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Key clinical point: A combination of atezolizumab plus bevacizumab showed therapeutic potential for adults with unresectable HCC, as patients showed a strong initial therapeutic response; the most common adverse events were appetite loss, fatigue, and urine protein.
Major finding: After 6 weeks, the overall objective response rate for early tumor shrinkage was 10.6% and the disease control rate was 79.6%; results were similar for the subset of patients with no prior history of systemic treatment (9.7% and 12.2%).
Study details: The data come from a retrospective study of 171 adults with unresectable hepatocellular carcinoma who were treated with a combination of atezolizumab plus bevacizumab; 75 of these had no prior history of systemic treatment.
Disclosures: The study was supported by the Institutional Ethics Committee of Ehime Prefectural Central Hospital. The researchers had no financial conflicts to disclose.
Source: Hiraoka A et al. Cancer Rep. 2021 Jun 11. doi: 10.1002/cnr2.1464.
Key clinical point: A combination of atezolizumab plus bevacizumab showed therapeutic potential for adults with unresectable HCC, as patients showed a strong initial therapeutic response; the most common adverse events were appetite loss, fatigue, and urine protein.
Major finding: After 6 weeks, the overall objective response rate for early tumor shrinkage was 10.6% and the disease control rate was 79.6%; results were similar for the subset of patients with no prior history of systemic treatment (9.7% and 12.2%).
Study details: The data come from a retrospective study of 171 adults with unresectable hepatocellular carcinoma who were treated with a combination of atezolizumab plus bevacizumab; 75 of these had no prior history of systemic treatment.
Disclosures: The study was supported by the Institutional Ethics Committee of Ehime Prefectural Central Hospital. The researchers had no financial conflicts to disclose.
Source: Hiraoka A et al. Cancer Rep. 2021 Jun 11. doi: 10.1002/cnr2.1464.
Key clinical point: A combination of atezolizumab plus bevacizumab showed therapeutic potential for adults with unresectable HCC, as patients showed a strong initial therapeutic response; the most common adverse events were appetite loss, fatigue, and urine protein.
Major finding: After 6 weeks, the overall objective response rate for early tumor shrinkage was 10.6% and the disease control rate was 79.6%; results were similar for the subset of patients with no prior history of systemic treatment (9.7% and 12.2%).
Study details: The data come from a retrospective study of 171 adults with unresectable hepatocellular carcinoma who were treated with a combination of atezolizumab plus bevacizumab; 75 of these had no prior history of systemic treatment.
Disclosures: The study was supported by the Institutional Ethics Committee of Ehime Prefectural Central Hospital. The researchers had no financial conflicts to disclose.
Source: Hiraoka A et al. Cancer Rep. 2021 Jun 11. doi: 10.1002/cnr2.1464.