User login
in the renal glomeruli,
the network responsible
for filtering the blood
Credit: Human Protein Atlas
Scientists say they’ve completed the first major analysis based on the Human Protein Atlas, providing a detailed picture of proteins linked to cancer, the number of proteins present in the bloodstream, and all proteins targeted by drugs.
The group described their work in Science.
The Human Protein Atlas, a multinational research project, recently launched an open-source, tissue-based, interactive map of the human proteome.
In the Science article, researchers described how they studied the human proteome. The group analyzed samples representing the 44 major tissues and organs in the human body.
They used 24,028 antibodies, corresponding to 16,975 protein-encoding genes, to produce more than 13 million tissue-based immunohistochemistry images. They complemented this analysis with RNA-sequencing data for 32 of the 44 tissue types.
In this way, the scientists mapped the distribution of proteins in all major tissues and organs in the human body. They identified proteins restricted to certain tissues—such as the brain, heart, or liver—and those present throughout the body.
Almost half of the nearly 17,000 protein-encoding genes are expressed in all the tissues the researchers analyzed. The group also found that 3171 proteins are secreted from cells, and 5570 are located in the membrane systems of cells.
“This is important information for the pharmaceutical industry,” said study author Mathias Uhlén, PhD, a professor at the KTH Royal Institute of Technology in Stockholm, Sweden, and the director of the Human Protein Atlas program.
“We show that 70% of the current targets for approved pharmaceutical drugs are either secreted or membrane-bound proteins. Interestingly, 30% of these protein targets are found in all analyzed tissues and organs. This could help explain some side effects of drugs and, thus, might have consequences for future drug development.” 
in the renal glomeruli,
the network responsible
for filtering the blood
Credit: Human Protein Atlas
Scientists say they’ve completed the first major analysis based on the Human Protein Atlas, providing a detailed picture of proteins linked to cancer, the number of proteins present in the bloodstream, and all proteins targeted by drugs.
The group described their work in Science.
The Human Protein Atlas, a multinational research project, recently launched an open-source, tissue-based, interactive map of the human proteome.
In the Science article, researchers described how they studied the human proteome. The group analyzed samples representing the 44 major tissues and organs in the human body.
They used 24,028 antibodies, corresponding to 16,975 protein-encoding genes, to produce more than 13 million tissue-based immunohistochemistry images. They complemented this analysis with RNA-sequencing data for 32 of the 44 tissue types.
In this way, the scientists mapped the distribution of proteins in all major tissues and organs in the human body. They identified proteins restricted to certain tissues—such as the brain, heart, or liver—and those present throughout the body.
Almost half of the nearly 17,000 protein-encoding genes are expressed in all the tissues the researchers analyzed. The group also found that 3171 proteins are secreted from cells, and 5570 are located in the membrane systems of cells.
“This is important information for the pharmaceutical industry,” said study author Mathias Uhlén, PhD, a professor at the KTH Royal Institute of Technology in Stockholm, Sweden, and the director of the Human Protein Atlas program.
“We show that 70% of the current targets for approved pharmaceutical drugs are either secreted or membrane-bound proteins. Interestingly, 30% of these protein targets are found in all analyzed tissues and organs. This could help explain some side effects of drugs and, thus, might have consequences for future drug development.”
in the renal glomeruli,
the network responsible
for filtering the blood
Credit: Human Protein Atlas
Scientists say they’ve completed the first major analysis based on the Human Protein Atlas, providing a detailed picture of proteins linked to cancer, the number of proteins present in the bloodstream, and all proteins targeted by drugs.
The group described their work in Science.
The Human Protein Atlas, a multinational research project, recently launched an open-source, tissue-based, interactive map of the human proteome.
In the Science article, researchers described how they studied the human proteome. The group analyzed samples representing the 44 major tissues and organs in the human body.
They used 24,028 antibodies, corresponding to 16,975 protein-encoding genes, to produce more than 13 million tissue-based immunohistochemistry images. They complemented this analysis with RNA-sequencing data for 32 of the 44 tissue types.
In this way, the scientists mapped the distribution of proteins in all major tissues and organs in the human body. They identified proteins restricted to certain tissues—such as the brain, heart, or liver—and those present throughout the body.
Almost half of the nearly 17,000 protein-encoding genes are expressed in all the tissues the researchers analyzed. The group also found that 3171 proteins are secreted from cells, and 5570 are located in the membrane systems of cells.
“This is important information for the pharmaceutical industry,” said study author Mathias Uhlén, PhD, a professor at the KTH Royal Institute of Technology in Stockholm, Sweden, and the director of the Human Protein Atlas program.
“We show that 70% of the current targets for approved pharmaceutical drugs are either secreted or membrane-bound proteins. Interestingly, 30% of these protein targets are found in all analyzed tissues and organs. This could help explain some side effects of drugs and, thus, might have consequences for future drug development.”