2,469 adult patients with single large and huge hepatocellular carcinoma (SLH-HCC) defined as greater than 5.0 cm in diameter who underwent curative resection between January 2005 and December 2015.
Disclosures: The study was supported by the National Science and Technology Major Project of China, the National Natural Science Foundation of China, and the Sun-Yat Sen University Clinical Research 5010 Program. The researchers had no financial conflicts to disclose.
Source: Wang J-C et al. Eur J Cancer. 2021 Aug 6. doi: 10.1016/j.ejca.2021.07.009.