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Purpose
Biorepositories are critical to scientific research within the VA. They offer high-quality, well-characterized biospecimens linked to clinical, demographic, and molecular data. Biorepositories support studies on disease mechanisms, personalized therapies, and emerging infectious diseases by systematically collecting, processing, storing, and distributing biological materials, including tissue, blood, and DNA samples. Within the Department of Veterans Affairs (VA), biorepositories provide essential support to clinical and translational research on service- related conditions such as PTSD, traumatic brain injury, cancers, and toxic exposures. While the need for harmonized quality processes and resource allocation has long been acknowledged within the biorepository community (Siwek, 2015), each biorepository operates independently, limiting scalability and standardization. This quality improvement project describes a collaboration between two VA biorepository sites supporting a national genomic study investigating disease risk and treatment outcomes. The project aimed to expand capacity, improve processing times, and enhance quality control. Each site mirrors the other’s functions, including receiving, accessioning, processing, storing, and shipping biospecimens, and serves as a contingency site to strengthen operational resilience.
Methods
To address space limitations and improve processing efficiency, one site implemented a custom rack design, expanding storage capacity per freezer. Robotic workflows were optimized, reducing biospecimen processing time. An in-process quality control step was introduced to identify data discrepancies earlier in the workflow, reducing investigation time and supporting overall data integrity. Efficiency was measured by the increase in storage capacity and decreased processing time. Descriptive statistics were used to evaluate changes in performance. Metrics were monitored over twelve months and compared against baseline data.
Results
Following implementation, storage capacity per freezer increased by 20%, and specimen processing time decreased by 30%. The new quality control checkpoint reduced investigation times by 98%, resulting in a more streamlined workflow. These improvements enhanced coordination between sites and improved support for ongoing studies.
Conclusions
This effort demonstrates that collaboration between biorepositories can significantly enhance efficiency, reduce turnaround times, and support high-quality research. Strengthening infrastructure through joint initiatives enables more effective support of large-scale clinical studies and contributes to improved outcomes for Veterans. These findings may also inform process improvements at other VA research facilities.
Purpose
Biorepositories are critical to scientific research within the VA. They offer high-quality, well-characterized biospecimens linked to clinical, demographic, and molecular data. Biorepositories support studies on disease mechanisms, personalized therapies, and emerging infectious diseases by systematically collecting, processing, storing, and distributing biological materials, including tissue, blood, and DNA samples. Within the Department of Veterans Affairs (VA), biorepositories provide essential support to clinical and translational research on service- related conditions such as PTSD, traumatic brain injury, cancers, and toxic exposures. While the need for harmonized quality processes and resource allocation has long been acknowledged within the biorepository community (Siwek, 2015), each biorepository operates independently, limiting scalability and standardization. This quality improvement project describes a collaboration between two VA biorepository sites supporting a national genomic study investigating disease risk and treatment outcomes. The project aimed to expand capacity, improve processing times, and enhance quality control. Each site mirrors the other’s functions, including receiving, accessioning, processing, storing, and shipping biospecimens, and serves as a contingency site to strengthen operational resilience.
Methods
To address space limitations and improve processing efficiency, one site implemented a custom rack design, expanding storage capacity per freezer. Robotic workflows were optimized, reducing biospecimen processing time. An in-process quality control step was introduced to identify data discrepancies earlier in the workflow, reducing investigation time and supporting overall data integrity. Efficiency was measured by the increase in storage capacity and decreased processing time. Descriptive statistics were used to evaluate changes in performance. Metrics were monitored over twelve months and compared against baseline data.
Results
Following implementation, storage capacity per freezer increased by 20%, and specimen processing time decreased by 30%. The new quality control checkpoint reduced investigation times by 98%, resulting in a more streamlined workflow. These improvements enhanced coordination between sites and improved support for ongoing studies.
Conclusions
This effort demonstrates that collaboration between biorepositories can significantly enhance efficiency, reduce turnaround times, and support high-quality research. Strengthening infrastructure through joint initiatives enables more effective support of large-scale clinical studies and contributes to improved outcomes for Veterans. These findings may also inform process improvements at other VA research facilities.
Purpose
Biorepositories are critical to scientific research within the VA. They offer high-quality, well-characterized biospecimens linked to clinical, demographic, and molecular data. Biorepositories support studies on disease mechanisms, personalized therapies, and emerging infectious diseases by systematically collecting, processing, storing, and distributing biological materials, including tissue, blood, and DNA samples. Within the Department of Veterans Affairs (VA), biorepositories provide essential support to clinical and translational research on service- related conditions such as PTSD, traumatic brain injury, cancers, and toxic exposures. While the need for harmonized quality processes and resource allocation has long been acknowledged within the biorepository community (Siwek, 2015), each biorepository operates independently, limiting scalability and standardization. This quality improvement project describes a collaboration between two VA biorepository sites supporting a national genomic study investigating disease risk and treatment outcomes. The project aimed to expand capacity, improve processing times, and enhance quality control. Each site mirrors the other’s functions, including receiving, accessioning, processing, storing, and shipping biospecimens, and serves as a contingency site to strengthen operational resilience.
Methods
To address space limitations and improve processing efficiency, one site implemented a custom rack design, expanding storage capacity per freezer. Robotic workflows were optimized, reducing biospecimen processing time. An in-process quality control step was introduced to identify data discrepancies earlier in the workflow, reducing investigation time and supporting overall data integrity. Efficiency was measured by the increase in storage capacity and decreased processing time. Descriptive statistics were used to evaluate changes in performance. Metrics were monitored over twelve months and compared against baseline data.
Results
Following implementation, storage capacity per freezer increased by 20%, and specimen processing time decreased by 30%. The new quality control checkpoint reduced investigation times by 98%, resulting in a more streamlined workflow. These improvements enhanced coordination between sites and improved support for ongoing studies.
Conclusions
This effort demonstrates that collaboration between biorepositories can significantly enhance efficiency, reduce turnaround times, and support high-quality research. Strengthening infrastructure through joint initiatives enables more effective support of large-scale clinical studies and contributes to improved outcomes for Veterans. These findings may also inform process improvements at other VA research facilities.