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Hypothermia Therapy in Traumatic Brain Injury
Assessing its efficacy

In patients with an intracranial pressure of more than 20 mm Hg after traumatic brain injury (TBI), therapeutic hypothermia plus standard care to reduce intracranial pressure did not result in outcomes better than those with standard care alone, according to a study of 387 patients with TBI. Researchers found:

• Stage 3 treatments were needed to control intracranial pressure in 54% of controls and 44% of the hypothermia group.

• Adjusted common odds ratio for the Extended Glasgow Outcome Scale (GOS-E) was 1.53, indicating a worse outcome in the hypothermia group vs controls.

• A favorable outcome occurred in 26% of the hypothermia group vs 37% in controls. 

Citation: Andrews PJ, Sinclair HL, Rodriguez A, et al. Hypothermia for intracranial hypertension after traumatic brain injury. [Published online ahead of print October 7, 2015]. N Engl J Med. doi: 10.1056/NEJMoa1507581.

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Assessing its efficacy
Assessing its efficacy

In patients with an intracranial pressure of more than 20 mm Hg after traumatic brain injury (TBI), therapeutic hypothermia plus standard care to reduce intracranial pressure did not result in outcomes better than those with standard care alone, according to a study of 387 patients with TBI. Researchers found:

• Stage 3 treatments were needed to control intracranial pressure in 54% of controls and 44% of the hypothermia group.

• Adjusted common odds ratio for the Extended Glasgow Outcome Scale (GOS-E) was 1.53, indicating a worse outcome in the hypothermia group vs controls.

• A favorable outcome occurred in 26% of the hypothermia group vs 37% in controls. 

Citation: Andrews PJ, Sinclair HL, Rodriguez A, et al. Hypothermia for intracranial hypertension after traumatic brain injury. [Published online ahead of print October 7, 2015]. N Engl J Med. doi: 10.1056/NEJMoa1507581.

In patients with an intracranial pressure of more than 20 mm Hg after traumatic brain injury (TBI), therapeutic hypothermia plus standard care to reduce intracranial pressure did not result in outcomes better than those with standard care alone, according to a study of 387 patients with TBI. Researchers found:

• Stage 3 treatments were needed to control intracranial pressure in 54% of controls and 44% of the hypothermia group.

• Adjusted common odds ratio for the Extended Glasgow Outcome Scale (GOS-E) was 1.53, indicating a worse outcome in the hypothermia group vs controls.

• A favorable outcome occurred in 26% of the hypothermia group vs 37% in controls. 

Citation: Andrews PJ, Sinclair HL, Rodriguez A, et al. Hypothermia for intracranial hypertension after traumatic brain injury. [Published online ahead of print October 7, 2015]. N Engl J Med. doi: 10.1056/NEJMoa1507581.

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Hypothermia Therapy in Traumatic Brain Injury
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Hypothermia Therapy in Traumatic Brain Injury
Legacy Keywords
traumatic brain injury, TBI, hypothermia
Legacy Keywords
traumatic brain injury, TBI, hypothermia
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