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Key clinical point: Meta-analysis indicated a relatively higher but nonsignificantly increased risk for Helicobacter pylori infection (HPI) in patients with irritable bowel syndrome (IBS) vs non-IBS participants; however, the association between IBS and HPI could be an underestimation, with a positive association persisting between HPI and diarrhea-type IBS (IBS-D).
Major finding: A nonsignificant positive association was observed between HPI and IBS (odds ratio [OR], 1.03 ;lt; P = .84); however, the association was significant after excluding studies with defined confounding factors (adjusted OR, 1.29; P = .03), indicating an underestimation. The positive association of HPI persisted with IBS-D (OR, 1.54; P = .0003) but not with IBS-C (P = .17) or IBS-M (P = .33).
Study details: Findings are from a systematic review and meta-analysis of 13 studies including 1,403 patients with IBS and 11,770 non-IBS participants.
Disclosures: This research was funded by the National Natural Science Foundation of China and the Natural Science Foundation of Guangdong Province. The authors declared no conflicts of interest.
Source: Wang Z et al. Helicobacterpylori infection-A risk factor for irritable bowel syndrome? An updated systematic review and meta-analysis. Medicina (Kaunas). 2022;58(8):1035 (Aug 2). Doi: 10.3390/medicina58081035.
Key clinical point: Meta-analysis indicated a relatively higher but nonsignificantly increased risk for Helicobacter pylori infection (HPI) in patients with irritable bowel syndrome (IBS) vs non-IBS participants; however, the association between IBS and HPI could be an underestimation, with a positive association persisting between HPI and diarrhea-type IBS (IBS-D).
Major finding: A nonsignificant positive association was observed between HPI and IBS (odds ratio [OR], 1.03 ;lt; P = .84); however, the association was significant after excluding studies with defined confounding factors (adjusted OR, 1.29; P = .03), indicating an underestimation. The positive association of HPI persisted with IBS-D (OR, 1.54; P = .0003) but not with IBS-C (P = .17) or IBS-M (P = .33).
Study details: Findings are from a systematic review and meta-analysis of 13 studies including 1,403 patients with IBS and 11,770 non-IBS participants.
Disclosures: This research was funded by the National Natural Science Foundation of China and the Natural Science Foundation of Guangdong Province. The authors declared no conflicts of interest.
Source: Wang Z et al. Helicobacterpylori infection-A risk factor for irritable bowel syndrome? An updated systematic review and meta-analysis. Medicina (Kaunas). 2022;58(8):1035 (Aug 2). Doi: 10.3390/medicina58081035.
Key clinical point: Meta-analysis indicated a relatively higher but nonsignificantly increased risk for Helicobacter pylori infection (HPI) in patients with irritable bowel syndrome (IBS) vs non-IBS participants; however, the association between IBS and HPI could be an underestimation, with a positive association persisting between HPI and diarrhea-type IBS (IBS-D).
Major finding: A nonsignificant positive association was observed between HPI and IBS (odds ratio [OR], 1.03 ;lt; P = .84); however, the association was significant after excluding studies with defined confounding factors (adjusted OR, 1.29; P = .03), indicating an underestimation. The positive association of HPI persisted with IBS-D (OR, 1.54; P = .0003) but not with IBS-C (P = .17) or IBS-M (P = .33).
Study details: Findings are from a systematic review and meta-analysis of 13 studies including 1,403 patients with IBS and 11,770 non-IBS participants.
Disclosures: This research was funded by the National Natural Science Foundation of China and the Natural Science Foundation of Guangdong Province. The authors declared no conflicts of interest.
Source: Wang Z et al. Helicobacterpylori infection-A risk factor for irritable bowel syndrome? An updated systematic review and meta-analysis. Medicina (Kaunas). 2022;58(8):1035 (Aug 2). Doi: 10.3390/medicina58081035.